CLUSTAL W (1.83) multiple sequence alignment RTKE1_Mbre MMHSPR------------------GWLALVVIVLGCVCARAQLITQGCPMHLLEARETQ- RTKE2_Mbre MYRVTF------------------WILAALTVAL-------AADAPGCPVHLLVAKNVYT RTKE3_Mbre MGKGKA---------------VVTPLLAAVLFGL------WHHAASDCPIRLLGFRDHLI RTKE5_Mbre MQRVLAE---------------CGSLLAS------------------------------- RTKE4_Mbre MAGAAAPAPLFDRRRSLPLLLLLLLLLLLLLISL------FSGAVATCPVVP-------- * * RTKE1_Mbre HFS-----CFNCTN--DLIALRYVPHYTVCTLKPAYEVDPICKRRVFWTRFVC----MSN RTKE2_Mbre TPE-----CFDCSDLQDQNGIKLASINSTCILNPNEGSD--CLSKFWWTHYDC----HPK RTKE3_Mbre -PVEFGPLKTDCGRY----WEDSVPVGTVCSFDKSY-------RYMFWTHFRC----IED RTKE5_Mbre -----------------------GIASASLTPDVGSIVI--DGVD-AWNG-TSVTIDLPF RTKE4_Mbre --PRFD--GQTCSGS----LETLAMCNVTCSPDVPLSLQ--CQGD-TWTG-SC----LPS . *. . RTKE1_Mbre NMFELDSS-GNI-----------------SDVYARAG-------CQVSFNAS-------- RTKE2_Mbre GYFLLNRVFGQL-----------------NEVYANAG-------CEVTFDAE-------- RTKE3_Mbre STFVLDEA-GNM-----------------TSRFEQAG-------CTIRGSF--------- RTKE5_Mbre PATLASIT-AQNGPDGEYEALSIELFSGASSVLSLTG-------------------ILLH RTKE4_Mbre SALRNCRP-HQILPRGEYD------WYCSNAQAIPRGLAWDITSFAVSFPPETEMSPRLD : . * RTKE1_Mbre ----D--ASVSLICDGQTVAGEDKLSMMP---------------YGGAPSNLKNLIIR-- RTKE2_Mbre ----D--GRPSLICDGAN--TANRFKIMP---------------RGGAPSDLKQLVIR-- RTKE3_Mbre ----D--DEPELICRGVPG-QENMLDRLA---------------DGGAPSNLVGIEAT-- RTKE5_Mbre NGSNT--KTVVAPVDFQDQAAVDRIVVQP---------------QAGTVN---------- RTKE4_Mbre RLANLTQLTVLTLFELTDKVSPSKLPELPALSFIELVDCVRAAPLYPVAPRLKGWSVRGL . : . . RTKE1_Mbre HHRLADIA--LPATHAFQLLQKLDLSHNRIN---------------FIGSPALVWLFE-- RTKE2_Mbre NHNLHKCH--RDNVVMFQQLERLDLSNNKLE---------------YVHELAAQSLYS-- RTKE3_Mbre HHNISYVA--HHNVHGYAKLRYLNLAHNTLV---------------RLGNFVFEPLVR-- RTKE5_Mbre -ASLRLDVAVICIADRYPADYSLNASGPNTFAL--SNSPNVAASLEASGSLGVQTLQLIA RTKE4_Mbre ESNLALNL--TILATRYPLLEYLRYSDNTIFDLVWAEVPPVFPHMRYLDSFWVQDMAS-- : . : * : . : RTKE1_Mbre ---------LKYLDLSYND-L----------------TSLRPA-----QLPFS------R RTKE2_Mbre ---------LKYLNLSHNL-L----------------SRLYAI-----HLPFE------N RTKE3_Mbre ---------LTHLNMSNND-F----------------AALDGT-----MLPSY------G RTKE5_Mbre SSAAAVQVTTPVLNHAFDFTRSRAYAVMLSTAAVSVGAQVDLEGTSPALTPASASLADTS RTKE4_Mbre ---------LRGLSLSFPH-LEY-----FQITAVTGPAQIDHT-----VLPQA------G *. : : : * RTKE1_Mbre RLQYMD-------LRGNPLTTLRTDILISSMAANCTA-----IYLP--SACGSPSPGRCD