CLUSTAL W (1.83) multiple sequence alignment RAF1_Hsap_RAF MEHI-QGAWKTI--SNG-FGFK----------------D-AVFD--------------GS KSR2_Hsap_KSR MDEE-NMTKSEEQQ-----------------------------------------P---- KSR1_Hsap_KSR MDRA-ALRAAAMGEKKEGGGGG----------------DAAAA------EGGA--G---- phl_Dmel_RAF MSSE-SSTEGDS--D--------------------------------------------- ksr_Dmel_KSR MSSN-NNAPASAPD--T--GST------------------NA---------ND--P---- KSR2_Mmus_KSR MDEE-NMTKSEEQQ-----------------------------------------P---- KSR1_Mmus_KSR MDRA-ALRAAAMGEKKEGGGGG------------------AAA------DGGA--G---- BRAF_Mmus_RAF MAAL-SGGGGSS--SGG-GGGGGGGGGGGDGGGGAEQGQ-ALFNGDMEPEAGA--GAAAS ARAF_Mmus_RAF MEPP-RGPPVSG--A--------------------------------------------- lin-45_Cele_RAF MSRI-NFKKSSA--STT-PT--------------------------------------SP ksr-2_Cele_RAF MSDE-KKKKRGFFR-----------------------------------------Y---- ksr-1_Cele_KSR MMQT-QVASRAGY-SNL-PQF------------------------------GA--G---- BRAF_Hsap_RAF MAAL-SGGGGGG--AE--------------------PGQ-ALFNGDMEPEAGAGAGAAAS ARAF_Hsap_RAF MEPP-RGPPANG--A--------------------------------------------- RAF1_Mmus_RAF MEHI-QGAWKTI--SNG-FGLK----------------D-AVFD--------------GS KSR1_Spur_KSR LLME-KVQ---------------------------------------------------- Raf_Spur_RAF MGDR-TKT---------------------------------------------------- KSR2_Spur_KSR MQPK-EHIALIM------------------------------------------------ AqueK675_Aque_KSR MSTR-RDILSL-L----------------------------------------------- AqueK676_Aque_KSR MSAT-TATAVYS--SSI--GQ------------------------------TQ--D-DKK AqueK677_Aque_RAF MESA-QFLE--------------------------------------------------- AqueK678_Aque_RAF DYFIPSAST--------------------------------------------------- AqueK679_Aque_RAF MATD-SATEDGE------------------------------------------------ RAF1_Hsap_RAF SCISPTI---------------------VQQF---------------------------- KSR2_Hsap_KSR LSLQKAL-QQCELVQNMIDLSISNLEGLRTKCA-----TSNDLT---QKEIRTLESKLVK KSR1_Hsap_KSR AAASRAL-QQCGQLQKLIDISIGSLRGLRTKCA-----VSNDLT---QQEIRTLEAKLVR phl_Dmel_RAF -LYDP-LAEELHNVQLVKHVTRENIDALNAKF---------------------------- ksr_Dmel_KSR ISGSLSVDSNLVIIQDMIDLSANHLEGLRTQCA-----ISSTLT---QQEIRCLESKLVR KSR2_Mmus_KSR LSLQKAL-QQCELVQNMIDLSISNLEGLRTKCA-----ASNDLT---QKEIRTLESKLVK KSR1_Mmus_KSR AAVSRAL-QQCGQLQKLIDISIGSLRGLRTKCS-----VSNDLT---QQEIRTLEAKLVK BRAF_Mmus_RAF SAADPAIPEEVWNIKQMIKLTQEHIEALLDKF---------------------------- ARAF_Mmus_RAF ------------------------------------------------------------ lin-45_Cele_RAF HCPSPRL----------------------------------------------------- ksr-2_Cele_RAF SVL--------------------------------------------------------- ksr-1_Cele_KSR ------------IAQDIKTQAINNLKECLKLTT-----INRFLTSSYEEDAKSVERKIFS BRAF_Hsap_RAF SAADPAIPEEVWNIKQMIKLTQEHIEALLDKF---------------------------- ARAF_Hsap_RAF ------------------------------------------------------------ RAF1_Mmus_RAF SCISPTI---------------------VQQF---------------------------- KSR1_Spur_KSR ------------NLSHLI------------------------------------------ Raf_Spur_RAF --------EQLNVIHMHMELKKKNIEELMERF---------------------------- KSR2_Spur_KSR ------------------------------------------------------------ AqueK675_Aque_KSR ------------------------------------------------------------ AqueK676_Aque_KSR DLFSVT-KGKMKVQQRMIDLTARELESTRVSSQSIPSDGSSDAL---KENIVLVENKLMK AqueK677_Aque_RAF ----------VQAIRQVIRSTRTTLDEFQRSF---------------------------- AqueK678_Aque_RAF ----------LHATEIANHITEINLEKSETKY---------------------------- AqueK679_Aque_RAF ------------------------------------------------------------ RAF1_Hsap_RAF ------------------------------------------------------------ KSR2_Hsap_KSR YFSRQLSCKKKVALQE--------------RNAEL-----DGFPQLRHWFRIVDVRKEVL KSR1_Hsap_KSR YICKQRQCKLSVAPGE--------------RTPEL-----NSYPRFSDWLYTFNVRPEVV phl_Dmel_RAF ------------------------------------------------------------ ksr_Dmel_KSR YFSELLLAKMR--LNE--------------RIPANGLVPHTTGNELRQWLRVVGLSQGTL KSR2_Mmus_KSR YFSRQLSCKKKVALQE--------------RNAEL-----DGFPQLRHWFRIVDVRKEVL KSR1_Mmus_KSR YICKQQQSKLSVTPSD--------------RTAEL-----NSYPRFSDWLYIFNVRPEVV BRAF_Mmus_RAF ------------------------------------------------------------ ARAF_Mmus_RAF ------------------------------------------------------------ lin-45_Cele_RAF ------------------------------------------------------------ ksr-2_Cele_RAF ------------------------------------------------------------ ksr-1_Cele_KSR AVY---QMT-KIGLID-------------REKREI-----NA-----IWFTFVGLSAQNI BRAF_Hsap_RAF ------------------------------------------------------------ ARAF_Hsap_RAF ------------------------------------------------------------ RAF1_Mmus_RAF ------------------------------------------------------------ KSR1_Spur_KSR ------------------------------------------------------------ Raf_Spur_RAF ------------------------------------------------------------ KSR2_Spur_KSR ------------------------------------------------------------ AqueK675_Aque_KSR ---------------H-------------HQQ---------------------------- AqueK676_Aque_KSR LFSRQLMHK-HICLKELINAGGVSHFDFEQTNDEL-----DSLISFKMFLTVTGLEELSV AqueK677_Aque_RAF ------------------------------------------------------------ AqueK678_Aque_RAF ------------------------------------------------------------ AqueK679_Aque_RAF ------------------------------------------------------------ RAF1_Hsap_RAF ---------------------------------------------------------G-- KSR2_Hsap_KSR EEIS--PGQLSLEDLLEMTDEQVCETVEKYGAN--REECARLNASLSCLRNVH------- KSR1_Hsap_KSR QEI---PRDLTLDALLEMNEAKVKETLRRCGAS--GDECGRLQYALTCLRKVT------- phl_Dmel_RAF ---------------------------------------------------------ANL ksr_Dmel_KSR TACL--ARLTTLEQSLRLSDEEIRQLLADSPSQREEEELRRLTRAMQNLRKCM------- KSR2_Mmus_KSR EEIS--PDQLSLEDLLEMTDEQVCETVEKYGAN--QEECARLNASLSCLRNVH------- KSR1_Mmus_KSR QEI---PQELTLDALLEMDEAKAKEMLRRWGAS--TEECSRLQQALTCLRKVT------- BRAF_Mmus_RAF ---------------------------------------------------------GGE ARAF_Mmus_RAF ------------------------------------------------------------ lin-45_Cele_RAF ------------------------------------------------------------ ksr-2_Cele_RAF ------------------------------------------------TTS--------- ksr-1_Cele_KSR RHLEI-CSITDFNALFSITNQELRSLADRGRLD--VETKRKLLQSTVILQNHW------- BRAF_Hsap_RAF ---------------------------------------------------------GGE ARAF_Hsap_RAF ------------------------------------------------------------ RAF1_Mmus_RAF ---------------------------------------------------------G-- KSR1_Spur_KSR ----------------KHGESEIRTIMKICGC--EEKEITRLLDAVKNLKKTF------- Raf_Spur_RAF ---------------------------------------------------------GTE KSR2_Spur_KSR ------------------------------------------------------------ AqueK675_Aque_KSR ------------------------------------------------------------ AqueK676_Aque_KSR KSLSSEKEKLSVDRLFQMTPQELQYLFSRLEIT--ARDCHKLVSLLDLMSLYYEKWEKGE AqueK677_Aque_RAF ---------------------------------------------------------PYG AqueK678_Aque_RAF ---------------------------------------------------------INI AqueK679_Aque_RAF ------------------------------------------------------------ RAF1_Hsap_RAF ------------------------------------------------------------ KSR2_Hsap_KSR ------------------MS--------------GGN---LSKQDWTIQWPTTET----G KSR1_Hsap_KSR ------------------GL--------------GGE---H-KED--SSWSSLDARRESG phl_Dmel_RAF QEPPAMYLIEYQELTSKLHELEAKEQELMERLNSQDQQED-------S-----S------ ksr_Dmel_KSR ------------------E-----------SLESGTAASNNDPEQ--WHWDSWDRPTHIH KSR2_Mmus_KSR ------------------KS--------------GGN---LSKQDWIIQWPTTEP----G KSR1_Mmus_KSR ------------------GL--------------GGE---H-KMD--SGWSSTDARDSS- BRAF_Mmus_RAF HNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGADFSV-------S-----S------ ARAF_Mmus_RAF ------------------------------------------------------------ lin-45_Cele_RAF --------ISLP------------------------RCAS-------S-----S------ ksr-2_Cele_RAF --------------------SFSSWRR---SSTSG------------------------- ksr-1_Cele_KSR ------------------------NAYHSR-TSSGST----------------D------ BRAF_Hsap_RAF HNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSV-------S-----S------ ARAF_Hsap_RAF ------------------------------------------------------------ RAF1_Mmus_RAF ------------------------------------------------------------ KSR1_Spur_KSR ------------------NANYPSKDR---SLEDGAKS--------------PDAVS--- Raf_Spur_RAF QPPPPIFLEEYQDLTDQLSELQVEEQRINNEMSNGHT----------------------- KSR2_Spur_KSR ------------------------------------------------------------ AqueK675_Aque_KSR -------------------------------KTRGTD----------------------- AqueK676_Aque_KSR NPPPGLYDVRRNSSSGRLNSLTSLESRKDS-TSSHTI----------------S------ AqueK677_Aque_RAF QR-TSLVVEEESELKKRLEDLMRREKELSG---QGWDSS--------------D------ AqueK678_Aque_RAF RESPSMAAGAVEVVTNQVEEREAA-KECVESLVSQHRKE--------------D------ AqueK679_Aque_RAF ------------------------------------------------------------ RAF1_Hsap_RAF ------------------------------------------------------------ KSR2_Hsap_KSR -----------K---ENNPVCPPEPTPWIRT-HLSQSPRVPSK------------CVQHY KSR1_Hsap_KSR SGPSTD---TLS---AASLPWPPGSSQLGRAGNSAQGPRS-------------------- phl_Dmel_RAF -LVERF---KEQ--PHYQNQT-------------QILQ---------------------- ksr_Dmel_KSR RGSVG-----N--------------IGLG--NNSTASPRTHHRQHGVKGKNSALANSTNF KSR2_Mmus_KSR -----------Q---ESNPVCPPEPSPWIRT-HLSQSPRVQTK------------CPQHF KSR1_Mmus_KSR LGPPMD---ML--------------SSLGRAGASTQGPRS-------------------- BRAF_Mmus_RAF -SASMD---TVT--SSSSSSL-------------SVLP---------------------- ARAF_Mmus_RAF ------------------------------------------------------------ lin-45_Cele_RAF -IDRKD---QAS--PMASPST-------------PLYP---------------------- ksr-2_Cele_RAF --S------------------------------ISQSSRTTSK------------TT--- ksr-1_Cele_KSR -EP--------S--GQSTPAI-------------V-TP-----------------SPKF- BRAF_Hsap_RAF -SASMD---TVT--SSSSSSL-------------SVLP---------------------- ARAF_Hsap_RAF ------------------------------------------------------------ RAF1_Mmus_RAF ------------------------------------------------------------ KSR1_Spur_KSR MGNSIE---TV--------------IDLS--RSRSNSPSV-------------------- Raf_Spur_RAF -SPNLQ---TTP--PPEPADL-------------H-VP---------------------- KSR2_Spur_KSR ------------------------------------------------------------ AqueK675_Aque_KSR ---------------QSSPVN-------------V------------------------- AqueK676_Aque_KSR -PPAGN---HGS--RSSTPLT-------------PLTP-----------------SSTQS AqueK677_Aque_RAF -SAEQE---LVS--SSSPDGS-------------DQSP---------------------- AqueK678_Aque_RAF -CQQKECLKIDEYGISSIS----------------------------------------- AqueK679_Aque_RAF ------------------------------------------------------------ RAF1_Hsap_RAF ------------------------------------------------------------ KSR2_Hsap_KSR CHTSPTPG--APVYTHVDRLT--VDAYPGLC----------------------------- KSR1_Hsap_KSR -------------------IS--VSALPASD----------------------------- phl_Dmel_RAF ------------------------------------------------------------ ksr_Dmel_KSR KSGRQSPSA-------TEELNSTQGSQLTLT----------------------------- KSR2_Mmus_KSR CPTSPTPG--TPVYTQVDRLT--VDAYPNLC----------------------------- KSR1_Mmus_KSR -------------------IS--VSALPASD----------------------------- BRAF_Mmus_RAF ------------------------------------------------------------ ARAF_Mmus_RAF ------------------------------------------------------------ lin-45_Cele_RAF ------------------------------------------------------------ ksr-2_Cele_RAF ---TSS--------------S--VTSSNPIN----------------------------- ksr-1_Cele_KSR ---------N----------------VPSLSV---------------------------- BRAF_Hsap_RAF ------------------------------------------------------------ ARAF_Hsap_RAF ------------------------------------------------------------ RAF1_Mmus_RAF ------------------------------------------------------------ KSR1_Spur_KSR ---SSSPEQKRP---SIDSLSSDLSEVPSVP----------------------------- Raf_Spur_RAF -------------------------------YHNK------------------------- KSR2_Spur_KSR ------------------------------------------------------------ AqueK675_Aque_KSR ---------A----------------VPSITV---------------------------- AqueK676_Aque_KSR PFQGLVHQNS----------------TPSIPTHSVPYDNIRSTSSCGCGGHALSESSGQH AqueK677_Aque_RAF ------------------------------------------------------------ AqueK678_Aque_RAF ------------------------------------------------------------ AqueK679_Aque_RAF ------------------------------------------------------------ RAF1_Hsap_RAF ----------------------------------------------Y-QRRA--SD---- KSR2_Hsap_KSR ---------------------------------------------P--P-PP--LESGHR KSR1_Hsap_KSR ---------------------------------------------SP-T-PS--FSEGLS phl_Dmel_RAF --------------------------Q----QR----------QLARVHHGNDLTD---- ksr_Dmel_KSR ---------------------------------------------LT-P-SP-------- KSR2_Mmus_KSR ---------------------------------------------PP-P-PP--LESGHR KSR1_Mmus_KSR ---------------------------------------------SP-V-PG--LSEGLS BRAF_Mmus_RAF --------------------------S----------------SLSV-FQTP--TD---- ARAF_Mmus_RAF ------------------------------------------------------------ lin-45_Cele_RAF --------------------------KHSDSLH----------SLSG-HHSA--GG---- ksr-2_Cele_RAF ---------------------------------------------AP-P-PT--ATS--- ksr-1_Cele_KSR ---------------------------------------T---SAKM-IQSS--SM---- BRAF_Hsap_RAF --------------------------S----------------SLSV-FQNP--TD---- ARAF_Hsap_RAF ------------------------------------------------------------ RAF1_Mmus_RAF ----------------------------------------------Y-QRRA--SD---- KSR1_Spur_KSR ---------------------------------------------IT-P-PP--FNNKIF Raf_Spur_RAF --------------------------Q----------------SLAP-PHKR--EF---- KSR2_Spur_KSR ------------------------------------------------------------ AqueK675_Aque_KSR ---------------------------------------SSPRSRSN-SRNA--VI---- AqueK676_Aque_KSR LSSSMSSLGSDLGLHVAHSNETTHLPTA-SNQSHDVYQTTPPAPPTY-SSSL--RA---- AqueK677_Aque_RAF --------------------------R----------------GPLS-PRNP--LT---- AqueK678_Aque_RAF ------------------------------------------------------------ AqueK679_Aque_RAF ------------------------------------------------------------ RAF1_Hsap_RAF --DG----------------------------------KL-------------------- KSR2_Hsap_KSR --S---LPPSPRQRHAVRTPPRTPNIVTT---------VT----PPGTPPMRK----KNK KSR1_Hsap_KSR DTC---IPLHA----SGRLTPRAL--HSF---------IT----PPTTPQLRR----HTK phl_Dmel_RAF --SL----------------------------------GSQPGSQCG------------- ksr_Dmel_KSR --------------------------------------PN----SPFTPSSGLSSSLNGT KSR2_Mmus_KSR --S---LPPSPRQRHVVRTPPRTPNIVTT---------VT----PPGTPPMRR----KNK KSR1_Mmus_KSR DSC---IPLHT----SGRLTPRAL--HSF---------IT----PPTTPQLRR----HAK BRAF_Mmus_RAF --AS----------------------------------RN-------------------- ARAF_Mmus_RAF ------------------------------------------------------------ lin-45_Cele_RAF --AG----------------------------------TS-----DK------------- ksr-2_Cele_RAF -----------------------------------------------------SSSV--L ksr-1_Cele_KSR ------------------------------------GFAT-------------------- BRAF_Hsap_RAF --VA----------------------------------RS-------------------- ARAF_Hsap_RAF ------------------------------------------------------------ RAF1_Mmus_RAF --DG----------------------------------KL-------------------- KSR1_Spur_KSR --K---LPP-------------------M---------PT----PPHTPTFNK------- Raf_Spur_RAF --TN----------------------------------QQ-------------------- KSR2_Spur_KSR ------------------------------------------------------------ AqueK675_Aque_KSR ------------------------------------GGNG-------------------- AqueK676_Aque_KSR -KK----KIGHT-RS-HSNPPLANLIMPEAVPENSVPEYR-------------------- AqueK677_Aque_RAF --VSHSYPLSPV-RHLPPLPPVTVSIEND---------TV----APS------------- AqueK678_Aque_RAF --------------------------------------------KCT------------- AqueK679_Aque_RAF ------------------------------------------------------------ RAF1_Hsap_RAF ---TD--P---------------------------------------------------- KSR2_Hsap_KSR L-KPP--G---------------------------------------------------- KSR1_Hsap_KSR L-KPP--R---------------------------------------------------- phl_Dmel_RAF ---TL--T---------------------------------------------------- ksr_Dmel_KSR PQRSR--G---------------------------------------------------- KSR2_Mmus_KSR L-KPP--G---------------------------------------------------- KSR1_Mmus_KSR L-KPP--R---------------------------------------------------- BRAF_Mmus_RAF ---NP--K---------------------------------------------------- ARAF_Mmus_RAF ----E--P---------------------------------------------------- lin-45_Cele_RAF ---EP--P---------------------------------------------------- ksr-2_Cele_RAF PS-TS--S---------------------------------------------------- ksr-1_Cele_KSR ---TP------------------------------------------------------- BRAF_Hsap_RAF ---NP--K---------------------------------------------------- ARAF_Hsap_RAF ----E--P---------------------------------------------------- RAF1_Mmus_RAF ---TD--S---------------------------------------------------- KSR1_Spur_KSR --RVK--G---------------------------------------------------- Raf_Spur_RAF ---HP--K---------------------------------------------------- KSR2_Spur_KSR ------------------------------------------------------------ AqueK675_Aque_KSR ---YP------------------------------------------------------- AqueK676_Aque_KSR ---SPSPPYYNGHAPPTRTGSHPSIIHNSIANSNQSLANSTSTKSHPQVRRLMAGNYNFS AqueK677_Aque_RAF ---SP--V---------------------------------------------------- AqueK678_Aque_RAF ---TL--L---------------------------------------------------- AqueK679_Aque_RAF ------------------------------------------------------------ RAF1_Hsap_RAF -------------S-----KTSNTIRVFLPNKQRTVVNVRNGMSLHDC-LMKALKVRGLQ KSR2_Hsap_KSR -------------T-----PPPSSRKL-----------------------------IHLI KSR1_Hsap_KSR -------------T-----PPPPSRKV-----------------------------FQLL phl_Dmel_RAF -------------R-----QPKILLRAHLPNQQRTSVEVISGVRLCDA-LMKALKLRQLT