CLUSTAL W (1.83) multiple sequence alignment RYK_Hsap MRGAARLGRPGRSCLPGARGLRAPPPPPLLLLLALLPLLPAPGAAAAPAPRPPELQSASA lin-18_Cele M----------------------------------------------------------- drl_Dmel MAPNLLT----------------------IGLLL--TL-I-----------------ASG dnt_Dmel MSRKMWV----------------------LSLLALAALQLHS--------------GSEV Drl-2_Dmel MHKVCSAER-----ISGSNGVGVPS--K--LRGNFRFT-------------------SAV RYK_Mmus MRAGRG-------GVPGSGGLRAPPPPLLLLLLAMLPAA---------APRSPALAAAPA Ryk_Spur ------------------------------------------------------------ AqueK403_Aque MATKTSS----------------------CSS---------------------------- AqueK404_Aque MYE--------------------------------------------------------- AqueK405_Aque H----------------------------------------------------------- AqueK406_Aque MEKDIVR----------------------------------------------------- RYK_Hsap GPSVSLYLSEDE---------VRRLIGLDAELYY---VRND----LISHYALSFSLLVPS lin-18_Cele ------FISKEE---------MNRTFGVKAELNY---IEMG----NVSSYSTKFHYRVMA drl_Dmel QAHLNIFLNLHE---------VLRLIGVSAELYY---VREG----AINDYALNFAVPVPA dnt_Dmel AAHLNVFLNPVE---------VMRLLGVSAEVYY---VREG----HINNYALNFIVPVPA Drl-2_Dmel HPHPQLSLRPVG---------SFIPAGLEADLFY---VHEG----AINTYAMHFTVPVPA RYK_Mmus GPSVSLYLSEDE---------VRRLLGLDAELYY---VRND----LISHYALSFNLLVPS Ryk_Spur -------------------------MGVSAELYY---IREG----KINRAATNYPLAVPT AqueK403_Aque --SLSLFSSPLTIDQLIDVLDLLKRCGFPQTRWYELGLRLGLHKDTLDVLEAIFSDDIPR AqueK404_Aque ------------------------------------------------------------ AqueK405_Aque ------------------------------------------------------------ AqueK406_Aque -----------------------------KRLNY-------------------------- RYK_Hsap ETNFLHFTWHAK--SKVEYKLGFQV-DNVLAMDMPQVNISVQGEVPRTLSVFRVELSCTG lin-18_Cele NIDYLSFTWNAV--GIVHYEVYVES-DDSSVL--PIVRIPLKGTVPESLQDFTVEYRCAG drl_Dmel NISDVTFTWQSLVDHPLPYSINIAT-SDTEVLPRPILNISRIGDVPVEPQTWGIALKCSG dnt_Dmel NVKDISFTWQSLAGRGLPYSINVVS-SDQEVLPRPAINVSHSGEIPTTIQTWSIALKCSG Drl-2_Dmel DVHELEFSWQSLIAYPLPYAISIEYNNDQEALGTPTLSIPHKGLVPQEIESFLVYLPCTG RYK_Mmus ETNFLHFTWHAK--SKVEYKLGFQV-DNFVAMGMPQVNISAQGEVPRTLSVFRVELSCTG Ryk_Spur GINKLYYTWYSE--RQVYYSMSVKS-KSPRILYHPSLNITKDGKVPVKETVFEMQLECTG AqueK403_Aque CLTECISKWLR-----------------------RADNVDSKGGA--TFDSLSDALKS-- AqueK404_Aque ------------------------------------------------------------ AqueK405_Aque ------------------------------------------------------------ AqueK406_Aque -------EWKG--------------------------------D---------------- RYK_Hsap KVDSEVMILMQLNLTVNS-SKNFTVLNFKRRKMCYKKLEEV------KTSAL-------- lin-18_Cele HRSGQFAVSLYFTFKYG--NKEPLKVKLRQEKICASRDGRR------GLN---------- drl_Dmel TRNAEVTVTINVEVILDRATNNNTNLIFKRKKICLREEQDS------AHEEY-------- dnt_Dmel LKAAEVDVTVSLEVVLNRSLNNVTHLVFRRKKICLMNDSAE------DLSED-------- Drl-2_Dmel NASLQMPVNVNMVVRAPP-RFNDTRLHFKRNKICAKVDQSQ------PAS---------- RYK_Mmus KVDSEVMILMQLNLTVNS-SKNFTVLNFKRRKMCYKKLEEV------KTSAL-------- Ryk_Spur HEGGEAIIELQVNLTLYS-ASNITTLNTIRTKLCQGTESKV------KA----------- AqueK403_Aque ------------------MNENAAADKLDQEKRNAMISGNDIKGTNDVH-STATDDRPTV AqueK404_Aque ------------------------------------------------------------ AqueK405_Aque ------------------------------------------------------------ AqueK406_Aque -----------------------------------------NEGS--------------- RYK_Hsap -----------------------------------DKNT--------------------- lin-18_Cele ------------------------------------GGY--------------------- drl_Dmel -----------------------------------DDDDLDLLQTARKGHGGDIHYVDRN dnt_Dmel -----------------------------------V-D---------------------- Drl-2_Dmel ------------------------------------QGS--------------------- RYK_Mmus -----------------------------------DKNT--------------------- Ryk_Spur ------------------------------------------------------------ AqueK403_Aque SELIEFHELLIKGQLEESLPLLDADTIRKIRNAASDCEGISLLRQAFEEHPALLHEMRVV AqueK404_Aque ------------------------------------------------------------ AqueK405_Aque ------------------------------------------------------------ AqueK406_Aque ----------------------------------------------------PDHDLYLI RYK_Hsap -------------------------------SR----TIYDPVH----AAPTTS-TRV-F lin-18_Cele -------------------------------E---------GHE----VDDTDSIDKA-F drl_Dmel DEHVVANGHQAPEKQRPVVTESPVGRGNSGGSK----RDFDPMLRENLVPPASG-LVT-L dnt_Dmel ----------------------------------------DPQLLETVMLPPTG-LIT-L Drl-2_Dmel -------------------------------P----------RP----LSHPTR-RDS-F RYK_Mmus -------------------------------SR----TIYDPVH----AAPTTS-TRV-F Ryk_Spur ---------------------------------------------------VTS-TSV-F AqueK403_Aque TEKIIGSS-QKTLKSPPPVAHKPKSVSQSGQSQPLPTTKVPQSLLQTVQPPPAA-LK-PC AqueK404_Aque ------------------------------------------------------------ AqueK405_Aque ------------------------------------------------------------ AqueK406_Aque CD----------------------------STSNISSWRIP----------PNG-VENGI RYK_Hsap YISVGVCCAV--IFLVAIILAVLHLHSMKRIELDDSIS-AS-SSSQGL-SQP-STQ---- lin-18_Cele FVII--CIAA--AFL--LIVAATLICYFKRSKKEDMIP-TRLPTSFRN-SLK-STK---- drl_Dmel IVGGILALVL--VSTLILIAYCAKG-PSKR-HPSNGVHLIKTSSFQRLPT----IS---- dnt_Dmel VVGVSVAMGS--VCLLLMIAYCVKGAANKRQHHQHGGQPMRTSSFQRLNTHP-PCQ---- Drl-2_Dmel DDGVRYCCVL--IE-----FSLWAKSSSKRGSNS-----SSG-STTNT-I-----K---- RYK_Mmus YISVGVCCAV--IFLVAIILAVLHLHSMKRIELDDSIS-AS-SSSQGL-SQP-STQ---- Ryk_Spur YIAVGVVCGI--ILLFVLVVALIHVRTMRSSD---PAS-SD-ASSTGL-ING-GRQ---- AqueK403_Aque QSSTQLTPPVPKPRQKSLP-------------------ICTPGSPPAQSAQPPPVPPEHH AqueK404_Aque ------------------------------------------------------------ AqueK405_Aque ------------------------------------------------------------ AqueK406_Aque KMSLYVAPGY--VVNMSLP-------------------PLNVSTLPNSPSHPLPPP---- RYK_Hsap --TTQ-YLRADTPN---------------------------------------------- lin-18_Cele --SAQ-PFLLSTPR---------------------------------------------- drl_Dmel --STAHNSIYVCPS---------------------------------------------- dnt_Dmel --SSMGSAAYMTPS---------------------------------------------- Drl-2_Dmel ---------DKQQD---------------------------------------------- RYK_Mmus --TTQ-YLRADTPN---------------------------------------------- Ryk_Spur --PEH----PNFPK---------------------------------------------- AqueK403_Aque KKPFTEKLPIPKPRNKTGLLLQAQAFVTTPALPSPEYITMKKMLADLVDLLAGNPPVISQ AqueK404_Aque ------------------------------------------------------------ AqueK405_Aque ------------------------------------------------------------ AqueK406_Aque --PFTPFPPFPHPG---------------------------------------------- RYK_Hsap -----------------------------------------NATPI----------TSSL lin-18_Cele -----------------------------------------DGPPT----------LSAI drl_Dmel -----------------------------------------TITPT----------YAT- dnt_Dmel -----------------------------------------IIAPI----------HGSS Drl-2_Dmel -----------------------------------------LSTPKSIRSNGNGNCTSGS RYK_Mmus -----------------------------------------NATPI----------TSSS Ryk_Spur -----------------------------------------IPEPKVDR-L-----SNGN AqueK403_Aque LNNHLFSSDLIPKAVHVTVESTGLSPYDRSNKIFSSVLATLECHPN----------PNSV AqueK404_Aque ------------------------------------------------------------ AqueK405_Aque ------------------------------------------------------------ AqueK406_Aque -----------------------------------------VRHPS----------MGSI RYK_Hsap GYPTLRIEKN-----DLRSV-------------------------------------TLL lin-18_Cele SSAPCSSSSASGNSIIPSKP-------------------------------------RNI drl_Dmel ----L----T--RPFREYEH-------------------------------------EPE dnt_Dmel ----L----PRKVPVSVEQQ-------------------------------------HPE Drl-2_Dmel GSLSLFGGIPTGSTITM-AS-------------------------------------HGE RYK_Mmus GYPTLRIEKN-----DLRSV-------------------------------------TLL Ryk_Spur GYNSLHYQI------CPSLA-------------------------------------EAE AqueK403_Aque -----------------FSSLITSLQKVGLKNMASKLRGNLSKIEVTTAVVRPVSSST-V AqueK404_Aque ------------------------------------------------------------ AqueK405_Aque ------------------------------------------------------------ AqueK406_Aque -----------------LNS-------------------------------------S-I RYK_Hsap EAK--------------------------------------------------------- lin-18_Cele DVR--------------------------------------------------------- drl_Dmel EFN--------------------------------------------------------- dnt_Dmel ELH--------------------------------------------------------- Drl-2_Dmel KGN--------------------------------------------------------- RYK_Mmus EAK--------------------------------------------------------- Ryk_Spur DLR--------------------------------------------------------- AqueK403_Aque NQLPTANTTVSASNSELFFNAANQPMFDEIRGSFGILIAELVPLISQSIPSAAELKSFLQ AqueK404_Aque ------------------------------------------------------------ AqueK405_Aque ------------------------------------------------------------ AqueK406_Aque RSL--------------------------------------------------------- RYK_Hsap ----------------GKVKDI-AISRERITLKDVL------------------------ lin-18_Cele ----------------RALLQL-YQDRDAFQSLPLD------------------------ drl_Dmel ----------------RRLQEL-TVQKCRVRLSCLV------------------------ dnt_Dmel ----------------RRISEL-TVERCRVRLSSLL------------------------ Drl-2_Dmel ----------------QRLRRITSVQPGALSYEELV------------------------ RYK_Mmus ----------------AKVKDI-AISRERITLKDVL------------------------ Ryk_Spur ----------------LKLAPY-AIERSRITLGEVL------------------------ AqueK403_Aque LSFPELSPDLSNADSIEAIMNV-VVKKCRVNNISILKVIIKRFKITEAKPIISEYEEEVK AqueK404_Aque ------------------------------------------------------------ AqueK405_Aque ------------------------------------------------------------ AqueK406_Aque ----------------MSFRDI-FVDRKRIQFNAKL------------------------ RYK_Hsap -------------------------------------------QEGTFGR---------- lin-18_Cele -------------------------------------------MEGTFGE---------- drl_Dmel -------------------------------------------QEGNFGR---------- dnt_Dmel -------------------------------------------QEGTFGR---------- Drl-2_Dmel -------------------------------------------KEGTFGR---------- RYK_Mmus -------------------------------------------QEGTFGR---------- Ryk_Spur -------------------------------------------LEGTFGR---------- AqueK403_Aque TVSGSLKDFLSQNQPEHFHTCETIQFTLGWEPDEHSLHDIRNLLEEAFKKLNKRIIVRSI AqueK404_Aque ------------------------------------------------------------ AqueK405_Aque ------------------------------------------------------------ AqueK406_Aque -------------------------------------------MEGVFGV---------- RYK_Hsap ------------------------------------------------------------ lin-18_Cele ------------------------------------------------------------ drl_Dmel ------------------------------------------------------------ dnt_Dmel ------------------------------------------------------------ Drl-2_Dmel ------------------------------------------------------------ RYK_Mmus ------------------------------------------------------------ Ryk_Spur ------------------------------------------------------------ AqueK403_Aque YRGNSIIIICYAPHHLLAALLLEAQDNLTVLMKKFSLIRLTIGHYTVYDKRIRYKVMNNE AqueK404_Aque ------------------------------------------------------------ AqueK405_Aque ------------------------------------------------------------ AqueK406_Aque ------------------------------------------------------------ RYK_Hsap -----------------------------------------------------------I lin-18_Cele -----------------------------------------------------------V drl_Dmel -----------------------------------------------------------I dnt_Dmel -----------------------------------------------------------V Drl-2_Dmel -----------------------------------------------------------I RYK_Mmus -----------------------------------------------------------I Ryk_Spur -----------------------------------------------------------V AqueK403_Aque CLAEEIKLADGEEQELRTLLDYKExSGDEGDIPSSCVYSMLESLQLLEFILSVEEVSLPI AqueK404_Aque ------------------------------------------------------------ AqueK405_Aque ------------------------------------------------------------ AqueK406_Aque -----------------------------------------------------------M RYK_Hsap FHGILI-----------DEKD-PNKEKQAFVKTVKDQA---------------------- lin-18_Cele RYAIWRQVDDVLNGDVDDEEDTFCNQEAVYTKTLKNNA---------------------- drl_Dmel YRGTYN-----------DC-------QEVLVKTVAQHA---------------------- dnt_Dmel