RTKE2_Mbre QLDTLD-------VRFNPIQEIRSDLLISAMSPNCSA-----IWLP--EACGLEALTDCT RTKE3_Mbre LLQMLD-------LTNNPVTKMDISIFDACFPRDCRQRPAYILKLPQSETCQWTLQNRCY RTKE5_Mbre AVQVLE-------FQFNAVVDT------------------A---------DFWLTL---D RTKE4_Mbre SLRTMLIGITSFDTQVRALAY-------------------D---------AWWRILNITD : : ..: RTKE1_Mbre QLLTPS----------GSTTTLDPATTTAVDLV--TTAAPTTP--DAPVCQLEDAAV--A RTKE2_Mbre ALLPVT----------APTP---------LPI---LTTNPSWNDNMATSCVVYEETL--N RTKE3_Mbre GPIEVQ----------GAT---------------------------NSSCRILNANR--A RTKE5_Mbre LTFSVASQVELVAVLLLDD----PL-------NCS-IEYGTFD--DAGTCRFCDG----- RTKE4_Mbre LLLTPP----------DED----PITIASSDLTCIGMVNPTAV--LALHCNCYDPPYSGA : * : RTKE1_Mbre ----------MTC-PDASAQISSWQYCDG-----------------QQDCADGWDEHD-- RTKE2_Mbre ----------LTC-SDNSNTITNFQYCDG-----------------VQDCDNGWDEFE-- RTKE3_Mbre P---------APCLNDRSVTFETHQFCDG-----------------YRHCADGSDEFM-- RTKE5_Mbre -------TTDFSD-TLGANTCQTVTTCDGGNTYETMAPTISSDRVCAQFCASGATDHDDN RTKE4_Mbre PFCPPPVMPRLSCLSAPNVHLDPTEICDG-----------------TAQCPDGEDEAG-- . *** * .* : RTKE1_Mbre -------CSQ-RWLTARSSLLEPCSDGVLSM----------------------------- RTKE2_Mbre -------CCQ-LWETSNIDFLGGCSDGELRL----------------------------- RTKE3_Mbre -------CEP-PAIYTEAALIGACVNNYLKF----------------------------- RTKE5_Mbre ATTPCETCAPGSYINPASPASGPCSDFICAAGTVDDDANVSTPCVACAAGHYVPANATGN RTKE4_Mbre -------CRF-RIAFIDSQTITP------------------------------------- * RTKE1_Mbre -----------------------------------------TWHRGHA------------ RTKE2_Mbre -----------------------------------------RYQRGHA------------ RTKE3_Mbre -----------------------------------------FFLRGRA------------ RTKE5_Mbre CSLYICAAGEVDDDSDPSTPCIACAAGTYAPTGSVGPCTDFTCARGSKDLDGDPTTECEE RTKE4_Mbre ------------------------------------------------------------ RTKE1_Mbre ----------------------------------------------------LARPPNAN RTKE2_Mbre ----------------------------------------------------QLGPPDPT RTKE3_Mbre ----------------------------------------------------IMRAANLD RTKE5_Mbre CAAGTFDASATGSPEPLTECAACAVGTFSDAPGATSCNTCDSCGTGEYVARGCILTENVI RTKE4_Mbre --------------EWPTF--ACLQ------------------GANMSVVRGVVRSDSQL . . RTKE1_Mbre -AMT-VCIPL---------LYTRWLAFAADTPE-----WNASASVHWVQELFDEPDGLF- RTKE2_Mbre -FVAYDCYEF---------FRVRYTTATLDTMA----ITNDSTRIYWAPSLESSDGDLQ- RTKE3_Mbre -AVAGTCVNS---------HYRQLQVSGFDPMV---NVSKDYVRLVWNIQIEEAVDVLAH