CLUSTAL W (1.83) multiple sequence alignment SRPK2_Hsap MSSRKV------------------------------------------------------ SRPK1_Hsap MERKV------------------------------------------------------- MSSK1_Hsap MSASTG------------------------------------------------------ MSSK1_Mmus MSANAG------------------------------------------------------ SKY1_Scer MGSSIN------------------------------------------------------ CG8565_Dmel MFKMKRTRV--------------------------------------------------- SRPK_Dmel MNKADVNRRV-------------------------------------------------- SRPK1_Mmus MERKV------------------------------------------------------- SRPK2_Mmus MSSRKV------------------------------------------------------ spk-1_Cele MGGPEKNSTV-------------------------------------------------- Sky1_Ddis MSDIQQ------------------------------------------------------ 13234_Tthe MNSKLM------------------------------------------------------ 22244_Tthe MKPNLA------------------------------------------------------ 3884_Tthe MRKINM------------------------------------------------------ SRPK_Spur MTDNNG------------------------------------------------------ CG11489_Dmel MLLSLAGRLHLLSRHILGTLGQDPIFMGVLQGSLLMLFLFLMHLLRLWSCGYAVERPLNP CC1G_15433_Ccin MG---------------------------------------------------------- CC1G_02719_Ccin MSKAAK------------------------------------------------------ CC1G_05630_Ccin MASPYP------------------------------------------------------ CC1G_06188_Ccin MLSVQT------------------------------------------------------ CC1G_13566_Ccin MSIVNW------------------------------------------------------ CC1G_09673_Ccin MAIQTL------------------------------------------------------ CC1G_10260_Ccin MAPKPP------------------------------------------------------ CC1G_04899_Ccin MSHGSY------------------------------------------------------ AqueK134_Aque MVFRCF------------------------------------------------------ SRPK_b_Smoe MARPDG------------------------------------------------------ SRPK_d_Smoe MASRHA------------------------------------------------------ SRPK_a_Smoe MASRHA------------------------------------------------------ SRPK_c_Smoe MARPDG------------------------------------------------------ GK042_Glam MAWAPL------------------------------------------------------ * SRPK2_Hsap -------------------------------L----AIQA-------------------- SRPK1_Hsap -------------------------------L----ALQA-------------------- MSSK1_Hsap ------------------------------------GGGD-------------------- MSSK1_Mmus ------------------------------------GSGS-------------------- SKY1_Scer ------------------------------------YPGF-------------------- CG8565_Dmel -------------------------------IRRKAAIIR-------------------- SRPK_Dmel -------------------------------L----AIQA-------------------- SRPK1_Mmus -------------------------------L----ALQA-------------------- SRPK2_Mmus -------------------------------L----AIQA-------------------- spk-1_Cele ------------------------------------PLPN-------------------- Sky1_Ddis ------------------------------------DSTS-------------------- 13234_Tthe ------------------------------------KKGK-------------------- 22244_Tthe ------------------------------------KKFA-------------------- 3884_Tthe ------------------------------------LQLK-------------------- SRPK_Spur -------------------------------L----QKLA-------------------- CG11489_Dmel TPDVAKELSCDFNFVSEQEKRAAQEAATEALL----EVEE-------------------- CC1G_15433_Ccin ------------------------------------------------------------ CC1G_02719_Ccin ------------------------------------E----------------------- CC1G_05630_Ccin ------------------------------------PISI-------------------- CC1G_06188_Ccin ------------------------------------AVAK-------------------- CC1G_13566_Ccin ------------------------------------NYV--------------------- CC1G_09673_Ccin ------------------------------------PRYLRLSFLPSRFAVLPSTRHVPS CC1G_10260_Ccin ------------------------------------CAKY-------------------- CC1G_04899_Ccin ------------------------------------SSYS-------------------- AqueK134_Aque ------------------------------------HCFV-------------------- SRPK_b_Smoe ------------------------------------AVDE-------------------- SRPK_d_Smoe ------------------------------------STSS-------------------- SRPK_a_Smoe ------------------------------------STSS-------------------- SRPK_c_Smoe ------------------------------------AVDE-------------------- GK042_Glam ------------------------------------RGTA-------------------- SRPK2_Hsap ---R----K--------------------------------------------------- SRPK1_Hsap ---R----K--------------------------------------------------- MSSK1_Hsap ---S---GG--------------------------------------------------- MSSK1_Mmus ---V----D--------------------------------------------------- SKY1_Scer ---V----T--------------------------------------------------- CG8565_Dmel ---A----S--------------------------------------------------- SRPK_Dmel ---K----K--------------------------------------------------- SRPK1_Mmus ---R----K--------------------------------------------------- SRPK2_Mmus ---R----K--------------------------------------------------- spk-1_Cele ---K----K--------------------------------------------------- Sky1_Ddis ---T----T--------------------------------------------------- 13234_Tthe ---K----V--------------------------------------------------- 22244_Tthe ---E----D--------------------------------------------------- 3884_Tthe ---N----I--------------------------------------------------- SRPK_Spur ---AATAAR----------------LSFFDRERLRKSFSIKKVKARISKSTTRMRVKIPS CG11489_Dmel ---K----K--------------------------------------------------- CC1G_15433_Ccin ------------------------------------------------------------ CC1G_02719_Ccin ------------------------------------------------------------ CC1G_05630_Ccin ------------------------------------------------------------ CC1G_06188_Ccin ---A----SLNRIPPLLSSVNVNNVA---------------------------------- CC1G_13566_Ccin ------------------------------------------------------------ CC1G_09673_Ccin RSSL----N--------------------------------------------------- CC1G_10260_Ccin ---Q----Y--------------------------------------------------- CC1G_04899_Ccin ------------------------------------------------------------ AqueK134_Aque ---R----K--------------------------------KV-ASLRKTVCC------- SRPK_b_Smoe ---E----E--------------------------------------------------- SRPK_d_Smoe ---S----S--------------------------------------------------- SRPK_a_Smoe ---S----S--------------------------------------------------- SRPK_c_Smoe ---E----E--------------------------------------------------- GK042_Glam ---Y----V--------------------------------------------------- SRPK2_Hsap ----------------------------------------------R-RPK--------- SRPK1_Hsap ----------------------------------------------K-RTKAK------- MSSK1_Hsap ----------------------------------------------S-GGSSS------- MSSK1_Mmus ----------------------------------------------C-GGSSS------- SKY1_Scer ----------------------------------------------KSAHLA-------- CG8565_Dmel ----------------------------------------------K-RAFQE------- SRPK_Dmel ----------------------------------------------K-RHKSR------- SRPK1_Mmus ----------------------------------------------K-RTKAK------- SRPK2_Mmus ----------------------------------------------R-RPK--------- spk-1_Cele ----------------------------------------------R-KKKTN------- Sky1_Ddis ----------------------------------------------L-G---GTSLGG-- 13234_Tthe ----------------------------------------------G-PPPGL------- 22244_Tthe ----------------------------------------------E-ALVND------- 3884_Tthe ----------------------------------------------E-QQIKETQIGDDP SRPK_Spur KLASFNPDLDIRSKLSQLALKLRGGTGDGIDGCYAHSLGSDSDSIVD-SMSGS------- CG11489_Dmel ----------------------------------------------R-RKRFT------- CC1G_15433_Ccin ------------------------------------------------------------ CC1G_02719_Ccin ------------------------------------------------------------ CC1G_05630_Ccin ------------------------------------------------------------ CC1G_06188_Ccin ----------------------------------------------A-KPSTS------- CC1G_13566_Ccin ------------------------------------------------------------ CC1G_09673_Ccin ----------------------------------------------R-RNLTA------- CC1G_10260_Ccin ------------------------------------------------------------ CC1G_04899_Ccin ------------------------------------------------------------ AqueK134_Aque ----------------------------------------------L-LAIAK------- SRPK_b_Smoe ----------------------------------------------E-G-GGA------- SRPK_d_Smoe ----------------------------------------------S-RSIGD------- SRPK_a_Smoe ----------------------------------------------S-RSIGD------- SRPK_c_Smoe ------------------------------------------------G-GGA------- GK042_Glam ----------------------------------------------S-QPEEA------- SRPK2_Hsap ------------------------------------------------------------ SRPK1_Hsap ------------------------------------------------------------ MSSK1_Hsap ------------------------------------------------------------ MSSK1_Mmus ------------------------------------------------------------ SKY1_Scer ------------------------------------------------------------ CG8565_Dmel ------------------------------------------------------------ SRPK_Dmel ------------------------------------------------------------ SRPK1_Mmus ------------------------------------------------------------ SRPK2_Mmus ------------------------------------------------------------ spk-1_Cele ------------------------------------------------------------ Sky1_Ddis ------------------------------------------------------------ 13234_Tthe ------------------------------------------------------------ 22244_Tthe ------------------------------------------------------------ 3884_Tthe QIEIQIGITQKEREGDGNSHAFSLYPFKDFSSLSFLYQSIQIKSHGLPIFSSKQLIFIKI SRPK_Spur ------------------------------------------------------------ CG11489_Dmel ------------------------------------------------------------ CC1G_15433_Ccin ------------------------------------------------------------ CC1G_02719_Ccin ------------------------------------------------------------ CC1G_05630_Ccin ------------------------------------------------------------ CC1G_06188_Ccin ------------------------------------------------------------ CC1G_13566_Ccin ------------------------------------------------------------ CC1G_09673_Ccin ------------------------------------------------------------ CC1G_10260_Ccin ------------------------------------------------------------ CC1G_04899_Ccin ------------------------------------------------------------ AqueK134_Aque ------------------------------------------------------------ SRPK_b_Smoe ------------------------------------------------------------ SRPK_d_Smoe ------------------------------------------------------------ SRPK_a_Smoe ------------------------------------------------------------ SRPK_c_Smoe ------------------------------------------------------------ GK042_Glam ------------------------------------------------------------ SRPK2_Hsap ---------------------------------------------------R--E----- SRPK1_Hsap ---------------------------------------------------K--D----- MSSK1_Hsap ---------------------------------------------------S--S----- MSSK1_Mmus ---------------------------------------------------S--S----- SKY1_Scer -----------------------------------DTSTDASISCEEATSSQ--E-AKKN CG8565_Dmel ---------------------------------------------------K--I----- SRPK_Dmel ---------------------------------------------------K--R----- SRPK1_Mmus ---------------------------------------------------K--D----- SRPK2_Mmus ---------------------------------------------------R--E----- spk-1_Cele ---------------------------------------------------K--K----- Sky1_Ddis -----TSLGGTSLGGTSLGGTSLGGTSLGGTSLGGSTTTS-TTTPK-STNSK--N----- 13234_Tthe ---------------------------------------------------Q--Q----- 22244_Tthe ------------------------------------------------------------ 3884_Tthe DLLQSTGTSF-----------------LGQVNMNHSSSTATTVSTN-GQ--Y--S----- SRPK_Spur ---------------------------------------------------P--S----- CG11489_Dmel ---------------------------------------------------K--KRNCVS CC1G_15433_Ccin ------------------------------------------------------------ CC1G_02719_Ccin ------------------------------------------------------------ CC1G_05630_Ccin ------------------------------------------------------------ CC1G_06188_Ccin ---------------------------------------------------TLSN----- CC1G_13566_Ccin ------------------------------------------------------------ CC1G_09673_Ccin ---------------------------------------------------S--S----- CC1G_10260_Ccin ------------------------------------------------------------ CC1G_04899_Ccin ------------------------------------------------------------ AqueK134_Aque ---------------------------------------------------K--K----- SRPK_b_Smoe ------------------------------------------------------------ SRPK_d_Smoe ---------------------------------------------------E--I----- SRPK_a_Smoe ---------------------------------------------------E--I----- SRPK_c_Smoe ------------------------------------------------------------ GK042_Glam ---------------------------------------------------A-------- SRPK2_Hsap ------------------------------------------------------------ SRPK1_Hsap ------------------------------------------------------------ MSSK1_Hsap ------------------------------------------------------------ MSSK1_Mmus ------------------------------------------------------------ SKY1_Scer