CLUSTAL W (1.83) multiple sequence alignment PIM3_Hsap M----------------------------------------------------------- PIM2_Hsap MAPIGCGTAGAA-SGLIKARWAGLSPRVT--LPGGACPGSVALGLARAANLNAAPSAGAS PIM1_Hsap MPHEPHEPLTPPFSALPDP-AGAPSRRQSRQRPQLSSDSPSAFRASRSHSRNATRSHSHS PIM3_Mmus M----------------------------------------------------------- PIM2_Mmus MARIGWGTAGAA-SGLIKARWAGLSRRAT--LPGGACPGSVALGLARATNLNAAPSAGAS PIM1_Mmus MGP--AAPLALPPPALPDP-AGEPARGQPRQRPQSSSDSPSALRASRSQSRNATRSLS-- prk-2_Cele MK---------------------------------------------------------- prk-1_Cele MI---------------------------------------------------------- Pim_Spur MNLP-------------------------------------------------------- * PIM3_Hsap --------------------------------------LLSKFG-SL-A-HLCGPGGVDH PIM2_Hsap GPPV-SLLSTLAPPSPGSPA-ALPRASTPCGLSGFSGLNLRSAT-SMLTKPLQGPP-APP PIM1_Hsap HSPRHSLRH-----SPGSGSCGSSSGHRPCADILEVGMLLSKIN-SL-A-HLRAAP-CND PIM3_Mmus --------------------------------------LLSKFG-SL-A-HLCGPGGVDH PIM2_Mmus GPPD-SLPSTLAPPSPGSPA-ALPRASTPCGLSGFSGLNIRSTS-SMLTKPLQGHP-SPP PIM1_Mmus --PGRRLSP-----SSLRRRCC-SSRHRRRTDTLEVGMLLSKIN-SL-A-HLRAAP-CND prk-2_Cele -----------------------------------------KLA-SL-Q----FF-NL-- prk-1_Cele ---------------------------------------KRKLQ-DL-A-VCCSY-QV-- Pim_Spur ----------------------------------------RKLTSQF-A-EICSMN-VKN . .: PIM3_Hsap LPVKILQPAK--ADKESFEKAYQVGAVLGSGGFGTVYAGSRIAD-GLPVAVKHVVKERVT PIM2_Hsap GTPTP-PPGG--KDREAFEAEYRLGPLLGKGGFGTVFAGHRLTD-RLQVAIKVIPRNRVL PIM1_Hsap LHATKLAPG---KEKEPLESQYQVGPLLGSGGFGSVYSGIRVSD-NLPVAIKHVEKDRIS PIM3_Mmus LPVKILQPAK--ADKESFEKVYQVGAVLGSGGFGTVYAGSRIAD-GLPVAVKHVVKERVT PIM2_Mmus VTPTQ-PPGG--KDRAAFEAEYRLGPLLGKGGFGTVFAGHRVTD-RRQVAIKVISRNRVL PIM1_Mmus LHATKLAPG---KEKEPLESQYQVGPLLGSGGFGSVYSGIRVAD-NLPVAIKHVEKDRIS prk-2_Cele ---KLLLNGESSRGFSKFKKNYKLKAELGRGGFGVVYRAVRTCD-NALVAVKFIERSNVK prk-1_Cele ---DFLHEKK--HSVKEFKRKYEVLDEIGRGGFGIVYEATTRQDGQQPVAVKFVQHKHVR Pim_Spur MGRTTADRNG--KQRESFEKTYSIGSLIGSGGFGTVYAGSRISD-NLPVAIKLVNKEKVN :: * : :* **** *: . * **:* : :..: PIM3_Hsap EWGSL-GGATVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFI PIM2_Hsap GWSPLSDSVTCPLEVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYI PIM1_Hsap DWGELPNGTRVPMEVVLLKKVSS--GFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFI PIM3_Mmus EWGSL-GGVAVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFI PIM2_Mmus GWSTVSDSVTCPLEVALLWKVGEGNGHPGVIRLLDWFETPEGFMLVLERPMPAQDLFDYI PIM1_Mmus DWGELPNGTRVPMEVVLLKKVSS--DFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFI prk-2_Cele EWARI-NGEQVPMEICMLAKCS---KVRGVIRLLDWYSIPEGFLIVMERPYPCIDMFDFI prk-1_Cele SWTMT-CRQLIPSEVCHLETCE---DIPGVIKILDWFANSKGFLIVMERPANCMDLFDMV Pim_Spur DWVQL-NGREVPLEVSLLKRVSS---IHGCISMLDYFEQPDSFVIVMERPDPAKDLFDFI * * *: * * * :**:: ..