CLUSTAL W (1.83) multiple sequence alignment MOK_Hsap_MOK M----------------------------------------------------------- MAK_Hsap_MAK ------------------------------------------------------------ ICK_Hsap_MAK ------------------------------------------------------------ CG4588_Dmel_MAK ------------------------------------------------------------ MOK_Mmus_MOK M----------------------------------------------------------- MAK_Mmus_MAK ------------------------------------------------------------ ICK_Mmus_MAK ------------------------------------------------------------ M04C9.5_Cele_MAK MTPRIRRKTNI------AS----FRIFHISGDYILCIVMSIYFL-------L--S----- IME2_Scer_MAK MVEKRSRQSS--------------------------------------------SS---- DDB0229430_Ddis_MAK ------------------------------------------------------------ 13065_Tthe MN---------------------------------------------------------- 15513_Tthe M----------------------------------------------------------- 26702_Tthe M----------------------------------------------------------- 27248_Tthe M----------------------------------------------------------- 28968_Tthe M----------------------------------------------------------- 7690_Tthe M----------------------------------------------------------- 9133_Tthe M----------------------------------------------------------- 9821_Tthe M----------------------------------------------------------- MAK_Spur_MAK M----------------------------------------------------------- MOK_Spur_MOK ------------------------------------------------------------ CC1G_11298_Ccin_MAK MYNNTNANPTRNRQPPLRETITVVGIPSVSID------NDRLVV---------GSS---- AqueK132_Aque_MAK MSV--------------------------------------------------------- AqueK133_Aque_MOK MPETLPL----------------------------------------------------- MAK_d_Smoe_MAK MHKTSI--------------------------------MQRYVL-------L-CFS---- MAK_c_Smoe_MAK MHKTSI--------------------------------MQRYVL-------LLCFT---- MAK_e_Smoe_MAK MQRYITKLSH---------------------------------------------S---- MAK_b_Smoe_MAK M----------------------------------------------------------- MAK_a_Smoe_MAK MQRYITKLSH---------------------------------------------S---- MOK_Smoe_MOK MRRTCDVRDR-----------------------------CRHVRHGSCDTGALSSSRAAF GK040_Glam_MOK MAEATTSAHE-------------------------------------------------- GK041_Glam_MAK M----------------------------------------------------------- GK039_Glam_MAK M----------------------------------------------------------- MOK_Hsap_MOK ----------------------------------------KNYKA--IGKIGEGTFSEVM MAK_Hsap_MAK ---------------------------------------MNRYTT--MRQLGDGTYGSVL ICK_Hsap_MAK ---------------------------------------MNRYTT--IRQLGDGTYGSVL CG4588_Dmel_MAK ---------------------------------------MNRYIT--LTQLGDGTYGTVV MOK_Mmus_MOK ----------------------------------------KNYKA--IGKIGEGTFSEVM MAK_Mmus_MAK ---------------------------------------MNRYTT--MKQLGDGTYGSVL ICK_Mmus_MAK ---------------------------------------MNRYTT--IKQLGDGTYGSVL M04C9.5_Cele_MAK ---------------------SK-------------TDNIFRYLM--TKRLGDGTFGEVM IME2_Scer_MAK -----GSEFSVPPDVDNPPLSIPL------------KTLSDRYQL--IEKLGAGSFGCVT DDB0229430_Ddis_MAK ---------------------------------------MEKYQF--IKQVGDGAYGDVI 13065_Tthe -----------------------------------------QYKL--LSKKGEGTFSEVL 15513_Tthe ----------------------------------------EKYIH--LDVIGKGSFGEVV 26702_Tthe ----------------------------------------DKYKI--TKNLGDGTYGTVV 27248_Tthe -------------------------------------------------TLGYHQYGSYY 28968_Tthe ----------------------------------------DKYQL--VKNLGDGTYGTVF 7690_Tthe ----------------------------------------KKYKI--GATLGDGTFGVVM 9133_Tthe ----------------------------------------DKYQI--SLQAHDNLYI-V- 9821_Tthe ----------------------------------------EKYNI--ISEIGRGAFGIVK MAK_Spur_MAK ----------------------------------------NQYQV--TKQLGDGTYGSVI MOK_Spur_MOK ------------------------------------------YRV--LGKKGEGTFSEVL CC1G_11298_Ccin_MAK -----Q------------------------------TSSTRSYTP--IKVLGDGSFGTVW AqueK132_Aque_MAK ---------------------------------------LQKYTF--LKVLGDGTFGVVS AqueK133_Aque_MOK ---------------------------------------VGDYRV--VGAMGEGTFSEVL MAK_d_Smoe_MAK -----GAN-------------SD-------------FVVLSRYKV--IKQLGDGTYGTVW MAK_c_Smoe_MAK -----GAN-------------SD-------------FVVLSRYKV--IKQLGDGTYGTVW MAK_e_Smoe_MAK -----QSF------------FLP-------------FFSFKRYQV--IKQVGDGTYGSVW MAK_b_Smoe_MAK ----------------------------------------TRYSIDYSTRLGRGTGGTVR MAK_a_Smoe_MAK -----QSF------------FLP-------------FFSFKRYQV--IKQVGDGTYGSVW MOK_Smoe_MOK SKCTVSSLF----------FFLPCSLASLFSSHCCGKMDSLEYRM--ICKKGEGTFSEVL GK040_Glam_MOK ------SK----------------------------SSSSHKYKF--VSKKGAGAFSDVI GK041_Glam_MAK ----------------------------------------ENYTV--ITELGSGNYGTVY GK039_Glam_MAK ----------------------------------------DAYTP--VRRVGSGTYGDVL MOK_Hsap_MOK KMQS-------------------------------LRDGNYYACKQMKQR--FE-SIEQV MAK_Hsap_MAK MGKS-------------------------------NESGELVAIKRMKRK--FY-SWDEC ICK_Hsap_MAK LGRS-------------------------------IESGELIAIKKMKRK--FY-SWEEC CG4588_Dmel_MAK LGQR-------------------------------KDTGEKVAIKRMKRK--YY-SWEEA MOK_Mmus_MOK KMQS-------------------------------LRDGNYYACKQMKQH--FE-SIEQV MAK_Mmus_MAK MGKS-------------------------------NESGELVAIKRMKRK--FY-SWDEC ICK_Mmus_MAK LGRS-------------------------------IESGELIAIKKMKRK--FY-SWEEC M04C9.5_Cele_MAK LAKK-------------------------------IDTGDRVAIKRMKKK--FY-SWEEA IME2_Scer_MAK LAKAQFPLSNILGKQHDIRGTLMDQPKNGHQNYI-TKTQGVVAIKTMMT--KLH-TLQDY DDB0229430_Ddis_MAK KAID-------------------------------VKTGEIVAIKRMKKK--FS-DWKEC 13065_Tthe KAQS-------------------------------LKEGKFVAIKCMKNH--FN-SIEQV 15513_Tthe KAQN-------------------------------KETKEIVAIKTMKQK--FV-TWEEC 26702_Tthe EAIN-------------------------------IEKNEKVAIKQMKQE--FK-SWEEC 27248_Tthe RAES-------------------------------LENGEMHLIEEHNKK--CS-TWEEC 28968_Tthe KAIN-------------------------------KENGEIVAIKKMKRK--YR-NWDEC 7690_Tthe KAVD-------------------------------ETNGQVVAIKKMKSK-KCP-KWEEI 9133_Tthe ---------------------------------L-NDQGKKLAMKKLKRGNTFA-DLEEA 9821_Tthe KAQN-------------------------------KETKEIVAIKQMLQE--YE-TWDEC MAK_Spur_MAK LGCR-------------------------------FDNGEKVAIKKMKKK--FY-SWNEC MOK_Spur_MOK KCQN-------------------------------IQDGTYYACKKMKQN--YQ-SLEQV CC1G_11298_Ccin_MAK LCDWHTTLP---------PNTPLSPMQCGQGARPEWAGKRLVAVKRMKKR--WEGGWDEC AqueK132_Aque_MAK LAKE-------------------------------KETGNMVAIKKMKQD--FL-SWEEC AqueK133_Aque_MOK KCQS-------------------------------LLDGKLYACKKMKQK--YS-NMTQV MAK_d_Smoe_MAK KAVN-------------------------------KVTNETVAIKKMKRK--YL-SWDEC MAK_c_Smoe_MAK KAVN-------------------------------KVTNETVAIKKMKRK--YL-SWDEC MAK_e_Smoe_MAK KAID-------------------------------RCTNEFVAIKKMKTK--FH-GWEEC MAK_b_Smoe_MAK EGIN-------------------------------LDTMEKVAIKEMVE--HLN-LHEET MAK_a_Smoe_MAK KAID-------------------------------RCTNEFVAIKKMKTK--FH-GWEEC MOK_Smoe_MOK KAQC-------------------------------HKSNKYVAIKCMKNT--FD-SLEQV GK040_Glam_MOK KAQC-------------------------------VKTEEYVAIKRMKAT--FK-SIEQI GK041_Glam_MAK KARE-------------------------------NKKGTLVAIKHMKQK--YK-SWSEC GK039_Glam_MAK HAVD-------------------------------T-KGDFVAIKIMNSH--TL-CVSDP : : MOK_Hsap_MOK NNLREIQ-------------------ALRRLNPHPNILMLHEVVFDRKSGSLALICELM- MAK_Hsap_MAK MNLREVK-------------------SLKKLN-HANVIKLKEVIR--ENDHLYFIFEYM- ICK_Hsap_MAK MNLREVK-------------------SLKKLN-HANVVKLKEVIR--ENDHLYFIFEYM- CG4588_Dmel_MAK MNLREVK-------------------SLKKLS-HPNIVKLKEVIR--ENDTLYFVFEYM- MOK_Mmus_MOK NSLREIQ-------------------ALRRLNPHPNILALHEVVFDRKSGSLALICELM- MAK_Mmus_MAK MNLREVK-------------------SLKKLN-HANVIKLKEVIR--ENDHLYFVFEYM- ICK_Mmus_MAK MNLREVK-------------------SLKKLN-HANIVKLKEVIR--ENDHLYFIFEYM- M04C9.5_Cele_MAK MSLREVK-------------------SLKKLN-HPNIIKLREVIR--ENDILYFVFEFM- IME2_Scer_MAK TRVREIK-------------------FILAIPANDHLIQIFEVFIDSENYQLHIVMECM- DDB0229430_Ddis_MAK IQLREIK-------------------ALKKLK-HPNIVKLLEIIL--ERDELFFVFEYL- 13065_Tthe QRLKEIQ-------------------ALRKVSPHPHIIKLIEVLYDEPTGRLALVFELM- 15513_Tthe MNLRELK-------------------SLRKLV-NKNIVKLKEVLR--VQNQLSFVFEYC- 26702_Tthe INLREIK-------------------SLRKLN-HPNIVKLREVLK--INNELYLVFEHM- 27248_Tthe ISIRQVK-------------------VLRVLN-HPNIIKIKEIIR--QDKQLFLVFEYF- 28968_Tthe MSLREVK-------------------SLRKMN-HPNLVKLKEVLQ--IKDELMLVFEYV- 7690_Tthe IKLPEIT-------------------SLMKFH-HPNIVNLYEIIK--HNNELFFVFEYM- 9133_Tthe KNDIEVR-------------------HLNKLK-NEHVIEVLDVIYNSTDRTGFIILPYF- 9821_Tthe INLRELK-------------------SLRKLT-HVNIIKLKEVFR--VKKQLSFVFEYV- MAK_Spur_MAK MELREVK-------------------SLKKLN-HANIVKLKEVIR--EDNILYFVFEYM- MOK_Spur_MOK NNLREIQ-------------------AMKRLSPHANILELKEVIFDRKTGNLSLVCELM- CC1G_11298_Ccin_MAK QKLKELE-------------------SLRAIPFHPNIIPLYDFFLLPTSKELYFVFESM- AqueK132_Aque_MAK LKLKEVQVSELFVSPYIYKYGRNDVHALQRLK-HVNIIKATEIFR--DNNTLYFVFEYM- AqueK133_Aque_MOK NNLREIQ-------------------ALRRLNPHPNVIELKEVIFDRQTGTLSLICELM- MAK_d_Smoe_MAK MNLREVK-------------------SLRKLN-HPNIVKLKEVIR--ENNELFFVFEYMV MAK_c_Smoe_MAK MNLREVK-------------------SLRKLN-HPNIVKLKEVIR--ENNELFFVFEYMV MAK_e_Smoe_MAK MNLREVK-------------------CLQRLD-HPNIVQLKEVIW--EHGELFLVFEYM- MAK_b_Smoe_MAK KLVY--G-------------------LLQECQ-HENIVKLLDVGS--IGGKTYMVFEHM- MAK_a_Smoe_MAK MNLREVK-------------------CLQRLD-HPNIVQLKEVIW--EHGELFLVFEYM- MOK_Smoe_MOK TNLREIQ-------------------ALQRLSPHTNVIKLLEVLYDQPTGRLALVFELM- GK040_Glam_MOK TSLREIQ-------------------SLRRLADQPFIIRLIEILFDRTTGRLALVFELM- GK041_Glam_MAK VTLKEVK-------------------SLIRMKEHPNIVKLMEVVR--QKEDLYFVFEYIN GK039_Glam_MAK LQLPEVA-------------------TLRRLPPHPNIIRLIRVVVT--RDHTHLIFEYA- : : :: . :: MOK_Hsap_MOK ---------------DMN-IYELIRG----RR-YPLSEK--------------------- MAK_Hsap_MAK ---------------KEN-LYQLMKD----RN-KLFPES--------------------- ICK_Hsap_MAK ---------------KEN-LYQLIKE----RN-KLFPES--------------------- CG4588_Dmel_MAK ---------------KEN-LYQMIKD----RD-THLPEP--------------------- MOK_Mmus_MOK ---------------DMN-IYELIRG----RR-HPLSEK--------------------- MAK_Mmus_MAK ---------------KEN-LYQLMKD----RN-KLFPES--------------------- ICK_Mmus_MAK ---------------KEN-LYQLIKE----RN-KLFPES--------------------- M04C9.5_Cele_MAK ---------------QEN-LYELMKD----RD-RYFPES--------------------- IME2_Scer_MAK ---------------EQN-LYQMMKHRR---R-RVFSIP--------------------- DDB0229430_Ddis_MAK ---------------ENN-LYESIKD----RT-KLLPET--------------------- 13065_Tthe ---------------DQN-LYEAIRG----KK-QYLNQQKLNKHIKGEKRPAYYLSQRIN 15513_Tthe ---------------DTD-IYKLYENQK-KLG-QRLPET--------------------- 26702_Tthe ---------------DIN-IYQYYLSFK-EKK-QKMPER--------------------- 27248_Tthe ---------------ETN-LSQYYQSFA-DSR-KKISEE--------------------- 28968_Tthe ---------------DLN-LYQMYMTYK-EKK-TQIPES--------------------- 7690_Tthe ---------------DQN-VYQMTKDR----E-KPFTEN--------------------- 9133_Tthe ---------------QMN-LFEFLENG----K-K-LQEF--------------------- 9821_Tthe ---------------EKN-IYKLYENAKQDGA-TSLPEN--------------------- MAK_Spur_MAK ---------------TEN-LYELMKG----RD-RLLPEP--------------------- MOK_Spur_MOK ---------------DMN-IYELIRG----RR-HYLPQE--------------------- CC1G_11298_Ccin_MAK ---------------EGN-LYHLIKA----RKGRPLAGG--------------------- AqueK132_Aque_MAK ---------------RQN-LYELIKS----RGSNLFPEH--------------------- AqueK133_Aque_MOK ---------------NMN-IYELIKD----RR-SYLPEA--------------------- MAK_d_Smoe_MAK LYFCFPFSATHFYLQECN-LYQMMKD----RQ-KLFPEA--------------------- MAK_c_Smoe_MAK LYFCFPFSATHVYLQECN-LYQMMKD----RQ-KLFPEA--------------------- MAK_e_Smoe_MAK ---------------ECN-LYQVMKD----RS-KMLSEE--------------------- MAK_b_Smoe_MAK ---------------FGD-LYKFKKRLGMLMK-RTLNRE--------------------- MAK_a_Smoe_MAK ---------------ECN-LYQVMKD----RS-KMLSEE--------------------- MOK_Smoe_MOK ---------------DMN-IYELIRG----RR-TYVSED--------------------- GK040_Glam_MOK ---------------EMN-LYELIKN----RK-YHLPES--------------------- GK041_Glam_MAK ---------------SGN-LFDFVVQQRS-A-GIKISEL--------------------- GK039_Glam_MAK ---------------GGGTLLNFLR-----SS-GPLKEH--------------------- . : . . MOK_Hsap_MOK -------------KIMHYMYQLCKSLDHIHRNGIFHRDVKPENILIKQ-D---------- MAK_Hsap_MAK -------------VIRNIMYQILQGLAFIHKHGFFHRDMKPENLLCMGPE---------- ICK_Hsap_MAK -------------AIRNIMYQILQGLAFIHKHGFFHRDLKPENLLCMGPE---------- CG4588_Dmel_MAK -------------ELKSILFQVLTGLAFMHRHGFFHRDLKPENLLCSGPD---------- MOK_Mmus_MOK -------------KIMLYMYQLCKSLDHMHRNGIFHRDVKPENILVKQ-D---------- MAK_Mmus_MAK -------------VIRNIMYQILQGLAFIHKHGFFHRDMKPENLLCMGPE---------- ICK_Mmus_MAK -------------AIRNIMYQILQGLAFIHKHGFFHRDLKPENLLCMGPE---------- M04C9.5_Cele_MAK -------------VIRNIIYQVLQGLAFMHKNGFFHRDMKPENIMCNGTE---------- IME2_Scer_MAK -------------SLKSILSQILAGLKHIHEHNFFHRDLKPENILITPSTQYFEKEYMNQ DDB0229430_Ddis_MAK -------------TIRNIIYQILQALHFMHTNGFFHRDLKPENIMLVG-E---------- 13065_Tthe NQKFDIFKVTIPISVKFYMYQLLKAIDHMHKKGIFHRDIKPENILLLG-D---------- 15513_Tthe -------------QLRSIFYQLAQSLSYMHKHGYFHRDLKPENILYSNKD---------- 26702_Tthe -------------VIKSIIFQTALGLAYMHKHGYFHRDLKPENLLISEDR---------- 27248_Tthe -------------QIKKIIYQIALALNQCHLNGIMHRDLSPENIYVTKQ----------- 28968_Tthe -------------VIKKIIYQIALGLDSLHNTGYFHRDLKPENLLVNMSS---------- 7690_Tthe -------------QIRNIIYQTLQGLAYIHRHGYFHRDLKPENLLESN------------ 9133_Tthe -------------QRRHIVKQLFQVLSFIHSQNIFHRDLHPENIMITDEQEYS------- 9821_Tthe -------------TIKSIVYQIASALSYMHKHGFFHRDLKPENLLISSD----------- MAK_Spur_MAK -------------VIRNIVYQILQGMAYIHKNGFFHRDMKPENLLCCGPE---------- MOK_Spur_MOK -------------KVKNYIYQLIKALEHMHRNGIFHRDVKPENILIRD-D---------- CC1G_11298_Ccin_MAK -------------LVSSIFQQITLGLDHIHTHGYFHRDMKPENVLVTTVGLF-DYTPVSP AqueK132_Aque_MAK -------------VVRNISYQIIQAVSYMHSQGLFHRDLKPENILCQGHE---------- AqueK133_Aque_MOK -------------RVRLYTYQLCKSLYHMHRNGIFHRDVKPENILIKD-D---------- MAK_d_Smoe_MAK -------------KIRNWCFQVLQGLAYMHREGYFHRDLKPENLLVTV-D---------- MAK_c_Smoe_MAK -------------KIRNWCFQVLQGLAYMHREGYFHRDLKPENLLVTV-D---------- MAK_e_Smoe_MAK -------------RIRIWSFQVLRALDYMHQHGIFHRDLKPENLLVSD-E---------- MAK_b_Smoe_MAK -------------EIKTIIEQILQALAYMHEHGIVHQDIKTANVLINKEG---------- MAK_a_Smoe_MAK -------------RIRIWSFQVLRALDYMHQHGIFHRDLKP------------------- MOK_Smoe_MOK -------------RIKSYMFQLLKAMDHMHRNGIFHRDIKPENILIME-E---------- GK040_Glam_MOK -------------SIKWYMWQLLHAVRIAHASGTFHRDIKPENILLDDKD---------- GK041_Glam_MAK -------------VAKDLVRQILEGLEHIHRNNYMHRDLKCENILVSDDGT--------- GK039_Glam_MAK -------------MLRNIAFRILQGLYHIHTNSVIHRDLKLENILLTSETGD-------- : : * . .*:*: MOK_Hsap_MOK --------------VLKLGDFGSCRSVYSKQPYTEYISTRWYRAPECLLTDG-FYTYKMD MAK_Hsap_MAK --------------LVKIADFGLARELRSQPPYTDYVSTRWYRAPEVLLRSS-VYSSPID ICK_Hsap_MAK --------------LVKIADFGLAREIRSKPPYTDYVSTRWYRAPEVLLRST-NYSSPID CG4588_Dmel_MAK --------------LIKIADFGLAREIRSRPPFTDYVSTRWYRAPEVLLHST-NYGSTID MOK_Mmus_MOK --------------VLKLGDFGSCRSVYSKQPYTEYISTRWYRAPECLLTDG-FYTYKMD MAK_Mmus_MAK --------------LVKIADFGLARELRSQPPYTDYVSTRWYRAPEVLLRSS-VYSSPID ICK_Mmus_MAK --------------LVKIADFGLAREIRSRPPYTDYVSTRWYRAPEVLLRST-NYSSPID M04C9.5_Cele_MAK --------------LVKIADFGLAREIRSKPPYTDYVSTRWYRAPEILLRST-SYNSPID IME2_Scer_MAK ------IG-YQDNYVIKLADFGLARHVENKNPYTAYVSTRWYRSPEILLRSG-YYSKPLD DDB0229430_Ddis_MAK --------------RLKIADFGLAREIESKPPFTDYISTRWYRAPEVLLRCT-YYNAPID 13065_Tthe --------------HVKLADFGSCKGIYSEHPYTEYISTRWYRAPECLLTDG-YYSSKMD 15513_Tthe -------------GYVKLTDFGLAREIRSRPPYTDYVATRWYRAPELILRAT-NYNSPVD 26702_Tthe -------------QVLKICDFGLAREIRSRPPYTDYVSTRWYRAPELLLKST-TYNSPVD 27248_Tthe -------------NRIKVGQFSNA-EFQNKHNNTAYVTSRYYESPESILKQQ--QNTKID 28968_Tthe -------------LNVKVCDFGLAREVRCRPPFTEYVSTRWYRAPEILLHSQ-NYNSPID 7690_Tthe -------------NTIKIADFGLAREIRSKPPFTDYVSTRWYRAPEVILRAN-NYNSPID 9133_Tthe -------S-DKSLFNIKLIDFGSSK-CRQDNQFTDYVGVRWYRAPELLLSCQ-KYDEKVD 9821_Tthe -------------GIVKLIDFGLAREVRSRPPYTDYVSTRWYRAPEILLRST-HYNSPVD MAK_Spur_MAK --------------LIKIADFGLARETRSRPPYTDYVSTRWYRAPEVLLRST-KYSSPID MOK_Spur_MOK --------------HLKLADFGSCRSVYSKQPFTEYISTRWYRAPECLLTDG-YYSYQMD CC1G_11298_Ccin_MAK IAPPNAPKERDVVTIIKLADFGLARETRSRPPYTEYVSTRWYRAPEVLLLSR-EYSNPVD AqueK132_Aque_MAK --------------LIKLADFGQAREIRSRPPYTDYVSTRWYRAPEVQLGSK-NYNSPID AqueK133_Aque_MOK --------------LLKLADFGSCKSMYSKLPFTEYISTRWYRAPECLLTDG-HYGHKMD MAK_d_Smoe_MAK --------------VIKIADFGLAREVRSRPPYTNYVSTRWYRAPEVLLQSS-LYNSAVD MAK_c_Smoe_MAK --------------VIKIADFGLAREVRSRPPYTNYVSTRWYRAPEVLLQSS-LYNSAVD MAK_e_Smoe_MAK --------------AIKVADFGLAREVYSVAPYTDYVATRWYRAPEVLLQAP-SYSYAID MAK_b_Smoe_MAK -------------TKVKLCDFDHARRVTTPPRDPETIGTLAYNAPEIILGDTQELGSGVD MAK_a_Smoe_MAK -----------------------------------------------------------D MOK_Smoe_MOK --------------SLKLADLGSCRGVYSKQPYTEYISTRWYRAPECLLTDG-YYNYKMD GK040_Glam_MOK --------------NLKLSDFGSCRGIHTQLPYTEYISTRWYRSPECLLTDG-VYGPEMD GK041_Glam_MAK -----------GTRCVKIADLGCAKSLLERPPHTVYVGTRWYRAVELFLKDS-SYSAKND GK039_Glam_MAK -------A-NGDIVGVKIADFGLSRAQGSRQ-NTDYVSTRWYRAPELLLHYS-GYGPPID * MOK_Hsap_MOK LWSAGCVFYEIASLQPLFPGVNELDQISKIHDVIGTPAQKI----------------LTK MAK_Hsap_MAK VWAVGSIMAELYMLRPLFPGTSEVDEIFKICQVLGTPKKSD----------------WPE ICK_Hsap_MAK VWAVGCIMAEVYTLRPLFPGASEIDTIFKICQVLGTPKKTD----------------WPE CG4588_Dmel_MAK LWAMGCIMAELYTFRPLFPGSSEVDQLFKICSVLGTPDKDD----------------WPD MOK_Mmus_MOK LWSAGCVFYEIASLQPLFPGVNELDQISKIHDVIGTPCQKT----------------LTK MAK_Mmus_MAK VWAVGSIMAELYTFRPLFPGTSEVDEIFKICQVLGTPKKSD----------------WPE ICK_Mmus_MAK IWAVGCIMAEVYTLRPLFPGASEIDTIFKICQVLGTPKKTD----------------WPE M04C9.5_Cele_MAK MWALGCIMAELYILRPLFPGTSEMDQLFKIISILGTPNKDE----------------WPE IME2_Scer_MAK IWAFGCVAVEVTVFRALFPGANEIDQIWKILEVLGTPIKRSDFVNTNHITAPPPGGFWDD DDB0229430_Ddis_MAK IWAVGAIMAELYSLKPMFPGSSEIDQLFKICTIMGSPTSAT----------------WID 13065_Tthe LWGVGCVMFEVMSLFPLFPGNDELDQAHKIHNVLGTPNPKI----------------LEQ 15513_Tthe IFALGCIMAELYMFKPLFNGSSELDQLQKMTSVLGTPSKLD----------------WPE 26702_Tthe IFALGCIMIELYMLNPLWAGASEIDHLYKMVETLGTPNQQT----------------WPD 27248_Tthe IWALGCIMGELYCLNPLFAGNSEIDQLMQILKIIGIPNHKE----------------YPE 28968_Tthe VFALGCIMAELYNLQPLFSGQNEVDQFYKIVSVLGTPQ--N----------------WNE 7690_Tthe IFAIGCIMAELYKLWPLFPGQNELDQILQICKVMGTPSKEE----------------WPE 9133_Tthe IFALGCIIYEIYHKKPLFPGTSELAQLNELCVILGSPTQEI----------------WSK 9821_Tthe IFALGCIMAELYLMKPLFNGSSEIDQIQKITSVLGTPQKQD----------------WPD MAK_Spur_MAK MWAVGCIMAELYTLRPLFPGSSEVDEIFKITTVLGTPKKEE----------------WVE MOK_Spur_MOK MWSVGCVFYEILSLHPLFPGANEVDQIAKIHDVMGTPDATI----------------LNK CC1G_11298_Ccin_MAK LWALGTIMAELVNLRPLFPGSDQVDQVARVCEVLGDPAEDYRDNGG-NVV---GGGQWPH AqueK132_Aque_MAK IWAVACIMSEVYSGRPLFPGSGTIDQVYKICGVLGTPTKAT----------------WGE AqueK133_Aque_MOK MWSVGCVLFELMSLRPLFPGSNELDQISKIHDVVGTPSSQV----------------LDK MAK_d_Smoe_MAK MWAMGAIMAELFNLRPIFPGASEADEIYKICSVLGNPSQAT----------------WPD MAK_c_Smoe_MAK MWAMGAIMAELFNLRPIFPGASEADEIYKICSVLGNPSQAT----------------WPD MAK_e_Smoe_MAK IWAMGAIMAELFNLQPLFPGASEADEIYKICSVLGSPNYHT----------------WPD MAK_b_Smoe_MAK VWGAGVILAELVLGYNPFSVVRESHAARELYRVVEEIKE--------------------- MAK_a_Smoe_MAK IWAMGAIMAELFNLQPLFPGASEADEIYKICSVLGSPNYHT----------------WPD MOK_Smoe_MOK MWGVGCVFFEIISLFPLFPGTNELDQIQKIHKVMGTPPQQL----------------LDK GK040_Glam_MOK LFGVGCVMFEITALFPLFPGKDELDQITRIHAILGTPPKEL----------------IQR GK041_Glam_MAK IWACACILCEILLMKPLFPGANDIDMLNLITSTLGSPTRED----------------WPA GK039_Glam_MAK IWAAGCCFAELLTGDPLFPGDTEIQQLQLICAFLK-PLKPD----------------ACK ::. . *: : : : MOK_Hsap_MOK F-KQ--SRAMNFD-FPFKK-GS---GIPL--------------L--TTNLS-PQCLSLLH MAK_Hsap_MAK GYQL--ASSMNFR-FPQCV-PI---NLKT--------------L--IPNAS-NEAIQLMT ICK_Hsap_MAK GYQL--SSAMNFR-WPQCV-PN---NLKT--------------L--IPNAS-SEAVQLLR CG4588_Dmel_MAK GYRL--ASMIHFR-YPDCI-KV---PLSS--------------V--VSRCS-QNGLDLLE MOK_Mmus_MOK F-KQ--SRAMSFD-FPFKK-GS---GIPL--------------L--TANLS-PQCLSLLH MAK_Mmus_MAK GYQL--ASSMNFR-FPQCI-PI---NLKT--------------L--IPNAS-SEAIQLMT ICK_Mmus_MAK GYQL--SSAMNFL-WPQCI-PN---NLKT--------------L--IPNAS-SEAIQLLR M04C9.5_Cele_MAK GYQL--ASAMNFR-FQQVV-AT---PMEQ--------------V--VNTIS-KEGMKLMM IME2_Scer_MAK ASNL--VHKLNLK-LPYVE-GS---SLDH--------------L--LSSSQLSDLSEVVK DDB0229430_Ddis_MAK GIKL--ANSMGFT-FPNVQ-PPSINPLST--------------L--LPNAN-QDAIELIT 13065_Tthe FQKH--ATHMELN-FPPKK-GT---GIEK--------------L--APHIP-KDCVDLIY 15513_Tthe GYRL--AGLKGIT-FPSYP-AI---PLNQ--------------V--ITDCP-YEAVQLIA 26702_Tthe GQKL--ANQTGIM-FPQKQEKV---PLQQ--------------Y--IPHAS-AEAVQLLE 27248_Tthe FHTL--CQQKQIKILPSHE-SM---KLPS--------------I--IPQAS-SEAIDLLF 28968_Tthe GAKL--AQKLQLT-IPKKE-PL---PLPQ--------------V--VPRAS-LDALQLLG 7690_Tthe GYKL--ASGVGYN-FPQYK-PQ---PLQE--------------L--IPNAS-PEAIDLLQ 9133_Tthe GVEQ--AEKKGLD-LGKHK-KS---NLKV--------------I--FCDMP-QDMVELCE 9821_Tthe GFIL--ASTKYYT-FPQYP-AI---PLSQ--------------V--IPNCP-PDALNLIS MAK_Spur_MAK GFRL--ASQMNFK-FPQCV-AM---PLKT--------------I--IPNAS-PESIHLIR MOK_Spur_MOK FRNK--ARGINYN-FPSKK-GS---GIEK--------------L--LPNAT-KQTLEIMN CC1G_11298_Ccin_MAK GVSL--ARDVGFQ-FPRIE-PK---DIFS--------------L--FDASVPRSLIQCIR