ksr_Dmel_KSR -------------------TPPPARKH-----------------------------QTLL KSR2_Mmus_KSR -------------T-----PPPSSRKL-----------------------------IHLI KSR1_Mmus_KSR -------------T-----PPPPSRKV-----------------------------FQLL BRAF_Mmus_RAF -------------S-----PQKPIVRVFLPNKQRTVVPARCGVTVRDS-LKKALMMRGLI ARAF_Mmus_RAF -------------S-----RAVGTVKVYLPNKQRTVVTVREGMSVYDS-LDKALKVRGLN lin-45_Cele_RAF -------------K-----FKYKMIMVHLPFDQHSRVEVRPGETARDA-ISKLLKKRNIT ksr-2_Cele_RAF -------------E-----PPPPASA---------------------------------- ksr-1_Cele_KSR ------------------------------------------------------------ BRAF_Hsap_RAF -------------S-----PQKPIVRVFLPNKQRTVVPARCGVTVRDS-LKKALMMRGLI ARAF_Hsap_RAF -------------S-----RAVGTVKVYLPNKQRTVVTVRDGMSVYDS-LDKALKVRGLN RAF1_Mmus_RAF -------------S-----KTSNTIRVFLPNKQRTVVNVRNGMSLHDC-LMKALKVRGLQ KSR1_Spur_KSR -------------K-----TPPLTRKT-----------------------------NLPL Raf_Spur_RAF -------------S-----PLSQSVRAFLPNQQRTSVLAKSGTTLKYC-LSKAMKMRELT KSR2_Spur_KSR ----------------------------------------------EQ-L---------- AqueK675_Aque_KSR ------------------------------------------------------------ AqueK676_Aque_KSR RSISTDLGDVQPDPPLRSNSEASSVQSASPRQRRLSKEVGTSTSMVDLPLIQCSVEQSEF AqueK677_Aque_RAF -------------T-----THAALIRAHLPEGQRTIVPIRQGVTIQDA-LMKAMKTRNLT AqueK678_Aque_RAF -------------R-----EKQVLIRAHLPEGQRTIVPIRQGVTIQDA-LMKAMKTRNLT AqueK679_Aque_RAF ------------------------------------------------------------ RAF1_Hsap_RAF PECCAVFRLLHEHKGKKA-----------------------RLDWNTD--AASLIGEELQ KSR2_Hsap_KSR PGFTALHRSK---S-HEF-QLGHRVDEAHTPKAKKKSK-----PLNLK--IHSSVGSCEN KSR1_Hsap_KSR PSFPTLTRSK---S-HES-QLGNRIDDVSS------------------------------ phl_Dmel_RAF PDMCEVSTTH---SG-RH-----------------------IIPWHTD--IGTLHVEEIF ksr_Dmel_KSR SQ------------------SHVQVDGEQLARNRL------PTDPSPD--SHSSTSSDIF KSR2_Mmus_KSR PGFTALHRSK---S-HEF-QLGNRVDEANTPKAKKKSK-----PLNLK--IHSGVGSCEN KSR1_Mmus_KSR PSFPTLTRSK---S-HES-QLGNRIDDVTP------------------------------ BRAF_Mmus_RAF PECCAVYRIQ---DGEKK-----------------------PIGWDTD--ISWLTGEELH ARAF_Mmus_RAF QDCCVVYRLI---KGRKT-----------------------VTAWDTA--IAPLDGEELI lin-45_Cele_RAF PQLCHVNASS---DPKQE-S---------------IEL---SLTMEEI--ASRLPGNELW ksr-2_Cele_RAF ------------------------------------------------------------ ksr-1_Cele_KSR ------------------------------------------------------------ BRAF_Hsap_RAF PECCAVYRIQ---DGEKK-----------------------PIGWDTD--ISWLTGEELH ARAF_Hsap_RAF QDCCVVYRLI---KGRKT-----------------------VTAWDTA--IAPLDGEELI RAF1_Mmus_RAF PECCAVFRLLQEHKGKKA-----------------------RLDWNTD--AASLIGEELQ KSR1_Spur_KSR PAQSNWNSDN---H-LNK-RSGPGYDSATLGRIQVRSRDQHTRRYSDDQSVMRLSSPCRS Raf_Spur_RAF PEMCIVYRVN-----PRM-----------------------ALSWDTD--MMYLAGEEIS KSR2_Spur_KSR ------------------------------------------------------------ AqueK675_Aque_KSR ------------------------------------------------------------ AqueK676_Aque_KSR PSSSVKSHSV-----PRLAN---------------LTI-------NT------TTGDHNS AqueK677_Aque_RAF PNTCIVYAE-----SPRL-----------------------LIEWDTD--TTQLSGKEVF AqueK678_Aque_RAF PNTCIVYAE-----SPRL-----------------------LIEWDTD--TTQLSGKEVF AqueK679_Aque_RAF ------------------------------------------------------------ RAF1_Hsap_RAF V--------------------------------------------D--------FL-DHV KSR2_Hsap_KSR IPSQQRSPLLSERSLRSFFVGHAPFLPSTPPVHTEANFSANTLSVPRWSPQIP---R--R KSR1_Hsap_KSR ----------------------------------------MRFDLSHGSPQMV---R--R phl_Dmel_RAF V--------------------------------------------R--------LL-DKF ksr_Dmel_KSR VDPNTNASS---------------------------GGSSSNVLMVPCSPGVG---H--V KSR2_Mmus_KSR IPAQQRSPLLSERSLRSFFVGHGPFLPSTPPVHTEANFSANTLSVPRWSPQIP---R--R KSR1_Mmus_KSR ----------------------------------------MKFELPHGSPQLV---R--R BRAF_Mmus_RAF V--------------------------------------------E--------VL-ENV ARAF_Mmus_RAF V--------------------------------------------E--------VL-EDV lin-45_Cele_RAF V------------------------------------------HSE--------YL-NTV ksr-2_Cele_RAF ------------------------------------------------------------ ksr-1_Cele_KSR -----------------------------------------------KSPKTSS------ BRAF_Hsap_RAF V--------------------------------------------E--------VL-ENV ARAF_Hsap_RAF V--------------------------------------------E--------VL-EDV RAF1_Mmus_RAF V--------------------------------------------D--------FL-DHV KSR1_Spur_KSR EERLTDIGV----------------------------PPKQGKLVPPKSPRAT---H-RS Raf_Spur_RAF V--------------------------------------------E--------LKAQNF KSR2_Spur_KSR ---------------------------------------------------------QK- AqueK675_Aque_KSR -----------------------------------------------QPP--AS------ AqueK676_Aque_KSR T------------------------------------------SVP-TSPRIPTNYNPTG AqueK677_Aque_RAF V--------------------------------------------E--------YQ-KSP AqueK678_Aque_RAF V--------------------------------------------V--------VF-MAY AqueK679_Aque_RAF ------------------------------------------------------------ RAF1_Hsap_RAF P---L---TTHNFARKTFLKLAFCDICQKFL-L----------NGF-----RCQTCGYKF KSR2_Hsap_KSR DLGNS---IKHRFSTKYWMS-QTCTVCGKGM-L----------FGL-----KCKNCKLKC KSR1_Hsap_KSR DIGLS---VTHRFSTKSWLS-QVCHVCQKSM-I----------FGV-----KCKHCRLKC phl_Dmel_RAF PIRTH---IKHQIIRKTFFSLVFCEGCRRLL-F----------TGF-----YCSQCNFRF ksr_Dmel_KSR GMGHA---IKHRFTKALGF-MATCTLCQKQV-FH---------RWM-----KCTDCKYIC KSR2_Mmus_KSR DLGNS---IKHRFSTKYWMS-QTCTVCGKGM-L----------FGL-----KCKNCKLKC KSR1_Mmus_KSR DIGLS---VTHRFSTKSWLS-QVCNVCQKSM-I----------FGV-----KCKHCRLKC BRAF_Mmus_RAF P---L---TTHNFVRKTFFTLAFCDFCRKLL-F----------QGF-----RCQTCGYKF ARAF_Mmus_RAF P---L---TMHNFVRKTFFSLAFCDFCLKFL-F----------HGF-----RCQTCGYKF lin-45_Cele_RAF ---SS---IKHAIVRRTFIPPKSCDVCNNPIWM----------MGF-----RCEFCQFKF ksr-2_Cele_RAF PPRIS---IYHKMVPSKSK-FRQCDVCEHIF-IFDFVRKQHLDDVY-----ACNVCGIRV ksr-1_Cele_KSR RLVHAIPHKWHRSTKFRFSGDAVCHFCQRPLG-----------FGFLNAWEKCRSCKWKV BRAF_Hsap_RAF P---L---TTHNFVRKTFFTLAFCDFCRKLL-F----------QGF-----RCQTCGYKF ARAF_Hsap_RAF P---L---TMHNFVRKTFFSLAFCDFCLKFL-F----------HGF-----RCQTCGYKF RAF1_Mmus_RAF P---L---TTHNFARKTFLKLAFCDICQKFL-L----------NGF-----RCQTCGYKF KSR1_Spur_KSR NMIHA---IKHRFSKKTSMKPQSCDYCHEKIVIL---------QRY-----KCKDCKYIC Raf_Spur_RAF PAPSS---ISHNFVRKTFFAIAFCDSCQKLL-F----------HGF-----RCQTCSYKF KSR2_Spur_KSR TLLLR---AKHCYTRQLVSPAKRCDFCKKSMFV----------MTL-----RCKDCRVRC AqueK675_Aque_KSR PLLHWSTG---------------------------------------------------- AqueK676_Aque_KSR VMGHK---IDHRFINHIFFGVQECDYCKKSMVV----------SGY-----RCRYCKSKF AqueK677_Aque_RAF KLAST---NHHNFVRKTFIALAFCDVCKKLL-F----------QGF-----RCETCGFRY AqueK678_Aque_RAF PFLSL---FHHFFVRKTFIALAFCDVCKKLL-F----------QGF-----RCETCGFRY AqueK679_Aque_RAF ------------------------------------------------------------ RAF1_Hsap_RAF HEHCSTK---VPTMCVDWSN----IRQ---LLLFP-NS-TI---------------GD-S KSR2_Hsap_KSR HNKCTKE---APP-CHLLIIHRGDPAR---LVRTESVPCDI---------------NN-P KSR1_Hsap_KSR HNKCTKE---APA-CRISFLPL---TR---LRRTESVPSDI---------------NN-P phl_Dmel_RAF HQRCANR---VPMLCQPFPMDS--YYQ---LLLAENPDNGV---------------GF-P ksr_Dmel_KSR HKSCAPH---VPPSCGLPREYV---DE---FRHIKEQGGYA---------------SL-P KSR2_Mmus_KSR HNKCTKE---APP-CHLLIIHRGDPAR---LVRTESVPCDI---------------NN-P KSR1_Mmus_KSR HNKCTKE---APA-CRITFLPL---AR---LRRTESVPSDI---------------NN-P BRAF_Mmus_RAF HQRCSTE---VPLMCVNYDQ----LDL---LFVSKFFE-HH---------------PV-P ARAF_Mmus_RAF HQHCSSK---VPTVCVDMST----NRR---QFYHSIQD-LS---------------GG-S lin-45_Cele_RAF HQRCSSF---APLYCDLLQSVP--KNE---DLV---KE-LF---------------GI-A ksr-2_Cele_RAF HKGCLDR---VKNDCKITTQYM---GG---ILENAVIQS--------------------- ksr-1_Cele_KSR HTQCKGR---VGDSCGLTPDHL---RF---LFDKLIQE-NN---------------GGMW BRAF_Hsap_RAF HQRCSTE---VPLMCVNYDQ----LDL---LFVSKFFE-HH---------------PI-P ARAF_Hsap_RAF HQHCSSK---VPTVCVDMST----NRQ---QFYHSVQD-LS---------------GG-S RAF1_Mmus_RAF HEHCSTK---VPTMCVDWSN----IRQ---LLLFP-NS-TV---------------GD-S KSR1_Spur_KSR HSNCKFHAEKVPS-CGLPRKYE---EI---FRETINS--AR---------------TD-P Raf_Spur_RAF HQRCANK---VPTICISTTGDN--LYK---LLLALRKE-D-----------------D-Y KSR2_Spur_KSR HRRCAQQ---AANLCELAAKHN---------LTTGPES-RN------------------- AqueK675_Aque_KSR --------------------------------------------------------R--- AqueK676_Aque_KSR HKNCSKL---APPICGLPKYFL---NYARQHFMMSPSH-ESVYQVNKTGHLTSSGEYGSC AqueK677_Aque_RAF HQRCSPR---VPIQCGGVDDDL--IMA---YILSQ----HP---------------PK-P AqueK678_Aque_RAF HQRCSPR---VPIQCGGVDDDL--IMA---YILSQ----HP---------------PK-P AqueK679_Aque_RAF ------------------------------------------------------------ RAF1_Hsap_RAF G-V-----------------------P-ALPS-------L------------------T- KSR2_Hsap_KSR LRKPPRYSDLHISQTLPKTNKINKD----HIP-------VPYQ---------------P- KSR1_Hsap_KSR VDR---AAEPHF-GTLPKAL-TKKE----HPP-------AMNH---------------L- phl_Dmel_RAF G-R-----------------------G-TAVR-------F------------------N- ksr_Dmel_KSR ----------HVHGAAKGSPLVKKSTL-GKPL-------HQQH---------------G- KSR2_Mmus_KSR VRKPARYSDLHISQTLPKTNKINKD----HIP-------VPYQ---------------P- KSR1_Mmus_KSR