CLUSTAL W (1.83) multiple sequence alignment RIOK3_Hsap_RIO3 MDLVG-VASPE--PGTAAAWGPSKCPWAIPQN-TISCSLADVMSEQLAK----------- RIOK2_Hsap_RIO2 MGK-------------------------------VNVAKLRYMSRDDFR----------- RIOK1_Hsap_RIO1 MDYRR-LLMSRVVPGQF-------------------------------D----------- CG11660_Dmel_RIO1 MNNDS-HKYSDAEEDEE--------------------DLRSSEWTNDFK----------- CG11859_Dmel_RIO2 MGK-------------------------------LNVTVLRYLTKEDFR----------- CG3008_Dmel_RIO3 MSSPW-VKTSE--PV-------------------QQVNLADIMSEQYAH----------- M01B12.5_Cele_RIO1 MEKVEHLNLNIQN----------------------------ILEDVD------------- aSWK440_Cele_RIO2 MGR-------------------------------MNVSMMRYLEGDHFR----------- RIO2_Scer_RIO2 MKL--------------------------------DTSHMRYLTTDDFR----------- RIO1_Scer_RIO1 MSLED-K----------------------------------------------------- RIOK1_Mmus_RIO1 MDCSL-DRMASVVPGQF-------------------------------D----------- RIOK2_Mmus_RIO2 MGK-------------------------------VNVAKLRYMSRDDFR----------- RIOK3_Mmus_RIO3 MDLVG-VSSPE--PGPAAAWGPSKCPWATPQN-TVSCSLTEVMSEELAK----------- ZK632.3_Cele_RIO3 MANCE-NNPWK--K---NAWGKNEE---T-AE-EPIVSFADVLSEEFIE----------- Rio1_Ddis_RIO1 MEDSF-KNLTIEN------------------------------K-EQQT----------- Rio2_Ddis_RIO2 MKL--------------------------------DPKALRYLSKDDFR----------- 11147_Tthe_RIO1 MSQKKETKQKK-I----------------------------VLVDDYFN----------- 27105_Tthe_RIO2 MRL--------------------------------DPSYLEYMTKDEFR----------- RIO1_Spur_RIO1 IYKTS-I-LTFKDRDKY-------------------------VT-GEFRFRHGYCKSNPR RIO2_Spur_RIO2 MAA-------------------------------E-----RKISRDRFN----------- RIO3_Spur_RIO3 MLEEG-KE---------------------------------------------------- CC1G_04984_Ccin_RIO1 MASHE-VE-----PGQF-------------------------------D----------- CC1G_13652_Ccin_RIO2 MKL--------------------------------DATDLRYVTSEEFR----------- AqueK049_Aque_RIO1 MRSRL-IF-----PGHP-------------------------------G----------- AqueK050_Aque_RIO2 MGR-------------------------------LDVSLLRYLTSQDFR----------- AqueK051_Aque_RIO3 MDSGL-NT-LS--PHKPT---PTKSPWGSPMPATPTCSLASVMDEELAR----------- RIO1-2_Smoe_RIO1 RPNANG--------------------------------------G--------------- RIO1-1_Smoe_RIO1 RPNANG--------------------------------------G--------------- RIO2-2_Smoe_RIO2 MKL--------------------------------DVNVLRYLSKDEFR----------- RIO2-1_Smoe_RIO2 MKL--------------------------------DVNVLRYLSKDEFR----------- GK011_Glam_RIO2 MSKFI-SLIAMPN---------------------LDVSYVDSLPPSYYR----------- GK010_Glam_RIO1 MNQLRT-V---------------------------------------------------- RIOK3_Hsap_RIO3 --ELQ--LE----EEAAV-F----------PE--V------------------------- RIOK2_Hsap_RIO2 --VLT--AV----EMGMK-N-HE-I-V-PGSL--IASIA--------------------- RIOK1_Hsap_RIO1 ----D--AD----SSDSE-N-RD-L-K-TV------------------------------ CG11660_Dmel_RIO1 --NLT--LK----HEIFK-D-IK-L-T-PKED--CDDLA--------------------- CG11859_Dmel_RIO2 --VLT--AI----EMGMK-N-HE-L-V-PGPL--AAAIA--------------------- CG3008_Dmel_RIO3 --KLH--DK----ELQRH-TE-K-LKR-PDEQ--IAPVWGSQASSPPAPNAQSIQSDAED M01B12.5_Cele_RIO1 --------I----DTASS-S-SD-D-E-PEQA--VV------------------------ aSWK440_Cele_RIO2 --VLI--AV----EMGMK-N-HE-V-V-PLAL--VSAIA--------------------- RIO2_Scer_RIO2 --VLQ--AV----EQGSR-S-HE-V-V-PTPL--IHQIS--------------------- RIO1_Scer_RIO1 ------------------------------------------------------------ RIOK1_Mmus_RIO1 ----D--AD----SSDSE-N-KE-L-Q-PI------------------------------ RIOK2_Mmus_RIO2 --VLT--AV----EMGMK-N-HE-I-V-PCSL--IASIA--------------------- RIOK3_Mmus_RIO3 --ELQ--LE----EEAAA-F----------PE--V------------------------- ZK632.3_Cele_RIO3 --DLS--VQEKLEEERYM-KQLD-QMF-GDTS--V------------------------- Rio1_Ddis_RIO1 --VTT--TT----TTTTTTT-KK-I-QTLEVP--LR------------------------ Rio2_Ddis_RIO2 --TLV--AV----EMGMK-N-HE-L-V-PVSL--ICTIA--------------------- 11147_Tthe_RIO1 --PTK--ED----EQG-N-N-QS-N-N-PENL--DE------------------------ 27105_Tthe_RIO2 --VLT--AI----EIGMR-N-HE-L-V-PMHL--IERIS--------------------- RIO1_Spur_RIO1 KMVRT--WA----EKEMR-N-LLRV-Q-PPRNPVSISTA--------------------- RIO2_Spur_RIO2 --AYCSDQL----EMGMK-N-HE-I-V-PSNL--VASIA--------------------- RIO3_Spur_RIO3 ------------------------------------------------------------ CC1G_04984_Ccin_RIO1 ----D--AP----EEING-R-GN-V-A-YI------------------------------ CC1G_13652_Ccin_RIO2 --VLT--AV----EMGSK-N-HE-I-V-PTHL--IVQIS--------------------- AqueK049_Aque_RIO1 ----N--LH----AIHSV------------------------------------------ AqueK050_Aque_RIO2 --VLT--GV----EMGMK-N-HE-I-V-PAEL--ISSIA--------------------- AqueK051_Aque_RIO3 --SFQ--AE----EEKLL-KK-E-MER-PVPS--VSPV---------------------- RIO1-2_Smoe_RIO1 --------V----ENALQ-K-NA-L-Q-PRNN--QN------------------------ RIO1-1_Smoe_RIO1 --------V----ENALQ-R-NA-L-Q-PRNN--QN------------------------ RIO2-2_Smoe_RIO2 --VLT--AV----EMGMK-N-HE-I-V-PAEL--IDRIA--------------------- RIO2-1_Smoe_RIO2 --VLT--AV----EMGMK-N-HE-I-V-PAEL--IDRIA--------------------- GK011_Glam_RIO2 --VLT--AV----EMGMK-N-HD-Y-V-PLNL--VISLS--------------------- GK010_Glam_RIO1 ------------------------------------------------------------ RIOK3_Hsap_RIO3 -------AVAEGPFIT-GENIDTSSDLML-AQMLQMEYDREYDA--QLRREEKKFNGDSK RIOK2_Hsap_RIO2 -------S-----LKH-GG----------------------------------------- RIOK1_Hsap_RIO1 -------K-----------EKD---D-IL-FEDLQDN----VNE--NGEGEI-------- CG11660_Dmel_RIO1 -------------------------------QVIATA----NEEDEPEDEEP-------- CG11859_Dmel_RIO2 -------N-----LKS-GG----------------------------------------- CG3008_Dmel_RIO3 WEDYSALLNDEGNVAE-DIQLPEDSDAVI-AQLLQSQFDHEYNE--ELRRIERQQNKQSK M01B12.5_Cele_RIO1 --------------------------------------------------------KQEK aSWK440_Cele_RIO2 -------G-----IHR-GG----------------------------------------- RIO2_Scer_RIO2 -------G-----MRSQSG----------------------------------------- RIO1_Scer_RIO1 ------------------------------------------------------------ RIOK1_Mmus_RIO1 -------H-----------AEDG--G-VL-LKSLQNA----AAE---VKGDA-------- RIOK2_Mmus_RIO2 -------S-----LKH-GG----------------------------------------- RIOK3_Mmus_RIO3 -------VVAEGPFIS-GENIDTSSDLML-AQMLQMEFDREYDA--QLRREEKKFNGDSK ZK632.3_Cele_RIO3 -------SDDQLPINT-----EGMTDEEV-ALALQRHFDREADV--A-----RAVGSSSS Rio1_Ddis_RIO1 -----------------------------------RN----GDLIEFSDSDE-------- Rio2_Ddis_RIO2 -------N-----LKY-GG----------------------------------------- 11147_Tthe_RIO1 -----------------------------------QE----YDQ--HSSSDEE---QYKK 27105_Tthe_RIO2 -------H-----LKR-VC----------------------------------------- RIO1_Spur_RIO1 -------Q-----------IEEG--N-LT-QKVLEAS-----L------EEA-------- RIO2_Spur_RIO2 -------N-----LRH-GG----------------------------------------- RIO3_Spur_RIO3 ----------------------TDSDLLL-AQMLQLQFNREYDA--ELSREEQKYNKDSK CC1G_04984_Ccin_RIO1 -------D-----------TVDP--S-TEPQLDLDDH----AWP--PSSDEE-------- CC1G_13652_Ccin_RIO2 -------G-----LRG-GG----------------------------------------- AqueK049_Aque_RIO1 -------------------MADT--K-VK-EKALEYD----AY----YSQ---------- AqueK050_Aque_RIO2 -------G-----IRS-SG----------------------------------------- AqueK051_Aque_RIO3 -------GNEELPING-GGAESTDSDFLL-AQMLQLEFDKEHDR--QLTAEEKHYNKQSR RIO1-2_Smoe_RIO1 ---------------------------------------------------QR---FLSH RIO1-1_Smoe_RIO1 ---------------------------------------------------QR---FLSH RIO2-2_Smoe_RIO2 -------G-----LKT-GG----------------------------------------- RIO2-1_Smoe_RIO2 -------G-----LKT-GG----------------------------------------- GK011_Glam_RIO2 -------G-----IRH-GS----------------------------------------- GK010_Glam_RIO1 ------------------------------------------------------------ RIOK3_Hsap_RIO3 VSISFENYRKVH-P--YED-----SD-SSE---DEV--D-WQD-T---RDDPYRPAKPV- RIOK2_Hsap_RIO2 ------------------------------------------------------------ RIOK1_Hsap_RIO1 --------------EDEE-----EEG-YDD---DDDDWD-WDE-G---VGKLAKGYVWN- CG11660_Dmel_RIO1 --------------EEYD-----EDD-YDD---IGDDYDTYEE-A---YTGFNKLHVQP- CG11859_Dmel_RIO2 ------------------------------------------------------------ CG3008_Dmel_RIO3 VTVTLNKFLRDGDAEFLHD--TAEDD-YEE---DEL--E-QQKHDWDRFEDNERQLDSI- M01B12.5_Cele_RIO1 LEAG----------EQIEEQYDTDSDY------DDDIVE-FAE-A---T----------- aSWK440_Cele_RIO2 ------------------------------------------------------------ RIO2_Scer_RIO2 ------------------------------------------------------------ RIO1_Scer_RIO1 --------------------------F--------------------------------- RIOK1_Mmus_RIO1 --------------ETDE-----EDD-YDD---D-DDWY-LDD-A---TGKLTKGCTWN- RIOK2_Mmus_RIO2 ------------------------------------------------------------ RIOK3_Mmus_RIO3 VSISFENYRKVH-P--FED-----SD-SSE---DEV--D-WQD-T---RDDPYRPAKPI- ZK632.3_Cele_RIO3 VHFTPDRYHPKT-M--Q-E--TD-SE-NED---DDA--L-RQA-A---TDMLYAKLDEE- Rio1_Ddis_RIO1 -------------------EYYYDDDY--------EEIE-YDS-D---L---SDEENED- Rio2_Ddis_RIO2 ------------------------------------------------------------ 11147_Tthe_RIO1 VSKK----------KKNRK-VSSDDDL--------DELD-YLE-V---A---------VH 27105_Tthe_RIO2 ------------------------------------------------------------ RIO1_Spur_RIO1 --------------EWDE-----DDD-GEE---DDDYYD-WEE-E---STDFTKKFNTV- RIO2_Spur_RIO2 ------------------------------------------------------------ RIO3_Spur_RIO3 VGISFSNYRSVH-P--AYD--DN-ED-DDD---DDD--D-YQE-EWI-LGDEGREAELL- CC1G_04984_Ccin_RIO1 --------------DEDHDSLLDEDDYYDNTRVEDEDW---DI-A---ERDFTKQYNRL- CC1G_13652_Ccin_RIO2 ------------------------------------------------------------ AqueK049_Aque_RIO1 --------------SSEG-----EEE-EEE---DDIGWH-FEE-E---TADFTKKYNAM- AqueK050_Aque_RIO2 ------------------------------------------------------------ AqueK051_Aque_RIO3 VKISFDNYRSLH-P--AYL--NH-QE-EEE---EE---------V---VDDEYEMTVRI- RIO1-2_Smoe_RIO1 IRAG----------PL-HE----------------------------------------- RIO1-1_Smoe_RIO1 IRAG----------PL-HE----------------------------------------- RIO2-2_Smoe_RIO2 ------------------------------------------------------------ RIO2-1_Smoe_RIO2 ------------------------------------------------------------ GK011_Glam_RIO2 ------------------------------------------------------------ GK010_Glam_RIO1 ------------------------------------------------------------ RIOK3_Hsap_RIO3 -PT---PKKGFIGKGK-DITTKHDEVVC-GRKN----TAR-------------------- RIOK2_Hsap_RIO2 ------------------------------------------------------------ RIOK1_Hsap_RIO1 -GGSN-P-----QANR-Q--TSDSSSAK-MSTP----ADK-------------------- CG11660_Dmel_RIO1 -QLTN-ASGGGSGGGA-GGASGGSQRVS-SYQP----NEK-------------------- CG11859_Dmel_RIO2 ------------------------------------------------------------ CG3008_Dmel_RIO3 -PR---CG-FKVNKEG-EMITKHDPQLC-AVRN----AQR-------------------- M01B12.5_Cele_RIO1 -G-----D---------------------------------------------------- aSWK440_Cele_RIO2 ------------------------------------------------------------ RIO2_Scer_RIO2 ------------------------------------------------------------ RIO1_Scer_RIO1 -DSL-SVSQGAS---D-HI------------------NNQ-------------------- RIOK1_Mmus_RIO1 -GGSN-Y-----QANR-Q--TSNYNSAK-MSTP----IDK-------------------- RIOK2_Mmus_RIO2 ------------------------------------------------------------ RIOK3_Mmus_RIO3 -PT---PKKGFIGKGK-DITTKHDEVVC-GRKN----TAR-------------------- ZK632.3_Cele_RIO3 -NA---TNSRLRPEGPSTSRTKHDTGVS-GRRN----ADK-------------------- Rio1_Ddis_RIO1 -R-----ILGIR-SSI-PL--N-----KTLQPK----AQA-------------------- Rio2_Ddis_RIO2 ------------------------------------------------------------ 11147_Tthe_RIO1 KG-----NIGLE-DGQ-GLAVS-----ETNDAK----QGR-------------------- 27105_Tthe_RIO2 ------------------------------------------------------------ RIO1_Spur_RIO1 -RACN-P-----QPKR-GMNPANPKEVS-SFQP----HEK-------------------- RIO2_Spur_RIO2 ------------------------------------------------------------ RIO3_Spur_RIO3 -AP---P-SPSPGQKK-SIVTKHDAQVC-GRKN----ASR-------------------- CC1G_04984_Ccin_RIO1 -RQHVAVKTGNA---Q-GSASATNQSASVAALPAVNIPKAVKAAKPTAAIPAGVAAKDRT CC1G_13652_Ccin_RIO2 ------------------------------------------------------------ AqueK049_Aque_RIO1 -KKG--------------ETQSNPNAARGTSHC----SNN-------------------- AqueK050_Aque_RIO2 ------------------------------------------------------------ AqueK051_Aque_RIO3 -PR---SSGRKKGVSP-GQPTKHDSKIC-GQKN----VRN-------------------- RIO1-2_Smoe_RIO1 ------------------------------------------------------------ RIO1-1_Smoe_RIO1 ------------------------------------------------------------ RIO2-2_Smoe_RIO2 ------------------------------------------------------------ RIO2-1_Smoe_RIO2 ------------------------------------------------------------ GK011_Glam_RIO2 ------------------------------------------------------------ GK010_Glam_RIO1 ------------------------------------------------------------ RIOK3_Hsap_RIO3 ---MENF----APEFQVG--D---------GIGMDLKLSNHVFNALKQ-HAYSEERRSAR RIOK2_Hsap_RIO2 ---------------------------------CNKVLRELVKHKLIA-WERTKTVQGYR RIOK1_Hsap_RIO1 --VLRKF----ENKINLD------------K----LNVTDSVINKVTE-KSRQKEADMYR CG11660_Dmel_RIO1 --LLRRY----SARINVE------------KYDPTTNMSAQAANRLVN-FD---RRDRTQ CG11859_Dmel_RIO2 ---------------------------------VHKLLKELCKHKLLA-YERGKKYDGYR CG3008_Dmel_RIO3 ---VMSF----PPEFPTG--D---------AAGFDMKLSNKVFNQLRA-HSRR-----GR M01B12.5_Cele_RIO1 ------F----TKKLNAARLN---------TIGPNA-ARNRLTVDVERHADTSEDRKRKR aSWK440_Cele_RIO2 ---------------------------------VARTLNDLCKHSLVA-FERSKKFDGYR RIO2_Scer_RIO2 ---------------------------------TNRAISDLAKLSLIS-KMRNVKYDGYR RIO1_Scer_RIO1 --LLEKY----SHKIK---------------------------------TDELSFSRAKT RIOK1_Mmus_RIO1 --SLRKF----ENKINLN------------K----LNVTDSVTNKVTV-KLRQKEAESYR RIOK2_Mmus_RIO2 ---------------------------------CNKILRELVKHKLIA-WERTKTVQGYR RIOK3_Mmus_RIO3 ---MENF----APGFQVG--D---------GIGMDLKLSNHVFNALKQ-HAYSEERRSAR ZK632.3_Cele_RIO3 --T-FND----RNTLPTG--D---------MVG--DKLNNKVFNKLMA-FGKSESKRQMR Rio1_Ddis_RIO1 --LEQKY----QNKINVNSIANSISSKRVIDDDSHRALPNSVQNSIKE-IKKKDDKQGVR Rio2_Ddis_RIO2 ---------------------------------TKKSIQTLHKFKLLF-HDGR-NYDGYK 11147_Tthe_RIO1 --LVAKL----SSKISV---E---------KMGSRTTASHGAMQSIKE-SINKSQKGSNR 27105_Tthe_RIO2 ---------------------------------ASKVVKLLLKNKFIA-HEN-KKFDGYK RIO1_Spur_RIO1 --SMHRY----ASKITVD------------KYSGPRSLSNSATNSLMK-TKRKVESDRVR RIO2_Spur_RIO2 ---------------------------------CHKVLKELVRNKLIA-WEHG-KVSGYR RIO3_Spur_RIO3 --VMNQF----PPAFPTG--N---------SFGMDMKLSNSVYNVLKI-HSQKEESKAQR CC1G_04984_Ccin_RIO1 TSQLEEYTKKYSSRLA--------------KI-------DTPFTMGVG-VNRKGPSAHAN CC1G_13652_Ccin_RIO2 ---------------------------------VNKLIGSLAKRNLIS-KVQNAKYEGYR AqueK049_Aque_RIO1 --PLRKY----ENLINLG------------SYA--PALSSSSLNALEG-LCRKTESLRVR AqueK050_Aque_RIO2 ---------------------------------CYKILRELAKHRLVT-YEHQ-KVCGYR AqueK051_Aque_RIO3 ---MEKF----PPDFPMG--D----------VQPGLCLDNSVFNVLKE-HSMREEKQSQR