AqueK132_Aque_MAK GVGL--AVSMSIR-LPIMV-PT---PLSA--------------L--VPTAS-DDGISVMK AqueK133_Aque_MOK FRKIQ-SKSMDFN-FPYKH-PT---GISI--------------L--LKHAS-KQCIDLIT MAK_d_Smoe_MAK GMKL--AKCMNFR-FPQ------------------------------------------- MAK_c_Smoe_MAK GMKL--AKCMNFR-FPQFV-PA---NLSA--------------L--VPSAS-AEAIDLMK MAK_e_Smoe_MAK GMQL--AVRKGFR-FPQFA-PA---GLQS--------------L--IPSAS-PAAVDMIS MAK_b_Smoe_MAK ----------------------------R--------------L--HREIGDEDILELLD MAK_a_Smoe_MAK GMQL--AVRKGFR-FPQFA-PA---GLQS--------------L--IPSAS-PAAVDMIS MOK_Smoe_MOK M----------------------------------------------------------- GK040_Glam_MOK IRKGAKNNPIKGD-FPPQK-GS---GLAK--------------L--IPHAS-STAIDLML GK041_Glam_MAK GYAL--AERIGYK-FPRAT-QSRQEKLRY--------------L--FPNVT-EDCINLLS GK039_Glam_MAK GAMHA---------LPRFI-TE---NMTVSDADIYTLAEAREALRRELGCS-HVLADLLA MOK_Hsap_MOK AMVAYDPDERIAAHQALQHPYFQEQRKTEKRAL---GS-HRKA--GFPE--HPV------ MAK_Hsap_MAK EMLNWDPKKRPTASQALKHPYFQVGQVLGPSSN---HLESKQSL-NKQL---Q--P---- ICK_Hsap_MAK DMLQWDPKKRPTASQALRYPYFQVGHPLGSTTQ---NLQDSEKP-QKGI---L-EK---- CG4588_Dmel_MAK DMLAYDPDKRPTAQQSLKYPYFHALKRISPTAA---TK-ANVRL-NSKY---A--A---- MOK_Mmus_MOK AMVAYDPDERIAAHQALQHPYFQVQRAAETQTL---AK-HRRA--FCPK--FSM------ MAK_Mmus_MAK EMLNWDPKKRPTASQALKHPYFQVGQVLGSSAH---HLDTKQTL-HKQL---Q--P---- ICK_Mmus_MAK DLLQWDPKKRPTASQALRYPYFQIGHPLGIISK---D---SGKP-QREV---Q-DK---- M04C9.5_Cele_MAK DMMLWNPEKRPNANQSLRYKYFQVAEKLGAPVV---SQPAPGSI-R-KT-----SA---- IME2_Scer_MAK KCLRWDPNERATAQELCEMPFFENTVASQVDAR-GNVTNTEQAL-IFAG----I------ DDB0229430_Ddis_MAK DLLQYDPLKRPTPLQALQHRYFKVSIPSSILLK---P--NFIEL-SNKY---L-IK---- 13065_Tthe KLLCYDPEERINAEQALQHPYFRDLYQMDQENQ---LLLQSTIT-SKTK----------- 15513_Tthe ECLKWDPQKRPTASKILQHQYFKGIESVLPTGY-F--NDQEEIK-VNQ-QQTIH------ 26702_Tthe MMLQYDPSKRPTAAQVLQHPYFIGLNNGSQNNS-S--TPVSSSN-L------GM------ 27248_Tthe KMLNINPSKRISIQAVLQHPFFSEINQKKLDQS-L--QKQQQYL-QNQS----------- 28968_Tthe DMLQYDPMKRPTAIQITKYPYFDDIRKENSDSG-SQ-VFSHSNL-QEAHSGNAL------ 7690_Tthe KMLRYSPQKRISAYAALQHPFFSCNI-PIPESI-K--MKNDKIL-QEGS---VL------ 9133_Tthe LCLTWNPEKRISAAEALNHKSII------------------------------------- 9821_Tthe EMLKWDPQKRITAAKILQHPYFSNVELPEELTA-E--SNSNQMI-QSSNQPATL------ MAK_Spur_MAK DMLLWDPQKRPTAAQCLKYKYFQVGQNLGAKAQ---PP-AQQHQ-QNQM---A-QR---- MOK_Spur_MOK KLCTYDPDERITAKQVIRHAFFKDLRDADKRKQ---HVEKKKLS-LGDQ--GSV------ CC1G_11298_Ccin_MAK DLLRWDPAKRLTSKQCLDHLYLRETIHRNNIPMPSGLRAASVSQTSIPMMSSHLNGSSSH AqueK132_Aque_MAK EMLQWNPRRRPTAKQVLMHKYFQVGHPYHTPSQ---VTSTTGHS-TKNT---L-TN---- AqueK133_Aque_MOK KLCTYDPEERPSAKETLRHPYFKELREAERRSK---LRLKSDV--MQPE--LSM------ MAK_d_Smoe_MAK AMFAWDPLKRPTPSQALQHPFFQVCSLSMFCTE---AIK--------------------- MAK_c_Smoe_MAK AMFAWDPLKRPTPSQALQHPFFQVCSLSMFCTE---AIK--------------------- MAK_e_Smoe_MAK AMLCWDPNRRPTAYQLRQHPFFYQFGLCIPPPI---ERPYVITI---------------- MAK_b_Smoe_MAK NMLVWEPEERWSAERALSSSFFEDGTRQMCGDP-Y------------------------- MAK_a_Smoe_MAK AMLCWDPNRRPTAYQLRQHPFFYQFGLCIPPPI---ERPYVITI---------------- MOK_Smoe_MOK ------------------------------------------------------------ GK040_Glam_MOK KLMEYDPQKRITAEEALRHPFFKDIGEIVRLKA---PTMPAGCL-EKLG--FTLDGRGAD GK041_Glam_MAK RMFEFDQNKRLSAQDCLRHPWFVNTCPTTAAAS---A--SSSFV-GTTG----V------ GK039_Glam_MAK HMLAWNPEDRITAQRALMHQFFA------------------------------------- MOK_Hsap_MOK ----------------------APEPLSNS-CQI-------------S--KEG-R----- MAK_Hsap_MAK ---------------------LESKPSLVE---V--EPKPLPDIIDQ---VVGQP----- ICK_Hsap_MAK ---------------------AGPPPYIKP---V--PPAQPPAKPHT---RISSR----- CG4588_Dmel_MAK ---------------------SNGHPVQSVSNNV--LPVQEKLQAV------T------- MOK_Mmus_MOK ----------------------VPESSSHN-WSF-------------S--QEG-R----- MAK_Mmus_MAK ---------------------LEPKPSSSE---R--DPKPLPNILDQ---PAGQP----- ICK_Mmus_MAK ---------------------TGPPPYIKP---A--PPAQAPAKAYT---LISSR----- M04C9.5_Cele_MAK ---------------------A--S-----------------VK--------SDT----- IME2_Scer_MAK ----------------------NPVATNTK-PIYFN-----------------SS----- DDB0229430_Ddis_MAK ----------------------NGYIN-NN-------INN--NSNYS---NNNNN----- 13065_Tthe ---------------------LSPSNNSNM-YNR-TLPENQLNLNQST--NNN-T----- 15513_Tthe ---------------------QGSS--NPN-NNDLNVS---------FGNEDS--SKQVK 26702_Tthe ---------------------QGASSSQPQ-ISIAD-S---------Y--EQN--LKKYE 27248_Tthe -----------------------DNKSR---NSFSSQS---------K--KQSS---RI- 28968_Tthe ---------------------TQ-QKSNHT-LSITNIPNK-------V--SENA-YKEIK 7690_Tthe ---------------------IDKRNFNDS--SV-------------K--NDNSQ----- 9133_Tthe ------------------------------------------------------------ 9821_Tthe ---------------------LGGASSNNA-ESVWNQS---------G--NNNANLNQFQ MAK_Spur_MAK ---------------------Q--APNQNS------------AKR-R---VLAES----- MOK_Spur_MOK ---------------------ISEDTAKES-HVE-------------G--KDG-D----- CC1G_11298_Ccin_MAK PSLSSHTPRNVPPSHSNSAHHVRPPPVP-------------------------------- AqueK132_Aque_MAK ------------------------TPNREK------ERENERGS--R---WQEDK----- AqueK133_Aque_MOK ----------------------KQQQHQH---KH-------------Y--KQG-R----- MAK_d_Smoe_MAK ------------------------------------------------------------ MAK_c_Smoe_MAK ------------------------------------------------------------ MAK_e_Smoe_MAK ------------------------------------DPDEQADYNYY---RRGQI----- MAK_b_Smoe_MAK ------------------------------------------------------------ MAK_a_Smoe_MAK ------------------------------------DPDEQADYNYY---RRGQI----- MOK_Smoe_MOK ------------------------------------------------------------ GK040_Glam_MOK AEDGTGARKATRERHGD---TVEGTPTPGD-LAV-------------T--EET-R----- GK041_Glam_MAK ---------------------GGDDASTEGL-SVA---------------RNA-L----- GK039_Glam_MAK ------------------------------------------------------------ MOK_Hsap_MOK ------------------------------------------------------------ MAK_Hsap_MAK ---QP----------KTSQQPLQPI----Q---------P--------------P-QN-- ICK_Hsap_MAK ---QH----------QASQPPLHLT----Y---------P--------------Y-KAE- CG4588_Dmel_MAK ----------------------ELL----H---------Q--------------T-NNN- MOK_Mmus_MOK ------------------------------------------------------------ MAK_Mmus_MAK ---QP----------KQGHQPLQTI----Q---------P--------------P-QN-- ICK_Mmus_MAK ---PS----------QASQPPQHSV----H---------P--------------Y-KGD- M04C9.5_Cele_MAK ---KA------------------------------------------------------- IME2_Scer_MAK -----------------TKLPAETE----------------------------------- DDB0229430_Ddis_MAK ---NN------------------------------------------------------- 13065_Tthe ------------------------------------------------------------ 15513_Tthe RNSFSMQNGQQQVLANKDNSPNNTNNNLGGPPLI-KKLSNQFSQSDASITNRLKGA---- 26702_Tthe ----K----------QQNSQPQGINNNL--------------------------YE---- 27248_Tthe ------------------QLPYNSQ----------------------------------- 28968_Tthe -----------------------------N------------------------------ 7690_Tthe ------------------------------------------------------------ 9133_Tthe ------------------------------------------------------------ 9821_Tthe GNVNAS-----------QNVPANS--RLGG-------------------------HSNTA MAK_Spur_MAK ---KP------------APSPLSKV----Q---------P--------------K-RDN- MOK_Spur_MOK ------------------------------------------------------------ CC1G_11298_Ccin_MAK -------------------SHFPEV----PPPQNSQPTP---------LPSV-------- AqueK132_Aque_MAK ---EG----------KRANQYLGGA----G---------P--------------Y-DRN- AqueK133_Aque_MOK ------------------------------------------------------------ MAK_d_Smoe_MAK --------------------PL-------------------------------------- MAK_c_Smoe_MAK --------------------PL-------------------------------------- MAK_e_Smoe_MAK ---HN----------TGYSQPLQEL----------------------------------- MAK_b_Smoe_MAK ------------------------------------------------------------ MAK_a_Smoe_MAK ---HN----------TGYSQPLQEL----------------------------------- MOK_Smoe_MOK ------------------------------------------------------------ GK040_Glam_MOK ------------------------------------------------------------ GK041_Glam_MAK ------------------------------------------------------------ GK039_Glam_MAK ------------------------------------------------------------ MOK_Hsap_MOK -----------------------------------------------------K-----Q MAK_Hsap_MAK -----------------------------------------------------LS----V ICK_Hsap_MAK -----------------------------------------------------VS----R CG4588_Dmel_MAK -----------------------------------------------------MNS---- MOK_Mmus_MOK -----------------------------------------------------K-----Q MAK_Mmus_MAK -----------------------------------------------------TV----T ICK_Mmus_MAK -----------------------------------------------------VS----R M04C9.5_Cele_MAK -----------------------------------------------------MTAKAAK IME2_Scer_MAK -------------------------------------------SNDIDISNNDHD----S DDB0229430_Ddis_MAK -----------------------------------------------------LNS---N 13065_Tthe -----------------------------------------------------NN----N 15513_Tthe NNFPH---------------------------SDYKSAKALELDSIAEISNNP------- 26702_Tthe NQIPH---------------------------ASYF------------VKT--------- 27248_Tthe -----------------------------------------------------TN----- 28968_Tthe ---------------------------------------------PWFVNN--QQ----S 7690_Tthe -----------------------------------------------------DQ----K 9133_Tthe ------------------------------------------------------------ 9821_Tthe NQNS-----------------------------SQFGLSSINSTSSYHLGNYNNH----Q MAK_Spur_MAK -----------------------------------------------------AQPKDSM MOK_Spur_MOK -----------------------------------------------------ND----N CC1G_11298_Ccin_MAK ---PHQPIPLHAQNGRRPHPIVGWTGPSPQPASD----------YPMD--TSP---SEP- AqueK132_Aque_MAK -----------------------------------------------------VS----G AqueK133_Aque_MOK -----------------------------------------------------GK----Q MAK_d_Smoe_MAK ------------------------------------------------------------ MAK_c_Smoe_MAK ------------------------------------------------------------ MAK_e_Smoe_MAK ------------------------------------------------------------ MAK_b_Smoe_MAK ------------------------------------------------------------ MAK_a_Smoe_MAK ------------------------------------------------------------ MOK_Smoe_MOK ------------------------------------------------------------ GK040_Glam_MOK -----------------------------------------------------S------ GK041_Glam_MAK ------------------------------------------------------------ GK039_Glam_MAK ------------------------------------------------------------ MOK_Hsap_MOK KQS--------------------------------------------------------- MAK_Hsap_MAK QQP-----------------P---KQ---------QSQ---------------------- ICK_Hsap_MAK TDH-----------------P---SH---------LQE---------------------- CG4588_Dmel_MAK --------------HSNLGKN---NN---------LAPKNGGVPRKYQPKLSFLTTSEMG MOK_Mmus_MOK KQS--------------------------------------------------------- MAK_Mmus_MAK HPP-----------------P---KQ---------QGH---------------------- ICK_Mmus_MAK TEQ-----------------L---SH---------VQE---------------------- M04C9.5_Cele_MAK KDY-----------I----GS---EN---------VSP---------------------- IME2_Scer_MAK HAM-CSPT---------------------------------------------------- DDB0229430_Ddis_MAK SEN-----------LN----NVNKNN---------QQP---------------------- 13065_Tthe HTN--------------------------------------------------------- 15513_Tthe -------------------------------SDPS-QG---------------------- 26702_Tthe -------------------------------------E---------------------- 27248_Tthe ------------------------------------------------------------ 28968_Tthe YQQ-QQSVLNENNFA-----KK--QNTQSYQSFNTLNL---------------------- 7690_Tthe RQE-I------------------------------------------------------- 9133_Tthe ------------------------------------------------------------ 9821_Tthe RQLSP---QTNYDNN-----SL--NTIKHGHGHFHYQS---------------------- MAK_Spur_MAK DDF-----------FANLGKS---KD---------VEP---------------------- MOK_Spur_MOK HKA--------------------------------------------------------- CC1G_11298_Ccin_MAK -----------Y----ANGH-ANNGH-SEHH----------------------------- AqueK132_Aque_MAK TK-----------------------K---------FEQ---------------------- AqueK133_Aque_MOK RER--------------------------------------------------------- MAK_d_Smoe_MAK ------------------------------------------------------------ MAK_c_Smoe_MAK ------------------------------------------------------------ MAK_e_Smoe_MAK ------------------------------------------------------------ MAK_b_Smoe_MAK ------------------------------------------------------------ MAK_a_Smoe_MAK ------------------------------------------------------------ MOK_Smoe_MOK ------------------------------------------------------------ GK040_Glam_MOK RQV--------------------------------------------------------- GK041_Glam_MAK Q----------------------------------------------------------- GK039_Glam_MAK ------------------------------------------------------------ MOK_Hsap_MOK ------------------------------------------------------------ MAK_Hsap_MAK ----------------------------------------------------EKP----- ICK_Hsap_MAK ----------------------------------------------------DKP----- CG4588_Dmel_MAK AGSHADSSSLVGGATVDGVPVPQHQNGGESINDIYLNRNISQLFGLPAGPQHQQQ----- MOK_Mmus_MOK ------------------------------------------------------------ MAK_Mmus_MAK ----------------------------------------------------QKP----- ICK_Mmus_MAK ----------------------------------------------------GKP----- M04C9.5_Cele_MAK ----------------------------------------------------QQP----- IME2_Scer_MAK -------------------------------------------------------LNQEK DDB0229430_Ddis_MAK ----------------------------------------------------HSP----- 13065_Tthe ------------------------------------------------------------ 15513_Tthe ----------------------------------------------------KPPLNPNK 26702_Tthe ----------------------------------------------------T-----EK 27248_Tthe ------------------------------------------------------------ 28968_Tthe ----------------------------------------------------SKPQ--NP 7690_Tthe ------------------------------------------------------------ 9133_Tthe ------------------------------------------------------------ 9821_Tthe ----------------------------------------------------SSPD--NR MAK_Spur_MAK ----------------------------------------------------SKP----- MOK_Spur_MOK ------------------------------------------------------------ CC1G_11298_Ccin_MAK ------------------------------------------------------------ AqueK132_Aque_MAK ----------------------------------------------------AKA----- AqueK133_Aque_MOK ------------------------------------------------------------ MAK_d_Smoe_MAK ------------------------------------------------------------ MAK_c_Smoe_MAK ------------------------------------------------------------ MAK_e_Smoe_MAK ------------------------------------------------------------ MAK_b_Smoe_MAK ------------------------------------------------------------ MAK_a_Smoe_MAK ------------------------------------------------------------ MOK_Smoe_MOK ------------------------------------------------------------ GK040_Glam_MOK ------------------------------------------------------------ GK041_Glam_MAK ------------------------------------------------------------ GK039_Glam_MAK ------------------------------------------------------------ MOK_Hsap_MOK ------------------------------------------------------------ MAK_Hsap_MAK PQT--------------------------------------------------------- ICK_Hsap_MAK SPL--------------------------------------------------------- CG4588_Dmel_MAK QQV---------------------HHPNVSFSTTSSRNAGAIYVNGSHLSYDTANMNAKN MOK_Mmus_MOK ------------------------------------------------------------ MAK_Mmus_MAK PQT--------------------------------------------------------- ICK_Mmus_MAK SPP--------------------------------------------------------- M04C9.5_Cele_MAK AKV--------------------------------------------------------- IME2_Scer_MAK ---LTLVEFLNEFVEEDNDDHSIPD----------------------------------- DDB0229430_Ddis_MAK QKI--------------------------------------------------------- 13065_Tthe ------STTRLEV----------------------------------------------- 15513_Tthe ---ISRQNNRNQVLKNQ--ENTTPS----------------------------------- 26702_Tthe ---VN-----RELYQQK--ENQNKI----------------------------------- 27248_Tthe ---TD-----DNF----------------------------------------------- 28968_Tthe FQQYK-----DEFLKNQ-------N----------------------------------- 7690_Tthe ------------------------------------------------------------ 9133_Tthe ------------------------------------------------------------ 9821_Tthe ---YT-----QSQFRSK-------N----------------------------------- MAK_Spur_MAK VQE--------------------------------------------------------- MOK_Spur_MOK ------------V----------------------------------------------- CC1G_11298_Ccin_MAK ------------------------------------------------------------ AqueK132_Aque_MAK EKG--------------------------------------------------------- AqueK133_Aque_MOK ----------DEF----------------------------------------------- MAK_d_Smoe_MAK ------------------------------------------------------------ MAK_c_Smoe_MAK ------------------------------------------------------------ MAK_e_Smoe_MAK --S--------------------------------------------------------- MAK_b_Smoe_MAK ------------------------------------------------------------ MAK_a_Smoe_MAK --S--------------------------------------------------------- MOK_Smoe_MOK ------------------------------------------------------------ GK040_Glam_MOK ------------------------------------------------------------ GK041_Glam_MAK ------------------------------------------------------------ GK039_Glam_MAK ------------------------------------------------------------ MOK_Hsap_MOK ------------------------------------------------------------ MAK_Hsap_MAK ----------------------LFPSIV---------------------KNMP----TKP ICK_Hsap_MAK ----------------------LFPSLH---------------------NKHPQ---SKI CG4588_Dmel_MAK NAKFVVGASNGGYYVPVARPSLLGPDAK---------------------VYNVF---SKV MOK_Mmus_MOK ------------------------------------------------------------ MAK_Mmus_MAK ----------------------MFPSII---------------------KTIP----VNS ICK_Mmus_MAK ----------------------FFPSLH---------------------NKNLQ---PKI M04C9.5_Cele_MAK ----------------------IDRHI--------------------------------- IME2_Scer_MAK ----------------------------VGTDS--------------------------- DDB0229430_Ddis_MAK ----------------------QTP----------------------------------- 13065_Tthe ------------------------------------------------------------ 15513_Tthe ----------------------------FNDRAKGKESGFNYSEFSNILDN--------- 26702_Tthe ----------------------------I---------------DDSLWNYTIN---NN- 27248_Tthe ------------------------------------------------------------ 28968_Tthe ----------------------IYSKQHV------------------------------- 7690_Tthe ------------------------------------------------------------ 9133_Tthe ------------------------------------------------------------ 9821_Tthe ----------------------------I---------------QY-------------- MAK_Spur_MAK ----------------------KAPNA--------------------------------- MOK_Spur_MOK ------------------------------------------------------------ CC1G_11298_Ccin_MAK --------PPAGHSMPPPKSLKLGPFGK---------------------K---------- AqueK132_Aque_MAK ----------------------GLPEVL---------------------KKSSGSYNNSP AqueK133_Aque_MOK ------------------------------------------------------------ MAK_d_Smoe_MAK ------------------------------------------------------------ MAK_c_Smoe_MAK ------------------------------------------------------------ MAK_e_Smoe_MAK ----------------------LFPSGK---------------------LR--------- MAK_b_Smoe_MAK ------------------------------------------------------------ MAK_a_Smoe_MAK ----------------------LFPSGK---------------------LR--------- MOK_Smoe_MOK ------------------------------------------------------------ GK040_Glam_MOK ------------------------------------------------------------ GK041_Glam_MAK ------------------------------------------------------------ GK039_Glam_MAK ------------------------------------------------------------ MOK_Hsap_MOK ------------------------------------------------------------ MAK_Hsap_MAK ---------NGTLSHKS-------GRRRWGQTIF--KSGDS----WEELE--DY-DFGAS ICK_Hsap_MAK ---------TAGLEHKNGEI-KPKSRRRWGLISRSTKDSDD----WADLD--DL-DFSPS CG4588_Dmel_MAK SASQAPPSLIVRQPQLQPEV-APAPMRLSGR-SRAAAAVQDPKMGALKSD--DL-DLILG MOK_Mmus_MOK ------------------------------------------------------------ MAK_Mmus_MAK ---------VSTLGHKG-------ARRRWGQTVF--KSGDS----CDDIE--D--DLGAS ICK_Mmus_MAK ---------LASLEQKNGEI-KPKSRRRWGLISRSTKGSDD----WADLD--DL-DFSPS M04C9.5_Cele_MAK --------------NR-------NLPLNKE-TL--------------------------- IME2_Scer_MAK ------------------------------------------------------------ DDB0229430_Ddis_MAK ------------------------------------------------------------ 13065_Tthe ------------------------------------------------------------ 