CLUSTAL W (1.83) multiple sequence alignment RET_Hsap MAKAT-------SGAAGLRLLLLLLLP--------------------------------- Ret_Dmel MESTT-------IV--FVTL-LTIITQ--------------------------------- RET_Mmus MAKAT-------SGAAGLGLKLILLLP--------------------------------- RET_Spur MLLHCYEIIKSLSTNNWYNLKEITFPTSFCEQNLVCVRHGLIKKSRRLQINNCRRKSSDK AqueK399_Aque MSETL-------C----------------------------------------------- AqueK400_Aque MFVTV-------D----------------------------------------------- AqueK401_Aque ------------------------------------------------------------ AqueK402_Aque SPT--------------------------------------------------------- RET_Hsap -LLG-KVALGLYFSRDAYWEKLYVDQAAGT-----PLLYVHALRDAPEEVP-SFRLGQHL Ret_Dmel -RKH-CAAVDVYFPTTSVKFNLPINEESESIFSKIPLAQFQVLRMED----------NRL RET_Mmus -LLG-EAPLGLYFSRDAYWERLYVDQPAGT-----PLLYVHALRDAPGEVP-SFRLGQHL RET_Spur KALGTVKGFQVYFPANQYMYSVPADFPLNRTIARVLALTRHAVNDARADISYSIRHDHHR AqueK399_Aque ------------------------------------------------------------ AqueK400_Aque ------------------------------------------------------------ AqueK401_Aque ------------------------------------------------------------ AqueK402_Aque ------------------------------------------------------------ RET_Hsap YGTYRTRLHENNWICIQEDTGLLYLNRSLD--------------------HSSWEKLSVR Ret_Dmel ASDYLYSLEQNPLLRINSSSGEIYMRTDYRSPNSSATFLVTA----FPRDQPDHELLNVS RET_Mmus YGVYRTRLHENDWIRINETTGLLYLNQSLD--------------------HSSWEQLSIR RET_Spur TAREDGGANLEKYFSINSTTGSLMLITNITGNDIRLPVRATAHLCGKVSEGSTWIRLKVR AqueK399_Aque ------------------------------------------------------------ AqueK400_Aque ------------------------------------------------------------ AqueK401_Aque ------------------------------------------------------------ AqueK402_Aque ------------------------------------------------------------ RET_Hsap NRGFPLLTVYLKVFLSPTSLREGE--CQWPGCARVYFSFFNTSFPACSSLKPRELCFPET Ret_Dmel HLS---LEVTPQPLEEYCSELEHI--CFWSS---------------------AQYTIAES RET_Mmus NGGFPLLTIFLQVFLGSTAQREGE--CHWPGCTRVYFSFINDTFPNCSSFKAQDLCIPET RET_Spur H-------------------REPSCMCRISS-----------------VMRIHESEFPTQ AqueK399_Aque ------------------------------------------------------------ AqueK400_Aque ------------------------------------------------------------ AqueK401_Aque ------------------------------------------------------------ AqueK402_Aque ------------------------------------------------------------ RET_Hsap RPSFRIRENRPPGTFHQFRLLPVQFLCPNISVAYRLLEGEGLPFRCAPDSLEVSTRWALD Ret_Dmel HGPYRRKDFFEPVLIGALNSRAAKYLCPHVSLEYSLNAGSS-HFV--LKQNRLYTRQTLD RET_Mmus AVSFRVRENRPPGTFYHFHMLPVQFLCPNISVKYSLLGGDSLPFRCDPDCLEVSTRWALD RET_Spur SLAFLYQPTGNPGSEVA---------------------GST-TFEISSASHRYGALCALA AqueK399_Aque ---------------------------PDIW----------------------------- AqueK400_Aque ---------------------------N-------------------------------- AqueK401_Aque ------------------------------------------------------------ AqueK402_Aque ------------------------------------------------------------ RET_Hsap REQREK-------YELVAVCTVHAGA-REEVVMVPFPVTVYDEDDSAPTFPAGVDTASAV Ret_Dmel HDELNGLNAKAGQLQARITCTVKLSSRDQRKFSRILDIKLLDRNDNGPKLQESSSKFDFY RET_Mmus RELREK-------YVLEALCIVAGPGANKETVTLSFPVTVYDEDDSAPTFSGGVGTASAV RET_Spur RRCNNS-------YC---SCPLH----------------------RAECFCSAIESTIA- AqueK399_Aque ----------------------------------SFVVKFLDSNQVTPGYRYDEGIKLP- AqueK400_Aque ------------------------------------------------------------ AqueK401_Aque ------------------------------------------------------------ AqueK402_Aque ------------------------------------------------------------ RET_Hsap VE---FKRKEDTVVATLRVFDADVVPASGELVRRYT---STLLPGDTWAQQ--------- Ret_Dmel