RIO1-2_Smoe_RIO1 ------W----E-------------------GQTNTVMSNSVTTMVRD-NVRKQAEGRVR RIO1-1_Smoe_RIO1 ------W----E-------------------GQTNAVMSNSVTTMVRD-NVRKQAEGRVR RIO2-2_Smoe_RIO2 ---------------------------------AYKNIRTLLRHKLVH-HDST-KYDGYR RIO2-1_Smoe_RIO2 ---------------------------------AYKNIRTLLRHKLVH-HDST-KYDGYR GK011_Glam_RIO2 ---------------------------------IPHIVQELLKIKLIS-HIG-APIDGYA GK010_Glam_RIO1 ------------------------------------------TN---------RVKHARK RIOK3_Hsap_RIO3 LHEKKEHSTAEKAVDPKTRLLMYKMVNSGMLETITGCISTGKES---------------- RIOK2_Hsap_RIO2 L-----------TNAGYDYLALKTLSSRQVVESVGNQMGVGKES---------------- RIOK1_Hsap_RIO1 IKDKADRATVEQVLDPRTRMILFKMLTRGIITEINGCISTGKEA---------------- CG11660_Dmel_RIO1 VRDKHDRATAEQVMDPRTRMILFKLLNRGMIQEINGCISTGKEA---------------- CG11859_Dmel_RIO2 L-----------TNTGYDYLALKSLTLRGSVSSFGNQIGIGKES---------------- CG3008_Dmel_RIO3 SDKHEKVATAEMGLDAGTRLLLYKLINNQILEQINGIISTGKEA---------------- M01B12.5_Cele_RIO1 VKDRADRATVEQVLDPRTRLVLFRLLQRGTLLNIDGCISTGKEA---------------- aSWK440_Cele_RIO2 L-----------TIRGYDYLALRALCSREVVGSVGNQIGIGKES---------------- RIO2_Scer_RIO2 L-----------TYNGIDYLALKTMLNRDTVYSVGNTIGVGKES---------------- RIO1_Scer_RIO1 SKDKANRATVENVLDPRTMRFLKSMVTRGVIADLNGCLSTGKEA---------------- RIOK1_Mmus_RIO1 IKDKADRATVEQVLDPRTRMILFKLLHKDHISEIHGCISTGKEA---------------- RIOK2_Mmus_RIO2 L-----------TNAGYDYLALKTLSSRQVVESVGNQMGVGKES---------------- RIOK3_Mmus_RIO3 LHEKKEHSTAEKAVDPKTRLLMYKMVNSGMLETITGCISTGKES---------------- ZK632.3_Cele_RIO3 NKDKEEKATMDTSVDSDTRLLLLKWINQGVFDSVDGIIATGKES---------------- Rio1_Ddis_RIO1 IVDKEDRATTEQVLDPRTRLMLFKMINKGAFSEINGCISTGKEA---------------- Rio2_Ddis_RIO2 L-----------TYLGYDFLALKTLVSRGVCSYVGNQIGVGKES---------------- 11147_Tthe_RIO1 VKDKSDRATVEQVLDPRTRVILVKLLNKKIINEINGCLSTGKEA---------------- 27105_Tthe_RIO2 L-----------TYLGYDYLALQVFIRRGAIKEVLGKVGCGKES---------------- RIO1_Spur_RIO1 VKDKADRATMEQVMDPRTRMILFKMLSRNVIYEINGCISTGKEA---------------- RIO2_Spur_RIO2 L-----------TYPGYDYLALKALVARDAVASVGNQIGVGKES---------------- RIO3_Spur_RIO3 LHEKKEHSTAEMAVDSRTRIMLYKLVNNGMLDSITGTISTGKEA---------------- CC1G_04984_Ccin_RIO1 MKDKSDRATNEQVLDPRTRLILFKMIGRGLIHEVNGCVSTGKEA---------------- CC1G_13652_Ccin_RIO2 L-----------TYGGYDYLAMRALSKRDSMTSVGNQIGVGKES---------------- AqueK049_Aque_RIO1 SKDKSDRATTEQVLDPRTRMILFKLLSRGLLSNISGCVSTGKEA---------------- AqueK050_Aque_RIO2 L-----------TNAGYDYLALRALVSKDVIYSVGNQIGVGKES---------------- AqueK051_Aque_RIO3 HHEKKEHSTQEHVLDPKTRLMLFKMVDSGKLGEVNGCLSTGKEA---------------- RIO1-2_Smoe_RIO1 VHEKSDRATVEQVKKKII----------------FNLLLFHLQA---------------- RIO1-1_Smoe_RIO1 VHEKSDRATVEQVLDPRTRMVLFKMLNRGVFHDINGCISTGKEASFCNCVFLSFNLLLFH RIO2-2_Smoe_RIO2 L-----------TNLGYDFLAIKTMVNRGLIVGVGRQIGVGKES---------------- RIO2-1_Smoe_RIO2 L-----------TNLGYDFLAIKTMVNRGLIVGVGRQIGVGKES---------------- GK011_Glam_RIO2 L-----------TYMGYDYLSLNVMKRRGVISAIGSRIGVGKEA---------------- GK010_Glam_RIO1 YDDKSDRATTNLVLDDRVRKLIFRLIEKGALLSVDSVINTGKEA---------------- : :: RIOK3_Hsap_RIO3 ---VVFHAYGGSMED-E----KEDS---------KVIPTECAIKVFKTTLNEF---KNRD RIOK2_Hsap_RIO2 ---DIYIVANEEGQ-------------------------QFALKLHRLGRTSFRNLKNKR RIOK1_Hsap_RIO1 ---NVYHASTANGE-------------------------SRAIKIYKTSILVF---KDRD CG11660_Dmel_RIO1 ---NVYHAVSKNGE------------------------EEFAIKIYKTSILVF---KDRD CG11859_Dmel_RIO2 ---NIYVVADEEGT-------------------------PICLKLHRLGRTCFRNVKAKR CG3008_Dmel_RIO3 ---VILHANSDANYTGS----NEHGHQSGVLVPPQLLPRECAIKIFKTTLNEF---KQRD M01B12.5_Cele_RIO1 ---NVYHATGTD-N-------------------------DLAIKIYKTSILTF---KDRE aSWK440_Cele_RIO2 ---DVYVGGDPELN-------------------------DLCLKFHRLGRTSFRKIKEKR RIO2_Scer_RIO2 ---DIYKVSDKNGN-------------------------PRVMKIHRLGRTSFHSVRNNR RIO1_Scer_RIO1 ---NVYHAFAGTGK--APVIDEETGQYE--VLETDGSRAEYAIKIYKTSILVF---KDRE RIOK1_Mmus_RIO1 ---NVYYASTPSGE-------------------------SRAIKIYKTSILMF---KDRD RIOK2_Mmus_RIO2 ---DIYIVANEAGQ-------------------------QLALKLHRLGRTSFRNLKNKR RIOK3_Mmus_RIO3 ---VVFHAYGGSLED-E----KEDG---------KAIPTECAIKVFKTTLNEF---KNRD ZK632.3_Cele_RIO3 ---AVLHAAQDSA-------------------------TSYAIKVYKTTLSEF---KNRS Rio1_Ddis_RIO1 ---NVYHAFTPNEE-------------------------ERAVKVYKTSILVF---KDRD Rio2_Ddis_RIO2 ---DIYIVANDDNQ-------------------------EMVLKLHRLGRVSFKTIKNNR 11147_Tthe_RIO1 ---NVYHASSSNGK-------------------------EYAIKIYKTSILVF---KDRE 27105_Tthe_RIO2 ---DIYKCVNENGD-------------------------FVILKFTRLGRTSFRTIKKNR RIO1_Spur_RIO1 ---NVYYATTKLGD-------------------------HRAIKIYKTSILTF---KDRD RIO2_Spur_RIO2 ---DIYIVANDNDE-------------------------QLALKLHRLGRTSFRKLKEKR RIO3_Spur_RIO3 ---VVIHAYGGQIDD-------------------HIIPPECALKVFKTTLNEF---KKRD CC1G_04984_Ccin_RIO1 ---NVYHATTPTK-------------------------DHLALKIYKTSILVF---KDRS CC1G_13652_Ccin_RIO2 ---DIYVVANAEGD-------------------------EMVLKLHRLGRISFRSIKTKR AqueK049_Aque_RIO1 ---NVYYADSATG--------------------------PCAVKVYKTSILIF---KDRD AqueK050_Aque_RIO2 ---G---------------------------------------------RTSFRKVKEKR AqueK051_Aque_RIO3 ---AVYHAEGGG-E-------LEDG---------TAVPDECAIKIFKTTLNEF---FRRD RIO1-2_Smoe_RIO1 ---NVYHATTESGE-------------------------ELAVKVYKTSILVF---KDRD RIO1-1_Smoe_RIO1 LQANVYHATTESGE-------------------------ELAVKVYKTSILVF---KDRD RIO2-2_Smoe_RIO2 ---DIFEVVAEDGQ-------------------------TLALKLHRLGRTSFRAVKSKR RIO2-1_Smoe_RIO2 ---DIFEVVAEDGQ-------------------------TLALKLHRLGRTSFRAVKSKR GK011_Glam_RIO2 ---DVYMAMRPNGQ-------------------------YVVLKLHKLGRTSFKTAKTKR GK010_Glam_RIO1 ---NVFLCNSEAG--------------------------NVALKIYSTSILSF---RNRI * . RIOK3_Hsap_RIO3 KYIKDDFRFKD--RFSKLNPRKIIRMWAEKEMHNL----------------------ARM RIOK2_Hsap_RIO2 DYHKH---------RHNVSWLYLSRLSAMKEFAYM----------------------KAL RIOK1_Hsap_RIO1 KYVSGEFRFRH--GYCKGNPRKMVKTWAEKEMRNL----------------------IRL CG11660_Dmel_RIO1 KYVSGEFRFRH--GYCKHNPRKMVRTWAEKEMRNY----------------------LRM CG11859_Dmel_RIO2 DYHGR---------RHKASWLYLSRISATREFAYM----------------------SAL CG3008_Dmel_RIO3 RYIKDDYRFKD--RFSKQNHRVIINMWAEKEMHNL----------------------MRM M01B12.5_Cele_RIO1 RYVTGEFRYRH--GYCKSNPRKMVAVWAEKEMRNL----------------------ARM aSWK440_Cele_RIO2 DYHKK---------RKSASWLYLSRLAAAKEFAFL----------------------KAL RIO2_Scer_RIO2 DYLKK--------SNQGANWMHLSRLAANKEYQFM----------------------SML RIO1_Scer_RIO1 RYVDGEFRFRN--SRSQHNPRKMIKIWAEKEFRNL----------------------KRI RIOK1_Mmus_RIO1 KYVTGEFRFRR--GYCKGNPRKMVRTWAEKEMRNL----------------------CRL RIOK2_Mmus_RIO2 DYHKH---------RHNVSWLYLSRLSAMKEFAYM----------------------KAL RIOK3_Mmus_RIO3 KYIKDDFRFKD--RFSKLNPRKIIRMWAEKEMHNL----------------------TRM ZK632.3_Cele_RIO3 EYVKDDFRFK--------NPRGVLKIWAEREFMNL----------------------SRM Rio1_Ddis_RIO1 RYVTGEFRFRR--GYSKHNPRKMVKVWAEKEFRNL----------------------TRL Rio2_Ddis_RIO2 DYLKH---------RKSASWLYLSRLAALKEFAYM----------------------KAL 11147_Tthe_RIO1 KYVAGEFRFRK--GHCKSNPRKMIKLWAEKEIRNL----------------------KRI 27105_Tthe_RIO2 DYIQH---------RTSYSWLYLSRLSAIKEYTFM----------------------DLL RIO1_Spur_RIO1 KYVTGEFRFRH--GYCKSNPRKMVRTWAEKEMRNL----------------------LRL RIO2_Spur_RIO2 DYLGK---------RKSASWLYLSRLAAMKEFAFM----------------------KAL RIO3_Spur_RIO3 QYIRNDYRFRA--RFKKQNPRKFIQMWAEKEMHNL----------------------NRM CC1G_04984_Ccin_RIO1 KYVTGEYRFRR--GYS-RNPRKMVRLWAEKEMRNL----------------------RRL CC1G_13652_Ccin_RIO2 DYMGK---------RKSASWMYLSRLSAQKEYAFM----------------------KVL AqueK049_Aque_RIO1 