15513_Tthe -------------RQQNNNSASKQQ----------------------------------- 26702_Tthe ---------TYNINNNNNNNNQNQQ----------------------------------- 27248_Tthe ------------------------------------------------------------ 28968_Tthe ---------------QDSNYAKRAA----------------------------------- 7690_Tthe ------------------------------------------------------------ 9133_Tthe ------------------------------------------------------------ 9821_Tthe -----------II--QNNRNNQRSQ----------------------------------- MAK_Spur_MAK -------------GNK-------SGRRKWE-TGK--KVEDS----WDDFDLEGSRGFGGT MOK_Spur_MOK ------------------------------------------------------------ CC1G_11298_Ccin_MAK -------------------------SSRWALGIFGSEKSHQ----LPPVD--EV-TTTAL AqueK132_Aque_MAK ---------LFGSHNANGGIVTQHQRKQWQ-TRSTAESGDS----GVDSE--GA-QFSNH AqueK133_Aque_MOK ------------------------------------------------------------ MAK_d_Smoe_MAK ------------------------------------------------------------ MAK_c_Smoe_MAK ------------------------------------------------------------ MAK_e_Smoe_MAK ------------------------------------------------------------ MAK_b_Smoe_MAK ------------------------------------------------------------ MAK_a_Smoe_MAK ------------------------------------------------------------ MOK_Smoe_MOK ------------------------------------------------------------ GK040_Glam_MOK ------------------------------------------------------------ GK041_Glam_MAK ------------------------------------------------------------ GK039_Glam_MAK ------------------------------------------------------------ MOK_Hsap_MOK ----------------------------------------------LKQE-EDR------ MAK_Hsap_MAK HSKK-----------------PSMGVFKEK----------------------------RK ICK_Hsap_MAK LSRI------------------DLK-NKKR----------------------------QS CG4588_Dmel_MAK SK-------------------LKTSA-KRQ----------------------------RN MOK_Mmus_MOK ----------------------------------------------LRHE-EGH------ MAK_Mmus_MAK HSKK-----------------PSMEACKEK-----------------------------K ICK_Mmus_MAK LTRI------------------DVK-NKKR----------------------------QS M04C9.5_Cele_MAK ------------------------------------------------------------ IME2_Scer_MAK -----------------------------------------TISDSIDET-ELSKEI-RN DDB0229430_Ddis_MAK ------------------------------------------------------------ 13065_Tthe --------------------------------------------SPQHNDPQYQ------ 15513_Tthe -----------------------------RATSLQQNNNDF------------------- 26702_Tthe ------------------------------------------------------------ 27248_Tthe ---------------------------------------------NIEQQ-QKTKSQQ-- 28968_Tthe --------------------------------------------NQLLYE-QQQSQQN-- 7690_Tthe --------------------------------------------QQIDKQ-QLLKNLK-- 9133_Tthe ------------------------------------------------------------ 9821_Tthe -------------------------------TDLIGLKNNFELNQQLQRQ-QQFSNQNQN MAK_Spur_MAK SAKTKKIGGM--KGK----ALPTIGAGNAV-----------------------------G MOK_Spur_MOK --------------------------------------------RKARRKSKLH------ CC1G_11298_Ccin_MAK GTR-KRSQSSSTDGKSVRDLSP-----ER-PQDL----------REVQK-QQKKEAER-- AqueK132_Aque_MAK FNSF-----------------PKY------------------------------------ AqueK133_Aque_MOK --------------------------------------------VPVKQR-QYY------ MAK_d_Smoe_MAK ------------------------------------------------------------ MAK_c_Smoe_MAK ------------------------------------------------------------ MAK_e_Smoe_MAK ------------------------------------------------------------ MAK_b_Smoe_MAK ------------------------------------------------------------ MAK_a_Smoe_MAK ------------------------------------------------------------ MOK_Smoe_MOK ------------------------------------------------------------ GK040_Glam_MOK ----------------------------------------------AKRP-QK------- GK041_Glam_MAK ------------------------------------------------RATRATDLNLDL GK039_Glam_MAK ------------------------------------------------------------ MOK_Hsap_MOK ------------------------------------------------------------ MAK_Hsap_MAK KD------SPFR-------------L----PE---PVPSGSN------------------ ICK_Hsap_MAK DD------TLCR-------------F----ES---VLDLKPS------------------ CG4588_Dmel_MAK AK------ANIL-------------L----ED---LFGQLSM------------------ MOK_Mmus_MOK ------------------------------------------------------------ MAK_Mmus_MAK KE------SPFR-------------F----PD---SGLPVSN------------------ ICK_Mmus_MAK DD------TLCR-------------F----ES---VLDLKPS------------------ M04C9.5_Cele_MAK ----------FE-------------------KSD-------N------------------ IME2_Scer_MAK NL------ALCQ-------------L----PD---------E-EVLD------------- DDB0229430_Ddis_MAK ------------------------------------------------------------ 13065_Tthe --SKN------------------------------------------------------- 15513_Tthe -------------------------FFGNHQQ---------NQNNNNISSSNNNN-TNNF 26702_Tthe ------------------------------------------NNNYNILTNNNGTRQNQF 27248_Tthe --SST------------------------------------------------------- 28968_Tthe --LNP------------------------------------------------------- 7690_Tthe --ASQ------------------------------------------------------- 9133_Tthe ------------------------------------------------------------ 9821_Tthe QISKKQFDPIYE-------------FLNN-----------------DVRTIN-------- MAK_Spur_MAK KK------ASLD-------------W----EDDDDFLKSPTK------------------ MOK_Spur_MOK --ESE------------------------------------------------------- CC1G_11298_Ccin_MAK --IN-------R--------------------EA--------------------EK---- AqueK132_Aque_MAK KG------PPLKPPAPVITSLVPPSK----PS---AVPLISS------------------ AqueK133_Aque_MOK --IPV------------------------------------------------------- MAK_d_Smoe_MAK ----------CR-------------W----V----------------------------- MAK_c_Smoe_MAK ----------CR-------------W----V----------------------------- MAK_e_Smoe_MAK ------------------------------------------------------------ MAK_b_Smoe_MAK ------------------------------------------------------------ MAK_a_Smoe_MAK ------------------------------------------------------------ MOK_Smoe_MOK ------------------------------------------------------------ GK040_Glam_MOK --TPP------------------------------------------------------- GK041_Glam_MAK LNGGNPYAHGDILPSYAQKKAKTTKELIELDHNDELHDNNMLDMIDDMF----------- GK039_Glam_MAK ------------------------------------------------------------ MOK_Hsap_MOK ---------------------------PKR-RG--------------------------- MAK_Hsap_MAK ------------HS-------T-------------------------------------- ICK_Hsap_MAK ------------EP-------V-------------------------------------- CG4588_Dmel_MAK ------------DS-------D-------------------------------------- MOK_Mmus_MOK ---------------------------ARR-QG--------------------------- MAK_Mmus_MAK ------------HF-------K-------------------------------------- ICK_Mmus_MAK ------------ES-------V-------------------------------------- M04C9.5_Cele_MAK ------------KP-------L-------------------------------------- IME2_Scer_MAK ------------H------------SL-SN--IRQLTNDIEII----------------- DDB0229430_Ddis_MAK ------------------------------------------------------------ 13065_Tthe ----L---------------------NTMK-IYS----QISGQ----------------- 15513_Tthe N------TS------------LTSP-S-GN-GNQ-------------------------- 26702_Tthe KQGGLGINSIKNPGFSNNFYSNEKP-T-NF------------------------------ 27248_Tthe -------------------------SNSFS-LIP----AVSAP----------------- 28968_Tthe ------------------------AST-TN--YH-------------------------- 7690_Tthe -------------------------SI-DN-LIN-------------------------- 9133_Tthe ------------------------------------------------------------ 9821_Tthe -----------NPN-------TGSIST-TN-NVN-------------------------- MAK_Spur_MAK ------------HR-------V-------------------------------------- MOK_Spur_MOK ----N---------------------YSST-LLP----KVQNN----------------- CC1G_11298_Ccin_MAK ---------------------------ERRKLAEKMAREQARAVMSKRNRMLREAVGEDI AqueK132_Aque_MAK ------------LF-------G-------------------------------------- AqueK133_Aque_MOK ----L---------------------ASQA-QGP----P---P----------------- MAK_d_Smoe_MAK ------------------------------------------------------------ MAK_c_Smoe_MAK ------------------------------------------------------------ MAK_e_Smoe_MAK ------------------------------------------------------------ MAK_b_Smoe_MAK ------------------------------------------------------------ MAK_a_Smoe_MAK ------------------------------------------------------------ MOK_Smoe_MOK ------------------------------------------------------------ GK040_Glam_MOK --------------------------GAKR-IGP----S---GV---------------- GK041_Glam_MAK ------------------------------------------------------------ GK039_Glam_MAK ------------------------------------------------------------ MOK_Hsap_MOK --------------------------------------PA-------------------- MAK_Hsap_MAK -------------------------GE------N------------KSLPA--------- ICK_Hsap_MAK -------------------------GT------G------------NSAPT--------- CG4588_Dmel_MAK -------------------------SDGK---YP------------HTVPPTQ------- MOK_Mmus_MOK --------------------------------------PT-------------------- MAK_Mmus_MAK -------------------------GE------N------------RNLHA--------- ICK_Mmus_MAK -------------------------GT------G------------TTVST--------- M04C9.5_Cele_MAK -------------------------GPTK------------------------------- IME2_Scer_MAK --------------------NKDEA---------DNME---------------------- DDB0229430_Ddis_MAK ------------------------------------------------------------ 13065_Tthe --------------------GG-QNN--------SSNSNL-------------------- 15513_Tthe --------------------------------------TIISSTSNNNIYN--------- 26702_Tthe ------------------------------------------------------------ 27248_Tthe --------------------QKTQE---------SSQSSLQNEQ---------------- 28968_Tthe --------------------------------------FASKSN---------------- 7690_Tthe --------------------------------------DLLQESQ--------------- 9133_Tthe ------------------------------------------------------------ 9821_Tthe --------------------------------------SIASNNNNNNN----------- MAK_Spur_MAK -------------------------GPLS----T------------RNQPG--------- MOK_Spur_MOK --------------------KM-VG---------HSISNY-------------------- CC1G_11298_Ccin_MAK DWSGGNQERVVDKGTKQASS-----GPI-----------------------RQKSMGNLG AqueK132_Aque_MAK -------------------------GQKRAVKRK------------DTLPTIDSFVGGDD