RTKE5_Mbre CASCSSCAEGDPVVTACTAYADTLCQSTLDAAT---NKSTNGDKMPLGIVLGVVAA---- RTKE4_Mbre -ALNQSCYEW---------HG-------CSSMILNRDASAPYVYISATARDHRQLNTDAN * .. : RTKE1_Mbre FVVSIDRSRIRIDGSVQGSVIVDTLNF-VPAPTN-----VP--------TTTSRP---AA RTKE2_Mbre INTTLYRDELQL------TAEDDTTSFAFPAPIN-----SSNSINCDARTTIATT---AE RTKE3_Mbre LTVDLERYVHVMLGEF------D----------------LGDDIIIYANQTQQTT-RVGN RTKE5_Mbre IFVTLF-VVHFVHY----------------------RHRHGSETGVLPSVSR-QGSRGHV RTKE4_Mbre ITGTYRVVEGNMLG---IAGSPAQTSDVLPARQTPEEFAAAYDALIYHPTTSSSTTPFGS : : : RTKE1_Mbre SSTTAPV----------------------------------------------------- RTKE2_Mbre LTTIATT----------------------------------------------------- RTKE3_Mbre TLTTAPL----------------------------------------------------- RTKE5_Mbre YLASSDVPPAGPTRPGSANPNFMRPDPEVNRAPSSRRLSIVPLDEVRVRLQAGSKLGFSS RTKE4_Mbre LSSVAP------------------------------------------------------ : : RTKE1_Mbre IAEARASRS----ALPVIAAAIAAAV--VLVGIIIWVAVRTRRNR-DTQVPEDYETEALQ RTKE2_Mbre -EASLVSRSSS--GMVVIASAMGAGLGLLVLGIIIFMCS--RRVKLDRPVWA-LEA-SAA RTKE3_Mbre -PEGIPSRSHRDDILPIVGAVVGTMI--VIGAIVAVFAFRNR------------------ RTKE5_Mbre RRAGSVKRAASS-LLRLVCAQKCASVR---R--------------AYGFL---------- RTKE4_Mbre QATGSQSRASTI-LLVVIV----------------------------------------- . .*: : :: RTKE1_Mbre LFISSYPRAARDVPHLSAEWSALTARPGLWTANGTTRVLEHQP-FAQHYMLAATSPTMHV RTKE2_Mbre VFARQYARVAQKSTELTSQLAAMTVSAREVTLKRQASIFATLP-FDQGFMTLSSTRKCYS RTKE3_Mbre ------------------------------------------------------------ RTKE5_Mbre --------GVRVIAWLDPSCAATTRQEGGWRAERETMLIALGRLVVADFRVLGASMRMP- RTKE4_Mbre -------------------------------------------IVVLVSLSLGA------ RTKE1_Mbre ALALPRTTATV-EEEHAVLSALVEARILLTMKDHPNVL---------------------- RTKE2_Mbre GVYLPAFPTT--EEQPNVERALVEARLLLCLQQHANVL---------------------- RTKE3_Mbre -------------------------RRLNCLHQHRHIL---------------------- RTKE5_Mbre SCSQPAFPRRVSPDHKGVLGVLLLLCLAMVMAQQPQLFIKNECPDSCSPDASVTLGYNGF RTKE4_Mbre ------------------------------------------------------------ RTKE1_Mbre -------------------------------------HLVNVIHERQNIMLVYEPARLGV RTKE2_Mbre -------------------------------------KVHHLASDDRVQILLYEEIQQGP RTKE3_Mbre -------------------------------------NFAGYSTMKDGFILIYDMSNYTQ RTKE5_Mbre TGSHIARPRADQWATWAINVSTDRLELCCIDFQSWTPALMGSYTNTD--YLVLDMLEQPS RTKE4_Mbre ----------------AGFLWFNRRT---------------------------------- RTKE1_Mbre LSQAL-SSTSVSREQQQ---------------------AIC-GQVASACSYLESL--GIV RTKE2_Mbre LDVAL-AQYKVTQAQGR---------------------EIC-LKVASACSFLESM--GIV RTKE3_Mbre LADVL-RLDAPNPKESA---------------------LICQRQVAEACSFLDSL--GIV RTKE5_Mbre ADLMSWIQTQRPKNLGIQWRDQRPATLDWAQLPWQKLRNLA-LGFFYKVSFGEDTFIPIG RTKE4_Mbre ---EA-SQVKVSVQANI---------------------RFL-RQLAAGLSFLEDL--KLI : . *: :. : RTKE1_Mbre HRNLGAHSVYACQSIDDVRLAGFVMAKDVYLTQEYVATVSKGRAKL-------------- RTKE2_Mbre HRNLGAHSIYACSDITDVRLAGFGLSRDVYFTEEYMTKNAA-ASQL-------------- RTKE3_Mbre HRNLGAHSVFCVGDITEVRLANITTARDVYLSQEYVARTIVNEATMASA----TAMGSSD RTKE5_Mbre QDGLLQHCGLL-ATQPDNALNLSAMARDVYETQSYIQTNKLNRDGADKMDTWADGVGSSL RTKE4_Mbre HGRVCTESVLVMNNAPLVKLFGFATP--TVPDQEDLAIKPESHTIVP------------- : : .. * . . :. : RTKE1_Mbre -------TPDRYFWSPEVWRDSVFSFKSDVYAFGRFCWQVCHGGQIPYADMSPTNFVQQS RTKE2_Mbre -------APDRRFWSPEVWQDGNFSFKSDVFAFGRFFWQVYNNGQMPYKEMPERQFVSAS RTKE3_Mbre THDEFSKQLAKRFWSAEVWSDQIFSTKSDVYAYGQLCWQVYNKGQLPYPGMSLQSIALHV RTKE5_Mbre GLLGATQAEKLRFLSPEALDDNHFSSSSDVFAFGVLLWEVLLAET-MFKGESRPRIAQRI RTKE4_Mbre -VWDPATWGSTRYFAPELLLCPHPTNPGDVFSYGALMYEVMANGTPIFAGLDGQQVLMRQ : :.* : .**:::* : ::* : . RTKE1_Mbre VNGSLPDLPPTEN-EFLEDLIKSCTQLAVKARPTFATLAAALWEDDIDVLE-PALMQR-- RTKE2_Mbre VTNALPALPVVED-PLAQRLIEACLRTQPRSRPRFGYDTKLTLRCLTGLLI--SQLYRSP RTKE3_Mbre QQGTPPSVRAIPS-EHARRLILQCLRIKPESRPNFACVAFEVERCSLDRLD--AVMART- RTKE5_Mbre RTHNMPALPVKYS-TFAD-VYSHLVDRVPARRPSFDNLYFMLLNAETP----ESGYL--P RTKE4_Mbre RQAQLPPLPQTHNLPAATALYTECIAADPKERPAFRSIYQQLLQCEWAFEHEEKLSF--P * : . : ** * . RTKE1_Mbre NVPEIAVSRLNQMDGLEKVYDV-DGQL-MESI--AYGPTD----AVL-RELSFRVKLDSE RTKE2_Mbre HACALILICYAFHSALVAALQE-ENAYMAVDA--TMVPTQ----LV---RIAVDRKLDCI RTKE3_Mbre ---------------------------------------R---------------HIFHE RTKE5_Mbre QLAVATIRPTWSTTDLIAGTATIDDARLAGSPVTCFIPRKANSDAHWTTQFHLLLQLPHD RTKE4_Mbre NLPVQVRRRRALASGFDAVQVVTNAAQLSHTSLVALVRRDQ-DSATWTNSCRLANQLRHP :: RTKE1_Mbre GLPAVLGT---VTF-GQNTMLLAEYLAVPMA--SQLNAELDGEMAFR-WLRTVLGTLEYL RTKE2_Mbre ALPMLRAVAE-SSN-GEELVL-VDSYVTPLT--AHLNASVPVETGQR-WLEEVMVGLEYL RTKE3_Mbre HLQMPVAH---TRV-GNQASILAPFASTSLTDYLQLHANMDLDTALG-LCRNALEAVEYL RTKE5_Mbre GLVQVLSVTECTLEGARRPCLVVP-PCAPYA--SADPPLPAAQ-VVKELALDVLIVLEYL RTKE4_Mbre HQQFVISHTRLYGDEGWEEALVVQ--DFPIL--TQLAPTPAVFRLRQWLCAQLLSWLDYM . . . : . . . : ::*: RTKE1_Mbre