RYVNGEYRFRH--GYSRHNPRKMVRLWAEKEMRNL----------------------SRL AqueK050_Aque_RIO2 DYHRH---------RQTTSWLYLSRLAAQKEYTFMKCTCLMKNTFTVSISALFILSFQVL AqueK051_Aque_RIO3 KYIKEDYRFKN--RFGKQNPRKIVRLWAEKEMHNL----------------------KRL RIO1-2_Smoe_RIO1 KYVQGDFRFRH--GYSKHNPRKMVKTWAEKEMRNL----------------------LRL RIO1-1_Smoe_RIO1 KYVQGDFRFRH--GYSKHNPRKMVKTWAEKEMRNL----------------------LRL RIO2-2_Smoe_RIO2 DYLKH---------RSSFNWLYLSRLAALKEFAFM----------------------KAL RIO2-1_Smoe_RIO2 DYLKH---------RSSFNWLYLSRLAALKEFAFM----------------------KAL GK011_Glam_RIO2 DYMGP---------RKSASWMYLSRLAAVREFGFM----------------------VAL GK010_Glam_RIO1 EYVEGEHRFETVTRSQKSNSRRMVKLWAEKEFRNL----------------------IRT * . . * :* RIOK3_Hsap_RIO3 QRAG-IPCPTVVLLKKHILVMSFIGH-DQVPAPKLKEVK---LNS-EE------------ RIOK2_Hsap_RIO2 YERK-FPVPKPIDYNRHAVVMELIN---GYPLCQIHHV--E------D------------ RIOK1_Hsap_RIO1 NTAE-IPCPEPIMLRSHVLVMSFIGK-DDMPAPLLKNVQL---SE-SK------------ CG11660_Dmel_RIO1 RNAG-VPVPEPILLRSHVLVMRFCGR-DGWPAPKLKDVEL---ST-SK------------ CG11859_Dmel_RIO2 YDRG-FPVPKPIDFNRHCVLMDLVK---GWPMTQVHEL--L------D------------ CG3008_Dmel_RIO3 QAIG-LNVPDVVVLKKHVLVMRFIGD-NHNAAPKLKDAR---LSD-AE------------ M01B12.5_Cele_RIO1 HEVG-LPVPKPHLLKGHVLVMDFLGK-DGWPAPLLKNANL---SQ-EVAISKFYQFFVFF aSWK440_Cele_RIO2 QERG-FPVPKAVDVCRHLVVMQLVV---GQTLCNVTHV--E------D------------ RIO2_Scer_RIO2 YSKG-FKVPEPFDNSRHIVVMELIE---GYPMRRLRKH--K------N------------ RIO1_Scer_RIO1 YQSGVIPAPKPIEVKNNVLVMEFLSRGNGFASPKLKDYPY---KNRDE------------ RIOK1_Mmus_RIO1 KTAN-IPCPEPIRLRSHVLLMGFIGK-DDMPAPLLKNVQL---SE-SK------------ RIOK2_Mmus_RIO2 YERK-FPVPKPIDYNRHAVIMELIN---GYPLCQIHHV--E------D------------ RIOK3_Mmus_RIO3 QKAG-IPCPTVVLLKKHILVMSFIGH-DQVPAPKLKEVK---LSN-EE------------ ZK632.3_Cele_RIO3 AKHG-LPCPQPVKVRRNVLVMSFLGD-QGLAAPRLKNVEWEFFTD-DE------------ Rio1_Ddis_RIO1 KNAG-IPCPTPLILRNHILVMTFIGK-DGYAAPRLKDATV---SQ-EK------------ Rio2_Ddis_RIO2 YENG-FPVPTPIDYNRHCIVMSRAR---GYPLTQIVQL--R------H------------ 11147_Tthe_RIO1 YQSS-IPCPEPLIVKSNVLMMEFIGK-DGKAAPRLKDAEN--IEL-EQ------------ 27105_Tthe_RIO2 HKNN-FPTPIPIEQNRHGIVMSLIN---GVPMQNISEI--D------N------------ RIO1_Spur_RIO1 HNAG-VRCPEPHVLRSHVLVMDFIGI-DGWPAPLLKDVNL---SE-SK------------ RIO2_Spur_RIO2 YDHG-FPVPTPIDFSRHCVVMELMN---AYPLNQVHTL--D------D------------ RIO3_Spur_RIO3 REAG-IRCPEVVLLRKHILVMSYIGK-DQKAALKLKHVK---FSV-SE------------ CC1G_04984_Ccin_RIO1 RAAG-IESPEPVEVRENVLVMTFVGDRDGWASPRLKDAEL---TT-DQ------------ CC1G_13652_Ccin_RIO2 YEHG-FPIPKPIDQARHCVLMEFIN---AYPLRQISEV--P------S------------ AqueK049_Aque_RIO1 HQNG-IACPRPIILRGHVLVMSFLGS-GGWPHPKLKDANI---TD-KE------------ AqueK050_Aque_RIO2 HERG-FPVPQPMDVNRHCVVMELIN---GYPLCQVRSL--S------K------------ AqueK051_Aque_RIO3 HSHG-IHCPKVVLLKKHVLVMSFIGK-DQIPAPKLKDSQ---LTQ-DQ------------ RIO1-2_Smoe_RIO1 KASG-IRAPSPLVLRLHVLVMDFIGKSDGWAAPRLKDAAL---SD-TK------------ RIO1-1_Smoe_RIO1 KASG-IRAPSPLVLRLHVLVMDFIGKSDGWAAPRLKDAAL---SD-TK------------ RIO2-2_Smoe_RIO2 HEHG-FPTPKAVDWNRHCVLMTLVP---GYPLVQVKEL--K------N------------ RIO2-1_Smoe_RIO2 HEHG-FPTPKAVDWNRHCVLMTLVP---GYPLVQVKEL--K------N------------ GK011_Glam_RIO2 KERS-FPVPDPISINRHCVCMSYVE---GIPMHAIKDIDIE------A------------ GK010_Glam_RIO1 QQLGSICIPKPLFITTTMIGLEFIGY-DRAPAPRLKDVISD-LSQ-AR------------ . * : : . : RIOK3_Hsap_RIO3 ------------------------------MKEAYYQTLHLMRQLYHECTLVHADLSEYN RIOK2_Hsap_RIO2 ------------------------------PASVYDEAMELIVKLA-NHGLIHGDFNEFN RIOK1_Hsap_RIO1 ------------------------------ARELYLQVIQYMRRMYQDARLVHADLSEFN CG11660_Dmel_RIO1 ------------------------------ARELYRDCVVIMWRIYNQCRLVHADLSEFN CG11859_Dmel_RIO2 ------------------------------APQVYDDLMNLIVRLG-NSGVIHGDFNEFN CG3008_Dmel_RIO3 ------------------------------LSCAYEEIVAAMHKLYNEAKLVHADMSEYN M01B12.5_Cele_RIO1 FDEKNKNLQNFYLKKKNVILSKTSKKPKKDAEPMYVGLVRDMRRLYRECKLVHADLSEFN aSWK440_Cele_RIO2 ------------------------------AGALYDRLMALIVKMA-RHGVIHGDFNEFN RIO2_Scer_RIO2 ------------------------------IPKLYSDLMCFIVDLA-NSGLIHCDFNEFN RIO1_Scer_RIO1 ------------------------------IFHYYHTMVAYMRLLYQVCRLVHADLSEYN RIOK1_Mmus_RIO1 ------------------------------ARELYLQVIQYMRKMYQDARLVHADLSEFN RIOK2_Mmus_RIO2 ------------------------------PASVYDEAMELIVKLG-NHGLIHGDFNEFN RIOK3_Mmus_RIO3 ------------------------------MKDAYYQTLHLMQQLYNECTLVHADLSEYN ZK632.3_Cele_RIO3 ------------------------------RRNVYDQVQSIMCRMYKECLLVHADLSEFN Rio1_Ddis_RIO1 ------------------------------FGVIYLDCIKMMRTLFHKCRLVHADLSEYN Rio2_Ddis_RIO2 ------------------------------PSKVYSDLMNLIVKLA-SYGLIHGDFNEFN 11147_Tthe_RIO1 ------------------------------YSKIYLQLLRDMRTLYQDCRLVHGDLSEYN 27105_Tthe_RIO2 ------------------------------PKYVFDQCFYLIKRLA-ENGLIHSDFNEFN RIO1_Spur_RIO1 ------------------------------ARELYLECIQQVRRIYQKAKLVHADLSEFN RIO2_Spur_RIO2 ------------------------------PASVYDDLMNLIVRLA-NHGLIHGDFNEFN RIO3_Spur_RIO3 ------------------------------AQCVYEEC---------------------- CC1G_04984_Ccin_RIO1 ------------------------------MIPLYSNLLCLIRTMYHDCKLVHADLSEYN CC1G_13652_Ccin_RIO2 ------------------------------PGKLYSTLMDLIVRFA-QAGLIHGDFNEFN AqueK049_Aque_RIO1 ------------------------------ARELYLECVLIIRKLFWSCKLVHADLSEYN AqueK050_Aque_RIO2 ------------------------------PEVLFNTLMALLVRLA-SHGLLHCDFNEFN AqueK051_Aque_RIO3 ------------------------------LKSAYHQCVQTMEKMYNDCHLVHADLNEFN RIO1-2_Smoe_RIO1 ------------------------------YRESYLEIVQIMRTMYQRCRLVHGDLSEYN RIO1-1_Smoe_RIO1 ------------------------------YRESYLEIVQIMRTMYQRCRLVHGDLSEYN RIO2-2_Smoe_RIO2 ------------------------------PALVFDTVISLIVRLA-EHGLIHCDFNEFN RIO2-1_Smoe_RIO2 ------------------------------PALVFDTVISLIVRLA-EHGLIHCDFNEFN GK011_Glam_RIO2 ------------------------------ANLLAKDIHTQMVRML-RYGIVHGDCNEFN GK010_Glam_RIO1 ------------------------------IIKLYWSIMRVLRTLYIGAGLVHGDLSEYN RIOK3_Hsap_RIO3 MLWH----------AGKVWLIDVSQSVEPTHPHGL----EFLFRDCRNVSQFFQKGGVKE RIOK2_Hsap_RIO2 LILDES---------DHITMIDFPQMVSTSHPNAE----WYFDRDVKCIKDFFMKRFSYE RIOK1_Hsap_RIO1 MLYHG----------GGVYIIDVSQSVEHDHPHAL----EFLRKDCANVNDFFMRHSVAV CG11660_Dmel_RIO1 ILLQD----------GQLVIIDVSQSVEHDHPHSF----DFLRKDCTNISEFFRKRAVAT CG11859_Dmel_RIO2 LMVTDA---------GKPILIDFPQMMSTSHENAE----FFFERDVNCVREMFRRKFGYE CG3008_Dmel_RIO3 ILWF----------EGKCWFIDVAQSVEPKHPSAL----EFLMRDCGNIVNFFERRGLPN M01B12.5_Cele_RIO1 MLVHD----------GKLWIIDVSQSVEQDHPHAL----EFLRMDCNNVNKFFRELGVPV aSWK440_Cele_RIO2 LIMLED---------ERIVMIDFPQMVSIDHPNAE----YYFDRDVTCVRTFFKRKFDYE RIO2_Scer_RIO2 IMIKDKLED---ENDCGFVVIDFPQCISIQHQDAD----YYFQRDVDCIRRFFKKKLKYE RIO1_Scer_RIO1 TIVHD----------DKLYMIDVSQSVEPEHPMSL----DFLRMDIKNVNLYFEKMGISI RIOK1_Mmus_RIO1 MLYHG----------GDVYIIDVSQSVEHDHPHAL----EFLRKDCTNVNDFFSKHAVAV RIOK2_Mmus_RIO2 LMLDKD---------DHITMIDFPQMVSTSHPNAE----WYFDRDVKCIREFFMKRFSYE RIOK3_Mmus_RIO3 MLWH----------AGKVWLIDVSQSVEPTHPHGL----EFLFRDCRNVSQFFQKGGVTE ZK632.3_Cele_RIO3 LLLTP---------DNKVHVIDVSQAMDLSHPRSL----QFLTRDIQNIITFFTRIGTPN Rio1_Ddis_RIO1 MLYYK----------NQLYIIDVSQSVEHDHPHSL----DFLRMDCSNVTDFFRKKEVNT Rio2_Ddis_RIO2 ILINDE---------EEITLIDFPQMVSTSHLNAE----MYFDRDVTCIRVFFEKRFNFI 11147_Tthe_RIO1 LLYYN----------EKLYMIDVSQSIEHDHAHSL----EFLRRDIVNVNMYFKKKNVIT 27105_Tthe_RIO2 LMVED---------NGKVIMIDFPQMVSTKHKNAQ----FYFDRDVECIHVFFERRFNYQ RIO1_Spur_RIO1 MLYCQ----------DKLYIIDVSQSVEHDHPSAL----EFLRKDCTNVTEYFRKNGVCT RIO2_Spur_RIO2 LMLDDQ---------DQITLIDFPQMVSTSHENAE----WYFNRDVQCVVDFFNRRFNYK RIO3_Spur_RIO3 ------------------------------------------------------------ CC1G_04984_Ccin_RIO1 ILYHE----------GRLCIIDVSQSVEHDHPSAF----DFLRSDIKNVEEFFGKGGVQT CC1G_13652_Ccin_RIO2 ILIREE--------TGEPVVIDFPQMVSTSHENAE----WYFNRDVECIRTFFRRRFRYE AqueK049_Aque_RIO1 MLYDTA--------NGCLYIIDVSQSVEHDHPHAL----EFLRKDCTNVTEFFRKKGIAV AqueK050_Aque_RIO2 IIISDE---------DKPTLIDFPQMVSTSHPDAARYTINYFERDVHCVAEFFSKRFQWR AqueK051_Aque_RIO3 MLWF----------EGRVYIIDVSQSVEPSHPHGL----EFLLRDCKNVSTYFSKKGLAE RIO1-2_Smoe_RIO1 VLYHE----------GHLYIIDVSQSVDLDHPRAL----DFLRQDCVHVNDFFKKGGVAV RIO1-1_Smoe_RIO1 VLYHE----------GHLYIIDVSQSVDLDHPRAL----DFLRQDCVHVNDFFKKGGVAV RIO2-2_Smoe_RIO2 LLIDDD---------EKVTMIDFPQMVSISHRNAE----SYFDRDVDCIYKFFLKRFNYV RIO2-1_Smoe_RIO2 LLIDDD---------EKVTMIDFPQMVSISHRNAE----SYFDRDVDCIYKFFLKRFNYV GK011_Glam_RIO2 AIVQTSDPENCTPETTRVVIIDFPQVIQSIAPEAE----EQFNRDVMSVEGFFNRRFGAD GK010_Glam_RIO1 LLYLN----------KKLYLIDMGQSVHVTHPNAL----QFLRIDIININFFFARQGIPV RIOK3_Hsap_RIO3 ALSE-----------------RELFN-AVS--GL-------N---ITAD----------- RIOK2_Hsap_RIO2 S-EL-----------------FPTFK-DIRR-ED-------TLDV----EVSA-S--GYT RIOK1_Hsap_RIO1 -MTV-----------------RELFE-FVT--DP-------S---ITHE----------- CG11660_Dmel_RIO1 -MTV-----------------KELFD-FIT--DQ-------T---ITTE----------- CG11859_Dmel_RIO2 S-ED-----------------YPKFS-DLVR-ED-------DLDA----EVHC-TGYGFT CG3008_Dmel_RIO3 IYTK-----------------EQLFE-FIT--GL-------N---SEV------------ M01B12.5_Cele_RIO1 -LSV-----------------RRLFE-VIV--DP-------L---MSSK----------- aSWK440_Cele_RIO2 S-ED-----------------WPKFD-EVER-KG-------NMDV----LLEA-S--GFT RIO2_Scer_RIO2 P-KPDSSMLDTEGFGDGYKYAYPDFKRDVKR-TD-------NLDE----LVQA-S--GFS RIO1_Scer_RIO1 -FPE-----------------RVIFQ-FVI--SE-------T---LEKF----------- RIOK1_Mmus_RIO1 -MTV-----------------RELFD-FVT--DP-------S---ITAD----------- RIOK2_Mmus_RIO2 S-EL-----------------YPTFS-DIRK-ED-------SLDV----EVSA-S--GYT RIOK3_Mmus_RIO3 ALNE-----------------RELFN-AVS--GL-------N---ISAD----------- ZK632.3_Cele_RIO3 LPTY-----------------VQLFN-LIT--DL-------D---MVED----------- Rio1_Ddis_RIO1 -MFI-----------------QELFE-FIT--DL-------T---ITED----------- Rio2_Ddis_RIO2 G-ER-----------------WPKFK-DCQN-IH-------SLDV----EISA-S--GFT 11147_Tthe_RIO1 -FSL-----------------RDIFD-FIT--DI-------N---IVPG----------- 27105_Tthe_RIO2 I-TD-----------------TLDFN-KIAR-LN-------DLDV----QVKA-S--GFI RIO1_Spur_RIO1 -MTM-----------------RELFE-FVT--DP-------N---ITED----------- RIO2_Spur_RIO2 S-EL-----------------YPKFS-DITC-EK-------TLDV----DVAA-S--GFS RIO3_Spur_RIO3 ------------------------------------------------------------ CC1G_04984_Ccin_RIO1 -LGI-----------------RKAFE-FVT--KE-------K---LSEE----------- CC1G_13652_Ccin_RIO2 S-NL-----------------YPRFK-RTMA-EGSADGNDFRLDV----IVEA-S--GFS AqueK049_Aque_RIO1 -MNV-----------------KSLFD-FVT--DG-------T---VTVD----------- AqueK050_Aque_RIO2 P-DEA----------------LPSLN-DIMK-VA-------SLDV----EVNA-S--GAI AqueK051_Aque_RIO3 TLSH-----------------QDLFN-KIT--GL-------G---ISAV----------- RIO1-2_Smoe_RIO1 -MTV-----------------RELFD-FIV--DP-------S---INDD----------- RIO1-1_Smoe_RIO1 -MTV-----------------RELFD-FIV--DP-------S---INDD----------- RIO2-2_Smoe_RIO2 P-GGNARTLQGIDNNVDEDDTRPDFE-NLARTAG-------ALDK----ELAA-S--GFT RIO2-1_Smoe_RIO2 P-GGNARTLQGIDNNVDEDDTRPDFV-NLARTAG-------ALDK----ELAA-S--GFT GK011_Glam_RIO2 I-V------------------LPRYN-EVMR-QI-------SEEELVGQRIDATE--AFV GK010_Glam_RIO1 -LSA-----------------REVLA-FIC--SP-------N---IPKT----------- RIOK3_Hsap_RIO3 -NEA-------------D-FLA-------------------------------------- RIOK2_Hsap_RIO2 KEMQADD--EL--LHPL------------------------------------------- RIOK1_Hsap_RIO1 -NMD-------------A-YLS-------------------------------------- CG11660_Dmel_RIO1 -NME-------------E-CLE-------------------------------------- CG11859_Dmel_RIO2 KEMEQDL--LEE----Y------------------------------------------- CG3008_Dmel_RIO3 -HTA-------------A-QLE-------------------------------------- M01B12.5_Cele_RIO1 -EME-------------T-IIE-------------------------------------- aSWK440_Cele_RIO2 KKMALDL--NKA-YDEGD-FLAHCEQ---------------------------------- RIO2_Scer_RIO2 KKHPGDRGLETA-VESM------------------------------------------- RIO1_Scer_RIO1 -KGD-------------YNNISALVAY--------------------------------- RIOK1_Mmus_RIO1 -NMD-------------A-YLE-------------------------------------- RIOK2_Mmus_RIO2 KEMQADD--EL--LHPV------------------------------------------- RIOK3_Mmus_RIO3 -NEA-------------D-FLA-------------------------------------- ZK632.3_Cele_RIO3 -HD----------------LLV-------------------------------------- Rio1_Ddis_RIO1 -NID-------------Q-YLE-------------------------------------- Rio2_Ddis_RIO2 RDMEKEF--QDL--SKQ------------------------------------------- 11147_Tthe_RIO1 -TEA-------------T-ILE-------------------------------------- 27105_Tthe_RIO2 KKEIKNI--DDFDIDLR------------------------------------------- RIO1_Spur_RIO1 -NIE-------------E-YLDEVIHKTCVSGDHGGPAPLLKDVNLSESKARELYLECIQ RIO2_Spur_RIO2 KEMEQSL--EEG-TDAL------------------------------------------- RIO3_Spur_RIO3 ------------------------------------------------------------ CC1G_04984_Ccin_RIO1 -NEG-------------M-SPEEVLQK--------------------------------- CC1G_13652_Ccin_RIO2 KNDMKVL--EEY-MEAA------------------------------------------- AqueK049_Aque_RIO1 -NID-------------Q-YIE-------------------------------------- AqueK050_Aque_RIO2 KEKSAGV--E-------------------------------------------------- AqueK051_Aque_RIO3 -DDQ-------------E-FLT-------------------------------------- RIO1-2_Smoe_RIO1 -QVE-------------T-YLH-------------------------------------- RIO1-1_Smoe_RIO1 -QVE-------------T-YLH-------------------------------------- RIO2-2_Smoe_RIO2 HQN--------------------------------------------------------- RIO2-1_Smoe_RIO2 HQN--------------------------------------------------------- GK011_Glam_RIO2 KEMVA------------------------------------------------------- GK010_Glam_RIO1 -DDM-------------YCRPANVV----------------------------------- RIOK3_Hsap_RIO3 ------------------------------------------------------------ RIOK2_Hsap_RIO2 ------------------------------------------------------------ RIOK1_Hsap_RIO1 ------------------------------------------------------------ CG11660_Dmel_RIO1 ------------------------------------------------------------ CG11859_Dmel_RIO2 ------------------------------------------------------------ CG3008_Dmel_RIO3 ------------------------------------------------------------ M01B12.5_Cele_RIO1 ------------------------------------------------------------ aSWK440_Cele_RIO2 ------------------------------------------------------------ RIO2_Scer_RIO2 ------------------------------------------------------------ RIO1_Scer_RIO1 ------------------------------------------------------------ RIOK1_Mmus_RIO1 ------------------------------------------------------------ RIOK2_Mmus_RIO2 ------------------------------------------------------------ RIOK3_Mmus_RIO3 ------------------------------------------------------------ ZK632.3_Cele_RIO3 ------------------------------------------------------------ Rio1_Ddis_RIO1 ------------------------------------------------------------ Rio2_Ddis_RIO2 ------------------------------------------------------------ 11147_Tthe_RIO1 ------------------------------------------------------------ 27105_Tthe_RIO2 ------------------------------------------------------------ RIO1_Spur_RIO1 QVRRIYQKAKLVHADLSEFNMLYCQDKLYIIDVSQSVEHDHPSALEFLRKDCTNVTEYFR RIO2_Spur_RIO2 ------------------------------------------------------------ RIO3_Spur_RIO3 ------------------------------------------------------------ CC1G_04984_Ccin_RIO1 ------------------------------------------------------------ CC1G_13652_Ccin_RIO2 ------------------------------------------------------------ AqueK049_Aque_RIO1 ------------------------------------------------------------ AqueK050_Aque_RIO2 ------------------------------------------------------------ AqueK051_Aque_RIO3 ------------------------------------------------------------ RIO1-2_Smoe_RIO1 ------------------------------------------------------------ RIO1-1_Smoe_RIO1 ------------------------------------------------------------ RIO2-2_Smoe_RIO2 ------------------------------------------------------------ RIO2-1_Smoe_RIO2 ------------------------------------------------------------ GK011_Glam_RIO2 ------------------------------------------------------------ GK010_Glam_RIO1 ------------------------------------------------------------ RIOK3_Hsap_RIO3 -------------------------------EIEALEK-M-----N-------------- RIOK2_Hsap_RIO2 ----------------------------------GPDD-KNI-----ETKEGSEFSF-SD RIOK1_Hsap_RIO1 -------------------------------KAMEIAS-Q----RTKE-E-RSSQDH-VD CG11660_Dmel_RIO1 -------------------------------RISERIK-D----RDFD-A-ISAQEK-ID CG11859_Dmel_RIO2 ----------------------------------GMVD------QADEEDEGEDLEEEEE CG3008_Dmel_RIO3 -------------------------------QIHTRGA-S----ISQA-T-APNQEE-CP M01B12.5_Cele_RIO1 -------------------------------EE-----------RV-----LV--NS-ED aSWK440_Cele_RIO2 -------------------------------ELRNRQE-ED---LGEDEDDSDDSKSME- RIO2_Scer_RIO2 ----------------------------------R--N-AVY--NSD-DDMSNDEAEEEN RIO1_Scer_RIO1 -----------------------------IASNL------------PI-K-STEQDE-AE RIOK1_Mmus_RIO1 -------------------------------KAMEIAS-Q----RTKE-E-KTSQDH-VD RIOK2_Mmus_RIO2 ----------------------------------GPDD-KIT-----ETEEDSDFTF-SD RIOK3_Mmus_RIO3 -------------------------------EIEALEK-M-----N-------------- ZK632.3_Cele_RIO3 -------------------------------QVEQFSE-E-----N----------R-SV Rio1_Ddis_RIO1 -------------------------------KMLEKIQ-S----RG---E-TTDEQK-IQ Rio2_Ddis_RIO2 ----------------------------------QDDD-EINNNDSDENDEDDDEDDDDD 11147_Tthe_RIO1 -------------------------------ELITK---E-----N-----KDT--E-QD 27105_Tthe_RIO2 ----------------------------------GSDD-D-----GD-DDNSDDENEQND RIO1_Spur_RIO1 KNGVCTMTMRELFEFVTDPNITEDNIEEYLDEAMEITS-R----KSTT-E-VTAQEE-VD RIO2_Spur_RIO2 ----------------------------------KMDG-D-C-----EDDETDEEDE-EE RIO3_Spur_RIO3 ------------------------------------------------------------ CC1G_04984_Ccin_RIO1 ----------------------------WLEEQRTSGGGD----EVEEEK-KAEIAA-HE CC1G_13652_Ccin_RIO2 ----------------------------------DLEE-EG---TGDEEDESEESEEEE- AqueK049_Aque_RIO1 -------------------------------EAQKRA--------IEE-K-GTNEDQ-VD AqueK050_Aque_RIO2 -----------------------------------------------EENEGEEEESKEF AqueK051_Aque_RIO3 -------------------------------QIRAYTQ-R-----Q----------Q-LL RIO1-2_Smoe_RIO1 -------------------------------EIQKRIE-E----RI-----SSTADD-VA RIO1-1_Smoe_RIO1 -------------------------------EIQKRIE-E----RI-----SSTADD-VA RIO2-2_Smoe_RIO2 ------------------------------------------------------------ RIO2-1_Smoe_RIO2 ------------------------------------------------------------ GK011_Glam_RIO2 ------------------------------------------------------------ GK010_Glam_RIO1 ----------------------------------EY---D----SMSP-R-NAP--S-LD RIOK3_Hsap_RIO3 ------------------------------------------------------------ RIOK2_Hsap_RIO2 -GEVA----------EKAEVYG--SENE--SER--NCLEE--SEGCYCRS--------SG RIOK1_Hsap_RIO1 -EEVF----------KRAYIPRTLNEVK--NYE--RDMDI--IM---KLKEEDMAMNAQ- CG11660_Dmel_RIO1 -EAVW----------QNTYIPKRLDEVR--HFE--RDVAK--AK---Q---------GV- CG11859_Dmel_RIO2 -PPTL----------VTA--AS--VEID--ECR--RQV-E--NEVIYS----------EA CG3008_Dmel_RIO3 -DE-----------------------LK--PLE--YPFEL--A----------------- M01B12.5_Cele_RIO1 -DSLF----------MNAFIPHKLEHVL--HFE--RDGKL--AK---EG---------V- aSWK440_Cele_RIO2 --DIQ----------EEPE------DLE--KD-----HEE--LQ---------------- RIO2_Scer_RIO2 ----G----------EG--------DYS-------------------------------- RIO1_Scer_RIO1 -DEIF----------RSLHLVRSLGGLE----E--RDFDR--YT---D---------GK- RIOK1_Mmus_RIO1 -EEVF----------KQAYIPRTLNEVK--NYE--RDVDI--MM---RLKEEDMALNTQ- RIOK2_Mmus_RIO2 -EEML----------EKAKVWR--SELE--KEA--DPADE--SGGSWCCS--------ST RIOK3_Mmus_RIO3 ------------------------------------------------------------ ZK632.3_Cele_RIO3 -DL-----------------------RH--DKS--RPAD--------------------- Rio1_Ddis_RIO1 -EEVF----------RNAYIPRTLDQII--DLD--RDMEK--IE---RG---------E- Rio2_Ddis_RIO2 -DENN----------DDDENND--NNIE--NEN--------------------------- 11147_Tthe_RIO1 -EKIF----------AGMYIPRTLNEVSFKNIE--ANIDKNILN---EG------SD-E- 27105_Tthe_RIO2 LDKNI----------EQ-EDSD--NEIE--ESN--KRI-----QNLNIL----------- RIO1_Spur_RIO1 -EEVF----------RQAFIPQKLEEVK--HYE--KEIVK--AK---E---------NK- RIO2_Spur_RIO2 -EGVV----------EEMKNPH--DGLQ--DSG--------------------------- RIO3_Spur_RIO3 ------------------------------------------------------------ CC1G_04984_Ccin_RIO1 -DEVF----------MKSYIPRTLNEVY--DPE--RDVDR--LT---R---------GE- CC1G_13652_Ccin_RIO2 ----E----------EEEE------E-E--EE-----GEE-------------------- AqueK049_Aque_RIO1 -DAVF----------KNIYIPQSLHEVS--RYE--SDVSE--AQ---T---------GS- AqueK050_Aque_RIO2 -ECSL----------AS----------------------H--VKGIHI------------ AqueK051_Aque_RIO3 -DV-----------------------IY--DKKEPYPFDF--F----------------- RIO1-2_Smoe_RIO1 -DAVF----------VQAFIPRTLDQVQ--DYE--RDIQR--IA---TG---------K- RIO1-1_Smoe_RIO1 -DAVF----------VQAFIPRTLDQVQ--DYE--RDIQR--IA---TG---------N- RIO2-2_Smoe_RIO2 ------------------------------------------------------------ RIO2-1_Smoe_RIO2 ------------------------------------------------------------ GK011_Glam_RIO2 ----------------K-YDPD--EEL--------------------------------- GK010_Glam_RIO1 -PKLTAYIRYLRAECARLYTPEEV------NGE--RDIVN--YP---------------- RIOK3_Hsap_RIO3 ------------------------------------------------------------ RIOK2_Hsap_RIO2 DPEQIKEDSLS-------EESADARS---FEMTEFN------------------------ RIOK1_Hsap_RIO1 -----------QD-NILYQTVTGLKKDLS-------GVQ--------------------- CG11660_Dmel_RIO1 -----------QQ-NLIYGKITGLTSDLD--------VQ--------------------- CG11859_Dmel_RIO2 KPTQKSDDAVR-------RYIESCT----QYLGNLSVGP--------------------- CG3008_Dmel_RIO3 -----------------WEK---------------------------------------- M01B12.5_Cele_RIO1 -----------EANN-PFQNIVS-KIDLK------------------------------- aSWK440_Cele_RIO2 ----AQENTVKQQ-KIVLSQTTRFTDWLSDATNQLE------------------------ RIO2_Scer_RIO2 ------------------------------------------------------------ RIO1_Scer_RIO1 -----------F--DL----LKSLIAHDN-------E----------------------- RIOK1_Mmus_RIO1 -----------QD-NILYQTVMGLKKDLS-------GVQ--------------------- RIOK2_Mmus_RIO2 DSKQIKDGGLP-------EESAHVSS---FEVTALS------------------------ RIOK3_Mmus_RIO3 ------------------------------------------------------------ ZK632.3_Cele_RIO3 ------------------------------------------------------------ Rio1_Ddis_RIO1 -----------GR-DIFYQNLTGLSKDLQ-------NIK--------------------- Rio2_Ddis_RIO2 ----------E-------ENIKKSSK---VNK---K------------------------ 11147_Tthe_RIO1 -----------EAKDIVYSKLTGLITKSN-------NQQNYESESDDDEDDDNEDENNSE 27105_Tthe_RIO2 NDEDISQDENE-------EEQKNNKK---Q------------------------------ RIO1_Spur_RIO1 -----------EH-EMYYKTITGLKGDLS-------GIQ--------------------- RIO2_Spur_RIO2 -----SEDKNS-------EEVQSIRE---DDTGGMS------------------------ RIO3_Spur_RIO3 ------------------------------------------------------------ CC1G_04984_Ccin_RIO1 -----------GK-QLIYAETIGVVAPAS-------A----------------------- CC1G_13652_Ccin_RIO2 ----SEEGG--------------------------------------------------- AqueK049_Aque_RIO1 -----------KT-DIAYQTITGLKPDLS-------GTL--------------------- AqueK050_Aque_RIO2 ----TDEDKLR-------ENVSEFDS--------IS------------------------ AqueK051_Aque_RIO3 -----------------FEETMN------------------------------------- RIO1-2_Smoe_RIO1 -----------DTEGIYYQTITGLKEDLS-------GVR--------------------- RIO1-1_Smoe_RIO1 -----------DTEGIYYQTITGLKEDLS-------GVR--------------------- RIO2-2_Smoe_RIO2 ------------------------------------------------------------ RIO2-1_Smoe_RIO2 ------------------------------------------------------------ GK011_Glam_RIO2 ------------------------------------------------------------ GK010_Glam_RIO1 ----------------VFESLSAITA---------------------------------- RIOK3_Hsap_RIO3 --------------------------------------------------------EDH- RIOK2_Hsap_RIO2 -----------------------------------------------QALEE-IK-GQVV RIOK1_Hsap_RIO1 -------------------------------------KVPA-------LLEN-Q------ CG11660_Dmel_RIO1 -------------------------------------QKPD-------VLQS-S------ CG11859_Dmel_RIO2 -------------------------------------EVPDQTMPKKLDISLPAETPDVI CG3008_Dmel_RIO3 -----------------------------------------------------SQ-QDRA M01B12.5_Cele_RIO1 ------------------------------------------------------------ aSWK440_Cele_RIO2 --------------------------------------------AVD--LD-------AL RIO2_Scer_RIO2 ------------------------------------------------------------ RIO1_Scer_RIO1 --------------------------------------------------RN-FA-ASEQ RIOK1_Mmus_RIO1 -------------------------------------KVPA-------LLES-E------ RIOK2_Mmus_RIO2 -----------------------------------------------QAVEE-ME-RQVL RIOK3_Mmus_RIO3 --------------------------------------------------------EDH- ZK632.3_Cele_RIO3 ------------------------------------------------------------ Rio1_Ddis_RIO1 -------------------------------------SKND-------LIND-SN----- Rio2_Ddis_RIO2 --------------------------------------------EVGKEIKK-EE-E--- 11147_Tthe_RIO1 DDTDKQIEAAKPNKFIKIVTKNEEDGGTEESKQKAQEEVSQ-------LLKQ-IQ-SNKQ 27105_Tthe_RIO2 -------------------------------------------------------KKHHL RIO1_Spur_RIO1 -------------------------------------EDPA-------LLED-RL-TGPG RIO2_Spur_RIO2 --------------------------------------------GVGQDNDD-QE-HCIM RIO3_Spur_RIO3 ------------------------------------------------------------ CC1G_04984_Ccin_RIO1 --------------------------------------------------EN-TA-GDKE CC1G_13652_Ccin_RIO2 ------------------------------------------------------------ AqueK049_Aque_RIO1 -------------------------------------LVPQ-------LLQN-GE-ENKS AqueK050_Aque_RIO2 --------------------------------------------SIP--LD-------EI AqueK051_Aque_RIO3 -----------------------------------------------------SR-QDNS RIO1-2_Smoe_RIO1 -------------------------------------QVPS-------LLEK-QE-KQPA RIO1-1_Smoe_RIO1 -------------------------------------KVPS-------LLEK-QE-KQPA RIO2-2_Smoe_RIO2 ------------------------------------------------------------ RIO2-1_Smoe_RIO2 ------------------------------------------------------------ GK011_Glam_RIO2 ------------------------------------------------------------ GK010_Glam_RIO1 ---------------------------------------TD-------YLDN-NY-ADYS RIOK3_Hsap_RIO3 -----------------------------------V-Q-KNGRKA--------AS----- RIOK2_Hsap_RIO2 ---------------ENN-SVTEF-SE-E--KNRTENYNRQDGQRVQGGVPAGS------ RIOK1_Hsap_RIO1 ------------------VEERTC-SD-S--EDIGSSE-CSDT-D--------SE----- CG11660_Dmel_RIO1 -----------------TAKEDDG-SE-A--QTSGSED-EDNSQD--------ND----- CG11859_Dmel_RIO2 PFE-----------AETSATNTVE-ED-V--KSISSN----------------D------ CG3008_Dmel_RIO3 AQKA------------LQQ-A----QD-N--NDNK-TD-TDKDQE--------TD----- M01B12.5_Cele_RIO1 ------------------GDG--F-GE----EHDDSDD-NDDEEN--------GK----- aSWK440_Cele_RIO2 KSE-----------EGYKDIELPP-ED-FKRPADSEND-DENDED--------EE----- RIO2_Scer_RIO2 -----------------------E-ED-E--YYDSELD-NE------------------- RIO1_Scer_RIO1 -FE------FDNADHECSSGTEEF-SD-D--EEDGSSG-SEED-D--------EE----- RIOK1_Mmus_RIO1 ------------------VKEETC-FG-S--DDAGGSE-CSDT-V--------SE----- RIOK2_Mmus_RIO2 ---------------PHR-SVTEF-SE-E--SRRTEND-GQPGQR----SPAGS------ RIOK3_Mmus_RIO3 -----------------------------------I-Q-KNGRKA--------AS----- ZK632.3_Cele_RIO3 ---------------------------------MEL-K----------------K----- Rio1_Ddis_RIO1 ---------------ENKD----S-DD-S--SSDSSED-SDDDSD--------SD----- Rio2_Ddis_RIO2 ---------------EN--NNSEE-ED-E--EEEEEE----------------D------ 11147_Tthe_RIO1 K-------------QEDDDSSLSSSSD-S--DSDDSED-SDEDED--------DE----- 27105_Tthe_RIO2 KKQ-----------SKSKSKKQNQ-EQ-E--GKDGE-----DDED----NQ--KNNFSPD RIO1_Spur_RIO1 QTQ----------GKG-EAGEEEE-ME-E--EEEEEEE-EDDEES--------GE----- RIO2_Spur_RIO2 ---------------V-M-DGNEQ-EQ-S--GKEKEN----------------H------ RIO3_Spur_RIO3 ------------------------------------------------------------ CC1G_04984_Ccin_RIO1 AAP------TYNPSQQ--TG-----TD-P--DKDGEEE-EGDE-D--------ED----- CC1G_13652_Ccin_RIO2 -------------------LSMPA-QRTYDGPSEGESR-QKT-----------SE----- AqueK049_Aque_RIO1 DFNNVRDQEINDLYQE-SANVDQE-SG-D--DSSQISN-TDDSSN--------DE----- AqueK050_Aque_RIO2 PLE-----------SEDKDYVNNK-ED-T---LEYISD-SEEYES--------S------ AqueK051_Aque_RIO3 GSIG----------VDVKRGK----KD-L--NESKSSE-SNEEEV--------LS----- RIO1-2_Smoe_RIO1 T-------------AEAETDQLVL-SG-A--ASSSSDS-SDQEGD--------SE----- RIO1-1_Smoe_RIO1 T-------------REAETEQLVL-SE-A--ASSSSDS-SDQEED--------SE----- RIO2-2_Smoe_RIO2 ------------------------------------------------------------ RIO2-1_Smoe_RIO2 ------------------------------------------------------------ GK011_Glam_RIO2 ----------------------------E--IKEGD-----EAVD----EC--SN----- GK010_Glam_RIO1 QLQ------ALNI--EL--YESDD-SD-S--EQSE-SD-QNSSEA--------NE----- RIOK3_Hsap_RIO3 ------------------FL-K------DD------------------------------ RIOK2_Hsap_RIO2 -------------------DEY------EDECPHLIALS---SLNREFRPFRDEENVGAM RIOK1_Hsap_RIO1 ------------------EQ--------GDHAR-P--------------------KKH-- CG11660_Dmel_RIO1 ------------------ND--------EDAKK-F--------------------KNSA- CG11859_Dmel_RIO2 -------------------LDT------DE-VPELVGLD---PNSRMYRLKMVEQMLNDA CG3008_Dmel_RIO3 ------------------DN-E------ND------------------------------ M01B12.5_Cele_RIO1 ------------------KSRKKRAEPTEEEIQ-E-----------K--E--RKIAMHT- aSWK440_Cele_RIO2 ------------------EGEE------EDADGHVA----------------VEEQVAKV RIO2_Scer_RIO2 -------------------SSE------DDS----------------------------- RIO1_Scer_RIO1 ------------------EGEY------YDDDE-P--------------------KVLK- RIOK1_Mmus_RIO1 ------------------EQ--------EDQAG-C--------------------RNH-- RIOK2_Mmus_RIO2 -------------------EDC------DDEPPHLIALS---SVNREFRPFRDEESMSSV RIOK3_Mmus_RIO3 ------------------FL-K------DD------------------------------ ZK632.3_Cele_RIO3 ------------------YN-E------EK------------------------------ Rio1_Ddis_RIO1 ------------------QLNE------DDEKI-R-----------K--LVVIDPITKM- Rio2_Ddis_RIO2 -------------------SDS------EESVE---DN----------TP-----VIEEF 11147_Tthe_RIO1 ------------------NDSD------DDDKQ-Q-----------D--S--EETKKKK- 27105_Tthe_RIO2 LSEISIEDLKELQKVNQDLFSD------DDNEDDPLALNEVKDINGNIVVP--EQKEKK- RIO1_Spur_RIO1 ------------------ED--------EEKTS-E--------------------RQHH- RIO2_Spur_RIO2 -------------------SDD------DDDLE---DIG---ASNKQYRPHRSEASMSKA RIO3_Spur_RIO3 ------------------------------------------------------------ CC1G_04984_Ccin_RIO1 ------------------GSEE------EDDDE-E------------------------- CC1G_13652_Ccin_RIO2 ------------------STQQ------EDGTPDIS----------------V------- AqueK049_Aque_RIO1 ------------------ESVS------GDCWE-E--------------------REK-- AqueK050_Aque_RIO2 -------------------SEG------EET----------------------------- AqueK051_Aque_RIO3 ------------------ET-E------EE------------------------------ RIO1-2_Smoe_RIO1 ------------------ED----------ET-------------------------NK- RIO1-1_Smoe_RIO1 ------------------EE----------DA-------------------------NK- RIO2-2_Smoe_RIO2 ------------------------------------------------------------ RIO2-1_Smoe_RIO2 ------------------------------------------------------------ GK011_Glam_RIO2 ------------------SMVD------DDADP-V--------------------DKSK- GK010_Glam_RIO1 ------------------EI--------EERER-------------N--L-----KMLS- RIOK3_Hsap_RIO3 ------------------------------------------------------------ RIOK2_Hsap_RIO2 NQY----RT--RTLSI---------------------TSSGSAVSCSTIPPELVKQK--V RIOK1_Hsap_RIO1 -----------T------------------------------------TDPDIDK-K--E CG11660_Dmel_RIO1 -------RP--R------------------------------------EESPESK-K--A CG11859_Dmel_RIO2 RS------Q------------------------------RSYSTTTSTIAPSVITDR--I CG3008_Dmel_RIO3 ------------------------------------------------------------ M01B12.5_Cele_RIO1 -------RN--R------------------------------------EETAEER-K--E aSWK440_Cele_RIO2 VK-----KK--RVPS----------------------GARSVASSAATFTAEDVKRR--L RIO2_Scer_RIO2 ------------------------------------------------------------ RIO1_Scer_RIO1 -------GK--K------------------------------------HEDKDLK-K--L RIOK1_Mmus_RIO1 -----------I------------------------------------ADPDIDK-K--E RIOK2_Mmus_RIO2 TRH----RT--RTLSV---------------------TSAGSALSCSTIPPELVKQK--V RIOK3_Mmus_RIO3 ------------------------------------------------------------ ZK632.3_Cele_RIO3 ------------------------------------------------------------ Rio1_Ddis_RIO1 -------EI--R-------------------------------------LEDMPK-K--D Rio2_Ddis_RIO2 KGLSLNK-----NRDFKFSNLKDEDQNAPIVLRKEFIEN--LD---ENQPTEP-K-K--E 11147_Tthe_RIO1 -------KGGDQ------------------------------------LYQGLSK-D--E 27105_Tthe_RIO2 -KP----KK--KMVD--------------------------IANEQDQDNKQDLKEKIYI RIO1_Spur_RIO1 -------RP--R------------------------------------DESPTAK-K--E RIO2_Spur_RIO2 NAHSLNARS--RNSDS---------------------I-SSYTSTSSTMNPALVRSK--V RIO3_Spur_RIO3 ------------------------------------------------------------ CC1G_04984_Ccin_RIO1 ---------------------------------------------------ED------- CC1G_13652_Ccin_RIO2 LN-----IS--RE------------------------SSRSA-SPEPDTVKDDIKAR--A AqueK049_Aque_RIO1 -------PS--K------------------------------------EEISRQR-K--E AqueK050_Aque_RIO2 -----------------------------------------------SIASKDLKKQ--V AqueK051_Aque_RIO3 ------------------------------------------------------------ RIO1-2_Smoe_RIO1 -------ES--R------------------------------------EERRSAR-K--E RIO1-1_Smoe_RIO1 -------ES--R------------------------------------EERRSAR-K--E RIO2-2_Smoe_RIO2 ------------------------------------------------------------ RIO2-1_Smoe_RIO2 ------------------------------------------------------------ GK011_Glam_RIO2 -EP----RM--RKV-------------------------------------VDIRQA--V GK010_Glam_RIO1 -------R---S------------------------------------DYSKEEW-R--E RIOK3_Hsap_RIO3 --------------------------------------------------------GD-P RIOK2_Hsap_RIO2 KR-QLTKQQKSA---------VRRRL---------QKGEANIFTKQRRENMQNIKSSLEA RIOK1_Hsap_RIO1 RK-KMVKEAQR----EKRKNKIPKHVKK------------------RKEK------TAK- CG11660_Dmel_RIO1 RK-KAVKDAKA----EQRKVKVKKHVKK------------------RKEK------M--- CG11859_Dmel_RIO2 RR-NMDIKEKR----EQRKKCV-------------AKGEASAVHRHRKENKDV----VKE CG3008_Dmel_RIO3 ----------S------------------------------------DDK------EK-I M01B12.5_Cele_RIO1 RK-AAVKEEKR----EQRKEKIPKHLKK------------------RA------------ aSWK440_Cele_RIO2 AL-DR-K---------RNKEKIRLKVKG---------K-QSAVGRNRKDNKD----V-IA RIO2_Scer_RIO2 -E-DAQ---------EEENERIIEALSSG------------------VENLKM---D-KL RIO1_Scer_RIO1 RK-QEAKDAKR----EKRKTKVKKHIKK------------------KL--------VK-- RIOK1_Mmus_RIO1 RK-KMVKEAQR----EKRKNKIPKHVKK------------------RKEK------TAK- RIOK2_Mmus_RIO2 KR-QLTRQQKAA---------ARRRL---------QKGEANVFTKQRRENMQNIKSSLEA RIOK3_Mmus_RIO3 --------------------------------------------------------GS-P ZK632.3_Cele_RIO3 ----------K------------------------------------ANR------GI-S Rio1_Ddis_RIO1 RK-KFVKEMNK----ERRKTKIPKHIKK------------------LTKK------RKAE Rio2_Ddis_RIO2 KV-ELTEEEKQRRKEEKRQKMITDKVKRQLGKTMREKVSVRNNVKSRTK-------KEVQ 11147_Tthe_RIO1 RK-KKVKEEKK----QKRENKIPKHIKK------------------QM-----------T 27105_Tthe_RIO2 KESELAEK---------AKAYIQRQVEKQ----FKQK--YKILKKNTK-SSN----SNKV RIO1_Spur_RIO1 RK-KAIKEEKR----ENRKNKVPKHIKK------------------RKEK------IAKE RIO2_Spur_RIO2 RG-NLKKKQKAA---------VRHRLA--------RKGEASQTTAKRRENRDTVNQ---S RIO3_Spur_RIO3 ------------------------------------------------------------ CC1G_04984_Ccin_RIO1 QK-RF-----------EKKPRGHRHEDK------------------EAK-------KV-- CC1G_13652_Ccin_RIO2 AA-EVSKRQNQ----QRRKYHSKKSVRN---------A-G--RPQGSKGKQD----TRVK AqueK049_Aque_RIO1 HK-ETVKKEKR----EKRKNKIPKHIKK------------------RKEK------VAR- AqueK050_Aque_RIO2 KK-TTLKKHHAH---------LKQSSKK-----SQR--KLPTSSGRRGQKGNR---LKIR AqueK051_Aque_RIO3 --------------------------------------------------------TD-S RIO1-2_Smoe_RIO1 HK-KKVKEEQR----EARKTKTPKAVKK------------------RKKK------VA-Q RIO1-1_Smoe_RIO1 HK-KKVKEEQR----EARKTKTPKAVKK------------------RKKK------VA-Q RIO2-2_Smoe_RIO2 ------------------------------------------------------------ RIO2-1_Smoe_RIO2 ------------------------------------------------------------ GK011_Glam_RIO2 QR-QLRKE---------QWRRIQH-------------------QRQSK-GTE----KHRD GK010_Glam_RIO1 IQ-KEVKRDAQ----ERRTKKIPKSVKK------------------RAEL------LA-- RIOK3_Hsap_RIO3 PLLYDE RIOK2_Hsap_RIO2 ASFWGE RIOK1_Hsap_RIO1 -TKKGK CG11660_Dmel_RIO1 -GSMKK CG11859_Dmel_RIO2 YAGWDF CG3008_Dmel_RIO3 NKTANH M01B12.5_Cele_RIO1 HRQHMK aSWK440_Cele_RIO2 EYAGWI RIO2_Scer_RIO2 GNYILE RIO1_Scer_RIO1 KTKSKK RIOK1_Mmus_RIO1 -AKKGK RIOK2_Mmus_RIO2 ASFWGD RIOK3_Mmus_RIO3 PVLSAD ZK632.3_Cele_RIO3 PAREYN Rio1_Ddis_RIO1 KFGKKK Rio2_Ddis_RIO2 AHISSY 11147_Tthe_RIO1 KKNKKK 27105_Tthe_RIO2 LASEYM RIO1_Spur_RIO1 HKSTKK RIO2_Spur_RIO2 LGSIWS RIO3_Spur_RIO3 --LEVR CC1G_04984_Ccin_RIO1 RASSSN CC1G_13652_Ccin_RIO2 LDSFWA AqueK049_Aque_RIO1 QKQSKK AqueK050_Aque_RIO2 QALSDW AqueK051_Aque_RIO3 DSTDED RIO1-2_Smoe_RIO1 DKKRKH RIO1-1_Smoe_RIO1 DKKRKH RIO2-2_Smoe_RIO2 QEDLDQ RIO2-1_Smoe_RIO2 QEDLDQ GK011_Glam_RIO2 NYRRDL GK010_Glam_RIO1 -RRRRA