CLUSTAL W (1.83) multiple sequence alignment PKN3_Hsap MEE-GAPR---------------------------------------------------- PKN2_Hsap MASN-PERG--------------------------EILL--------------------- PKN1_Hsap MAEA-NNPS-----------------------------E--------------------- CG2049_Dmel MSKL-VKRI--------------------------RSMI--------------------- PKN3_Mmus MEPEGAVR---------------------------------------------------- PKN2_Mmus MASN-PDRG--------------------------EILL--------------------- PKN1_Mmus MAAD-P-PL-----------------------------D--------------------- F46F6.2_Cele MDYH-SNGNG--------------------------I----------------------- PKN_Spur MLQD-SKTK--------------------------------------------------- AqueK022_Aque MLIA-VTFSAFLKIEIVCIYGITAKKKRIEKRDRGEKLKSFACYLRPLLCLPLSSIKVNQ * PKN3_Hsap ------------------------------------------------------------ PKN2_Hsap ---TE------------------------------------------------------- PKN1_Hsap ---QE------------------------------------------------------- CG2049_Dmel ---NPSSQRDREDTTSVSASEGFIARRKCHS-----------------------LPRRSN PKN3_Mmus ------------------------------------------------------------ PKN2_Mmus ---TE------------------------------------------------------- PKN1_Mmus ---SE------------------------------------------------------- F46F6.2_Cele ---NGMNGSSR----------------------------------HSADGPST--PTHSG PKN_Spur ------------------------------------------------------------ AqueK022_Aque ALLYSMSSDLTSSLSSWRASV--------HLLLRHIWSLWYYKKAEEASEPSSCLPDSLF PKN3_Hsap ------------------------------------------------------------ PKN2_Hsap -------------------------------------------------------LQG-- PKN1_Hsap -------------------------------------------------------LES-- CG2049_Dmel RHSTARRSNSGLWNRLVTNVFGPEDSYDFDNEGDSGGAVFYTDSVNGSN--YEISAEGE- PKN3_Mmus ------------------------------------------------------------ PKN2_Mmus -------------------------------------------------------LQG-- PKN1_Mmus -------------------------------------------------------LES-- F46F6.2_Cele ---------------------------------------------NG-----HSNGEGNS PKN_Spur ------------------------------------------------------------ AqueK022_Aque ---------------------------------------------AGSTVCFLSGCHGE- PKN3_Hsap --------------------------Q-PGPSQWPPEDEKEVIRRAIQKELKIKEGVENL PKN2_Hsap -----DSRSLPFSENVSAVQKLDF---SDTMVQQKLDDIKDRIKREIRKELKIKEGAENL PKN1_Hsap -----EPRSWSLLEQLGL-AGADL---AAPGVQQQLELERERLRREIRKELKLKEGAENL CG2049_Dmel --YIKHPVLYELSHKYGF-T-ENL---PESCMSIRLEEIKEAIRREIRKELKIKEGAEKL PKN3_Mmus --------------------------Q-PGTGQRAPKDEKEMVRRAIQKELKIKEGMENM PKN2_Mmus -----DSRTLPFSENVSAVQKLDF---SDTMVQQKLDDIKDRIKREIRKELKIKEGAENL PKN1_Mmus -----EPRSWSLLEQLGL-AGADL---AAPGVQQQLELERERLKREIRKELKLKEGAENL F46F6.2_Cele TYWETAP--AEMVELAD---KYNFTINEGSSIQQEALELRSVIRKDLTKKLKIKSGYSRI