FFQRDYNMMKKAP----------------------------------------------- CG8565_Dmel ------------------------------------------------------------ SRPK_Dmel ------------------------------------------------------------ SRPK1_Mmus ------------------------------------------------------------ SRPK2_Mmus ------------------------------------------------------------ spk-1_Cele ------------------------------------------------------------ Sky1_Ddis ------------------------------------------------------------ 13234_Tthe ------------------------------------------------------------ 22244_Tthe ------------------------------------------------------------ 3884_Tthe KKNLNGNSNNLAPSNGTYQNQNINHKGATEKENIKYADGEPVKTNFQKPQFYEDEVWIAK SRPK_Spur ------------------------------------------------------------ CG11489_Dmel AGPILIAL---------------------------------------------------- CC1G_15433_Ccin ------------------------------------------------------------ CC1G_02719_Ccin ------------------------------------------------------------ CC1G_05630_Ccin ------------------------------------------------------------ CC1G_06188_Ccin ------------------------------------------------------------ CC1G_13566_Ccin ------------------------------------------------------------ CC1G_09673_Ccin ------------------------------------------------------------ CC1G_10260_Ccin ------------------------------------------------------------ CC1G_04899_Ccin ------------------------------------------------------------ AqueK134_Aque ------------------------------------------------------------ SRPK_b_Smoe ------------------------------------------------------------ SRPK_d_Smoe ------------------------------------------------------------ SRPK_a_Smoe ------------------------------------------------------------ SRPK_c_Smoe ------------------------------------------------------------ GK042_Glam ------------------------------------------------------------ SRPK2_Hsap ----------------------------K----------------------H-------- SRPK1_Hsap ----------------------------K----------------------A-------- MSSK1_Hsap ----------------------------Q----------------------A-------- MSSK1_Mmus ----------------------------Q----------------------T-------- SKY1_Scer ----------------------------APTKSKLSLALQTSKSSSSANGTVQE-DT--- CG8565_Dmel ----------------------------R----------------------KQM--ESCG SRPK_Dmel ----------------------------G----------------------K-------- SRPK1_Mmus ----------------------------K----------------------A-------- SRPK2_Mmus ----------------------------K----------------------H-------- spk-1_Cele ----------------------------K----------------------P-------- Sky1_Ddis ----------------------------K----------------------KKK------ 13234_Tthe ----------------------------K----------------------MQQ------ 22244_Tthe ----------------------------K----------------------PHQ------ 3884_Tthe QQQQMALLQQQQQLNYQKNMDFQVAHQQE----------------------PHQ------ SRPK_Spur ----------------------------Q----------------------S-------- CG11489_Dmel ----------------------------R----------------------H----Q--- CC1G_15433_Ccin ------------------------------------------------------------ CC1G_02719_Ccin ------------------------------------------------------------ CC1G_05630_Ccin ------------------------------------------------------------ CC1G_06188_Ccin ----------------------------R----------------------EALAN---- CC1G_13566_Ccin ------------------------------------------------------------ CC1G_09673_Ccin ----------------------------R----------------------LQE------ CC1G_10260_Ccin ------------------------------------------------------------ CC1G_04899_Ccin ------------------------------------------------------------ AqueK134_Aque ----------------------------K------------------------------- SRPK_b_Smoe ----------------------------------------------------RS------ SRPK_d_Smoe ----------------------------Q----------------------AKH------ SRPK_a_Smoe ----------------------------Q----------------------AKH------ SRPK_c_Smoe ----------------------------------------------------RS------ GK042_Glam ------------------------------------------------------LD---- SRPK2_Hsap -------------------------------------PK---------------KP---- SRPK1_Hsap -------------------------------------QR---------------KS---- MSSK1_Hsap -------------------------------------SC---------------GP---- MSSK1_Mmus -------------------------------------SC---------------GP---- SKY1_Scer -------------------------------------SS---------------KTEDFS CG8565_Dmel VTQMGNASTQQSNVPMDVDADMGRKMSEDGMTDTSNTVK---------------QP---- SRPK_Dmel -------------------------------------QN---------------GT---- SRPK1_Mmus -------------------------------------QR---------------KP---- SRPK2_Mmus -------------------------------------PK---------------KP---- spk-1_Cele -------------------------------------T---------------------- Sky1_Ddis -------------------------------------QT---------------SSN--- 13234_Tthe -------------------------------------QN---------------KQ---- 22244_Tthe -------------------------------------QN---------------HQ---- 3884_Tthe -------------------------------------QYQYYEDEFQKVAGNNHNI---- SRPK_Spur -------------------------------------RQ---------------GR---- CG11489_Dmel -------------------------------------SK---------------RP---- CC1G_15433_Ccin ------------------------------------------------------------ CC1G_02719_Ccin ------------------------------------------------------------ CC1G_05630_Ccin ------------------------------------------------------------ CC1G_06188_Ccin -------------------------------------AT---------------TK---- CC1G_13566_Ccin ------------------------------------------------------------ CC1G_09673_Ccin --------------------------------------H---------------GD---- CC1G_10260_Ccin ------------------------------------------------------------ CC1G_04899_Ccin ------------------------------------------------------------ AqueK134_Aque -------------------------------------PK---------------RP---- SRPK_b_Smoe -------------------------------------AA---------------AM---- SRPK_d_Smoe -------------------------------------QG---------------GQ---- SRPK_a_Smoe -------------------------------------QG---------------GQ---- SRPK_c_Smoe -------------------------------------AA---------------AM---- GK042_Glam -------------------------------------AL---------------HY---- SRPK2_Hsap --------E---PQQ--------------------------------------------- SRPK1_Hsap --------E---TQH--------------------------------------------- MSSK1_Hsap --------E---SS---------------------------------------------- MSSK1_Mmus --------E---SS---------------------------------------------- SKY1_Scer TKSIKKKPDSGVESH--------------------------------------------- CG8565_Dmel --------SCSKDQKQ-------------------------------------------- SRPK_Dmel --------N---PQE--------------------------------------------- SRPK1_Mmus --------E---TQH--------------------------------------------- SRPK2_Mmus --------E---PQQ--------------------------------------------- spk-1_Cele ------------------------------------------------------------ Sky1_Ddis ------------NNN--------------------------------------------- 13234_Tthe ------------EE---------------------------------------------- 22244_Tthe ------------EQH--------------------------------------------- 3884_Tthe ------------ENQ--------------------------------------------- SRPK_Spur --------Q---DSDFEFVYIRQDKSKRKWQIVQIEVDSIAYVLIIAGSVVINDWALSNW CG11489_Dmel --------K---HHR--------------------------------------------- CC1G_15433_Ccin ------------------------------------------------------------ CC1G_02719_Ccin ------------------------------------------------------------ CC1G_05630_Ccin ------------------------------------------------------------ CC1G_06188_Ccin --------R---RSH--------------------------------------------- CC1G_13566_Ccin ------------------------------------------------------------ CC1G_09673_Ccin --------T---TQR--------------------------------------------- CC1G_10260_Ccin ------------------------------------------------------------ CC1G_04899_Ccin ------------------------------------------------------------ AqueK134_Aque --------N---GGA--------------------------------------------- SRPK_b_Smoe ------------EE---------------------------------------------- SRPK_d_Smoe ------------DEE--------------------------------------------- SRPK_a_Smoe ------------DEE--------------------------------------------- SRPK_c_Smoe ------------EE---------------------------------------------- GK042_Glam --------N---AKH--------------------------------------------- SRPK2_Hsap -KA--P---LVPP-PP--------PPP--------------------------------- SRPK1_Hsap -RG--S------------------------------------------------------ MSSK1_Hsap --G--S------------------------------------------------------ MSSK1_Mmus --G--S------------------------------------------------------ SKY1_Scer -VS--------IQSDS-------------------------------------------- CG8565_Dmel -LS--R-----KQ-KPS------------------------------------------- SRPK_Dmel -QS--N-SSQNQN-PK--------PSS--------------------------------- SRPK1_Mmus -RG--S------------------------------------------------------ SRPK2_Mmus -KA--P---LVPP-PP--------P----------------------------------- spk-1_Cele ------------A-PN--------TPT--------------------------------- Sky1_Ddis -NN--NNN---NNNNNE------------------------------------------- 13234_Tthe ------------------------------------------------------------ 22244_Tthe -EN--------PQKPPP--------IQ--------------------------------- 3884_Tthe -KA--------PVQEPP------------------------------------------- SRPK_Spur DKA--V---KISV-PP--------PPKWRNYSWIFLNWFGMKLERLSRAVDRLFERLRIA CG11489_Dmel -HAALP---FEPV-TPGEIILDTYLPP--------------------------------- CC1G_15433_Ccin ------------------------------------------------------------ CC1G_02719_Ccin ------------------------------------------------------------ CC1G_05630_Ccin ------------------------------------------------------------ CC1G_06188_Ccin -SM--A-----LA-VNS------------------------------------------- CC1G_13566_Ccin ------------------------------------------------------------ CC1G_09673_Ccin -RG--N------------------------------------------------------ CC1G_10260_Ccin ------------------------------------------------------------ CC1G_04899_Ccin ------------------------------------------------------------ AqueK134_Aque -K---------------------------------------------------------- SRPK_b_Smoe ----------------E------------------------------------------- SRPK_d_Smoe ----------------E------------------------------------------- SRPK_a_Smoe ----------------E------------------------------------------- SRPK_c_Smoe ----------------E------------------------------------------- GK042_Glam -TV---------L-EHA------------------------------------------- SRPK2_Hsap ---------------P--------------------------PP----P----------- SRPK1_Hsap ------------------------------------------------------------ MSSK1_Hsap ------------------------------------------------------------ MSSK1_Mmus ------------------------------------------------------------ SKY1_Scer ------------------------------------------------------------ CG8565_Dmel ---------------PSYNHQEQIEQRAKRPKICKKRCKQKRRM----P----------- SRPK_Dmel ---------------N--------------------------PI----P--EPNRSSENL SRPK1_Mmus ------------------------------------------------------------ SRPK2_Mmus ---------------P--------------------------PP----P----------- spk-1_Cele ---------------S--------------------------P----------QA---GE Sky1_Ddis ------------------------------------------------------------ 13234_Tthe ------------------------------------------------------------ 22244_Tthe ---------------F--------------------------ENNDFLG----------- 3884_Tthe ------------------------------------------------------------ SRPK_Spur VLKKFYPAINSAHSNK--------------------------PP----P-KVSVDS---- CG11489_Dmel ---------------R--------------------------EL----PLTIRL------ CC1G_15433_Ccin ------------------------------------------------------------ CC1G_02719_Ccin ------------------------------------------------------------ CC1G_05630_Ccin ------------------------------------------------------------ CC1G_06188_Ccin ------------------------------------------------------------ CC1G_13566_Ccin ------------------------------------------------------------ CC1G_09673_Ccin ------------------------------------------------------------ CC1G_10260_Ccin ------------------------------------------------------------ CC1G_04899_Ccin ------------------------------------------------------------ AqueK134_Aque ------------------------------------------------------------ SRPK_b_Smoe ------------------------------------------------------------ SRPK_d_Smoe ------------------------------------------------------------ SRPK_a_Smoe ------------------------------------------------------------ SRPK_c_Smoe ------------------------------------------------------------ GK042_Glam ------------------------------------------------------------ SRPK2_Hsap ------------------------------------------------------------ SRPK1_Hsap ------------------------------------------------------------ MSSK1_Hsap ------------------------------------------------------------ MSSK1_Mmus ------------------------------------------------------------ SKY1_Scer ------------------------------------------------------------ CG8565_Dmel ------------------------------------------------------------ SRPK_Dmel QAPDNANNSHLNAPSSAAFSKATA-----------TATASTSSGGSAGTPDQ-------- SRPK1_Mmus ------------------------------------------------------------ SRPK2_Mmus ------------------------------------------------------------ spk-1_Cele KNANLKNGTVTTNGSNHVERLAGRAVHSLSAIDYSGITNDVEAGGSF-SLTDVFPTVIFM