SSRNIHFMTVQLEDCRLTSTNQAKICN---CPFRPSS-----------------DG---- RTKE2_Mbre ASRHLYFTDFTVDNCYLDEEERVRLRN---CPLQPSSA----------------ES---- RTKE3_Mbre ASRRVLLEDLRVGDFRVTRHGVLKLDYGRQWGLTGLGASAEDNASRRSDSVS-TGGGGGG RTKE5_Mbre AARQCAPRDIRLEHCVVLE-GRIGLVG---LALANVGASLGLLENYLSFLRE-ARGGLVA RTKE4_Mbre AHRGLAVSGLSLSCCRVGA-GLLKVSG---MHIKHVPELAQAFREALAQLQGVIREAGVA : * . : : : : RTKE1_Mbre ------GGEASVAKAAGGLILDMCQFVPTID-SPELRQLGEVMKRGRLKKCSDVMLAI-- RTKE2_Mbre ------TDEVAVVRAAGQFIIDFCAQLPALS-ESGLPQLAEVMKRGRVKRCSDVILAI-- RTKE3_Mbre GGGGGALDEVVTVKAAGRFLVDLCELVAALRDQSELRQLGEVMRRGRVKKCGDGLLAL-- RTKE5_Mbre LNGNATLDRVIACVEAFMTRVDRYILPEAT--------TGDGLTRPQL--QSEALSA--- RTKE4_Mbre FGHAFASDRLVQ----------------------------DVVRRCDVVMGSQQLVADFR .. : : * : .: : * RTKE1_Mbre -------HAADPHRQLEVDADRLTFVRQLGEGEFGVVSLMTLLTTEG------------- RTKE2_Mbre -------LSTYRERQLDIPFAQLTFVRKLGEGEFGEVNLMSMANQYG------------- RTKE3_Mbre -------LSLDRQRRLELPYEQLTFVRALGQGEFGQVSLMTLREGG-------------- RTKE5_Mbre -LARELRDICQPNSSWNVPLSALQFVRVLGSGQFGEVWLASMPAHAHSSPNYSSKETAAA RTKE4_Mbre RLVVDVEELCNPQRNFYINYSRLKFVRNLGAGAFGEVMLMELEGIS-------------S . : * *** ** * ** * * : RTKE1_Mbre -----SRHVAVKTLHNMTFMEDFKSEVAMMIKLRHPNLVGLLHTTSFGAREPAMILEYMP RTKE2_Mbre ----STLQVAVKTLRDASLREDFMSEVTMMLKLHHPNLVGLLHTSQTTDGHLAMILEFMP RTKE3_Mbre ----STRQVAVKLLLEAQHHKEYVAEVTMLSKMHHPNLMGLVHTTVTAEGHPGMVLEYMP RTKE5_Mbre TSKREVMLVAVKRLLNDECLHEFEQELAIMMKIRHANLVRMLFVVQ-EKQHRALVLEYLD RTKE4_Mbre EDQRKQRLVAVKRLLDSEVKDEFVQEMTTMRKLKHANLVQLLHVVD-DDAHPGLVIEYLD **** * : .:: *:: : *::*.**: ::.. . .:::*:: RTKE1_Mbre GGSLETWLQERGRGTGPEDL-LYIAHQVTNGMAELARLGIVHRDLAARNVLVGRCL-NVK RTKE2_Mbre GGSLEGWLEDRGRSVSQTDL-IYIAHQVASGMAELARLGIVHRDLAARNVLIGRAL-NAK RTKE3_Mbre QGSLEGWLQARGTRVSHEDL-LLIAHQVAMGMNELARLGIVHRDLAARNVLIGRCL-NVK RTKE5_Mbre GGALDSWLQGQSKPPSEERT-RHILHSIACGMLELQRLGMVHRDLAARNVLCDAQMQVVK RTKE4_Mbre GGSLADWLDDHHARPLDTDLSIHVLHSIANGMAELVRCGVVHRDLAARNCSF-SWV-DIQ *:* **: : : *.:: ** ** * *:********* : : RTKE1_Mbre VADYGLSRTMTIGIASSESYYRIKTSRPLPIRWMAPSSILDQKVSTQTDVWSFGCLCYEI RTKE2_Mbre VADYGLSRTMAIGTESEECYYRIKTSRPMPVRWMAPSTIVDRKFTSESDVWSYGCLLCEM RTKE3_Mbre VADFGLSRVMQLGRDDSDAYYRIKTRQPMPLRWMAPESILSRKCDVRSDVWSYGCLCVEM RTKE5_Mbre VADYGLSRSTRVGKDDEQAYYKFKTRRPMPVRWMAPEVLKTQKFTVATDVFSFGVLVGEV RTKE4_Mbre VSDYGLSRATAVSHEGASEYYRIQTSRPLPLRWLAPEMLKDKMANEATDVYAYGVLMHEL *:*:**** :. . . **:::* :*:*:**:**. : : :**:::* * *: RTKE1_Mbre WSCGQIPFGNLSDPEVVQRLILAQQG-------------------QLREDEPVLASPASC RTKE2_Mbre WSAGEMPFNDLDDQQVVERLLAAYAG-------------------RVPENEPVLASPKSC RTKE3_Mbre WSGGELPYARLKDAEVLERLVAALQG-------------------HLKDGAVVLASPSRC RTKE5_Mbre LTQAELPLAHLNDESLMLRITDCVKS-------------------GGYGGRPLHAPPVKA RTKE4_Mbre FE-DDLPLAHLDDAAFMGLLVELSRKSSGLIRQRRSSLGSSGDHVEMQARAPAFEPPAHC ::* *.* .: : .* . RTKE1_Mbre PPMISALMQTCLTVNGELRPSFATLSRRTHPQ-EWQALLT-------------------- RTKE2_Mbre PPLIDALIQSCLTVNGELRPNFIVLRRRTLPQ-VRIF----------------------- RTKE3_Mbre PAGISDLIQSCLCINPELRLGFALLVQRTRPE-VSCAWC--------------------- RTKE5_Mbre PAWVSQIMVDCTLFDAAARPDFADLVVRLSPF-TFMASPTNAGRARTNTGASSMSSRRMT RTKE4_Mbre PPALASVMRWCIDLNPMHRPTFAQLQDKWVAVGVSQA----------------------- *. : :: * .: * * * : . RTKE1_Mbre ------------------------------------------------------------ RTKE2_Mbre ------------------------------------------------------------ RTKE3_Mbre ------------------------------------------------------------ RTKE5_Mbre GTISQSSGLGPGRHASVSSIASSLRSNSGGPVLGHSNEGHERHKLLSETHDSRPLPSDYY RTKE4_Mbre ------------------------------------------------------------ RTKE1_Mbre -----------------------------------------------------------R RTKE2_Mbre -----------------------------------------------------------G RTKE3_Mbre ------------------------------------------------------------ RTKE5_Mbre RANPVTELTMQSLRPPQQSTHAASQSETSPYLQPRGQSPSGANAYMRPQPLNLRGAPVSG RTKE4_Mbre ------------------------------------------------------------ RTKE1_Mbre TDTPKH-----------PLLASVSH----------------------------------- RTKE2_Mbre MGKPALLIYYFALTLLWHLLNSIGR----------------------------------- RTKE3_Mbre ------------------------------------------------------------ RTKE5_Mbre MAQPSPLMMQQLASRPSPYPQAAPRSGSPPTSPGPSPLSPSSQSPPPWSGQQYNQRGPAN RTKE4_Mbre AATPTALPAS----------Q--------------------------------------- RTKE1_Mbre ---------------------------------------------LFSG------LELE- RTKE2_Mbre ---------------------------------------------LWSAST-YPPPGFRD RTKE3_Mbre ----------------------------------------------FSFIQ-FTPV---C RTKE5_Mbre AYVQPRRLSGTGAEAVAGSTRLGSFSTSGPQHNQSATLSTGANAYLMPAFQHAPEMQLDT RTKE4_Mbre ---------------------------------------------ATPRLILSPSPTLED . RTKE1_Mbre --DNETCL RTKE2_Mbre M-SACTWT RTKE3_Mbre L-HHCTWL RTKE5_Mbre DAVDESHL RTKE4_Mbre TNQSESRL :