PKN_Spur ---------------------------------------IEFIRMQI---LKT-QQAQQS AqueK022_Aque --KE-RP--AXLLKYSGF-NWKQI-LDMDGGNALDLDTLKESLRLEIRKEFKIKEGAENL . :: : :* . .. PKN3_Hsap RRVATDR-RHLGHVQQLLRSSNRRLEQLHGELRELHARILLPGPGPGP----AE------ PKN2_Hsap RKVTTDK-KSLAYVDNILKKSNKKLEELHHKLQELNAHIVVSDPEDITDCP-RT------ PKN1_Hsap RRATTDLGRSLGPVELLLRGSSRRLDLLHQQLQELHAHVVLPDPAATHDGP-QS------ CG2049_Dmel REVAKDR-RSLSDVAVLVKKSKSKLAELKSELQELESQILLTSANTAVNSNGQESITACI PKN3_Mmus RRVATDR-RHLGHVQQLLRASNRRLEQLHGELRELHAQVLLPASA--------E------ PKN2_Mmus RKVTTDK-KNLAYVDNILKKSNKKLEELHHKLQELNAHIVVSDPEDSTDCP-RT------ PKN1_Mmus RRATTDLGRSLAPVELLLRGSARRLDLLHQQLQELHAHVVLPDPAAGSDAT-QS------ F46F6.2_Cele KLITSDR-RQSEFLRYELSDLNEQIADLQEDLQALEMYNSGAFDEDVMYLD--------- PKN_Spur RQIPTGE-KEAGEVSDMGF---RRTSAVELQLTP-------------------------- AqueK022_Aque LKVTRDK-KARAHVGSILKTCTERIDQLRSDLTALLAQVPDE--EDATEVP--V------ . . : : : :. .* PKN3_Hsap -------------------PVASGPRPWAEQLRARHLEALRRQLHVELKVKQGAENMTHT PKN2_Hsap -------------------PDTPNNDPRCS-TSNNRLKALQKQLDIELKVKQGAENMIQM PKN1_Hsap -------------------PGA--GGPTCSATNLSRVAGLEKQLAIELKVKQGAENMIQT CG2049_Dmel DPNGGFLVSGAVGGLGGGNTALEGGAP--ATANDKVLASLEKQLQIEMKVKTGAENMIQS PKN3_Mmus -------------------PVTSEPQPRAEQSRARLSEALHRQLQVELKVKQGAENMIHT PKN2_Mmus -------------------PDTPNSDSRSS-TSNNRLMALQKQLDIELKVKQGAENMIQM PKN1_Mmus -------------------LAE--GSPICSSTNLSRVAGLEKQLAIELKVKQGAENMIQT F46F6.2_Cele --------------------NLED--CDVENGPPSKLVILQLELEKELKVKRGLEQFLR- PKN_Spur --------------------------------IEFRVEEVRHHYKVELALVEGFKNVIKM AqueK022_Aque -------------------PGSPP--AQRRSNQSQAITDLDRQLEIEQKVKAGAENMIKM : . * : * ::. : PKN3_Hsap CASG-TPKERKLLAAA-QQMLRDSQLKVALLRMKISSLEA-------------------- PKN2_Hsap YSNG-SSKDRKLHGTA-QQLLQDSKTKIEVIRMQILQAVQT---NELA------------ PKN1_Hsap YSNG-STKDRKLLLTA-QQMLQDSKTKIDIIRMQLRRALQA---GQLENQ---------- CG2049_Dmel LG---IGCDKKLLAEA-HQMLADSKAKIEFLRLRIIKVKQN---REQADRLKASRQMIDE PKN3_Mmus CASG-TPKERKLLAAA-QQMLKDSQLKVALLRMKISSLES-------------------- PKN2_Mmus YSNG-SSKDRKLHGTA-QQLLQDSKTKIEVIRMQILQAVQT---NELA------------ PKN1_Mmus YSNG-SSKDRKLLLTA-QQMLQDSKTKIDIIRMQLRRALQALQAGELESQ---------- F46F6.2_Cele ---G-APDKSKVHGDS-QSLLDDSRAKIAMLRMQIERLSQE---APAV-E---------- PKN_Spur YNNA-KTSDKKGLAERGFKLCHYGFRRTSAVELQ-------------------------- AqueK022_Aque YSNAKSSKDRKLLVEA-QQMYSDSRTKIEVLRMRIMKTKSA---LSSSPE---------- . * .: . : :.:: PKN3_Hsap -----------SGSPEP-GPELLAEELQHRLHVEAAVAEGAKNVVKLLS-SRRTQDRKAL PKN2_Hsap -------FD--NAKPVISPLELRMEELRHHFRIEFAVAEGAKNVMKLLG-SGKVTDRKAL PKN1_Hsap -----AAPDDTQGSPDLGAVELRIEELRHHFRVEHAVAEGAKNVLRLLS-AAKAPDRKAV CG2049_Dmel HGQTIGGNNSSQPQSLETTLEERIEELRHRLRIEAAVVDGAKNVIRTLQTANRAPDKKAL PKN3_Mmus -----------SGSPEP-GPDLLAEELQHRLRVEAAVAAGAKNVVKLLG-GQRMQDRKAL PKN2_Mmus -------FD--NAKPVISPLELRMEELRHHFKIEFAVAEGAKNVMKLLG-SGKVTDRKAL