*::::*** *:** : PIM3_Hsap TERGALDEPLARRFFAQVLAAVRHCHS-CGVVHRDIKDENLLVDLRSGELKLIDFGSGAL PIM2_Hsap TEKGPLGEGPSRCFFGQVVAAIQHCHS-RGVVHRDIKDENILIDLRRGCAKLIDFGSGAL PIM1_Hsap TERGALQEELARSFFWQVLEAVRHCHN-CGVLHRDIKDENILIDLNRGELKLIDFGSGAL PIM3_Mmus TERGALDEPLARRFFAQVLAAVRHCHN-CGVVHRDIKDENLLVDLRSGELKLIDFGSGAV PIM2_Mmus TEKGPLGESCSRSFFTQVVAAVQHCHA-RGVVHRDIKDENILIDLCRGSIKLIDFGSGAL PIM1_Mmus TERGALQEDLARGFFWQVLEAVRHCHN-CGVLHRDIKDENILIDLSRGEIKLIDFGSGAL prk-2_Cele KGQGKISEDMARFLFRQIAVTVHECVQ-NRVLHRDLKDENIVIDLVTGSTKLIDFGAATV prk-1_Cele SVHGPLNEDMGKFIFKQVITTVFNMYSKHGLLHRDIKDENLIVNMNTGEVKLVDFGATAY Pim_Spur TEQGPLPEELCRRFFKQMW----------------------------------KLQAAAM . :* : * : :* *: .: : : PIM3_Hsap LKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVCGDIPFEQDEEILRGR PIM2_Hsap LHDEPYTDFDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFERDQEILEAE PIM1_Hsap LKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQ PIM3_Mmus LKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVCGDIPFEQDEEILRGR PIM2_Mmus LHDEPYTDFDGTRVYSPPEWISRHQYHALPATVWSLGVLLYDMVCGDIPFERDQEILEAE PIM1_Mmus LKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIKGQ prk-2_Cele LRRSQYSDFQGTRLYCPPEWFLHSLYLGREAAVWSLGVLLYNSLNGRLPFRNEKDICTAH prk-1_Cele AEKATKKEFQGTRSYCPPEWFRDQLYLPLEATSWSLGVLLFILLTGKLPFRNEIQICLGN Pim_Spur RLDTVYKDFDGTRVYSPPEWITSHRYHGRSATIWSLGILLFDMACGDIPFEKDDEICRAE .:*:*** *.****: * *: ****:**: * :**..: :* .. PIM3_Hsap ----LLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWMLGADGGV-----PE-S-- PIM2_Hsap ----LHFPAHVSPDCCALIRRCLAPKPSSRPSLEEILLDPWMQTPAEDV-----PLNP-- PIM1_Hsap ----VFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVL--L-----PQET-- PIM3_Mmus ----LFFRRRVSPECQQLIEWCLSLRPSERPSLDQIAAHPWMLGTEGSV-----PE-N-- PIM2_Mmus ----LHFPAHVSPDCCALIRRCLAPKPCSRPSLEEILLDPWMQSPAEEK-----PINS-- PIM1_Mmus ----VFFRQTVSSECQHLIKWCLSLRPSDRPSFEEIRNHPWMQGDL--L-----PQAA-- prk-2_Cele LLGPLPFFVPVSAEVKDLISKCLTFDPFQRCSLEAILNHPWVKQQTLSW--DALTKNK-- prk-1_Cele ----VKFPPDLSKEVCQLVKSCLTTSTSARASLAQIAAHPWMETDKPFFGGDLTFEEALM Pim_Spur ----LYFRDGLSHSLKNLIQSMLQVKPQHRLKIEDILDHPWMREGQTDNGGQ--KIIC-- : * :* . *: * . * .: * .