Sky1_Ddis ------------------------------------------------------------ 13234_Tthe ------------------------------------------------------------ 22244_Tthe ------------------------------------------------------------ 3884_Tthe ------------------------------------------------------------ SRPK_Spur ------------------------------------------------------------ CG11489_Dmel ------------------------------------------------------------ CC1G_15433_Ccin ------------------------------------------------------------ CC1G_02719_Ccin ------------------------------------------------------------ CC1G_05630_Ccin ------------------------------------------------------------ CC1G_06188_Ccin ------------------------------------------------------------ CC1G_13566_Ccin ------------------------------------------------------------ CC1G_09673_Ccin ------------------------------------------------------------ CC1G_10260_Ccin ------------------------------------------------------------ CC1G_04899_Ccin ------------------------------------------------------------ AqueK134_Aque ------------------------------------------------------------ SRPK_b_Smoe ------------------------------------------------------------ SRPK_d_Smoe ------------------------------------------------------------ SRPK_a_Smoe ------------------------------------------------------------ SRPK_c_Smoe ------------------------------------------------------------ GK042_Glam ------------------------------------------------------------ SRPK2_Hsap ------------------------------------------------------------ SRPK1_Hsap ------------------------------------------------------------ MSSK1_Hsap ------------------------------------------------------------ MSSK1_Mmus ------------------------------------------------------------ SKY1_Scer ------------------------------------------------------------ CG8565_Dmel ------------------------------------------------------------ SRPK_Dmel -------------------------YQPPKKT---------------------------- SRPK1_Mmus ------------------------------------------------------------ SRPK2_Mmus ------------------------------------------------------------ spk-1_Cele FVVLFCRWLNGFSQHRERLYKFEDEA-----VQRRRRFRVHSEESEELNDHESYSETDIC Sky1_Ddis ------------------------------------------------------------ 13234_Tthe ------------------------------------------------------------ 22244_Tthe ------------------------------------------------------------ 3884_Tthe ------------------------------------------------------------ SRPK_Spur ------------------------------------------------------------ CG11489_Dmel ------------------------------------------------------------ CC1G_15433_Ccin ------------------------------------------------------------ CC1G_02719_Ccin ------------------------------------------------------------ CC1G_05630_Ccin ------------------------------------------------------------ CC1G_06188_Ccin ------------------------------------------------------------ CC1G_13566_Ccin ------------------------------------------------------------ CC1G_09673_Ccin ------------------------------------------------------------ CC1G_10260_Ccin ------------------------------------------------------------ CC1G_04899_Ccin ------------------------------------------------------------ AqueK134_Aque ------------------------------------------------------------ SRPK_b_Smoe ------------------------------------------------------------ SRPK_d_Smoe ------------------------------------------------------------ SRPK_a_Smoe ------------------------------------------------------------ SRPK_c_Smoe ------------------------------------------------------------ GK042_Glam ------------------------------------------------------------ SRPK2_Hsap -------------------------------------P---------------------- SRPK1_Hsap -------------------------------------A---------------------- MSSK1_Hsap -------------------------------------E---------------------- MSSK1_Mmus -------------------------------------E---------------------- SKY1_Scer -------------------------------------G---------------------- CG8565_Dmel -------------------------------------SSLSDDGIAGRKPAKINKYSELS SRPK_Dmel ----------------------------QAKAKP-NTQ---------------------- SRPK1_Mmus -------------------------------------A---------------------- SRPK2_Mmus -------------------------------------P---------------------- spk-1_Cele TQLLASSADVTCHINVDLVNQNRFYFFVKQRNKKENST---------------------- Sky1_Ddis ------------------------------------------------------------ 13234_Tthe ------------------------------------------------------------ 22244_Tthe -------------------------------------V---------------------- 3884_Tthe ------------------------------------------------------------ SRPK_Spur -------------------------------------E---------------------- CG11489_Dmel -------------------------------------P---------------------- CC1G_15433_Ccin ------------------------------------------------------------ CC1G_02719_Ccin ------------------------------------------------------------ CC1G_05630_Ccin ------------------------------------------------------------ CC1G_06188_Ccin -------------------------------------P---------------------- CC1G_13566_Ccin ------------------------------------------------------------ CC1G_09673_Ccin -------------------------------------G---------------------- CC1G_10260_Ccin ------------------------------------------------------------ CC1G_04899_Ccin ------------------------------------------------------------ AqueK134_Aque -------------------------------------K---------------------- SRPK_b_Smoe ------------------------------------------------------------ SRPK_d_Smoe ------------------------------------------------------------ SRPK_a_Smoe ------------------------------------------------------------ SRPK_c_Smoe ------------------------------------------------------------ GK042_Glam -------------------------------------P---------------------- SRPK2_Hsap ------------------------------------------------------------ SRPK1_Hsap ------------------------------------------------------------ MSSK1_Hsap ------------------------------------------------------------ MSSK1_Mmus ------------------------------------------------------------ SKY1_Scer -------P-Q-------------------------------------------------- CG8565_Dmel YGSESSMPFE-------------------------------------------------- SRPK_Dmel -------K-EHQQ----------------------------------------------- SRPK1_Mmus ------------------------------------------------------------ SRPK2_Mmus ------------------------------------------------------------ spk-1_Cele -------N-EEEEISSQEINTSTQNEETEVNLVFASAEDNGGVASNFDISDALMVTSNIS Sky1_Ddis ---------N-------------------------------------------------- 13234_Tthe ------------------------------------------------------------ 22244_Tthe -------P-E-------------------------------------------------- 3884_Tthe ---------Q-------------------------------------------------- SRPK_Spur -------D-E-------------------------------------------------- CG11489_Dmel ---QLAEP-V-------------------------------------------------- CC1G_15433_Ccin ------------------------------------------------------------ CC1G_02719_Ccin ------------------------------------------------------------ CC1G_05630_Ccin ------------------------------------------------------------ CC1G_06188_Ccin ---------T-------------------------------------------------- CC1G_13566_Ccin ------------------------------------------------------------ CC1G_09673_Ccin ------------------------------------------------------------ CC1G_10260_Ccin ------------------------------------------------------------ CC1G_04899_Ccin ------------------------------------------------------------ AqueK134_Aque ------------------------------------------------------------ SRPK_b_Smoe ---------E-------------------------------------------------- SRPK_d_Smoe ---------E-------------------------------------------------- SRPK_a_Smoe ---------E-------------------------------------------------- SRPK_c_Smoe ---------E-------------------------------------------------- GK042_Glam ------------------------------------------------------------ SRPK2_Hsap ------------------------------------------------------------ SRPK1_Hsap ------------------------------------------------------------ MSSK1_Hsap ------------------------------------------------------------ MSSK1_Mmus ------------------------------------------------------------ SKY1_Scer ------------------------------------------------------------ CG8565_Dmel ------------------------------------------------------------ SRPK_Dmel ------------------------------------------------------------ SRPK1_Mmus ------------------------------------------------------------ SRPK2_Mmus ------------------------------------------------------------ spk-1_Cele EVSKLPETLCEEGETVQQKSVVNENDHSNEDDEQSLQSQDGSRCSDEDMNSCVSASDEED Sky1_Ddis ------------------------------------------------------------ 13234_Tthe ------------------------------------------------------------ 22244_Tthe ------------------------------------------------------------ 3884_Tthe ------------------------------------------------------------ SRPK_Spur ------------------------------------------------------------ CG11489_Dmel ------------------------------------------------------------ CC1G_15433_Ccin ------------------------------------------------------------ CC1G_02719_Ccin ------------------------------------------------------------ CC1G_05630_Ccin ------------------------------------------------------------ CC1G_06188_Ccin ------------------------------------------------------------ CC1G_13566_Ccin ------------------------------------------------------------ CC1G_09673_Ccin ------------------------------------------------------------ CC1G_10260_Ccin ------------------------------------------------------------ CC1G_04899_Ccin ------------------------------------------------------------ AqueK134_Aque ------------------------------------------------------------ SRPK_b_Smoe ------------------------------------------------------------ SRPK_d_Smoe ------------------------------------------------------------ SRPK_a_Smoe ------------------------------------------------------------ SRPK_c_Smoe ------------------------------------------------------------ GK042_Glam ------------------------------------------------------------ SRPK2_Hsap ------------------------------------------------------------ SRPK1_Hsap ------------------------------------------------------------ MSSK1_Hsap ------------------------------------------------------------ MSSK1_Mmus ------------------------------------------------------------ SKY1_Scer ------------------------------------------------------------ CG8565_Dmel ------------------------------------------------------------ SRPK_Dmel ------------------------------------------------------------ SRPK1_Mmus ------------------------------------------------------------ SRPK2_Mmus ------------------------------------------------------------ spk-1_Cele VESQDDSFHVNDATEESIDSVSSIESQEAEESATEDLASCHSNDDKNEKDVLVDEDTSKY Sky1_Ddis ------------------------------------------------------------ 13234_Tthe ------------------------------------------------------------ 22244_Tthe ------------------------------------------------------------ 3884_Tthe ------------------------------------------------------------ SRPK_Spur -------------------------D---------------------------------- CG11489_Dmel -------------------------K---------------------------------- CC1G_15433_Ccin ------------------------------------------------------------ CC1G_02719_Ccin ------------------------------------------------------------ CC1G_05630_Ccin ------------------------------------------------------------ CC1G_06188_Ccin ------------------------------------------------------------ CC1G_13566_Ccin ------------------------------------------------------------ CC1G_09673_Ccin ------------------------------------------------------------ CC1G_10260_Ccin ------------------------------------------------------------ CC1G_04899_Ccin ------------------------------------------------------------ AqueK134_Aque ------------------------------------------------------------ SRPK_b_Smoe ------------------------------------------------------------ SRPK_d_Smoe ------------------------------------------------------------ SRPK_a_Smoe ------------------------------------------------------------ SRPK_c_Smoe ------------------------------------------------------------ GK042_Glam ------------------------------------------------------------ SRPK2_Hsap ------------------------------------------------------------ SRPK1_Hsap ------------------------------------------------------------ MSSK1_Hsap ------------------------------------------------------------ MSSK1_Mmus ------------------------------------------------------------ SKY1_Scer ------------------------------------------------------------ CG8565_Dmel ------------------------------------------------------------ SRPK_Dmel ------------------------------------------------------------ SRPK1_Mmus ------------------------------------------------------------ SRPK2_Mmus ------------------------------------------------------------ spk-1_Cele DNLPVEMRSAKEGEESEGTIDSSVSSSTSSSSTGDDGDDSATSYDSEDIEIQMFEYDLGT Sky1_Ddis ------------------------------------------------------------ 13234_Tthe ------------------------------------------------------------ 22244_Tthe ------------------------------------------------------------ 3884_Tthe ------------------------------------------------------------ SRPK_Spur ------------------------------------------------------------ CG11489_Dmel ------------------------------------------------------------ CC1G_15433_Ccin ------------------------------------------------------------ CC1G_02719_Ccin ------------------------------------------------------------ CC1G_05630_Ccin ------------------------------------------------------------ CC1G_06188_Ccin ------------------------------------------------------------ CC1G_13566_Ccin ------------------------------------------------------------ CC1G_09673_Ccin ------------------------------------------------------------ CC1G_10260_Ccin ------------------------------------------------------------ CC1G_04899_Ccin ------------------------------------------------------------ AqueK134_Aque ------------------------------------------------------------ SRPK_b_Smoe ------------------------------------------------------------ SRPK_d_Smoe ------------------------------------------------------------ SRPK_a_Smoe ------------------------------------------------------------ SRPK_c_Smoe ------------------------------------------------------------ GK042_Glam ------------------------------------------------------------ SRPK2_Hsap -------PL-----------------P--------------------------------- SRPK1_Hsap -------PH-----------------S--------------------------------- MSSK1_Hsap -------LA-----------------L--------------------------------- MSSK1_Mmus -------LT-----------------P--------------------------------- SKY1_Scer --------SD----------------S--------------------------------- CG8565_Dmel -------MKQ----------------Q--------------------------------- SRPK_Dmel -------QP-----------------P--------------------------------- SRPK1_Mmus -------PH-----------------S--------------------------------- SRPK2_Mmus -------PL-----------------P--------------------------------- spk-1_Cele ACASASISI-----------------PRPSIIPRNNKKTEVNANEERLDDLSVSPGRSDS Sky1_Ddis -------NR--------------------------------------------------- 13234_Tthe -------YDE----------------S--------------------------------- 22244_Tthe -------MEG----------------L--------------------------------- 3884_Tthe -------QK--------------------------------------------------- SRPK_Spur -------DEE----------------Q--------------------------------- CG11489_Dmel -------EEEVEYIELKSEPRGTLSTT--------------------------------- CC1G_15433_Ccin ------------------------------------------------------------ CC1G_02719_Ccin ------------------------------------------------------------ CC1G_05630_Ccin ------------------------------------------------------------ CC1G_06188_Ccin -------EF-----------------F--------------------------------- CC1G_13566_Ccin --------------------------P--------------------------------- CC1G_09673_Ccin -------LSM----------------P--------------------------------- CC1G_10260_Ccin -------VVT----------------P--------------------------------- CC1G_04899_Ccin ------------------------------------------------------------ AqueK134_Aque -------PTS----------------S--------------------------------- SRPK_b_Smoe -------EE--------------------------------------------------- SRPK_d_Smoe -------EEG----------------E--------------------------------- SRPK_a_Smoe -------EEG----------------E--------------------------------- SRPK_c_Smoe -------EE--------------------------------------------------- GK042_Glam --------------------------L--------------------------------- SRPK2_Hsap ---------DP-TPPEPEEEILGSDDEEQEDPADYCK-GGYHPVKIGDLF---------- SRPK1_Hsap ---------ES-DLPEQEEEILGSDDDEQEDPNDYCK-GGYHLVKIGDLF---------- MSSK1_Hsap ---------AT-PVPQMLQGLLGSDDEEQEDPKDYCK-GGYHPVKIGDVF---------- MSSK1_Mmus ---------AT-PAPRLLQGLLGSDDEEQEDPKDYCK-GGYYPVKIGDLF---------- SKY1_Scer ------------D-LDSDSSISSCDERNEESLKDYRP-GGYHPAFKGEPYK--------- CG8565_Dmel ---------SN-DNQNNNDNAEGSGFDRQESANEYVI-GGYHPVAIGDVF---------- SRPK_Dmel ---------RS-SSNESYESETFSDNEDQELMEDYCK-GGYHPVNIGDLF---------- SRPK1_Mmus ---------ES-DIPEQEEEILGSDDDEQEDPNDYCK-GGYHLVKIGDLF---------- SRPK2_Mmus ---------DP-APPEPEEEILGSDDEEQEDPADYCK-GGYHPVKIGDLF---------- spk-1_Cele PGGGGGGHSDSFQDPMDPGEQLGSDDEEQEDPRDYKR-GGYHPVNIGDVF---------- Sky1_Ddis ---------DN-DAGSSNKSFMPLNNNEDEGTKDYKQ-GGYHPVRRNDVY---------- 13234_Tthe ------------SSESD-YDPEFEHPDDAEDFEDYRP-DGYHPTILGEKFK--------- 22244_Tthe ---------TT-KSDKQVYNIDEENDSEDEGIEDYKI-GGYHPVHIGEVI---------- 3884_Tthe ---------EP-TLEDIMNQVDMEHDSEDEGIQDYKI-GGYHPVHIGEVV---------- SRPK_Spur ---------EE-GQEGEEQGAYGSDEDEQEDPQDYCK-GGYHPVKIFDLF---------- CG11489_Dmel ---------DE-IYPDSSDSSLYVSDEEQEDASQYCR-GGYHPVVIGDIF---------- CC1G_15433_Ccin ------------------------------------------------------------ CC1G_02719_Ccin ------------------D-GVFVFKEDPNVFSPPGY-FGYAPIKLGQRFTNLDRISPPT CC1G_05630_Ccin ------------GGPGGDYRYRPSNLDDVENVENYVE-GVYHPVSIGDTLA--------- CC1G_06188_Ccin ---------TS-TIPSVTQRVKPIGFDEEPCTLGLQDGYSYARVEIGDRFGA-------- CC1G_13566_Ccin ---------KP-PD---PEPVSDTFPEEPLDLPVSFG-GGYYSGQLGTTVS--------- CC1G_09673_Ccin ---------RH-SSKDSGRPLS-PGPSSEV-----DS-LRYFPAQLNTVLRG-------- CC1G_10260_Ccin ------------AGP-KIVPVDEPSCKDEESPADYNA-GGYLPVKVNDTFK--------- CC1G_04899_Ccin ---------------------ASIMTEDEEDWEDYVK-GGYHPVKIGDEFS--------- AqueK134_Aque ---------LK-SPEAQSEDEYDTTDDEQEDAADYCK-GGYHLVEIGEVY---------- SRPK_b_Smoe ---------SL-LL-DREEEEVVFKNDDEESSEDYRP-GGYHPVCVGDLYK--------- SRPK_d_Smoe ---------SS-EEE--EEEEEEEASSEEEGADEYKR-GGYHPVCIGDSFS--------- SRPK_a_Smoe ---------SS-EEEEEEEEEEEEASSEEEGVDEYKR-GGYHPVCIGDSFS--------- SRPK_c_Smoe ---------SL-LL-NREEEEVVFKNDDEESSEDYRP-GGYHPVCVGDLYK--------- GK042_Glam ---------AS-VIP--TK--TVIHHTIDEGTIAYQE-GGFCRITPGEILH--------- SRPK2_Hsap ------NGRYHVIRKLGWGHFSTVWLCWDMQG---------------------------- SRPK1_Hsap ------NGRYHVIRKLGWGHFSTVWLSWDIQG---------------------------- MSSK1_Hsap ------NGRYHVVRKLGWGHFSTVWLCWDIQR---------------------------- MSSK1_Mmus ------NGRYHVVRKLGWGHFSTVWLCWDIQR---------------------------- SKY1_Scer ------DARYILVRKLGWGHFSTVWLAKDMVN---------------------------- CG8565_Dmel ------VNRYHVFKKLGWGHFSTVWLCYDTQM---------------------------- SRPK_Dmel ------HDRYHVIRKLGWGHFSTVWLCWDLQA---------------------------- SRPK1_Mmus ------NGRYHVIRKLGWGHFSTVWLSWDIQG---------------------------- SRPK2_Mmus ------NGRYHVIRKLGWGHFSTVWLCWDMQG---------------------------- spk-1_Cele ------NARYHVIRKLGWGHFSTVWLAWDTQD---------------------------- Sky1_Ddis ------GNRYQVVDKLGWGHFSTVWLCNDKDTPITTSSSSSSTTTTTTSSSSNGNGNGNG 13234_Tthe ------DGRYTIVQKLGWGHFSTVWLAYDKET---------------------------- 22244_Tthe ------NKRYVIIQKLGWGHFSTVWLSKDFKY---------------------------- 3884_Tthe ------NKRYVVIQKIGWGHFSTVWLAKDFKY---------------------------- SRPK_Spur ------NGKYHVVRKLGWGHFSTVWLAWDLTG---------------------------- CG11489_Dmel ------DNRFRVVRKLGWGHFSTVWLCRDLKD---------------------------- CC1G_15433_Ccin ----------VIVGKLGYGTWGTAWLRRDLVN---------------------------- CC1G_02719_Ccin FALTNTTESYEVVRKLGWGQEANVWLARRYTKDNPK------------------------ CC1G_05630_Ccin ------NGRYKLIHKLGFGGSSTVWLARDQQPDSTT------------------------ CC1G_06188_Ccin ------QDRYEVVRKLGWGLYATTWLIKDRRDD--------------------------- CC1G_13566_Ccin ------SNRYLIVRKLGYGPRSSTWLVKESGR---------------------------- CC1G_09673_Ccin ------NPKITVIRKLGSGPRSSTWLVKHIES---------------------------- CC1G_10260_Ccin ------QGRYRVVRKLGWGHFSTVWLVKDSQSG--------------------------- CC1G_04899_Ccin ------DGRYVVVRKLGWGHFSTVWLARDTKMN--------------------------- AqueK134_Aque ------NGRYQIIRKLGWGHFSTVWLCKDLKC---------------------------- SRPK_b_Smoe ------DGRYLVRKKLGWGHFSTVWLSSDRHNENVAGSSDLSLIF--------------- SRPK_d_Smoe ------GGRYVVQRKVGWGHFSTVWLAWDTQQK--------------------------- SRPK_a_Smoe ------GGRYVVQRKVGWGHFSTVWLAWDTQQK--------------------------- SRPK_c_Smoe ------DGRYLVRKKLGWGHFSTVWLSSDRHNE--------------------------- GK042_Glam -------DRYKVLRKIGYGKFSTVWAAVDMVSG--------------------------- : *:* * ...* SRPK2_Hsap -----KRFVAMKVVKSAQ--HYTE---TA---------LDEIKLLKCVRE--SDP----- SRPK1_Hsap -----KKFVAMKVVKSAE--HYTE---TA---------LDEIRLLKSVRN--SDP----- MSSK1_Hsap -----KRFVALKVVKSAG--HYTE---TA---------VDEIKLLKCVRD--SDP----- MSSK1_Mmus -----KRFVALKVVKSAG--HYTE---TA---------VDEIKLLKCVRD--SDP----- SKY1_Scer -----NTHVAMKIVRGDK--VYTE---AA---------EDEIKLLQRVND--ADNTKE-- CG8565_Dmel -----DRYCAVKVSKSAQ--VYKE---TG---------IDEIMLFSQMSL--HDQ----- SRPK_Dmel -----MGYVAIKIVKSAP--HFAE---TA---------RDEIKILKTVRE--TDP----- SRPK1_Mmus -----KKFVAMKVVKSAE--HYTE---TA---------LDEIRLLKSVRN--SDP----- SRPK2_Mmus -----KRFVAMKVVKSAQ--HYTE---TA---------LDEIKLLKCVRE--SDP----- spk-1_Cele -----KRFVAMKIVKSAE--HYTE---AA---------LDEIKLLLSVRS--ADP----- Sky1_Ddis GNVIGYKQVALKIVRSAR--TYSE---TA---------EDEIKILNAISK--YNA----- 13234_Tthe -----DSNVALKIQKSKK--SYQE---AA---------VDELQLLGDLRK--NEKNEKWL 22244_Tthe -----DTYVALKIQKSAP--HYLE---AA---------YDEVEILQKVAK--QASNPQWI 3884_Tthe -----DTYVALKIQKSAP--HYLE---AA---------FDEVEILQKVAR--MSKDPEWM SRPK_Spur -----RRYVALKVVKSAE--HYTE---TA---------LDEIKLLKCVRN--SDP----- CG11489_Dmel -----EKYVALKVVKSAP--HYIE---TA---------ADEIRLLEAIRD--ADP----- CC1G_15433_Ccin -----HQHVTVKIGTP-------R---AL---------ENELRVLKHLKS--LNS----- CC1G_02719_Ccin --DSKPLYVAIRILSAVCSAYVVQ---GP---------SYELYALGWLQD--TDEP---- CC1G_05630_Ccin --PDAASLVALKVMAA----HFSDRPPSA---------MQELLVPEKLHALFSES----- CC1G_06188_Ccin ------AYHALKILNHYG--TLLE---AGEVDDPRRPRFFEREILARVSA--SD------ CC1G_13566_Ccin -----AQYHALKVFKASA--SNQQ---EA----------DRFYTLVRAMS--AMT----- CC1G_09673_Ccin -----STYSALKIYTAAA--SREE---RG---------LAEEKRLVELRD--VMA----- CC1G_10260_Ccin ------VHSALKVVKSAG--RYAE---TA---------RDEIKLLSRVAS--VSP----- CC1G_04899_Ccin ------RHVALKIVKSAP--RYTE---TA---------LDEIKLLQRLIT--SSTPPVAP AqueK134_Aque -----GRFVALKVVKSAK--QYME---AS---------LDEIELLRKVAT--ANR----- SRPK_b_Smoe --SFFQKNIALKIQKSAQ--HYTE---AA---------MDEITILTQISK--GDP----- SRPK_d_Smoe ------SYVALKVQKSAK--HYTE---AA---------FDEISILKQIAD--GDP----- SRPK_a_Smoe ------RYVALKVQKSAK--HYTE---AA---------FDEISILKQIAD--GDP----- SRPK_c_Smoe -----NKNIALKIQKSAQ--HYTE---AA---------MDEITILTQISK--GDP----- GK042_Glam ------TLRAIKISRSNP--EDWN---VA---------RNEYDVMCKIHS--KVSELF-- :::: . SRPK2_Hsap ------------------------------------------------------------ SRPK1_Hsap ------------------------------------------------------------ MSSK1_Hsap ------------------------------------------------------------ MSSK1_Mmus ------------------------------------------------------------ SKY1_Scer ------------------------------------------------------------ CG8565_Dmel ------------------------------------------------------------ SRPK_Dmel ------------------------------------------------------------ SRPK1_Mmus ------------------------------------------------------------ SRPK2_Mmus ------------------------------------------------------------ spk-1_Cele ------------------------------------------------------------ Sky1_Ddis ------------------------------------------------------------ 13234_Tthe SFIKEMKE-----------K--------------------------------------YP 22244_Tthe HQLKEYYKDQTRSAKQNENSDRAISKRFYKQAATALITKKQKKQIIYNLKLKITKQLNKP 3884_Tthe KSLQKYY----------------------------------------------------- SRPK_Spur ------------------------------------------------------------ CG11489_Dmel ------------------------------------------------------------ CC1G_15433_Ccin ------------------------------------------------------------ CC1G_02719_Ccin ------------------------------------------------------------ CC1G_05630_Ccin ------------------------------------------------------------ CC1G_06188_Ccin ------------------------------------------------------------ CC1G_13566_Ccin ------------------------------------------------------------ CC1G_09673_Ccin ------------------------------------------------------------ CC1G_10260_Ccin ------------------------------------------------------------ CC1G_04899_Ccin TP-----------------E--------------------------------------NP AqueK134_Aque ------------------------------------------------------------ SRPK_b_Smoe ------------------------------------------------------------ SRPK_d_Smoe ------------------------------------------------------------ SRPK_a_Smoe ------------------------------------------------------------ SRPK_c_Smoe ------------------------------------------------------------ GK042_Glam ------------------------------------------------------------ SRPK2_Hsap --------SDPN-KDM-VVQLIDDFKIS-GMNGIHVCMVFEVLGHHLL---KWIIKSN-- SRPK1_Hsap --------NDPN-REM-VVQLLDDFKIS-GVNGTHICMVFEVLGHHLL---KWIIKSN-- MSSK1_Hsap --------SDPK-RET-IVQLIDDFRIS-GVNGVHVCMVLEVLGHQLL---KWIIKSN-- MSSK1_Mmus --------SDPK-RET-IVQLIDDFRIS-GVNGVHVCMVLEVLGHQLL---KWIIKSN-- SKY1_Scer --------DSMG-ANH-ILKLLDHFNHK-GPNGVHVVMVFEVLGENLL---ALIKKYE-- CG8565_Dmel ---------HKY-RSH-VVGFYDFFEIT-GPHGRHICLVLEVLGDNLL---KVIERCF-- SRPK_Dmel --------SNPR-RHK-TVQMLDDFKIT-GVNGTHICMVFEVLGDNLL---KLIRKSN-- SRPK1_Mmus --------NDPN-GEM-VVQLLDDFKIS-GVNGTHICMVFEVLGHHLL---KWIIKSN-- SRPK2_Mmus --------SDPN-KDM-VVQLIDDFKIS-GMNGIHVCMVFEVLGHHLL---KWIIKSN-- spk-1_Cele --------NDIG-CHK-VVQLLDEFTVT-GINGQHVAMVFEVLGCNLL---KLIIRSN-- Sky1_Ddis -----------Q-DKC-VARLLDHFTHR-GPNGRHYCMVFELLGNNLL---DLIKHHR-- 13234_Tthe ----DCTEFNEN-EQY-CVKLLDNFVHF-GVHGKHYCSTFEIMGPNLL---DLIQHFDD- 22244_Tthe LNDKQKKTFTRD-DCQ-VVQLLNSFVFR-GPYGNHFCMVFEILGVNLL---EIIKRYN-- 3884_Tthe -EGEKRKSFNKD-DCQ-VVQLLNSFVFK-GPYGNHFCFVFEILGVNLL---EVIKRYN-- SRPK_Spur --------NDIQ-RER-VVQLVDDFKVT-GVNGSLSTAPLERKP---------------- CG11489_Dmel --------MDVK-RER-IVRLMNHFTVR-GVNGMHTCLVFEALGCSLY---KLIVKNN-- CC1G_15433_Ccin --------KHFG-ASA-TRPLIDEFAIE-GADGVFRCAVHPPLAAPISTFRKALLRTG-- CC1G_02719_Ccin ------AISHPG-RSY-CSLAKDHFLYI-SVHGCHLAFVFEPHSLNLQ---DYIL----- CC1G_05630_Ccin --------RHPV-KDH-IHRIHRHFTET-GPNGTHLCLVAPFCGPSLL---AVADNLSY- CC1G_06188_Ccin --------VAPG-AKY-CMKLLESFHIE-RETGKHLCLVMELGGMSVE---DMRPL---I