CLUSTAL W (1.83) multiple sequence alignment PLK4_Hsap_SAK MATC-------------------------------------------------------- PLK3_Hsap_PLK2 MEPAAGF-----------------L--S-P------------------------------ PLK2_Hsap_PLK2 MELLRTI-----------------T--YQPA-AST------K------------------ PLK1_Hsap_PLK1 MSAAVTA-----------------G--K-L------------------------------ polo_Dmel_PLK1 MAAKPED-----------------K----------------------------------- SAK_Dmel_SAK MLSNRA------------------------------------------------------ PLK5_Mmus_PLK2 MEPRSRR----------------------------------------------------- PLK4_Mmus_SAK MAAC-------------------------------------------------------- PLK3_Mmus_PLK2 MEPAAGF-----------------L--S-P------------------------------ PLK2_Mmus_PLK2 MELLRTI-----------------T--YQPA-AGT------K------------------ PLK1_Mmus_PLK1 MNAAAKA-----------------G--K-L------------------------------ plk-2_Cele_PLK1 MQRVQPS-----------------A----------------------------------- plk-1_Cele_PLK1 MNRLPNI-----------------A--K-P------------------------------ F55G1.8_Cele_PLK1 MQHVLRT-----------------R----------------------------------- CDC5_Scer_PLK1 MSLGPLK-----------------AIND------------------------KQLNTRSK zyg-1_Cele_SAK MSGGKSG----------------------------------------------------- PLK_Ddis_PLK1 MVSINQN-----------------F--KLPI-SMNSQ-------PIQ--IQQQQFK---- 8635_Tthe_SAK MQGLA------------------------------------------------------- 18358b_Tthe_PLK-Unclassified ------------------------------------------------------------ 18380_Tthe_PLK-Unclassified MSYFKNI-----------------F--KLRLRDFDKEGVVVFLVEVQLTVENKQFM---- 21183_Tthe_SAK MIQQK------------------------------------------------------- 22503_Tthe_PLK-Unclassified MSTEN------------------------------------------------------- 5034_Tthe_SAK MFSQE------------------------------------------------------- 8829_Tthe_PLK-Unclassified MDKAN------------------------------------------------------- SAK_Spur_SAK ME---------------------------------------------------------- PLK1_Spur_PLK1 MASRHKE-----------------D----------------------------------- PLK2_Spur_PLK2 MPLTRSPVLPVGLSKDVRYTMDQLQ--K-P------------------------------ n1170_Tthe_PLK-Unclassified MSNQD------------------------------------------------------- n808_Tthe_PLK-Unclassified MSNQD------------------------------------------------------- CC1G_07437_Ccin_PLK1 MYQMNGY-----------------R--M-P------------------------------ AqueK200_Aque_PLK1 MAHHLSE-----------------K--D-K------------------------------ AqueK201_Aque_SAK ------------------------------------------------------------ GK066_Glam_PLK-Unclassified MSHSNAP----------------------------------------------------- PLK4_Hsap_SAK ------------------------------------------------------------ PLK3_Hsap_PLK2 ---------------------RP------------------------------------- PLK2_Hsap_PLK2 MCE------------------QA-----------LGKGCGA------------------- PLK1_Hsap_PLK1 ------------------------------------------------------------ polo_Dmel_PLK1 ------------------------------------------------------------ SAK_Dmel_SAK ------------------------------------------------------------ PLK5_Mmus_PLK2 ------------------------------------------------------------ PLK4_Mmus_SAK ------------------------------------------------------------ PLK3_Mmus_PLK2 ---------------------RP------------------------------------- PLK2_Mmus_PLK2 MCE------------------QA-----------LGKACGG------------------- PLK1_Mmus_PLK1 ------------------------------------------------------------ plk-2_Cele_PLK1 ------------------------------------------------------------ plk-1_Cele_PLK1 ------------------------------------------------------------ F55G1.8_Cele_PLK1 ------------------------------------------------------------ CDC5_Scer_PLK1 LVHTPIKGNTADLVGKENHFKQTKRLDPNND----------------------------- zyg-1_Cele_SAK ------------------------------------------------------------ PLK_Ddis_PLK1 -QP------------------QQ-------QPQQKSNSCFSDQENYPANIQPSSSTSSSS 8635_Tthe_SAK ------------------------------Q----------------------------- 18358b_Tthe_PLK-Unclassified ------------------------------------------------------------ 18380_Tthe_PLK-Unclassified -SQ------------------QA-------A----------------------------- 21183_Tthe_SAK ------------------------------K----------------------------- 22503_Tthe_PLK-Unclassified ------------------------------Q----------------------------- 5034_Tthe_SAK ------------------------------E----------------------------- 8829_Tthe_PLK-Unclassified ------------------------------E----------------------------- SAK_Spur_SAK ------------------------------------------------------------ PLK1_Spur_PLK1 ------------------------------------------------------------ PLK2_Spur_PLK2 ------------------------------------------------------------ n1170_Tthe_PLK-Unclassified ------------------------------K----------------------------- n808_Tthe_PLK-Unclassified ------------------------------K----------------------------- CC1G_07437_Ccin_PLK1 ------------------------------------------------------------ AqueK200_Aque_PLK1 ------------------------------------------------------------ AqueK201_Aque_SAK ------------------------------------------------------------ GK066_Glam_PLK-Unclassified ------------------------------------------------------------ PLK4_Hsap_SAK ------------------------------------------------------------ PLK3_Hsap_PLK2 ---------------------F----------------------------------QRA- PLK2_Hsap_PLK2 ---------------------D----------------------------------SKK- PLK1_Hsap_PLK1 ----------------------------------------------------------A- polo_Dmel_PLK1 ------------------------------------------------------------ SAK_Dmel_SAK ------------------------------------------------------------ PLK5_Mmus_PLK2 ------------------------------------------------------------ PLK4_Mmus_SAK ------------------------------------------------------------ PLK3_Mmus_PLK2 ---------------------F----------------------------------PRA- PLK2_Mmus_PLK2 ---------------------D----------------------------------SKK- PLK1_Mmus_PLK1 ----------------------------------------------------------A- plk-2_Cele_PLK1 ----------------------------------------------------------A- plk-1_Cele_PLK1 ----------------------------------------------------------P- F55G1.8_Cele_PLK1 ----------------------------------------------------------G- CDC5_Scer_PLK1 --------------------------------------------------------HHH- zyg-1_Cele_SAK ------------------------------------------------------------ PLK_Ddis_PLK1 SSSIHITKSMVIRPPLESNQPQPQQQQQQQQTLQQIHHQQVQLQQQQSLQMQQQQLQQQ- 8635_Tthe_SAK --------------------------------------------------------TPFD 18358b_Tthe_PLK-Unclassified ------------------------------------------------------------ 18380_Tthe_PLK-Unclassified --------------------------------------------------------QQQ- 21183_Tthe_SAK --------------------------------------------------------DQK- 22503_Tthe_PLK-Unclassified --------------------------------------------------------NQQ- 5034_Tthe_SAK --------------------------------------------------------AKE- 8829_Tthe_PLK-Unclassified --------------------------------------------------------GKD- SAK_Spur_SAK ------------------------------------------------------------ PLK1_Spur_PLK1 ------------------------------------------------------------ PLK2_Spur_PLK2 ----------------------------------------------------------A- n1170_Tthe_PLK-Unclassified --------------------------------------------------------QQQ- n808_Tthe_PLK-Unclassified --------------------------------------------------------QQQ- CC1G_07437_Ccin_PLK1 ----------------------------------------------------------P- AqueK200_Aque_PLK1 ----------------------------------------------------------L- AqueK201_Aque_SAK ------------------------------------------------------------ GK066_Glam_PLK-Unclassified ------------------------------------------------------------ PLK4_Hsap_SAK ------------------------------------------------------------ PLK3_Hsap_PLK2 ---A--AAPAPPA-------------------GPGP------------------------ PLK2_Hsap_PLK2 ---K--RPPQPPE-------------------ESQP------------------------ PLK1_Hsap_PLK1 ---R--APADPGK-------------------AGVP------------------------ polo_Dmel_PLK1 ------------------------------------------------------------ SAK_Dmel_SAK ------------------------------------------------------------ PLK5_Mmus_PLK2 ------------------------------------------------------------ PLK4_Mmus_SAK ------------------------------------------------------------ PLK3_Mmus_PLK2 ---A--APSAPPA-------------------GPGP------------------------ PLK2_Mmus_PLK2 ---K--RPQQPSE-------------------DGQP------------------------ PLK1_Mmus_PLK1 ---R--APADLGK-------------------GGVP------------------------ plk-2_Cele_PLK1 ---R--VKSQ-------------------------------------------------- plk-1_Cele_PLK1 ---Q--KSNQ-------------------------------------------------- F55G1.8_Cele_PLK1 ---N--SAQDKNK----------------------------------------------- CDC5_Scer_PLK1 ---Q--PAQKKKR----------------------------------------------- zyg-1_Cele_SAK ------------------------------------------------------------ PLK_Ddis_PLK1 ---Q--QQ-QQQQ-------------------QMPP------------------------ 8635_Tthe_SAK LFEPQQRLFRLPQ-------------------KKSGVLKQQIFKEFIEKAQIKIKILDEE 18358b_Tthe_PLK-Unclassified ------------------------------------------------------------ 18380_Tthe_PLK-Unclassified ---P--QQ-KQSE-------------------QGQN------------------------ 21183_Tthe_SAK ---P--KSSS--Q-------------------Q--------------------------- 22503_Tthe_PLK-Unclassified ---Q--KPAQDPV-------------------SCY------------------------- 5034_Tthe_SAK ---Q--NSDEQNQ-------------------E--------------------------- 8829_Tthe_PLK-Unclassified ---Q-------------------------------------------------------- SAK_Spur_SAK ------------------------------------------------------------ PLK1_Spur_PLK1 ------------------------------------------------------------ PLK2_Spur_PLK2 ---P-LSPEDTPKTTPS---LSSKPHGAGREENVKP------------------------ n1170_Tthe_PLK-Unclassified ---Q--QQ-QQPQ-------------------GAQR------------------------ n808_Tthe_PLK-Unclassified ---Q--QQ-QQPQ-------------------GAQR------------------------ CC1G_07437_Ccin_PLK1 ---A--APGPSSKRNPLVNAVNHHPNV--MQMNAVP------------------------ AqueK200_Aque_PLK1 ---G--S----------------------------------------------------- AqueK201_Aque_SAK ------------------------------------------------------------ GK066_Glam_PLK-Unclassified ------------------------------------------------------------ PLK4_Hsap_SAK ------------------------------------------------------------ PLK3_Hsap_PLK2 ------------------------------------------------------------ PLK2_Hsap_PLK2 ------------------------------------------------------------ PLK1_Hsap_PLK1 ------------------------------------------------------------ polo_Dmel_PLK1 ------------------------------------------------------------ SAK_Dmel_SAK ------------------------------------------------------------ PLK5_Mmus_PLK2 ------------------------------------------------------------ PLK4_Mmus_SAK ------------------------------------------------------------ PLK3_Mmus_PLK2 ------------------------------------------------------------ PLK2_Mmus_PLK2 ------------------------------------------------------------ PLK1_Mmus_PLK1 ------------------------------------------------------------ plk-2_Cele_PLK1 ------------------------------------------------------------ plk-1_Cele_PLK1 ------------------------------------------------------------ F55G1.8_Cele_PLK1 ------------------------------------------------------------ CDC5_Scer_PLK1 ------------------------------------------------------------ zyg-1_Cele_SAK ------------------------------------------------------------ PLK_Ddis_PLK1 ------------------------------------------------------------ 8635_Tthe_SAK NDNEVLFYTPILFGYLSLIILKESSSTIILKHTLCYCNGKPYLIKDHQIRLLFTRCLNKI 18358b_Tthe_PLK-Unclassified ------------------------------------------------------------ 18380_Tthe_PLK-Unclassified ------------------------------------------------------------ 21183_Tthe_SAK ------------------------------------------------------------ 22503_Tthe_PLK-Unclassified ------------------------------------------------------------ 5034_Tthe_SAK ------------------------------------------------------------ 8829_Tthe_PLK-Unclassified ------------------------------------------------------------ SAK_Spur_SAK ------------------------------------------------------------ PLK1_Spur_PLK1 ------------------------------------------------------------ PLK2_Spur_PLK2 ------------------------------------------------------------ n1170_Tthe_PLK-Unclassified ------------------------------------------------------------ n808_Tthe_PLK-Unclassified ------------------------------------------------------------ CC1G_07437_Ccin_PLK1 ------------------------------------------------------------ AqueK200_Aque_PLK1 ------------------------------------------------------------ AqueK201_Aque_SAK ------------------------------------------------------------ GK066_Glam_PLK-Unclassified ------------------------------------------------------------ PLK4_Hsap_SAK ------------------------------------------------------------ PLK3_Hsap_PLK2 ------------P--P-------------------------------------------- PLK2_Hsap_PLK2 ------------P--Q-------------------------------------------- PLK1_Hsap_PLK1 ---------------G-------------------------------------------- polo_Dmel_PLK1 ------------------------------------------------------------ SAK_Dmel_SAK ------------------------------------------------------------ PLK5_Mmus_PLK2 ------------------------------------------------------------ PLK4_Mmus_SAK ------------------------------------------------------------ PLK3_Mmus_PLK2 ------------P--A-------------------------------------------- PLK2_Mmus_PLK2 ---------------Q-------------------------------------------- PLK1_Mmus_PLK1 ---------------G-------------------------------------------- plk-2_Cele_PLK1 ------------------------------------------------------------ plk-1_Cele_PLK1 ------------------------------------------------------------ F55G1.8_Cele_PLK1 ------------------------------------------------------------ CDC5_Scer_PLK1 ------------------------------------------------------------ zyg-1_Cele_SAK ------------------------------------------------------------ PLK_Ddis_PLK1 ------------P--QS------------------------------------------- 8635_Tthe_SAK NNIEKFSKYAMNP--RNGEISLKDALFFEKETFQKFNESPLLAIKPMLELYNQQIHILKQ 18358b_Tthe_PLK-Unclassified ------------------------------------------------------------ 18380_Tthe_PLK-Unclassified ------------N--NN------------------------------------------- 21183_Tthe_SAK ------------------------------------------------------------ 22503_Tthe_PLK-Unclassified ------------------------------------------------------------ 5034_Tthe_SAK ------------------------------------------------------------ 8829_Tthe_PLK-Unclassified ------------------------------------------------------------ SAK_Spur_SAK ------------------------------------------------------------ PLK1_Spur_PLK1 ------------------------------------------------------------ PLK2_Spur_PLK2 ------------PIPP-------------------------------------------- n1170_Tthe_PLK-Unclassified ------------------------------------------------------------ n808_Tthe_PLK-Unclassified ------------------------------------------------------------ CC1G_07437_Ccin_PLK1 ------------PVPA-------------------------------------------- AqueK200_Aque_PLK1 ------------------------------------------------------------ AqueK201_Aque_SAK ------------------------------------------------------------ GK066_Glam_PLK-Unclassified ------------------------------------------------------------ PLK4_Hsap_SAK ------------------------------------------------------------ PLK3_Hsap_PLK2 -----------SA----LR----------------------------------------- PLK2_Hsap_PLK2 -----------SQ-AQVPP----------------------------------------- PLK1_Hsap_PLK1 -----------VA----AP----------------------------------------- polo_Dmel_PLK1 ------------------------------------------------------------ SAK_Dmel_SAK ------------------------------------------------------------ PLK5_Mmus_PLK2 ------------------------------------------------------------ PLK4_Mmus_SAK ------------------------------------------------------------ PLK3_Mmus_PLK2 -----------NA----SP----------------------------------------- PLK2_Mmus_PLK2 --------------AQVTP----------------------------------------- PLK1_Mmus_PLK1 -----------DA----VP----------------------------------------- plk-2_Cele_PLK1 ------------------------------------------------------------ plk-1_Cele_PLK1 ------------------------------------------------------------ F55G1.8_Cele_PLK1 ------------------------------------------------------------ CDC5_Scer_PLK1 ------------------------------------------------------------ zyg-1_Cele_SAK ------------------------------------------------------------ PLK_Ddis_PLK1 -----------LP----NK----------------------------------------- 8635_Tthe_SAK YTKLILVVLEELP----QIFNQYSDISFLSLNQINLQLLKVKMWLIDPDTFEDQSEINEQ 18358b_Tthe_PLK-Unclassified ------------------------------------------------------------ 18380_Tthe_PLK-Unclassified -----------DQ----GV----------------------------------------- 21183_Tthe_SAK ------------------------------------------------------------ 22503_Tthe_PLK-Unclassified ------------------------------------------------------------ 5034_Tthe_SAK ------------------------------------------------------------ 8829_Tthe_PLK-Unclassified ------------------------------------------------------------ SAK_Spur_SAK ------------------------------------------------------------ PLK1_Spur_PLK1 ------------------------------------------------------------ PLK2_Spur_PLK2 -----------AR----AP----------------------------------------- n1170_Tthe_PLK-Unclassified ------------------------------------------------------------ n808_Tthe_PLK-Unclassified ------------------------------------------------------------ CC1G_07437_Ccin_PLK1 -----------KAPAKG-P----------------------------------------- AqueK200_Aque_PLK1 ------------------------------------------------------------ AqueK201_Aque_SAK ------------------------------------------------------------ GK066_Glam_PLK-Unclassified ------------------------------------------------------------ PLK4_Hsap_SAK ------------------------I-G-EKIEDFKVGNLLGKGSFAGVYR---------- PLK3_Hsap_PLK2 -G-PE-LEMLAG-LPTSDP-GRLIT-DPRSGRTYLKGRLLGKGGFARCYE---------- PLK2_Hsap_PLK2 -AAPH-HHHHH-SHSGPEI-SRIIV-DPTTGKRYCRGKVLGKGGFAKCYE---------- PLK1_Hsap_PLK1 -GAP-----AA-APPAKEI-PEVLV-DPRSRRRYVRGRFLGKGGFAKCFE---------- polo_Dmel_PLK1 ---------------STDI-PDRLV-DINQRKTYKRMRFFGKGGFAKCYE---------- SAK_Dmel_SAK ------------------------F-G-ETIEDYEVQHLLGKGGFATVYK---------- PLK5_Mmus_PLK2 ------------RRSRQLV-ATFLR-DPGSGRVYRRGKLIGKGAFSRCYK---------- PLK4_Mmus_SAK ------------------------I-G-ERIEDFKVGNLLGKGSFAGVYR---------- PLK3_Mmus_PLK2 -R-SE-PEVLAGPRAPDPP-GRLIT-DPLSGRTYTKGRLLGKGGFARCYE---------- PLK2_Mmus_PLK2 -AAPH-HHHHH-SHSGPEI-SRIIV-DPTTGKRYCRGKVLGKGGFAKCYE---------- PLK1_Mmus_PLK1 -GAP-----VA-APLAKEI-PEVLV-DPRSRRQYVRGRFLGKGGFAKCFE---------- plk-2_Cele_PLK1 ---------KK-EKAPPDV-PDVIL-DGERKTRYEKGKFLGKGGFAHCYE---------- plk-1_Cele_PLK1 ---------RK-EKAPPEV-PALIA-DKDRGTYYEKGRFLGKGGFAHCYE---------- F55G1.8_Cele_PLK1 ------------KH-VPNV-PPIIY-D-DMQVPYEKGAFLGEGGFAHCFE---------- CDC5_Scer_PLK1 ----E----KL-SA-LCKT-PPSLI-K-TRGKDYHRGHFLGEGGFARCFQ---------- zyg-1_Cele_SAK ----------------------------SRLSAYSHLKEIGKGGFGVVYA---------- PLK_Ddis_PLK1 -SNEP----QE-PIVVYET-IR-SG-DSKRLKEYRQGEFLGKGGFAKCYL---------- 8635_Tthe_SAK IKRQS----Q--I-VQKKDDLKILNE-IEIIGDIQNIEQINKGGFGSIQKGKLAKILKYP 18358b_Tthe_PLK-Unclassified -----------------------------------------KGGFAKCYE---------- 18380_Tthe_PLK-Unclassified -ANYP----TE-QKIIEEKTENKVT-GEKIIKKYSRGKLLGSGGFAKCYE---------- 21183_Tthe_SAK --------------V-EEEENHLMNSISTSLHNFKITLTLGRGAGSCVFL---------- 22503_Tthe_PLK-Unclassified -QAQP----QR-N-LLHEKRKN-QDGEWKVERSYEVLSKLGKGGFAKVYL---------- 5034_Tthe_SAK --------------INEQERNSLFNSLSAQLSDYIISHPIGSGAGSLVVK---------- 8829_Tthe_PLK-Unclassified ------------LIIIEEK-ISKVN-GEMAVKKYLRGKLLGKGGFAKCYE---------- SAK_Spur_SAK ----------------------------DRIENYQVLNLLGRGGFACVYR---------- PLK1_Spur_PLK1 -------------LRVKEV-PDVVT-DPSTGKTYTKGRFLGKGGFAKCYE---------- PLK2_Spur_PLK2 -KAT-----PA-VSKLPEL-PAVIV-DPESGERYRRGRLLG-GGFARCYE---------- n1170_Tthe_PLK-Unclassified -AASD----TE-PLIIEER-VQIVN-GEQIIKRYQRGSLLGKGGFAKCFQ---------- n808_Tthe_PLK-Unclassified -AASD----TE-PLIIEER-VQIVN-GEQIIKRYQRGSLLGKGGFAKCFQ---------- CC1G_07437_Ccin_PLK1 -SSPPLPRQNS-KTRPPSP-PKVIS-DKAGRLQFNRVGFLGEGGFARVYE---------- AqueK200_Aque_PLK1 ----------A-SSLSKPL-KEFVT-NPDTKKRYEKGRFLGKGGFAKCYE---------- AqueK201_Aque_SAK --------------------------------DYEVLNRLGKGSFADVYR---------- GK066_Glam_PLK-Unclassified -----------------EL-HPQIV-DPFHNVTYRPGKLLGKGGFAYVYE---------- *. . PLK4_Hsap_SAK ------------------------------------------------------------ PLK3_Hsap_PLK2 ------------------------------------------------------------ PLK2_Hsap_PLK2 ------------------------------------------------------------ PLK1_Hsap_PLK1 ------------------------------------------------------------ polo_Dmel_PLK1 ------------------------------------------------------------ SAK_Dmel_SAK ------------------------------------------------------------ PLK5_Mmus_PLK2 ------------------------------------------------------------ PLK4_Mmus_SAK ------------------------------------------------------------ PLK3_Mmus_PLK2 ------------------------------------------------------------ PLK2_Mmus_PLK2 ------------------------------------------------------------ PLK1_Mmus_PLK1 ------------------------------------------------------------ plk-2_Cele_PLK1 ------------------------------------------------------------ plk-1_Cele_PLK1 ------------------------------------------------------------ F55G1.8_Cele_PLK1 ------------------------------------------------------------ CDC5_Scer_PLK1 ------------------------------------------------------------ zyg-1_Cele_SAK ------------------------------------------------------------ PLK_Ddis_PLK1 ------------------------------------------------------------ 8635_Tthe_SAK LYGHFSQTMSLITKLYIMWQIAQGIQFLTSKNVAHLDLKPANIVISKGYLAKIIDFGEAY 18358b_Tthe_PLK-Unclassified ------------------------------------------------------------ 18380_Tthe_PLK-Unclassified ------------------------------------------------------------ 21183_Tthe_SAK ------------------------------------------------------------ 22503_Tthe_PLK-Unclassified ------------------------------------------------------------ 5034_Tthe_SAK ------------------------------------------------------------ 8829_Tthe_PLK-Unclassified ------------------------------------------------------------ SAK_Spur_SAK ------------------------------------------------------------ PLK1_Spur_PLK1 ------------------------------------------------------------ PLK2_Spur_PLK2 ------------------------------------------------------------ n1170_Tthe_PLK-Unclassified ------------------------------------------------------------ n808_Tthe_PLK-Unclassified ------------------------------------------------------------ CC1G_07437_Ccin_PLK1 ------------------------------------------------------------ AqueK200_Aque_PLK1 ------------------------------------------------------------ AqueK201_Aque_SAK ------------------------------------------------------------ GK066_Glam_PLK-Unclassified ------------------------------------------------------------ PLK4_Hsap_SAK ------------------------------------------------------------ PLK3_Hsap_PLK2 ------------------------------------------------------------ PLK2_Hsap_PLK2 ------------------------------------------------------------ PLK1_Hsap_PLK1 ------------------------------------------------------------ polo_Dmel_PLK1 ------------------------------------------------------------ SAK_Dmel_SAK ------------------------------------------------------------ PLK5_Mmus_PLK2 ------------------------------------------------------------ PLK4_Mmus_SAK ------------------------------------------------------------ PLK3_Mmus_PLK2 ------------------------------------------------------------ PLK2_Mmus_PLK2 ------------------------------------------------------------ PLK1_Mmus_PLK1 ------------------------------------------------------------ plk-2_Cele_PLK1 ------------------------------------------------------------ plk-1_Cele_PLK1 ------------------------------------------------------------ F55G1.8_Cele_PLK1 ------------------------------------------------------------ CDC5_Scer_PLK1 ------------------------------------------------------------ zyg-1_Cele_SAK ------------------------------------------------------------ PLK_Ddis_PLK1 ------------------------------------------------------------ 8635_Tthe_SAK HPDVCNGKEFYNNQQRLIFKSYFLMKGNPNYKPGRTLPYTPYSNNNDRQASYKNLDIFSF 18358b_Tthe_PLK-Unclassified ------------------------------------------------------------ 18380_Tthe_PLK-Unclassified ------------------------------------------------------------ 21183_Tthe_SAK ------------------------------------------------------------ 22503_Tthe_PLK-Unclassified ------------------------------------------------------------ 5034_Tthe_SAK ------------------------------------------------------------ 8829_Tthe_PLK-Unclassified ------------------------------------------------------------ SAK_Spur_SAK ------------------------------------------------------------ PLK1_Spur_PLK1 ------------------------------------------------------------ PLK2_Spur_PLK2 ------------------------------------------------------------ n1170_Tthe_PLK-Unclassified ------------------------------------------------------------ n808_Tthe_PLK-Unclassified ------------------------------------------------------------ CC1G_07437_Ccin_PLK1 ------------------------------------------------------------ AqueK200_Aque_PLK1 ------------------------------------------------------------ AqueK201_Aque_SAK ------------------------------------------------------------ GK066_Glam_PLK-Unclassified ------------------------------------------------------------ PLK4_Hsap_SAK ------------------------------------------------------------ PLK3_Hsap_PLK2 ------------------------------------------------------------ PLK2_Hsap_PLK2 ------------------------------------------------------------ PLK1_Hsap_PLK1 ------------------------------------------------------------ polo_Dmel_PLK1 ------------------------------------------------------------ SAK_Dmel_SAK ------------------------------------------------------------ PLK5_Mmus_PLK2 ------------------------------------------------------------ PLK4_Mmus_SAK ------------------------------------------------------------ PLK3_Mmus_PLK2 ------------------------------------------------------------ PLK2_Mmus_PLK2 ------------------------------------------------------------ PLK1_Mmus_PLK1 ------------------------------------------------------------ plk-2_Cele_PLK1 ------------------------------------------------------------ plk-1_Cele_PLK1 ------------------------------------------------------------ F55G1.8_Cele_PLK1 ------------------------------------------------------------ CDC5_Scer_PLK1 ------------------------------------------------------------ zyg-1_Cele_SAK ------------------------------------------------------------ PLK_Ddis_PLK1 ------------------------------------------------------------ 8635_Tthe_SAK GMVLSEIVFDTYPVDFKRGALHKLEEKFSRGDIRGRLVKNYQRHFGPKHIINLLHCLIFR 18358b_Tthe_PLK-Unclassified ------------------------------------------------------------ 18380_Tthe_PLK-Unclassified ------------------------------------------------------------ 21183_Tthe_SAK ------------------------------------------------------------ 22503_Tthe_PLK-Unclassified ------------------------------------------------------------ 5034_Tthe_SAK ------------------------------------------------------------ 8829_Tthe_PLK-Unclassified ------------------------------------------------------------ SAK_Spur_SAK ------------------------------------------------------------ PLK1_Spur_PLK1 ------------------------------------------------------------ PLK2_Spur_PLK2 ------------------------------------------------------------ n1170_Tthe_PLK-Unclassified ------------------------------------------------------------ n808_Tthe_PLK-Unclassified ------------------------------------------------------------ CC1G_07437_Ccin_PLK1 ------------------------------------------------------------ AqueK200_Aque_PLK1 ------------------------------------------------------------ AqueK201_Aque_SAK ------------------------------------------------------------ GK066_Glam_PLK-Unclassified ------------------------------------------------------------ PLK4_Hsap_SAK ------------------------------------------------------------ PLK3_Hsap_PLK2 ------------------------------------------------------------ PLK2_Hsap_PLK2 ------------------------------------------------------------ PLK1_Hsap_PLK1 ------------------------------------------------------------ polo_Dmel_PLK1 ------------------------------------------------------------ SAK_Dmel_SAK ------------------------------------------------------------ PLK5_Mmus_PLK2 ------------------------------------------------------------ PLK4_Mmus_SAK ------------------------------------------------------------ PLK3_Mmus_PLK2 ------------------------------------------------------------ PLK2_Mmus_PLK2 ------------------------------------------------------------ PLK1_Mmus_PLK1 ------------------------------------------------------------ plk-2_Cele_PLK1 ------------------------------------------------------------ plk-1_Cele_PLK1 ------------------------------------------------------------ F55G1.8_Cele_PLK1 ------------------------------------------------------------ CDC5_Scer_PLK1 ------------------------------------------------------------ zyg-1_Cele_SAK ------------------------------------------------------------ PLK_Ddis_PLK1 ------------------------------------------------------------ 8635_Tthe_SAK CIDEKENRPTIDWIILISIYFKEVNKFYQQQICKHKKTFKATKRVLTKKESTEIYFERQI 18358b_Tthe_PLK-Unclassified ------------------------------------------------------------ 18380_Tthe_PLK-Unclassified ------------------------------------------------------------ 21183_Tthe_SAK ------------------------------------------------------------ 22503_Tthe_PLK-Unclassified ------------------------------------------------------------ 5034_Tthe_SAK ------------------------------------------------------------ 8829_Tthe_PLK-Unclassified ------------------------------------------------------------ SAK_Spur_SAK ------------------------------------------------------------ PLK1_Spur_PLK1 ------------------------------------------------------------ PLK2_Spur_PLK2 ------------------------------------------------------------ n1170_Tthe_PLK-Unclassified ------------------------------------------------------------ n808_Tthe_PLK-Unclassified ------------------------------------------------------------ CC1G_07437_Ccin_PLK1 ------------------------------------------------------------ AqueK200_Aque_PLK1 ------------------------------------------------------------ AqueK201_Aque_SAK ------------------------------------------------------------ GK066_Glam_PLK-Unclassified ------------------------------------------------------------ PLK4_Hsap_SAK ---------------------------------------AES------------------ PLK3_Hsap_PLK2 ---------------------------------------ATD------------------ PLK2_Hsap_PLK2 ---------------------------------------MTD------------------ PLK1_Hsap_PLK1 ---------------------------------------ISD------------------ polo_Dmel_PLK1 ---------------------------------------IID------------------ SAK_Dmel_SAK ---------------------------------------ARC------------------ PLK5_Mmus_PLK2 ---------------------------------------LTD------------------ PLK4_Mmus_SAK ---------------------------------------AES------------------ PLK3_Mmus_PLK2 ---------------------------------------ATD------------------ PLK2_Mmus_PLK2 ---------------------------------------MTD------------------ PLK1_Mmus_PLK1 ---------------------------------------ISD------------------ plk-2_Cele_PLK1 ---------------------------------------LRN------------------ plk-1_Cele_PLK1 ---------------------------------------LTN------------------ F55G1.8_Cele_PLK1 ---------------------------------------FRK------------------ CDC5_Scer_PLK1 ---------------------------------------IKD------------------ zyg-1_Cele_SAK ---------------------------------------AQR------------------ PLK_Ddis_PLK1 ---------------------------------------MTE------------------ 8635_Tthe_SAK KQFLYPLMIYTQVSDELSFKDIEASLDYDIKGANGFVCKIEDFKSKECYNSNEAKKYYVY 18358b_Tthe_PLK-Unclassified ---------------------------------------FTN------------------ 18380_Tthe_PLK-Unclassified ---------------------------------------VIA------------------ 21183_Tthe_SAK ---------------------------------------IEE------------------ 22503_Tthe_PLK-Unclassified ---------------------------------------AKD------------------ 5034_Tthe_SAK ---------------------------------------VKS------------------ 8829_Tthe_PLK-Unclassified ---------------------------------------VTN------------------ SAK_Spur_SAK ---------------------------------------AKT------------------ PLK1_Spur_PLK1 ---------------------------------------LTD------------------ PLK2_Spur_PLK2 ---------------------------------------LTH------------------ n1170_Tthe_PLK-Unclassified ---------------------------------------VTN------------------ n808_Tthe_PLK-Unclassified ---------------------------------------VTN------------------ CC1G_07437_Ccin_PLK1 ---------------------------------------VQD------------------ AqueK200_Aque_PLK1 ---------------------------------------LIC------------------ AqueK201_Aque_SAK ---------------------------------------AKC------------------ GK066_Glam_PLK-Unclassified ---------------------------------------FHD------------------ PLK4_Hsap_SAK --IHT--GLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKH-PSILELYNYFEDSNYVY PLK3_Hsap_PLK2 --TET--GSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQH-RHIVRFSHHFEDADNIY PLK2_Hsap_PLK2 --LTN--NKVYAAKIIPHSRVAKPHQREKIDKEIELHRILHH-KHVVQFYHYFEDKENIY PLK1_Hsap_PLK1 --ADT--KEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAH-QHVVGFHGFFEDNDFVF polo_Dmel_PLK1 --VET--DDVFAGKIVSKKLMIKHNQKEKTAQEITIHRSLNH-PNIVKFHNYFEDSQNIY SAK_Dmel_SAK --LHT--HQDVAIKMIDKKLIQGTGLTNRVRQEVEIHSRLKH-PSVLQLYTFFQDANYVY PLK5_Mmus_PLK2 --MST--SAVFALKVVPRGGAGRLRLRGKVEREIALHSRLRH-RNIVAFHAHFADRDHVY PLK4_Mmus_SAK --IHT--GLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKH-PSVLELYNYFEDNNYVY PLK3_Mmus_PLK2 --TES--GIAYAVKVIPQSRVAKPHQREKILNEIELHRDLQH-RHIVRFSHHFEDADNIY PLK2_Mmus_PLK2 --LTN--NKVYAAKIIPHSRVAKPHQREKIDKEIELHRLLHH-KHVVQFYHYFEDKENIY PLK1_Mmus_PLK1 --ADT--KEVFAGKIVPKSLLLKPHQKEKMSMEISIHRSLAH-QHVVGFHDFFEDSDFVF plk-2_Cele_PLK1 --KST--GELFAGKVVPKALLIKQYQRDKMAQEVQIHRNLQH-RNVVKLYHFFEDKSNVY plk-1_Cele_PLK1 --RAT--REVVAGKVVPKSMLVKQYQRDKMTQEVQIHRELGH-INIVKLFNFFEDNLNVY F55G1.8_Cele_PLK1 --LDC--NDRLAVKVVPKVILLKSTAREKLTREVEIHRQLSH-RNIVQFHHFFEDSQNVY CDC5_Scer_PLK1 ---DS--GEIFAAKTVAKASIKSEKTRKKLLSEIQIHKSMSH-PNIVQFIDCFEDDSNVY zyg-1_Cele_SAK ---EN--GEKVAIKRIDKK-----VPKNRVWTEIQTMKELKKSKYVVEFYEDFVEDGYTY PLK_Ddis_PLK1 --VET--NRIYAAKIIPKSTLQKTRARSKLKSEIKIHSSLSH-ENIVKFEHCFENEENVY 8635_Tthe_SAK LLLTY--TKQKAMKVVDKKRKDIQNVMKRLDQEIKIQKELDH-PNIIKLFKHFEDDQNHY 18358b_Tthe_PLK-Unclassified --LER--KQVLAAKVIPKSSLTKSRARQKLMSEIRIHKSLNH-RNIVKFQHFFEDQENVY 18380_Tthe_PLK-Unclassified --LDTDPKAIFAAKIIPKSTLTKSRQRVKLISEIKIHKSLHH-KNIVQFEHVFEDHDNVY 21183_Tthe_SAK --YKS--G------------------------SLYLHSQLDH-PNIVKILKRFEDNEYVY 22503_Tthe_PLK-Unclassified --ISS--NEQYAIKVVDKSSLEKDSFKEKLNQEIKIQKSLNH-ENVVKYYTSFEDSQNVY 5034_Tthe_SAK --IKT--KKEYAIKVVDKQSQYYKSAYKRLKNEIEIHLDLKH-KNIVKMIKSFEDSENLY 8829_Tthe_PLK-Unclassified --LET--KKIIAAKIIPKQTLTKNRARQKLISEIKIHKSLNH-QHVVAFEHVFEDHENVY SAK_Spur_SAK --IST--GQEVAIKMIDKKLMQSSGMATRVKNEVEIHCQLKH-PSILELYSYFEDNNYVY PLK1_Spur_PLK1 --DAT--KQIFAGKVVSKALLVKPHQKDKMTMEIHIHKSLHH-RHVVGFHSFFEDKENVY PLK2_Spur_PLK2 --LDT--HYVYAGKIVPKERISKPSQREKMEREIAVHAQLRH-PHIVGFHKHFQDAENIY n1170_Tthe_PLK-Unclassified --LEN--KKVMAAKIIPKSTLVKNRARQKLISEIKIHKSLHH-NNIVKFEHVFEDHDNVY n808_Tthe_PLK-Unclassified --LEN--KKVMAAKIIPKSTLVKNRARQKLISEIKIHKSLHH-NNIVKFEHVFEDHDNVY CC1G_07437_Ccin_PLK1 --PR---GSRLACKVVTKSALKTKKAKTKLYAEIKIHRSLDH-PNIVTFIDCFEDEDNVY AqueK200_Aque_PLK1 --EET--GTVYAGKIVAKELLVKPHQKEKMTQEIEIHRSLSH-KHVVGFHGFFDDSNNVY AqueK201_Aque_SAK --KRT--KKEVAIKMIDKKLMVKKGMTERVKNEVKIHSHLKH-PSILELYDFFEDSNYVY GK066_Glam_PLK-Unclassified --VNS--DSSYACKITPRSALQKKKYYDKFVTEVTIHRGLVH-PNICRVLNVFKDQMNYY .: : : : * : : PLK4_Hsap_SAK LVLEMCHNG----EMNRYL-------KNRVKPFSENEARHFMHQIITGMLYLHSHGILHR PLK3_Hsap_PLK2 IFLELCSRK----SLAHIW-------KAR-HTLLEPEVRYYLRQILSGLKYLHQRGILHR PLK2_Hsap_PLK2 ILLEYCSRR----SMAHIL-------KAR-KVLTEPEVRYYLRQIVSGLKYLHEQEILHR PLK1_Hsap_PLK1 VVLELCRRR----SLLELH-------KRR-KALTEPEARYYLRQIVLGCQYLHRNRVIHR polo_Dmel_PLK1 IVLELCKKR----SMMELH-------KRR-KSITEFECRYYIYQIIQGVKYLHDNRIIHR SAK_Dmel_SAK LVLELAHNG----ELHRYM-------NHIARPFTETEAASILKQVVAGLLYLHSHNIMHR PLK5_Mmus_PLK2 MVLEYCSRQVPLQSLAHVL-------KVR-RTLTEPEVRYYLRGLVSGLRYLHQQRIVHR PLK4_Mmus_SAK LVLEMCHNG----EMNRYL-------KNRMKPFSEREARHFMHQIITGMLYLHSHGILHR PLK3_Mmus_PLK2 IFLELCSRK----SLAHIW-------KAR-HTLLEPEVRYYLRQILSGLKYLHQRGILHR PLK2_Mmus_PLK2 ILLEYCSRR----SMAHIL-------KAR-KVLTEPEVRYYLRQIVSGLKYLHEQEILHR PLK1_Mmus_PLK1 VVLELCRRR----SLLELH-------KRR-KALTEPEARYYLRQIVLGCQYLHRNQVIHR plk-2_Cele_PLK1 ITLELCPRR----SLMELH-------KRR-KAVTEPEARYFTYQIVEGVLYLHNLKIVHR plk-1_Cele_PLK1 ITLELCARR----SLMELH-------KRR-KAVTEPEARYFTHQIVDGVLYLHDLNIIHR F55G1.8_Cele_PLK1 FTLELCSKN----SLMELN-------KQR-GPLTEHEARFYTIQVAEGVKHLHNLQIIHR CDC5_Scer_PLK1 ILLEICPNG----SLMELL-------KRR-KVLTEPEVRFFTTQICGAIKYMHSRRVIHR zyg-1_Cele_SAK IVMELCEGG----SLQAYV-------REH-GALDDATAVHVLRQLISAVSFMHRVNVIHR PLK_Ddis_PLK1 ILLELCNQK----TVMDIH-------KKR-KYLMEYETKYYVYQVIMAVQYLHNNNIIHR 8635_Tthe_SAK LIMELAQNG----EIKDYL-------NIN-K----------PYQLACGIKYLHDKDIVHR 18358b_Tthe_PLK-Unclassified ILLEMCTNQ----TMNELI-------RRR-KRLTELEVQCYLLQILYSIKYLHDNRVIHR 18380_Tthe_PLK-Unclassified ILLELCPYQ----TLNELI-------KRR-KRITEYETQIYVMQIVNALKYLHQNKIIHR 21183_Tthe_SAK MMLEYCPGG----SLFDYIVYINFQLFEK-TRLNEDEARDISYQIVQGLEYLHKNKIIHR 22503_Tthe_PLK-Unclassified IVLEYCSNQ----EL---L-------DRR-KRLTEIEVKSHLFQIIQSLKYIHSKGVIHR 5034_Tthe_SAK LVMEYCEGG----DLFHYL-------KHH-KKLSETEAKRITYKLAEGLKYLHDKSIIHR 8829_Tthe_PLK-Unclassified ILLELCTNH----TLNELI-------KRR-KRLTELEVQCYVVQIVNALKYLHSHKVIHR SAK_Spur_SAK LVLELAQNG----ELLRYL-------KKKARVFGEEEARQFLEEIVIGLLYLHSHGILHR PLK1_Spur_PLK1 VLLELCRRR----SLMELH-------KRR-KAITEPETRYFMRQCILACQYLSKTKVIHR PLK2_Spur_PLK2 ILLELCRHK----SLLHML-------KLR-KHLTEPEVRYFMLQIIEGVRYLHSHCVIHR n1170_Tthe_PLK-Unclassified ILLELCPHQ----TLNELI-------KRR-KRITELETLCYTVQIVQALKYLHQNRVIHR n808_Tthe_PLK-Unclassified ILLELCPHQ----TLNELI-------KRR-KRITELETLCYTVQIVQALKYLHQNRVIHR CC1G_07437_Ccin_PLK1 ITLELCPSG----SLMDML-------RRR-RRFTEPETRFFMVQLIGACHYMHTHQVIHR AqueK200_Aque_PLK1 ILLELCKRR----SLMELH-------KRR-KALTEPEVRYLFRQTVLAVDYLHDVKVIHR AqueK201_Aque_SAK LILEFCQNG----ELNRYL-------KHRQKSLSE-DERIILNQVVKGLIYLHSFNIVHR GK066_Glam_PLK-Unclassified IILEKCNGG----TLTDLI-------RRR-KHLTETEARFFSKRILNALWYLHDLYIIHR . :* . : . .: ::** PLK4_Hsap_SAK DLTLSNLLLTR----NMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEI--------- PLK3_Hsap_PLK2 DLKLGNFFITE----NMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEV--------- PLK2_Hsap_PLK2 DLKLGNFFINE----AMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEV--------- PLK1_Hsap_PLK1 DLKLGNLFLNE----DLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEV--------- polo_Dmel_PLK1 DLKLGNLFLND----LLHVKIGDFGLATRIEYEGERKKTLCGTPNYIAPEI--------- SAK_Dmel_SAK DISLSNLLLSR----EMHVKIADFGLATQLKRPDERHMTMCGTPNYISPEV--------- PLK5_Mmus_PLK2 DLKPSNFFLNK----NMEVKIGDLGLAARVGPAGRCHRVLCGTPNFQAPEV--------- PLK4_Mmus_SAK DLTLSNILLTR----NMNIKIADFGLATQLNMPHEKHYTLCGTPNYISPEI--------- PLK3_Mmus_PLK2 DLKLGNFFITD----NMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEV--------- PLK2_Mmus_PLK2 DLKLGNFFINE----AMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEV--------- PLK1_Mmus_PLK1 DLKLGNLFLNE----DLEVKIGDFGLATKVEYEGERKKTLCGTPNYIAPEV--------- plk-2_Cele_PLK1 DLKLGNLFLND----ELQVKIGDFGLATTCDN-DERKKTLCGTPNYIAPEV--------- plk-1_Cele_PLK1 DMKLGNLFLND----DLVVKIGDFGLATTVNG-DERKKTLCGTPNYIAPEV--------- F55G1.8_Cele_PLK1 DLKLGNLFLNE----HLQVKIGDFGLATFCEK-NEKKMTRGGTPNYIAPEV--------- CDC5_Scer_PLK1 DLKLGNIFFDS----NYNLKIGDFGLAAVLANESERKYTICGTPNYIAPEV--------- zyg-1_Cele_SAK DLSAGNVFIKDSKKKKMTVKLGDFGLATTLGR-GETTCTIVGTPGFIAPQV--------- PLK_Ddis_PLK1 DLKLGNLFI-D----NMRIKLGDFGLSTKVEH-GERKKTICGTPNYIAPEI--------- 8635_Tthe_SAK DLKLNNVLLS-----NGKIKIADFGLATKVNDENPECNTMCGTANYLSPEI--------- 18358b_Tthe_PLK-Unclassified DLKLGNLFLSD----KMEIKLGDFGLATKLEYDGERKRTICGTPNYIAPEI--------- 18380_Tthe_PLK-Unclassified DLKLGNLFLGD----NMTLKIGDFGLATKIEYEGEKKKTVCGTPNYIAPEI--------- 21183_Tthe_SAK DLKPGNILLTG----NNSVKICDFGLAVRVTNYESERDTFCGTPNYIAPEK--------- 22503_Tthe_PLK-Unclassified DLKIANIFLND----KMVVKLADFGLSAMMKN-AQKRKTVCGTPNYIAPEV--------- 5034_Tthe_SAK DLKLGNVLLSS----DHQVKICDFGLAVRLNGNEQEKNTICGTPNYISPEI--------- 8829_Tthe_PLK-Unclassified DLKLGNLFLNE----KMEIKLGDFGLATKLEFDGEKKHTICGTPNYIAPEI--------- SAK_Spur_SAK DLTLANILLTR----DMHCKIADFGLAAQLKLPEEQHYTMCGTPNYISPEI--------- PLK1_Spur_PLK1 DLKLGNLFIDD----NMELKVGDFGLATKVDFSGERKKTLCGTPNYIAPEV--------- PLK2_Spur_PLK2 DLKLGNMFLTD----TMGVKIGDFGLAAKLEFEGDRKRTMCGTPNYIAPEV--------- n1170_Tthe_PLK-Unclassified DLKLGNLFVGE----KMEIKLGDFGLATKLEFDGEKKRTICGTPNYIAPEI--------- n808_Tthe_PLK-Unclassified DLKLGNLFVGE----KMEIKLGDFGLATKLEFDGEKKRTICGTPNYIAPEI--------- CC1G_07437_Ccin_PLK1 DLKLGNLFLDA----NMNVKVGDFGLAALIENPGERKKTICGTPNYIAPEV--------- AqueK200_Aque_PLK1 DLKLGNLFLND----DIEIKLGDFGLATRLEEDGERKKTLCGTPNYIAPEV--------- AqueK201_Aque_SAK DLSLSNILLTS----SMDIKIADFGLSVTLDLPGDKHHTLCGTPNYIAPYVICCYEGCFL GK066_Glam_PLK-Unclassified DIKTSNIFLME----DFDVKVGDFGLAVKCETPEELHWTMCGTPNFLPSEV--------- *:. *.:. *: *:**:. . **..: .. PLK4_Hsap_SAK --------AT---------------------------------RSAHGLESDVWSLGCMF PLK3_Hsap_PLK2 --------LL---------------------------------RQGHGPEADVWSLGCVM PLK2_Hsap_PLK2 --------LN---------------------------------KQGHGCESDIWALGCVM PLK1_Hsap_PLK1 --------LS---------------------------------KKGHSFEVDVWSIGCIM polo_Dmel_PLK1 --------LT---------------------------------KKGHSFEVDIWSIGCVM SAK_Dmel_SAK --------VS---------------------------------RTSHGLPADVWSVGCML PLK5_Mmus_PLK2 --------VS---------------------------------RNGHSCKSDIWALGCIM PLK4_Mmus_SAK --------AT---------------------------------RSAHGLESDIWSLGCMF PLK3_Mmus_PLK2 --------LL---------------------------------RQGHGPEADVWSLGCVM PLK2_Mmus_PLK2 --------LN---------------------------------KQGHGCESDIWALGCVM PLK1_Mmus_PLK1 --------LS---------------------------------KKGHSFEVDVWSIGCIM plk-2_Cele_PLK1 --------LN---------------------------------KIGHSFEVDLWAIGCIL plk-1_Cele_PLK1 --------LN---------------------------------KAGHSFEVDIWAVGCIL F55G1.8_Cele_PLK1 --------LN---------------------------------ETGHAFEVDIWAIGCIL CDC5_Scer_PLK1 --------LMG-------------------------------KHSGHSFEVDIWSLGVML zyg-1_Cele_SAK --------YD---------------------------------Q-EYTQSADVYSLGAVL PLK_Ddis_PLK1 --------LD--------------------------------NSNGHSYEVDVWSIGIIL 8635_Tthe_SAK --------LN---------------------------------SKGYGKKTDIWSFGCIL 18358b_Tthe_PLK-Unclassified --------LEA-------------------------------KETGHSYEVDVWSFGVIA 18380_Tthe_PLK-Unclassified --------LE--------------------------------GKDGHSYEVDMWSLGVII 21183_Tthe_SAK ----------------------------------------------YGIQSDCWSFGCIL 22503_Tthe_PLK-Unclassified --------LK---------------------------------NQGHDYLVDNWAIGVIV 5034_Tthe_SAK --------LN---------------------------------KQPYGMKIDCWSFGCIL 8829_Tthe_PLK-Unclassified --------LD--------------------------------GKTGHSYQVDIWSLGVII SAK_Spur_SAK --------AT---------------------------------RGPHGLQSDVWSLGCML PLK1_Spur_PLK1 --------LS---------------------------------KKGHSYEVDLWSLGCIM PLK2_Spur_PLK2 --------LG---------------------------------KIGHSFEADVWALGCIM n1170_Tthe_PLK-Unclassified --------LD--------------------------------GRVGHSYEVDIWSLGVIL n808_Tthe_PLK-Unclassified --------LD--------------------------------GRVGHSYEVDIWSLGVIL CC1G_07437_Ccin_PLK1 --------LFD-------------------------------TANGHSFEVDIWSIGVIL AqueK200_Aque_PLK1 --------LT---------------------------------KKGHSYEVDIWSLGCIL AqueK201_Aque_SAK IFIFCREVAK---------------------------------REAHGLESDIWSLGCMV GK066_Glam_PLK-Unclassified --------IYSHIMKRKASGRGPDPNLDEDCVNLCHQLLPAYSGQGHSFSADMWSFGCLV : * ::.* : PLK4_Hsap_SAK YTLLIGRPPFDTDTVKNTLNKVV-LAD--YEMPS--FLSIEAKDLIHQLLRRNPADRLSL PLK3_Hsap_PLK2 YTLLCGSPPFETADLKETYRCIK-QVH--YTLPAS--LSLPARQLLAAILRASPRDRPSI PLK2_Hsap_PLK2 YTMLLGRPPFETTNLKETYRCIR-EAR--YTMPSS--LLAPAKHLIASMLSKNPEDRPSL PLK1_Hsap_PLK1 YTLLVGKPPFETSCLKETYLRIK-KNE--YSIPKH--INPVAASLIQKMLQTDPTARPTI polo_Dmel_PLK1 YTLLVGQPPFETKTLKDTYSKIK-KCE--YRVPSY--LRKPAADMVIAMLQPNPESRPAI SAK_Dmel_SAK YTLLVGRPPFETDAVQSTLNKVV-MSE--YIMPA--HLSYEAQDLINKLLKKLPHERITL PLK5_Mmus_PLK2 YTVLTGTPPFAAAPLSEMYQNIR-DGH--YLEPTH--LSPSARSLIARLLAPDPAERPSL PLK4_Mmus_SAK YTLLIGRPPFDTDTVKNTLNKVV-LAD--YEMPA--FLSREAQDLIHQLLRRNPADRLSL PLK3_Mmus_PLK2 YTLLCGSPPFETADLKETYRCIK-QVH--YTLPAS--LSLPARQLLAAILRASPRDRPSI PLK2_Mmus_PLK2 YTMLLGRPPFETTNLKETYRCIR-EAR--YTMPSS--LLAPAKHLIASMLSKNPEDRPSL PLK1_Mmus_PLK1 YTLLVGKPPFETSCLKETYLRIK-KNE--YSIPKH--INPVAASLIQKMLQTDPTARPTI plk-2_Cele_PLK1 YILLFGHPPFESKSLEETYSRIK-NNN--YVIPTS--ASAAASQLIRVLLDPVPSRRPNA plk-1_Cele_PLK1 YILLFGQPPFESKSLEETYSRIR-HNN--YTIPSI--ATQPAASLIRKMLDPEPTRRPTA F55G1.8_Cele_PLK1 YVLLFGSPPFESRRVQETYVRIK-NND--YVVPE--NASPTANRLIRSLLDPVPDRRPTA CDC5_Scer_PLK1 YALLIGKPPFQARDVNTIYERIK-CRD--FSFPRDKPISDEGKILIRDILSLDPIERPSL zyg-1_Cele_SAK YTMLTARNPPPK------------------GLPPTCGMSPNAARLVEQMMDTDAKKRIPL PLK_Ddis_PLK1 YTLLIGKPPFETSDVKHTYQRIK-QNQ--YSFPDEPIISHYGKSLIISILNPVPEQRPNL 8635_Tthe_SAK YALCSGNLPFFSGNPSQTIQNIK-EGK--WQLPQN--ISDNVKDLLSNTLNWDQNSRFSI 18358b_Tthe_PLK-Unclassified YTLLIGKPPFETNDVKSTYKKIR-TNE--YSFPEQIQISSAAKNMIKKILTTDPSKRPTI 18380_Tthe_PLK-Unclassified YTLLIGKPPFETKDVRTTYKRIK-MNN--YCFPEQIQISDNAKSIITSILNLNPQKRLTL 21183_Tthe_SAK YTIATGRPPFETVSIQQTLKMLQKKNK--VEYPSH--LSKSLVDLIDHILDWNQDTRYNI 22503_Tthe_PLK-Unclassified YTFLIGKPPFEEKEVENTLRNIK-ANR--YSFPENCTISKEAKDFIQKILVPNPDQRLTM 5034_Tthe_SAK YALIVGHPPFQGQDIVQTLKKVT-SQEQFFELPNN--ISDNLKDLLVNIINWNQDSRFTI 8829_Tthe_PLK-Unclassified YTLLIGKPPFETPDVKTTYKKIR-NIS--YGFPENVPISDQARGLITRILNIDPQRRPTL SAK_Spur_SAK YTFLTGTPPFDTEAVKTTLNKVM-LAE--YIIPT--HISMEAKDLINKMLRKDPTERIGL PLK1_Spur_PLK1 YTLLVGKPPFETQSLKDTYQRIK-RNE--YRVPSH--VSTPARNLIVKLLKNDPTQRPHI PLK2_Spur_PLK2 YTMLVGRPPFETSSLKETYARIK-HNK--YHFPET--LSPVAKEIISDLLSSDPEERPPL n1170_Tthe_PLK-Unclassified YTLLIGKPPFETHDVKTTYRKIK-SNQ--YSFPDHAPIPDSAKALIQLILQQDPAKRPTL n808_Tthe_PLK-Unclassified YTLLIGKNNCIQL----SFRRSR-K-Q--YSR---------------------------- CC1G_07437_Ccin_PLK1 YTLVIGRPPFQTKEVKEIYKRIR-DNE--YEFPAERAISTAVKVLIQQILTPDPSQRPTL AqueK200_Aque_PLK1 YTLLVGKPPFETKTLKDTYQRIK-RNE--YHIPHY--VGPEARTLISNLLRPNPANRPTA AqueK201_Aque_SAK YTMLVGTPPFDTDDVQSTLDNVV-NGD--FDIPQ--YITTNCTSLNL--HVYHPSKRLTL GK066_Glam_PLK-Unclassified FSMIYGRPPFEAADIKTTYKRIV-RCD--FSFPGSISVSEDLKNFIKGLLTPDPRKRFTV : . . PLK4_Hsap_SAK SSVLDHPFMSRN--SSTK-----SKDLGT--V---------------------------- PLK3_Hsap_PLK2 DQILRHDFFTKG--YTPD-----RLPISS--C---------------------------- PLK2_Hsap_PLK2 DDIIRHDFFLQG--FTPD-----RLSSSC--C---------------------------- PLK1_Hsap_PLK1 NELLNDEFFTSG--YIPA-----RLPITC--L---------------------------- polo_Dmel_PLK1 GQLLNFEFLKGS--KVPM-----FLPSSC--L---------------------------- SAK_Dmel_SAK EAVLCHPFMLKC--SNGGHSAPGALNVFS--Q---------------------------- PLK5_Mmus_PLK2 DHLLQDDFFSQG--FTPE-----RLPPHS--C---------------------------- PLK4_Mmus_SAK SSVLDHPFMSRN--PSPK-----SKDVGT--V---------------------------- PLK3_Mmus_PLK2 EQILRHDFFTKG--YTPD-----RLPVSS--C---------------------------- PLK2_Mmus_PLK2 DDIIRHDFFLQG--FTPD-----RLSSSC--C---------------------------- PLK1_Mmus_PLK1 HELLNDEFFTSG--YIPA-----RLPITC--L---------------------------- plk-2_Cele_PLK1 RAVCRDHFFKSG--FMPA-----RLPVSC--L---------------------------- plk-1_Cele_PLK1 KQVQRDGFFKSG--FMPT-----RLPVSC--L---------------------------- F55G1.8_Cele_PLK1 EAVLLDQFFKTT--IEPT-----YPPVHQ--Q---------------------------- CDC5_Scer_PLK1 TEIMDYVWFRGT---FPP-----SIPSTV--M---------------------------- zyg-1_Cele_SAK TQIVLSEFMYEN--TNEN-----AVIFSR------------------------------- PLK_Ddis_PLK1 TQILEHDFFTYS--PIPK-----YLPVSS--L---------------------------- 8635_Tthe_SAK EQVLSHKFYEKKH--KQS-----IIIFNQ--GADAISNQ--------------------- 18358b_Tthe_PLK-Unclassified NELFNDDFFKTG-GSIPK-----LLPVST--L---------------------------- 18380_Tthe_PLK-Unclassified DELLEHPFMQGT-ALNPE-----NLPISS--L---------------------------- 21183_Tthe_SAK SQIKSHPFYNKSK--QNT-----HENEYK--L---------------------------- 22503_Tthe_PLK-Unclassified