AqueK133_Aque_MOK --------------------GV-H-G--------SMMSSL-------------------- MAK_d_Smoe_MAK ------------------------------------------------------------ MAK_c_Smoe_MAK ------------------------------------------------------------ MAK_e_Smoe_MAK ------------------------------------------------------------ MAK_b_Smoe_MAK ------------------------------------------------------------ MAK_a_Smoe_MAK ------------------------------------------------------------ MOK_Smoe_MOK ------------------------------------------------------------ GK040_Glam_MOK ---------------LQAGQGG-TNGL------LVSMGSL-------------------- GK041_Glam_MAK ------------------------------------------------------------ GK039_Glam_MAK ------------------------------------------------------------ MOK_Hsap_MOK ------------------------------------------------------------ MAK_Hsap_MAK ------------------------------------VTSL------------------K- ICK_Hsap_MAK ------------------------------------QTSY------------------Q- CG4588_Dmel_MAK ------------------------------------QAKS------------------G- MOK_Mmus_MOK ------------------------------------------------------------ MAK_Mmus_MAK ------------------------------------SVSL------------------K- ICK_Mmus_MAK ------------------------------------QASS------------------Q- M04C9.5_Cele_MAK ------------------------------------------------------------ IME2_Scer_MAK ------------------------------------------------------------ DDB0229430_Ddis_MAK ------------------------------------------------------------ 13065_Tthe ------------------------------------------------------------ 15513_Tthe ------------------------------------FANI------------------NM 26702_Tthe ------------------------------------------------------------ 27248_Tthe ------------------------------------------------------------ 28968_Tthe -----------------------------------------------------------L 7690_Tthe ------------------------------------------------------------ 9133_Tthe ------------------------------------------------------------ 9821_Tthe -----------------------------------------------------------N MAK_Spur_MAK ------------------------------------VARV------------------G- MOK_Spur_MOK ------------------------------------------------------------ CC1G_11298_Ccin_MAK NSTLHAASGKYSEPPAPPVSFDRYRDWRGTGERVAKARRREYDDDHSMS----------- AqueK132_Aque_MAK QS----RR----------------------GQFVAKETTGGRRDEGLDKFPFSWKSKVH- AqueK133_Aque_MOK ------------------------------------------------------------ MAK_d_Smoe_MAK ------------------------------------------------------------ MAK_c_Smoe_MAK ------------------------------------------------------------ MAK_e_Smoe_MAK ------------------------------------------------------------ MAK_b_Smoe_MAK ------------------------------------------------------------ MAK_a_Smoe_MAK ------------------------------------------------------------ MOK_Smoe_MOK ------------------------------------------------------------ GK040_Glam_MOK ------------------------------------------------------------ GK041_Glam_MAK ------------------------------------------------------------ GK039_Glam_MAK ------------------------------------------------------------ MOK_Hsap_MOK ----------------YVM---------------ELP----------------------- MAK_Hsap_MAK -------------------S--DS------------------------------------ ICK_Hsap_MAK -------------------R--RD------------------------------------ CG4588_Dmel_MAK -------------------K--TS------------------------------------ MOK_Mmus_MOK ----------------SLM---------------ELP----------------------- MAK_Mmus_MAK -------------------S--DP------------------------------------ ICK_Mmus_MAK -------------------R--RD------------------------------------ M04C9.5_Cele_MAK ------------------------------------------------------------ IME2_Scer_MAK ------------------------------------------------------QLFFDL DDB0229430_Ddis_MAK ------------------------------------------------------------ 13065_Tthe ------------------NTTTKYNPYRESAENVFYPVL----------------TIKKA 15513_Tthe NGRNQ---SPSPY-----------------------PYQNNNKQSNNNEFDQDKNDILGT 26702_Tthe --------SLNKY----------------------------------------------N 27248_Tthe ------------------------------------------------------------ 28968_Tthe NG------------------------------------------------------AQNS 7690_Tthe --------------------------------------------------------I--- 9133_Tthe ------------------------------------------------------------ 9821_Tthe NLGGQ---IINPLEKGSRF---------------SVPQGISSKNMIDDEIEDMEQEILGT MAK_Spur_MAK -------------------L--ES------------------------------------ MOK_Spur_MOK ------------------------------------PTQ----------------T---- CC1G_11298_Ccin_MAK ---SSDVHS-----------LS-------------------------------------- AqueK132_Aque_MAK -------------------V--SP------------------------------------ AqueK133_Aque_MOK ----------------TLP---------------QLPK---------------------- MAK_d_Smoe_MAK ------------------------------------------------------------ MAK_c_Smoe_MAK ------------------------------------------------------------ MAK_e_Smoe_MAK -------------------N--QQ------------------------------------ MAK_b_Smoe_MAK ------------------------------------------------------------ MAK_a_Smoe_MAK -------------------N--QQ------------------------------------ MOK_Smoe_MOK ------------------------------------------------------------ GK040_Glam_MOK ------------------T---------------QTNH---------------------- GK041_Glam_MAK ------------------------------------------------------------ GK039_Glam_MAK ------------------------------------------------------------ MOK_Hsap_MOK ---KL-KLSG-VVR-------LS---SYSS---PTLQSV--------------------- MAK_Hsap_MAK -ELST-APT-SKQYYLKQ--------SRYL---PGVN---PKKVSL-----IASG----- ICK_Hsap_MAK -TPTL-RSA-AKQHYLKH--------SRYL---PGIS---IRNGIL-----SNPG----- CG4588_Dmel_MAK -TGGH-GAG-ARERDLFG--------ESYL---PRPG---LRKKATQSSLEVNNG----- MOK_Mmus_MOK ---KL-RLSG-MTK-------LS---SCSS---PALRSV--------------------- MAK_Mmus_MAK -NLST-AST-AKQYYLKQ--------SRYL---PGVN---PKNVSL-----VAGG----- ICK_Mmus_MAK -TPTL-QSS-AKQHYLKH--------SRYL---PGIN---IRNGVL-----PNPG----- M04C9.5_Cele_MAK -SNEA-KPT-AKEIYLSK--------SKYV---PGTV----KNKFKK----SLKW----- IME2_Scer_MAK EIPEKDEFQR-KQP----------FNEH-------------------------------- DDB0229430_Ddis_MAK --------K-PKNSFLRK--------SRYS-YLNNVS---LEN----------VN----- 13065_Tthe TNPYH-KKKG-QQAAS----MKK-TQHQQY---PSFNL---------------------- 15513_Tthe Y----------------------------L---PSSINSG--G----------------- 26702_Tthe Y----------------------------Q---SQ-LSQ--------------------- 27248_Tthe DSPTNNHGKR-LSK----------FGMLSL---PKLSDL--------------------- 28968_Tthe G----------------------------L---PFGGTLE-------------------- 7690_Tthe ------------------------------------------------------------ 9133_Tthe ------------------------------------------------------------ 9821_Tthe Y----------------------------L---PTGGNVS-------------------- MAK_Spur_MAK -GKSS-ASS-AKQFYMGK--------ARYL---PGMN---VKSPRKD------------- MOK_Spur_MOK ------------------------FGSTSF---PKLHT---------------------- CC1G_11298_Ccin_MAK --------------------RVSS---ISFATV-----------------DSDPGPSRLR AqueK132_Aque_MAK -GVVD-KRE-ASNFYLTR--------ARYS---PIVS---GKVGF------GSG------ AqueK133_Aque_MOK -PPQL-QVKG-EQQVLH---GVNSGLSTGL---PSLAQS--------------------- MAK_d_Smoe_MAK ------------------------------------------------------------ MAK_c_Smoe_MAK ------------------------------------------------------------ MAK_e_Smoe_MAK -HSSL-A---SKAFSYGF--------PDVI---PCIK----------------------- MAK_b_Smoe_MAK ------------------------------------------------------------ MAK_a_Smoe_MAK -HSSL-A---SKAFSYGF--------PDVI---PCIK----------------------- MOK_Smoe_MOK ------------------------------------------------------------ GK040_Glam_MOK -PPKL-SDSKSTDNVLPHKHFQASEQEGSV---PKLPTLTR-T----------------- GK041_Glam_MAK ------------------------------------------------------------ GK039_Glam_MAK ------------------------------------------------------------ MOK_Hsap_MOK -----------------------------------------------------L------ MAK_Hsap_MAK --------------K-----------------------E-IN----PHTWSN-------- ICK_Hsap_MAK --------------K-----------------------EFIP----PNPWSS-------- CG4588_Dmel_MAK --------------S-----------------------H-AD----SLWWQV-------- MOK_Mmus_MOK -----------------------------------------------------L------ MAK_Mmus_MAK --------------K-----------------------D-IN----SHSWNN-------- ICK_Mmus_MAK --------------K-----------------------DFLP----SNSWSS-------- M04C9.5_Cele_MAK -------------LD-----------------------LLIP----YLNCQV-------- IME2_Scer_MAK ------------------------------------------------------------ DDB0229430_Ddis_MAK --------------NNNNNYNSNTTSGYYNQKLD-STPRLSP----RIVR---------- 13065_Tthe ------------------------------------------------------------ 15513_Tthe -----------------------------------------PNH---------QARGSYH 26702_Tthe -----------------------------------------------------QYGSSLH 27248_Tthe ------------------------------------------------------------ 28968_Tthe ------------------------------------------------------------ 7690_Tthe ------------------------------------------------------------ 9133_Tthe ------------------------------------------------------------ 9821_Tthe ------------------------------------------------------------ MAK_Spur_MAK -------------SG-----------------------HGLP----ALNKVP-------- MOK_Spur_MOK ------------------------------------------------------------ CC1G_11298_Ccin_MAK HHSSFHHAASSRTS-----------RSSLRTSFDDFSP----SARSSNSF---------- AqueK132_Aque_MAK ------------------------------------APRF--------NDPT-------- AqueK133_Aque_MOK -----------------------------------------------------M------ MAK_d_Smoe_MAK ------------------------------------------------------------ MAK_c_Smoe_MAK ------------------------------------------------------------ MAK_e_Smoe_MAK ------------------------------------------------------------ MAK_b_Smoe_MAK ------------------------------------------------------------ MAK_a_Smoe_MAK ------------------------------------------------------------ MOK_Smoe_MOK ------------------------------------------------------------ GK040_Glam_MOK -----------------------------------------PPARTNHGLTNVV------ GK041_Glam_MAK ------------------------------------------------------------ GK039_Glam_MAK ------------------------------------------------------------ MOK_Hsap_MOK ------G---------------------------SG-------T----NGRVPVL----- MAK_Hsap_MAK ------------Q-LFPKSLGPVGAELAFKRS----------------NAEESII----- ICK_Hsap_MAK ------------SGLSGK-------------S----------------SGTMSVI----- CG4588_Dmel_MAK ------------QGFG------------FISP----------------TGEVYMV----- MOK_Mmus_MOK ------G---------------------------TG-------A----NGKVPVL----- MAK_Mmus_MAK ------------Q-LFPKSLGSMGADLSFKRS----------------NAEDSII----- ICK_Mmus_MAK ------------SGLSGK-------------S----------------SGTVSVV----- M04C9.5_Cele_MAK ------------SK-----------------D----------------THQNQIM----- IME2_Scer_MAK -------------------------------ADID---------------EDIVL----- DDB0229430_Ddis_MAK -------------------------------Q-----------------QQQQIL----- 13065_Tthe ------NLKIESN------------------YKDSGTDEDADNN---NRSKPQFL----- 15513_Tthe NYSNTQPH---------------------------------------PRQ-QQQISSAIE 26702_Tthe NNQGIQQL---------------------------------------NQ--QGSL---PQ 27248_Tthe -----VPI---------------------------------------------------- 28968_Tthe -----RPLNFNNQ------------------YDLQK-------V---NRRQNNL------ 7690_Tthe ------------------------------------------------------------ 9133_Tthe ------------------------------------------------------------ 9821_Tthe ------------------------------------------------------------ MAK_Spur_MAK ------------SG-----------------S----------------AHRSNIL----- MOK_Spur_MOK ------N------------------------------------N---NRHQQSML----- CC1G_11298_Ccin_MAK --------------------------------SLEG-------SSSL------------- AqueK132_Aque_MAK ------------PS--PK------------------------------------------ AqueK133_Aque_MOK ------K---------------------------AG-------PSHIARHQQPHI----- MAK_d_Smoe_MAK ------------------------------------------------------------ MAK_c_Smoe_MAK ------------------------------------------------------------ MAK_e_Smoe_MAK ------------------------------------------------------------ MAK_b_Smoe_MAK ------------------------------------------------------------ MAK_a_Smoe_MAK ------------------------------------------------------------ MOK_Smoe_MOK ------------------------------------------------------------ GK040_Glam_MOK ------L---------------------------QG-------S----NSAQTKL----- GK041_Glam_MAK ------------------------------------------------------------ GK039_Glam_MAK ------------------------------------------------------------ MOK_Hsap_MOK -------------------------RP--------------------------------- MAK_Hsap_MAK -------------------------KP--------------------------------- ICK_Hsap_MAK -------------------------SK--------------------------------- CG4588_Dmel_MAK ------YGLHKAWVSERGIRFLSYHKL--------------------------------- MOK_Mmus_MOK -------------------------RP--------------------------------- MAK_Mmus_MAK -------------------------KP--------------------------------- ICK_Mmus_MAK -------------------------SK--------------------------------- M04C9.5_Cele_MAK -------------------------TT--------------------------------- IME2_Scer_MAK -------------------------PY--------------------------------- DDB0229430_Ddis_MAK -------------------------LP--------------------------------- 13065_Tthe -------------------------PP--------------------------------- 15513_Tthe KRSSNSI------------------PYNTINYNGNQSNANNSASIHNAFNGGIYQSSIET 26702_Tthe KQGKNMY----------------------------------------------------- 27248_Tthe ------------------------------------------------------------ 28968_Tthe ------------------------------------------------------------ 7690_Tthe ------------------------------------------------------------ 9133_Tthe ------------------------------------------------------------ 9821_Tthe ------------------------------------------------------------ MAK_Spur_MAK -------------------------GS--------------------------------- MOK_Spur_MOK -------------------------PS--------------------------------- CC1G_11298_Ccin_MAK ------------------------------------------------------------ AqueK132_Aque_MAK ------------------------------------------------------------ AqueK133_Aque_MOK -------------------------SP--------------------------------- MAK_d_Smoe_MAK ------------------------------------------------------------ MAK_c_Smoe_MAK ------------------------------------------------------------ MAK_e_Smoe_MAK -------------------------RP--------------------------------- MAK_b_Smoe_MAK ------------------------------------------------------------ MAK_a_Smoe_MAK -------------------------RP--------------------------------- MOK_Smoe_MOK ------------------------------------------------------------ GK040_Glam_MOK -------------------------GP--------------------------------- GK041_Glam_MAK ------------------------------------------------------------ GK039_Glam_MAK ------------------------------------------------------------ MOK_Hsap_MOK ----L-K-CI-PA-SKK------------------------------------------- MAK_Hsap_MAK ----I-E-KL-SCNETFPEKLED-----------PQGN---------------------L ICK_Hsap_MAK ----V-N-SV-GSS---------------------------------------------- CG4588_Dmel_MAK ----VTA-TM-GQD---------------------------------------------- MOK_Mmus_MOK ----L-K-CA-AV-NKK------------------------------------------- MAK_Mmus_MAK ----I-E-NL-SCTGKSAEQLED-----------PQGN---------------------L ICK_Mmus_MAK ----I-T-SV-GSG---------------------------------------------- M04C9.5_Cele_MAK ------N----------------------------------------------------- IME2_Scer_MAK ------------------------------------------------------------ DDB0229430_Ddis_MAK ----L-IIQ--------------------------------------------------- 13065_Tthe ----I-K-NQ-MN-PNHMMQMETKVN---------------------------------- 15513_Tthe GSRPT-R-NL-NS----AAYFENKTNTYNNQEYNSQSVNGSYRDYQNNNTNNVRNFYGNS 26702_Tthe ----K-N-N-----------------------------FAGNATW--------------- 27248_Tthe ------------------------------------------------------------ 28968_Tthe ------------------------------------------------------------ 7690_Tthe ------------------------------------------------------------ 9133_Tthe ------------------------------------------------------------ 9821_Tthe ---R-------------------------------------------------------- MAK_Spur_MAK ------N---------YARRTEN-----------NYG----------------------- MOK_Spur_MOK ----I-A-NT-HY-NKH------------------------------------------- CC1G_11298_Ccin_MAK ------------------------------------------------------------ AqueK132_Aque_MAK ----------------HSGSIRE-----------PN------------------------ AqueK133_Aque_MOK ----F-P-SL-LA-STN------------------------------------------- MAK_d_Smoe_MAK ------------------------------------------------------------ MAK_c_Smoe_MAK ------------------------------------------------------------ MAK_e_Smoe_MAK ----V-A-GL-GISSKHVCSGED------------------------------------- MAK_b_Smoe_MAK ------------------------------------------------------------ MAK_a_Smoe_MAK ----V-A-GL-GISSKHVCSGED------------------------------------- MOK_Smoe_MOK ------------------------------------------------------------ GK040_Glam_MOK ----QTK-QQLIF-TKQ------------------------------------------- GK041_Glam_MAK ------------------------------------------------------------ GK039_Glam_MAK ------------------------------------------------------------ MOK_Hsap_MOK ------------------------------------------------------------ MAK_Hsap_MAK ------------------------------------------------------------ ICK_Hsap_MAK ------------------------------------------------------------ CG4588_Dmel_MAK ------------------------------------------------------------ MOK_Mmus_MOK ------------------------------------------------------------ MAK_Mmus_MAK ------------------------------------------------------------ ICK_Mmus_MAK ------------------------------------------------------------ M04C9.5_Cele_MAK ------------------------------------------------------------ IME2_Scer_MAK ----------VN--N----------------------------------S---NYT---H DDB0229430_Ddis_MAK ------------------------------------------------------------ 13065_Tthe ------------------------------------------------------------ 15513_Tthe PSHFNDNSGYIP---SAALG-----------------------GSNTGNNYST------- 26702_Tthe -----NLSEYKNNNYNFQQGGVQNLGQSNHSS-------NYYNSQNPGQNYNTNI---NQ 27248_Tthe ----------SS--F----------------------------------S---QYS---Q 28968_Tthe ----------LKKNY----------------ENFNSIQSN------NE-P---QYF-NQQ 7690_Tthe ----------INNNL----------------E-----------------N---QFN-SQK 9133_Tthe ------------------------------------------------------------ 9821_Tthe ----------VRNSN---------------NN-------NTLSQNNNGST---LFGNNQE MAK_Spur_MAK ------------------------------------------------------------ MOK_Spur_MOK ------------------------------------------------------------ CC1G_11298_Ccin_MAK -------------------------------------AH--------------EFGA-HL AqueK132_Aque_MAK ------------------------------------------------------------ AqueK133_Aque_MOK ------------------------------------------------------------ MAK_d_Smoe_MAK ------------------------------------------------------------ MAK_c_Smoe_MAK ------------------------------------------------------------ MAK_e_Smoe_MAK ------------------------------------------------------------ MAK_b_Smoe_MAK ------------------------------------------------------------ MAK_a_Smoe_MAK ------------------------------------------------------------ MOK_Smoe_MOK ------------------------------------------------------------ GK040_Glam_MOK ------------------------------------------------------------ GK041_Glam_MAK ------------------------------------------------------------ GK039_Glam_MAK ------------------------------------------------------------ MOK_Hsap_MOK -----------------------------TD----------------------------- MAK_Hsap_MAK ---------------------G----SYATYNQS------------G------------- ICK_Hsap_MAK ---------------------S----TSSSGLTG------------N------------- CG4588_Dmel_MAK ---------------------S----SYKSGLSQALTHQSSALHRFS------------- MOK_Mmus_MOK -----------------------------TD----------------------------- MAK_Mmus_MAK ---------------------G----SYTTYNQT------------G------------- ICK_Mmus_MAK ---------------------S----ASSSGLTG------------S------------- M04C9.5_Cele_MAK ------------------------------GLTGT-----------T------------- IME2_Scer_MAK T---DRSHHRG--------DNVLGDAS--LGDSF------------N------------- DDB0229430_Ddis_MAK ----------------------------------------------Q-QPPPQ---SQPP 13065_Tthe -------MMKGQN-------------SVKQK----------------------------- 15513_Tthe ---NNTNN--------------IYSF---------------------------------- 