**: PIM3_Hsap ------------------------------------------------------------ PIM2_Hsap ------------------------------------------------------------ PIM1_Hsap ------------------------------------------------------------ PIM3_Mmus ------------------------------------------------------------ PIM2_Mmus ------------------------------------------------------------ PIM1_Mmus ------------------------------------------------------------ prk-2_Cele -------------------------VQ--------------------------------- prk-1_Cele EIKNPPVVIEDKEAEEEDNDLNDVVILTRSRESRTDLDAESICTMVTAVEDRYEPSIAVK Pim_Spur ------------------------------------------------------------ PIM3_Hsap -------------------------------CD-LRLCTLDPDDVAST------------ PIM2_Hsap -------------------------------SK----------GGPAP------------ PIM1_Hsap -------------------------------AE-IHL---------HS------------ PIM3_Mmus -------------------------------CD-LRLCALDTDDGAST------------ PIM2_Mmus -------------------------------SK----------GSPTP------------ PIM1_Mmus -------------------------------SE-IHL---------HS------------ prk-2_Cele -----------------------------------KKTSESSDDHHSE---TLG------ prk-1_Cele ELEQEEIVETGETTNLMRSESRYDNISSSSFCDYVSLVSSSYDDQFTS---TSDIYQS-- Pim_Spur -------------------------------TG-HSMNSLDNSPYSSTNSSHEDIHKAQT PIM3_Hsap ------------------------------------------------------------ PIM2_Hsap ------------------------------------------------------------ PIM1_Hsap ------------------------------------------------------------ PIM3_Mmus ------------------------------------------------------------ PIM2_Mmus ------------------------------------------------------------ PIM1_Mmus ------------------------------------------------------------ prk-2_Cele --------------DHSETEED-------------------------------------- prk-1_Cele ---------ACEVFPHTGSSSSLSRSMGAVKSASAYNLVRMRKKSSIFKSFDTELDPVSE Pim_Spur CQCTVSHPSNC--FIHN--------------------------------------R--AS PIM3_Hsap ------------------------------------------------------------ PIM2_Hsap ------------------------------------------------------------ PIM1_Hsap ------------------------------------------------------------ PIM3_Mmus ------------------------------------------------------------ PIM2_Mmus ------------------------------------------------------------ PIM1_Mmus ------------------------------------------------------------ prk-2_Cele -----RSPPT-SSV-SQQPGSADEGVGLS------------------------------- prk-1_Cele NDHQPLIPET-SSATCQSTYSNDEDVTISEKVVSPAQPLPPPLSPRKGSLQCFESVPRSR Pim_Spur DVVS----QTLSSV-KLLSNSQDSDSSDSGIED------------GE------------- PIM3_Hsap ------------------------------TSSSESL PIM2_Hsap ------------------------------LAWSLLP PIM1_Hsap ------------------------------LSPGPSK PIM3_Mmus ------------------------------TSSSESL PIM2_Mmus ------------------------------LPWSLLP PIM1_Mmus ------------------------------LSPGSSK prk-2_Cele -----------------ASSSNT---VRIFIP-VVNM prk-1_Cele DSVIRMSRHRPLQFAIDSSSPPPALAIFQVSPTASVG Pim_Spur ------------------------VRDCLFVPIAQHS .