PKN1_Mmus -----AAPDEAQGDPELGAVELRIEELRHHFRVEHAVAEGAKNVLRLLS-GAKAPDRKAV F46F6.2_Cele ------------GEPK-TKVELAIDDLIIRFHKEKLIMDGSRNMIRILR-SKRKPDSKAV PKN_Spur ----------------LTPIEFRVEEVRHHYKVELALVEGFKNVIKMYN-NAKTSDKKGL AqueK022_Aque -----KGEDTHFGRNLLSKPEGRVSYIRYRIDVESRLIEGARKIMRA------NPNSKAY : . : : * : * ::::: : *. PKN3_Hsap AEAQAQLQESSQKLDLLRLALEQLLEQLPPAHPLRSRVTRELRAAV-PGY---------- PKN2_Hsap SEAQARFNESSQKLDLLKYSLEQRLNEVPKNHPKSRIIIEELSLVAASPTLSP---RQS- PKN1_Hsap SEAQEKLTESNQKLGLLREALERRLGELPADHPKGRLLREELAAA-SSAAFST---RLA- CG2049_Dmel QEAHGRLSESSRKLDLLRYSLDLRRQELPADSPAAQQLKTELQIVQLSTSPAP-VTYTSL PKN3_Mmus AEAQAQLQESSQKLDLLRLALELLLERLPPTHSLRSRVTQELWMAM-LGN---------- PKN2_Mmus SEAQARFNESSQKLDLLKYSLEQRLNELPRNHPKSSVVIEELSLV-ASPTLSP---RQS- PKN1_Mmus SEAQEKLTESNQKLGLLRESLERRLGELPADHPKGRLLREELTAA-SSSAFSA---ILP- F46F6.2_Cele DEAMNSYVIASEKADLIKLALLKYASSLPLEHDHRKYLIGEINSGL-IPKPPSLSQDRNS PKN_Spur AEAQKGLVEASHKLDILREGLEKRIQELPPDQTRFNQIKEELKSGK-I------------ AqueK022_Aque STAGENEKLSAQKLKLLKLSLENRLTEFPHLAEDSK------------EDPA-------- * : .* ::: .* .* PKN3_Hsap ------------PQPSGTPVKPTALTGTLQVRLLGCEQLLTAVPGRSPAAAL-------- PKN2_Hsap --------MISTQNQYSTLSKPAALTGTLEVRLMGCQDILENVPGRSKATSV-------- PKN1_Hsap --------GPFPATHYSTLCKPAPLTGTLEVRVVGCRDLPETIPWNPTPSM--------- CG2049_Dmel QSGQAGILGGKPYQSVSSLGRCASVTGKLEVRLLGCQDLLEDVPGRSRRDKD-------- PKN3_Mmus ------------PQPLGTLVKPIALTGTLQVRLLGCKDLLVAVPGRSPMAVL-------- PKN2_Mmus --------MLSTQNQYSTLSKPAALTGTLEVRLMGCQDILENVPGRSKATSV-------- PKN1_Mmus --------GPFPATHYSTLSKPAPLTGTLEVRVVGCKNLPETIPWSPPPSV--------- F46F6.2_Cele PSSEDGGNGTSTSRRCSFMPYSLQISGCLEVTINGCAGILSEVFERKIRK---------- PKN_Spur -------------KSDNPLPKPAALTGVLEVRIMGCQDLQEMIPYRARNSIT-------- AqueK022_Aque ---------------SILIPRPAQLTGTLTIKLLGCEGLVDIVTLRMNYGLDTLSSHTRP ::* * : : ** : : PKN3_Hsap ----------------------------------AS-SPS-----EGW-----L------ PKN2_Hsap --------------------------------ALPGWSPS-----ETR--SSFMSRT--- PKN1_Hsap --------------------------------GGPG-TP------DSR--PPFLSRPARG CG2049_Dmel ---------------------------------NNS-SPG-----DLR--SFV-----KG PKN3_Mmus ----------------------------------AG-SPS-----ESW-----L------ PKN2_Mmus --------------------------------ALPGWSPS-----DNR--SSFMSRT--- PKN1_Mmus --------------------------------GASG-TP------ESR--TPFLSRPARG F46F6.2_Cele --------------------------------DVPG-VPGFIS-------VYG------- PKN_Spur ---------------------------------SLN-SPS-----ESK--GGILR----G AqueK022_Aque TTGSLLSHIMTLPRSHRSNSTPQADLERDLESSAPT-TSGYSSSTMAWNRPRGGSRHNKL . PKN3_Hsap ---RT---KAKHQR-GRGELASEVLAVLKVDNRVVGQTGWGQVAEQSWDQTFVIPLERAR PKN2_Hsap --SKSKSGSSRNLLK-TDDLSNDVCAVLKLDNTVVGQTSWKPISNQSWDQKFTLELDRSR PKN1_Hsap LYSRSGSLSGRSSLKAEAENTSEVSTVLKLDNTVVGQTSWKPCGPNAWDQSFTLELERAR CG2049_Dmel