26702_Tthe QQINLAQT--------------INNT-----NSN------------N------------- 27248_Tthe K----------------------------------------------------------- 28968_Tthe KYSDLQSS--------------LDN------QAA------------A------------- 7690_Tthe QQKSYIVK-TGS------------------------------------------------ 9133_Tthe ------------------------------------------------------------ 9821_Tthe NQASMFSNPRGGNRDRNVKDNTLSNQ---DSNTL------------G------------- MAK_Spur_MAK ---------------------N----GGGNGGGG------------N------------- MOK_Spur_MOK -----------------------------HH----------------------------- CC1G_11298_Ccin_MAK NV------------N--------------------------PHISGSVSPPPLHMLSLSP AqueK132_Aque_MAK --------------------------------GR------------N------------- AqueK133_Aque_MOK -----------------------------PS----------------------------- MAK_d_Smoe_MAK ---------------------------------R------------V------------- MAK_c_Smoe_MAK ---------------------------------R------------V------------- MAK_e_Smoe_MAK ---------------------L----SLSTASGG------------G------------- MAK_b_Smoe_MAK ------------------------------------------------------------ MAK_a_Smoe_MAK ---------------------L----SLSTASGG------------G------------- MOK_Smoe_MOK ------------------------------------------------------------ GK040_Glam_MOK -------THGGK-----------------GK----------------------------- GK041_Glam_MAK ------------------------------------------------------------ GK039_Glam_MAK ------------------------------------------------------------ MOK_Hsap_MOK -----------------------------------PQKDLKPAPQ--------------- MAK_Hsap_MAK -------------------------Y--------------IPSFL--------------- ICK_Hsap_MAK -------------------------Y--------------VPSFL--------------- CG4588_Dmel_MAK -------------------------Y--------------NSNLF--------------- MOK_Mmus_MOK -----------------------------------TQKDIKPHLK--------------- MAK_Mmus_MAK -------------------------Y--------------MPSFL--------------- ICK_Mmus_MAK -------------------------Y--------------IPSFL--------------- M04C9.5_Cele_MAK -------------------------K--------------TTTFS--------------- IME2_Scer_MAK -------------------------S---------------------------------- DDB0229430_Ddis_MAK QSQPPPQSQ----------------P--------------PPILT--------------- 13065_Tthe -----------------------------------PNNQYPPYKQ--------------- 15513_Tthe --------------------------SSATNSNNV--------AG--------------- 26702_Tthe -------------------------QVPNTQR-NI--------FN--------------- 27248_Tthe -----------------------------------SRNSHE------------------- 28968_Tthe -------------------------FFNQFNKVQVSNNNYQNYH---------------- 7690_Tthe ------------------------------------------------------------ 9133_Tthe ------------------------------------------------------------ 9821_Tthe -------------------------YVPSAIARNQ--------PS--------------- MAK_Spur_MAK -------------------------Y--------------MPSFS--------------- MOK_Spur_MOK -----------------------------------TTKTFQPAAS--------------- CC1G_11298_Ccin_MAK TLSPPLSPNPPWIQVQDIKENGLGGQSPPYI--TLQNRQFSPS----------------- AqueK132_Aque_MAK -------------------------L--------------LPYGQYGEGGRGRQWNGGGE AqueK133_Aque_MOK ----------------------------------AKSNTMFPTGR--------------- MAK_d_Smoe_MAK -------------------------Y--------------HPRF---------------- MAK_c_Smoe_MAK -------------------------Y--------------HPRF---------------- MAK_e_Smoe_MAK -------------------------R--------------NPML---------------- MAK_b_Smoe_MAK ------------------------------------------------------------ MAK_a_Smoe_MAK -------------------------R--------------NPML---------------- MOK_Smoe_MOK ------------------------------------------------------------ GK040_Glam_MOK -----------------------------------TSTSVSPGLE--------------- GK041_Glam_MAK ------------------------------------------------------------ GK039_Glam_MAK ------------------------------------------------------------ MOK_Hsap_MOK ----------Q------------------------------------------------- MAK_Hsap_MAK ----------KKEVQSAGQ-RIHLA--PLNATASEYTWNTK-------TGRGQFS----- ICK_Hsap_MAK ----------KKEIGSAMQ-RVHLA--PIPDPSPGYS-SLK-------AMRPH-P----- CG4588_Dmel_MAK ----------AMNVLAGII-ASHPD--ELIASPAQYEFHYSVHDSHSGDVKDQFEHRRGE MOK_Mmus_MOK ----------H------------------------------------------------- MAK_Mmus_MAK ----------KKEVGSAGQ-RIQLA--PLGASASDYTWSTK-------TGRGQFS----- ICK_Mmus_MAK ----------KKEIGSVMQ-RVQLA--PLAAPPPGYS-SLK-------AVRPH-P----- M04C9.5_Cele_MAK ----------AKKEGRTAV-QTRFE-----Y------------------A----Y----- IME2_Scer_MAK ------------------------------------------------------------ DDB0229430_Ddis_MAK ----------QQQQQQQQQ-QQQQQQLPSKTTI--Y------------HNTNH-L----- 13065_Tthe ----------K-----------------K------------------------------- 15513_Tthe ----------G------GYSL--------------------------------------- 26702_Tthe ----------N------GAAFLLNS--SY------------------------------- 27248_Tthe ----------------------------N------------------------------- 28968_Tthe ----------------------------N------------------------------- 7690_Tthe ----------------------------Q------------------------------- 9133_Tthe ------------------------------------------------------------ 9821_Tthe ----------N------LD-IYRFD--PK------------------------------- MAK_Spur_MAK ----------TKQDSSARI-GGYNE--PWKTTT-------K-------AG----V----- MOK_Spur_MOK ----------K-----------------N------------------------------- CC1G_11298_Ccin_MAK ------------PHSPL--------DI-----------------------HNYLQQ--PP AqueK132_Aque_MAK ARAGGGAFFGNRTRG--------VENV---------------------------T----- AqueK133_Aque_MOK ----------H-----------------H------------------------------- MAK_d_Smoe_MAK ------------------------------------------------------------ MAK_c_Smoe_MAK ------------------------------------------------------------ MAK_e_Smoe_MAK ------------------------------------------------------------ MAK_b_Smoe_MAK ------------------------------------------------------------ MAK_a_Smoe_MAK ------------------------------------------------------------ MOK_Smoe_MOK ------------------------------------------------------------ GK040_Glam_MOK ----------Q------------------------------------------------- GK041_Glam_MAK ------------------------------------------------------------ GK039_Glam_MAK ------------------------------------------------------------ MOK_Hsap_MOK --------CRLPTI---------------------------------------------- MAK_Hsap_MAK --GR----TYNPT-----------------AKNLNIVN-----RAQPIPSVH-------- ICK_Hsap_MAK --GR----PFFHT---------------QPRSTPGLIP-----RPPAAQPVH-------- CG4588_Dmel_MAK YVTGRYS-LVDPD-----------------GHR-RIVD-----Y--TADPLL-------- MOK_Mmus_MOK --------YHLPTI---------------------------------------------- MAK_Mmus_MAK --GR----TYNPT-----------------AKNLNIVN-----RTQPVPSVH-------- ICK_Mmus_MAK --GR----PFFHT---------------QPRSTPGLIP-----RPPAAQPVH-------- M04C9.5_Cele_MAK --GS----SFCS------------------SHK-SL----------FLFVFL-------- IME2_Scer_MAK ----------MPDFTPR---------------NFLIPT-----LKKSRE-KFE------- DDB0229430_Ddis_MAK --NA----PIPPN------------------HQR---------------GIS-------- 13065_Tthe --SKKFNEEYLVLG---------------------------------------------- 15513_Tthe ---------SNPVYGAKSNQTSSTTTNANALTNKNIYD-----FNHVRQP---------- 26702_Tthe ----KNQFKYSPQFNQS-------------SSNNQVSQ-----NQNAQNQ---------- 27248_Tthe ----IKNSQQSQSDCQS-------------D-D-S-NE-----------N---------- 28968_Tthe ----NKNSSLPPEYRNV---------------N-NEAE-----------S---------- 7690_Tthe ----MRNSKYKPG----------------------------------------------- 9133_Tthe ------------------------------------------------------------ 9821_Tthe ----PQANTYNPSFAAN---------------N-NMNN-----GSKINNDIYN------- MAK_Spur_MAK --TN----TFGA------------------ARNNGL----------RAQPVH-------- MOK_Spur_MOK ----VYGHFQLPSI---------------------------------------------- CC1G_11298_Ccin_MAK S---PF---NNPSAPAQP---PTTGQT--P--------RSANS---AINPIFKVVSLDPD AqueK132_Aque_MAK --TT----TAAAA-----------------AASNNHRGGGGGGSVLPNLGLL-------- AqueK133_Aque_MOK ----QIGPTHLPSL---------------------------------------------- MAK_d_Smoe_MAK ------------------------------------------------------------ MAK_c_Smoe_MAK ------------------------------------------------------------ MAK_e_Smoe_MAK --------------------------------------------------QF-------- MAK_b_Smoe_MAK ------------------------------------------------------------ MAK_a_Smoe_MAK --------------------------------------------------QF-------- MOK_Smoe_MOK ------------------------------------------------------------ GK040_Glam_MOK --------NNLPVLGAK---------------NYTVTT-----QRPYQN-KI-------- GK041_Glam_MAK ------------------------------------------------------------ GK039_Glam_MAK ------------------------------------------------------------ MOK_Hsap_MOK ---------------------------------VRKGGR MAK_Hsap_MAK ----------------------GRT-D---WVAKYGGHR ICK_Hsap_MAK ----------------------GRT-D---WASKYASRR CG4588_Dmel_MAK ----------------------GFNAQ---VRREPISRY MOK_Mmus_MOK --------------------------------NRKGGEY MAK_Mmus_MAK ----------------------GRT-D---WVAKYGGHR ICK_Mmus_MAK ----------------------GRI-D---WSSKYPSRR M04C9.5_Cele_MAK -----------------------LP-F---GACLSSQYS IME2_Scer_MAK ---------------------P-HL-S-NSNQHFGNVTF DDB0229430_Ddis_MAK ----------------------PQF-Y---NETTNNSKL 13065_Tthe -------------------------------KKPVFNKQ 15513_Tthe ---------------------VRNL-G-LPG-PKFDIKF 26702_Tthe ---------------------FNQS-N-SPSSKYFIKFH 27248_Tthe ---------------------NDKF-I-KD-FEDIKLAK 28968_Tthe ---------------------Q-QL-N-KMFEDKLNWAF 7690_Tthe ----------------------------TT-CTPYTAQN 9133_Tthe ------------------------------------NSI 9821_Tthe ---------------------FDNV-I-TN-NRKIQLPQ MAK_Spur_MAK ----------------------GRT-D---WASKYGGVR MOK_Spur_MOK -------------------------------SKSKEAQF CC1G_11298_Ccin_MAK VMLFYRCLTYSTALTSPSTTFIT--APCRP-TSEFYIPD AqueK132_Aque_MAK ----------------------ARV-D-----WSSRYKR AqueK133_Aque_MOK --------------------------G-KP-YYVQRTNQ MAK_d_Smoe_MAK ------------------------------RSRNFVKTK MAK_c_Smoe_MAK ------------------------------RSRNFVKTK MAK_e_Smoe_MAK ----------------------GEN-DYL-ALQVYQGYP MAK_b_Smoe_MAK ------------------------Q-Q-LTCKMATQCVI MAK_a_Smoe_MAK ----------------------GEN-DYL-ALQVYQGYP MOK_Smoe_MOK ------------------------------------RRY GK040_Glam_MOK -----------------------GV-S-SP-YRDHVKRK GK041_Glam_MAK --------------------------------------- GK039_Glam_MAK --------------------------------------I