LEQPYFQADEEA-GKKVIYVDKDTLEANAHLVYAVHNDSHGLFRPDCHAYE-----ADHT RET_Mmus VE---FKRKEGTVVATLQVFDADVVPASGELVRRYT---NTLLSGDSWAQQ--------- RET_Spur -------------CIRLSALDYASLYTTGDLVLNQT---IAHHQYRSWVRHAEVSIIGGE AqueK399_Aque ------------------------------------------------------------ AqueK400_Aque ------------------------------------------------------------ AqueK401_Aque ------------------------------------------------------------ AqueK402_Aque ------------------------------------------------------------ RET_Hsap ----TFRVEHWPNETSVQANGSFVRATVHDYRLV---LNRNLSISENRTMQLAVLVN--- Ret_Dmel GRPHTIVSCQLRFSR-----NGVFRETPYCVSL----EARDLTIV-SRVDA--------- RET_Mmus ----TFRVEHSPIETLVQVNNNSVRATMHNYKLI---LNRSLSISESRVLQLAVLVN--- RET_Spur VARETFGIRKGIVDG-----P-----EEHDKTLIEIYLLRTIPRDLSGPVEFVVRIDGHG AqueK399_Aque ------------------VCNN-------------------------------------- AqueK400_Aque ------------------------------------------------------------ AqueK401_Aque ------------------------------------------------------------ AqueK402_Aque ------------------------------------------------------------ RET_Hsap ---DSDFQGPGA-GVLLLHFNVSVLPVS-LHLPSTYSLSVSRRARRFAQIGKVCVENCQA Ret_Dmel -------MSATA-N-VCYHINLSKLHESEQELPQALP--LRARQHRIF--------ESEE RET_Mmus ---DSDFQGPGAGGILVLHFNVSVLPVT-LNLPRAYSFPVNKRARRYAQIGKVCVENCQE RET_Spur CGRHSNETARGG-RTLDIALNVTIWPVV-NYESTVYS----------------------- AqueK399_Aque ------------TAKLIDYLNL-------------------------------------- AqueK400_Aque ------------------------------------------------------------ AqueK401_Aque ------------------------------------------------------------ AqueK402_Aque ------------------------------------------------------------ RET_Hsap FSGINVQYKLHSSGANC------------------------------------STLGVVT Ret_Dmel FNGDSAGRSLSPPTVDYDKDVSVYRSAASNFRVVQPDSFLDLMRLRSIRFDIVEDKLGAF RET_Mmus FSGVSIQYKLQPSSINC------------------------------------TALGVVT RET_Spur -------------------------NITAGSRIVDLSSALST-SKRPLRFVNEEYWHSMF AqueK399_Aque -------------TSDC------------------------------------CSDGGIK AqueK400_Aque ------------------------------------------------------------ AqueK401_Aque ------------------------------------------------------------ AqueK402_Aque ------------------------------------------------------------ RET_Hsap SAEDTSGILFVNDTKALRRP--KCAELHYMVVATDQQTSRQAQAQLLVTVEGSYVAEEAG Ret_Dmel GITSTSGIVFVKNPQVLEEA-PE-TIYFLNVTWIDQQRLSHVRVINVHLVHGR--PENTS RET_Mmus SPEDTSGTLFVNDTEALRRP--ECTKLQYTVVATDRQTRRQTQASLVVTVEGTSITEEVG RET_Spur ELQETMGIVYVTNRTALRLIAPRNVTLYVECGSLGDVLNAGIIINLTITIE--------- AqueK399_Aque VPQPTKTTTKVINTSTTPVP--HSTTIQTT--------------------RSTPLIPAIG AqueK400_Aque ------------------------------------------------------------ AqueK401_Aque ------------------------------------------------------------ AqueK402_Aque ------------------------------------------------------------ RET_Hsap C-------PLSCAVSKRRLECEECGGLGSPTGRCEWRQGD-GKGITRNFSTCSPSTKTCP Ret_Dmel CELKVKSRSQTCAQIKYQSQCVRYCGLATGGGSCQWRGSN-SAMFGTRYGSCVPESRYCP RET_Mmus C-------PKSCAVNKRRPECEECGGLGSPTGRCEWRQGD-GKGITRNFSTCSPSTRTCP RET_Spur ------KTGDSCSRHRNRADCLTHCGMGSMHGHCSWRGGGMQRAMSTLYATCTPDVKTCP AqueK399_Aque T----------------------------PS----------------------------- AqueK400_Aque ------------------------------------------------------------ AqueK401_Aque ------------------------------------------------------------ AqueK402_Aque ------------------------------------------------------------ RET_Hsap DGHCDVVETQDIN-ICPQDCLRG-SIVGGHEPGE-PRGIKAGYGTCNCFPEEEKCFCEPE Ret_Dmel DHVCDPLEELNPM-ACPQDCTPAGRIVGPHSSNENKRGIYSASGTCIC-EDNGKCSCAPL RET_Mmus DGHCDAVESRDAN-ICPQDCLRA-DIVGGHERGE-RQGIKAGYGICNCFPDEKKCFCEPE RET_Spur DNRCDLVEMENRNDICPQDCTTIT-T-------------------------TKEPVPLQE AqueK399_Aque ------------------------------------------------------------ AqueK400_Aque ------------------------------------------------------------ AqueK401_Aque ------------------------------------------------------------ AqueK402_Aque ------------------------------------------------------------ RET_Hsap DIQ--------------------------------DP-----------LCDELCRT-VIA Ret_Dmel DEEPKMKKPRKRKNETEAEPLLGVRRGTPPNQPLQDPMLLGVLNVAGFECDRSCMFFVIT RET_Mmus DSQ--------------------------------GP-----------LCDALCRT-IIT RET_Spur DPG--------------------------------DE-----------LCGPECYL-GVC AqueK399_Aque -AS--------------------------------NQ-----------LTSALIPG-MIS AqueK400_Aque ------------------------------------------------------------ AqueK401_Aque ------------------------------------------------------------ AqueK402_Aque ------------------------------------------------------------ RET_Hsap AAVLFSF-IVSVLLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFPVSYSSSGARRPSLD Ret_Dmel CPLLFVLLLLCLLIAQR-KMLQRRLGKQSMTT-----------------SSKQALP---E RET_Mmus AA-LFSL-IISILLSIFCVCHHHKHGHKPPIASAEMTFCRPAQGFPISYSSSGTRRPSLD RET_Spur AGVFLTA-LITIILAVR-KRRARRHQRRAYTSSI---FKPPI-DAPNTTRASMVLA---E AqueK399_Aque ILLMLLV-VLAIVLSVACCVKKA--RNRKQLMNKEFSIKTNCSLLLKS------------ AqueK400_Aque ------------------------------------------------------------ AqueK401_Aque ------------------------------------------------------------ AqueK402_Aque ------------------------------------------------------------ RET_Hsap SMENQ-VSVDAFK----I-LEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGY Ret_Dmel SGG-GDFALMPLQSGFRFESGDAKWEFPREKLQLDTVLGEGEFGQVLKGFATEIAGLPGI RET_Mmus STENQ-VPVDSFK----I-PEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFRLKGRAGY RET_Spur YAD-EMTSGRSFGFKGRFE-QDSKWEFPLDKLLFEDELGEGHFGRVVRAQALSIRGHTGY AqueK399_Aque NKENIYFSDKTFEISSDYTNQLSKYIISGSSINVQETAGQGEFGIVYRGVMT--RENQMP AqueK400_Aque -------------FSSHLEQLLVKYSIPASQINLQEAVGQGEFGIVYRALLA--TGKDVP AqueK401_Aque ------------------------------------------------------------ AqueK402_Aque ----------------------------------------------------------VK RET_Hsap TTVAVKMLKEN-ASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPL--LLIVEYAKY Ret_Dmel TTVAVKMLKKG-SNSVEYMALLSEFQLLQEVSHPNVIKLLGACTSSEAP--LLIIEYARY RET_Mmus TTVAVKMLKEN-ASQSELRDLLSEFNLLKQVNHPHVIKLYGACSQDGPL--LLIVEYAKY RET_Spur TTVAVKMLKRDTATSAELHDLLTELELLKLLNHTNVIRLLGACIPKDPFETCVIVEYCKY AqueK399_Aque QPVAVKTLKGF-YSKSDVD----------------------------------------- AqueK400_Aque QVVAVKT----------------------------------------------------- AqueK401_Aque -----MALE--------------------------------------------------- AqueK402_Aque LPLKWMALE--------------------------------------------------- RET_Hsap GSLRGFLRESRKVGPGYLGSGGSRNSSSLD-------HPDERALTMGDLISFAWQISQGM Ret_Dmel GSLRSYLRLSRKIECAGVDFA---------------DG--VEPVNVKMVLTFAWQICKGM RET_Mmus GSLRGFLRDSRKIGPAYVSGGGSRNSSSLD-------HPDERVLTMGDLISFAWQISRGM RET_Spur GCLREFLRLNRKKA-LYTEYSISNESSSIPGLSRGKDVIKRFDIGFKEIASFAWQICKGM AqueK399_Aque ------------------------------------------------------------ AqueK400_Aque ------------------------------------------------------------ AqueK401_Aque ------------------------------------------------------------ AqueK402_Aque ------------------------------------------------------------ RET_Hsap QYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIES Ret_Dmel AYLSELKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDAYLKRSRDRVPVKWMAPES RET_Mmus QYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKKSKGRIPVKWMAIES RET_Spur HYISSLKVVHRDLAARNVLVAEGLLLKISDFGLTRDVYERGLYERQSKSLLPVKWMAVEA AqueK399_Aque -----------------------------------------------------------S AqueK400_Aque ------------------------------------------------------------ AqueK401_Aque -----------------------------------------------------------S AqueK402_Aque -----------------------------------------------------------S RET_Hsap LFDH---IYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDN--CS Ret_Dmel LADH---VYTSKSDVWSFGVLCWELITLGASPYPGIAPQNLWSLLKTGYRMDRPEN--CS RET_Mmus LFDH---IYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDN--CS RET_Spur LYDN---VFTVKSDVWSFGILLWEIVTMGAIPYPGVTAERLCQLLRDGYRMDRPEE--CS AqueK399_Aque LLDECIIMMSFDNLNWSYGVMCWEVFSLGRVPYPGLDPVGVVELLDTGGRLYTPNNEACS AqueK400_Aque --------LKEKSDIWSYGVLCWEVFNGGKTPFPGLDPAGVIELLDTGGRLNCPHNDACS AqueK401_Aque LHYG---IFSENSDVWSYGVLCWEVFSAGKIPYSGMDPTGLVELLDGGQRLSCPDNKACS AqueK402_Aque IHDG---LFSEKSDVWSYGVLCWEVFSLSRVPYPGLDPVGVVELLDTGGRLHTPNNEACS . .. **:*:: **:.. . *:.*: . : .** * *: *.: ** RET_Hsap EEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDG----- Ret_Dmel EAVYSIVRTCWADEPNGRPSFKFLASEFEKLLGNNAKYIDLETNAVSNPLYCGDDSALIT RET_Mmus EEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKSRDYLDLAASTPSDSLLYDDG----- RET_Spur EELF----------------------------VPQSEYLDLSDINGD-------L----- AqueK399_Aque KEIYSLMTSCWSESPDDRPVFSDLVSSINALIEPLAGYLDFADINSC---V--------- AqueK400_Aque DKIYELMLSCWLECPNDRPLFSEL------------------------------------ AqueK401_Aque EDIYSLMQQCWAESPDDRPLFSDLVASVNALIVPLASYLIVSNDSTF-Q-L--------- AqueK402_Aque KEIYSLMMSCWSESPDDRPVFSDLVSSINALIEPLAGYLDFTDINSC---V--------- . :: RET_Hsap ------------------------------LSEEETPLVDCNNAPLPRALPSTWIENKLY Ret_Dmel TELGEPESLQHLWSPPKIAYDIHDQATSYDQSEEEMPVTS--TAPPGYD----------- RET_Mmus ------------------------------LSEEETPLVDCNNAPLPRSLPSTWIENKLY RET_Spur --------------------------S---SDEENEEVVECHKEQ--CC----------- AqueK399_Aque ------------------------------------------------------------ AqueK400_Aque ------------------------------------------------------------ AqueK401_Aque ------------------------------------------------------------ AqueK402_Aque ------------------------------------------------------------ RET_Hsap GMSDPNWPGESPVPLTRADGTNTG-FPRYPNDSV-------------YANWMLSPSA--- Ret_Dmel ------------LPRPLLDATANGQVLRYENDLRFPLNIRKSSCTPSYSNMTSEPPATTS RET_Mmus GMSDPNWPGESPVPLTRADGTSTG-FPRYANDSV-------------YANWMVSPSA--- RET_Spur ------------LLRKNRDGEKSC-DPRGISHTA-------------SF----------- AqueK399_Aque ------------------------------------------------------------ AqueK400_Aque ------------------------------------------------------------ AqueK401_Aque ------------------------------------------------------------ AqueK402_Aque ------------------------------------------------------------ RET_Hsap --------------------AKLMD----------------------------------- Ret_Dmel LPHYSVPVKRGRSYLDMTNKSLIPDNLDSREFEKHLSKTISFRFSSLLNLSETKEVSPGW RET_Mmus --------------------AKLMD----------------------------------- RET_Spur -----------------------------------------------------------W AqueK399_Aque -----------------------EN----------------------------------- AqueK400_Aque ------------------------------------------------------------ AqueK401_Aque ----------------------NHD----------------------------------- AqueK402_Aque -----------------------EN----------------------------------- RET_Hsap --TFDS Ret_Dmel QAEDAV RET_Mmus --TFDS RET_Spur YIVSVL AqueK399_Aque --DIKA AqueK400_Aque ----NT AqueK401_Aque --HIYY AqueK402_Aque --DIKV