VTSRSS---SKSYS-VKDETSIEIMAVIKLDNITVGQTSWKQCSQQAWDQRFSIDLDRSR PKN3_Mmus ---RT---RSRQQR-GGGELASEVLAVLKVDNRVVGQTGWGLVAEKSWDQSFIISLDRAR PKN2_Mmus --SKSKSGSSRNLLK-TDDLSNDVCAVLKLDNTVVGQTSWKPISNQSWDQKFTLELDRSR PKN1_Mmus LYSRSGSLSGRSSLRGEAENATEVSTVLKLDNTVVGQTAWKPCGPNAWDQSFTLELERAR F46F6.2_Cele ---MDASGKKKKSAR-GPNSSEEVFCVLRIDNRFIGATELRKIVDRNWDQKFDVDLDRSR PKN_Spur KASFHGRSSSRSSS-TKEEISNEISAIMKLDSVLVGQTPFKPISNQCWDQKFLFNLDKAR AqueK022_Aque KGSLSKQPSAQDLLD-DALPGGTICAVLSMDNKEVGRTKWSPPSNTAWEQQYRLELDRNR : : :: :*. :* * *:* : . *:: * PKN3_Hsap ELEIGVHWRDW--RQLCGVAFLRLEDFLDNA-CHQLSLSLVPQGLLFAQVTFCDPVIE-R PKN2_Hsap ELEISVYWRDW--RSLCAVKFLRLEDFLDNQ-RHGMCLYLEPQGTLFAEVTFFNPVIE-R PKN1_Hsap ELELAVFWRDQ--RGLCALKFLKLEDFLDNE-RHEVQLDMEPQGCLVAEVTFRNPVIE-R CG2049_Dmel ELEIGVYWRDW--RSLCAVKVLRLEEFIDDV-RHGMALQLEPQGLLFAEVKFLNPMIS-Q PKN3_Mmus ELEIGVHWRDW--RQLCGVAFLKLEDFLDNA-CHQLSLSLVPQGRLFAQVTFCEPVIE-R PKN2_Mmus ELEISVYWRDW--RSLCAVKFLRLEDFLDNQ-RHGMCLYLEPQGTLFAEVTFFNPVIE-R PKN1_Mmus ELELAVFWRDQ--RGLCALKFLKLEDFLDNE-RHEVQLDMEPQGCLVAEVTFRNPIIE-R F46F6.2_Cele ELQIELFYHDD--RSMCGFAAVKLSNLIETSSKVGIIVPVEPQGNIFVQFKYMNPVVS-R PKN_Spur ELEINVRWKDQ--RSLCAVKFLRLEDFLDNQ-RHGMCLNLEPEGLLFTEITFTTPVIE-R AqueK022_Aque ELEICVRYRDDEGESLCGVLYLRLEDFLSTP-SSILCIPMEPQGILLAEISYEDPKTELR **:: : ::* . :*.. ::*.:::. : : : *:* :..:..: * . : PKN3_Hsap RPRLQRQERIFSKRRGQDFLRASQMNLGMAAWGRLVMNLL-PPCSSPSTISPPKGCPRTP PKN2_Hsap RPKLQRQKKIFSKQQGKTFLRAPQMNINIATWGRLVRRAI-PTVNHSGTFSPQAPVPTTV PKN1_Hsap IPRLRRQKKIFSKQQGKAFQRARQMNIDVATWVRLLRRLI-PNATGTGTFSPGASPGSEA CG2049_Dmel KPKLRRQRMIFNRQQAKNISRAKQMNINVATWGRLLKRNA-PNHVHMGSAGSGSSLTGSS PKN3_Mmus RPRLQRQRCIFSKRRGRDFMRASQMNLSMAAWGRLVMSLL-PPCSSPNTASPPKGRPSTA PKN2_Mmus RPKLQRQKKIFSKQQGKTFLRAPQMNINIATWGRLVRRAI-PTVNHSGTFSPQTPVPATV PKN1_Mmus IPRLQRQKKIFSKQQGKAFQRARQMNIDVATWVRLLRRLI-PSAVATGTFSPNASPGAEI F46F6.2_Cele KPKLERQRRLFRVKE---SNDGARQKLGVFAFSRLIKNRGNEPSEKFAAFTG-FTPMPSS PKN_Spur RTKLRRQRKIFPKHKGKNFLRAGQMNINVATWGRLMKRSI-PSSLTPSGTSPPTAIRPRP AqueK022_Aque QPKLKRNRKIFKGGK---ILRPSEINTNIATWSRLLSRAA-PAITAGADLASPMGGASGA .:*.*:. :* . . : .: :: **: PKN3_Hsap -----------------TTL-REA-----------SDPATP------------------- PKN2_Hsap -----------------PVVDVRI-----------PQLAPP-A----------------- PKN1_Hsap R----------------TTGDISV-----------EKLNLGTD----------------- CG2049_Dmel PMVVGGSRDSESPISRTPSSDALVEPEPYTPGEQAQNLEFDPDAGINEHVETPGEYPDPA PKN3_Mmus -----------------V---CGT-----------PSAASP------------------- PKN2_Mmus -----------------PVVDARI-----------PDLAPP-A----------------- PKN1_Mmus R----------------HTGDISM-----------EKLNLGAD----------------- F46F6.2_Cele S------------------SQHQP-----------GT----------------------- PKN_Spur -----------------PI----------------QRLSFGEA----------------- AqueK022_Aque K----------------SSGNLKP-----------VTLNFDS------------------ PKN3_Hsap ------------------------------------------------SNFLPKKTPLGE