CC1G_13566_Ccin --------IDPN------PRFMGYFWEE-SSHGRHLCFLMAPHCGLSI---EDIRQAN-- CC1G_09673_Ccin --------YSSG-YSK-HPCHFSTWWEE-STRGRHLCYLVEPYCGLSL---EDVRNGD-- CC1G_10260_Ccin --------DHPG-RAH-IVSFLDSFSHQ-GPESSHICIVFEPLGENLL---ALIERNK-- CC1G_04899_Ccin NPPPSPSHTHPG-KSH-VIQFLDHFRHK-GPNGTHVCMVFEVLGENLL---GLIKRHQ-- AqueK134_Aque --------ANPG-LKH-VVEMYDSFRIS-GPHGNHMVMVFEVLGCNLL---RPIIKYN-- SRPK_b_Smoe --------E--N-KKC-VVKLLDHFRHT-GPNGQHVCLVFELLGDNLL---TLIKRHD-- SRPK_d_Smoe --------S--N-SKC-VVKLLDHFKHS-GPNGQHVCMVFEFLGDNLL---TIIKLYN-- SRPK_a_Smoe --------S--N-SKC-VVKLLDHFKHS-GPNGQHVCMVFEFLGDNLL---TIIKLYN-- SRPK_c_Smoe --------E--N-KKC-VVKLLDHFRHT-GPNGQHVCLVFELLGDNLL---TLIKRHN-- GK042_Glam ------SDSFPSIEALPLQAVYDVFRHPAPPNSKHVCLVVEFLGCSTY---RFLQQYTRR : . SRPK2_Hsap ---YQG--L----PVRCVKSIIRQVLQGLDYLHSK-CKIIH------------------- SRPK1_Hsap ---YQG--L----PLPCVKKIIQQVLQGLDYLHTK-CRIIH------------------- MSSK1_Hsap ---YQG--L----PVPCVKSIVRQVLHGLDYLHTK-CKIIH------------------- MSSK1_Mmus ---YQG--L----PVPCVKSIVRQVLHGLDYLHTK-CKIIH------------------- SKY1_Scer ---HRG--I----PLIYVKQISKQLLLGLDYMHRR-CGIIH------------------- CG8565_Dmel ---YKG--M----PISNIKQIAQQVLTGLKFLHEE-CGIIH------------------- SRPK_Dmel ---YRG--I----PLANVKTITRQVLEGLDYLHTC-CKIIH------------------- SRPK1_Mmus ---YQG--L----PLPCVKKIIQQVLQGLDYLHTK-CRIIH------------------- SRPK2_Mmus ---YQG--L----PVRCVKSIIRQVLQGLDYLHSK-CKIIH------------------- spk-1_Cele ---YRG--L----HLEQVRKICRQVLEALGYMHEK-CGIIH------------------- Sky1_Ddis ---YRG--M----PITLVKTLMKQTLIALDYIHTK-CKIIH------------------- 13234_Tthe --YKKN--M----KYWLVRQIARQCLIGLVYLHDV-CGMIH------------------- 22244_Tthe ---YKG--I----PMHLARIIAKQVLIGLDFLHRY-CGVIH------------------- 3884_Tthe ---YSG--V----PMHLCRKIAKQVLIGLDFLHRF-CDVIH------------------- SRPK_Spur ------------------------------------------------------------ CG11489_Dmel ---YQG--L----AIAQVRNIIRQVLEGLDYLHSK-CSIIH------------------- CC1G_15433_Ccin ---MGG--L----PVPLVKALVTYLLEAVDFLHSE-AKVVH------------------- CC1G_02719_Ccin REKTQNPGLQYLFSLDGIKNIIRQTLLALSYVHAR--QLIH------------------- CC1G_05630_Ccin -RYHRR--I----EGRVARRLAKQAALVIERMHSA--GMVHGGSCFDVSVRPILTQCLFR CC1G_06188_Ccin GTNY-S--M----PTAFVKTIVKQMCKALDYLHEE-CRVVH------------------- CC1G_13566_Ccin --TDGR--L----PVHTTQYILSAVAGTLLELQAKGKNIMH------------------- CC1G_09673_Ccin --PMGR--L----PIRTVQFVFNELVEKLSEVHGF-ADGMH------------------- CC1G_10260_Ccin ---KKG--V----PKALVKIIAKQVLLGLQYLHDE-CDLVH------------------- CC1G_04899_Ccin ---SKG--V----PMHLVKQIAKQILLGLDYMHRC-CGVIH------------------- AqueK134_Aque ---YKG--L----PPSFVKLVTKQVLLGLDYLHTE-CGIIH------------------- SRPK_b_Smoe ---CRG--L----PLQVVREISAQVLVGLDYLHRE-LSIIH------------------- SRPK_d_Smoe ---YRG--L----PLPMVKQLSMQILIGLDYLHRQ-LSIIH------------------- SRPK_a_Smoe ---YRG--L----PLPMVKQLSMQILIGLDYLHRQ-LSIIH------------------- SRPK_c_Smoe ---CRG--L----PLQVVREISAQVLVGLDYLHRE-LSIIH------------------- GK042_Glam RSSRPA--I----PVPIVKTFARHLLVALGYVHAA--GYVH------------------- SRPK2_Hsap --TDIK----PENILMCVDD----AY---VR--RMAAEATEWQKAG-APP--------PS SRPK1_Hsap --TDIK----PENILLSVNE----QY---IR--RLAAEATEWQRSG-APP--------PS MSSK1_Hsap --TDIK----PENILLCVGD----AY---IR--RLAAEATEWQQAG-APP--------PS MSSK1_Mmus --TDIK----PENILLCVGD----AY---IR--RLAAEATEWQQSG-AQP--------PS SKY1_Scer --TDIK----PENVLMEIGD----VE---GI--VQMVEALDKQKRE-A----KRLQRHVS CG8565_Dmel --TDLK----PENVLLASNE----VS---VR--TEIKTAIEVYLKA-N------------ SRPK_Dmel --TDIK----PENVLLCVDE----PH---VR--SLATEATQLYCMN-S-K--------MY SRPK1_Mmus --TDIK----PENILLSVNE----QY---IR--RLAAEATEWQRSG-APP--------PS SRPK2_Mmus --TDIK----PENILMCVDD----AY---VR--RMAAEATEWQKAG-APP--------PS spk-1_Cele --TDIK----PENVLITMSR----EE---IK--IMAQHAVVARKMN-M-K--------MS Sky1_Ddis --TDLK----PENVLLEKSF----DF---FT--SNDYIWSE--KYG-YF--KN------- 13234_Tthe --TDLK----PENVMLQLNE----DY---YH--QFIEQVKKLDKKP-MS--MYYLKKQQQ 22244_Tthe --TDLK----PENVLLCLTQ----EE---IK--AHGIKIDEV---P-IL--DPQEE---Q 3884_Tthe --TDLK----PENVLLQLTQ----DE---LK--DIIENGQMTK-NQ-LF--KERLKVI-R SRPK_Spur ------------------------------------------------------------ CG11489_Dmel --TDIK----PENILLVIDN----AA---AMNQQIDDEINSLRVKG-VDF--------PD CC1G_15433_Ccin --TDIQ----ESNILLGLNP----ET---AT--ADLQKFED------------------- CC1G_02719_Ccin --TDLATDVKWSNIFLDQGN----QDDAIIK--YLIQNPS-------KAY--------P- CC1G_05630_Ccin NFTDIT----TSNMLFRLKE----S----VQ--AMSDDAICAQL-G-E-P--------VT CC1G_06188_Ccin --TDLK----PSNILVTFSP----KD---TQ--ELIDMTLKHR--PVERY---------- CC1G_13566_Ccin --GSIA----AENIVFGASS----H----PQ--HLDPLLT---------K--------PE CC1G_09673_Ccin --GSLS----AENAVFWTWA----D----VK--YLKPHLS---------L--------PE CC1G_10260_Ccin --TDIK----PENICFTKSTCLEVTS---VR--QTLEELDELTRSG-IPIQMKGKEKEPE CC1G_04899_Ccin --TDLK----PENVLICIDD----VE---NV--ILA-ELEASSAAA-ST--------PPT AqueK134_Aque --TDIK----PENILFCVSD----EH---VK--SLARNRVS------------------S SRPK_b_Smoe --TDLK----PENILLTTPL----PK---AR--VFDHK---------------------- SRPK_d_Smoe --TDLK----PENVLLTLPL----DP---SK--DPLKSGAPLILS---K----------- SRPK_a_Smoe --TDLK----PENVLLTLPL----DP---SK--DPLNDGAP------------------- SRPK_c_Smoe --TDLK----PENILLTMPL----PK---AR--VFDHK---------------------- GK042_Glam --TDVK----PENLCLKYTL----SE---LR--TLDTPVFDCRLRTTAVA--------PS SRPK2_Hsap G-SAV---------------STAPQ---------------QK---------------P-- SRPK1_Hsap G-SAV---------------STAPQ---------------PK---------------P-- MSSK1_Hsap R-SIV---------------STAPQ---------------EV------L--------Q-- MSSK1_Mmus R-STV---------------STAPQ---------------EV------L----------- SKY1_Scer R--SS---------------DI---TANDSSDEKWAECQTSMPCG--------------- CG8565_Dmel ----------------------EGK---------------LS---------------P-- SRPK_Dmel P-SLV---------------SRAPK---------------EYR---EPP--------I-- SRPK1_Mmus G-SAV---------------STAPQ---------------PK---------------P-- SRPK2_Mmus G-SAV---------------STAPQ---------------QK---------------P-- spk-1_Cele G-SAV---------------STAPD---------------HLV----KM--------A-- Sky1_Ddis ------------------------------------------------------------ 13234_Tthe K--QS---------------KQ-------------------------------------- 22244_Tthe K--QN---------------GH-------------------------------------- 3884_Tthe K--HL---------------GV-------------------------------------- SRPK_Spur ------------------------------------------------------------ CG11489_Dmel S-YIS---------------SIEKQ---------------T------KSRAKWPLIEP-- CC1G_15433_Ccin ------------------------------------------------------------ CC1G_02719_Ccin ----V---------------RFA------------------------------------- CC1G_05630_Ccin E----------------------------------------------------------- CC1G_06188_Ccin ------------------------------------------------------------ CC1G_13566_Ccin I-ISV------------------------------------------------------- CC1G_09673_Ccin G-STI------------------------------------------------------- CC1G_10260_Ccin G-LSA---------------GSSPLK----------------PSSWIEQ--------A-- CC1G_04899_Ccin R--LV---------------GVPPS----------------------------------- AqueK134_Aque K-SAV---------------CNAPS---------------SLS----KS--------G-- SRPK_b_Smoe ------------------------------------------------------------ SRPK_d_Smoe ------------------------------------------------------------ SRPK_a_Smoe ------------------------------------------------------------ SRPK_c_Smoe ------------------------------------------------------------ GK042_Glam TADFVSLSGLEQMEIAAYLQSVSPQ---------------TT------V--------RSD SRPK2_Hsap -------------------IGKISKNK--KK--KLKKKQKR---QAELLEKRLQE----- SRPK1_Hsap -------------------ADKMSKNK--KK--KLKKKQKR---QAELLEKRMQE----- MSSK1_Hsap -------------------TGKLSKNK--RK--KMRRKRKQ---QKRLLEERLRD----- MSSK1_Mmus -------------------IGKLSKNK--RK--KMRRKRKQ---QKRLLEERLRD----- SKY1_Scer ---------------------SSSNSK--SRS--IEKD-----LSKRC------------ CG8565_Dmel -------------------SSKMTKTA--KR--RMQAKSKK---VISFFKNHRRMLRRQG SRPK_Dmel -------------------TGKMSKNR--KK--KLKKKAKK---RMELFKQQRDY----- SRPK1_Mmus -------------------ADKMSKNK--KK--KLKKKQKR---QAELLEKRMQE----- SRPK2_Mmus -------------------IGKISKNK--KK--KLKKKQKR---QAELLEKRLQE----- spk-1_Cele -------------------QENMTKNK--KK--KMKKKAKK---QREKLEAELAG----- Sky1_Ddis ---------------------R-------TSS--SNKQ-----SQ--------------- 13234_Tthe ---------------------TAKKDK--KKE--KKKK-----KKQ-------------- 22244_Tthe ----------------------SQKEN--HSN--CNGQ-----QKT-------------- 3884_Tthe ----------------------KEEEE--KP---V--E-----EKK-------------- SRPK_Spur -------------------QEKMSKNK--KR--KMKKKQKK---QLALLEKQQQQ----- CG11489_Dmel -------------------NGSTNTNTNTSN--STATNSNS---STPLAAVIMST----- CC1G_15433_Ccin ------------------------------E--EIQ------------------------ CC1G_02719_Ccin ------------------------------------------------------------ CC1G_05630_Ccin ------------------------------------------------------------ CC1G_06188_Ccin ------------------------------------------------------------ CC1G_13566_Ccin --------------------KGTAVVR--SQ--PIPA----------------------- CC1G_09673_Ccin --------------------DGVAKIK--AQ--PLMQ----------------------- CC1G_10260_Ccin -------------------SSLSSSYK--SKGSPFKSSKPRSSNRH-------------- CC1G_04899_Ccin ------------------------------KG--------RGGNQT-------------- AqueK134_Aque -------------------GGPMTKNQ--KK--RLKKKLKK---HQELMVKEESM----- SRPK_b_Smoe -------------------------NK--SRAE----------ENT-------------- SRPK_d_Smoe -------------------------PA--AAAA----------AAT-------------- SRPK_a_Smoe ------------------------------------------------------------ SRPK_c_Smoe -------------------------KK--SRAE----------ENT-------------- GK042_Glam HHGSLDDLLDNTSLQVVEGPGNIYSSS--SY--PLHD-ALY---AADLLFRIVPY----- SRPK2_Hsap IEELEREAE-RK---------------------IIE----------------ENI---T- SRPK1_Hsap IEEMEKESG-PG---------------------QKR----------------PNK---Q- MSSK1_Hsap LQRLEAMEA-AT------------------------------------------------ MSSK1_Mmus LQRLEAMEA-AV------------------------------------------------ SKY1_Scer ---------------------------------FRR----------------PRR---HT CG8565_Dmel IEDLLYLAE-RG---------------------LIE----------------P-I---T- SRPK_Dmel LEQADGQGA-INPNEVQNGDAGISDADEYFDANSVE----------------DNV---H- SRPK1_Mmus IEEMEKESG-PG---------------------QKR----------------PNK---Q- SRPK2_Mmus IEELEREAE-RK---------------------ILE----------------ENI---T- spk-1_Cele LEGLKMDA------------------------NGLQ----------------EAY---N- Sky1_Ddis ------------------------------------------------------------ 13234_Tthe ----------------------------------------------------EA-----A 22244_Tthe ----------------------------------------------------DS-----Q 3884_Tthe ----------------------------------------------------PQ-----Q SRPK_Spur LQEIDQEKT-RT---------------------ISE----------------TSQ---P- CG11489_Dmel LDKEDTTTTTSS---------------------TLN----------------SNT---T- CC1G_15433_Ccin ------------------------------------------------------------ CC1G_02719_Ccin ------------------------------------------------------------ CC1G_05630_Ccin ------------------------------------------------------------ CC1G_06188_Ccin ------------------------------------------------------------ CC1G_13566_Ccin ------------------------------------------------------------ CC1G_09673_Ccin ------------------------------------------------------------ CC1G_10260_Ccin ----------------------------------------------------GH-----S CC1G_04899_Ccin ----------------------------------------------------PR-----S AqueK134_Aque ISDVDAVTT-ET------------------------------------------------ SRPK_b_Smoe ----------------------------------------------------DA-----T SRPK_d_Smoe ----------------------------------------------------AT-----A SRPK_a_Smoe ------------------------------------------------------------ SRPK_c_Smoe ----------------------------------------------------DA-----T GK042_Glam PDNLERKFG-LL---------------------IDETSLSKTAIHLDALYSYKNIPSTEE SRPK2_Hsap S-A--APSND--------------------------------QDGEY------------- SRPK1_Hsap E-E--SESPV--------------E-----------------RPLKE------------- MSSK1_Hsap ------------------------------------------------------------ MSSK1_Mmus ------------------------------------------------------------ SKY1_Scer -I-----------------------------------------ITGS------------- CG8565_Dmel A-A--MAVS------------------------------------DN------------- SRPK_Dmel V-AAGQPSRK--------------Q-----------------RDERK------------- SRPK1_Mmus E-E--SESPV--------------D-----------------RPLTE------------- SRPK2_Mmus S-A--EASGE--------------Q-----------------QDGEY------------- spk-1_Cele N-A---P-----------------Q-----------------NGVRM------------- Sky1_Ddis --------------------------------------------QQQ------------- 13234_Tthe -A-----------------------------------------AAAA------------- 22244_Tthe -N-----------------------------------------QSAQ------------- 3884_Tthe -Q------------------------------------------QQA------------- SRPK_Spur D-A--DRDGEDNVATDAVPQNQSNN-----------------GNQSL------------- CG11489_Dmel S-S--LASKY--------------SSLLGDSECNGGLGGSANINNRY------------- CC1G_15433_Ccin ------------------------------------------------------------ CC1G_02719_Ccin ------------------------------------------------PGL-TTEPVMEV CC1G_05630_Ccin ------------------------------------------------------------ CC1G_06188_Ccin -----------------------------------------------PPRRVLGETIRAM CC1G_13566_Ccin ------------------------------------------------------------ CC1G_09673_Ccin ---------------------------------------------VE------------- CC1G_10260_Ccin HSQ--SGAPW--------------Q-----------------DPGVA------------- CC1G_04899_Ccin ES---------------------------------------------------------- AqueK134_Aque ------------------------------------------------------------ SRPK_b_Smoe ------------------------------------------------------------ SRPK_d_Smoe ------------------------------------------------------------ SRPK_a_Smoe ------------------------------------------------------------ SRPK_c_Smoe ------------------------------------------------------------ GK042_Glam SQEQFWNSLTSICKTVLLKLRGTTSSPFNICIETTQQTKEADVDGDVQPQRILKKASTTL SRPK2_Hsap -CP-EV-----KLKTTGLE---EAA-------------------------EAET------ SRPK1_Hsap -NP-PN-----KMTQEKLE---ESS----------------------------------- MSSK1_Hsap ------------------------------------------------------------ MSSK1_Mmus ------------------------------------------------------------ SKY1_Scer -QPLPS-------------------PIS--SSNFFEMRAHFCGSSHNS-FS--------- CG8565_Dmel -LP-FI------------------------------------------------------ SRPK_Dmel -AP-PE-----QS-----E---EAQ-------------------------EQD------- SRPK1_Mmus -NP-PN-----KMTQEKLE---ESN----------------------------------- SRPK2_Mmus -QP-EV-----TLKAADLE---DTT-------------------------EEET------ spk-1_Cele -RP-PS-----LL-----F---N-----------------------------G------- Sky1_Ddis -Q--PQ-------------------QQQ-SQ------------QNIND-YS--------- 13234_Tthe -VTQAT-------------------NQTQDQNSTNNTTT--------------------- 22244_Tthe -NPNPQ-------------------KQE--QNDKNNLAS----KQEQDQQN--------- 3884_Tthe -K--PD-------------------QKT--K------------KQQEDDDN--------- SRPK_Spur -SP-SE-----DKMAEVLE---EAE-------------------------EEEDGAVSRM CG11489_Dmel -RT-EK-----KITAKSSGDCDEDA-------------------------ESD------- CC1G_15433_Ccin -NPSPR------------------------------------------------------ CC1G_02719_Ccin ------------------------------------------------------------ CC1G_05630_Ccin ------------------------------------------------------------ CC1G_06188_Ccin ------------------------------------------------------------ CC1G_13566_Ccin --RNPQ------------------------------------------------------ CC1G_09673_Ccin -NPDPK------------------------------------------------------ CC1G_10260_Ccin -SPAPA-----VL-VNAVA---SADGQETSQTAFNSLRT---------SSS--------- CC1G_04899_Ccin ------------------------------------------------------------ AqueK134_Aque ------------------------------------------------------------ SRPK_b_Smoe ------------------------------------------------------------ SRPK_d_Smoe ------------------------------------------------------------ SRPK_a_Smoe ------------------------------------------------------------ SRPK_c_Smoe ------------------------------------------------------------ GK042_Glam RAPLPRINDDEHICVHLLD---EAT----------------------------------- SRPK2_Hsap ----------------------------------AKDN-G--E---------------AE SRPK1_Hsap ---------------------------------------T--I---------------GQ MSSK1_Hsap ------------------------------------------Q---------------AE MSSK1_Mmus ------------------------------------------Q---------------AE SKY1_Scer ------------------------------------------S---------------VS CG8565_Dmel ---------------------------------------P--FGFDGFMMMSDADCRTVQ SRPK_Dmel ---------------------------------------PLTE---------------GT SRPK1_Mmus ---------------------------------------S--I---------------GQ SRPK2_Mmus ----------------------------------AKDN-G--E---------------VE spk-1_Cele ---------------------------------------PIPQ----------------- Sky1_Ddis ------------------------------------------D---------------DS 13234_Tthe ----------------------------------------------------------VS 22244_Tthe ------------------------------------------E---------------DE 3884_Tthe ------------------------------------------D---------------ND SRPK_Spur KATKSPERTSEISSPEEEQPGVVVGENATNGNEGAGCHGD--E---------------AE CG11489_Dmel ---------------------------------------T--L---------------GE CC1G_15433_Ccin ------------------------------------------------------------ CC1G_02719_Ccin ------------------------------------------------------------ CC1G_05630_Ccin ------------------------------------------------------------ CC1G_06188_Ccin ------------------------------------------------------------ CC1G_13566_Ccin ------------------------------------------------------------ CC1G_09673_Ccin ------------------------------------------------------------ CC1G_10260_Ccin ------------------------------------------S---------------TS CC1G_04899_Ccin ------------------------------------------------------------ AqueK134_Aque ------------------------------------------------------------ SRPK_b_Smoe ------------------------------------------------------------ SRPK_d_Smoe ------------------------------------------------------------ SRPK_a_Smoe ------------------------------------------------------------ SRPK_c_Smoe ------------------------------------------------------------ GK042_Glam ---------------------------------------V--I---------------SI SRPK2_Hsap DQE-------E--------KEDAEK---------------ENIE-------KDE------ SRPK1_Hsap DQT-------L--------M-----------------------E-------RDT------ MSSK1_Hsap DSG-------L--------R----------------------LD-------GG------- MSSK1_Mmus DSS-------S--------R----------------------LE-------RG------- SKY1_Scer GNR-NIPSSI-N-------NN--------------------------------------- CG8565_Dmel NSK-------LPEMEGMEYKC----------------------DRINLCLKS-------- SRPK_Dmel DKA-------K--------KKKK-------------------KK-------NK------- SRPK1_Mmus DQT-------L--------T-----------------------E-------RGG------ SRPK2_Mmus DQE-------E--------KEDAEK---------------ENAE-------KDE------ spk-1_Cele ------------------------------------------LL-------QG------- Sky1_Ddis DDS-HSDYS-DS-------ED--------------------------------------- 13234_Tthe EQT-IIETSTNE-------NK----------------------E-------LN------- 22244_Tthe DDN-DNDND-DE-------QE----------------------E-------GA------- 3884_Tthe DED-GEDDDGNQ-------KD----------------------E-------GD------- SRPK_Spur DAD-------V--------FEDAPERIPSPVNEKGDGPGRKEVE-------KEQELCNGY CG11489_Dmel QSTLA-----S--------T----------------------MD-------SP------- CC1G_15433_Ccin ------------------------------------------------------------ CC1G_02719_Ccin ------------------------------------------------------------ CC1G_05630_Ccin ------------------------------------------------------------ CC1G_06188_Ccin ------------------------------------------------------------ CC1G_13566_Ccin ------------------------------------------------------------ CC1G_09673_Ccin ------------------------------------------------------------ CC1G_10260_Ccin TIT-------IA-------HS----------------------E-------SS------- CC1G_04899_Ccin ------------------------------------------------------------ AqueK134_Aque DSV-------S--------M---------------------------------------- SRPK_b_Smoe ------------------------------------------------------------ SRPK_d_Smoe ------------------------------------------------------------ SRPK_a_Smoe ------------------------------------------------------------ SRPK_c_Smoe ------------------------------------------------------------ GK042_Glam DAL--------------------------------------------------------- SRPK2_Hsap -----D-D------------------------V--DQ----------------------- SRPK1_Hsap -----E-G------------------------G--AA----------------------- MSSK1_Hsap -----S-G------------------------S--T------------------------ MSSK1_Mmus -----S-G------------------------S--T------------------------ SKY1_Scer -------------SINNGIGIK--N---SNN----------------------------- CG8565_Dmel ------------------------------------------------------------ SRPK_Dmel -----N-K------------------------S--N------------------------ SRPK1_Mmus -----E-G------------------------G--AP----------------------- SRPK2_Mmus -----D-D------------------------V--EQ----------------------- spk-1_Cele -------S------------------------S--C------------------------ Sky1_Ddis -------------ELKN-KGNK--K----------------------------------- 13234_Tthe -------NQKQ-EEIVK-NLQE--NKETTNNG---------------------------- 22244_Tthe -------TSTAASNQNN-QGDK--KNLTKKQK---------------------------- 3884_Tthe -------NTNL-KELEQ-KLKQ--PGLTKKQK---------------------------- SRPK_Spur VEENGDGD------------------------V--DL----------------------- CG11489_Dmel -----T-D------------------------LDPEP----------------------- CC1G_15433_Ccin ------------------------------------------------------------ CC1G_02719_Ccin ------------------------------------------------------------ CC1G_05630_Ccin ------------------------------------------------------------ CC1G_06188_Ccin ------------------------------------------------------------ CC1G_13566_Ccin ------------------------------------------------------------ CC1G_09673_Ccin ------------------------------------------------------------ CC1G_10260_Ccin -------ST-----T-AT-ATQP---SPTGTPL--GP----------------------- CC1G_04899_Ccin --------V-----F-IT-GSQP---LPSPSS----S----------------------- AqueK134_Aque ------------------------------------------------------------ SRPK_b_Smoe --------G-------KE------------------------------------------ SRPK_d_Smoe --------G-----V-TS-SSQP---LSKSQK---------------------------- SRPK_a_Smoe ------------------------------------------------------------ SRPK_c_Smoe --------G-------KE-GGDEFDGIATN------------------------------ GK042_Glam -------------------SAV--PLL---------KKLAAAELALPVTLKKILLAHKRT SRPK2_Hsap -----E-LA------NID-PTWI------ESP--KTNGHIENGPFSL---EQQ------- SRPK1_Hsap ---------------EI-----------------NCNGVIEVINYTQNSNNET------- MSSK1_Hsap -----S-SS------GCH-PGGA------R------------------------------ MSSK1_Mmus -----S-SS------GCH-PEGT------R------------------------------ SKY1_Scer ------------------------------------------------------------ CG8565_Dmel -------------------PEL------------------------------FLRYVLDI SRPK_Dmel -----Q-SK------GQQ-PPQ-------------------------------------- SRPK1_Mmus ---------------EI-----------------NCNGVIGVVNYPENSNNET------- SRPK2_Mmus -----E-LA------NLD-PTWV------ESP--KANGHIENGPFSL---EQQ------- spk-1_Cele -----V-NTPSSPRTVPPPPPSL-------YPQVGC---VCNQTYHL---TQV------- Sky1_Ddis ------------------------------------------------------------ 13234_Tthe ------------------------------------------------------------ 22244_Tthe ------------------------------------------------------------ 3884_Tthe ------------------------------------------------------------ SRPK_Spur -----PLKP------KLH-PDVK------ENG--LDSA--SSTPTPT---KES------- CG11489_Dmel -----E-L-------DSK-PNTVPEPTTIAKS--KINSNI----LST---CTS------- CC1G_15433_Ccin ------------------------------------------------------------ CC1G_02719_Ccin ------------------------------------------------------------ CC1G_05630_Ccin ------------------------------------------------------------ CC1G_06188_Ccin ------------------------------------------------------------ CC1G_13566_Ccin ------------------------------------------------------------ CC1G_09673_Ccin ------------------------------------------------------------ CC1G_10260_Ccin -----RKTKTMSIING----------------------V-----------SKL------- CC1G_04899_Ccin -----FGTSP-MLDKW-------------------------------------------- AqueK134_Aque --------------------------------------TI---------DNHT------- SRPK_b_Smoe ------------------------------------------------------------ SRPK_d_Smoe ------------------------------------------------------------ SRPK_a_Smoe ------------------------------------------------------------ SRPK_c_Smoe ------------------------------------------------------------ GK042_Glam ADEYLQTHS------IEL-PTCM------SVPI-VLNGYMRGKTLHI---QEG------- SRPK2_Hsap LDD---EDDDEEDC------------PNPEEYNL-------------------------- SRPK1_Hsap LRH-------KEDL------------HNANDCDV-------------------------- MSSK1_Hsap ------------------------------------------------------------ MSSK1_Mmus ------------------------------------------------------------ SKY1_Scer ------------------------------SF--LNSVPHSV------TRMFINEDSND- CG8565_Dmel I-------------------------KNLDEKEL-------------------------- SRPK_Dmel -------------L------------ENST-SSA-------------------------- SRPK1_Mmus LRH-------KEDL------------HNANDCDV-------------------------- SRPK2_Mmus LED---EEDDEDDC------------ANPEEYNL-------------------------- spk-1_Cele ILN---ANVG--EL------------ENFNASQV-------------------------- Sky1_Ddis ------------------------------SS--NRDRDN-------NKNKNIKKDDNK- 13234_Tthe ------------------------------KN--DEKKQENAIDLKENQDQNVQKNNND- 22244_Tthe ------------------------------KN--QRRKAAH-------KRKKQREKEEK- 3884_Tthe ------------------------------KN--LRKKISM-------KKRKLQEQKNA- SRPK_Spur LKNAANKEKSENKA------------SDPNENTI-------------------------- CG11489_Dmel LT-----STNEYCF------------TNTNTTTA-------------------------- CC1G_15433_Ccin ------------------------------------------------------------ CC1G_02719_Ccin ------------------------------------------------------------ CC1G_05630_Ccin ------------------------------------------------------------ CC1G_06188_Ccin ------------------------------------------------------------ CC1G_13566_Ccin ------------------------------------------------------------ CC1G_09673_Ccin ------------------------------------------------------------ CC1G_10260_Ccin ISD---TST----MLSTGLHPTSETKPNTNTTNRTPQSGETN------------------ CC1G_04899_Ccin ---------------AFGMSR-IEGDDNSNGI--VEKKGLST------VKRAVSTDL--- AqueK134_Aque ILP---ESV--------------------------------------------------- SRPK_b_Smoe -------------------------------------------------------EIEA- SRPK_d_Smoe ------------------------------KK--LKKKAAK-------DKTGKDKDMDK- SRPK_a_Smoe ------------------------------------------------------------ SRPK_c_Smoe ------------------------------KS--M-----K-------DREPGKAEIEA- GK042_Glam ------------------L-------DPYNHV--IVNGHQFA------VARKGSVDCIDD SRPK2_Hsap ---------DEP----------NA------------------------------ESDYTY SRPK1_Hsap ---------QNL----------NQ------------------------------ESSFLS MSSK1_Hsap -----------------------A------------------------------GPSPAS MSSK1_Mmus -----------------------A------------------------------GPSPAS SKY1_Scer ----NNNNDNSK----------NKN------------------------------NNNNN CG8565_Dmel ---------STQ----------DKR------------------------------RRFTQ SRPK_Dmel ---------ESS----------SA----------------------------------LK SRPK1_Mmus ---------HTL----------KQ------------------------------EPSFLN SRPK2_Mmus ---------DEP----------NA------------------------------ESDYTY spk-1_Cele ---------EDV----------TM----------------------------------ED Sky1_Ddis ---SSVNEINNI----------SKE------------------------------NTDNK 13234_Tthe -NAQEKVETNST----------NKQ------------------------------EDSQE 22244_Tthe -N-KQTNDQDSN----------K------------------------------------- 3884_Tthe -Q-QQPQEQQST----------K------------------------------------- SRPK_Spur ---------SEN----------ST------------------------------ESKDKE CG11489_Dmel ---------STP----------SA------------------------------PPSATP CC1G_15433_Ccin ------------------------------------------------------------ CC1G_02719_Ccin ------------------------------------------------------------ CC1G_05630_Ccin ------------------------------------------------------------ CC1G_06188_Ccin ------------------------------------------------------------ CC1G_13566_Ccin ------------------------------------------------------------ CC1G_09673_Ccin ------------------------------------------------------------ CC1G_10260_Ccin ---V---TTNHV----------SLLT----------------------------QTA-PT CC1G_04899_Ccin -V-A---EVNNV----------SLET----------------------------QASYVG AqueK134_Aque ------------------------------------------------------------ SRPK_b_Smoe -F-QDA--WKNI----------GLD------------------------------KSCLE SRPK_d_Smoe -A-AEA-MVATV----------DAT------------------------------AAAVE SRPK_a_Smoe ------------------------------------------------------------ SRPK_c_Smoe -F-QDA--WKNI----------GLD------------------------------KSCLE GK042_Glam IV-V---ELKHFDPRKAASIAVYKQSRYAFSSYLAMLNCCYDDYYMSDHHHINIGGSFTS SRPK2_Hsap S---SSYEQFNGELPNGRHKIPESQFPEFSTSLFSGSLE-------PVACGSVLSEG-SP SRPK1_Hsap S---Q-----NG-----DSSTS--QETDSCTPITSEVSD-------TMVCQSSSTVG-QS MSSK1_Hsap S----------SPAPGGGRSL----SAGSQTSGFSGSL---------------------- MSSK1_Mmus S----------SPVPGGERSL----SPSSQTSGFSGSL---------------------- SKY1_Scer ----SNNNNN-E-D-IMN-TPLH-EEQLADSL---------------------------- CG8565_Dmel A--------------SGRGQTK--KNARSRL----------------------------- SRPK_Dmel S-----------QQANGSNSTTN----NKSNTNSSGT----------LKGQSNG--KKMP SRPK1_Mmus S---S-----NG-----DSSPS--QDTDSCTPTASE----------TMVCQSSA--E-QS SRPK2_Mmus S---SSYEQFNGELPNGQHKTSE-----FPTPLFSGPLE-------PVACGSVISEG-SP spk-1_Cele T-----------VNENGNR--------NK------------------------------- Sky1_Ddis DLNSSEENKK-E-E-EQQ-QNKKEEPTTTTT----------------------------- 13234_Tthe KLKQNKEDTK-S-K-NKE-DD--EKKEKENDS---------------------------- 22244_Tthe ------QQNNLN-D-KQA-EG--QKQQIEEEV---------------------------- 3884_Tthe ------ESTK-Q-E-NQA-EE--NKPSQQKEM---------------------------- SRPK_Spur T---L----NNGAKENGNHKTLDNKPSDNVQENKNIELN-------SLGADSMLNGGVSP CG11489_Dmel -----------SSAPALASAT----PPSTCTPSFTQIAPSATAPATSTTCTTS------- CC1G_15433_Ccin ------------------KINEERVTH--------------------------------- CC1G_02719_Ccin ------------------MSQ--------------------------------------- CC1G_05630_Ccin -----------------------------EVI---------------------------- CC1G_06188_Ccin ------------------RSQ--------------------------------------- CC1G_13566_Ccin ------------------------------------------------------------ CC1G_09673_Ccin ------------------------------------------------------------ CC1G_10260_Ccin RISANVEPLR-TTTTRPSP------------P---------------------------- CC1G_04899_Ccin RMPGAPGPSL-LTDTKPVP------------I---------------------------- AqueK134_Aque ------------------------------------------------------------ SRPK_b_Smoe D--------------APSD--------VEKLI---------------------------- SRPK_d_Smoe SGKGGSDG-------APRHEN--HKIHADEAT---------------------------- SRPK_a_Smoe -----------------RHEN--HKIHADEAT---------------------------- SRPK_c_Smoe D--------------APSD--------VEKLI---------------------------- GK042_Glam N---P-----WG-----QSRPP--ARPETCTGEVNG------------------------ SRPK2_Hsap ------L---------TE-QE-----E--S-----SP----------------------S SRPK1_Hsap ------F---------SE-QHISQLQE--SIRAE-IP----------------------C MSSK1_Hsap ------F---------SP-ASCSIL----------------------------------S MSSK1_Mmus ------F---------ST-ASCSIL----------------------------------S SKY1_Scer ------------------------------------ST-------------FD------- CG8565_Dmel ------------------------------------RL---------------------- SRPK_Dmel ------LRPKQEKQGSNHQLN-----NNNS-----KP----------------------N SRPK1_Mmus ------L---------TR-QDITQLEE--SIRAD-TP----------------------S SRPK2_Mmus ------L---------TE-QE-----E--S-----SP----------------------S spk-1_Cele ----------VEIRSPDR-FD-----RTTL-----TP----------------------F Sky1_Ddis -------------------------------------T-------------AT------- 13234_Tthe ------------------------------------DY-------------SD------- 22244_Tthe ------------------------------------KE---------------------- 3884_Tthe ------------------------------------NT---------------------- SRPK_Spur EEDVQTK---------DA-QK-----E--D-----TT----------------------S CG11489_Dmel ----------AEFY--DGDHK-----T--T-----ST----------------------S CC1G_15433_Ccin ------------------------------------------------------------ CC1G_02719_Ccin ------------------------------------------------------------ CC1G_05630_Ccin ------------------------------------TA-------------S-------- CC1G_06188_Ccin ------------------------------------------------------------ CC1G_13566_Ccin ------------------------------------------------------------ CC1G_09673_Ccin ------------------------------------------------------------ CC1G_10260_Ccin -------------------QHISQLSA--HMHSEPCPS-------------LP------S CC1G_04899_Ccin ------------------------------------PG-------------AP------- AqueK134_Aque -EEEDT----METE------------E--------------------------------- SRPK_b_Smoe ------------------------------------CE-------------VK------- SRPK_d_Smoe ------------------------------------GA-------------AD------- SRPK_a_Smoe ------------------------------------GA-------------AD------- SRPK_c_Smoe ------------------------------------CE-------------VK------- GK042_Glam -------------------------------------SNETASMAASFVSTSYSHECSRT SRPK2_Hsap -HDR-S--------------RT--------------------V----------------- SRPK1_Hsap -EDE--------------------------------------Q----------------- MSSK1_Hsap -GSS--------------------------------------N----------------- MSSK1_Mmus -GSS--------------------------------------N----------------- SKY1_Scer -------------------ISN--------------------I--------S-------- CG8565_Dmel ---A-----------------S--------------------N----------------- SRPK_Dmel -SNS--------------------------------------D----------------- SRPK1_Mmus -GDE-------------------------------------------------------- SRPK2_Mmus -HDR-S--------------RT--------------------V----------------- spk-1_Cele -SDP--------------------------------------E----------------- Sky1_Ddis -------------------A-T--------------------A--------T-------- 13234_Tthe -------------------C---------------------------------------- 22244_Tthe ------------------------------------------------------------ 3884_Tthe ------------------------------------------------------------ SRPK_Spur -DDN-R--------------RKEIDLKWEELEKFESKNSGGED----------------- CG11489_Dmel TTTT-S--------------NA--------------------I----------------- CC1G_15433_Ccin ------------------------------------------------------------ CC1G_02719_Ccin ------------------------------------------------------------ CC1G_05630_Ccin ------------------------------------------------------------ CC1G_06188_Ccin ------------------------------------------------------------ CC1G_13566_Ccin ------------------------------------------------------------ CC1G_09673_Ccin ------------------------------------------------------------ CC1G_10260_Ccin -HDS-VLSSHFPSETSRPNFTT--------------------V--------STAIAQRLV CC1G_04899_Ccin ------------------------------------------------------------ AqueK134_Aque ---T-D------------------------------------------------------ SRPK_b_Smoe ------------------------------------------------------------ SRPK_d_Smoe ------------------------------------------------------------ SRPK_a_Smoe ------------------------------------------------------------ SRPK_c_Smoe ------------------------------------------------------------ GK042_Glam -HTRQG---------------SQ-------------------ISSEWSVEHD-------- SRPK2_Hsap -------SA---------------------SS-T-G--D-L-------P-KAKTRAADLL SRPK1_Hsap -------EQ---------------------EH-N-G--P-L----D--N-KGKSTAGNFL MSSK1_Hsap -------QR---------------------ET-G-G--L-L----S--P-STPFGASNLL MSSK1_Mmus -------QR---------------------ET-G-G--L-L----S--P-STPFGASNLL SKY1_Scer -------QS-S-------------------DT-N--G-P-YI---SN----TMDSNSNVS CG8565_Dmel -------AA---------------------YT-T-G--T-GW---R--S-NRKINLN--D SRPK_Dmel -------SK---------------------IS-S-G--S-VENTSS--ATNGPHSNSTLP SRPK1_Mmus --------Q---------------------EP-N-G--A-L----D--S-KGKFSAGNFL SRPK2_Mmus -------SA---------------------SS-T-G--D-L-------P-KTKTRAADLL spk-1_Cele -------SK-FGD-----------------LA-S-P--S-AEYLSS--PMSQLPPGGILP Sky1_Ddis -------TT-T-------------------TT-GTEEFK-FV---NG-I-SYKFKKNNEL 13234_Tthe --------E-S-------------------DS-DR---D-EV---SEEE-LYTLKWKN-- 22244_Tthe ----------------------------------E---D-IP---EE-I-RYKFDNWNG- 3884_Tthe ----------------------------------K---D-LF---SQ-P-DTKLLDKNKL SRPK_Spur -------GK---------------------EG-S-G--S-A--ATS--P-ADSNKDGESV CG11489_Dmel -------SS---------------------AT-T-T--T-A----T--T-TTAIAKLNVH CC1G_15433_Ccin -------------------------------------------------------VSRQ- CC1G_02719_Ccin ------------------------------------------------P----LP----- CC1G_05630_Ccin -------GD-P-------------------PGPD--A-PREL--------VESIQA-SR- CC1G_06188_Ccin ------------------------------------------------P----LP----- CC1G_13566_Ccin -----------------------------------------V--------AD-------- CC1G_09673_Ccin -----------------------------------------S--------TD-------- CC1G_10260_Ccin FGTSSSPAPPPPT-----------------PV-DG-P-V-FG--------SFPISPPPPF CC1G_04899_Ccin -------SPEP-------------------PA-DG-A-P-RS--------VMSVDQRSDS AqueK134_Aque -------QS---------------------TT-N-G--S-S--------------AGSSC SRPK_b_Smoe -------KP-----------------------------P-PL--------ASN------- SRPK_d_Smoe -------AQ-A-------------------PG-E--A-P-RL--------ANKHEKRLK- SRPK_a_Smoe -------AQ-A-------------------PG-E--A-P-RL--------ANKHEKRLK- SRPK_c_Smoe -------KP-----------------------------P-PV--------ASN------- GK042_Glam -------SS-ADGEGIPPFDDAICGCIISSAT-DTA----L----YR-P----IMVAYPD SRPK2_Hsap VNP----------------LDP-RNADKIRVKIADLGNACWVH---KHFTED---IQTRQ SRPK1_Hsap VNP----------------LEP-KNAEKLKVKIADLGNACWVH---KHFTED---IQTRQ MSSK1_Hsap VNP----------------LEP-QNADKIKIKIADLGNACWVH---KHFTED---IQTRQ MSSK1_Mmus VNP----------------LEP-QNADKIKIKIADLGNACWVH---KHFTED---IQTRQ SKY1_Scer --T----------------DIN-SPENLIQIKIADLGNACWYD---EHYTNS---IQTRE CG8565_Dmel IYP----------------IDPANNECDVRVKIADLGNACYFH---HHFTDD---IQTKE SRPK_Dmel TPPPPPQAKHKAK------KDPALDECNVHVKIADLGNACWVD---RHFTED---IQTRQ SRPK1_Mmus INP----------------LEP-KNAEKLQVKIADLGNACWVH---KHFTED---IQTRQ SRPK2_Mmus VNP----------------LDP-RNADKIRVKIADLGNACWVH---KHFTED---IQTRQ spk-1_Cele APPVGPN--------------IGDPYCDIDVKIADLGNACWVN---HHYTDD---IQTRQ Sky1_Ddis ---------------------F-NENHYPRAQLVDLGNACWTD---KHFTDD---IQTRQ 13234_Tthe --K----------------IPI-ALDKSLKIKIVDFGNACWIN---KKFTNN---IQTRE 22244_Tthe -------------------RGD-RLQTNVRVKIADLGNACWTH---HHFATE---IQTRQ 3884_Tthe --M----------------RGP-QLDENFKLKIADLGNACWTF---HHFATE---IQTRQ SRPK_Spur EGA----------------TSP-ERKDELPIKLADLGNACWTH---HHFTED---IQTRQ CG11489_Dmel ANAIPSQNQSQSSQNNTYTIQSLIDNSNVRVKIADLGNACYDY---HHFTED---IQTRQ CC1G_15433_Ccin -------------------LVP-PLYRYGPPTLCDFGEARFGE---YDNMFD---IQPYQ CC1G_02719_Ccin L------------------FEN-PSRNSLTLKLGDFGLAAPALEAKRRGPFP---GTPTD CC1G_05630_Ccin -------------------FIE-FSLVHDSILVSDFGQSFLVD---AM-PEDYHPATTIH CC1G_06188_Ccin LPG----------------FDQ-RNPLTWVFKLTDFGSAQWIG---KRSATV---VQPIR CC1G_13566_Ccin -------------------SME-TMVLNWRLLLTEYKYAQK-G---LALTPE---PEHDY CC1G_09673_Ccin -------------------DLP-TVMKTWQFVFRGFEYAQV-G---SGLKPH---PQHDY CC1G_10260_Ccin --T----------------SQF-PNPPPISIKIADLGNATPSK---KHFTED---IQTRQ CC1G_04899_Ccin --S----------------SAI-DLSEKITVKIADLGNATWVE---HHFTDD---IQTRQ AqueK134_Aque TDS-------------------FDLLGPVSVKIADLGNACWIN---HHFTDD---IQTRQ SRPK_b_Smoe -------------------RKT-SHDVDLRCKIVDLGNACWTY---KQFTAD---IQTRQ SRPK_d_Smoe -------------------VTD-LGELDLRCKIVDLGNACWTY---KQFTND---IQTRQ SRPK_a_Smoe -------------------VTD-LGELDLRCKIVDLGNACWTY---KQFTND---IQTRQ SRPK_c_Smoe -------------------CKT-SHDVDLRCKIVDLGNACWTY---KQFTAD---IQTRQ GK042_Glam TDH----------------LIP-LLPEMFSVKLIDLGNSHRLG---DTQPPL---IQTAP . : SRPK2_Hsap YRSIEVLIGA-GYSTPADIWSTACMAFELATG-DYL-FEPH--SG-EDYSRDEDHI-AHI SRPK1_Hsap YRSLEVLIGS-GYNTPADIWSTACMAFELATG-DYL-FEPH--SG-EEYTRDEDHI-ALI MSSK1_Hsap YRAVEVLIGA-EYGPPADIWSTACMAFELATG-DYL-FEPH--SG-EDYSRDEDHI-AHI MSSK1_Mmus YRAVEVLIGA-EYGPPADIWSTACMAFELATG-DYL-FEPH--SG-EDYSRDEDHI-AHI SKY1_Scer YRSPEVLLGA-PWGCGADIWSTACLIFELITG-DFL-FEPD--EG-HSYTKDDDHI-AQI CG8565_Dmel YRALEVILGA-GYCETADIWSVACLLWELATG-TYL-FDTH--SKRGKYNLDEVHI-AKI SRPK_Dmel YRSLEVIIGA-GYNTSADIWSTACMVFELATG-DYL-FEPH--SG-ESYTRDEDHL-AHI SRPK1_Mmus YRSLEVLIGS-GYNTPADIWSTACMAFELATG-DYL-FEPH--SG-EDYTRDEDHI-ALI SRPK2_Mmus YRSIEVLIGA-GYSTPADIWSTACMAFELATG-DYL-FEPH--SG-EDYSRDEDHI-AHI spk-1_Cele YRALEVLIGS-GYGPPADIWSTACMAFELATG-DYL-FEPH--QG-DNYSRDEDHL-AHI Sky1_Ddis YRAPEAIVKA-KWGTPVDIWSAACMAFELATG-DHL-FKPK--SG-KGFEKSDDHL-ALM 13234_Tthe YRAPETILGI-DYQQNTDVFSFACMIYELITN-DYL-FKPK--KR-DDTTKNDEHL-ALF 22244_Tthe YRSPETIIGV-HYDTTADVWSFACMIFEMLTG-DFL-FEPR--KG-PNFSKNDDHI-AQI 3884_Tthe YRSPEVIIGS-KYNTTADIWSLACMLFEMLTG-DFL-FEPR--KG-PTFSKNDDHL-AQI SRPK_Spur YRALEVLIGA-GYDTAADIWSTACMAFELACG-DYL-FEPH--SG-ENYSRDEDHI-AHI CG11489_Dmel YRSIEVLLGA-PYNYTADIWSTACLAFELATG-DYL-FDPH--AG-ESYSRDEDHL-AHI CC1G_15433_Ccin YRAPEVIFQM-GWDEKVDIWSIGVMLWDLIEN-KNL-FKTT--GGPDNKDGNNYHV-AHM CC1G_02719_Ccin LRAPELVLRS-SWGAPVDIWALGCMFFDLIFS-NRPPFDLR---G-PPGDLDAIHL-ARM CC1G_05630_Ccin CTPPEVRFDQ-TISFASDVWMLACTLFEIRAG-FSL-FDS--------FLRSENLVWRQA CC1G_06188_Ccin LRAPEVVLGH-EWNEKIDIWSLGCL----------------------------------- CC1G_13566_Ccin GFAPETLLSTPSCSPKTDIWMLGVMLFNLLTG-RAL-LTA-T--GT-AAE----RL-AEM CC1G_09673_Ccin ASAPETLLSNATCSSQTDIWMLGVMIFKLLTG-RDL-FTS-T--GT-PLE----RF-TEI CC1G_10260_Ccin YRAPEAIVGRKDWDTRADVWSVACVVFELLTA-EYL-FDPQG-QG-ELFTKDDDHM-AQI CC1G_04899_Ccin YRCPEVILGA-KWGTSADIWSVACVLFELITGGDYL-FDPA--SG-SRYSKDDDHI-AQI AqueK134_Aque YRSLEVIIGI-EYGPPADIWSLACMTFELLTG-DFL-FEPH--SG-DTYSRDEDHI-AHI SRPK_b_Smoe YRCPEVLVGS-KYSTPADMWSLACVVFELATG-DVL-FDPH--TG-EDYDRDEDHL-ALT SRPK_d_Smoe YRSPEVLLGC-KYSTPVDIWSFACLVFELATG-DVL-FDPH--SG-DQFDKDEDHL-ALM SRPK_a_Smoe YRSPEVLLGC-KYSTPVDIWSFACLVFELATG-DVL-FDPH--SG-DQFDKDEDHL-ALM SRPK_c_Smoe YRCPEVLVGS-KYSTPADMWSLACVVFELATG-DVL-FDPH--TG-EDYDRDEDHL-ALT GK042_Glam YRAPEVILGL-PFDEKADVWSVGCVIYEFLTG-HIL-FPTVDMSS-GKHISDAQHM-C-- * . *:: . SRPK2_Hsap IELLG-SIPR---HFAL-SGKY-SRE--FFNRR-G------------------------- SRPK1_Hsap IELLG-KVPR---KLIV-AGKY-SKE--FFTKK-G------------------------- MSSK1_Hsap VELLG-DIPP---AFAL-SGRY-SRE--FFNRR-G------------------------- MSSK1_Mmus VELLG-DIPP---AFAL-SGRY-SRE--FFNRR-G------------------------- SKY1_Scer IELLG-ELPS---YLLR-NGKY-TRT--FFNSR-G------------------------- CG8565_Dmel VETCG-RIPW---YLIR-KGKH-SRN--FINSA-G------------------------- SRPK_Dmel IELLG-PIPR---EILL-NGTY-AAK--SFTRS-C------------------------- SRPK1_Mmus IELLG-KVPR---KLIV-AGKY-SKE--FFTKK-G------------------------- SRPK2_Mmus IELLG-SIPR---HFAL-SGKY-SRE--FFNRR-G------------------------- spk-1_Cele SELLG-AIPP---SIYK-KGKH-WRE--FFHKN-G------------------------- Sky1_Ddis IELLG-KPPR---FIFA-GGDE-SRV--YFTHK-G------------------------- 13234_Tthe QESLG-KFNK---QFAL-SGTK-SRE--FFNKS-G------------------------- 22244_Tthe QELCN-KFTK---KFAL-SGFK-SKK--YFDKQ-G------------------------- 3884_Tthe EELCK-KFPK---SFAK-RGEK-SKK--YFDNN-G------------------------- SRPK_Spur IELVG-HIPK---HVAL-SGKY-SRD--FFNKK-G------------------------- CG11489_Dmel VELLG-SIPQ---SVIF-RGKH-GLK--YFTSY-G------------------------- CC1G_15433_Ccin IALLG-PPPK---DFLE-RTKE-TRLWNWFDKD-T---------ASWSSPDIVLSIFFS- CC1G_02719_Ccin EELLG-PFPP---SMRTLCREDTRDK--YFDDD-G------------------------- CC1G_05630_Ccin VEMLG-KLPD---PWWN-QWDA-RKV--WFAESDGEPKPEEVQKE-------------EG CC1G_06188_Ccin -EGLC-SEPK---EVLI-GGQ-RTI----------------------------------- CC1G_13566_Ccin CEVLEVQIPE---SWLH--DKN-LK-----D----------------------------- CC1G_09673_Ccin RHILEE------------------------------------------------------ CC1G_10260_Ccin IELLG-DFPL---DVKM-GGKY-SRE--LFDHT-G------------------------- CC1G_04899_Ccin MELLG-ELPR---SIAF-SGKY-SSE--FFNRK-G------------------------- AqueK134_Aque CELLG-TIPP---TLAV-SGRY-SRE--FFSHS-G------------------------- SRPK_b_Smoe MELLG-RMPR---KVAL-GGRY-SHD--YFNRH-G------------------------- SRPK_d_Smoe IELLG-RMPR---KVSL-GGRF-SRE--FFNRQ-G------------------------- SRPK_a_Smoe IELLG-RMPR---KVSL-GGRF-SRE--FFNRQ-G------------------------- SRPK_c_Smoe MELLG-RMPR---KVAL-GGRY-SHD--YFNRH-G------------------------- GK042_Glam -DILA-TVPFPGTEYFQ-ASP-LGLS--LLEDE-C------------------------- SRPK2_Hsap ------------------ELRHITKLK---PWSLFDVLV-EKYGWPHEDAAQFTDFLIPM SRPK1_Hsap ------------------DLKHITKLK---PWGLFEVLV-EKYEWSQEEAAGFTDFLLPM MSSK1_Hsap ------------------ELRHIHNLK---HWGLYEVLM-EKYEWPLEQATQFSAFLLPM MSSK1_Mmus ------------------ELRHIPNLK---HWGLYEVLM-EKYEWPLEQATQFSAFLLPM SKY1_Scer ------------------LLRNISKLK---FWPLEDVLT-EKYKFSKDEAKEISDFLSPM CG8565_Dmel ------------------KLCNIETLK---PLKLANILI-RWYGWRTRQSTEFVNFLMPM SRPK_Dmel ------------------ELRNISGLK---PWGLMDVLL-EKYEWSQKDAASFASFLTPM SRPK1_Mmus ------------------DLKHITKLK---PWGLLEVLV-EKYEWPQEEAAGFTDFLLPM SRPK2_Mmus ------------------ELRHITKLK---PWSLFDVLV-EKYGWPHEDAAQFTDFLIPM spk-1_Cele ------------------HLLHIHQLK---PWSLYEVLR-QKYEWSHEDAQQFESFLRPM Sky1_Ddis ------------------DLRKIPDLS--DQWPLFSVLT-EKYKFSIQEAKDFEAFLLPM 13234_Tthe ------------------QLIRIKEIQ---DYPISRILI-SEYDWDTKEALDIEDFLLPM 22244_Tthe ------------------NLRRIPSLH---YWPLLNVLI-EKYHFKEEEAKLFDEFMQVM 3884_Tthe ------------------NLRRIPQLQ---YWPLKSVLV-EKYRLKEKEAKAFEDFMMPM SRPK_Spur ------------------ELRNISKLK---PWSLYHVLT-EKYEWPKEDAEEFASFLYPM CG11489_Dmel ------------------SLRNITKLK---PWSLMNVLV-EKYDWDPVEAKKFSDFLLPM CC1G_15433_Ccin -----------------GAWKDEAEI---PAQTLENTI----TRMEGEEKALFINFARRI CC1G_02719_Ccin ------------------SLKFKIECSMAASGNLEQQLSPLRQTFSDHDVDELIRFMRRC CC1G_05630_Ccin VLLVARKCTIRDKLELIGKKEEPPRGK---DWPMTE--P-DETVMEEEEIKLLQDLLQKM CC1G_06188_Ccin --------------------CSQ------------------------------------- CC1G_13566_Ccin ---------------CSPEKRGLQI---------LEGHL--EAVLPQDQAKSVSSLLKSC CC1G_09673_Ccin -----------------------------------------------D------------ CC1G_10260_Ccin ------------------ALRYIRTLK---PWPLKRVMI-EKYLYSEEDSDALCAFLEPM CC1G_04899_Ccin ------------------ELRHINKLR---YWPLDSVLH-DKYLFPKHEADALAAFLLPM AqueK134_Aque ------------------KLKRIHHLR---PWSLHDVLV-DKYHWCDDEAKLLASFLLPM SRPK_b_Smoe ------------------DLRHIRKLR---FWPLKRVLV-EKYDFSEVDAQDLSSFLCPI SRPK_d_Smoe ------------------DLRHIKKLR---YWPLDKVLH-DKYSFPAQDAQELAEFLCPL SRPK_a_Smoe ------------------DLRHIKKLR---YWPLDKVLH-DKYSFPAQDAQELAEFLCPL SRPK_c_Smoe ------------------DLRHIRKLR---FWPLKRVLV-EKYDFSEVDAQDLSSFLCPI GK042_Glam ------------------TKKYLDATA---HFSLQ-LRL-EQTGFTREEACLAGSFLEQL SRPK2_Hsap LEMVPEKRASAGECLRHPWLN--------------------------------------- SRPK1_Hsap LELIPEKRATAAECLRHPWLN--------------------------------------- MSSK1_Hsap MEYIPEKRASAADCLQHPWLN--------------------------------------- MSSK1_Mmus MEYIPEKRASAADCLQHPWLN--------------------------------------- SKY1_Scer LQLDPRKRADAGGLVNHPWLKDTLGMEE-IRVP--------------DRE---------- CG8565_Dmel LQTNPLSRISASKALESHYLCNIALPGIDIDSYYYY----------SVREIK-------- SRPK_Dmel LEFDPNKRATAAECLQHPWL---------------------------------------- SRPK1_Mmus LELMPEKRATAAECLRHPWLN--------------------------------------- SRPK2_Mmus LEMVPEKRASAGECLRHPWLN--------------------------------------- spk-1_Cele LDFDQEKRSTAKIALKHPFLLPFGGRAPKSDCPP-ELLSKMFPDGLIPEPFDGN-EHQEV Sky1_Ddis LNYLPEKRATAKDCLNHTWLKDVP------------------------------------ 13234_Tthe LHYNPSKRIQAREALQHPWLW--------------------------------------- 22244_Tthe LKTNPLDRASAHECLQTKWIHTKPNYL--FKYT--------------DQEFIRYQ-DKKK 3884_Tthe LHCMPEKRATAEQMLNHPWLKGPTTSYE-FKQT--------------EQEYQDYIKRKQK SRPK_Spur LEFDPTKRATAKESLSHPWLY--------------------------------------- CG11489_Dmel LEYNPVIRASAAECLQHPWLEQE------------------------------------- CC1G_15433_Ccin LKWKPEERCSAKELSEDPWIRS-------------------------------------- CC1G_02719_Ccin LTIDPASRPTADELLQDPWLSANSQ----------------------------------- CC1G_05630_Ccin LRYRPEERISMAEVIQHPWFNY-------------------------------------- CC1G_06188_Ccin -------------------I---------------------------------------- CC1G_13566_Ccin LRLDPATRISAADLVAHEWIRAVPFC---------------------------------- CC1G_09673_Ccin ------------------------------------------------------------ CC1G_10260_Ccin LKADMRERAHARDMLDHPWLDVSNE----------------------------------- CC1G_04899_Ccin LRLHPDRRAKASELIHHNWLEGTVVQGE-IDVIK-------------RAEAEE-AARKKA AqueK134_Aque LNYNQKERATAKECLDHPWLT--------------------------------------- SRPK_b_Smoe LEFVPEKRLTAAQALQHSWLNSGPLLVTPSPAII------------AEEEAKL-LSSEQT SRPK_d_Smoe LDFVADKRPTAGQCLLHPWVNPVPRTIST-PAAP------------ATPAAAP-VVAAEV SRPK_a_Smoe LDFVADKRPTAGQCLLHPWVIPVPRTIST-PVAP------------ATPAAAP-AVAAEV SRPK_c_Smoe LEFVPEKRLTAAQALQHSWLNSGPLLVTPSPAII------------AEEEAKL-LSSEQT GK042_Glam LTVDHKKRPSATQMLEHPWLSTHGPTDA-LT----------------------------- SRPK2_Hsap ------------------------------------------------------------ SRPK1_Hsap ------------------------------------------------------------ MSSK1_Hsap ------------------------------------------------------------ MSSK1_Mmus ------------------------------------------------------------ SKY1_Scer ---------------------------------------LYGS----GSD---------I CG8565_Dmel --DCTHTKSERN----------------SDEDSSSCSSI--------------------D SRPK_Dmel ------------------------------------------------------------ SRPK1_Mmus ------------------------------------------------------------ SRPK2_Mmus ------------------------------------------------------------ spk-1_Cele YRDEND----------SRSAS---ERSANSRS-------AG----GSDDD---------D Sky1_Ddis ------------------------------------------------------------ 13234_Tthe ------------------------------------------------------------ 22244_Tthe LLQ------QED----LNLQS---HEAEDSDNF---DGDLSENDISIDSD---------D 3884_Tthe LIDIAKLQGEEY--VDPNQEN---NELYDDDIY---D-----GDGEVS-----------S SRPK_Spur ------------------------------------------------------------ CG11489_Dmel ------------------------------------------------------------ CC1G_15433_Ccin ------------------------------------------------------------ CC1G_02719_Ccin ------------------------------------------------------------ CC1G_05630_Ccin ------------------------------------------------------------ CC1G_06188_Ccin ------------------------------------------------------------ CC1G_13566_Ccin ------------------------------------------------------------ CC1G_09673_Ccin ------------------------------------------------------------ CC1G_10260_Ccin ------------------------------------------------------------ CC1G_04899_Ccin KADQQRQASQKHKRDDSKLVQAGGMQLLDEDEADAMKPI-EAGAVVADGEAEGEQKDLKP AqueK134_Aque ------------------------------------------------------------ SRPK_b_Smoe LS--------------------------KSDDAAALAPP--------------------- SRPK_d_Smoe LV--------------------------AAPAAGVLDKK--------------------- SRPK_a_Smoe LV--------------------------AAPAAGVLDKK--------------------- SRPK_c_Smoe LS--------------------------KSDDAAALAPA--------------------- GK042_Glam ------------------------------------------------------------ SRPK2_Hsap ------------------------------------------------------------ SRPK1_Hsap ------------------------------------------------------------ MSSK1_Hsap ------------------------------------------------------------ MSSK1_Mmus ------------------------------------------------------------ SKY1_Scer P--------------------------------------------------GWFE----- CG8565_Dmel SSEFSSDE-------------------------------------VC-YEDDV------- SRPK_Dmel ------------------------------------------------------------ SRPK1_Mmus ------------------------------------------------------------ SRPK2_Mmus ------------------------------------------------------------ spk-1_Cele EEEF------NMNRPGPSGHFPIFC----------------------------------- Sky1_Ddis ------------------------------------------------------------ 13234_Tthe ------------------------------------------------------------ 22244_Tthe KSEFQDDKFFGKYTPQIDQNL--IDRSFTNL------------GYIG-FGDGIKLDELDQ 3884_Tthe LEEFENDDEFYGYKPDINIKL--VDRSFTNL------------GYIG-YGDGIDLEALDN SRPK_Spur ------------------------------------------------------------ CG11489_Dmel ------------------------------------------------------------ CC1G_15433_Ccin ------------------------------------------------------------ CC1G_02719_Ccin ------------------------------------------------------------ CC1G_05630_Ccin ------------------------------------------------------------ CC1G_06188_Ccin ------------------------------------------------------------ CC1G_13566_Ccin ------------------------------------------------------------ CC1G_09673_Ccin ------------------------------------------------------------ CC1G_10260_Ccin ------------------------------------------------------------ CC1G_04899_Ccin VQQLQLQHQPPVLNPPPIPHGASGLTRTAPANVAKQVSPPPAANNRQPSAG--------- AqueK134_Aque ------------------------------------------------------------ SRPK_b_Smoe ----------------PPSKLTSAKGILLSL------------SFLK-HSR--------- SRPK_d_Smoe ----------------RSESSEAMKKAEVAM------------GNIA-IAG--------- SRPK_a_Smoe ----------------RSESSEAMKKAEVAM------------GNIA-IAG--------- SRPK_c_Smoe ----------------PPSKLTSAKGILLPL------------SFLK-HSR--------- GK042_Glam ------------------------------------------------------------ SRPK2_Hsap ----------S SRPK1_Hsap ----------S MSSK1_Hsap ----------P MSSK1_Mmus ----------P SKY1_Scer ---EVRDHKRH CG8565_Dmel --NEEDIKKLY SRPK_Dmel ----------R SRPK1_Mmus ----------S SRPK2_Mmus ----------S spk-1_Cele ---SRVFTFMF Sky1_Ddis -------PFLN 13234_Tthe ---------QQ 22244_Tthe DPNWQFMNLKD 3884_Tthe GGN--WQFNNV SRPK_Spur ----------S CG11489_Dmel --------EFV CC1G_15433_Ccin --------RFP CC1G_02719_Ccin -----DHSSES CC1G_05630_Ccin ---------KD CC1G_06188_Ccin -----NSSCCH CC1G_13566_Ccin ------DCFEV CC1G_09673_Ccin ------DIPSG CC1G_10260_Ccin -----EEVTEW CC1G_04899_Ccin --KKTSKSGRS AqueK134_Aque ----------L SRPK_b_Smoe --GLKACNTTA SRPK_d_Smoe --VIADASPQD SRPK_a_Smoe --IIADASQQD SRPK_c_Smoe --GLKACNTTA GK042_Glam ---QPGGWGHS