YRGTYN-----------DT-------QDVLVKTVAQHA---------------------- Drl-2_Dmel YAGKLG-----------E-------SCEALVKTVIDGA---------------------- RYK_Mmus FHGILV-----------DEKD-PNKEKQTFVKTVKDQA---------------------- Ryk_Spur HQGVLI-----------SAT--GDSEQDVFIKTVTDHS---------------------- AqueK403_Aque LQK-IR-----------DDSSSNDEKASLFLETINDDPIMISALRQDKEQHDEGETWSVD AqueK404_Aque --GYLT-----------NAEDDVEGAIPVIIKTVKD------------------------ AqueK405_Aque ------------------------------------------------------------ AqueK406_Aque YEGYLT-----------NAEDDVEGAIPVIIKTVKDNT---------------------- RYK_Hsap ----------------------------------SEIQVTMMLTESCKLRGLH-HRNL-- lin-18_Cele ----------------------------------SPIQLDRFLSDALLFYNITPHQNL-- drl_Dmel ----------------------------------SQLQVNLLLQESMMLYEAS-HPNV-- dnt_Dmel ----------------------------------SQMQVLLLLQEGMLLYGAS-HPGI-- Drl-2_Dmel ----------------------------------SLTQVACLLQDASLLIGVS-HQHI-- RYK_Mmus ----------------------------------SEVQVTMMLTESCKLRGLH-HRNL-- Ryk_Spur ----------------------------------SEEQRHLLVKESCLLQGLS-HKNI-- AqueK403_Aque WYSDSVSLTSPSPVQCNEVISNINDDHKVVELDSSSTNSTVSLLSSNKLHTVN-LRSLEI AqueK404_Aque ------------------------------------------------------------ AqueK405_Aque ------------------------------------------------------------ AqueK406_Aque ----------------------------------PDIVVKSLLEGGAATRGVI-HRHL-- RYK_Hsap --LPITHVCI--------EEGEKPMVILPYM-NWGNLKLFLRQCKLV-----EA---NNP lin-18_Cele --SQVACVASFGRFDRPETVTDFPLVCYRHQ-GFGNLKKFLTICRHG-----DK--TKGA drl_Dmel --LSVLGISI--------EDYATPFVLYAATGSVRNLKSFLQDP-------------SYA dnt_Dmel --LSVLGVSI--------EDHTTPFVLYPALNNTRNLKQFLLDP-------------ACA Drl-2_Dmel --LAPLLANT--------ELPGPPEIAYPHP-SKGNLKMYLQKSR------------ESS RYK_Mmus --LPITHVCI--------EEGEKPMVVLPYM-NWGNLKLFLRQCKLV-----EA---NNP Ryk_Spur --LPLLHVCF--------S--DPPFILEAFM-KLGNLKQFLKNGRIG-----PG---DKH AqueK403_Aque RATPLTNDCI--------QY----LCILLTN-NKTIQELVIRYH-----S-ISDRGV--- AqueK404_Aque --------------------LEQPMLLYPKS-SFGTLKTLLLKTREGGGIMLPGNNSGQC AqueK405_Aque ---------A--------SDLEQPMLLYPKS-SFGTLKTLLLKTREGGGIMLPGNNSGQC AqueK406_Aque --LPLIGAHA--------SDLEQPMLLYPKS-SFGTLKTLLLKTREGGGIMLPGNNSGQC : : RYK_Hsap QAISQQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDD-----TLQVKITDNALSRD lin-18_Cele QTLRTHQLVSLATQVSSAVAHIHKYRIVHNDIAARNCLIAEVN--GRLQVQLCDSALSRD drl_Dmel RSVTTIQTVLMGSQLAMAMEHLHNHGVIHKDIAARNCVIDD-----QLRVKLTDSALSRD dnt_Dmel RTVTTIQIVMMASQLSMALDHLHSHGVVHKDIATRNCVIDD-----QLRVKLSDSSLSRD Drl-2_Dmel TALSTRQLVEFGLHITKGLAYLHSLGIVHKDIATRNCYLDE-----ESYVKICDSALSRD RYK_Mmus QAISQQDLVHMAIQIACGMSYLARREVIHRDLAARNCVIDD-----TLQVKITDNALSRD Ryk_Spur QAISTRDLVHLAIQITHGMMYLGKKRLVHKDLATRNCVIDE-----DYNLKITDNALSRD AqueK403_Aque ------------TNICQALEH--NSTLTSLDLS-YNPLITSTSGKALSHLLLNNSSLVKL AqueK404_Aque TYISTHDLVFISEQVARGMYHLTRKGQVHKDLACRNIYIHE-----NLHVKIGDRGLSWD AqueK405_Aque TYISTHDLVFISEQVARGMYHLTRKGQVHKDLACRNIYIHE-----NLHVKIGDRGLSWD AqueK406_Aque TYISTHDLVFISEQVARGMYHLTRKGQVHKDLACRNIYIHE-----NLHVKIGDRGLSWD :: .: : *:: * : . : : : .* RYK_Hsap LFPMDYHCLGDN-------ENRPVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQTP lin-18_Cele LFPADYHCLGDN-------ENRPLKWMSPEAIANELYSSAADVWSLGVLLWELMSLGGSP drl_Dmel LFPGDYNSLGDG-------EYRPIKWLSLEALQKSHYNEGSDVWSFGVLMWEMCTLGKLP dnt_Dmel LFPSDYNCLGDS-------ENRPVKWMSLEALQHKQFSEASDSWAFGVLMWELCTSAKQP Drl-2_Dmel LFPDDYDCLGDN-------ENRPLKWLSLESLQKRVYATQGDVWALGVTYWELVTLAQMP RYK_Mmus LFPMDYHCLGDN-------ENRPVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQTP Ryk_Spur LFPSDYHCLGDN-------ENRPVKWMAVESLVHKKFSHASDVWSFGVTLWELVTLGQTP AqueK403_Aque NITEDYNTIEERGGGGDETIAYPVKWMAAEVLSDKRYSSSSDVWSFGVVLWEIMTRGKTP AqueK404_Aque FYPEDYNTIEERGGGGDETIAYPVKWMAAEVLSDKRYSSSSDVWSFGVVLWEIMTRGKTP AqueK405_Aque FYPEDYNTIEERGGGGDETIAYPVKWMAAEVLSDKRYSSSSDVWSFGVVLWEIMTRGKTP AqueK406_Aque FYPEDYNTIEERGGGGDETIAYPVKWMAAEVLSDKRYSSSSDVWSFGVVLWEIMTRGKTP . **. : : *::*:: * : . : .* *::** **: : . * RYK_Hsap YVDIDPFEMAAYLKDGYRIAQPINCPDELFAVM------------ACCWALDPEER---- lin-18_Cele HAEIDPEEVYTMILKGKRLQQPNNCPDQLYEVM------------LCCWRVLSEDR---- drl_Dmel YAEIDPYEMEHYLKDGYRLAQPFNCPDELFTIM------------AYCWASMPAER---- dnt_Dmel YAEVDPFEMEHYLKDGYRLAQPFNCPDELFTIM------------AYCWALLPAER---- Drl-2_Dmel HEEVDIFELTNYLAAGFRLEQPVNCPDEFFTVM------------NCCWHCEAKQR---- RYK_Mmus YVDIDPFEMAAYLKDGYRIAQPINCPDELFAVM------------ACCWALDPEER---- Ryk_Spur YMDLDPFEMATFLKSGYRMPQPPSCPDELLPPYTRHLHLSFLKLASQCLSAQSSNLTHQK AqueK403_Aque YEDVLPENMLNYLTTGHRLPQPKNCPDDLRDL-------------------SPSQR---- AqueK404_Aque YEDVLPENMLNYLTTGHRLPQPKNCPDDLFSLM------------GWCWALTPSDR---- AqueK405_Aque YEDVLPENMLNYLTTGHRLPQPKNCPDDLFSLM------------GWCWALTPSDR---- AqueK406_Aque YEDVLPENMLNYLTTGHRLPQPKNCPDDLFSLM------------GWCWALTPSDR---- : :: :: : * *: ** .***:: . : RYK_Hsap ------------------------------------------------------------ lin-18_Cele ------------------------------------------------------------ drl_Dmel ------------------------------------------------------------ dnt_Dmel ------------------------------------------------------------ Drl-2_Dmel ------------------------------------------------------------ RYK_Mmus ------------------------------------------------------------ Ryk_Spur VETMMDAYTRHLHLSFLKLHSQCLSAQSSNLTQQIVETMMDAYTRHLHLSFLKLASQCLS AqueK403_Aque ------------------------------------------------------------ AqueK404_Aque ------------------------------------------------------------ AqueK405_Aque ------------------------------------------------------------ AqueK406_Aque ------------------------------------------------------------ RYK_Hsap ----PKFQQLVQ------------------------------------------------ lin-18_Cele ----PSSEQVVH------------------------------------------------ drl_Dmel ----PSFSQLQ------------------------------------------------- dnt_Dmel ----PTFAQLQ------------------------------------------------- Drl-2_Dmel ----PTPSQLLS------------------------------------------------ RYK_Mmus ----PKFQQLVQ------------------------------------------------ Ryk_Spur AQSSNLTQQIVETMMDAYTRHLHLSFLKLHSQCGLSAQSSNLTQQKVETMMDAYTRHLHL AqueK403_Aque ----SDRSILFREK------------DKL-VESG-------------------------- AqueK404_Aque ----PRFSHLT------------------------------------------------- AqueK405_Aque ----PRFSHLT------------------------------------------------- AqueK406_Aque ----PRFSHLT------------------------------------------------- : RYK_Hsap ------------------------------------------------------------ lin-18_Cele ------------------------------------------------------------ drl_Dmel ------------------------------------------------------------ dnt_Dmel ------------------------------------------------------------ Drl-2_Dmel ------------------------------------------------------------ RYK_Mmus ------------------------------------------------------------ Ryk_Spur SFLKLHSQCLSAQSSNLTQQKVETMMDAYTLHLHLSFLKLHSQCLSAQSSNLTQQKVETM AqueK403_Aque ------------------------------------------------------------ AqueK404_Aque ------------------------------------------------------------ AqueK405_Aque ------------------------------------------------------------ AqueK406_Aque ------------------------------------------------------------ RYK_Hsap ------------------------------------------------------------ lin-18_Cele ------------------------------------------------------------ drl_Dmel ------------------------------------------------------------ dnt_Dmel ------------------------------------------------------------ Drl-2_Dmel ------------------------------------------------------------ RYK_Mmus ------------------------------------------------------------ Ryk_Spur MDAYTLHLHLSFLKLASQCLSAQSSNLTQQKVETMMDAYTRHLHLSFLKLHSQCLSAQSS AqueK403_Aque ------------------------IDIT---------------T-----IK-I--RKSHL AqueK404_Aque ------------------------------------------------------------ AqueK405_Aque ------------------------------------------------------------ AqueK406_Aque ------------------------------------------------------------ RYK_Hsap ----------------------------CL------------------------------ lin-18_Cele ----------------------------GL------------------------------ drl_Dmel -------I--------------------CL------------------------------ dnt_Dmel -------S--------------------CL------------------------------ Drl-2_Dmel ----------------------------YL------------------------------ RYK_Mmus ----------------------------CL------------------------------ Ryk_Spur NLTQQIVGTMMDAYTLHLHLSFLKLHSQCLSAQSSNLTQQIVGTMMDAYTRHLHLSFLKL AqueK403_Aque YVSDRLVG--------------------RV------------------------------ AqueK404_Aque -------V--------------------RL------------------------------ AqueK405_Aque -------V--------------------RL------------------------------ AqueK406_Aque -------V--------------------RL------------------------------ : RYK_Hsap -------------TEFHAALGAYV lin-18_Cele -------------RDFNIQLSQYI drl_Dmel -------------SEFHTQITRYV dnt_Dmel -------------SEFYSQITRYV Drl-2_Dmel -------------QDFHADLGMYI RYK_Mmus -------------TEFHAALGAYV Ryk_Spur ASQCGLSAQSSNLTQQRVKTMMDA AqueK403_Aque -------------ANGFINSYTCN AqueK404_Aque -------------KEFYDQLGSFI AqueK405_Aque -------------KEFYDQLGSFI AqueK406_Aque -------------KEFYDQLGSFI :