PKN2_Hsap ------------------------------------------------SDSTVTKLDFDL PKN1_Hsap ------------------------------------------------SDSSPQK----- CG2049_Dmel ASGLSGMRPLSMHMQGISVLPPESPPVATGAAGRPNTLSLQMPGASKGQVIQGGRTAA-P PKN3_Mmus ------------------------------------------------SNFLPMKTLSKE PKN2_Mmus ------------------------------------------------SDSTVTKLDFDL PKN1_Mmus ------------------------------------------------SDSSSQK----- F46F6.2_Cele -------------------------------------------------SSSGPSTSSSI PKN_Spur ------------------------------------------------DSSESAGS--NS AqueK022_Aque -------------------------------------------------DTSPPQSDSQS PKN3_Hsap EMTPPPKPPRLYLPQEPTS----------------------------------------- PKN2_Hsap EPEPPPAPPRASSLGEIDESSELRVLDIPGQDSETVFDIQNDRNSI-------------- PKN1_Hsap --SSRDPPSSPSSLSS-------------------------------------------- CG2049_Dmel TTAPPP-PPVLKA------TSTTPILDQELQDALHEFDFLSDLDSRPTTLRRLLKEQKMA PKN3_Mmus DTKPPPKPPRLYL-QEPA------------------------------------------ PKN2_Mmus EPEPPPAPPRASSLGETDESSELRVLDIPGQGSETVFNIENDRNNL-------------- PKN1_Mmus --SPPGLPSTSCSLSS-------------------------------------------- F46F6.2_Cele --ASTPTPSTSNSL----------------------FDKV-------------------- PKN_Spur QEGGAGSPSK------------DKMGGVEVQDALSSFDFLNNSSSS-------------- AqueK022_Aque GENSPKTPDTPSSYR--------------HQSHTSVFDKD-DDGGV-------------- * PKN3_Hsap ------------------------------------------------------------ PKN2_Hsap ------------------------------------------------------------ PKN1_Hsap ------------------------------------------------------------ CG2049_Dmel LDAGALENLLLQQQQTEQQALQQRQRQEQLRLQQFQEAQRQAILDLCVKQREPAEQTSPT PKN3_Mmus ------------------------------------------------------------ PKN2_Mmus ------------------------------------------------------------ PKN1_Mmus ------------------------------------------------------------ F46F6.2_Cele ------------------------------------------------------------ PKN_Spur ------------------------------------------------------------ AqueK022_Aque ------------------------------------------------------------ PKN3_Hsap ------------------------------------------------------------ PKN2_Hsap ----------------------------LPKS---------------------------- PKN1_Hsap -----------------------------PIQ---------------------------- CG2049_Dmel LANQTPTFPPLASNQIMPSLNARPCQSQSPNH-------------------NEFQLQPQP PKN3_Mmus ------------------------------------------------------------ PKN2_Mmus ----------------------------RPKS---------------------------- PKN1_Mmus -----------------------------PTH---------------------------- F46F6.2_Cele --------------------------------SNHLPSFNPRKSAKKREAREAAAVAPMT PKN_Spur ----------------------------SPKV---------------------------- AqueK022_Aque ----------------------------APETNGPLPPPSPVSDAELMHTPDQI-IIPPP PKN3_Hsap ------------------------------------------------------------ PKN2_Hsap ------------------------------------------------------------ PKN1_Hsap ------------------------------------------------------------ CG2049_Dmel PHPA-------------------------------------------------------- PKN3_Mmus ------------------------------------------------------------ PKN2_Mmus ------------------------------------------------------------ PKN1_Mmus ------------------------------------------------------------ F46F6.2_Cele AAVA------------------------------------------------------AV PKN_Spur ------------------------------------------------------------ AqueK022_Aque PQFVEDKTTPTKGGASGERRLSNGVVEPLRPPSPLPELCKHIPYLDNLGKHEDGLNIAYS PKN3_Hsap --------------EETPRT--------------------KRPHME-PRTRRG------- PKN2_Hsap -----------------QSE--------------------YKPDTP-QSGLEY------- PKN1_Hsap -----------------ES---------------------TAPELP-SETQET------- CG2049_Dmel -----------------QKP--------------------TNPEPP-SAVEQQLHRPVLI PKN3_Mmus --------------PGTPCT--------------------KRPHMD-PRPAVV------- PKN2_Mmus -----------------KSE--------------------YELSIP-DSGRSC------- PKN1_Mmus -----------------EST--------------------TSPELP-SETQET------- F46F6.2_Cele N----------LNAPSTSNSMQPSTQERNLVVDEFPTDRS----G-PSQAPPV------- PKN_Spur -----------------SSPLTPP------------AARSSPPPSPLSQTQGQ------- AqueK022_Aque HPPAPPVPPRNYQLPNNTHQKVGRMSTE-----GTSV---------SASGTPE------- PKN3_Hsap ------------------------------------------------------------ PKN2_Hsap ------------------------------------------------------------ PKN1_Hsap ------------------------------------------------------------ CG2049_Dmel LPPVVLLGGREEDRSVPPSPLVEYPEDDDEYLYRGSNENLGTRLHSSHSSSAGDRFCVEV PKN3_Mmus ------------------------------------------------------------ PKN2_Mmus ------------------------------------------------------------ PKN1_Mmus ------------------------------------------------------------ F46F6.2_Cele ------------------------------------------------------------ PKN_Spur ------------------------------------------------------------ AqueK022_Aque ------------------------------------------------------------ PKN3_Hsap --------------------------------------------P-S------------- PKN2_Hsap --------------------------------------------S-GI-Q-E-------- PKN1_Hsap --------------------------------------------P-GP-A-L-------- CG2049_Dmel IPQLGKLYVGSSQQQYAQQSSPIIQEPATPTIYGNSAAAGAPQFP-QP-A-QRQEKQPPQ PKN3_Mmus --------------------------------------------P-A------------- PKN2_Mmus --------------------------------------------W-GV-G-E-------- PKN1_Mmus --------------------------------------------P-GP-G-L-------- F46F6.2_Cele --------------------------------------------P-AV-R-H-------- PKN_Spur --------------------------------------------H-GA-Q-E-------- AqueK022_Aque --------------------------------------------RKGTSSSY-------- PKN3_Hsap ------------------------------------------------------------ PKN2_Hsap -------------------------------------------------------LE--- PKN1_Hsap ------------------------------------------------------------ CG2049_Dmel QQPIYANQYELNVAKAAAAASVYSPSSSTTSNSNQQQQQQRRNVARGLQYRESGGLETGR PKN3_Mmus ------------------------------------------------------------ PKN2_Mmus -------------------------------------------------------LD--- PKN1_Mmus ------------------------------------------------------------ F46F6.2_Cele -------------------------------------------------------ID--- PKN_Spur ------------------------------------------------------------ AqueK022_Aque -------------------------------------------------------RD--- PKN3_Hsap -PPASPTRKPPRLQDFRCLAVLGRGHFGKVLLVQFKGTGKYYAIKALKKQEVLSRDEIES PKN2_Hsap -DRRSQQRFQFNLQDFRCCAVLGRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDS PKN1_Hsap --CSPLRKSPLTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVES CG2049_Dmel AGKQPPNAGMLSMDNFRLLSVLGRGHFGKVILSQLRSNNQYYAIKALKKGDIIARDEVES PKN3_Mmus -LAALSTRKPPRLQDFRCLAVLGRGHFGKVLLVQYKGTGKYYAIKALKKQEVLGRDEIDS PKN2_Mmus -DKRAQQRFQFSLQDFRCCAVLGRGHFGKVLLAEYKHTNEMFAIKALKKGDIVARDEVDS PKN1_Mmus --CSPLRKSPLTLEDFKFLAVLGRGHFGKVLLSEFRSSGELFAIKALKKGDIVARDEVES F46F6.2_Cele -FFASSDGAPLTVEQFRLISVLGRGHFGKVILSQHNPTSNYYALKVLKKGDILGRDEVES PKN_Spur -ISAMDDGTLMTLENFRLISVLGRGHFGKVLLTEYKTTGEFFAIKALKKRDVVAREEVES AqueK022_Aque -TGGSVLPHMKGINEYKFIAVLGRGHFGKVLLAEDKNTKELVAVKVLKKGDIISRDEVES ::::: :**********:* : . . : *:*.*** :::.*:*::* PKN3_Hsap LYCEKRILEAVGCTGHPFLLSLLACFQTSSHACFVTEFVPGGDLMMQIHEDVFPEPQARF PKN2_Hsap LMCEKRIFETVNSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHTDVFSEPRAVF PKN1_Hsap LMCEKRILAAVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHSDVFSEPRAIF CG2049_Dmel LLSEKRIFEVANAMRHPFLVNLYSCFQTEQHVCFVMEYAAGGDLMMHIHTDVFLEPRAVF PKN3_Mmus LYCEKRILETVGRTGHPFLLSLLACLQTSSHACFVTEFLPGGDLMAQIHEDVFPEPQACF PKN2_Mmus LMCEKRIFETVNSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHTDVFSEPRAVF PKN1_Mmus LMCEKRILAAVTRAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHSDVFSEPRAVF F46F6.2_Cele LMVEKRIFEVSSRARHPFLVNLNGCFQTNEHVFFCMEYSMGGDLMRHIHDDVFDEVRGCF PKN_Spur LMCEKRIFEAANSIRHPFLVNLFACFQTEHHVCFVMEYAMGGDLMMHIHNDVFTEPRTVF AqueK022_Aque LMSEKRIFEKINAVRHPFLVNLHCCFQSENNVCFVMEYACGGDLMMHIHQDIFKEPRACF * ****: ****:.