DQMLQHPFMKSEEYYIPK-----TFPIST--L---------------------------- 5034_Tthe_SAK DQILMHPFYEEMR--QKS-----VKQRQE--EEESLSFFNSIRSVKGEDQRINVHQNGVK 8829_Tthe_PLK-Unclassified DEIMSSSFLNTG-GTIPK-----VLPLAT--L---------------------------- SAK_Spur_SAK STVLDHPFMDKT--RFNGTK---NRPLSKRPV---------------------------- PLK1_Spur_PLK1 DILLQDEFFTTG--YLPP-----QLPTTC--L---------------------------- PLK2_Spur_PLK2 EVVIDHEFFTQG--FVPE-----TLSPTA--C---------------------------- n1170_Tthe_PLK-Unclassified DEILAHPFINNG-GTIPR-----LLPVST--L---------------------------- n808_Tthe_PLK-Unclassified ---LAWPYFNK------------------------------------------------- CC1G_07437_Ccin_PLK1 HEIIEDTFFTHG--TVPA-----FIPTSA--H---------------------------- AqueK200_Aque_PLK1 AEILKDPFFTCG--HMPV-----RLPVSC--L---------------------------- AqueK201_Aque_SAK QQVLYHSFTKGV--QQE-----NVLQKRT--L---------------------------- GK066_Glam_PLK-Unclassified KECLDHSWLNPSKYFIPE-----SLPPRI--I---------------------------- : PLK4_Hsap_SAK -------------------EDS-----------IDSGHATISTAITASSSTSIS------ PLK3_Hsap_PLK2 -------------------VTV-----------PDLTPP------NPA--RS-------- PLK2_Hsap_PLK2 -------------------HTV-----------PDFHLS------SPA--KN-------- PLK1_Hsap_PLK1 -------------------TIP-----------PRFSIA------PSS--LD-------- polo_Dmel_PLK1 -------------------TMA-----------PRIGSN------DTI--ED-------- SAK_Dmel_SAK -------------------S-------------MESGDSGIITFASSDSRNSQQ------ PLK5_Mmus_PLK2 -------------------HSP-----------PVFAFP------PPL--GR-------- PLK4_Mmus_SAK -------------------EDS-----------MDSGHATLSTTITASSGTSLS------ PLK3_Mmus_PLK2 -------------------VTV-----------PDLTPP------NPA--RS-------- PLK2_Mmus_PLK2 -------------------HTV-----------PDFHLS------SPA--KN-------- PLK1_Mmus_PLK1 -------------------TIP-----------PRFSIA------PSS--LD-------- plk-2_Cele_PLK1 -------------------TMV-----------PHLNDD------EY----A-------- plk-1_Cele_PLK1 -------------------TMV-----------PKFGGH------ETS--MM-------- F55G1.8_Cele_PLK1 -------------------L-------------------------HKE--QD-------- CDC5_Scer_PLK1 -------------------SEA-----------PNFEDI------PEE--QS-------- zyg-1_Cele_SAK -------------------E-------------------------HSR--DGRR------ PLK_Ddis_PLK1 -------------------TTA-----------PSQSTI------NQN--MG-------- 8635_Tthe_SAK ---------------QNKLSTP--NKVLLDWTSPRFNAP---IHLQQK--SQ-SSQ---- 18358b_Tthe_PLK-Unclassified -------------------ACP-----------PSASYT------RQF--LP-------- 18380_Tthe_PLK-Unclassified -------------------VVP-----------FQKPKK------EAL--KE-------- 21183_Tthe_SAK -------------------QNP--MTF----APPQPFQM------EQS--VN-------- 22503_Tthe_PLK-Unclassified -------------------ALP-----------PTANYL------RKL--RK-------- 5034_Tthe_SAK KIDIKYQDNFFNQLEHKEGSMP--KKS----NSP--TNI------HER--KN---QMIYK 8829_Tthe_PLK-Unclassified -------------------ACP-----------PSASYT------KQF--LP-------- SAK_Spur_SAK -------------------ESS-----------LDSGLATMATISS--SHTSNR------ PLK1_Spur_PLK1 -------------------TMA-----------PRFQVP------VSS------------ PLK2_Spur_PLK2 -------------------VTA-----------PDFPIT------KVL--IS-------- n1170_Tthe_PLK-Unclassified -------------------TTA-----------PNTSYI------KQY--AP-------- n808_Tthe_PLK-Unclassified ------------------------------------------------------------ CC1G_07437_Ccin_PLK1 -------------------DAA-----------PDFRHI------SRS--AS-------- AqueK200_Aque_PLK1 -------------------TTT-----------PHFKKA------AES--A--------- AqueK201_Aque_SAK -------------------SL------------------------TTP------------ GK066_Glam_PLK-Unclassified -------------------SEPYEV--------PPLCSA------SPT--RN-------- PLK4_Hsap_SAK ---------------------------------GS---L------FDKR----------- PLK3_Hsap_PLK2 ---------------------------------L--FA---------------------- PLK2_Hsap_PLK2 ---------------------------------F--FK---------------------- PLK1_Hsap_PLK1 ---------------------------------PS-NR---------------------- polo_Dmel_PLK1 ---------------------------------SM-HR---------------------- SAK_Dmel_SAK ---------------------------------I--------------R----------- PLK5_Mmus_PLK2 ---------------------------------L--FR---------------------- PLK4_Mmus_SAK ---------------------------------GS---L------LD-R----------- PLK3_Mmus_PLK2 ---------------------------------L--FA---------------------- PLK2_Mmus_PLK2 ---------------------------------F--FK---------------------- PLK1_Mmus_PLK1 ---------------------------------PS-SR---------------------- plk-2_Cele_PLK1 ---------------------------------EE-NV---------------------- plk-1_Cele_PLK1 ---------------------------------EE-NV---------------------- F55G1.8_Cele_PLK1 ---------------------------------VK---Y------F-------------- CDC5_Scer_PLK1 ---------------------------------LV---N------F-------------- zyg-1_Cele_SAK ---------------------------------QR---S------R-------------- PLK_Ddis_PLK1 ---------------------------------RPLSEK------T-------------- 8635_Tthe_SAK ---------------------------------KK---N--------------------- 18358b_Tthe_PLK-Unclassified ---------------------------------ST---Q------I-------------- 18380_Tthe_PLK-Unclassified ---------------------------------KS---N------N-------------- 21183_Tthe_SAK ---------------------------------QN---N--------------------- 22503_Tthe_PLK-Unclassified ---------------------------------SE---S--------------------- 5034_Tthe_SAK NDQIAALKNNKIQNEDLNIMSNNLNQIQYKKQSQN---NLVKQNDK-------------- 8829_Tthe_PLK-Unclassified ---------------------------------QG---N------A-------------- SAK_Spur_SAK ---------------------------------TS-----------SRS----------- PLK1_Spur_PLK1 ------------------------------------GR---------------------- PLK2_Spur_PLK2 ---------------------------------DR-KG----------DLVTNEFCRLKR n1170_Tthe_PLK-Unclassified ---------------------------------SA---S------N-------------- n808_Tthe_PLK-Unclassified ------------------------------------------------------------ CC1G_07437_Ccin_PLK1 ---------------------------------EANLKR---LRRY--ALLDTDFNN--T AqueK200_Aque_PLK1 ---------------------------------VS-GR---------------------- AqueK201_Aque_SAK ------------------------------------------------------------ GK066_Glam_PLK-Unclassified ---------------------------------M--QM---------------------- PLK4_Hsap_SAK ----------RLLIGQPLPNKMTVFPKNKSSTDFSSSG--DGN---SFYTQWGN--QETS PLK3_Hsap_PLK2 ----------K-----VTK---SL------------------------------------ PLK2_Hsap_PLK2 ----------K-----AAA---AL------------------------------------ PLK1_Hsap_PLK1 ----------K-----PLT---VL------------------------------------ polo_Dmel_PLK1 ----------K-----PLM---EM------------------------------------ SAK_Dmel_SAK ------------SVENSGPQ---------------------------------------- PLK5_Mmus_PLK2 ----------K-----VGQ---LL------------------------------------ PLK4_Mmus_SAK ----------RLLVGQPLPNKITVFQKNKNSSDFS-SG--DGS---NFCTQWGNPEQEAN PLK3_Mmus_PLK2 ----------K-----VTK---SL------------------------------------ PLK2_Mmus_PLK2 ----------K-----AAA---AL------------------------------------ PLK1_Mmus_PLK1 ----------K-----PLK---VL------------------------------------ plk-2_Cele_PLK1 ----------S-----PSG---TI------------------------------------ plk-1_Cele_PLK1 ----------A-----PRG---VD------------------------------------ F55G1.8_Cele_PLK1 ----------A-----PIN----------------------------------------- CDC5_Scer_PLK1 ----------K-----DCM----------------------------------------- zyg-1_Cele_SAK ----------E-----PVR----------------------------------------- PLK_Ddis_PLK1 ----------------------NIV--N-------------------------------- 8635_Tthe_SAK ----------------------KRIS-N-------------------------------- 18358b_Tthe_PLK-Unclassified ----------------------SLST-N-------------------------------- 18380_Tthe_PLK-Unclassified ----------------------QIVQ-D-------------------------------- 21183_Tthe_SAK ----------------------KNIQ---------------------------------- 22503_Tthe_PLK-Unclassified ----------------------VLAP---------------------------------- 5034_Tthe_SAK ----------------------QILN---------------------------------- 8829_Tthe_PLK-Unclassified -----------------------LKL-N-------------------------------- SAK_Spur_SAK ----------RPMRALPLSTLTPVISEGEGSRGQ-VKGHHHGDGIGSSWNQYDR--HPPS PLK1_Spur_PLK1 ----------R-----PLL---EV------------------------------------ PLK2_Spur_PLK2 ESTLQRRDVTA-----PLS---EL------------------------------------ n1170_Tthe_PLK-Unclassified -----------------------IKA-N-------------------------------- n808_Tthe_PLK-Unclassified ------------------------------------------------------------ CC1G_07437_Ccin_PLK1 PSPVQNATTRN-----ITS---SIAQ-Q-------------------------------- AqueK200_Aque_PLK1 ----------K-----PLS---DR------------------------------------ AqueK201_Aque_SAK -----------------------VIATYRGDCQFH------------------------- GK066_Glam_PLK-Unclassified ----------T-----INM---AK------------------------------------ PLK4_Hsap_SAK NSGRGRVIQ-------------DAEERPH-----------SRYLRRAYS----------- PLK3_Hsap_PLK2 ------------------------------------------------------------ PLK2_Hsap_PLK2 ------------------------------------------------------------ PLK1_Hsap_PLK1 ------------------------------------------------------------ polo_Dmel_PLK1 ------------------------------------------------------------ SAK_Dmel_SAK -----QVLP-------------Q--IREE-----------FKQVHHK------------- PLK5_Mmus_PLK2 ------------------------------------------------------------ PLK4_Mmus_SAK SRGRGRVIE-------------DAEERPH-----------SRYLRRAHS----------- PLK3_Mmus_PLK2 ------------------------------------------------------------ PLK2_Mmus_PLK2 ------------------------------------------------------------ PLK1_Mmus_PLK1 ------------------------------------------------------------ plk-2_Cele_PLK1 ------------------------------------------------------------ plk-1_Cele_PLK1 ------------------------------------------------------------ F55G1.8_Cele_PLK1 ---------------------------P-------------------------------- CDC5_Scer_PLK1 ---------EKSLLLE-----------S-------------------MS----------- zyg-1_Cele_SAK ---------------------------S-------------------SR----------- PLK_Ddis_PLK1 ---------QQHLQLA--------------------------------GTTSPTKNNNHH 8635_Tthe_SAK -----LKNQKSLTSMK--------------------------------L----------- 18358b_Tthe_PLK-Unclassified ---------Q-------------------------------------------------- 18380_Tthe_PLK-Unclassified ---------Q-------------------------------------------------- 21183_Tthe_SAK ---------QGHTRQR--------------------------------S----------- 22503_Tthe_PLK-Unclassified ---------KSQLQLA--------------------------------N----------- 5034_Tthe_SAK ---------QKEINFA--------------------------------R----------- 8829_Tthe_PLK-Unclassified ---------QAPMRLT--------------------------------D----------- SAK_Spur_SAK PPVRQRANHSAALQSRSEQAGETLESRPWFSGAALKQKASSSQDLRMTS----------- PLK1_Spur_PLK1 ------------------------------------------------------------ PLK2_Spur_PLK2 ------------------------------------------------------------ n1170_Tthe_PLK-Unclassified ---------QQSMQIG--------------------------------T----------- n808_Tthe_PLK-Unclassified ----------RIILI---------------------------------T----------- CC1G_07437_Ccin_PLK1 ----------------EK-------------------------------------EF-QR AqueK200_Aque_PLK1 ------------------------------------------------------------ AqueK201_Aque_SAK ------------------------------------------------------------ GK066_Glam_PLK-Unclassified ------------------------------------------------------------ PLK4_Hsap_SAK ---------------------S-D-----RSGTS--NSQSQAKT---------------- PLK3_Hsap_PLK2 -------------------FGR-KKK-SK------------------------------- PLK2_Hsap_PLK2 -------------------FGG-KKDKAR---------------Y--------------- PLK1_Hsap_PLK1 -------------------NKG-LE----------------------------------- polo_Dmel_PLK1 -------------------NGI-------------------------------------- SAK_Dmel_SAK ------------------------------------------------------------ PLK5_Mmus_PLK2 -------------------LTQ-CRPPCP---------------F--------------- PLK4_Mmus_SAK ---------------------S-D-----RASPS--N-QSRAKT---------------- PLK3_Mmus_PLK2 -------------------FGR-KKNKNK------------------------------- PLK2_Mmus_PLK2 -------------------FGG-KKDKAR---------------Y--------------- PLK1_Mmus_PLK1 -------------------NKG-VE----------------------------------- plk-2_Cele_PLK1 -------------------DQ--RG----------------------------------- plk-1_Cele_PLK1 -------------------AR--SQ----------------------------------- F55G1.8_Cele_PLK1 ------------------------------------------------------------ CDC5_Scer_PLK1 ---------------------S-D-----KIQ-------RQKRD---------------- zyg-1_Cele_SAK ---------------------D-D-----R-----------SRD---------------- PLK_Ddis_PLK1 YQQYQQQPQQQYNNNYQQSF-S-------PK--------KQINN---------------- 8635_Tthe_SAK ---------------------D-------LS--------------DCNKEN-QPNLINSS 18358b_Tthe_PLK-Unclassified ----------------------------------------KSTN---------------- 18380_Tthe_PLK-Unclassified -----------------------------KI--------G-SGS---------------- 21183_Tthe_SAK ---------------------N-------FS------------------------MDSSN 22503_Tthe_PLK-Unclassified ---------------------N-------GA---------QPYDYNCQNENQTPHISTTQ 5034_Tthe_SAK -----------------------------KN------------------------SPVDR 8829_Tthe_PLK-Unclassified ---------------------S-------AS--------QSTTN---------------- SAK_Spur_SAK ---------------------S-D-----RMQPHVSSHTSQTRD---------------- PLK1_Spur_PLK1 -------------------NGQ-DE----------------------------------- PLK2_Spur_PLK2 -------------------INNDSS----------------------------------- n1170_Tthe_PLK-Unclassified -----------------EVFGS-SRKEMTKS--------QTTTN---------------- n808_Tthe_PLK-Unclassified -----------------LS----------------------------------------- CC1G_07437_Ccin_PLK1 AVQP-GSPISA-------LLSS-ARQPLL---------------V-GP------------ AqueK200_Aque_PLK1 -------------------N---------------------------------------- AqueK201_Aque_SAK ------------------------------------------------------------ GK066_Glam_PLK-Unclassified -------------------NAG-GT----------------------------------- PLK4_Hsap_SAK ----YT-----------MERCHSAEMLSVSKRSG------GGEN-----EERYS------ PLK3_Hsap_PLK2 ------------------------------------------------------------ PLK2_Hsap_PLK2 ------------------------------------------------------------ PLK1_Hsap_PLK1 ------------------------------------------------------------ polo_Dmel_PLK1 ------------------------------------------------------------ SAK_Dmel_SAK ------------------LPYEQTGLFGQAS----------------------------- PLK5_Mmus_PLK2 ------------------------------------------------------------ PLK4_Mmus_SAK ----YS-----------VERCHSVEMLSKPRR---------------------------- PLK3_Mmus_PLK2 ------------------------------------------------------------ PLK2_Mmus_PLK2 ------------------------------------------------------------ PLK1_Mmus_PLK1 ------------------------------------------------------------ plk-2_Cele_PLK1 ------------------------------------------------------------ plk-1_Cele_PLK1 ------------------------------------------------------------ F55G1.8_Cele_PLK1 ------------------------------------------------------------ CDC5_Scer_PLK1 ----YI-----------S------------------------------------------ zyg-1_Cele_SAK ------------------------------------------------------------ PLK_Ddis_PLK1 ----MN-----------N--------------NNN-----NNNNNNN--NN----NN--- 8635_Tthe_SAK NNKS--------------------------------------NNTA-------------- 18358b_Tthe_PLK-Unclassified ----YQ-----------V--------------EN---------------KN----S---- 18380_Tthe_PLK-Unclassified ----LA-------------------------------------------ST----QS--- 21183_Tthe_SAK NSKHFQQNKIMNDNLYQI--------------NNINRSNQIQENNVLQNKQ----T---- 22503_Tthe_PLK-Unclassified STKHFQRSN-----------------------------------HFYQTQS----S---- 5034_Tthe_SAK FDV--------------------------------------------------------- 8829_Tthe_PLK-Unclassified ----IK-----------G--------------KN---------------AS----TS--- SAK_Spur_SAK ----YN-----------LTAKPS--------IND------GSMK-------GFDTKTRGM PLK1_Spur_PLK1 ------------------------------------------------------------ PLK2_Spur_PLK2 ------------------------------------------------------------ n1170_Tthe_PLK-Unclassified ----MN------KALFQN--------------ENGNKVLDGQKN-----QA----TS--- n808_Tthe_PLK-Unclassified --------------------------------------FDSKKQ-----S-----DR--- CC1G_07437_Ccin_PLK1 ------------T-------------------AG------GG------------------ AqueK200_Aque_PLK1 ------------------------------------------------------------ AqueK201_Aque_SAK ----------------------GSRVLKNIQ----------------------------- GK066_Glam_PLK-Unclassified ------------------------------------------------------------ PLK4_Hsap_SAK PTDNNA-------------------------NIF----NFFKEKT-SSSSGSFERPDNNQ PLK3_Hsap_PLK2 ------------------------------------------------------------ PLK2_Hsap_PLK2 ------------------------------------------------------------ PLK1_Hsap_PLK1 ------------------------------------------------------------ polo_Dmel_PLK1 ------------------------------------------------------------ SAK_Dmel_SAK --------------------------------------T------------GLAEPNW-- PLK5_Mmus_PLK2 ------------------------------------------------------------ PLK4_Mmus_SAK ---------------------------------------------------SL---DENQ PLK3_Mmus_PLK2 ------------------------------------------------------------ PLK2_Mmus_PLK2 ------------------------------------------------------------ PLK1_Mmus_PLK1 ------------------------------------------------------------ plk-2_Cele_PLK1 ------------------------------------------------------------ plk-1_Cele_PLK1 ------------------------------------------------------------ F55G1.8_Cele_PLK1 ------------------------------------------------------------ CDC5_Scer_PLK1 ------------------------------------------------------------ zyg-1_Cele_SAK ------------------------------------------------------------ PLK_Ddis_PLK1 ------------------------------------------------------------ 8635_Tthe_SAK ------------------------------------------------------------ 18358b_Tthe_PLK-Unclassified ------------------------------------------------------------ 18380_Tthe_PLK-Unclassified ------------------------------------------------------------ 21183_Tthe_SAK ------------------------------------------------------------ 22503_Tthe_PLK-Unclassified ------------------------------------------------------------ 5034_Tthe_SAK ------------------------------------------------------------ 8829_Tthe_PLK-Unclassified ------------------------------------------------------------ SAK_Spur_SAK YQSHEQDIHRSQGHVYHDDAQVKRSGSWKSQEFLGQHGSVLREKSRTETSGHYDRVDD-- PLK1_Spur_PLK1 ------------------------------------------------------------ PLK2_Spur_PLK2 ------------------------------------------------------------ n1170_Tthe_PLK-Unclassified ------------------------------------------------------------ n808_Tthe_PLK-Unclassified ------------------------------------------------------------ CC1G_07437_Ccin_PLK1 -----------------------------------------------------GNPGA-- AqueK200_Aque_PLK1 ------------------------------------------------------------ AqueK201_Aque_SAK ------------------------------------------------------------ GK066_Glam_PLK-Unclassified ------------------------------------------------------------ PLK4_Hsap_SAK ALSNHLCPGKTPFPFADPTPQTETVQQWFGNLQINAHLRKTTEYDSISPNRDFQGHPDLQ PLK3_Hsap_PLK2 ------------------------------------------------------------ PLK2_Hsap_PLK2 ------------------------------------------------------------ PLK1_Hsap_PLK1 ------------------------------------------------------------ polo_Dmel_PLK1 ------------------------------------------------------------ SAK_Dmel_SAK ----------------------------PGAAK--------------------------- PLK5_Mmus_PLK2 ------------------------------------------------------------ PLK4_Mmus_SAK HSSNHHCLGKTPFPFADQTPQMEMVQQWFGNLQMNAHLGETNEHHTVSPNRDFQDYPDLQ PLK3_Mmus_PLK2 ------------------------------------------------------------ PLK2_Mmus_PLK2 ------------------------------------------------------------ PLK1_Mmus_PLK1 ------------------------------------------------------------ plk-2_Cele_PLK1 ------------------------------------------------------------ plk-1_Cele_PLK1 ------------------------------------------------------------ F55G1.8_Cele_PLK1 ------------------------------------------------------------ CDC5_Scer_PLK1 ------------------------------------------------------------ zyg-1_Cele_SAK ------------------------------------------------------------ PLK_Ddis_PLK1 ------------------------------------------------------------ 8635_Tthe_SAK ------------------------------------------------------------ 18358b_Tthe_PLK-Unclassified ------------------------------------------------------------ 18380_Tthe_PLK-Unclassified ------------------------------------------------------------ 21183_Tthe_SAK ------------------------------------------------------------ 22503_Tthe_PLK-Unclassified ------------------------------------------------------------ 5034_Tthe_SAK ------------------------------------------------------------ 8829_Tthe_PLK-Unclassified ------------------------------------------------------------ SAK_Spur_SAK -----------------------------------AKHRLFSEADIDS--DRRQ-DLTVR PLK1_Spur_PLK1 ------------------------------------------------------------ PLK2_Spur_PLK2 ------------------------------------------------------------ n1170_Tthe_PLK-Unclassified ------------------------------------------------------------ n808_Tthe_PLK-Unclassified ------------------------------------------------------------ CC1G_07437_Ccin_PLK1 -------VRESPLL-----------------------RKLQAVKE--------------- AqueK200_Aque_PLK1 ------------------------------------------------------------ AqueK201_Aque_SAK ------------------------------------------------------------ GK066_Glam_PLK-Unclassified ------------------------------------------------------------ PLK4_Hsap_SAK KDTSKNAWTDTKVKKNSDASDNAHSV----------------K---Q-----Q--NTMKY PLK3_Hsap_PLK2 ---------------------------------------------N-HAQ---------- PLK2_Hsap_PLK2 -----------------------------------------IDTHNRVSK---------- PLK1_Hsap_PLK1 ------------------------------------------------------------ polo_Dmel_PLK1 ------------------------------------------------------------ SAK_Dmel_SAK ------------------------------------------------------------ PLK5_Mmus_PLK2 -----------------------------------------TSK--EASG---------- PLK4_Mmus_SAK -DTLRNAWTDTRASKNADTSANVHAV----------------K---Q-----L--SAMKY PLK3_Mmus_PLK2 ---------------------------------------------N-HSE---------- PLK2_Mmus_PLK2 -----------------------------------------NDTHNKVSK---------- PLK1_Mmus_PLK1 ------------------------------------------------------------ plk-2_Cele_PLK1 ------------------------------------------------------------ plk-1_Cele_PLK1 ------------------------------------------------------------ F55G1.8_Cele_PLK1 -------------------------V----------------L----------------- CDC5_Scer_PLK1 --------------------SIKSSI----------------D---K-----L--E---- zyg-1_Cele_SAK ----------------------GRAL----------------I---R-----S--S---- PLK_Ddis_PLK1 --------------------NNNNNNNNLKQYNYSNNNINYNNNNNNINNQFA--N---- 8635_Tthe_SAK ------------------------------------------------------------ 18358b_Tthe_PLK-Unclassified --------------------SPK-KF----------------D----------------- 18380_Tthe_PLK-Unclassified --------------------QMNMAA----------------T---Q-----S--G---- 21183_Tthe_SAK --------------------KE-NRF----------------Q---S-----K--E---- 22503_Tthe_PLK-Unclassified --------------------ST-ANF----------------K---P-----T--S---- 5034_Tthe_SAK ----------------------------------------------------ENQQ---- 8829_Tthe_PLK-Unclassified --------------------NLYSKQ----------------T---T-----T--G---- SAK_Spur_SAK TDHAKDKCTDKKQSA-------------------------------Q-----S--SVSDH PLK1_Spur_PLK1 ------------------------------------------------------------ PLK2_Spur_PLK2 ------------------------------------------------------------ n1170_Tthe_PLK-Unclassified --------------------NPSNQF----------------M---S-----T--A---- n808_Tthe_PLK-Unclassified ------------------------------------------------------------ CC1G_07437_Ccin_PLK1 --------------------SPLGR-RSV-------------TR-T-ANG-Y-------- AqueK200_Aque_PLK1 ------------------------------------------------------------ AqueK201_Aque_SAK ------------------------------------------------------------ GK066_Glam_PLK-Unclassified ------------------------------------------------------------ PLK4_Hsap_SAK MTALHSKPEIIQ--Q-E------------------------------------------- PLK3_Hsap_PLK2 ---------------------------------ERDEV--SGLVSGL---MRTSVGH--Q PLK2_Hsap_PLK2 ---------------------------------EDEDI--YKLRHDL---KKTSITQ--Q PLK1_Hsap_PLK1 -----------------------------------------------------------N polo_Dmel_PLK1 -----------------------------------------------------------R SAK_Dmel_SAK -------SS--------------------------------------------------- PLK5_Mmus_PLK2 ---------------------------------PGEE------------------GT--E PLK4_Mmus_SAK MSAHHHKPEVMP--Q-E------------------------------------------- PLK3_Mmus_PLK2 ---------------------------------DQDNV--SCLVSGL---MRTSIGH--P PLK2_Mmus_PLK2 ---------------------------------EDEDI--YKLRHDL---KKVSITQ--Q PLK1_Mmus_PLK1 -----------------------------------------------------------N plk-2_Cele_PLK1 -----------------------------------------------------------P plk-1_Cele_PLK1 -----------------------------------------------------------R F55G1.8_Cele_PLK1 -----------P--H-VE-------E---------------------------------- CDC5_Scer_PLK1 -EYHQNRP-FLP--H-SL-------S---------------------------------- zyg-1_Cele_SAK ---------SQPAHS-GR-------A---------------------------------- PLK_Ddis_PLK1 ---------L--SPN-SQ-------QKLSEV--ENDDFHYRKLRR-LEKMKEN------- 8635_Tthe_SAK ---------I--IEKQK-STK----SN--------------------------------- 18358b_Tthe_PLK-Unclassified ----------------NT-------T---------------------------------- 18380_Tthe_PLK-Unclassified ---------L--QLN-GT-------K---------------------------------- 21183_Tthe_SAK ------------------------------------------------------------ 22503_Tthe_PLK-Unclassified ---------L--SQQHATTNS----N---------------------------------- 5034_Tthe_SAK ------------------------------------------------------------ 8829_Tthe_PLK-Unclassified ---------A--VPD-AS-------R---------------------------------- SAK_Spur_SAK PSVHGMH-AAVP--S-SA-------S---------------------------------- PLK1_Spur_PLK1 -----------------------------------------------------------N PLK2_Spur_PLK2 -----------------------------------------------------------K n1170_Tthe_PLK-Unclassified ---------N--LQQ-NS-------K---------------------------------- n808_Tthe_PLK-Unclassified ------------------------------------------------------------ CC1G_07437_Ccin_PLK1 ------------E-----EDERGKRRMVIETEEEEEDM--RQRRKELE-AQKARIVAQMA AqueK200_Aque_PLK1 ------------------------------------------------------------ AqueK201_Aque_SAK ------------------------------------------------------------ GK066_Glam_PLK-Unclassified ------------------------------------------------------------ PLK4_Hsap_SAK -----------------------------------------------------------C PLK3_Hsap_PLK2 ------------------------------------------------------------ PLK2_Hsap_PLK2 P---S---KHR-T----------------------------------------------- PLK1_Hsap_PLK1 P---L---PER-P----------------------------------------------- polo_Dmel_PLK1 P---D---DTR-L----------------------------------------------- SAK_Dmel_SAK -----------------------------------------------------------A PLK5_Mmus_PLK2 P---D---HME-A----------------------------------------------- PLK4_Mmus_SAK ------------------------------------------------------------ PLK3_Mmus_PLK2 ------------------------------------------------------------ PLK2_Mmus_PLK2 P---S---KHR-A----------------------------------------------- PLK1_Mmus_PLK1 P---L---PDR-P----------------------------------------------- plk-2_Cele_PLK1 H---Q---AGR-S----------------------------------------------- plk-1_Cele_PLK1 P---L---NGR-A----------------------------------------------- F55G1.8_Cele_PLK1 P---I-----------------------------S----------------PIYQE---V CDC5_Scer_PLK1 P---G----G---T--------------------K----------------QKYKE---V zyg-1_Cele_SAK P---L-----------------------------S----------------NRPIH---D PLK_Ddis_PLK1 D---L---KT---Q--------------------L----------------LIKQQYT-N 8635_Tthe_SAK T---Y---KE---QQNIQ-SN-QQNSLGMSNIFLTTARSINLADNSIIMSTLQDNQLNNT 18358b_Tthe_PLK-Unclassified P---I---NGN-GF--------------------T----------------RFATQ-T-S 18380_Tthe_PLK-Unclassified D---L---NG---N---------------------------------------------- 21183_Tthe_SAK ---------------QLLVNENKEN--------IH----------------SN--ILNSI 22503_Tthe_PLK-Unclassified N---L---QD---TNSTN-TNENNT--------ISS-------------NNPNN-NEINI 5034_Tthe_SAK ---------------NN-MNKQKDD--------A-------------------------- 8829_Tthe_PLK-Unclassified P---L---GG---T--------------------T----------------SNWNQ---V SAK_Spur_SAK C---G----G---L--------------------S----------------SKQDG---A PLK1_Spur_PLK1 V---P---PGR-E----------------------------------------------- PLK2_Spur_PLK2 Q---G---SGT-T----------------------------------------------- n1170_Tthe_PLK-Unclassified N---L-----------------------------N----------------SNFNQ-N-D n808_Tthe_PLK-Unclassified ------------------------------------------------------------ CC1G_07437_Ccin_PLK1 P---V---K--------------------------------------------------- AqueK200_Aque_PLK1 P---M---TDA-M----------------------------------------------- AqueK201_Aque_SAK ------------------------------------------------------------ GK066_Glam_PLK-Unclassified DGRFIAATPQAIG----------------------------------------------- PLK4_Hsap_SAK V----------------------------------------------------------- PLK3_Hsap_PLK2 ---DARP----------------------------------------------------- PLK2_Hsap_PLK2 ---DEEL----------------------------------------------------- PLK1_Hsap_PLK1 ---REK------------------------------------------------------ polo_Dmel_PLK1 ---EST------------------------------------------------------ SAK_Dmel_SAK FC--ME------------------------------------------------------ PLK5_Mmus_PLK2 ---GNEE----------------------------------------------------- PLK4_Mmus_SAK ------------------------------------------------------------ PLK3_Mmus_PLK2 ---DVRP----------------------------------------------------- PLK2_Mmus_PLK2 ---DEEP----------------------------------------------------- PLK1_Mmus_PLK1 ---REK------------------------------------------------------ plk-2_Cele_PLK1 ---GLS------------------------------------------------------ plk-1_Cele_PLK1 ---GLS------------------------------------------------------ F55G1.8_Cele_PLK1 AN--EE------------------------------------------------------ CDC5_Scer_PLK1 VD--IEA----------------------------------------------------- zyg-1_Cele_SAK RM--PS------------------------------------------------------ PLK_Ddis_PLK1 MNENQQQ----------------------------------------------------- 8635_Tthe_SAK NN--K-KENTKPTQK--------LQYYLQQNSNTSQQL-KQ----------SSILNNQGQ 18358b_Tthe_PLK-Unclassified YN--PQN----------------------------------------------------- 18380_Tthe_PLK-Unclassified ------------------------------------------------------------ 21183_Tthe_SAK NN--Q-QKLFQQQQKLNPIPLQKSYSYNQKNE-----Q-KQ----------DQILH-QTL 22503_Tthe_PLK-Unclassified AN--QENDNY-QLLRM---------------------R-SQENIQFSRQFQNYF------ 5034_Tthe_SAK ---------------SHTVKVKEIHSHNQQLN-----IRKQ----------S-PTN-QIL 8829_Tthe_PLK-Unclassified SS--QKD----------------------------------------------------- SAK_Spur_SAK LH--KDS----------------------------------------------------- PLK1_Spur_PLK1 ---Q-S------------------------------------------------------ PLK2_Spur_PLK2 --SQNS------------------------------------------------------ n1170_Tthe_PLK-Unclassified FN--QTD----------------------------------------------------- n808_Tthe_PLK-Unclassified ------------------------------------------------------------ CC1G_07437_Ccin_PLK1 --E---------------------------------------------EVE--------- AqueK200_Aque_PLK1 ---DTA------------------------------------------------------ AqueK201_Aque_SAK ------------------------------------------------------------ GK066_Glam_PLK-Unclassified ---GTE------------------------------------------------------ PLK4_Hsap_SAK ------------------------------------------------------------ PLK3_Hsap_PLK2 ------------------------------------------------------------ PLK2_Hsap_PLK2 ------------------------------------------------------------ PLK1_Hsap_PLK1 ------------------------------------------------------------ polo_Dmel_PLK1 ------------------------------------------------------------ SAK_Dmel_SAK ------------------------------------------------------------ PLK5_Mmus_PLK2 ------------------------------------------------------------ PLK4_Mmus_SAK ------------------------------------------------------------ PLK3_Mmus_PLK2 ------------------------------------------------------------ PLK2_Mmus_PLK2 ------------------------------------------------------------ PLK1_Mmus_PLK1 ------------------------------------------------------------ plk-2_Cele_PLK1 ------------------------------------------------------------ plk-1_Cele_PLK1 ------------------------------------------------------------ F55G1.8_Cele_PLK1 ------------------------------------------------------------ CDC5_Scer_PLK1 ------------------------------------------------------------ zyg-1_Cele_SAK ------------------------------------------------------------ PLK_Ddis_PLK1 ------------------------------------------------------------ 8635_Tthe_SAK ASG-------YNNSRN--RFDLSCNNVINQNKSQQSLLQYNGYKSQSVIPQQQQAFSQNS 18358b_Tthe_PLK-Unclassified ------------------------------------------------------------ 18380_Tthe_PLK-Unclassified ------------------------------------------------------------ 21183_Tthe_SAK AQG-------LKKEVSEQS--------IDN-----------NRNKQII--QEIQNISQNS 22503_Tthe_PLK-Unclassified -QG-------KKE--------------------------------NSL--QKYPSSQQFT 5034_Tthe_SAK NYDKDKIAIPERKSLTQQS--------QAI-----------NQND--------------- 8829_Tthe_PLK-Unclassified ------------------------------------------------------------ SAK_Spur_SAK ------------------------------------------------------------ PLK1_Spur_PLK1 ------------------------------------------------------------ PLK2_Spur_PLK2 ------------------------------------------------------------ n1170_Tthe_PLK-Unclassified ------------------------------------------------------------ n808_Tthe_PLK-Unclassified ------------------------------------------------------------ CC1G_07437_Ccin_PLK1 ----------RE----------------------EREDEDDEEEDEDGM----------- AqueK200_Aque_PLK1 ------------------------------------------------------------ AqueK201_Aque_SAK ------------------------------------------------------------ GK066_Glam_PLK-Unclassified ------------------------------------------------------------ PLK4_Hsap_SAK ------------------------------------------------------------ PLK3_Hsap_PLK2 -----------------------------------EAPAAS-GP-----AP--------- PLK2_Hsap_PLK2 -----------------------------------QPPTTTVAR-----SG--------- PLK1_Hsap_PLK1 -----------------------------------EEP---------------------- polo_Dmel_PLK1 -----------------------------------FLK---------------------- SAK_Dmel_SAK ------------------------------------------------------------ PLK5_Mmus_PLK2 -----------------------------------RDPLCTEG----------------- PLK4_Mmus_SAK ------------------------------------------------------------ PLK3_Mmus_PLK2 -----------------------------------EAPVVS-GQ-----AP--------- PLK2_Mmus_PLK2 -----------------------------------QPPPTTVAR-----SG--------- PLK1_Mmus_PLK1 -----------------------------------EEP---------------------- plk-2_Cele_PLK1 -----------------------------------AIP---------------------- plk-1_Cele_PLK1 -----------------------------------ALP---------------------- F55G1.8_Cele_PLK1 ------------------------------------------------------------ CDC5_Scer_PLK1 -----------------------------------QRRLN-------------------- zyg-1_Cele_SAK ------------------------------------------------------------ PLK_Ddis_PLK1 -----------------------------------QQQQQ-------------------- 8635_Tthe_SAK Q-------------------------------QISNKNQP-------------------- 18358b_Tthe_PLK-Unclassified -----------------------------------VKS-Q-------------------- 18380_Tthe_PLK-Unclassified -----------------------------------MRS-Q-------------------- 21183_Tthe_SAK Y--------------------------YN-P-QISQSNKQ-------------------- 22503_Tthe_PLK-Unclassified ---------------------------GN-P-IS--SN---------------------- 5034_Tthe_SAK VFKSPKLTSNQQEIKQTFINNIEKIKSNQ-P-PVPQ-NQQ-------------------- 8829_Tthe_PLK-Unclassified -----------------------------------QRPQT-------------------- SAK_Spur_SAK ------------------------------------------------------------ PLK1_Spur_PLK1 -----------------------------------GKP---------------------- PLK2_Spur_PLK2 -----------------------------------GKP------------SSQPKLRTRI n1170_Tthe_PLK-Unclassified -----------------------------------QRPTT-------------------- n808_Tthe_PLK-Unclassified -------------------------------------QS--------------------- CC1G_07437_Ccin_PLK1 -------------------GGRRR----APPPPPP-----VFKREREHQK---------- AqueK200_Aque_PLK1 ------------------------------------GG---------------------- AqueK201_Aque_SAK ------------------------------------------------------------ GK066_Glam_PLK-Unclassified -----------------------------------HIPTP-------------------- PLK4_Hsap_SAK -------------------------------------------------------FGSDP PLK3_Hsap_PLK2 ----------------------------------------------V--S-LVETA---- PLK2_Hsap_PLK2 ----------------------------------------------T--P-AVENK---- PLK1_Hsap_PLK1 ---------------------------------------------------VV-R----- polo_Dmel_PLK1 ----------------------------------------------A--N-LHD------ SAK_Dmel_SAK -------------------------------------------------------AGNVP PLK5_Mmus_PLK2 ------------------------------------------------------------ PLK4_Mmus_SAK -------------------------------------------------------PGLHP PLK3_Mmus_PLK2 ----------------------------------------------A--S-LVETA---- PLK2_Mmus_PLK2 ----------------------------------------------T--S-AVENK---- PLK1_Mmus_PLK1 ---------------------------------------------------VV-R----- plk-2_Cele_PLK1 ----------------------------------------------A--H-LVSRN---- plk-1_Cele_PLK1 ----------------------------------------------Q--H-IVSNN---- F55G1.8_Cele_PLK1 ------------------------------------------------------TSEI-- CDC5_Scer_PLK1 ----------------------------------------------D--L--AREARI-R zyg-1_Cele_SAK ------------------------------------------------------TSSRGF PLK_Ddis_PLK1 ----------------------------------------------Q--Q-QQQ-----Q 8635_Tthe_SAK ----------------------------------------------Q--Q--QN------ 18358b_Tthe_PLK-Unclassified ----------------------------------------------Q--Q--MG-----L 18380_Tthe_PLK-Unclassified ----------------------------------------------S------------- 21183_Tthe_SAK ----------------------------------------------Q--Q--QQ-----I 22503_Tthe_PLK-Unclassified -------------------------------------------------Q--NI-----L 5034_Tthe_SAK ----------------------------------------------QQNN--SA-----I 8829_Tthe_PLK-Unclassified ----------------------------------------------Q--Q--FQ-----K SAK_Spur_SAK ------------------------------------------------------KAGERS PLK1_Spur_PLK1 ---------------------------------------------------HR-KH---- PLK2_Spur_PLK2 TGS------------------------------------RPMTPVTS--A-IKTAM---- n1170_Tthe_PLK-Unclassified ----------------------------------------------S--K--VQ-----T n808_Tthe_PLK-Unclassified ------------------------------------------------------------ CC1G_07437_Ccin_PLK1 -GSSAGSNRYAGEDVENVPPRLGGAQQARRDVAKGKAVERPRAREK-------------- AqueK200_Aque_PLK1 ---------------------------------------------------VL-KP---- AqueK201_Aque_SAK --------------------------------------------------------LEAP GK066_Glam_PLK-Unclassified ----------------------------------------------G--TANFYKP---- PLK4_Hsap_SAK ------------------------------------------------------------ PLK3_Hsap_PLK2 ------------------------------------------------------------ PLK2_Hsap_PLK2 ------------------------------------------------------------ PLK1_Hsap_PLK1 ------------------------------------------------------------ polo_Dmel_PLK1 ------------------------------------------------------------ SAK_Dmel_SAK ------------------------------------------------------------ PLK5_Mmus_PLK2 ------------------------------------------------------------ PLK4_Mmus_SAK ------------------------------------------------------------ PLK3_Mmus_PLK2 ------------------------------------------------------------ PLK2_Mmus_PLK2 ------------------------------------------------------------ PLK1_Mmus_PLK1 ------------------------------------------------------------ plk-2_Cele_PLK1 ------------------------------------------------------------ plk-1_Cele_PLK1 ------------------------------------------------------------ F55G1.8_Cele_PLK1 ------------------------------------------------------------ CDC5_Scer_PLK1 ------------------------------------------------------------ zyg-1_Cele_SAK ------------------------------------------------------------ PLK_Ddis_PLK1 ------------------------------------------------------------ 8635_Tthe_SAK ------------------------------------------------------------ 18358b_Tthe_PLK-Unclassified ------------------------------------------------------------ 18380_Tthe_PLK-Unclassified ------------------------------------------------------------ 21183_Tthe_SAK D----------------------------------------------------------- 22503_Tthe_PLK-Unclassified N----------------------------------------------------------- 5034_Tthe_SAK TTYGGQEKRGVKSIVYNNSNNQNNINTNQNSNQYNIQNSITNNQINPTNNYKTVNSSNIN 8829_Tthe_PLK-Unclassified ------------------------------------------------------------ SAK_Spur_SAK ------------------------------------------------------------ PLK1_Spur_PLK1 ------------------------------------------------------------ PLK2_Spur_PLK2 ------------------------------------------------------------ n1170_Tthe_PLK-Unclassified ------------------------------------------------------------ n808_Tthe_PLK-Unclassified ------------------------------------------------------------ CC1G_07437_Ccin_PLK1 ----------------------ENVP---------------------------------- AqueK200_Aque_PLK1 ------------------------------------------------------------ AqueK201_Aque_SAK ------------------------------------------------------------ GK066_Glam_PLK-Unclassified ------------------------------------------------------------ PLK4_Hsap_SAK ----------------------------------------------LSEQ-S--KTRG-M PLK3_Hsap_PLK2 ----------------------------------------------P--E-D-----S-S PLK2_Hsap_PLK2 ----------------------------------------------QQIG-D--AIRM-I PLK1_Hsap_PLK1 ------------------------------------------------------------ polo_Dmel_PLK1 ------------------------------------------------------A--I-T SAK_Dmel_SAK ----------------------------------------------NSKQ-A--SLKE-- PLK5_Mmus_PLK2 -----------------------------------------------R-------IH--- PLK4_Mmus_SAK ----------------------------------------------HSEQ-S--KNRS-M PLK3_Mmus_PLK2 ----------------------------------------------A--E-D-----S-S PLK2_Mmus_PLK2 ----------------------------------------------QQIG-D--AIRM-I PLK1_Mmus_PLK1 ------------------------------------------------------------ plk-2_Cele_PLK1 -------------------------------------------------S-ERQ------ plk-1_Cele_PLK1 -------------------------------------------------A-DRER--A-Q F55G1.8_Cele_PLK1 -------------------------------------------------R-R--FVKT-E CDC5_Scer_PLK1 ----------------------------------------------RAQQ-A--VLRK-E zyg-1_Cele_SAK ----------------------------------------------DSER-G--RERD-R PLK_Ddis_PLK1 ----------------------------------------------QQQQ-Q--RVNN-N 8635_Tthe_SAK ------------------------------------------TKELTPKQFN-------- 18358b_Tthe_PLK-Unclassified ----------------------------------------------KERK-D--YINT-Y 18380_Tthe_PLK-Unclassified ---------------------------------------------------------N-K 21183_Tthe_SAK ------------------------------------------TIQQKPQS-K--TI---- 22503_Tthe_PLK-Unclassified -------------------------------------------QHQSPP--K--NLN--- 5034_Tthe_SAK NNYYSNTSQSQQFINGINHQHDIHSRTAANSNHDKYIKNTNNIRNNSPVN---------- 8829_Tthe_PLK-Unclassified ----------------------------------------------SDFK-T--SMST-K SAK_Spur_SAK ----------------------------------------------SHRR-S--KSKS-H PLK1_Spur_PLK1 -------------------------------------------------S-D--R--K-E PLK2_Spur_PLK2 -------------------------------------------------V-N--V--IEK n1170_Tthe_PLK-Unclassified ----------------------------------------------GT-Q-Q--GLYN-K n808_Tthe_PLK-Unclassified ------------------------------------------------------------ CC1G_07437_Ccin_PLK1 ------------------------------------------------------------ AqueK200_Aque_PLK1 -------------------------------------------------G-G--G--A-T AqueK201_Aque_SAK ----------------------------------------------ASVD-S-------- GK066_Glam_PLK-Unclassified -------------------------------------------------Q-N--A----- PLK4_Hsap_SAK EPP---W--------------------------GYQNRTLRSITSPLVAHRLKPIRQKTK PLK3_Hsap_PLK2 PRGTLAS----------------------------------------------------- PLK2_Hsap_PLK2 VRGTLGS----------------------------------------------------- PLK1_Hsap_PLK1 ------E----------------------------------------------------- polo_Dmel_PLK1 ASAQVCR----------------------------------------------------- SAK_Dmel_SAK ---------------------------------------DRISVPPLNTKRLLPTRYKTK PLK5_Mmus_PLK2 -LLTLGT----------------------------------------------------- PLK4_Mmus_SAK EST---L--------------------------GYQKPTLRSITSPLIAHRLKPIRQKTK PLK3_Mmus_PLK2 PRGTLAS----------------------------------------------------- PLK2_Mmus_PLK2 VRGTLGS----------------------------------------------------- PLK1_Mmus_PLK1 ------E----------------------------------------------------- plk-2_Cele_PLK1 QTHRMEA----------------------------------------------------- plk-1_Cele_PLK1 QQAAEAT----------------------------------------------------- F55G1.8_Cele_PLK1 QAS--------------------------------------------------------- CDC5_Scer_PLK1 LIA---T----------------------------------------------------- zyg-1_Cele_SAK DSG---R----------------------------------------------------- PLK_Ddis_PLK1 INN---N--------------------------G-------------------------- 8635_Tthe_SAK ------------------------------------------------------------ 18358b_Tthe_PLK-Unclassified RTGGAQT--------------------------S-------------------------- 18380_Tthe_PLK-Unclassified NLG--------------------------------------------------------- 21183_Tthe_SAK ---------------------------------L-------------------------- 22503_Tthe_PLK-Unclassified -TA---A--------------------------G-------------------------- 5034_Tthe_SAK ---------------------------------N-------------------------- 8829_Tthe_PLK-Unclassified NMG---S--------------------------G-------------------------- SAK_Spur_SAK DLD---KGSEWTHRHTRKHEKREGGGGGGKGEGGAGVQSLAHLTPPLNATRLRPIRQRTR PLK1_Spur_PLK1 NGGGKPK----------------------------------------------------- PLK2_Spur_PLK2 RSAAVTM----------------------------------------------------- n1170_Tthe_PLK-Unclassified Q-Q---T--------------------------G-------------------------- n808_Tthe_PLK-Unclassified ------------------------------------------------------------ CC1G_07437_Ccin_PLK1 ----VSS----------------------------------------------------- AqueK200_Aque_PLK1 ATHFVEK----------------------------------------------------- AqueK201_Aque_SAK ------------------------------------------------------------ GK066_Glam_PLK-Unclassified ---ILTT----------------------------------------------------- PLK4_Hsap_SAK KAV---VSILD-SE--------------E--VCVELVKE--YA-SQEYVKE--------- PLK3_Hsap_PLK2 -------------S--GD--GFEEGLTV-------------AT-VVESALCAL------- PLK2_Hsap_PLK2 ---------CS-SS--SE--CLE-DSTM-------------GS-VADTVARVL------- PLK1_Hsap_PLK1 ---------TG-EV--VD--C-----------------------HLSDMLQQL------- polo_Dmel_PLK1 ---------HS-ED--YR--S-----------------------DIESLYQQL------- SAK_Dmel_SAK NAI---MSILR-NG--------------E--VVLEFLKFRPTY-NEDRIND--------- PLK5_Mmus_PLK2 ---------PR-TG--LA--GP-KG-SL-------------AL-QLEVATRKL------- PLK4_Mmus_SAK KAV---VSILD-SE--------------E--VCVELLRE--CA-SEGYVKE--------- PLK3_Mmus_PLK2 -------------S--GD--GFEEGLTV-------------AT-VVESALCAL------- PLK2_Mmus_PLK2 ---------CS-SS--SE--CLE-DSTM-------------GS-VADTVARVL------- PLK1_Mmus_PLK1 ---------TN-EA--IE--C-----------------------HLSDLLQQL------- plk-2_Cele_PLK1 ---------YR-QP--TD--C-----------------------YLSNLLAQV------- plk-1_Cele_PLK1 ---------FR-EP--ED--A-----------------------YLSQLFHQV------- F55G1.8_Cele_PLK1 ------S--FG-DE--------------------------LSQ-LQAQISH--------- CDC5_Scer_PLK1 --S---TNVIK-SE--------------I--S--------LRI-LASECHL--------- zyg-1_Cele_SAK --G---T--VP-PS--------------------------REDRNRSQL----------- PLK_Ddis_PLK1 --N-----TVT-VT--T---GN------N-TV--------NVQ--IKELETK-I------ 8635_Tthe_SAK --------PYLSQ----------------------------------------------- 18358b_Tthe_PLK-Unclassified --S---SSGLCNSQ--Y---GQK-NFDTNNVN--------NQK--IDNFLQTNK------ 18380_Tthe_PLK-Unclassified --S----------------------------N--------QMD--QANLLKM-Q------ 21183_Tthe_SAK --NTFLNK---ATK--SNSL--------------------HQS--S----ST-TPSSNQQ 22503_Tthe_PLK-Unclassified --YSSVEKPSYSQS--SQTKV-------P--T--------LTS--SQKFD--------IK 5034_Tthe_SAK --NSYIER--NQSPNTQNNH--------------------MSS--SSVLNNG-QQ-QSQH 8829_Tthe_PLK-Unclassified --S---QNPLFNQT--N---A-------P--G--------LAT--AQSLNTF-T------ SAK_Spur_SAK NAV---VSIML-GG--------------E--VCLEFLKT--KD-GQDRVVE--------- PLK1_Spur_PLK1 ---------VY-QP--KE--D-----------------------HLASLKVHL------- PLK2_Spur_PLK2 ---------VK-SA--SI--C-----------------------SMDKVYEML------- n1170_Tthe_PLK-Unclassified --T---QDPNNKQQ--Q---G-------N--K--------YQS--VQNLMSM-N------ n808_Tthe_PLK-Unclassified ------------------------------------------------------------ CC1G_07437_Ccin_PLK1 ------SNP-----------AP-AAPKLN---------------GFDAAAQIL------- AqueK200_Aque_PLK1 ---------IQ-GS--ED--W-----------------------HLNSLLLQL------- AqueK201_Aque_SAK ------------------------------------------------------------ GK066_Glam_PLK-Unclassified ----------K-SA--AG--I-----------------------SRASTAMAM------- PLK4_Hsap_SAK -----------------VLQ--------------ISSDGNTITIY--------------- PLK3_Hsap_PLK2 -------------------R--------------N------CIAF--------------- PLK2_Hsap_PLK2 -------------------R--------------G------CLEN--------------- PLK1_Hsap_PLK1 -------------------H--------------S------VNAS--------------- polo_Dmel_PLK1 -------------------T--------------N------LING--------------- SAK_Dmel_SAK -----------------ICR--------------ISDDGQRIIIY--------------- PLK5_Mmus_PLK2 -------------------F--------------L------CLDA--------------- PLK4_Mmus_SAK -----------------VLQ--------------ISSDGTMITVY--------------- PLK3_Mmus_PLK2 -------------------R--------------N------CVAF--------------- PLK2_Mmus_PLK2 -------------------R--------------G------CLEN--------------- PLK1_Mmus_PLK1 -------------------T--------------S------VNAS--------------- plk-2_Cele_PLK1 -------------------N--------------D------LLAT--------------- plk-1_Cele_PLK1 -------------------A--------------V------LLEQ--------------- F55G1.8_Cele_PLK1 -----------------ILQ--------------N------VVAS--------------- CDC5_Scer_PLK1 -----------------TLN--------------G------IVEA--------------- zyg-1_Cele_SAK ------------------------------------------------------------ PLK_Ddis_PLK1 -----------------ANNHISDSPPVS----SN------NNYP--------------- 8635_Tthe_SAK ------------------------------------------------------------ 18358b_Tthe_PLK-Unclassified -----------------NTY--------G----LN------GSVA--------------- 18380_Tthe_PLK-Unclassified -----------------SMQ--------------T------LKHG--------------- 21183_Tthe_SAK NI---------------NTNNFFQS-QK-------------------------------- 22503_Tthe_PLK-Unclassified KY---------------NTIHISDTNQNQ--NHNK------ANNPY-------------- 5034_Tthe_SAK KNNSYSISQSKVIPLPKKVQTSFLQNLNSLTDVDR------FSPPHNNTNSTNTTTNNYV 8829_Tthe_PLK-Unclassified -----------------KTK--------------N------NFNS--------------- SAK_Spur_SAK -----------------VLR--------------ISQDGMQVTIY--------------- PLK1_Spur_PLK1 -------------------T--------------S------VVAA--------------- PLK2_Spur_PLK2 -------------------N--------------T------CLEH--------------- n1170_Tthe_PLK-Unclassified -----------------KTD--------------G------FQNP--------------- n808_Tthe_PLK-Unclassified ------------------------------------------------------------ CC1G_07437_Ccin_PLK1 -------------------T--------------M------AFDA--------------- AqueK200_Aque_PLK1 -------------------S--------------S------CLTS--------------- AqueK201_Aque_SAK ------------------------------------------------------------ GK066_Glam_PLK-Unclassified -------------------Q--------------N------VGSA--------------- PLK4_Hsap_SAK ----------------------------------------------YP----NG------ PLK3_Hsap_PLK2 ----------------------------------------------MPP--A-------- PLK2_Hsap_PLK2 ----------------------------------------------MPE--A-------- PLK1_Hsap_PLK1 ----------------------------------------------KPS--ERGL----- polo_Dmel_PLK1 ----------------------------------------------KPR--ILQG----- SAK_Dmel_SAK ----------------------------------------------QP----DP------ PLK5_Mmus_PLK2 ----------------------------------------------GPM--A-------- PLK4_Mmus_SAK ----------------------------------------------YP----ND------ PLK3_Mmus_PLK2 ----------------------------------------------MPP--A-------- PLK2_Mmus_PLK2 ----------------------------------------------MPE--A-------- PLK1_Mmus_PLK1 ----------------------------------------------KPS--ERGL----- plk-2_Cele_PLK1 ----------------------------------------------PTADIDDAE----- plk-1_Cele_PLK1 ----------------------------------------------RIPGLEEEE----- F55G1.8_Cele_PLK1 ----------------------------------------------KN----KSS----- CDC5_Scer_PLK1 ----------------------------------------------EA----QYK----- zyg-1_Cele_SAK ------------------------------------------------------------ PLK_Ddis_PLK1 ----------------------------------------------QQI--QKQQ----- 8635_Tthe_SAK -NS--------------------------------------------------------- 18358b_Tthe_PLK-Unclassified ----------------------------------------------KE----QCF----- 18380_Tthe_PLK-Unclassified ----------------------------------------------QF----NSD----- 21183_Tthe_SAK -------SYKNP------------------I---------VQI----L----NGFPNDSK 22503_Tthe_PLK-Unclassified --------YNL----------------------------------PAQ----SGQ----- 5034_Tthe_SAK NIQSEINNFPQPQTVSHNRTKNQVSFENKPIQAQVQNQTTQKVMQSSD----QGF----- 8829_Tthe_PLK-Unclassified ----------------------------------------------TQ----KGF----- SAK_Spur_SAK ----------------------------------------------QP----NG------ PLK1_Spur_PLK1 ----------------------------------------------KPS--EKAD----- PLK2_Spur_PLK2 ----------------------------------------------MPK--E--D----- n1170_Tthe_PLK-Unclassified ----------------------------------------------QN----QQQ----- n808_Tthe_PLK-Unclassified ------------------------------------------------------------ CC1G_07437_Ccin_PLK1 ----------------------------------------------RAA--GR-V----- AqueK200_Aque_PLK1 ----------------------------------------------CPS--TKNP----- AqueK201_Aque_SAK ------------------------------------------------------------ GK066_Glam_PLK-Unclassified ----------------------------------------------QGV--V-NK----- PLK4_Hsap_SAK ---------------------GRGF----PLADRPPSPT--DNISRYSFDNLPEKYWRKY PLK3_Hsap_PLK2 ----------------------E-Q----NP----------------------------- PLK2_Hsap_PLK2 ----------------------D-C----IP----------------------------- PLK1_Hsap_PLK1 ---------------------VR-Q----EE----------------------------- polo_Dmel_PLK1 ---------------------NL-G----DE----------------------------- SAK_Dmel_SAK ---------------------GRGL----PVREQPPDLQIPSGDCVYNYDNLPSKHWKKY PLK5_Mmus_PLK2 ----------------------G-Q----DP----------------------------- PLK4_Mmus_SAK ---------------------GRGF----PLADRPPLPT--DNISRYSFDNLPEKYWRKY PLK3_Mmus_PLK2 ----------------------E-Q----NP----------------------------- PLK2_Mmus_PLK2 ----------------------D-C----IP----------------------------- PLK1_Mmus_PLK1 ---------------------VR-Q----EE----------------------------- plk-2_Cele_PLK1 ---------------------AA-L----DS----------------------------- plk-1_Cele_PLK1 ---------------------AA-L----DG----------------------------- F55G1.8_Cele_PLK1 ---------------------T-RF----GL----------------------------- CDC5_Scer_PLK1 ---------------------MGGL----PK----------------------------- zyg-1_Cele_SAK ------------------------------------------------------------ PLK_Ddis_PLK1 ---------------------PNFN----NE----------------------------- 8635_Tthe_SAK ------------------------------------------------------------ 18358b_Tthe_PLK-Unclassified ---------------------QK-S----SS----------------------------- 18380_Tthe_PLK-Unclassified ---------------------LNSE----NI----------------------------- 21183_Tthe_SAK IQQNQAINHQKNKSLDISGIIPPQPPRPRDE----------------------------- 22503_Tthe_PLK-Unclassified ---------------------QNSNQSPLEQ----------------------------- 5034_Tthe_SAK ---------------------YKKNNNPPQS----------------------------- 8829_Tthe_PLK-Unclassified ---------------------MQ-T----GT----------------------------- SAK_Spur_SAK ---------------------GKGF----PIMEHPPSPPQDSGITKHSYHDLPSKYWKKY PLK1_Spur_PLK1 ---------------------IR-L----DE----------------------------- PLK2_Spur_PLK2 ---------------------HR-T----TP----------------------------- n1170_Tthe_PLK-Unclassified ---------------------LNGE----EN----------------------------- n808_Tthe_PLK-Unclassified ------------------------------------------------------------ CC1G_07437_Ccin_PLK1 ---------------------FR-S----PL----------------------------- AqueK200_Aque_PLK1 ---------------------AH-Y----DE----------------------------- AqueK201_Aque_SAK ------------------------------------------------------------ GK066_Glam_PLK-Unclassified ---------------------YG-I----NE----------------------------- PLK4_Hsap_SAK QYASRFVQLVRSKSPKITYFTRYAKCILMENSPGAD------------------------ PLK3_Hsap_PLK2 ------------------------------------------------------------ PLK2_Hsap_PLK2 ------------------------------------------------------------ PLK1_Hsap_PLK1 ------------------------------------------------------------ polo_Dmel_PLK1 ------------------------------------------------------------ SAK_Dmel_SAK IYGARFVGLVKSKTPKVTYFSTLGKCQLMETM--TD------------------------ PLK5_Mmus_PLK2 ------------------------------------------------------------ PLK4_Mmus_SAK QYASRFIQLVRSKTPKITYFTRYAKCILMENSPGAD------------------------ PLK3_Mmus_PLK2 ------------------------------------------------------------ PLK2_Mmus_PLK2 ------------------------------------------------------------ PLK1_Mmus_PLK1 ------------------------------------------------------------ plk-2_Cele_PLK1 ------------------------------------------------------------ plk-1_Cele_PLK1 ------------------------------------------------------------ F55G1.8_Cele_PLK1 ------------------------------------------------------------ CDC5_Scer_PLK1 ------------------------------------------------------------ zyg-1_Cele_SAK ------------------------------------------------------------ PLK_Ddis_PLK1 ------------------------------------------------------------ 8635_Tthe_SAK ------------------------------------------------------------ 18358b_Tthe_PLK-Unclassified ------------------------------------------------------------ 18380_Tthe_PLK-Unclassified ------------------------------------------------------------ 21183_Tthe_SAK ------------------------------------------------------------ 22503_Tthe_PLK-Unclassified ------------------------------------------------------------ 5034_Tthe_SAK ------------------------------------------------------------ 8829_Tthe_PLK-Unclassified ------------------------------------------------------------ SAK_Spur_SAK QYASRFIQLVRSKTPKVTLYTPHAKCMLMENGPTADCEACFYDGTKIHATSVELEVTESN PLK1_Spur_PLK1 ------------------------------------------------------------ PLK2_Spur_PLK2 ------------------------------------------------------------ n1170_Tthe_PLK-Unclassified ------------------------------------------------------------ n808_Tthe_PLK-Unclassified ------------------------------------------------------------ CC1G_07437_Ccin_PLK1 ------------------------------------------------------------ AqueK200_Aque_PLK1 ------------------------------------------------------------ AqueK201_Aque_SAK ------------------------------------------------------------ GK066_Glam_PLK-Unclassified ------------------------------------------------------------ PLK4_Hsap_SAK ------------------------------------------------------------ PLK3_Hsap_PLK2 ------------------------------------------------------------ PLK2_Hsap_PLK2 ------------------------------------------------------------ PLK1_Hsap_PLK1 ------------------------------------------------------------ polo_Dmel_PLK1 ------------------------------------------------------------ SAK_Dmel_SAK ------------------------------------------------------------ PLK5_Mmus_PLK2 ------------------------------------------------------------ PLK4_Mmus_SAK ------------------------------------------------------------ PLK3_Mmus_PLK2 ------------------------------------------------------------ PLK2_Mmus_PLK2 ------------------------------------------------------------ PLK1_Mmus_PLK1 ------------------------------------------------------------ plk-2_Cele_PLK1 ------------------------------------------------------------ plk-1_Cele_PLK1 ------------------------------------------------------------ F55G1.8_Cele_PLK1 ------------------------------------------------------------ CDC5_Scer_PLK1 ------------------------------------------------------------ zyg-1_Cele_SAK ------------------------------------------------------------ PLK_Ddis_PLK1 ------------------------------------------------------------ 8635_Tthe_SAK ------------------------------------------------------------ 18358b_Tthe_PLK-Unclassified ------------------------------------------------------------ 18380_Tthe_PLK-Unclassified ------------------------------------------------------------ 21183_Tthe_SAK ------------------------------------------------------------ 22503_Tthe_PLK-Unclassified ------------------------------------------------------------ 5034_Tthe_SAK ------------------------------------------------------------ 8829_Tthe_PLK-Unclassified ------------------------------------------------------------ SAK_Spur_SAK GQTCKLPADQNNDQIPSHLKPIISSFYTWRQHCVDVESAIASLESRHGYGPFFPLILSRK PLK1_Spur_PLK1 ------------------------------------------------------------ PLK2_Spur_PLK2 ------------------------------------------------------------ n1170_Tthe_PLK-Unclassified ------------------------------------------------------------ n808_Tthe_PLK-Unclassified ------------------------------------------------------------ CC1G_07437_Ccin_PLK1 ------------------------------------------------------------ AqueK200_Aque_PLK1 ------------------------------------------------------------ AqueK201_Aque_SAK ---------------------------GNVTLATN------------------------- GK066_Glam_PLK-Unclassified ------------------------------------------------------------ PLK4_Hsap_SAK ------------------------------------------------------------ PLK3_Hsap_PLK2 ------------------------------------------------------------ PLK2_Hsap_PLK2 ------------------------------------------------------------ PLK1_Hsap_PLK1 ------------------------------------------------------------ polo_Dmel_PLK1 ------------------------------------------------------------ SAK_Dmel_SAK ------------------------------------------------------------ PLK5_Mmus_PLK2 ------------------------------------------------------------ PLK4_Mmus_SAK ------------------------------------------------------------ PLK3_Mmus_PLK2 ------------------------------------------------------------ PLK2_Mmus_PLK2 ------------------------------------------------------------ PLK1_Mmus_PLK1 ------------------------------------------------------------ plk-2_Cele_PLK1 ------------------------------------------------------------ plk-1_Cele_PLK1 ------------------------------------------------------------ F55G1.8_Cele_PLK1 ------------------------------------------------------------ CDC5_Scer_PLK1 ------------------------------------------------------------ zyg-1_Cele_SAK ------------------------------------------------------------ PLK_Ddis_PLK1 ------------------------------------------------------------ 8635_Tthe_SAK ------------------------------------------------------------ 18358b_Tthe_PLK-Unclassified ------------------------------------------------------------ 18380_Tthe_PLK-Unclassified ------------------------------------------------------------ 21183_Tthe_SAK ------------------------------------------------------------ 22503_Tthe_PLK-Unclassified ------------------------------------------------------------ 5034_Tthe_SAK ------------------------------------------------------------ 8829_Tthe_PLK-Unclassified ------------------------------------------------------------ SAK_Spur_SAK PLQESYQQGNKLPASTNIRTSAVTSHTTPATTTTTSTTTVPPSTTPHPSGPTQACPQGSV PLK1_Spur_PLK1 ------------------------------------------------------------ PLK2_Spur_PLK2 ------------------------------------------------------------ n1170_Tthe_PLK-Unclassified ------------------------------------------------------------ n808_Tthe_PLK-Unclassified ------------------------------------------------------------ CC1G_07437_Ccin_PLK1 ------------------------------------------------------------ AqueK200_Aque_PLK1 ------------------------------------------------------------ AqueK201_Aque_SAK ------------------------------------------------------------ GK066_Glam_PLK-Unclassified ------------------------------------------------------------ PLK4_Hsap_SAK ------------------------------------------------------------ PLK3_Hsap_PLK2 ------------------------------------------------------AP---- PLK2_Hsap_PLK2 ------------------------------------------------------KE---- PLK1_Hsap_PLK1 ------------------------------------------------------AE---- polo_Dmel_PLK1 ------------------------------------------------------NT---- SAK_Dmel_SAK ------------------------------------------------------------ PLK5_Mmus_PLK2 ------------------------------------------------------------ PLK4_Mmus_SAK ------------------------------------------------------------ PLK3_Mmus_PLK2 ------------------------------------------------------AP---- PLK2_Mmus_PLK2 ------------------------------------------------------KE---- PLK1_Mmus_PLK1 ------------------------------------------------------AE---- plk-2_Cele_PLK1 ------------------------------------------------------YQ---- plk-1_Cele_PLK1 ------------------------------------------------------YQ---- F55G1.8_Cele_PLK1 ------------------------------------------------------NH---- CDC5_Scer_PLK1 ------------------------------------------------------SR---- zyg-1_Cele_SAK ------------------------------------------------------------ PLK_Ddis_PLK1 ------------------------------------------------------FY---- 8635_Tthe_SAK ------------------------------------------------------------ 18358b_Tthe_PLK-Unclassified ------------------------------------------------------LN---- 18380_Tthe_PLK-Unclassified ------------------------------------------------------LV---- 21183_Tthe_SAK ------------------------------------------------------QKNQLS 22503_Tthe_PLK-Unclassified ------------------------------------------------------IN---- 5034_Tthe_SAK ------------------------------------------------------VQTNLQ 8829_Tthe_PLK-Unclassified ------------------------------------------------------QN---- SAK_Spur_SAK TSPSVMAAPTASVCSFDGTICSVARSVQGKDRTRHRKIDKGGSSKEASKVTSQASS---- PLK1_Spur_PLK1 ------------------------------------------------------AE---- PLK2_Spur_PLK2 ------------------------------------------------------KY---- n1170_Tthe_PLK-Unclassified ------------------------------------------------------NQ---- n808_Tthe_PLK-Unclassified ------------------------------------------------------------ CC1G_07437_Ccin_PLK1 ------------------------------------------------------GD---- AqueK200_Aque_PLK1 ------------------------------------------------------AE---- AqueK201_Aque_SAK ------------------------------------------------------------ GK066_Glam_PLK-Unclassified ------------------------------------------------------AE---- PLK4_Hsap_SAK ------------------------------------------------------------ PLK3_Hsap_PLK2 ---LAQ------------------------------------------------------ PLK2_Hsap_PLK2 ----QL------------------------------------------------------ PLK1_Hsap_PLK1 ---DPA------------------------------------------------------ polo_Dmel_PLK1 ---DPA------------------------------------------------------ SAK_Dmel_SAK ------------------------------------------------------------ PLK5_Mmus_PLK2 ---PGE------------------------------------------------------ PLK4_Mmus_SAK ------------------------------------------------------------ PLK3_Mmus_PLK2 ---LAQ------------------------------------------------------ PLK2_Mmus_PLK2 ----QL------------------------------------------------------ PLK1_Mmus_PLK1 ---DPA------------------------------------------------------ plk-2_Cele_PLK1 ---SPE------------------------------------------------------ plk-1_Cele_PLK1 ---SPE------------------------------------------------------ F55G1.8_Cele_PLK1 ---SPE------------------------------------------------------ CDC5_Scer_PLK1 ---LPK------------------------------------------------------ zyg-1_Cele_SAK ------------------------------------------------------------ PLK_Ddis_PLK1 ---LGM------------------------------------------------------ 8635_Tthe_SAK ------------------------------------------------------------ 18358b_Tthe_PLK-Unclassified ---PQS------------------------------------------------------ 18380_Tthe_PLK-Unclassified ---NTP------------------------------------------------------ 21183_Tthe_SAK ----------------------FKTIDQENI----------------------------- 22503_Tthe_PLK-Unclassified ---LLT------------------------------------------------------ 5034_Tthe_SAK RNQSPQLHVGNKNTSDNLNYYLTKKDHPQCVEDQADKYEEIIHQRKNENKIINRENNIKR 8829_Tthe_PLK-Unclassified ---FGK------------------------------------------------------ SAK_Spur_SAK ---HPE------------------------------------------------------ PLK1_Spur_PLK1 ---DPA------------------------------------------------------ PLK2_Spur_PLK2 ---KPN------------------------------------------------------ n1170_Tthe_PLK-Unclassified ---IDG------------------------------------------------------ n808_Tthe_PLK-Unclassified ------------------------------------------------------------ CC1G_07437_Ccin_PLK1 ---QPL------------------------------------------------------ AqueK200_Aque_PLK1 ---DPA------------------------------------------------------ AqueK201_Aque_SAK ------------------------------------------------------------ GK066_Glam_PLK-Unclassified ---YPQ------------------------------------------------------ PLK4_Hsap_SAK ------------------------------------------------------------ PLK3_Hsap_PLK2 --PEPLV-WV-SKWV----DYSNKFGFG----------YQLSSR---------------- PLK2_Hsap_PLK2 --STSFQ-WV-TKWV----DYSNKYGFG----------YQLSDH---------------- PLK1_Hsap_PLK1 --CIPIF-WV-SKWV----DYSDKYGLG----------YQLCDN---------------- polo_Dmel_PLK1 --AQPLF-WI-SKWV----DYSDKYGFG----------YQLCDE---------------- SAK_Dmel_SAK ------------------------------------------------------------ PLK5_Mmus_PLK2 --QRPVL-WA-PKWV----DYSLKYGFG----------YQLSDG---------------- PLK4_Mmus_SAK ------------------------------------------------------------ PLK3_Mmus_PLK2 --PEPLV-WV-SKWV----DYSNKFGFG----------YQLSSR---------------- PLK2_Mmus_PLK2 --STSFQ-WV-TKWV----DYSNKYGFG----------YQLSDH---------------- PLK1_Mmus_PLK1 --CIPIF-WV-SKWV----DYSDKYGLG----------YQLCDN---------------- plk-2_Cele_PLK1 --ALPVF-WI-SKWV----DYSDKYGIG----------YQLCDN---------------- plk-1_Cele_PLK1 --CLPVF-WI-SKWV----DYSDKYGIG----------YQLCDN---------------- F55G1.8_Cele_PLK1 --ATPIF-WV-SQWV----HFPN-HGIG----------YRLCEN---------------- CDC5_Scer_PLK1 --IKHPM-IV-TKWV----DYSNKHGFS----------YQLSTE---------------- zyg-1_Cele_SAK -------------WP----IRMD-RLEG----------QRVCTA---------------- PLK_Ddis_PLK1 --PNNLV-YI-SQYA----DFTNKYGLA----------YVLSNS---------------- 8635_Tthe_SAK ---------E-KTQQ----DYSNNAFKS----------YRSTSSLHQNISIANTSQTYRN 18358b_Tthe_PLK-Unclassified --EGPDI-WV-SKWV----DYSSKYGLG----------YLLNNG---------------- 18380_Tthe_PLK-Unclassified --PASEI-WV-TQWV----DYSNKYGLG----------YALNNG---------------- 21183_Tthe_SAK -------QKK-QISI----DQSNQNEFVTTPSGNNKMFSQSSNN---------------- 22503_Tthe_PLK-Unclassified --QKQNI-YL-FDYI----DCSSKFGLA----------YYLNNG---------------- 5034_Tthe_SAK ISSEQNISRVSTEYKNGSNDFNTQNKLN----------NQYNNN---------------- 8829_Tthe_PLK-Unclassified --PVQPV-WV-TQWV----DYSAKYGLG----------YLLSNG---------------- SAK_Spur_SAK --G--KD-GV-LKSV-----FVPNIGWA----------SQMSSG---------------- PLK1_Spur_PLK1 --AAPIL-WV-SKWV----DYSDKYGLG----------YQLCDG---------------- PLK2_Spur_PLK2 --PSEVV-WV-IKWV----DYSNKYGFG----------YQLSNK---------------- n1170_Tthe_PLK-Unclassified --SKNNL-WV-VQYV----DYSSKYGLG----------YLLSNQ---------------- n808_Tthe_PLK-Unclassified ------------------------------------------------------------ CC1G_07437_Ccin_PLK1 --PEERV-FI-VSWV----DYCNKYGMG----------HF-------------------- AqueK200_Aque_PLK1 --SMPVF-WI-CKWV----DYTDKYGLG----------YQLCDN---------------- AqueK201_Aque_SAK --------------------YSGPTS-R----------YSTRRG---------------- GK066_Glam_PLK-Unclassified --IDPPC-YI-MSWV----DYSNRYGFA----------YQISNG---------------- PLK4_Hsap_SAK ------------F-EV-------------------------------------------- PLK3_Hsap_PLK2 -----------RV-AV-------------------------------------------- PLK2_Hsap_PLK2 -----------TV-GV-------------------------------------------- PLK1_Hsap_PLK1 -----------SV-GV-------------------------------------------- polo_Dmel_PLK1 -----------GI-GV-------------------------------------------- SAK_Dmel_SAK ------------F-EI-------------------------------------------- PLK5_Mmus_PLK2 -----------GS-GV-------------------------------------------- PLK4_Mmus_SAK ------------F-EV-------------------------------------------- PLK3_Mmus_PLK2 -----------RV-AV-------------------------------------------- PLK2_Mmus_PLK2 -----------TV-GV-------------------------------------------- PLK1_Mmus_PLK1 -----------SV-GV-------------------------------------------- plk-2_Cele_PLK1 -----------SV-GV-------------------------------------------- plk-1_Cele_PLK1 -----------SV-GV-------------------------------------------- F55G1.8_Cele_PLK1 -----------SS-GM-------------------------------------------- CDC5_Scer_PLK1 -----------DI-GV-------------------------------------------- zyg-1_Cele_SAK -----------GG-RY-------------------------------------------- PLK_Ddis_PLK1 -----------YV-GA-------------------------------------------- 8635_Tthe_SAK PLQESQINKNNQQRQEA------------------------------------------- 18358b_Tthe_PLK-Unclassified -----------QA-GV-------------------------------------------- 18380_Tthe_PLK-Unclassified -----------TI-GV-------------------------------------------- 21183_Tthe_SAK -----------MI-FM-------------------------------------------- 22503_Tthe_PLK-Unclassified -----------NV-GI-------------------------------------------- 5034_Tthe_SAK -----------KI-NIDYTSNQLMNNNQQYKINQEYNQNKLSNDFSSNNNKMNNNYVSNK 8829_Tthe_PLK-Unclassified -----------CS-GV-------------------------------------------- SAK_Spur_SAK -----------EV-RV-------------------------------------------- PLK1_Spur_PLK1 -----------SV-GV-------------------------------------------- PLK2_Spur_PLK2 -----------VV-GV-------------------------------------------- n1170_Tthe_PLK-Unclassified -----------SA-GV-------------------------------------------- n808_Tthe_PLK-Unclassified ------------------------------------------------------------ CC1G_07437_Ccin_PLK1 ------------------------------------------------------------ AqueK200_Aque_PLK1 -----------SI-GV-------------------------------------------- AqueK201_Aque_SAK -----------PV-KA-------------------------------------------- GK066_Glam_PLK-Unclassified -----------SI-GV-------------------------------------------- PLK4_Hsap_SAK ---WFYD-----------------------------------------G--VKIH--K-T PLK3_Hsap_PLK2 ---LFND-----------------------------------------G--THMALSA-N PLK2_Hsap_PLK2 ---LFNN-----------------------------------------G--AHMSLLP-D PLK1_Hsap_PLK1 ---LFND-----------------------------------------S--TRLILYN-D polo_Dmel_PLK1 ---MFND-----------------------------------------T--TKLILLP-N SAK_Dmel_SAK ---RFYS-----------------------------------------G--AKLLK-T-P PLK5_Mmus_PLK2 ---LFRD-----------------------------------------G--SHMALRP-Q PLK4_Mmus_SAK ---WFYD-----------------------------------------G--AKIH--K-T PLK3_Mmus_PLK2 ---LFND-----------------------------------------G--THMALSA-N PLK2_Mmus_PLK2 ---LFNN-----------------------------------------G--AHMSLLP-D PLK1_Mmus_PLK1 ---LFND-----------------------------------------S--TRLILYN-D plk-2_Cele_PLK1 ---LFND-----------------------------------------N--SRIMLDT-A plk-1_Cele_PLK1 ---LFND-----------------------------------------N--SRIMLDQ-A F55G1.8_Cele_PLK1 ---LFND-----------------------------------------N--TQMKVNS-A CDC5_Scer_PLK1 ---LFNN-----------------------------------------G--TTVLRLA-D zyg-1_Cele_SAK ---IVEL-----------------------------------------DTRCRFEVAA-Q PLK_Ddis_PLK1 ---YFND-----------------------------------------S--TKIVTLI-E 8635_Tthe_SAK -----FD-----------------------------------------N--TKQALHN-V 18358b_Tthe_PLK-Unclassified ---FFND-----------------------------------------S--TKIILNP-K 18380_Tthe_PLK-Unclassified ---FFND-----------------------------------------F--TKIVIDP-E 21183_Tthe_SAK ---KENN-----------------------------------------N--SKIQNVKK- 22503_Tthe_PLK-Unclassified ---LLND-----------------------------------------G--NVTQIVDET 5034_Tthe_SAK INTEYNT-NKMINHDNPNRMSNEINKSNVDHYSNKNNSDFNKINVDYNS--NKINYDPN- 8829_Tthe_PLK-Unclassified ---FFND-----------------------------------------S--TKVILDP-T SAK_Spur_SAK ---QYND-----------------------------------------G--SMILVHA-A PLK1_Spur_PLK1 ---LFND-----------------------------------------S--TRLLLHA-N PLK2_Spur_PLK2 ---MFND-----------------------------------------K--SRISFTP-D n1170_Tthe_PLK-Unclassified ---VFND-----------------------------------------T--TKIILDP-K n808_Tthe_PLK-Unclassified ------------------------------------------------------------ CC1G_07437_Ccin_PLK1 ------------------------------------------------------------ AqueK200_Aque_PLK1 ---LFND-----------------------------------------F--SKLLLGA-D AqueK201_Aque_SAK ---TFFPSS---------------------------------------G--SHLQED--- GK066_Glam_PLK-Unclassified ---IFND-----------------------------------------E--SAAILSP-N PLK4_Hsap_SAK EDFIQVI-----------------------EKT--------------------------- PLK3_Hsap_PLK2 RKTVHYN-----------------------PTS--------------------------- PLK2_Hsap_PLK2 KKTVHYY-----------------------AEL--------------------------- PLK1_Hsap_PLK1 GDSLQYI-----------------------ERD--------------------------- polo_Dmel_PLK1 QINVHFI-----------------------DKD--------------------------- SAK_Dmel_SAK SEGLKVY-----------------------DRN--------------------------- PLK5_Mmus_PLK2 GGHVSYQ-----------------------PDQ--------------------------- PLK4_Mmus_SAK ENLIHII-----------------------EKT--------------------------- PLK3_Mmus_PLK2 RKTVHYN-----------------------PTS--------------------------- PLK2_Mmus_PLK2 KKTVHYY-----------------------AEL--------------------------- PLK1_Mmus_PLK1 GDSLQYI-----------------------ERD--------------------------- plk-2_Cele_PLK1 GTQLTYI-----------------------EKT--------------------------- plk-1_Cele_PLK1 GNELTYI-----------------------EKS--------------------------- F55G1.8_Cele_PLK1 GNQLTFV-----------------------DEN--------------------------- CDC5_Scer_PLK1 AEEFWYI-----------------------SYD--------------------------- zyg-1_Cele_SAK GNFVKRILIVEVDEMVQTVYVHRIPDRTVRGRN--------------------------- PLK_Ddis_PLK1 SEIAYYM-----------------------EHA--------------------------- 8635_Tthe_SAK KKPLQYF-----------------------SQQQQ------------------------- 18358b_Tthe_PLK-Unclassified TEQFDYI-----------------------ERN--------------------------- 18380_Tthe_PLK-Unclassified GQYIEYY-----------------------EKQ--------------------------- 21183_Tthe_SAK KMSLHFP-----------------------TEQTNISQDIISTNTTCRNNITTTMTFPSP 22503_Tthe_PLK-Unclassified FEHIQKV-----------------------QD---------------------------- 5034_Tthe_SAK KANIDYS-----------------------SN---------------------------- 8829_Tthe_PLK-Unclassified TNNIEYI-----------------------ERL--------------------------- SAK_Spur_SAK TSTIKYM-----------------------DSQ--------------------------- PLK1_Spur_PLK1 ADTLEYI-----------------------ERD--------------------------- PLK2_Spur_PLK2 RSSVQYL-----------------------STD--------------------------- n1170_Tthe_PLK-Unclassified AEYFEYI-----------------------YKK--------------------------- n808_Tthe_PLK-Unclassified ------------------------------------------------------------ CC1G_07437_Ccin_PLK1 ----DYI-----------------------SSR--------------------------- AqueK200_Aque_PLK1 GESMQHI-----------------------SQN--------------------------- AqueK201_Aque_SAK ------------------------------------------------------------ GK066_Glam_PLK-Unclassified ALIVDYS-----------------------PSL--------------------------- PLK4_Hsap_SAK ---------GK------------------------------------------------- PLK3_Hsap_PLK2 ---------TK------------------------------------------------- PLK2_Hsap_PLK2 ---------GQ------------------------------------------------- PLK1_Hsap_PLK1 ---------GT------------------------------------------------- polo_Dmel_PLK1 ---------GK------------------------------------------------- SAK_Dmel_SAK ---------GM------------------------------------------------- PLK5_Mmus_PLK2 ---------GT------------------------------------------------- PLK4_Mmus_SAK ---------GI------------------------------------------------- PLK3_Mmus_PLK2 ---------TK------------------------------------------------- PLK2_Mmus_PLK2 ---------GQ------------------------------------------------- PLK1_Mmus_PLK1 ---------GT------------------------------------------------- plk-2_Cele_PLK1 ---------EK------------------------------------------------- plk-1_Cele_PLK1 ---------NK------------------------------------------------- F55G1.8_Cele_PLK1 ---------NT------------------------------------------------- CDC5_Scer_PLK1 ---------DR------------------------------------------------- zyg-1_Cele_SAK ---------GE------------------------------------------------- PLK_Ddis_PLK1 ---------KG------------------------------------------------- 8635_Tthe_SAK -----TQKD--------------------------------------------------- 18358b_Tthe_PLK-Unclassified ---------SS------------------------------------------------- 18380_Tthe_PLK-Unclassified ---------PE------------------------------------------------- 21183_Tthe_SAK SSQQFLAQNNNNQIIINQNIQRQKPSKSTHNNDNNHTSFDISYLKLDSSQMNSFSVERDF 22503_Tthe_PLK-Unclassified ------------------------------------------------------------ 5034_Tthe_SAK -----------------------------------------------------------N 8829_Tthe_PLK-Unclassified ---------GN------------------------------------------------- SAK_Spur_SAK ---------GK------------------------------------------------- PLK1_Spur_PLK1 ---------GN------------------------------------------------- PLK2_Spur_PLK2 ---------SK------------------------------------------------- n1170_Tthe_PLK-Unclassified ---------DQ------------------------------------------------- n808_Tthe_PLK-Unclassified ------------------------------------------------------------ CC1G_07437_Ccin_PLK1 ---------HH------------------------------------------------- AqueK200_Aque_PLK1 ---------MT------------------------------------------------- AqueK201_Aque_SAK ------------------------------------------------------------ GK066_Glam_PLK-Unclassified ---------LD------------------------------------------------- PLK4_Hsap_SAK ---------------------------SY------------------------------- PLK3_Hsap_PLK2 ---------------------------H-------------------------------- PLK2_Hsap_PLK2 ---------------------------C-------------------------------- PLK1_Hsap_PLK1 ---------------------------E-------------------------------- polo_Dmel_PLK1 ---------------------------E-------------------------------- SAK_Dmel_SAK ---------------------------LL------------------------------- PLK5_Mmus_PLK2 ---------------------------L-------------------------------- PLK4_Mmus_SAK ---------------------------SY------------------------------- PLK3_Mmus_PLK2 ---------------------------H-------------------------------- PLK2_Mmus_PLK2 ---------------------------C-------------------------------- PLK1_Mmus_PLK1 ---------------------------E-------------------------------- plk-2_Cele_PLK1 ---------------------------E-------------------------------- plk-1_Cele_PLK1 ---------------------------E-------------------------------- F55G1.8_Cele_PLK1 ---------------------------EQ------------------------------- CDC5_Scer_PLK1 ---------------------------EG------------------------------- zyg-1_Cele_SAK ---------------------------EE------------------------------- PLK_Ddis_PLK1 --------------------------TDG------------------------------- 8635_Tthe_SAK GDNQMFTQSQNNNTNKQMKGDNTLNGNLKYSSLSTNSQTLNKNDESYIHNYHQPRIRSQQ 18358b_Tthe_PLK-Unclassified ---------------------------SK------------------------------- 18380_Tthe_PLK-Unclassified ---------------------------EK------------------------------- 21183_Tthe_SAK Q------------------------------------STAQFSSKSNV------------ 22503_Tthe_PLK-Unclassified ------------------------------------------------------------ 5034_Tthe_SAK K------------------------------------INIEFNSNNKI------------ 8829_Tthe_PLK-Unclassified ---------------------------ER------------------------------- SAK_Spur_SAK ---------------------------GQ------------------------------- PLK1_Spur_PLK1 ---------------------------E-------------------------------- PLK2_Spur_PLK2 ---------------------------V-------------------------------- n1170_Tthe_PLK-Unclassified ---------------------------DE------------------------------- n808_Tthe_PLK-Unclassified ------------------------------------------------------------ CC1G_07437_Ccin_PLK1 ---------------------------GS------------------------------- AqueK200_Aque_PLK1 ---------------------------E-------------------------------- AqueK201_Aque_SAK ------------------------------------------------------------ GK066_Glam_PLK-Unclassified ---------------------------AA------------------------------- PLK4_Hsap_SAK -------------------T---------------------------------------- PLK3_Hsap_PLK2 ------------------------------------------------------------ PLK2_Hsap_PLK2 ------------------------------------------------------------ PLK1_Hsap_PLK1 ------------------------------------------------------------ polo_Dmel_PLK1 ------------------------------------------------------------ SAK_Dmel_SAK -------------------S---------------------------------------- PLK5_Mmus_PLK2 ------------------------------------------------------------ PLK4_Mmus_SAK -------------------N---------------------------------------- PLK3_Mmus_PLK2 ------------------------------------------------------------ PLK2_Mmus_PLK2 ------------------------------------------------------------ PLK1_Mmus_PLK1 ------------------------------------------------------------ plk-2_Cele_PLK1 ------------------------------------------------------------ plk-1_Cele_PLK1 ------------------------------------------------------------ F55G1.8_Cele_PLK1 ------------------------------------------------------------ CDC5_Scer_PLK1 -------------------W---------------------------------------- zyg-1_Cele_SAK ------------------------------------------------------------ PLK_Ddis_PLK1 -------------------D-------G-------------------------------- 8635_Tthe_SAK SQQNVNLREKSPSCQFIQKNQEISSQNN-------------------------------- 18358b_Tthe_PLK-Unclassified -------------------Q-------D-------------------------------- 18380_Tthe_PLK-Unclassified -------------------Y-------Q-------------------------------- 21183_Tthe_SAK -----IHTPTNVSISQKPPS-------NKNSYTYRDINPPSFAPSQQPTSLMRAKGSSKE 22503_Tthe_PLK-Unclassified -------------------N-------Y-------------------------------- 5034_Tthe_SAK -----N------------------------------------------------------ 8829_Tthe_PLK-Unclassified -------------------Q-------D-------------------------------- SAK_Spur_SAK -------------------R---------------------------------------- PLK1_Spur_PLK1 ------------------------------------------------------------ PLK2_Spur_PLK2 ------------------------------------------------------------ n1170_Tthe_PLK-Unclassified ------------------------------------------------------------ n808_Tthe_PLK-Unclassified ------------------------------------------------------------ CC1G_07437_Ccin_PLK1 -------------------I-------Y-------------------------------- AqueK200_Aque_PLK1 ------------------------------------------------------------ AqueK201_Aque_SAK ------------------------------------------------------------ GK066_Glam_PLK-Unclassified ------------------------------------------------------------ PLK4_Hsap_SAK ------------------------------------------------LKSE-------- PLK3_Hsap_PLK2 ----------------------------------------------FSFSV--------- PLK2_Hsap_PLK2 ----------------------------------------------SVFPA--------- PLK1_Hsap_PLK1 ----------------------------------------------SYLTV--------- polo_Dmel_PLK1 ----------------------------------------------TYMTT--------- SAK_Dmel_SAK ------------------------------------------------DYSC-------- PLK5_Mmus_PLK2 ----------------------------------------------WTFTL--------- PLK4_Mmus_SAK ------------------------------------------------LKNE-------- PLK3_Mmus_PLK2 ----------------------------------------------FSFSM--------- PLK2_Mmus_PLK2 ----------------------------------------------SVFPA--------- PLK1_Mmus_PLK1 ----------------------------------------------SYLTV--------- plk-2_Cele_PLK1 ----------------------------------------------HYFDME-------- plk-1_Cele_PLK1 ----------------------------------------------HYFSMH-------- F55G1.8_Cele_PLK1 -----------------------------------------------FYTMN-------- CDC5_Scer_PLK1 -----------------------------------VA---------SHYLLS-------- zyg-1_Cele_SAK -----------------------------------------------LITLTNNPFVYTS PLK_Ddis_PLK1 -----------------------------------RR---------VLNVT--------- 8635_Tthe_SAK -----------CDGIKDLQNINKIQQNSQ------IK---------RNYSQ--------- 18358b_Tthe_PLK-Unclassified -----------------------------------FG---------AEYTL--------- 18380_Tthe_PLK-Unclassified -----------------------------------KS---------ITFTP--------- 21183_Tthe_SAK YIKTEPCDIDVNQTPR----LECLETENNENTSTAAC---------SKYSM--------- 22503_Tthe_PLK-Unclassified -----------------------------------VI---------QKYPI--------- 5034_Tthe_SAK ------------------------------------------------------------ 8829_Tthe_PLK-Unclassified -----------------------------------FV---------QQFTL--------- SAK_Spur_SAK -----------------------------------AQWKKWIRWRQHCVDVE-------- PLK1_Spur_PLK1 ----------------------------------------------KYCRL--------- PLK2_Spur_PLK2 ----------------------------------------------HSFPL--------- n1170_Tthe_PLK-Unclassified -----------------------------------IT---------EKHSL--------- n808_Tthe_PLK-Unclassified ------------------------------------------------------------ CC1G_07437_Ccin_PLK1 -----------------------------------LR---------KSFTI--------- AqueK200_Aque_PLK1 ----------------------------------------------QFLTL--------- AqueK201_Aque_SAK --------------------------------------------------Q--------- GK066_Glam_PLK-Unclassified -----------------------------------FD---------RAL-FE-------- PLK4_Hsap_SAK --SEVNSLKEEIKMYMDHAN--EGHRIC-------------LA-LESIISEE-ERKTRSA PLK3_Hsap_PLK2 -GAVPRALQPQ-------------------------LGIL-RY-FASYMEQ-HLM----- PLK2_Hsap_PLK2 -TDAPEQFISQ-------------------------VTVL-KY-FSHYMEE-NLM----- PLK1_Hsap_PLK1 -SSHPNSLMKK-------------------------ITLL-KY-FRNYMSE-HLL----- polo_Dmel_PLK1 -TDYCKSLDKK-------------------------MKLL-SY-FKRYMIE-HLV----- SAK_Dmel_SAK --SESRSL-------IEHGN--ECFTHC-------------VN-ISNALEVA---QTKDN PLK5_Mmus_PLK2 -RDVPSPLRAK-------------------------LAVL-RL-FACYMQR-RLR----- PLK4_Mmus_SAK --NEVTSLKEEVKVYMDHAN--EGHRIC-------------LS-LESVISEE-EKRSRGS PLK3_Mmus_PLK2 -GSVPRALQPQ-------------------------LGIL-RY-FASYMEQ-HLM----- PLK2_Mmus_PLK2 -TDAPEQFISQ-------------------------VTVL-KY-FSHYMEE-NLM----- PLK1_Mmus_PLK1 -SSHPNSLMKK-------------------------ITLL-NY-FRNYMSE-HLL----- plk-2_Cele_PLK1 -SAIPSGLQKK-------------------------MTLL-KY-FRSYMND-HLL----- plk-1_Cele_PLK1 SGEMPGLLNKK-------------------------VTLL-KY-FRSYMND-HLV----- F55G1.8_Cele_PLK1 -DQVPMNLQTK-------------------------INIF-SN-VQSYMNT-HLE----- CDC5_Scer_PLK1 --EKPRELSRH-------------------------LEVV-DF-FAKYMKA-NLS----- zyg-1_Cele_SAK YSQMPKEVQND-------------------------YMRLQKM-VAVTISG-RVA----- PLK_Ddis_PLK1 -QQHPHDTQKK-------------------------VTLI-KY-FLNHFTN-SDT----- 8635_Tthe_SAK -QITPKEMQTN-------------------------SNIQ-KLEYANRISQ-LCA----- 18358b_Tthe_PLK-Unclassified -KDYPESLQKK-------------------------LTLL-QH-FRSFLEG-EDK----- 18380_Tthe_PLK-Unclassified -DNYPQELKKK-------------------------VTLL-EH-FRSYLQG-DHG----- 21183_Tthe_SAK -NTTNRSFNKG-------------------------LNTS-KS-FSSFIAD-QTN----- 22503_Tthe_PLK-Unclassified -KQIPPSCQNL-------------------------FRLT-TN-IKEYFLN-KYK----- 5034_Tthe_SAK ----NGYVSNK-------------------------VTSE-VN-KYNYESN-HNK----- 8829_Tthe_PLK-Unclassified -KDYPPEMKKK-------------------------VTLL-SH-FKSYLEE-QMQ----- SAK_Spur_SAK --SAIASLESRHGYGPFFPLILSRKPLQESYQQGNKVTAS-KN-IRTSAATSHTT----- PLK1_Spur_PLK1 -GSYDSTLHKK-------------------------VTLL-KY-FRNYMSE-HLL----- PLK2_Spur_PLK2 -SSVPSRLSKK-------------------------VTLL-DY-FATYMDE-HLI----- n1170_Tthe_PLK-Unclassified -TEYPTDLQKK-------------------------VTLL-QH-FRHYLMT-EVN----- n808_Tthe_PLK-Unclassified ------------------------------------------------------------ CC1G_07437_Ccin_PLK1 -DAYPDELKSK-------------------------VYLL-KH-FEKYIME-RLY----- AqueK200_Aque_PLK1 -SQYPESMHKK-------------------------VTLI-KY-FRDYMSE-HLL----- AqueK201_Aque_SAK --------------------------------SRKATSGL-HH-RRAHSLE-DVC----- GK066_Glam_PLK-Unclassified -EGTTILSEKK-------------------------FKLL-SF-FRDYLEN-RSI----- PLK4_Hsap_SAK PFFPIIIGRKPGST----SSPKALSPPPSVDSNYPTRERASFNRMVMHSA-ASPTQAP-I PLK3_Hsap_PLK2 ------------------------------------------------------------ PLK2_Hsap_PLK2 ------------------------------------------------------------ PLK1_Hsap_PLK1 ------------------------------------------------------------ polo_Dmel_PLK1 ------------------------------------------------------------ SAK_Dmel_SAK SCFPVTIGRRPITD----VQPAQR-LDGL--------------RDTTNIAFSTPKSNQGS PLK5_Mmus_PLK2 ------------------------------------------------------------ PLK4_Mmus_SAK SFFPIIVGRKPGNT----SSPKALSAPP-VDPSCCKGEQASASRLSVNSA-AFPTQSP-G PLK3_Mmus_PLK2 ------------------------------------------------------------ PLK2_Mmus_PLK2 ------------------------------------------------------------ PLK1_Mmus_PLK1 ------------------------------------------------------------ plk-2_Cele_PLK1 ------------------------------------------------------------ plk-1_Cele_PLK1 ------------------------------------------------------------ F55G1.8_Cele_PLK1 ------------------------------------------------------------ CDC5_Scer_PLK1 ------------------------------------------------------------ zyg-1_Cele_SAK ------------------------------------------------------------ PLK_Ddis_PLK1 ------------------------------------------------------------ 8635_Tthe_SAK ------------------------------------------------------------ 18358b_Tthe_PLK-Unclassified ------------------------------------------------------------ 18380_Tthe_PLK-Unclassified ------------------------------------------------------------ 21183_Tthe_SAK ------------------------------------------------------------ 22503_Tthe_PLK-Unclassified ------------------------------------------------------------ 5034_Tthe_SAK ------------------------------------------------------------ 8829_Tthe_PLK-Unclassified ------------------------------------------------------------ SAK_Spur_SAK ---------PATTATSTNTVPPSTT----------PHPGGPTQAC------------P-Q PLK1_Spur_PLK1 ------------------------------------------------------------ PLK2_Spur_PLK2 ------------------------------------------------------------ n1170_Tthe_PLK-Unclassified ------------------------------------------------------------ n808_Tthe_PLK-Unclassified ------------------------------------------------------------ CC1G_07437_Ccin_PLK1 ------------------------------------------------------------ AqueK200_Aque_PLK1 ------------------------------------------------------------ AqueK201_Aque_SAK ------------------------------------------------------------ GK066_Glam_PLK-Unclassified ------------------------------------------------------------ PLK4_Hsap_SAK --L-NPSM----------------------VTNEGLGLTTTAS-----G----------- PLK3_Hsap_PLK2 ------------------------------------------K-----G----------- PLK2_Hsap_PLK2 ------------------------------------------D-----G----------- PLK1_Hsap_PLK1 ------------------------------------------K-----A----------- polo_Dmel_PLK1 ------------------------------------------K-----A----------- SAK_Dmel_SAK --I-NFSL----------------------STISST-RNTSDF-----G----------- PLK5_Mmus_PLK2 ------------------------------------------E-----E----------- PLK4_Mmus_SAK --L-SPST----------------------VTVEGLGHTATAT-----G----------- PLK3_Mmus_PLK2 ------------------------------------------K-----G----------- PLK2_Mmus_PLK2 ------------------------------------------D-----G----------- PLK1_Mmus_PLK1 ------------------------------------------K-----A----------- plk-2_Cele_PLK1 ------------------------------------------Q-----A----------- plk-1_Cele_PLK1 ------------------------------------------K-----A----------- F55G1.8_Cele_PLK1 ------------------------------------------A-----D----------- CDC5_Scer_PLK1 ------------------------------------------R-----V----------- zyg-1_Cele_SAK ------------------------------------------K-----V----------- PLK_Ddis_PLK1 ------------------------------------------TNLLINT----------- 8635_Tthe_SAK ------------------------------------------K-----G----------- 18358b_Tthe_PLK-Unclassified ------------------------------------------K-----A----------- 18380_Tthe_PLK-Unclassified ------------------------------------------S-----N----------- 21183_Tthe_SAK ------------------------------------------E-----I---DKYSNNIQ 22503_Tthe_PLK-Unclassified ------------------------------------------L-----I----------- 5034_Tthe_SAK ------------------------------------------Y-----GNEQNQYKIKYE 8829_Tthe_PLK-Unclassified ------------------------------------------K-----Q----------- SAK_Spur_SAK GSVTSPSVMAAPTASVCSFDGTICSVARSVQGKDRTRHRKTDK-----G----------- PLK1_Spur_PLK1 ------------------------------------------K-----A----------- PLK2_Spur_PLK2 ------------------------------------------K-----G----------- n1170_Tthe_PLK-Unclassified ------------------------------------------K-----K----------- n808_Tthe_PLK-Unclassified ------------------------------------------------------------ CC1G_07437_Ccin_PLK1 ------------------------------------------G-----E----------- AqueK200_Aque_PLK1 ------------------------------------------K-----A----------- AqueK201_Aque_SAK ------------------------------------------------------------ GK066_Glam_PLK-Unclassified ------------------------------------------V-----PI---------- PLK4_Hsap_SAK --T---------------------------------------------D------ISSNS PLK3_Hsap_PLK2 --GD--------------------------------------------L------PSV-- PLK2_Hsap_PLK2 --GD--------------------------------------------L------PSV-- PLK1_Hsap_PLK1 --GA--------------------------------------------N------ITP-- polo_Dmel_PLK1 --GA--------------------------------------------N------NVN-- SAK_Dmel_SAK --T---------------------------------------------N------CSR-- PLK5_Mmus_PLK2 --GT--------------------------------------------V------PMP-- PLK4_Mmus_SAK --T---------------------------------------------G------V---- PLK3_Mmus_PLK2 --GD--------------------------------------------L------PSV-- PLK2_Mmus_PLK2 --GD--------------------------------------------L------PSV-- PLK1_Mmus_PLK1 --GA--------------------------------------------N------ITP-- plk-2_Cele_PLK1 --GQ--------------------------------------------Q------VTR-- plk-1_Cele_PLK1 --GE--------------------------------------------G------SEQ-- F55G1.8_Cele_PLK1 --T---------------------------------------------H------LEAED CDC5_Scer_PLK1 --S---------------------------------------------T------FGREE zyg-1_Cele_SAK --T---------------------------------------------FRRPSQFPDAQA PLK_Ddis_PLK1 --GA--------------------------------------------T------SSSIN 8635_Tthe_SAK --DH--------------------------------------------N------F--L- 18358b_Tthe_PLK-Unclassified --DS--------------------------------------------I------KMPQ- 18380_Tthe_PLK-Unclassified --NQ--------------------------------------------N------ANNNY 21183_Tthe_SAK LNQQ----NS---------------------------------NIITSQ------IS-P- 22503_Tthe_PLK-Unclassified --CP--------------------------------------------K------V--E- 5034_Tthe_SAK FSSP----KMNTEQNTSRLNTDYKGTRLNTDFNNTRDNTECNTQ---------------- 8829_Tthe_PLK-Unclassified --NI--------------------------------------------Q------I--E- SAK_Spur_SAK --GSSKEAC---------------------------------------K------VT-SQ PLK1_Spur_PLK1 --GA--------------------------------------------A------MTP-- PLK2_Spur_PLK2 --ID--------------------------------------------S------DKK-- n1170_Tthe_PLK-Unclassified --VC--------------------------------------------A------ENGST n808_Tthe_PLK-Unclassified -----------------------------------------------------------E CC1G_07437_Ccin_PLK1 --YE---------------------------------------------------YTF-- AqueK200_Aque_PLK1 --GG--------------------------------------------S------VGE-- AqueK201_Aque_SAK -----------------------------------------------------------R GK066_Glam_PLK-Unclassified --PA--------------------------------------------A------DRPKE PLK4_Hsap_SAK ---------L-------------KD--CLP------------------------K----S PLK3_Hsap_PLK2 ----------E---------------------------------E--VE-----V---PA PLK2_Hsap_PLK2 ----------T---------------------------------D--IR---------RP PLK1_Hsap_PLK1 ----------R--------------------------------EG--DE-----L---AR polo_Dmel_PLK1 ----------I--------------------------------ES--DQ-----I---SR SAK_Dmel_SAK -----------------------SN--MLA------------------------A---HQ PLK5_Mmus_PLK2 ----------A---------------------------------T--PA---------SP PLK4_Mmus_SAK -----------------------SS--SLP------------------------K----S PLK3_Mmus_PLK2 ----------E---------------------------------E--AE-----V---PA PLK2_Mmus_PLK2 ----------T---------------------------------D--IR---------RP PLK1_Mmus_PLK1 ----------R--------------------------------EG--DE-----L---AR plk-2_Cele_PLK1 ----------K--------------------------------VG--DD-----L---AR plk-1_Cele_PLK1 ----------R--------------------------------AG--DD-----L---AR F55G1.8_Cele_PLK1 ---------QC------------VN--KVP-------------PL--RN-----F---AR CDC5_Scer_PLK1 ---------Y--------------H--K-------------------------------D zyg-1_Cele_SAK ---------QL------------M-----E-------------NG--DL-----R---IK PLK_Ddis_PLK1 NNNNNNVENVT---------N-NNN--NNS-------------NN--SS-----N---IN 8635_Tthe_SAK --------------------L----------------------EK--KSSSNSNNNCQ-Q 18358b_Tthe_PLK-Unclassified ---------NE---------A----------------------SG--EP-----K---SS 18380_Tthe_PLK-Unclassified D--------VN---------P-PST--FLD-------------NQ--TG-----K---KM 21183_Tthe_SAK --------------------V----------------------KV--GD-----DLDVSK 22503_Tthe_PLK-Unclassified --------------------L----------------------QE--GD-----F---EK 5034_Tthe_SAK -------------------------------------------RLNTEQ-----NT--AR 8829_Tthe_PLK-Unclassified ---------VP---------Q----------------------FQ--GD-----L---QP SAK_Spur_SAK -----------------------AS--SHP------------------------E---GK PLK1_Spur_PLK1 ----------R--------------------------------ES--DS-----M---AR PLK2_Spur_PLK2 ----------D------------------GIRSPSPKRKGVDKPG--PV-----N---SA n1170_Tthe_PLK-Unclassified Q--------AT---------L-YND--SKF-------------QM--QP-----N---QP n808_Tthe_PLK-Unclassified R---------------------KTD--ESN-------------KL--NP----------- CC1G_07437_Ccin_PLK1 ----------E--------------------------------DV--ER-----T---KG AqueK200_Aque_PLK1 ----------R--------------------------------EI--DD-----G---VR AqueK201_Aque_SAK ---------G-------------ND--EI------------------------------- GK066_Glam_PLK-Unclassified ---------DEELKRVIEQERMNNQEIDFKR------------LT--KGL----P---LP PLK4_Hsap_SAK AQL----LKSV----------------------------FVKNVG-WATQLTSGA----- PLK3_Hsap_PLK2 PPL----LLQW----------------------------VKTDQA-LLMLFSDGT----- PLK2_Hsap_PLK2 RLY----LLQW----------------------------LKSDKA-LMMLFNDGT----- PLK1_Hsap_PLK1 LPY----LRTW----------------------------FRTRSA-IILHLSNGS----- polo_Dmel_PLK1 MPH----LHSW----------------------------FRTTCA-VVMHLTNGS----- SAK_Dmel_SAK NIP----IKRI----------------------------NVPEIG-IATELSHGV----- PLK5_Mmus_PLK2 DIS----LLSF----------------------------IADSQA-MVMLFSNGT----- PLK4_Mmus_SAK AQL----LKSV----------------------------FVKNVG-WATQLTSGA----- PLK3_Mmus_PLK2 PPL----LLQW----------------------------VKTDQA-LLMLFSDGT----- PLK2_Mmus_PLK2 RLY----LLQW----------------------------LKSDKA-LMMLFNDGT----- PLK1_Mmus_PLK1 LPY----LRTW----------------------------FRTRSA-IILHLSNGT----- plk-2_Cele_PLK1 LPT----LRVW----------------------------FRTKSA-IVLHLSNGT----- plk-1_Cele_PLK1 LPT----LRVW----------------------------FRTKSA-IVLHLSNGT----- F55G1.8_Cele_PLK1 LPT----IQNW----------------------------FETKSA-VIFHLSNGT----- CDC5_Scer_PLK1 DVF----LRRY----------------------------TRYKPF-VMFELSDGT----- zyg-1_Cele_SAK L----------------------------------------PRSV-IVRKMDNGEIFNCI PLK_Ddis_PLK1 PIY----VKKW----------------------------IKFDNG-IAFRLSDKT----- 8635_Tthe_SAK NVQ----SSKNIRSLSNSQFTINSNIKQKIQKDTSELSIQVTDRQ-ITFQGNEQN----- 18358b_Tthe_PLK-Unclassified KIY----VKKW----------------------------LRTKNA-ILFRLSNKV----- 18380_Tthe_PLK-Unclassified LYY----VKKW----------------------------VKTKNA-ILFRLQNKI----- 21183_Tthe_SAK IKT----KNGY--------IE------------------ITSDHS-LLVESCNGR----- 22503_Tthe_PLK-Unclassified EVY----LKKF----------------------------ISTKQA-SFFRFSNKD----- 5034_Tthe_SAK LTTEQYNPQRV----------------------------ISKNKA-IMFSMDNLQ----- 8829_Tthe_PLK-Unclassified YVY----VKKW----------------------------MKTKHA-IMFRLSNKI----- SAK_Spur_SAK DGV----LKSV----------------------------FVPNIG-WASQMSSGE----- PLK1_Spur_PLK1 LPF----LQSW----------------------------FRTKSA-IVLHLSNGT----- PLK2_Spur_PLK2 QPY----LEKW----------------------------NRTGKA-ITMYLSNGT----- n1170_Tthe_PLK-Unclassified LPY----LKKW----------------------------MQTRHA-IMFRLSNKI----- n808_Tthe_PLK-Unclassified ------------------------------------------------------------ CC1G_07437_Ccin_PLK1 MEW----VQKY----------------------------LRMKHV-IVFKMSHDV----- AqueK200_Aque_PLK1 LPF----LRAW----------------------------SRTRSA-IVFHLSNGT----- AqueK201_Aque_SAK -MK----LSNC----------------------------FSGEQS-VSFSLKDND----- GK066_Glam_PLK-Unclassified QLF----LKKW----------------------------KLYDDGTLCLLFNTKV----- PLK4_Hsap_SAK ------------------------------------------------------------ PLK3_Hsap_PLK2 ------------------------------------------------------------ PLK2_Hsap_PLK2 ------------------------------------------------------------ PLK1_Hsap_PLK1 ------------------------------------------------------------ polo_Dmel_PLK1 ------------------------------------------------------------ SAK_Dmel_SAK ------------------------------------------------------------ PLK5_Mmus_PLK2 ------------------------------------------------------------ PLK4_Mmus_SAK ------------------------------------------------------------ PLK3_Mmus_PLK2 ------------------------------------------------------------ PLK2_Mmus_PLK2 ------------------------------------------------------------ PLK1_Mmus_PLK1 ------------------------------------------------------------ plk-2_Cele_PLK1 ------------------------------------------------------------ plk-1_Cele_PLK1 ------------------------------------------------------------ F55G1.8_Cele_PLK1 ------------------------------------------------------------ CDC5_Scer_PLK1 ------------------------------------------------------------ zyg-1_Cele_SAK DGIATQKQAVSGITLTKVNEVYKYLIRFEQCLNGMDRGMVCFPIVFSAGTNMVGSSPSSL PLK_Ddis_PLK1 ------------------------------------------------------------ 8635_Tthe_SAK ------------------------------------------------------------ 18358b_Tthe_PLK-Unclassified ------------------------------------------------------------ 18380_Tthe_PLK-Unclassified ------------------------------------------------------------ 21183_Tthe_SAK ------------------------------------------------------------ 22503_Tthe_PLK-Unclassified ------------------------------------------------------------ 5034_Tthe_SAK ------------------------------------------------------------ 8829_Tthe_PLK-Unclassified ------------------------------------------------------------ SAK_Spur_SAK ------------------------------------------------------------ PLK1_Spur_PLK1 ------------------------------------------------------------ PLK2_Spur_PLK2 ------------------------------------------------------------ n1170_Tthe_PLK-Unclassified ------------------------------------------------------------ n808_Tthe_PLK-Unclassified ------------------------------------------------------------ CC1G_07437_Ccin_PLK1 ------------------------------------------------------------ AqueK200_Aque_PLK1 ------------------------------------------------------------ AqueK201_Aque_SAK ------------------------------------------------------------ GK066_Glam_PLK-Unclassified ------------------------------------------------------------ PLK4_Hsap_SAK --------------------------------------------VWVQF----------- PLK3_Hsap_PLK2 --------------------------------------------VQVNF----------- PLK2_Hsap_PLK2 --------------------------------------------FQVNF----------- PLK1_Hsap_PLK1 --------------------------------------------VQINF----------- polo_Dmel_PLK1 --------------------------------------------VQLNF----------- SAK_Dmel_SAK --------------------------------------------VQVQF----------- PLK5_Mmus_PLK2 --------------------------------------------VQVSL----------- PLK4_Mmus_SAK --------------------------------------------VWVQF----------- PLK3_Mmus_PLK2 --------------------------------------------VQVNF----------- PLK2_Mmus_PLK2 --------------------------------------------FQVNF----------- PLK1_Mmus_PLK1 --------------------------------------------VQINF----------- plk-2_Cele_PLK1 --------------------------------------------VQINF----------- plk-1_Cele_PLK1 --------------------------------------------VQINF----------- F55G1.8_Cele_PLK1 --------------------------------------------VQINF----------- CDC5_Scer_PLK1 --------------------------------------------FQFNF----------- zyg-1_Cele_SAK MPSGSSQTSRFPFSNLSNNQPSLVPHSAPFLTKPTSSQRASSANVQRRV----------- PLK_Ddis_PLK1 --------------------------------------------IQVNY----------- 8635_Tthe_SAK --------------------------------------------EKINF----------- 18358b_Tthe_PLK-Unclassified --------------------------------------------VQVIF----------- 18380_Tthe_PLK-Unclassified --------------------------------------------VQVSF----------- 21183_Tthe_SAK --------------------------------------------LLFKI----------- 22503_Tthe_PLK-Unclassified --------------------------------------------LQVIF----------- 5034_Tthe_SAK --------------------------------------------GKLNMENANNRISVEQ 8829_Tthe_PLK-Unclassified --------------------------------------------VQVSF----------- SAK_Spur_SAK --------------------------------------------VRVQY----------- PLK1_Spur_PLK1 --------------------------------------------VQINF----------- PLK2_Spur_PLK2 --------------------------------------------LQVNF----------- n1170_Tthe_PLK-Unclassified --------------------------------------------VQVQF----------- n808_Tthe_PLK-Unclassified ------------------------------------------------------------ CC1G_07437_Ccin_PLK1 --------------------------------------------LQFNF----------- AqueK200_Aque_PLK1 --------------------------------------------LQINF----------- AqueK201_Aque_SAK --------------------------------------------VPSSS----------- GK066_Glam_PLK-Unclassified --------------------------------------------FQVNF----------- PLK4_Hsap_SAK -------------------------------N-DG------------------------- PLK3_Hsap_PLK2 ------------------------------YG-DH------------------------- PLK2_Hsap_PLK2 ------------------------------YH-DH------------------------- PLK1_Hsap_PLK1 ------------------------------FQ-DH------------------------- polo_Dmel_PLK1 -------------------------------S-DH------------------------- SAK_Dmel_SAK -------------------------------Y-DG------------------------- PLK5_Mmus_PLK2 ------------------------------KT-SQ------------------------- PLK4_Mmus_SAK -------------------------------N-DG------------------------- PLK3_Mmus_PLK2 ------------------------------YG-DH------------------------- PLK2_Mmus_PLK2 ------------------------------YH-DH------------------------- PLK1_Mmus_PLK1 ------------------------------FQ-DH------------------------- plk-2_Cele_PLK1 ------------------------------FN-DH------------------------- plk-1_Cele_PLK1 ------------------------------FN-DH------------------------- F55G1.8_Cele_PLK1 -------------------------------L-DH------------------------- CDC5_Scer_PLK1 -------------------------------K-DH------------------------- zyg-1_Cele_SAK -------------------------------STDENSSPSVAPSKYKIKIDPTTQKVRSI PLK_Ddis_PLK1 -------------------------------L-DK------------------------- 8635_Tthe_SAK ------------------------------TK-SP------------------------- 18358b_Tthe_PLK-Unclassified -------------------------------Q-DS------------------------- 18380_Tthe_PLK-Unclassified -------------------------------S-DK------------------------- 21183_Tthe_SAK ------------------------------SK-DG------------------------- 22503_Tthe_PLK-Unclassified -------------------------------I-DK------------------------- 5034_Tthe_SAK NINGRFNNEIMKTNNENLILKNGNAQNILNTN-AH------------------------- 8829_Tthe_PLK-Unclassified -------------------------------Q-DK------------------------- SAK_Spur_SAK -------------------------------N-DG------------------------- PLK1_Spur_PLK1 ------------------------------FE-DH------------------------- PLK2_Spur_PLK2 ------------------------------FE-DH------------------------- n1170_Tthe_PLK-Unclassified -------------------------------S-DK------------------------- n808_Tthe_PLK-Unclassified ------------------------------------------------------------ CC1G_07437_Ccin_PLK1 -------------------------------Y-DH------------------------- AqueK200_Aque_PLK1 ------------------------------FQ-DH------------------------- AqueK201_Aque_SAK ------------------------------------------------------------ GK066_Glam_PLK-Unclassified -------------------------------A-DH------------------------- PLK4_Hsap_SAK ----SQLVV-----------------QAGV------------------------------ PLK3_Hsap_PLK2 ----TKLIL-----------------SGWE------------------------------ PLK2_Hsap_PLK2 ----TKIII-----------------CSQN------------------------------ PLK1_Hsap_PLK1 ----TKLIL-----------------CPLM------------------------------ polo_Dmel_PLK1 ----MKLIL-----------------CPRM------------------------------ SAK_Dmel_SAK ----SVVSV-----------------IPSM------------------------------ PLK5_Mmus_PLK2 ----TQLVL-----------------SGED------------------------------ PLK4_Mmus_SAK ----SQLVV-----------------QAGV------------------------------ PLK3_Mmus_PLK2 ----TKLIL-----------------SGWE------------------------------ PLK2_Mmus_PLK2 ----TKIII-----------------CNQS------------------------------ PLK1_Mmus_PLK1 ----TKLIL-----------------CPLM------------------------------ plk-2_Cele_PLK1 ----IKMVL-----------------CPLM------------------------------ plk-1_Cele_PLK1 ----VKMMM-----------------CPLM------------------------------ F55G1.8_Cele_PLK1 ----VKMVL-----------------CPLL------------------------------ CDC5_Scer_PLK1 ----HKMAI-----------------SDGG------------------------------ zyg-1_Cele_SAK QATDGRVLR-----------------CSTS------------------------------ PLK_Ddis_PLK1 ----SRIIV-----------------SSK------------------------------- 8635_Tthe_SAK ----TQIQTRNNSKSFSQSVNCAPIASSKERKVSFVAQSADLQEQIQIIQSKSTQ----- 18358b_Tthe_PLK-Unclassified ----SEIIL-----------------SSEL------------------------------ 18380_Tthe_PLK-Unclassified ----TEIIL-----------------NSIM------------------------------ 21183_Tthe_SAK ----QKIQI-----------------NKLID-KPM------------------------- 22503_Tthe_PLK-Unclassified ----SEVVI-----------------TQQN------------------------------ 5034_Tthe_SAK ----PKIID-----------------KKQKSEVPLI------------------SQIANQ 8829_Tthe_PLK-Unclassified ----TEILL-----------------SSEN------------------------------ SAK_Spur_SAK ----SMILV-----------------HATT------------------------------ PLK1_Spur_PLK1 ----TKLIV-----------------CPMM------------------------------ PLK2_Spur_PLK2 ----TKVIL-----------------SHNN------------------------------ n1170_Tthe_PLK-Unclassified ----TEILL-----------------NSTD------------------------------ n808_Tthe_PLK-Unclassified ------------------------------------------------------------ CC1G_07437_Ccin_PLK1 ----SKLIL-----------------SSNG------------------------------ AqueK200_Aque_PLK1 ----TKIII-----------------CPLM------------------------------ AqueK201_Aque_SAK --------V-----------------YSQ------------------------------- GK066_Glam_PLK-Unclassified ----SKVVV-----------------AH-------------------------------- PLK4_Hsap_SAK -------------------SSI--SYT------SPNG--QT------------------- PLK3_Hsap_PLK2 ------------------PLLV--TFV------ARNR--SA------------------- PLK2_Hsap_PLK2 -----------------EEYLL--TYI------NEDR--IS------------------- PLK1_Hsap_PLK1 -------------------AAV--TYI------DEKR--DF------------------- polo_Dmel_PLK1 -------------------SAI--TYM------DQEK--NF------------------- SAK_Dmel_SAK -----------------QGGGI--TYT------QPNG--TS------------------- PLK5_Mmus_PLK2 -----------------EDLLL--TLQ------EPGGPAVG------------------- PLK4_Mmus_SAK -------------------SSI--SYT------SPDG--QT------------------- PLK3_Mmus_PLK2 ------------------PLLV--TFV------ARNR--SA------------------- PLK2_Mmus_PLK2 -----------------EEYLL--TYI------NEDR--IS------------------- PLK1_Mmus_PLK1 -------------------AAV--TYI------NEKR--DF------------------- plk-2_Cele_PLK1 -------------------QAV--TFI------DENK--RM------------------- plk-1_Cele_PLK1 -------------------QAV--TFI------DQNK--RM------------------- F55G1.8_Cele_PLK1 -----------------K--SV--TFI------EENK--RV------------------- CDC5_Scer_PLK1 -----------------K--LV--TYI------SPSH--ES------------------- zyg-1_Cele_SAK -----------------K--ADQFIFTDPAIRPDDQR--FM------------------- PLK_Ddis_PLK1 -----------------D--MV--TFV------PYRG--QI------------------- 8635_Tthe_SAK ---------------QTG--AV--NFA------DSKT--QY------------------- 18358b_Tthe_PLK-Unclassified -----------------R--AV--TYV------NRKK--QR------------------- 18380_Tthe_PLK-Unclassified -----------------K--IV--TFN------NKQG--IR------------------- 21183_Tthe_SAK ------------------------------------------------------------ 22503_Tthe_PLK-Unclassified -----------------K--NL--YFK------DKNG--TQ------------------- 5034_Tthe_SAK PMRSSQVQLTQQQQQQNI--PI--TFL------NEDR--DLYKKQEKFDKVKHFKNQTSD 8829_Tthe_PLK-Unclassified -----------------K--MV--TYV------DRKG--TR------------------- SAK_Spur_SAK -------------------STI--KYM------DSQG--KG------------------- PLK1_Spur_PLK1 -------------------GAA--TYI------DAKR--NF------------------- PLK2_Spur_PLK2 -----------------NDHLV--TYI------NESR--TP------------------- n1170_Tthe_PLK-Unclassified -----------------K--IV--SFM------NKKG--ER------------------- n808_Tthe_PLK-Unclassified ------------------------------------------------------------ CC1G_07437_Ccin_PLK1 -------------------LLI--THI------DKSY--KM------------------- AqueK200_Aque_PLK1 -------------------QAV--TYI------DEQK--PS------------------- AqueK201_Aque_SAK ------------------RDPV--TCI------SRNS--S-------------------- GK066_Glam_PLK-Unclassified -----------------R--SV--TFM------SEKR--EI------------------- PLK4_Hsap_SAK -------------------------------------------T------RYGENEKLP- PLK3_Hsap_PLK2 -------------------------------------------C------TYLASHLRQL PLK2_Hsap_PLK2 -------------------------------------------T------TFRLTTLLMS PLK1_Hsap_PLK1 -------------------------------------------R------TYRLSLLEEY polo_Dmel_PLK1 -------------------------------------------R------TYRFSTIVEN SAK_Dmel_SAK -------------------------------------------T------HFGKGDDLP- PLK5_Mmus_PLK2 -------------------------------------------V------SYTLDVLRSH PLK4_Mmus_SAK -------------------------------------------T------RYGENEKLP- PLK3_Mmus_PLK2 -------------------------------------------C------TYLASHLRQL PLK2_Mmus_PLK2 -------------------------------------------T------TFRLTTLLMS PLK1_Mmus_PLK1 -------------------------------------------Q------TYRLSLLEEY plk-2_Cele_PLK1 -------------------------------------------F------TYKFSHLAEN plk-1_Cele_PLK1 -------------------------------------------L------TYKLNNLQRN F55G1.8_Cele_PLK1 -------------------------------------------S------TFTFANILTN CDC5_Scer_PLK1 -------------------------------------------T------TYPLVEVLKY zyg-1_Cele_SAK -------------------------------------------R------TDR------- PLK_Ddis_PLK1 -------------------------------------------I------TGTLNYFK-N 8635_Tthe_SAK -------------------------------------------QSNDTNSSFPVSPLS-- 18358b_Tthe_PLK-Unclassified -------------------------------------------E------TFPLSTAMES 18380_Tthe_PLK-Unclassified -------------------------------------------Q------NYPLTPDLKM 21183_Tthe_SAK -----------------------------------------------------EKHYTLN 22503_Tthe_PLK-Unclassified -------------------------------------------K------IHTLNHEDKS 5034_Tthe_SAK NANYSLNNTNNINGSNEYNKEFFNAQYQQQLQDQQEKMMNSKVN------TYRNSQIFES 8829_Tthe_PLK-Unclassified -------------------------------------------T------DYPLSTALES SAK_Spur_SAK -------------------------------------------Q------SYGRNAVLP- PLK1_Spur_PLK1 -------------------------------------------R------TFRLNLIEKH PLK2_Spur_PLK2 -------------------------------------------T------TYRVLHITHH n1170_Tthe_PLK-Unclassified -------------------------------------------F------HYPLADAMNS n808_Tthe_PLK-Unclassified ------------------------------------------------------------ CC1G_07437_Ccin_PLK1 -------------------------------------------T------RWTLEDVMAF AqueK200_Aque_PLK1 -------------------------------------------S------QSDSPSL--- AqueK201_Aque_SAK ---------------------------------------------------------LD- GK066_Glam_PLK-Unclassified -------------------------------------------Y------TYPSEYLKDD PLK4_Hsap_SAK ----------------------DYI----------------------------------- PLK3_Hsap_PLK2 G-------------CS-PDLR-QRL----------------------------------- PLK2_Hsap_PLK2 G-------------CS-SELK-NRM----------------------------------- PLK1_Hsap_PLK1 G-------------CC-KELA-SRL----------------------------------- polo_Dmel_PLK1 G-------------VS-KDLY-QKI----------------------------------- SAK_Dmel_SAK ----------------------FPV----------------------------------- PLK5_Mmus_PLK2 G-------------FT-LAVH-HHL----------------------------------- PLK4_Mmus_SAK ----------------------EYI----------------------------------- PLK3_Mmus_PLK2 G-------------CS-PDLR-QRL----------------------------------- PLK2_Mmus_PLK2 G-------------CS-LELK-NRM----------------------------------- PLK1_Mmus_PLK1 G-------------CC-KELA-SRL----------------------------------- plk-2_Cele_PLK1 G-------------CP-EKFL-HRI----------------------------------- plk-1_Cele_PLK1 G-------------CP-EKFL-HRL----------------------------------- F55G1.8_Cele_PLK1 S-------------CP-KKYL-SRI----------------------------------- CDC5_Scer_PLK1 G-------------EI-PGYPESNF----------------------------------- zyg-1_Cele_SAK -------------------VP-DRA----------------------------------- PLK_Ddis_PLK1 --------------GD-KKIS-EKI----------------------------------- 8635_Tthe_SAK ------------------------------------------------------------ 18358b_Tthe_PLK-Unclassified --------------QN-KEMS-KRL----------------------------------- 18380_Tthe_PLK-Unclassified --------------YS-PEME-KRL----------------------------------- 21183_Tthe_SAK N-------------LP-AKYY-ALY----------------------------------- 22503_Tthe_PLK-Unclassified S-------------LP-HNIR-KRI----------------------------------- 5034_Tthe_SAK Q-------------VG-TQRV-QAVKSKSRIQSGLKTDVSDSETNSISNQNSTTNNLEYY 8829_Tthe_PLK-Unclassified --------------SN-TEMS-KRL----------------------------------- SAK_Spur_SAK ----------------------SHI----------------------------------- PLK1_Spur_PLK1 G-------------CT-PDLY-DRI----------------------------------- PLK2_Spur_PLK2 G-------------CT-KALH-TRL----------------------------------- n1170_Tthe_PLK-Unclassified --------------TN-QDMT-KRL----------------------------------- n808_Tthe_PLK-Unclassified ------------------------------------------------------------ CC1G_07437_Ccin_PLK1 SLHPPQGASGDEIKFN-QRMV-DKL----------------------------------- AqueK200_Aque_PLK1 ------------------------------------------------------------ AqueK201_Aque_SAK ----------------------SSV----------------------------------- GK066_Glam_PLK-Unclassified R-------------FSFKELR-RRV----------------------------------- PLK4_Hsap_SAK ------------------------------------------------------------ PLK3_Hsap_PLK2 ------------------------------------------------------------ PLK2_Hsap_PLK2 ------------------------------------------------------------ PLK1_Hsap_PLK1 ------------------------------------------------------------ polo_Dmel_PLK1 ------------------------------------------------------------ SAK_Dmel_SAK ------------------------------------------------------------ PLK5_Mmus_PLK2 ------------------------------------------------------------ PLK4_Mmus_SAK ------------------------------------------------------------ PLK3_Mmus_PLK2 ------------------------------------------------------------ PLK2_Mmus_PLK2 ------------------------------------------------------------ PLK1_Mmus_PLK1 ------------------------------------------------------------ plk-2_Cele_PLK1 ------------------------------------------------------------ plk-1_Cele_PLK1 ------------------------------------------------------------ F55G1.8_Cele_PLK1 ------------------------------------------------------------ CDC5_Scer_PLK1 ------------------------------------------------------------ zyg-1_Cele_SAK ------------------------------------------------------------ PLK_Ddis_PLK1 ------------------------------------------------------------ 8635_Tthe_SAK -----------------------------------------------------TQGLKAN 18358b_Tthe_PLK-Unclassified ------------------------------------------------------------ 18380_Tthe_PLK-Unclassified ------------------------------------------------------------ 21183_Tthe_SAK ------------------------------------------------------------ 22503_Tthe_PLK-Unclassified ------------------------------------------------------------ 5034_Tthe_SAK ESPRINTLNLMLSPERRIPTTNNSTAVKNNSQMKNLLSGNKDNSSCKNNSNNTSRKNTSK 8829_Tthe_PLK-Unclassified ------------------------------------------------------------ SAK_Spur_SAK ------------------------------------------------------------ PLK1_Spur_PLK1 ------------------------------------------------------------ PLK2_Spur_PLK2 ------------------------------------------------------------ n1170_Tthe_PLK-Unclassified ------------------------------------------------------------ n808_Tthe_PLK-Unclassified ------------------------------------------------------------ CC1G_07437_Ccin_PLK1 ------------------------------------------------------------ AqueK200_Aque_PLK1 ------------------------------------------------------------ AqueK201_Aque_SAK ------------------------------------------------------------ GK066_Glam_PLK-Unclassified ------------------------------------------------------------ PLK4_Hsap_SAK --------------------------------KQKLQCL--------------------- PLK3_Hsap_PLK2 --------------------------------RYALRLL--------------------- PLK2_Hsap_PLK2 --------------------------------EYALNML--------------------- PLK1_Hsap_PLK1 --------------------------------RYARTMV--------------------- polo_Dmel_PLK1 --------------------------------RYAQEKL--------------------- SAK_Dmel_SAK --------------------------------RDRVGQI--------------------- PLK5_Mmus_PLK2 --------------------------------RHGLHL---------------------- PLK4_Mmus_SAK --------------------------------KQKLQCL--------------------- PLK3_Mmus_PLK2 --------------------------------RYALRLL--------------------- PLK2_Mmus_PLK2 --------------------------------EYALNML--------------------- PLK1_Mmus_PLK1 --------------------------------RYARTMV--------------------- plk-2_Cele_PLK1 --------------------------------QYAKCMI--------------------- plk-1_Cele_PLK1 --------------------------------KYAKTMI--------------------- F55G1.8_Cele_PLK1 --------------------------------EYAQAKI--------------------- CDC5_Scer_PLK1 --------------------------------REKLTLI--------------------- zyg-1_Cele_SAK ------------------------------------------------------------ PLK_Ddis_PLK1 --------------------------------KYIYGTL--------------------- 8635_Tthe_SAK K------------------------------------------VNTKNGIIEISENNWLS 18358b_Tthe_PLK-Unclassified --------------------------------TYTKDIL--------------------- 18380_Tthe_PLK-Unclassified --------------------------------KYTKQIL--------------------- 21183_Tthe_SAK --------------------------------GYAKQVI--------------------- 22503_Tthe_PLK-Unclassified --------------------------------LYIKDVF--------------------- 5034_Tthe_SAK QNNNLKWNDRNNRRKRIHSSVNLKKHNDGDFSRWQRCHVDKVRRAFKQKTLQ-------- 8829_Tthe_PLK-Unclassified --------------------------------KYTKDIL--------------------- SAK_Spur_SAK --------------------------------REKLLHM--------------------- PLK1_Spur_PLK1 --------------------------------KYANNMV--------------------- PLK2_Spur_PLK2 --------------------------------SYARHVL--------------------- n1170_Tthe_PLK-Unclassified --------------------------------RYTKEIL--------------------- n808_Tthe_PLK-Unclassified ------------------------------------------------------------ CC1G_07437_Ccin_PLK1 --------------------------------KYCKEVL--------------------- AqueK200_Aque_PLK1 ------------------------------------------------------------ AqueK201_Aque_SAK --------------------------------SERR------------------------ GK066_Glam_PLK-Unclassified --------------------------------DRARKYY--------------------- PLK4_Hsap_SAK ---------------------SSI------------------------------------ PLK3_Hsap_PLK2 ---------------------R-------------------------------------- PLK2_Hsap_PLK2 ---------------------L-------------------------------------- PLK1_Hsap_PLK1 ---------------------DKL---LS----SRS------------------------ polo_Dmel_PLK1 ---------------------RKM---L-------------------------------- SAK_Dmel_SAK ---------------------PNIQLKLKTAPLLGS------------GRKTD------- PLK5_Mmus_PLK2 ------------------------------------------------------------ PLK4_Mmus_SAK ---------------------SSI------------------------------------ PLK3_Mmus_PLK2 ---------------------R-------------------------------------- PLK2_Mmus_PLK2 ---------------------L-------------------------------------- PLK1_Mmus_PLK1 ---------------------DKL---LS----SRS------------------------ plk-2_Cele_PLK1 ---------------------QRL---VE----EHT------------KEETK-H----- plk-1_Cele_PLK1 ---------------------ERL---MS----DAN------------VVSQNPA----- F55G1.8_Cele_PLK1 ---------------------KLL---RP----TNN------------QEHVV------- CDC5_Scer_PLK1 ---------------------KEG---LK------------------------------- zyg-1_Cele_SAK ------------------------------------------------------------ PLK_Ddis_PLK1 ---------------------SNN---LY----SKK------------PESSF-Q----- 8635_Tthe_SAK IECQNGQLIFKISPNGEQVVCQTL---KS----KTP------------L-VKIQNEKGTF 18358b_Tthe_PLK-Unclassified ---------------------THM------------------------------------ 18380_Tthe_PLK-Unclassified ---------------------TDI---LK----QSQ------------PSQNNIN----- 21183_Tthe_SAK ---------------------NAL---KT----KKV------------I-SKLENKEGIF 22503_Tthe_PLK-Unclassified ---------------------LSG---NH----SKT------------QQANKLQGTDNQ 5034_Tthe_SAK ---------------------KNA---QD----KSA------------K-VKLENEDGQF 8829_Tthe_PLK-Unclassified ---------------------THM---LN----NNT------------TNNNN-G----- SAK_Spur_SAK ---------------------PHI------------------------------------ PLK1_Spur_PLK1 ---------------------KNM---LD----KKT------------T----------- PLK2_Spur_PLK2 ---------------------YSM---MG----KGE------------------------ n1170_Tthe_PLK-Unclassified ---------------------THL---LK----NNQ------------RQNTNDE----- n808_Tthe_PLK-Unclassified ------------------------------------------------------------ CC1G_07437_Ccin_PLK1 ---------------------VSI---RS----ATS------------AGAGSGG----- AqueK200_Aque_PLK1 ------------------------------------------------------------ AqueK201_Aque_SAK ------------------------------------------------------------ GK066_Glam_PLK-Unclassified ---------------------EII---KA----ARPVDSLAQYRYNKDS----------- PLK4_Hsap_SAK ------------------------------------------------------------ PLK3_Hsap_PLK2 ------------------------------------------------------------ PLK2_Hsap_PLK2 ------------------------------------------------------------ PLK1_Hsap_PLK1 ------------------------------------------------------------ polo_Dmel_PLK1 ------------------------------------------------------------ SAK_Dmel_SAK --------------------------Y----N---------------------------- PLK5_Mmus_PLK2 ------------------------------------------------------------ PLK4_Mmus_SAK ------------------------------------------------------------ PLK3_Mmus_PLK2 ------------------------------------------------------------ PLK2_Mmus_PLK2 ------------------------------------------------------------ PLK1_Mmus_PLK1 ------------------------------------------------------------ plk-2_Cele_PLK1 ----NA-------------------PA---ANAVRLP----------------------- plk-1_Cele_PLK1 ----RQ-------------------PDMPRSMAAARS----------------------- F55G1.8_Cele_PLK1 --------------------------Y---VD---------------------------- CDC5_Scer_PLK1 ------------------------------------------------------------ zyg-1_Cele_SAK ------------------------------------------------------------ PLK_Ddis_PLK1 ----QLPQQQYQQPQHYQQQTQQPQPQ---PQ---------------------------- 8635_Tthe_SAK MLMSNQPKQ------------------------------------N-----------YEV 18358b_Tthe_PLK-Unclassified ------------------------------------------------------------ 18380_Tthe_PLK-Unclassified ----NN-------------------PQ---NN---------------------------- 21183_Tthe_SAK ILLEN---N------------------------------------C-----------FEA 22503_Tthe_PLK-Unclassified QNSGQ---N----PTKYSS--TT--PS---SNNQVQPSSV----PCSPPISSLTHSSS-- 5034_Tthe_SAK YLYEN---K------------------------------------------------FEG 8829_Tthe_PLK-Unclassified ----RG------------------------------------------------------ SAK_Spur_SAK ------------------------------------------------------------ PLK1_Spur_PLK1 ------------------------------------------------------------ PLK2_Spur_PLK2 ------------------------------------------------------------ n1170_Tthe_PLK-Unclassified ----QG------------------NNA---ANSVAPPDDMPQNEPN-------------- n808_Tthe_PLK-Unclassified ------------------------------------------------------------ CC1G_07437_Ccin_PLK1 ----GG------------------GG-E------RGTS---------------------- AqueK200_Aque_PLK1 ------------------------------------------------------------ AqueK201_Aque_SAK ------------------------------------------------------------ GK066_Glam_PLK-Unclassified ------------------------------------------------------------ PLK4_Hsap_SAK ------------------------------------------------------------ PLK3_Hsap_PLK2 ------------------------------------------------------------ PLK2_Hsap_PLK2 ------------------------------------------------------------ PLK1_Hsap_PLK1 ------------------------------------------------------------ polo_Dmel_PLK1 ------------------------------------------------------------ SAK_Dmel_SAK ------------------------------------------------------------ PLK5_Mmus_PLK2 ------------------------------------------------------------ PLK4_Mmus_SAK ------------------------------------------------------------ PLK3_Mmus_PLK2 ------------------------------------------------------------ PLK2_Mmus_PLK2 ------------------------------------------------------------ PLK1_Mmus_PLK1 ------------------------------------------------------------ plk-2_Cele_PLK1 ------------------------------------------------------------ plk-1_Cele_PLK1 ------------------------------------------------------------ F55G1.8_Cele_PLK1 ------------------------------------------------------------ CDC5_Scer_PLK1 ------------------------------------------------------------ zyg-1_Cele_SAK ------------------------------------------------------------ PLK_Ddis_PLK1 ------------------------------------------------------------ 8635_Tthe_SAK SLSNGYKVSHVIGTDI-------MTVK--------------------------------- 18358b_Tthe_PLK-Unclassified ------------------------------------------------------------ 18380_Tthe_PLK-Unclassified ------------------------------------------------------------ 21183_Tthe_SAK QFKTGYKIYYKNKNAS-------MKIK--------------------------------- 22503_Tthe_PLK-Unclassified --------------QNQKLTQAANNIVNPAQQMSASSLTQYQSVPLQNGQNQASMFNSTY 5034_Tthe_SAK VFSNGFIVNYKLNSQN-------LEIQ--------------------------------- 8829_Tthe_PLK-Unclassified ------------------------------------------------------------ SAK_Spur_SAK ------------------------------------------------------------ PLK1_Spur_PLK1 ------------------------------------------------------------ PLK2_Spur_PLK2 ------------------------------------------------------------ n1170_Tthe_PLK-Unclassified -----------------------------------------------------------Y n808_Tthe_PLK-Unclassified ------------------------------------------------------------ CC1G_07437_Ccin_PLK1 -------TE--------------RGEKERGGERAERG----------------------- AqueK200_Aque_PLK1 ------------------------------------------------------------ AqueK201_Aque_SAK ------------------------------------------------------------ GK066_Glam_PLK-Unclassified ------------------------------------------------------------ PLK4_Hsap_SAK ------------------------------------------------------------ PLK3_Hsap_PLK2 ------------------------------------------------------------ PLK2_Hsap_PLK2 ------------------------------------------------------------ PLK1_Hsap_PLK1 ------------------------------------------------------------ polo_Dmel_PLK1 ------------------------------------------------------------ SAK_Dmel_SAK ------------------------------------------------------------ PLK5_Mmus_PLK2 ------------------------------------------------------------ PLK4_Mmus_SAK ------------------------------------------------------------ PLK3_Mmus_PLK2 ------------------------------------------------------------ PLK2_Mmus_PLK2 ------------------------------------------------------------ PLK1_Mmus_PLK1 ------------------------------------------------------------ plk-2_Cele_PLK1 ------------------------------------------------------------ plk-1_Cele_PLK1 ------------------------------------------------------------ F55G1.8_Cele_PLK1 ------------------------------------------------------------ CDC5_Scer_PLK1 ------------------------------------------------------------ zyg-1_Cele_SAK ------------------------------------------------------------ PLK_Ddis_PLK1 ------------------------------------------------------------ 8635_Tthe_SAK ------------------------------------------------------------ 18358b_Tthe_PLK-Unclassified ------------------------------------------------------------ 18380_Tthe_PLK-Unclassified ------------------------------------------------------------ 21183_Tthe_SAK ------------------------------------------------------------ 22503_Tthe_PLK-Unclassified ----------QQGF------------------------------NQNNPQSSSLSPLNSI 5034_Tthe_SAK ------------------------------------------------------------ 8829_Tthe_PLK-Unclassified ------------------------------------------------------------ SAK_Spur_SAK ------------------------------------------------------------ PLK1_Spur_PLK1 ------------------------------------------------------------ PLK2_Spur_PLK2 ------------------------------------------------------------ n1170_Tthe_PLK-Unclassified NKYGMTATMENEQFPKLNEQKLKGMTSQKSLTEKDQLIYNMTGFNN-------------- n808_Tthe_PLK-Unclassified ------------------------------------------------------------ CC1G_07437_Ccin_PLK1 ------------------ERRMGG---------DDE------------------------ AqueK200_Aque_PLK1 ------------------------------------------------------------ AqueK201_Aque_SAK ------------------------------------------------------------ GK066_Glam_PLK-Unclassified ------------------------------------------------------------ PLK4_Hsap_SAK ------------------------------------------------------------ PLK3_Hsap_PLK2 ------------------------------------------------------------ PLK2_Hsap_PLK2 ------------------------------------------------------------ PLK1_Hsap_PLK1 ------------------------------------------------------------ polo_Dmel_PLK1 ------------------------------------------------------------ SAK_Dmel_SAK ---------------------------------------------NAM------------ PLK5_Mmus_PLK2 ------------------------------------------------------------ PLK4_Mmus_SAK ------------------------------------------------------------ PLK3_Mmus_PLK2 ------------------------------------------------------------ PLK2_Mmus_PLK2 ------------------------------------------------------------ PLK1_Mmus_PLK1 ------------------------------------------------------------ plk-2_Cele_PLK1 ----------------------------------STSSN--------------------- plk-1_Cele_PLK1 ----------------------------------ASAGS--------------------- F55G1.8_Cele_PLK1 ---------------------------------------------SPC------------ CDC5_Scer_PLK1 ------------------------------------------------------------ zyg-1_Cele_SAK ------------------------------------------------------------ PLK_Ddis_PLK1 ---------------------------------------------QQQL----------- 8635_Tthe_SAK ---------------------DKQN-----------------------------KEFIVY 18358b_Tthe_PLK-Unclassified ------------------------------------------------------------ 18380_Tthe_PLK-Unclassified ---------------------------------------------TQRQPM--------- 21183_Tthe_SAK ---------------------APDNNIY-------------------------------E 22503_Tthe_PLK-Unclassified NQNISPVQQDPNNNISNNLQNNIQFSQIMKTNNNTTSSTNNSVSTSQQTPQQQVLNQIKY 5034_Tthe_SAK ---------------------TNKYAPKI------------------------------V 8829_Tthe_PLK-Unclassified ------------------------------------------------------------ SAK_Spur_SAK ------------------------------------------------------------ PLK1_Spur_PLK1 ------------------------------------------------------------ PLK2_Spur_PLK2 ------------------------------------------------------------ n1170_Tthe_PLK-Unclassified ---------------------------------------------GSK------------ n808_Tthe_PLK-Unclassified ------------------------------------------------------------ CC1G_07437_Ccin_PLK1 ------------------------------RERD-----------R--ER---------- AqueK200_Aque_PLK1 ------------------------------------------------------------ AqueK201_Aque_SAK ------------------------------------------------------------ GK066_Glam_PLK-Unclassified ------------------------------------------------------------ PLK4_Hsap_SAK ---------------------------------------LL---MFSNPTPNFH PLK3_Hsap_PLK2 -------------------------------------------------DRSPA PLK2_Hsap_PLK2 --------------------------------------------------QRCN PLK1_Hsap_PLK1 ----------------------------------------------ASNRLKAS polo_Dmel_PLK1 -------------------------------------------------EKMFT SAK_Dmel_SAK ---------------------------------------TPKT-TTPYYNRMLL PLK5_Mmus_PLK2 --------------------------------------------------LQSV PLK4_Mmus_SAK ---------------------------------------LL---MFSNPTPNFQ PLK3_Mmus_PLK2 -------------------------------------------------DQSPA PLK2_Mmus_PLK2 --------------------------------------------------QRCN PLK1_Mmus_PLK1 ----------------------------------------------ASNRLKAS plk-2_Cele_PLK1 ------------------------------VR-LESAA---DI-QPAYPSSSRR plk-1_Cele_PLK1 ------------------------------RGPNQAASHLPQS-ASGSNIHPRR F55G1.8_Cele_PLK1 ---------------RPTT-----------------SN-TAHG-APLASSRYLA CDC5_Scer_PLK1 ---------------------------------------------QKSTIVTVD zyg-1_Cele_SAK ------------------------------------SE-MLHT-LCERMRKLHQ PLK_Ddis_PLK1 ----------------PQQLPQPQQSPAKQHQ--YQPNQIQYQQSIPQPQLINQ 8635_Tthe_SAK LSQQNLNKS------IPQEITLAVKVSLEQ-----MSSCLQK-Q-NEQYLANFK 18358b_Tthe_PLK-Unclassified --------------------------------------------------LSGN 18380_Tthe_PLK-Unclassified ---------------QPSSLSNQNNQNINT-----NG--ELLN-NSQKQNFVLK 21183_Tthe_SAK ISLEKNSKD------FPQEVKNITS---KS-----LKY-YEYLL-NQNKEFQNI 22503_Tthe_PLK-Unclassified NNSQQLSQTAKLSLYQSQKLRVSVENYQSP-----VSKPVQNAP-SVYPLKMYQ 5034_Tthe_SAK FDLQKDLKH------ASKEMK-------TI-----VQK-TQKII--SIITSMKS 8829_Tthe_PLK-Unclassified --------------------------SMTN-----VN----PT-QNGTEKENYN SAK_Spur_SAK ---------------------------------------IQ---LF-VNQNKPT PLK1_Spur_PLK1 --------------------------------------------TTTAAAVPAH PLK2_Spur_PLK2 ------------------------------------------------EDNEKL n1170_Tthe_PLK-Unclassified ---------------TPSQ---QKNPSVTA-----YPNAQQQP-AQLADKNQKK n808_Tthe_PLK-Unclassified -------------------------------------KSKVQ--SVKFKQNKKL CC1G_07437_Ccin_PLK1 ---------ERA----DRGVERERLGSG--REAGS--S-TATL-NRRTSKLSMR AqueK200_Aque_PLK1 --------------------------------------------LIVLSVAVSV AqueK201_Aque_SAK -----------------------------------------TT-ANSTMVSKCI GK066_Glam_PLK-Unclassified -----------------------------------TKKSASGS-STRQLGQGGE