VDR---AAEPHF-GTLPKAL-TKKE----HPP-------AM-N---------------L- BRAF_Mmus_RAF Q-E-----------------------E-AS---------F------------------P- ARAF_Mmus_RAF R-Q-----------------------Q-EAPS-------N-------------------- lin-45_Cele_RAF S-Q-----------------------V-EGPDRSVAEIVL------------------A- ksr-2_Cele_RAF -------------------NK-KQ--W-EKPT-------TASI---------------SK ksr-1_Cele_KSR K-D-----------------------PQSVPG-------S--RSMNEPA------FQFP- BRAF_Hsap_RAF Q-E-----------------------E-AS---------L------------------A- ARAF_Hsap_RAF R-Q-----------------------H-EAPS-------N-------------------- RAF1_Mmus_RAF G-V-----------------------P-APPS-------F------------------P- KSR1_Spur_KSR ----------P--------------TV-VN-V-------ASST---------------G- Raf_Spur_RAF --------------------------N-DYPD---------------------------- KSR2_Spur_KSR V-V-----------------------PT--C----------------------------- AqueK675_Aque_KSR -----------------------------------------------RV------WSEP- AqueK676_Aque_KSR N-T-----------------------PT--PS-------S--EQLREETFFIHDLNREP- AqueK677_Aque_RAF --------------------------D-DS----------------------------P- AqueK678_Aque_RAF --------------------------D-DS----------------------------P- AqueK679_Aque_RAF ------------------------------------------------------------ RAF1_Hsap_RAF ---------MRRMRES-VS--RMPVSS-----------------QH--RYSTPHAF-TFN KSR2_Hsap_KSR DSS----S-NPSSTTS-STP-SSPAP----PLP------PSATP----PS-PLHPS-P-- KSR1_Hsap_KSR DSS----S-NPSSTTS-STP-SSPAP----F-P------TSSNP----SSATTPPN-P-- phl_Dmel_RAF ---------MSSRSRSRRCS-SSGSSSSSKPPS------SSSG-NH--R----------- ksr_Dmel_KSR DSS----S-PSSSCTS-STP-SSPAL----FQQRERELDQAGS--S--SSANLLPT-P-- KSR2_Mmus_KSR DSS----S-NPSSTTS-STP-SSPAP----PLP------PSATP----PS-PLHPS-P-- KSR1_Mmus_KSR DSS----S-NPSSTTS-STP-SSPAP----F-L------TSSNP----SSATTPPN-P-- BRAF_Mmus_RAF ---------ETALPSG-SS--SAPPSDSTGPQI------LTSP-SP--SKSIPIPQ-PFR ARAF_Mmus_RAF ----------LSVNEL-LTP-QGPSP------------------FT--QQRDQEHF-SF- lin-45_Cele_RAF ---------NLAPTSG-QSPAATPD--SSHPDL------TSIK-RTGGVKRHPMAVSPQN ksr-2_Cele_RAF SLT----T-SPTCST--STT-MSPA----------------GVE-----SML-------- ksr-1_Cele_KSR DTA----IDSSSSTNS-SAP-STPAL----PAG------ISGN----------------- BRAF_Hsap_RAF ---------ETALTSG-SSP-SAPASDSIGPQI------LTSP-SP--SKSIPIPQ-PFR ARAF_Hsap_RAF ----------RPLNEL-LTP-QGPSP------------------RT--QHCDPEHF-PF- RAF1_Mmus_RAF ---------MRRMRES-VS--RMPASS-----------------QH--RYSTPHAF-TFN KSR1_Spur_KSR DSS----S-NPSSTTS-STP-SSPAP----FIS------TSGIPLP--SPSPALPS-P-- Raf_Spur_RAF -------------TFP-DEP-ESPSSDD-------------QD----------------- KSR2_Spur_KSR ----HAALAEASRRHQ-SAN-STPVPTH-RRKS------STES--F--REIETHQS---- AqueK675_Aque_KSR GGS----SGLSA-SSL-LVD--------------------S-G----------------- AqueK676_Aque_KSR SKNQFSPVTSTKRPHP-PAP-SSPAHDH-APFS------SSHS--T--SRLEVPQL--FL AqueK677_Aque_RAF ---------Q---PSS-PVP-HSPT----VPLL----------------------V-PTK AqueK678_Aque_RAF ---------Q---PSS-PVP-HSPT----VPLL----------------------V-PTK AqueK679_Aque_RAF ------------------------------------------------------------ RAF1_Hsap_RAF TSSPS--S--------------EGSLSQR-QRSTSTPNVHMVSTTLPV----DSRMIED- KSR2_Hsap_KSR ------------------------QCTRQ-QKNFNLPASHYYKY---------------- KSR1_Hsap_KSR ------------------------SPGQR-DSRFNFPAAYFIHH---------------- phl_Dmel_RAF ---QG--R--------------PPRISQD-DRSNSAPNVCINN-IRSVTSEVQRSLIM-- ksr_Dmel_KSR ------------------------SLGKHQPSQFNFPNVTVTSS---------------- KSR2_Mmus_KSR ------------------------QCPRQ-KKNFNLPASHYYKY---------------- KSR1_Mmus_KSR ------------------------SPGQR-DSRFSFPAAYFIHH---------------- BRAF_Mmus_RAF PADED--H--------------RNQFGQR-DRSSSAPNVHINT-IEPVN--IDEKFPEV- ARAF_Mmus_RAF ---PA--P--------------ANPPLQR-IRSTSTPNVHMVSTTAPM----DSSLMQF- lin-45_Cele_RAF ETSQL--S--------------PSGPYPR-DRSSSAPNINAINDEATVQHN--QRIL-D- ksr-2_Cele_RAF --------------------------E-------KWNKTKFLKN---------------- ksr-1_Cele_KSR -------------------VSSLTAPYRS-ERKFLFPDTENYS---------VH------ BRAF_Hsap_RAF PADED--H--------------RNQFGQR-DRSSSAPNVHINT-IEPVN--IDDL----- ARAF_Hsap_RAF ---PA--P--------------ANAPLQR-IRSTSTPNVHMVSTTAPM----DSNLIQL- RAF1_Mmus_RAF TSSPS--S--------------EGSLSQR-QRSTSTPNVHMVSTTLHV----DSRMIED- KSR1_Spur_KSR ------------------------SPRMM-VPQFKFPPDVSDDV---------------- Raf_Spur_RAF -------F--------------PRNTLPR-ERSTSAPNICQNAVNVPG----QQ--FDS- KSR2_Spur_KSR -------------------------TFSV-RRSTTRQRLS--TTTVPK----DHSLGRV- AqueK675_Aque_KSR -------------------RSSLTSY-GS-QESLLFTSPL-------------------- AqueK676_Aque_KSR PGVRS--HSNYRHPHHHRVPPHSTSSSPS-TSSQSSPCLTPMSPRSPL----DPPV-EYS AqueK677_Aque_RAF GGDEGETHSR------------FLNTSSR-ERSISTPNVLYNS---PAN--YDPYPTTT- AqueK678_Aque_RAF GGDEGETHSR------------FLNTSSR-ERSISTPNVLYNS---PAN--YDPYPTTT- AqueK679_Aque_RAF ------------------------------------------------------------ RAF1_Hsap_RAF ---------------AIRSHS----------------------------------E---- KSR2_Hsap_KSR -------------------KQ--QFIFPD------------------------------- KSR1_Hsap_KSR -------------------RQ--QFIFPVPSA----GHCW-------------------- phl_Dmel_RAF ------------------------------------------------------------ ksr_Dmel_KSR --------------------G----------------GSG-------------------- KSR2_Mmus_KSR -------------------KQ--QFIFPD------------------------------- KSR1_Mmus_KSR -------------------RQ--QFIFPD------------------------------- BRAF_Mmus_RAF ---------------ELQDQR--DLI-------RDQGFRGDGAPLNQLMRCLRKYQ---- ARAF_Mmus_RAF ---------------TAQSFS----------------------------------T---- lin-45_Cele_RAF ---------------ALEAQR----L-------E---------------------E---- ksr-2_Cele_RAF -------------------RE--NIC--K------------------------------- ksr-1_Cele_KSR -----NRLPILVISEGDHPTTT--EI-------Q---------------------QE--- BRAF_Hsap_RAF -------------------------I-------RDQGFRGDGAPLNQLMRCLRKYQ---- ARAF_Hsap_RAF ---------------TGQSFS----------------------------------T---- RAF1_Mmus_RAF ---------------AIRSHS----------------------------------E---- KSR1_Spur_KSR --------------------S--------------------------------------- Raf_Spur_RAF -----------------EAFS--RFAFPVKSSLN---------P---------NGH---- KSR2_Spur_KSR ---------------SRSTLSSQSSN-------R---------------------SSVSG AqueK675_Aque_KSR ------------------------------------------------------------ AqueK676_Aque_KSR GFNSLHRSIAIVLSTDDNTSSTDEEG-------D---------------------GPDGE AqueK677_Aque_RAF -----------------EDNR--EFLGPMPF-------SS-------------VSG---- AqueK678_Aque_RAF -----------------EDNR--EFLGPMPF-------SS-------------VSG---- AqueK679_Aque_RAF ------------------------------------------------------------ RAF1_Hsap_RAF -------SASPS------------------------------------------A----- KSR2_Hsap_KSR --------------------------------------------VVPVPETPTRAPQV-- KSR1_Hsap_KSR ----------KCL-LIA--------------ESLKEN-AFN---ISAFAH---AAP---- phl_Dmel_RAF ------------------------------------------------------------ ksr_Dmel_KSR ----------GVS-LIS--------------NE-------------PVPEQFPTAPAT-- KSR2_Mmus_KSR --------------------------------------------VVPVPETPTRAPQV-- KSR1_Mmus_KSR --------------------------------------------ISACSQ---AAP---- BRAF_Mmus_RAF -------SRTPSP-LLH--------------SVPSEI-VFD-FEPGPVFRGSTTG--L-- ARAF_Mmus_RAF -------DAAG-----------------------------------------RG---G-- lin-45_Cele_RAF -------ESR----------------------------------------DKT------- ksr-2_Cele_RAF --------------------------------------------IE-------------- ksr-1_Cele_KSR ----TEN-------------------HNK----------------S--------A--AA- BRAF_Hsap_RAF -------SRTPSP-LLH--------------SVPSEI-VFD-FEPGPVFRGSTTG--L-- ARAF_Hsap_RAF -------DAAGS----------------------------------------RGG--S-- RAF1_Mmus_RAF -------SASPS------------------------------------------A----- KSR1_Spur_KSR -------------------------------------------------E---------- Raf_Spur_RAF -------TASAAV-NIHGAHGGGHGKVLTPNSAVQDG-VFD-YDPTNIANDGHTA--SAA KSR2_Spur_KSR Y-YS---QESDASLLS-------------ECDTPKEISVFDSFGPG--------D--VT- AqueK675_Aque_KSR ------------------------------------------------------------ AqueK676_Aque_KSR FYEGSEGFTSDSSNSSFNEVGLVGPAHNRGLKLP------------------------S- AqueK677_Aque_RAF -------SYVDNH-LSH--------------STEYNS-VFD-YNVSSSGNSSRDA--PIA AqueK678_Aque_RAF -------SYVDNH-LSH--------------STEYNS-VFD-YNVSSSGNSSRDA--PIA AqueK679_Aque_RAF ------------------------------------------------------------ RAF1_Hsap_RAF ------------------------------------------------------------ KSR2_Hsap_KSR ------------------------------------------------------------ KSR1_Hsap_KSR ------------------------------------------------------------ phl_Dmel_RAF ------------------------------------------------------------ ksr_Dmel_KSR ----------------------ANGGLDS------------------------------- KSR2_Mmus_KSR ------------------------------------------------------------ KSR1_Mmus_KSR ------------------------------------------------------------ BRAF_Mmus_RAF ------------------------------------------------------------ ARAF_Mmus_RAF ------------------------------------------------------------ lin-45_Cele_RAF ------------------------------------------------------------ ksr-2_Cele_RAF ------------------------------------------------------------ ksr-1_Cele_KSR ------------------------------------------------------------ BRAF_Hsap_RAF ------------------------------------------------------------ ARAF_Hsap_RAF ------------------------------------------------------------ RAF1_Mmus_RAF ------------------------------------------------------------ KSR1_Spur_KSR ------------------------------------------------------------ Raf_Spur_RAF VNIHGAH---GG-------------------------GHGK------------------- KSR2_Spur_KSR ------------------------------------------------------------ AqueK675_Aque_KSR ------------------------------------------------------------ AqueK676_Aque_KSR ------------------------RGIA-------------------------------- AqueK677_Aque_RAF HPPHSRRGLCGRGHISTSALETSHTGMDAMRIERRRKGHKRQSSAGHLDYSGVEDSKERR AqueK678_Aque_RAF HPPHSRRGLCGRGHISTSALETSHTGMDAMRIERRRKGHKRQSSAGHLDYSGVEDSKERR AqueK679_Aque_RAF ------------------------------------------------------------ RAF1_Hsap_RAF ------------------------------------------------------------ KSR2_Hsap_KSR -------------------------------------------------------I---- KSR1_Hsap_KSR ------------------------------------------------------------ phl_Dmel_RAF ------------------------------------------QAR--------------- ksr_Dmel_KSR --------------------------------------------LVSSSNGHMSSLIGSQ KSR2_Mmus_KSR -------------------------------------------------------I---- KSR1_Mmus_KSR ------------------------------------------------------------ BRAF_Mmus_RAF ------------------------------------------SAT--------------- ARAF_Mmus_RAF ------------------------------------------DGA--------------- lin-45_Cele_RAF ----------GSLLSTQARHRPHFQSGHILSGARMNRLHPLVDCT--------------- ksr-2_Cele_RAF -------------------------------------------------NVHK------- ksr-1_Cele_KSR ------------------------------------------------------------ BRAF_Hsap_RAF ------------------------------------------SAT--------------- ARAF_Hsap_RAF ------------------------------------------DGT--------------- RAF1_Mmus_RAF ------------------------------------------------------------ KSR1_Spur_KSR -------------------------------------------------------FLDNN Raf_Spur_RAF ------------------------------------------VLT--------------- KSR2_Spur_KSR ------------------------------------------------------------ AqueK675_Aque_KSR ------------------------------------------------------------ AqueK676_Aque_KSR ------------------------------------------------------------ AqueK677_Aque_RAF NSTEGRSPMERRLHSSSERHRHRSLERRS-------------SSG--------------- AqueK678_Aque_RAF NSTEGRSPMERRLHSSSERHRHRSLERRS-------------SSG--------------- AqueK679_Aque_RAF ------------------------------------------------------------ RAF1_Hsap_RAF ---------------------------------------------------LSSSPN-N- KSR2_Hsap_KSR ---------LHPV----TSNP--------------------------------------- KSR1_Hsap_KSR ---------LPEA----ADGT--------------------------------------- phl_Dmel_RAF ---------------------PP-----------------------------LPHPCTD- ksr_Dmel_KSR TSNASTAATLTGSLVNSTTTTST----------------------------CSFFPR-K- KSR2_Mmus_KSR ---------LHPV----TSNT--------------------------------------- KSR1_Mmus_KSR ---------LSST----ADST--------------------------------------- BRAF_Mmus_RAF ---------------------PP-----------------------------ASLPG-S- ARAF_Mmus_RAF ---------------------PR----------------------------GSPSPA-S- lin-45_Cele_RAF ---------------------PL----------------------------GSNSPS-S- ksr-2_Cele_RAF ------------T-------------------------------------------R-K- ksr-1_Cele_KSR -----------------------------------------------------SMSG-N- BRAF_Hsap_RAF ---------------------PP-----------------------------ASLPG-S- ARAF_Hsap_RAF ---------------------PR----------------------------GSPSPA-S- RAF1_Mmus_RAF ---------------------------------------------------LSSSPN-N- KSR1_Spur_KSR -E-----------NVTSTSSD-----------------------------------R-T- Raf_Spur_RAF ---------------------PNSAVQDGVFDYDPTNIANGLASSLPNTRNLIHSPK-R- KSR2_Spur_KSR ----------------------------------------------------SPIPS-S- AqueK675_Aque_KSR ------------------------------------------------------------ AqueK676_Aque_KSR ---------------------------------------------------AQSLPN-LL AqueK677_Aque_RAF ---------------------DR----------------------------TSATPD-S- AqueK678_Aque_RAF ---------------------DR----------------------------TSATPD-S- AqueK679_Aque_RAF ------------------------------------------------------------ RAF1_Hsap_RAF --LSP------------------------------------------------------- KSR2_Hsap_KSR -----------------ILEG--------------------------------------- KSR1_Hsap_KSR -----------------RLDD--------------------------------------- phl_Dmel_RAF --HSN------------------------------------------------------- ksr_Dmel_KSR --LST-----------AGVDK----------------------------R---------- KSR2_Mmus_KSR -----------------ILEG--------------------------------------- KSR1_Mmus_KSR -----------------RLDD--------------------------------------- BRAF_Mmus_RAF --LTN------------------------------------------------------- ARAF_Mmus_RAF --VS-------------------------------------------------------- lin-45_Cele_RAF --TCS---SPPGGLIGQPTLGQ------SPNVSGSTTSSLVAAHLHTLPLTPPQS----- ksr-2_Cele_RAF --L--------------------------------------------------------- ksr-1_Cele_KSR --IES------------------------------------------------------- BRAF_Hsap_RAF --LTN------------------------------------------------------- ARAF_Hsap_RAF --VS-------------------------------------------------------- RAF1_Mmus_RAF --LSP------------------------------------------------------- KSR1_Spur_KSR --I--------------------------------------------------------- Raf_Spur_RAF --ESG------------------------------------------------------- KSR2_Spur_KSR --SRSRRHE-----------AW------AA------------------------------ AqueK675_Aque_KSR ------------------------------------------------------------ AqueK676_Aque_KSR MAERRQSRG-----------GGANGEGLYA------------------------------ AqueK677_Aque_RAF --MSP-----------SYSTGQ------SPL------------------QTPTGSKPPLQ AqueK678_Aque_RAF --MSP-----------SYSTGQ------SPL------------------QTPTGSKPPLQ AqueK679_Aque_RAF ------------------------------------------------------------ RAF1_Hsap_RAF --------------T-------------------------------------G-WSQPKT KSR2_Hsap_KSR --------------NPL-------------------------------------LQIEVE KSR1_Hsap_KSR --------------QPK-AD--------------------------------V-LEAHEA phl_Dmel_RAF --------------S-------------------------------------T-QASPTS ksr_Dmel_KSR --------------TPFTSE--------------------------------Y-TDTHKS KSR2_Mmus_KSR --------------NPL-------------------------------------LQIEVE KSR1_Mmus_KSR --------------QPK-TD--------------------------------V-LGVHEA BRAF_Mmus_RAF ----------------------------------------------------V-KALQKS ARAF_Mmus_RAF --------------S-------------------------------------G-RKSPHS lin-45_Cele_RAF -------------------------------------------------------APPQK ksr-2_Cele_RAF ------------------------------------------------------ISMTTS ksr-1_Cele_KSR ---------------------------------------------------EGTIVANHE BRAF_Hsap_RAF ----------------------------------------------------V-KALQKS ARAF_Hsap_RAF --------------S-------------------------------------G-RKSPHS RAF1_Mmus_RAF --------------T-------------------------------------G-WSQPKT KSR1_Spur_KSR -----------------TV------------------------------------DSHDT Raf_Spur_RAF ----------------------------------------------------S-HSSQPS KSR2_Spur_KSR --------------T----K--PAPTSTYMDCPAHGNCESGAETNLMMSLDGGSLVATWP AqueK675_Aque_KSR -------------------------------------------------------ATDSD AqueK676_Aque_KSR --------------T----SEDNLQSWYD-RKPSLSGTISTADSKT-STL-VGSIMEGSD AqueK677_Aque_RAF TSLSSGDSGLGGSRS-------------------------------------S-TSYSSS AqueK678_Aque_RAF TSLSSGDSGLGGSRS-------------------------------------S-TSYSSS AqueK679_Aque_RAF ------------------------------------------------------------ RAF1_Hsap_RAF PV---------PA-----Q-RERAP--VS-GT-QEK------------NK---------- KSR2_Hsap_KSR PT---------S-----EN-EEVH-DEAE-ES-EDDFEEMNLSLLSAR-S---------- KSR1_Hsap_KSR EA---------E-----EP-EAGK-SEAE-DD-EDEVDDLPSSRRPWRGP---------- phl_Dmel_RAF TL---------KH-----N-RPRAR---S-AD-ESN------------KN---------- ksr_Dmel_KSR ND---------S-----DK-TVSLSGSASTDSDRTPVRVDS-TEDGDS------------ KSR2_Mmus_KSR PT---------S-----EN-EESH-NEAE-ES-EDEFEEMNLSLLSAR-S---------- KSR1_Mmus_KSR EA---------E-----EP-EAGK-SEAE-DDEEDEVDDLPSSRRPWRGP---------- BRAF_Mmus_RAF -----------PG----PQ-RERKSSSSS-SS-EDR------------SR---------- ARAF_Mmus_RAF KL---------PS----EQ-RERK----S-LA-DEK------------KK---------- lin-45_Cele_RAF IS---------PG----FF-RNRSR--SP-GE-RLD------------AQ---------- ksr-2_Cele_RAF TL---------D-----DV-TTFN-SEIN-EE-MDE------------------------ ksr-1_Cele_KSR DS---------T-GSQEVD-SE--AAPSQ-EA-VDK------------FNKRADGGFTWE BRAF_Hsap_RAF -----------PG----PQ-RERKS--SS-SS-EDR------------NR---------- ARAF_Hsap_RAF KS---------PA----EQ-RERK----S-LA-DDK------------KK---------- RAF1_Mmus_RAF PV---------PA-----Q-RERAP--GS-GT-QEK------------NK---------- KSR1_Spur_KSR HD---------P------F-TD---SERTLPEQVEPVDEVS-DPEPNILL---------- Raf_Spur_RAF -----------PT----HQPRWKDVLPGS-DS-KD-------------NK---------- KSR2_Spur_KSR QDRKCNCCPHIPENNCNSN-DQM-VSDWT-EE-YRR------------SS---------- AqueK675_Aque_KSR VF---------S-DCYTDD-EE--EEEEE-DE-IEE------------VP---------- AqueK676_Aque_KSR DDD----------DSYADS-EGVGSSGGL-DE-PEV------------NK---------- AqueK677_Aque_RAF TL---------PS-----Q-RRRQR---T-SS-EDK------------RA---------- AqueK678_Aque_RAF TL---------PS-----Q-RRRQR---T-SS-EDK------------RA---------- AqueK679_Aque_RAF ------------------------------------------------------------ RAF1_Hsap_RAF ------I--------RP--R--GQRDSSYYWEIEASEVML---STRIGSGSFGTVYKGKW KSR2_Hsap_KSR ------F--------PR--KASQTSIFLQEWDIPFEQLEI---GELIGKGRFGQVYHGRW KSR1_Hsap_KSR ------I--------SR--KASQTSVYLQEWDIPFEQVEL---GEPIGQGRWGRVHRGRW phl_Dmel_RAF ------L--------LL--R--DAKSSEENWNILAEEILI---GPRIGSGSFGTVYRAHW ksr_Dmel_KSR ------G--------QW--R--QNSISLKEWDIPYGDLLL---LERIGQGRFGTVHRALW KSR2_Mmus_KSR ------F--------PR--KASQTSIFLQEWDIPFEQLEI---GELIGKGRFGQVYHGRW KSR1_Mmus_KSR ------I--------SR--KASQTSVYLQEWDIPFEQVEL---GEPIGQGRWGRVHRGRW BRAF_Mmus_RAF ------M--------KT--L--GRRDSSDDWEIPDGQITV---GQRIGSGSFGTVYKGKW ARAF_Mmus_RAF ------V--------KN--L--GYRDSGYYWEVPPSEVQL---LKRIGTGSFGTVFRGRW lin-45_Cele_RAF ------R--------PR--P--PQKPHHEDWEILPNEFII---QYKVGSGSFGTVYRGEF ksr-2_Cele_RAF -------------------E--TVLMTWEDVTIKLTDVDV---MTKIGDGRFGSVYFGGY ksr-1_Cele_KSR RHAWNMS--------TIRGP--NAQASWNEVTIQFETIEFDKQAPIIGRGRFGKVLRGFH BRAF_Hsap_RAF ------M--------KT--L--GRRDSSDDWEIPDGQITV---GQRIGSGSFGTVYKGKW ARAF_Hsap_RAF ------V--------KN--L--GYRDSGYYWEVPPSEVQL---LKRIGTGSFGTVFRGRW RAF1_Mmus_RAF ------I--------RP--R--GQRDSSYYWEIEASEVML---STRIGSGSFGTVYKGKW KSR1_Spur_KSR ------A--------TR--K--NSQKLLSEWDIPFEQLEI---LDLIGTGRFGAVH---- Raf_Spur_RAF ------IKPPTTLLGHR--R--TRRDSNDDWEIPTEEIRL---GSRIGAGSFGTVFSGQW KSR2_Spur_KSR ------L--------HY--E--AQKEGLSEWTIPHANLKY---GRCIEKGKLGSTYKGHW AqueK675_Aque_KSR ------L--------SV-----YLQGKWKEWMVGSEEIQL---YGEAASSCKETVQKGYW AqueK676_Aque_KSR ------Y--------RI--R--HRNSVVDEWIIPYNDLKL---LEKLGSGPVAEVYKGYW AqueK677_Aque_RAF ----------------K--V--KCKDSSDVWEIPYNEIEV---GERIGSGSFGTVYKGKW AqueK678_Aque_RAF ------L--------QK--V--KCKDSSDVWEIPYNEIEV---GERIGSGSFGTVYKGKW AqueK679_Aque_RAF --------------------------------FKFRQVT--ILKETLGNGAYGVVYKAKC . . . . RAF1_Hsap_RAF HGDVA-VKILKV------VDPTP--EQFQAFRNEV-AVLRKTRHVNILLFMGYM-TKD-- KSR2_Hsap_KSR HGEVA-IRLIDI------ERDNE--DQLKAFKREV-MAYRQTRHENVVLFMGACMSPP-- KSR1_Hsap_KSR HGEVA-IRLLEM------DGHNQ--DHLKLFKKEV-MNYRQTRHENVVLFMGACMNPP-- phl_Dmel_RAF HGPVA-VKTLNV------KTPSP--AQLQAFKNEV-AMLKKTRHCNILLFMGCV-SKP-- ksr_Dmel_KSR HGDVA-VKLLNE------DYLQDE-HMLETFRSEV-ANFKNTRHENLVLFMGACMNPP-- KSR2_Mmus_KSR HGEVA-IRLIDI------ERDNE--DQLKAFKREV-MAYRQTRHENVVLFMGACMSPP-- KSR1_Mmus_KSR HGEVA-IRLLEM------DGHNQ--DHLKLFKKEV-MNYRQTRHENVVLFMGACMNPP-- BRAF_Mmus_RAF HGDVA-VKMLNV------TAPTP--QQLQAFKNEV-GVLRKTRHVNILLFMGYS-TKP-- ARAF_Mmus_RAF HGDVA-VKVLKV------AQPTA--EQAQAFKNEM-QVLRKTRHVNILLFMGFM-TRP-- lin-45_Cele_RAF FGTVA-IKKLNV------VDPTP--SQMAAFKNEV-AVLKKTRHLNVLLFMGWV-REP-- ksr-2_Cele_RAF HGNAA-VRFVNM------NYLSQEDRRADVFATEIVSAYKNSRHDHIALFYGYV-SDPVT ksr-1_Cele_KSR YGDVA-VKVYTM------EHISDASKKAEEFKLEV-SAYKNTRHDNIALFLGYFMSDG-- BRAF_Hsap_RAF HGDVA-VKMLNV------TAPTP--QQLQAFKNEV-GVLRKTRHVNILLFMGYS-TKP-- ARAF_Hsap_RAF HGDVA-VKVLKV------SQPTA--EQAQAFKNEM-QVLRKTRHVNILLFMGFM-TRP-- RAF1_Mmus_RAF HGDVA-VKILKV------VDPTP--EQLQAFRNEV-AVLRKTRHVNILLFMGYM-TKD-- KSR1_Spur_KSR ------------------------------------------------------------ Raf_Spur_RAF HGSVA-VKRLNV------KDPTP--SQLQAFKNEV-AVLRKTRHANILLFMGCT-SKP-- KSR2_Spur_KSR HGEVL-IQTR---------YSKS--TDINDFLDEV-AMLSKIRHENIALFMGACVEPG-- AqueK675_Aque_KSR HGNVW-VHQRTI------K--RQ--EDVRSFANEV-NTLCCIRHENIQLFMGVCLDLPAG AqueK676_Aque_KSR HGEVA-VKRFVL------PNATP--KQINKFREEV-AVLKKIRHENLALFMGVCLTTP-- AqueK677_Aque_RAF HGPVA-VKKLNV------SNPTE--QQMQAFKNEV-AVLMKTRHANILLFMGWT-SKP-- AqueK678_Aque_RAF HGPVA-VKKLNV------SNPTE--QQMQAFKNEV-AVLMKTRHANILLFMGWT-SKP-- AqueK679_Aque_RAF DELICAAKYMHPIFFALSEDPAVNVVATDKFKKEC-QLLSRLKHPNIVQYLGTH-EVN-- RAF1_Hsap_RAF -NLAIVTQWC--EGS-SLYKHLHVQ-ET--KFQMFQLIDIARQTAQGMDYLHAKNIIHRD KSR2_Hsap_KSR -HLAIITSLC--KGR-TLYSVVRDA-KI--VLDVNKTRQIAQEIVKGMGYLHAKGILHKD KSR1_Hsap_KSR -HLAIITSFC--KGR-TLHSFVRDP-KT--SLDINKTRQIAQEIIKGMGYLHAKGIVHKD phl_Dmel_RAF -SLAIVTQWC--EGS-SLYKHVHVS-ET--KFKLNTLIDIGRQVAQGMDYLHAKNIIHRD ksr_Dmel_KSR -YLAIVTSLC--KGN-TLYTYIHQR-RE--KFAMNRTLLIAQQIAQGMGYLHAREIIHKD KSR2_Mmus_KSR -HLAIITSLC--KGR-TLYSVVRDA-KI--VLDVNKTRQIAQEIVKGMGYLHAKGILHKD KSR1_Mmus_KSR -HLAIITSFC--KGR-TLHSFVRDP-KT--SLDINKTRQIAQEIIKGMGYLHAKGIVHKD BRAF_Mmus_RAF -QLAIVTQWC--EGS-SLYHHLHII-ET--KFEMIKLIDIARQTAQGMDYLHAKSIIHRD ARAF_Mmus_RAF -GFAIITQWC--EGS-SLYHHLHVA-DT--RFDMVQLIDVARQTAQGMDYLHAKNIIHRD lin-45_Cele_RAF -EIAIITQWC--EGS-SLYRHIHVQ-EPRVEFEMGAIIDILKQVSLGMNYLHSKNIIHRD ksr-2_Cele_RAF NTYAIVTNFY--QHN-TLYHRIHEQLSE--DFDQSWTFQISLQICQAMSYLHKKKILHRD ksr-1_Cele_KSR -QYGMVMSLS--KGSQSLYTLLHVV-RE--KLDLATTRKIAQQICQAVSYLHTKKILHKD BRAF_Hsap_RAF -QLAIVTQWC--EGS-SLYHHLHII-ET--KFEMIKLIDIARQTAQGMDYLHAKSIIHRD ARAF_Hsap_RAF -GFAIITQWC--EGS-SLYHHLHVA-DT--RFDMVQLIDVARQTAQGMDYLHAKNIIHRD RAF1_Mmus_RAF -NLAIVTQWC--EGS-SLYKHLHVQ-ET--KFQMFQLIDIARQTAQGMDYLHAKNIIHRD KSR1_Spur_KSR -------NLC--KGQ-TLYTHIHLR-KD--RFNINRTIQIATQITQGMSYLHHKGIVHKD Raf_Spur_RAF -QLAIVTQWC--EGS-SLYKHLHVL-DT--KLVMHQLIDISRQTAQGMDYLHAKNIIHRD KSR2_Spur_KSR -NLAVVNSIH--KGP-SLYHHLHVQ-RR--KLQTSSKMDIARQIGQAMGYLQAKGIIVGH AqueK675_Aque_KSR DTFGIIMSEV--KGD-TLYNHIHKL-GH--NFTTPSKLKILRQISEGMEYLHAKGIQHGG AqueK676_Aque_KSR -NLAIITSYC--KGY-TLYKLLHYW-SE--AFSLERLANIGRQIAQAMGYLHARGIIHKG AqueK677_Aque_RAF -RLTIVTQWC--DGS-TLFSHIHVL-ED--RFEMYKIIDICRQTAQGVDYLHAKQIIHRD AqueK678_Aque_RAF -RLTIVTQWC--DGS-TLFSHIHVL-ED--RFEMYKIIDICRQTAQGVDYLHAKQIIHRD AqueK679_Aque_RAF -GIDTVVLLMELMDS-SLHAYLHAHVDS--PLPFHQEINISLDVARALDYLHVNNIHHRD :*. :: : : : .: **: . * RAF1_Hsap_RAF MKSNNIFLHE---GL-TVKIGDFGLATVKSRW---SGS--QQVEQ--PTGSVLWMAPEVI KSR2_Hsap_KSR LKSKNVFYDN---G--KVVITDFGLFSISGVLQAGR--REDKLRI--QNGWLCHLAPEII KSR1_Hsap_KSR LKSKNVFYDN---G--KVVITDFGLFGISGVVREGR--RENQLKL--SHDWLCYLAPEIV phl_Dmel_RAF LKSNNIFLHE---DL-SVKIGDFGLATAKTRW---SGE--KQANQ--PTGSILWMAPEVI ksr_Dmel_KSR LRTKNIFIEN---G--KVIITDFGLFSSTKLLYC-----DMGLGV--PHNWLCYLAPELI KSR2_Mmus_KSR LKSKNVFYDN---G--KVVITDFGLFSISGVLQAGR--RDDKLRI--QNGWLCHLAPEII KSR1_Mmus_KSR LKSKNVFYDN---G--KVVITDFGLFGISGVVREER--RENQLKL--SHDWLCYLAPEIV BRAF_Mmus_RAF LKSNNIFLHE---DL-TVKIGDFGLATVKSRW---SGS--HQFEQ--LSGSILWMAPEVI ARAF_Mmus_RAF LKSNNIFLHE---GL-TVKIGDFGLATVKTRW---SGA--QPLEQ--PSGSVLWMAAEVI lin-45_Cele_RAF LKTNNIFLMD---DMSTVKIGDFGLATVKTKWTV-NGG--QQQQQ--PTGSILWMAPEVI ksr-2_Cele_RAF LRTKNILLDN---PN-RVVVTDFALMKLERLEN-PR--RNCTLLI--PNHWIDYLSPEIA ksr-1_Cele_KSR LRSKNILLES---KN-KVVITDFGILSMKRLA-HP--KQ--KSGYLTSKFWTNYIAPELA BRAF_Hsap_RAF LKSNNIFLHE---DL-TVKIGDFGLATVKSRW---SGS--HQFEQ--LSGSILWMAPEVI ARAF_Hsap_RAF LKSNNIFLHE---GL-TVKIGDFGLATVKTRW---SGA--QPLEQ--PSGSVLWMAAEVI RAF1_Mmus_RAF MKSNNIFLHE---GL-TVKIGDFGLATVKSRW---SGS--QQVEQ--PTGSVLWMAPEVI KSR1_Spur_KSR LKSKNIFIEN---G--KVVLTDFALFSIGRLSKQKT--RKDSLVI--PDGWLCYLAPELI Raf_Spur_RAF LKSNNIFLHD---DL-TVKIGDFGLATVKSRW---SGS--QQFEQ--PSGSILWMAPEVI KSR2_Spur_KSR LSSRCVYLES---KV-KLSVTRVDTSDVTC-----QRA--SHACL--PRGKLQYLAPELL AqueK675_Aque_KSR LSSKLVTINH---RV-CISL-SF----------HN--TN--NRQLEG--CDLPYLTPEEI AqueK676_Aque_KSR LNTKNIFLEKRDQKE-KVIITDMGLSSLSSLLYDNTTSKGGVVTF--PRAQLYSLAPEII AqueK677_Aque_RAF LKSNNIFLHD---DM-TVKIGDFGLATVKTRW---DGN--EKVRQ--PTGSILWMAPEVI AqueK678_Aque_RAF LKSNNIFLHD---DM-TVKIGDFGLATVKTRW---DGN--EKVRQ--PTGSILWMAPEVI AqueK679_Aque_RAF LSAKNILMLG---DY-RAKVSDFGQSKLRNPNG---GF--SSNSP--CPGNILYMPPETL : :. : : . :..* RAF1_Hsap_RAF RMQ-----------DNNP--FSFQSDVYSYGIVLYELMTGELPYSHIN-----NRDQIIF KSR2_Hsap_KSR RQLSPDT-----EEDKLP--FSKHSDVFALGTIWYELHAREWPFKTQ------PAEAIIW KSR1_Hsap_KSR REMTPGK-----DEDQLP--FSKAADVYAFGTVWYELQARDWPLKNQ------AAEASIW phl_Dmel_RAF RMQ-----------ELNP--YSFQSDVYAFGIVMYELLAECLPYGHIS-----NKDQILF ksr_Dmel_KSR RALQPEKP----RGECLE--FTPYSDVYSFGTVWYELICGEFTFKDQ------PAESIIW KSR2_Mmus_KSR RQLSPDT-----EEDKLP--FSKHSDVFALGTIWYELHAREWPFKTQ------PAEAIIW KSR1_Mmus_KSR REMIPGR-----DEDQLP--FSKAADVYAFGTVWYELQARDWPFKHQ------PAEALIW BRAF_Mmus_RAF RMQ-----------DKNP--YSFQSDVYAFGIVLYELMTGQLPYSNIN-----NRDQIIF ARAF_Mmus_RAF RMQ-----------DPNP--YSFQSDVYAYGVVLYELMTGSLPYSHIG-----SRDQIIF lin-45_Cele_RAF RMQ-----------DDNP--YTPQSDVYSFGICMYEILSSHLPYSNIN-----NRDQILF ksr-2_Cele_RAF GNLMIDWRGDVLFQHELP--FSQESDVYSFGTIFFELLLRRMPTGCD------SWDQKLY ksr-1_Cele_KSR MAMRTEYDE--YECDDFP--FSENSDVYAFGCVWFEMLTGALPYAGEL------PHQILF BRAF_Hsap_RAF RMQ-----------DKNP--YSFQSDVYAFGIVLYELMTGQLPYSNIN-----NRDQIIF ARAF_Hsap_RAF RMQ-----------DPNP--YSFQSDVYAYGVVLYELMTGSLPYSHIG-----CRDQIIF RAF1_Mmus_RAF RMQ-----------DDNP--FSFQSDVYSYGIVLYELMAGELPYAHIN-----NRDQIIF KSR1_Spur_KSR TSLKINTDG--TQDMELP--FSEKSDVYSFGTIWYELLAGEWPFHKQ------PVETVIW Raf_Spur_RAF RMR-----------DTNP--YSFQSDVYAFGVVLFELVTQSLPYQNIK-----HKDQIIW KSR2_Spur_KSR AKARVVPPE---FITGNE--QTHSTDVYAFGTILFEIIAGRWPLQYAC------SESVIY AqueK675_Aque_KSR RSITQLSNG--YLFLPTK--PTPSTDIFAFGTIAYELTTLKLPFLNQS------LLDLIW AqueK676_Aque_KSR RKISPTPVV---QIDQEPYSYNYATDVYAFGTILYELITKRFPFSTDSLGFAYEFEVVIF AqueK677_Aque_RAF RME-----------EPDP--YTFYCDVYSFGVVVYELISGQLPYPHVQ-----DRDQILF AqueK678_Aque_RAF RME-----------EPDP--YTFYCDVYSFGVVVYELISGQLPYPHVQ-----DRDQILF AqueK679_Aque_RAF KVP---------------PDFAPTLDEFSFGIVTIQIMSRKDPKPSD-----LHRTG--S * :: * :: . RAF1_Hsap_RAF MVGRG--YASPDLSKLYKNC-----PKAMKRLVADCVKKVKEERPLFPQILSSIELLQHS KSR2_Hsap_KSR QMGTG--M-KPNLSQ--IGM-----GKEISDILLFCWAFEQEERPTFTKLMDMLEK---- KSR1_Hsap_KSR QIGSGEGM-KRVLTS--VSL-----GKEVSEILSACWAFDLQERPSFSLLMDMLEK---- phl_Dmel_RAF MVGRG--LLRPDMSQVRSDA-----PQALKRLAEDCIKYTPKDRPLFRPLLNMLENMLRT ksr_Dmel_KSR QVGRG--M-KQSLAN--LQS-----GRDVKDLLMLCWTYEKEHRPQFARLLSLLEH---- KSR2_Mmus_KSR QMGTG--M-KPNLSQ--IGM-----GKEISDILLFCWAFEQEERPTFTKLMDMLEK---- KSR1_Mmus_KSR QIGSGEGV-RRVLAS--VSL-----GKEVGEILSACWAFDLQERPSFSLLMDMLER---- BRAF_Mmus_RAF MVGRG--YLSPDLSKVRSNC-----PKAMKRLMAECLKKKRDERPLFPQILASIELLARS ARAF_Mmus_RAF MVGRG--YLSPDLSKIFSNC-----PKAMRRLLTDCLKFQREERPLFPQILATIELLQRS lin-45_Cele_RAF MVGRG--YLRPDRSKIRHDT-----PKSMLKLYDNCIMFDRNERPVFGEVLERLRDI--I ksr-2_Cele_RAF AKMCGQKAALQRLDAQLQKI-----DGKLHELLLECWSSQPEKRPSFQQIVKRITV---Q ksr-1_Cele_KSR AKTQG--IR-PVLPNV--KC-----TQELKELLVSCWNTAPQDRPTLTDINLKLTALP-K BRAF_Hsap_RAF MVGRG--YLSPDLSKVRSNC-----PKAMKRLMAECLKKKRDERPLFPQILASIELLARS ARAF_Hsap_RAF MVGRG--YLSPDLSKISSNC-----PKAMRRLLSDCLKFQREERPLFPQILATIELLQRS RAF1_Mmus_RAF MVGRG--YASPDLSRLYKNC-----PKAMKRLVADCVKKVKEERPLFPQILSSIELLQHS KSR1_Spur_KSR QVGKG--L-KQPLNH--LQA-----SRDVKEILMMCWSYSPDSRPIFQHIKKTILR---- Raf_Spur_RAF MVGRG--YLQPDLSKVRNDT-----PKALKRLITDCYALNRDERPLFPVVLAALESLARQ KSR2_Spur_KSR QTCSG--RR-DDFRNV--TC-----SSTMKNLIQECWSQNPNERPSFQDIVKELKKN-VS AqueK675_Aque_KSR SVGNN--GH-QSLKLL--P------RSCFRSVIHRCWSH--TRRTTFKDILSSIQDNT-S AqueK676_Aque_KSR LVGHG--HR-QPFK-G--ET-----PKKLKDIVWECWSHQPQDRPPFSDLQERLARLCRK AqueK677_Aque_RAF MVGRG--FLRPDPSSARKDT-----PKSFKQLCIKCCQFEKDDRPLFHQILADLESLSDS AqueK678_Aque_RAF MVGRG--FLRPDPSSARKDT-----PKSFKQLCIKCCQFEKDDRPLFHQVYNNLESLSDS AqueK679_Aque_RAF LIGTLV--EVPEIERRRDDIDSCDPSNPILGLSISCISNDPQERPPIERMCQLLSLLKNT . : * *. : : : RAF1_Hsap_RAF LP---------------------------------------------------------- KSR2_Hsap_KSR LP---------------------------------------------------------- KSR1_Hsap_KSR LP---------------------------------------------------------- phl_Dmel_RAF LP---------------------------------------------------------- ksr_Dmel_KSR LPKK-------------------------------------------------------- KSR2_Mmus_KSR LP---------------------------------------------------------- KSR1_Mmus_KSR LP---------------------------------------------------------- BRAF_Mmus_RAF LP---------------------------------------------------------- ARAF_Mmus_RAF LP---------------------------------------------------------- lin-45_Cele_RAF LP---------------------------------------------------------- ksr-2_Cele_RAF MPRKE------------------------------------------------------- ksr-1_Cele_KSR KP---------------------------------------------------------- BRAF_Hsap_RAF LP---------------------------------------------------------- ARAF_Hsap_RAF LP---------------------------------------------------------- RAF1_Mmus_RAF LP---------------------------------------------------------- KSR1_Spur_KSR LPKKK------------------------------------------------------- Raf_Spur_RAF LP---------------------------------------------------------- KSR2_Spur_KSR LG---------------------------------------------------------- AqueK675_Aque_KSR FPP--------------------------------------------------------- AqueK676_Aque_KSR HT---------------------------------------------------------- AqueK677_Aque_RAF MP---------------------------------------------------------- AqueK678_Aque_RAF MP---------------------------------------------------------- AqueK679_Aque_RAF -SQYKKSAMGLSSSSDEGKENVHPFEDYGEVLIVELNENDTHYSSKIDDLTRTIKDKENL RAF1_Hsap_RAF ------------------------------------------------------------ KSR2_Hsap_KSR ------------------------------------------------------------ KSR1_Hsap_KSR ------------------------------------------------------------ phl_Dmel_RAF ------------------------------------------------------------ ksr_Dmel_KSR ------------------------------------------------------------ KSR2_Mmus_KSR ------------------------------------------------------------ KSR1_Mmus_KSR ------------------------------------------------------------ BRAF_Mmus_RAF ------------------------------------------------------------ ARAF_Mmus_RAF ------------------------------------------------------------ lin-45_Cele_RAF ------------------------------------------------------------ ksr-2_Cele_RAF ------------------------------------------------------------ ksr-1_Cele_KSR ------------------------------------------------------------ BRAF_Hsap_RAF ------------------------------------------------------------ ARAF_Hsap_RAF ------------------------------------------------------------ RAF1_Mmus_RAF ------------------------------------------------------------ KSR1_Spur_KSR ------------------------------------------------------------ Raf_Spur_RAF ------------------------------------------------------------ KSR2_Spur_KSR ------------------------------------------------------------ AqueK675_Aque_KSR ------------------------------------------------------------ AqueK676_Aque_KSR ------------------------------------------------------------ AqueK677_Aque_RAF ------------------------------------------------------------ AqueK678_Aque_RAF ------------------------------------------------------------ AqueK679_Aque_RAF LKDQSNILELRNKQLLQKSNIIDKYKLQLEEKESEDAEADKKKSQLEIYNLELETKVSEL RAF1_Hsap_RAF --KINRSASE-------------------------------------------------- KSR2_Hsap_KSR --KRNRRLSH-------------------------------------------------- KSR1_Hsap_KSR --KLNRRLSH-------------------------------------------------- phl_Dmel_RAF --KIHRSASE-------------------------------------------------- ksr_Dmel_KSR --RLARSPSH-------------------------------------------------- KSR2_Mmus_KSR --KRNRRLSH-------------------------------------------------- KSR1_Mmus_KSR --KLNRRLSH-------------------------------------------------- BRAF_Mmus_RAF --KIHRSASE-------------------------------------------------- ARAF_Mmus_RAF --KIERSASE-------------------------------------------------- lin-45_Cele_RAF --KLTRSQSA-------------------------------------------------- ksr-2_Cele_RAF --------SN-------------------------------------------------- ksr-1_Cele_KSR --RVNRSPSF-------------------------------------------------- BRAF_Hsap_RAF --KIHRSASE-------------------------------------------------- ARAF_Hsap_RAF --KIERSASE-------------------------------------------------- RAF1_Mmus_RAF --KINRSASE-------------------------------------------------- KSR1_Spur_KSR --GLHRSPSH-------------------------------------------------- Raf_Spur_RAF --KIHRSASE-------------------------------------------------- KSR2_Spur_KSR --NMKHSLSE-------------------------------------------------- AqueK675_Aque_KSR --TRFSSTSL-------------------------------------------------- AqueK676_Aque_KSR --PITRSPSH-------------------------------------------------- AqueK677_Aque_RAF --KIKRSNSE-------------------------------------------------- AqueK678_Aque_RAF --KIKRSNSE-------------------------------------------------- AqueK679_Aque_RAF KDQLNRKESEVIEKEKQLMEKEEQLRRKEEAIVAQQVSSDERYSICVSELEQLRAELDHL * RAF1_Hsap_RAF -------------------------------PS--------------------------- KSR2_Hsap_KSR -------------------------------PG--------------------------- KSR1_Hsap_KSR -------------------------------PG--------------------------- phl_Dmel_RAF -------------------------------PN--------------------------- ksr_Dmel_KSR -------------------------------PV--------------------------- KSR2_Mmus_KSR -------------------------------PG--------------------------- KSR1_Mmus_KSR -------------------------------PG--------------------------- BRAF_Mmus_RAF -------------------------------PS--------------------------- ARAF_Mmus_RAF -------------------------------PS--------------------------- lin-45_Cele_RAF -------------------------------PN--------------------------- ksr-2_Cele_RAF -------------------------------KQ--------------------------- ksr-1_Cele_KSR -------------------------------PV--------------------------- BRAF_Hsap_RAF -------------------------------PS--------------------------- ARAF_Hsap_RAF -------------------------------PS--------------------------- RAF1_Mmus_RAF -------------------------------PS--------------------------- KSR1_Spur_KSR -------------------------------PL--------------------------- Raf_Spur_RAF -------------------------------PS--------------------------- KSR2_Spur_KSR -------------------------------PD--------------------------- AqueK675_Aque_KSR -------------------------------PL--------------------------- AqueK676_Aque_KSR -------------------------------PI--------------------------- AqueK677_Aque_RAF -------------------------------PT--------------------------- AqueK678_Aque_RAF -------------------------------PN--------------------------- AqueK679_Aque_RAF QAEQAAKTPDSPFSLEPPFLSQPVPFEDNKQPRIPKKPKQLDLKWQTRKQSPVAFQPQSS RAF1_Hsap_RAF ----------------------LHRAAH-T------------------------------ KSR2_Hsap_KSR ---------------------HFWKSA--------------------------------- KSR1_Hsap_KSR ---------------------HFWKSA-DI------------------------------ phl_Dmel_RAF ----------------------LTQSQLQN------------------------------ ksr_Dmel_KSR ---------------------NLSRSA--------------------------------- KSR2_Mmus_KSR ---------------------HFWKS---------------------------------- KSR1_Mmus_KSR ---------------------HFWKSA-DI------------------------------ BRAF_Mmus_RAF ----------------------LNRAGFQT------------------------------ ARAF_Mmus_RAF ----------------------LHRTQA-------------------------------- lin-45_Cele_RAF ---------------------VLHLDSQ-Y------------------------------ ksr-2_Cele_RAF ---------------------KRRSTA--------------------------------- ksr-1_Cele_KSR ---------------------MM-KSY--------------------------------- BRAF_Hsap_RAF ----------------------LNRAGFQT------------------------------ ARAF_Hsap_RAF ----------------------LHRTQA-------------------------------- RAF1_Mmus_RAF ----------------------LHRAAH-T------------------------------ KSR1_Spur_KSR ---------------------HLSRSA--------------------------------- Raf_Spur_RAF ---------------------SLNRARLHS------------------------------ KSR2_Spur_KSR ---------------------NLNRLGT-------------------------------- AqueK675_Aque_KSR ---------------------SS-QHC--------------------------------- AqueK676_Aque_KSR ---------------------NLSKSVD-------------------------------- AqueK677_Aque_RAF ---------------------TLCYAGLSY------------------------------ AqueK678_Aque_RAF ---------------------LI-KQNIQN------------------------------ AqueK679_Aque_RAF MAVACMDKIYITYCNYSRSEGKIYEYSLSTDTWTQLPLLRKSEFSLAVVNNDYIVAVGGS RAF1_Hsap_RAF --------------------EDIN------------------------------------ KSR2_Hsap_KSR ------------------------------------------------------------ KSR1_Hsap_KSR -----------------------N------------------------------------ phl_Dmel_RAF --------------------DEF------------------------------------- ksr_Dmel_KSR ------------------------------------------------------------ KSR2_Mmus_KSR ------------------------------------------------------------ KSR1_Mmus_KSR -----------------------N------------------------------------ BRAF_Mmus_RAF --------------------EDFS------------------------------------ ARAF_Mmus_RAF --------------------DELP------------------------------------ lin-45_Cele_RAF --------------------SVMDAVMRSQMLSWS------------------------- ksr-2_Cele_RAF ------------------------------------------------------------ ksr-1_Cele_KSR ------------------------------------------------------------ BRAF_Hsap_RAF --------------------EDFS------------------------------------ ARAF_Hsap_RAF --------------------DELP------------------------------------ RAF1_Mmus_RAF --------------------EDIN------------------------------------ KSR1_Spur_KSR ------------------------------------------------------------ Raf_Spur_RAF --------------------DDFM------------------------------------ KSR2_Spur_KSR ------------------------------------------------------------ AqueK675_Aque_KSR ------------------------------------------------------------ AqueK676_Aque_KSR ------------------------------------------------------------ AqueK677_Aque_RAF --------------------QEE------------------------------------- AqueK678_Aque_RAF --------------------QKY------------------------------------- AqueK679_Aque_RAF AALRKSGSILKYLSASSKWVKEFP-DMPTPRSFPSCVTVGNYLVVAGGEVNSEPVPVVEI RAF1_Hsap_RAF ------------------------------------------------------------ KSR2_Hsap_KSR ------------------------------------------------------------ KSR1_Hsap_KSR ------------------------------------------------------------ phl_Dmel_RAF ------------------------------------------------------------ ksr_Dmel_KSR ------------------------------------------------------------ KSR2_Mmus_KSR ------------------------------------------------------------ KSR1_Mmus_KSR ------------------------------------------------------------ BRAF_Mmus_RAF ------------------------------------------------------------ ARAF_Mmus_RAF ------------------------------------------------------------ lin-45_Cele_RAF ------------------------------------------------------------ ksr-2_Cele_RAF ------------------------------------------------------------ ksr-1_Cele_KSR ------------------------------------------------------------ BRAF_Hsap_RAF ------------------------------------------------------------ ARAF_Hsap_RAF ------------------------------------------------------------ RAF1_Mmus_RAF ------------------------------------------------------------ KSR1_Spur_KSR ------------------------------------------------------------ Raf_Spur_RAF ------------------------------------------------------------ KSR2_Spur_KSR ------------------------------------------------------------ AqueK675_Aque_KSR ------------------------------------------------------------ AqueK676_Aque_KSR ------------------------------------------------------------ AqueK677_Aque_RAF ------------------------------------------------------------ AqueK678_Aque_RAF ------------------------------------------------------------ AqueK679_Aque_RAF LDVTKMTWHFVLPFPTRNISRMTVSTDGTFAYFLGGFEEGSLSKLAYAVNVSRLIAETER RAF1_Hsap_RAF ------------------ACTLTT------------------------------------ KSR2_Hsap_KSR ------------------------------------------------------------ KSR1_Hsap_KSR ------------------S--SKVVPRFE-RF---------------------------- phl_Dmel_RAF -----------------LYLPSPKTPVNF-NN---------------------------- ksr_Dmel_KSR ------------------------------------------------------------ KSR2_Mmus_KSR ------------------------------------------------------------ KSR1_Mmus_KSR ------------------S--SKVMPRFE-RF---------------------------- BRAF_Mmus_RAF ----------------LYACASPKTPIQA-G----------------------------- ARAF_Mmus_RAF ------------------ACLLS------------------------------------- lin-45_Cele_RAF ----------------YIPPATAKTPQSA-AA---------------------------- ksr-2_Cele_RAF ------------------------------------------------------------ ksr-1_Cele_KSR ------------------------------------------------------------ BRAF_Hsap_RAF ----------------LYACASPKTPIQA-G----------------------------- ARAF_Hsap_RAF ------------------ACLLS------------------------------------- RAF1_Mmus_RAF ------------------ACTLTT------------------------------------ KSR1_Spur_KSR ------------------------------------------------------------ Raf_Spur_RAF ------------------YCPSPKTPIQS-QF---------------------------- KSR2_Spur_KSR ------------------------------------------------------------ AqueK675_Aque_KSR ------------------------------------------------------------ AqueK676_Aque_KSR ------------------------------------------------------------ AqueK677_Aque_RAF ----------------L--NKSPHTPSHN-SS---------------------------- AqueK678_Aque_RAF ----------------L-PMPSYSTPV--------------------------------- AqueK679_Aque_RAF REGKKLWLELSSLPVSGATCASIRNRILALGGYDTMNKSSSDLIYEFDQIEGSWKPTGHL RAF1_Hsap_RAF ------------------------------------SPRLPVF KSR2_Hsap_KSR -----------------------------------------EL KSR1_Hsap_KSR ---------------------------GLG---V-LESSNPKM phl_Dmel_RAF ---------------------------F-Q-----FFGSAGNI ksr_Dmel_KSR ---------------------------------------ESVF KSR2_Mmus_KSR -----------------------------------------AE KSR1_Mmus_KSR ---------------------------GLG---T-LESGNPKM BRAF_Mmus_RAF -----------------------------------GYGGFPVH ARAF_Mmus_RAF ------------------------------------A-ARLVP lin-45_Cele_RAF ---------------------------AAAANKKAYYNVYGLI ksr-2_Cele_RAF -------------------------------------HENPLF ksr-1_Cele_KSR ---------------------------------------ESTF BRAF_Hsap_RAF -----------------------------------GYGAFPVH ARAF_Hsap_RAF ------------------------------------A-ARLVP RAF1_Mmus_RAF ------------------------------------SPRLPVF KSR1_Spur_KSR ---------------------------------------ESVL Raf_Spur_RAF ---------------------------A-------VFPFDMRG KSR2_Spur_KSR ---------------------------------------GLFR AqueK675_Aque_KSR ---------------------------------------TLRQ AqueK676_Aque_KSR --------------------------------------NLLHI AqueK677_Aque_RAF ---------------------------ATG---AESAFHLVKQ AqueK678_Aque_RAF ------------------------------------SFLNFSF AqueK679_Aque_RAF PRPFTRGLVAVATYESRKLLVVIGGNMTNN---ISTATNIAYL