* *:*: :. * *: ***** :** *:* * : * PKN3_Hsap YVACVVLGLQFLHEKKIIYRDLKLDNLLLDAQGFLKIADFGLCKEGIGFGDRTSTFCGTP PKN2_Hsap YAACVVLGLQYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTP PKN1_Hsap YSACVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTP CG2049_Dmel YAACVVLGLQYLHENKIIYRDLKLDNLLLDTEGYVKIADFGLCKEGMGFGDRTGTFCGTP PKN3_Mmus YLACVVLGLQFLHEKRIIYRDLKLDNLLLDAQGFLKIADFGLCKEGIGFGDRTSTFCGTP PKN2_Mmus YAACVVLGLQYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTP PKN1_Mmus YSACVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTP F46F6.2_Cele YAACVVLGLDFLHKHNIIYRDIKLDNLLLDREGYVKIADFGLCKENMGPFDKTSTFCGTP PKN_Spur YSACVVLGLQYLHENKIVYRDLKLDNLLLDQDGFLKIADFGLCKEGMGYGDRTSTFCGTP AqueK022_Aque YAACVVLGLQYLHENGIVYRDLKLDNLLLDVDGFVKVADFGLCKEGMWYGSRTSTFCGTP * *******::**:: *:***:******** :*::*:********.: .:*.****** PKN3_Hsap EFLAPEVLTQEAYTRAVDWWGLGVLLYEMLVGECPFPGDTEEEVFDCIVNMDAPYPGFLS PKN2_Hsap EFLAPEVLTETSYTRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLS PKN1_Hsap EFLAPEVLTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLS CG2049_Dmel EFLAPEVLTETSYTRAVDWWGLGVLIFEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLS PKN3_Mmus EFLAPEVLTQEAYTRAVDWWGLGVLLYEMLVGECPFPGDTEEEVFECIVSADVPCPHFLS PKN2_Mmus EFLAPEVLTETSYTRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLS PKN1_Mmus EFLAPEVLTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLS F46F6.2_Cele EFLAPEVLSDSSYTRAIDWWGLGVLIFEMLVGEPPFSGDDEEEIFDSIISEDVRYPRYLS PKN_Spur EFLAPEVLTEPYYTRAVDWWGLGVLIFEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLS AqueK022_Aque EFLAPEVLTDVSYTRAVDWWGLGVLIYEMLVGESPFPGEDEEEVFDSIVNDDVRYPRFLS ********:: ****:********::****** **.*: ***:*:.*:. :. * :** PKN3_Hsap VQGLEFIQKLLQKCPEKRLGAGEQDAEEIKVQPFFRTTN--WQALLARTIQPPFVPTLCG PKN2_Hsap TEAISIMRRLLRRNPERRLGASEKDAEDVKKHPFFRLID--WSALMDKKVKPPFIPTIRG PKN1_Hsap AEAIGIMRRLLRRNPERRLGSSERDAEDVKKQPFFRTLG--WEALLARRLPPPFVPTLSG CG2049_Dmel LEAIAVMRRLLRKNPERRLGSSERDAEDVKKQAFFRSIV--WDDLLLRKVKPPFVPTINH PKN3_Mmus VQGLELIQKLLQKSPEKRLGAGERDAEEIKVQPFFRTTN--WQALLARTVQPPFVPTLCG PKN2_Mmus TEAISIMRRLLRRNPERRLGAGEKDAEDVKKHPFFRLTD--WSALMDKKVKPPFVPTIRG PKN1_Mmus AEAIGIMRRLLRRNPERRLGSTERDAEDVKKQPFFRSLG--WDVLLARRLPPPFVPTLSG F46F6.2_Cele VESIAIMRRLLRKVPEKRLGYGERDAEDIKIQRFFRHISWEWDKLLNREIRPPFQPQIRN PKN_Spur TEAVAIMRRLLRRNPMRRLGSSQRDAEDIKMQGFFRNIN--WDDLLMRRVTPAFVPKIAN AqueK022_Aque SEAISIMRKLLRRNPERRLGAGERDAEDIKRQPFFKHID--WEKLLRREVKPPFKPKLEG :.: .:::**:: * :*** ::***::* : **: *. *: : : *.* * : PKN3_Hsap PADLRYFEGEFTGLPPALTPPAPHSLLTARQQAAFRDFDFVSERFLEP PKN2_Hsap REDVSNFDDEFTSEAPILTPPREPRILSEEEQEMFRDFDYIADW---C PKN1_Hsap RTDVSNFDEEFTGEAPTLSPPRDARPLTAAEQAAFLDFDFVAGG---C CG2049_Dmel LEDVSNFDEEFTSEKAQLTPPKEPRHLTEEEQLLFQDFSYTAEW---C PKN3_Mmus PADLRYFEGEFTSLPPTLTPPVSQSSLTARQQAAFRDFDFVSEQFLES PKN2_Mmus REDVSNFDDEFTSEAPILTPPREPRILLEEEQEMFHDFDYVADW---C PKN1_Mmus RTDVSNFDEEFTGEAPTLSPPRDARPLTAAEQAAFRDFDFVAGG---Y F46F6.2_Cele PEDVSNFDLEFTQEKARFSAASSTRPITEADQRLFNNFDFSI-V---P PKN_Spur SEDVSNFDEEFTAEHPVLTPAKDPRELTDEEQEHFKDFNYIADW---C AqueK022_Aque RLDISNFDDEFTREDPIFTPPKNPRPLKAKEQKLFRGFEYSADWS-VI *: *: *** . ::.. : :* * .*.: