CLUSTAL W (1.83) multiple sequence alignment TGFbR2_Hsap_STKR2 MGRGLLRGL---WPLH-IVL--WTRIASTI------------------------------ TGFbR1_Hsap_STKR1 MEAAVAAPR---PRLL-LLV--LAAAAAAA------------------------------ MISR2_Hsap_STKR2 MLGSLGL--------W-AL---LPTAVEAP------------------------------ MISR2_Mmus_STKR2 MLGTLGL--------W-TL---LPAAAQVS------------------------------ BMPR2_Mmus_STKR2 MTSSLHRPFRVPWLLW-AVL--LVSTTAAS------------------------------ BMPR1B_Mmus_STKR1 MLLRSSG-----KLN-------VGTK---------------------------------- BMPR1A_Mmus_STKR1 MTQLYTYIR---LLGA-CLF--IISHVQGQ-NL--------------------------- ALK7_Mmus_STKR1 MTPARGSAL-----SL-ALL--LVALAAD------------------------------- ALK4_Mmus_STKR1 MAESAGASS---FFPL-VVL--LLAGSGGS------------------------------ ALK2_Mmus_STKR1 MVDGVMILP---VL-M--MM--AFPSPSVE------------------------------ ALK1_Mmus_STKR1 MTLGSFRRG---LL-M-LSV--AFGLTRGD------------------------------ ACTR2B_Mmus_STKR2 MTAPWAA-----L-AL-LW----GSLCAGS------------------------------ ACTR2_Mmus_STKR2 MGAAAKLA----F-AV-FL----ISCSSGA------------------------------ daf-4_Cele_STKR2 MNQKGTVR----LKALV-LICLPLFLIATP------------------------------ daf-1_Cele_STKR1 MRIRHVVFC---L--L-ALV--YGAETSDD------------------------------ BMPR1A_Hsap_STKR1 MPQLYIYIR---LLGA-YLF--IISRVQGQ-NL--------------------------- BMPR1B_Hsap_STKR1 MLLRSAG-----KLN-------VGTK---------------------------------- BMPR2_Hsap_STKR2 MTSSLQRPWRVPWLPW-TIL--LVSTAAAS------------------------------ ALK7_Hsap_STKR1 MTRALCSAL-----RQ-ALL--LLAAAAE------------------------------- ALK4_Hsap_STKR1 MAESAGASS---FFPL-VVL--LLAGSGGS------------------------------ tkv_Dmel_STKR1 MGSEFSANV---QPDV-EAM--AAAALSGMEM---------------------------- put_Dmel_STKR2 MSKYDLLY----LTAQLTLVCCLIGI-HGS------------------------------ SAX_Dmel_STKR1 MESNIYLVF---LL-T--FL--LYNNARAE------------------------------ wit_Dmel_STKR2 MNWAIYL-------LL-ALI--SLGRATPV------------------------------ BABO_Dmel_STKR1 MLSALRLI------FL-GAL--LGASVCAS------------------------------ TGFBR1_Mmus_STKR1 MEAAAAAPR---RPQL-LIV--LVAAAT-------------------------------- TGFBR2_Mmus_STKR2 MGRGLLRGL---WPLH-IVL--WTRIASTI------------------------------ sma-6_Cele_STKR1 MNITFIFIL------I-FGF--FNTQKCSK------------------------------ ALK2_Hsap_STKR1 MVDGVMILP---VL-I--MI--ALPSPSME------------------------------ ALK1_Hsap_STKR1 MTLGSPRKG---LL-M-LLM--AL-VTQGD------------------------------ ACTR2B_Hsap_STKR2 MTAPWVA-----L-AL-LW----GSLCAGS------------------------------ ACTR2_Hsap_STKR2 MGAAAKLA----F-AV-FL----ISCSSGA------------------------------ TGFbR1_Spur_STKR1 MEIIG------------------------------------------------------- ALK2_Spur_STKR1 MRASQDVYV--------ADL--AHQV---------------------------------- BMPR1_Spur_STKR1 MSYTYMRYY---EVLA-T------------------------------------------ TGFbRII_Spur_STKR2 MAYDVETDE---NNVP-FVV--TVSLGVAS------------------------------ ACTR2_Spur_STKR2 MAGKDPLIR---LCELFLFLSIAVLLVEGA------------------------------ BMPR2_Spur_STKR2 MHSSEHGDYTGKVIS--VIT--I-EAEIAE------------------------------ AqueK680_Aque_STKR1 LPF------------I-TSE--ITSATHSHT----------------------------- AqueK681_Aque_STKR1 MIILILILF---L--L-SPL--IISGTTGV------------------------------ AqueK682_Aque_STKR1 MSH--------------------------------------------------------- AqueK683_Aque_STKR2 MAELRILVF---C--L-LAL--LLPVPS-------------------------------- AqueK684_Aque_STKR2 MCVYLKTSD---VF-I-KCF--STACPGGA-DICIELCPEGINKCHTVRRTNSYPVEMRC AqueK685_Aque_STKR2 MINVTLFI--------------DPPDEA-------------------------------- AqueK686_Aque_STKR2 MVAVLRVVL---CF-C--LL--STIVTA-------------------------------- : TGFbR2_Hsap_STKR2 ---------------------------------------------------PPH------ TGFbR1_Hsap_STKR1 ----------------------------------------------------A------- MISR2_Hsap_STKR2 ------------------------------------------------------------ MISR2_Mmus_STKR2 ------------------------------------------------------------ BMPR2_Mmus_STKR2 ------------------------------------------------------------ BMPR1B_Mmus_STKR1 ----------------------KE------------------------DGEST------- BMPR1A_Mmus_STKR1 -DSMLHGTGMKS----DLDQKKPE------------------------NGVTL------- ALK7_Mmus_STKR1 ------------------------------------------------------------ ALK4_Mmus_STKR1 ----------------------------------------------------G------- ALK2_Mmus_STKR1 ---------------------------------------------------DE------- ALK1_Mmus_STKR1 ---------------------------------------------------LA------- ACTR2B_Mmus_STKR2 ---------------------------------------------------GR------- ACTR2_Mmus_STKR2 ---------------------------------------------------IL------- daf-4_Cele_STKR2 ---------------------------------------------------VP------- daf-1_Cele_STKR1 ----------------DLDERT--------------------------N----------- BMPR1A_Hsap_STKR1 -DSMLHGTGMKS----DSDQKKSE------------------------NGVTL------- BMPR1B_Hsap_STKR1 ----------------------KE------------------------DGEST------- BMPR2_Hsap_STKR2 ------------------------------------------------------------ ALK7_Hsap_STKR1 ------------------------------------------------------------ ALK4_Hsap_STKR1 ----------------------------------------------------G------- tkv_Dmel_STKR1 ------GSGPGSEGYEDADN------------------------------EKS------- put_Dmel_STKR2 ---------------------------------------------------IL------- SAX_Dmel_STKR1 ---------------------------------------------------IS-D----- wit_Dmel_STKR2 ------------------------------------------------------------ BABO_Dmel_STKR1 ----------------------------------------------------PIEFVMDT TGFBR1_Mmus_STKR1 ------------------------------------------------------------ TGFBR2_Mmus_STKR2 ---------------------------------------------------PPH------ sma-6_Cele_STKR1 ----------------DYDHFDDEDLALSIPKNAIGVPKEFRQQVLKEMKLRN------- ALK2_Hsap_STKR1 ---------------------------------------------------DE------- ALK1_Hsap_STKR1 ---------------------------------------------------PV------- ACTR2B_Hsap_STKR2 ---------------------------------------------------GR------- ACTR2_Hsap_STKR2 ---------------------------------------------------IL------- TGFbR1_Spur_STKR1 ------------------------------------------------------------ ALK2_Spur_STKR1 ------------------------------------------------------------ BMPR1_Spur_STKR1 ------------------------------------------------------------ TGFbRII_Spur_STKR2 ---------------------------------------------------A-------- ACTR2_Spur_STKR2 ---------------------------------------------------SV------- BMPR2_Spur_STKR2 ------------------------------------------------------------ AqueK680_Aque_STKR1 ---------------------------------------------------RS------- AqueK681_Aque_STKR1 ------------------------------------------------------------ AqueK682_Aque_STKR1 ------------------------------------------------------------ AqueK683_Aque_STKR2 ------------------------------------------------------------ AqueK684_Aque_STKR2 TN----------------------------------TPSCS-----------Q----SSD AqueK685_Aque_STKR2 EN----------------------------------APSSF-----------H----VTD AqueK686_Aque_STKR2 ------------------------------------FQC-------------R----VNS TGFbR2_Hsap_STKR2 ------------------------------------------------------------ TGFbR1_Hsap_STKR1 ------------------------------------------------------------ MISR2_Hsap_STKR2 ------------------------------------------------------------ MISR2_Mmus_STKR2 ------------------------------------------------------------ BMPR2_Mmus_STKR2 ------------------------------------------------------------ BMPR1B_Mmus_STKR1 ------------------------------------------------------------ BMPR1A_Mmus_STKR1 ------------------------------------------------------------ ALK7_Mmus_STKR1 ------------------------------------------------------------ ALK4_Mmus_STKR1 ------------------------------------------------------------ ALK2_Mmus_STKR1 ------------------------------------------------------------ ALK1_Mmus_STKR1 ------------------------------------------------------------ ACTR2B_Mmus_STKR2 ------------------------------------------------------------ ACTR2_Mmus_STKR2 ------------------------------------------------------------ daf-4_Cele_STKR2 ------------------------------------------------------------ daf-1_Cele_STKR1 --------------------------------------------------IFI------- BMPR1A_Hsap_STKR1 ------------------------------------------------------------ BMPR1B_Hsap_STKR1 ------------------------------------------------------------ BMPR2_Hsap_STKR2 ------------------------------------------------------------ ALK7_Hsap_STKR1 ------------------------------------------------------------ ALK4_Hsap_STKR1 ------------------------------------------------------------ tkv_Dmel_STKR1 ------------------------------------------------------------ put_Dmel_STKR2 ------------------------------------------------------------ SAX_Dmel_STKR1 --------------------------------HLREDIPDLDMELSSASSAHL------- wit_Dmel_STKR2 ------------------------------------------------------------ BABO_Dmel_STKR1 SLNGSRSDPATATHPGKWPPTTKAPALRAPAGTAGHAYQSPSSSLAADNRSHDNNNASAV TGFBR1_Mmus_STKR1 ------------------------------------------------------------ TGFBR2_Mmus_STKR2 ------------------------------------------------------------ sma-6_Cele_STKR1 ------------------------------------------------------------ ALK2_Hsap_STKR1 ------------------------------------------------------------ ALK1_Hsap_STKR1 ------------------------------------------------------------ ACTR2B_Hsap_STKR2 ------------------------------------------------------------ ACTR2_Hsap_STKR2 ------------------------------------------------------------ TGFbR1_Spur_STKR1 ------------------------------------------------------------ ALK2_Spur_STKR1 ------------------------------------------------------------ BMPR1_Spur_STKR1 ------------------------------------------------------------ TGFbRII_Spur_STKR2 ------------------------------------------------------------ ACTR2_Spur_STKR2 ------------------------------------------------------------ BMPR2_Spur_STKR2 ------------------------------------------------------------ AqueK680_Aque_STKR1 ------------------------------------------------------------ AqueK681_Aque_STKR1 ------------------------------------------------------------ AqueK682_Aque_STKR1 ------------------------------------------------------------ AqueK683_Aque_STKR2 ------------------------------------------------------------ AqueK684_Aque_STKR2 CV--------------------------------FETLQNFHSLHYCCCT---------- AqueK685_Aque_STKR2 QI-------------------------------------------TSSIE---------- AqueK686_Aque_STKR2 CI-------------------------------------------RCSSS---------- TGFbR2_Hsap_STKR2 ------------------------------VQ--KSDVEMEAQKDEIICPSCNRTAHPLR TGFbR1_Hsap_STKR1 ------------------------------AL--L------------------------- MISR2_Hsap_STKR2 ------------------------------------------------------------ MISR2_Mmus_STKR2 ------------------------------------------------------------ BMPR2_Mmus_STKR2 ------------------------------------------------------------ BMPR1B_Mmus_STKR1 ------------------------------AP--T------------------------- BMPR1A_Mmus_STKR1 ------------------------------AP--E------------------------- ALK7_Mmus_STKR1 -------------------------------L--A------------------------- ALK4_Mmus_STKR1 ----------------------------------P------------------------- ALK2_Mmus_STKR1 ------------------------------KP--K------------------------- ALK1_Mmus_STKR1 ------------------------------KP--S------------------------- ACTR2B_Mmus_STKR2 ----------------------------------G------------------------- ACTR2_Mmus_STKR2 ----------------------------------G------------------------- daf-4_Cele_STKR2 -------------------------------VAVT------------------------- daf-1_Cele_STKR1 ------R----DKLIPA----LK--LAEV-TK--V------------------------- BMPR1A_Hsap_STKR1 ------------------------------AP--E------------------------- BMPR1B_Hsap_STKR1 ------------------------------AP--T------------------------- BMPR2_Hsap_STKR2 ------------------------------------------------------------ ALK7_Hsap_STKR1 -------------------------------L--S------------------------- ALK4_Hsap_STKR1 ----------------------------------P------------------------- tkv_Dmel_STKR1 ------------------------------KT--V------------------------- put_Dmel_STKR2 -------------------------------P--G------------------------- SAX_Dmel_STKR1 ------N----GKELPA-------------VP--Q------------------------- wit_Dmel_STKR2 ------------------------------------------------------------ BABO_Dmel_STKR1 SMLLPQDGDASGAVAPAVTPQLPIYIAQP-SA--K------------------------- TGFBR1_Mmus_STKR1 -------------------------------L--L------------------------- TGFBR2_Mmus_STKR2 ------------------------------VP--KSDVEMEAQKDASIHLSCNRTIHPLK sma-6_Cele_STKR1 ------------------------------RP--N------------------------- ALK2_Hsap_STKR1 ------------------------------KP--K------------------------- ALK1_Hsap_STKR1 ------------------------------KP--S------------------------- ACTR2B_Hsap_STKR2 ----------------------------------G------------------------- ACTR2_Hsap_STKR2 ----------------------------------G------------------------- TGFbR1_Spur_STKR1 ------------------------------------------------------------ ALK2_Spur_STKR1 ------------------------------N----------------------------- BMPR1_Spur_STKR1 ------------------------------------------------------------ TGFbRII_Spur_STKR2 ------------------------------F----------------------------- ACTR2_Spur_STKR2 -------------------------------N--L------------------------- BMPR2_Spur_STKR2 ------------------------------------------------------------ AqueK680_Aque_STKR1 ------------------------------LP--L------------------------- AqueK681_Aque_STKR1 ------------------------------------------------------------ AqueK682_Aque_STKR1 ------------------------------------------------------------ AqueK683_Aque_STKR2 ------------------------------------------------------------ AqueK684_Aque_STKR2 GDLCNRLDNYTDSVDPI----LNVTSAIPTVP--V------------------------- AqueK685_Aque_STKR2 ---------------PS----LS--MIPSTVP--A------------------------- AqueK686_Aque_STKR2 ---------------SP----V----DCTVTP--V------------------------- TGFbR2_Hsap_STKR2 HINNDMIVTDNNG----------------------------------------------- TGFbR1_Hsap_STKR1 -----------PG----------------------------------------------- MISR2_Hsap_STKR2 ------------P----------------------------------------------- MISR2_Mmus_STKR2 ------------P----------------------------------------------- BMPR2_Mmus_STKR2 ------------Q----------------------------------------------- BMPR1B_Mmus_STKR1 -----------PR----------------------------------------------- BMPR1A_Mmus_STKR1 -----------DT----------------------------------------------- ALK7_Mmus_STKR1 -----------A------------------------------------------------ ALK4_Mmus_STKR1 -----------RG----------------------------------------------- ALK2_Mmus_STKR1 -----------VN----------------------------------------------- ALK1_Mmus_STKR1 ------------------------------------------------------------ ACTR2B_Mmus_STKR2 ------------E----------------------------------------------- ACTR2_Mmus_STKR2 ------------R----------------------------------------------- daf-4_Cele_STKR2 ------------EDDRQDRIESEAAEKEWANTLVSKVAQSNGTGTIKVSAPAKPTLRRMD daf-1_Cele_STKR1 -----------NF----------------------------------------------- BMPR1A_Hsap_STKR1 -----------DT----------------------------------------------- BMPR1B_Hsap_STKR1 -----------PR----------------------------------------------- BMPR2_Hsap_STKR2 ------------Q----------------------------------------------- ALK7_Hsap_STKR1 -----------P------------------------------------------------ ALK4_Hsap_STKR1 -----------RG----------------------------------------------- tkv_Dmel_STKR1 -----------EN----------------------------------------------- put_Dmel_STKR2 ------------S----------------------------------------------- SAX_Dmel_STKR1 --------NSVQT----------------------------------------------- wit_Dmel_STKR2 ------------P----------------------------------------------- BABO_Dmel_STKR1 -----------KP----------------------------------------------- TGFBR1_Mmus_STKR1 -----------PG----------------------------------------------- TGFBR2_Mmus_STKR2 HFNSDVMASDNGG----------------------------------------------- sma-6_Cele_STKR1 ------------D----------------------------------------------- ALK2_Hsap_STKR1 -----------VN----------------------------------------------- ALK1_Hsap_STKR1 ------------R----------------------------------------------- ACTR2B_Hsap_STKR2 ------------E----------------------------------------------- ACTR2_Hsap_STKR2 ------------R----------------------------------------------- TGFbR1_Spur_STKR1 ------------------------------------------------------------ ALK2_Spur_STKR1 ------------N----------------------------------------------- BMPR1_Spur_STKR1 ------------------------------------------------------------ TGFbRII_Spur_STKR2 ------------------------------------------------------------ ACTR2_Spur_STKR2 ------------P----------------------------------------------- BMPR2_Spur_STKR2 ------------L----------------------------------------------- AqueK680_Aque_STKR1 -----------PP----------------------------------------------- AqueK681_Aque_STKR1 ------------------------------------------------------------ AqueK682_Aque_STKR1 ------------------------------------------------------------ AqueK683_Aque_STKR2 ------------------------------------------------------------ AqueK684_Aque_STKR2 -----------P---------------------------------------VRP------ AqueK685_Aque_STKR2 -----------P------------------------------------------------ AqueK686_Aque_STKR2 -----------D------------------------------------------------ TGFbR2_Hsap_STKR2 -----AVKFPQLCKFCD------VRFS-TC---DNQK-S-----------C--MS-NCSI TGFbR1_Hsap_STKR1 -----ATA--LQCF-CH------L-----C---T------------------------KD MISR2_Hsap_STKR2 -----N-R--RTCVF-F-------EAP-GV---RG--STKTLGELL----DT--GTELPR MISR2_Mmus_STKR2 -----N-R--RTCVF-F-------EAP-GV---RG--STKTLGEMV----DA--GPGPPK BMPR2_Mmus_STKR2 -----NQE--RLCAF-K-------D-P-YQ---QD----LGIGESR--------ISHENG BMPR1B_Mmus_STKR1 -----PKI--LRCK-CH------H----HC---PED----------------------SV BMPR1A_Mmus_STKR1 -----LPF--LKCY-CS------G----HC---PDD----------------------AI ALK7_Mmus_STKR1 -------G--LKCV-CL------L-----C---D------------------------SS ALK4_Mmus_STKR1 -----IQA--LLCA-CT------S-----C---L------------------------QT ALK2_Mmus_STKR1 -----QKL--YMCV-CE------G--L-SC---GN------------------------- ALK1_Mmus_STKR1 ------KL--VNCT-CE------S--P-HC---KR------------------------- ACTR2B_Mmus_STKR2 -----AET--RECIY-Y-------N-A-NW---ELER-T---------N----Q----SG ACTR2_Mmus_STKR2 -----SET--QECLF-F-------N-A-NW---ERDR-T---------N----Q----TG daf-4_Cele_STKR2 NEEDEVIS--IECVY-Y-------DEM-EC---EKSG-D-----------C--E----IT daf-1_Cele_STKR1 -----TRL--HLCH-CS------R--EVGC---NART-TGWVPGIEFLNETDRS----FY BMPR1A_Hsap_STKR1 -----LPF--LKCY-CS------G----HC---PDD----------------------AI BMPR1B_Hsap_STKR1 -----PKV--LRCK-CH------H----HC---PED----------------------SV BMPR2_Hsap_STKR2 -----NQE--RLCAF-K-------D-P-YQ---QD----LGIGESR--------ISHENG ALK7_Hsap_STKR1 -------G--LKCV-CL------L-----C---D------------------------SS ALK4_Hsap_STKR1 -----VQA--LLCA-CT------S-----C---L------------------------QA tkv_Dmel_STKR1 -----ARS--LTCY-CD------G----SC---PDN----------------------VS put_Dmel_STKR2 -----HGI--IECEH-F-------DEK-MC---NTTQ-Q-----------C--E----TR SAX_Dmel_STKR1 -----HPR--YKCYSCE------P----PC---RDP-----------------Y----EF wit_Dmel_STKR2 -----NRQ--YSCMS-Y-------QED-DNSFHDDDGDQDSSGELQEQQVESTPIPSEPH BABO_Dmel_STKR1 -----ENK--IKCH-CD------T-----C---K------------------------ES TGFBR1_Mmus_STKR1 -----AKA--LQCF-CH------L-----C---T------------------------KD TGFBR2_Mmus_STKR2 -----AVKLPQLCKFCD------VRLS-TC---DNQK-S-----------C--MS-NCSI sma-6_Cele_STKR1 -----ILK--NRCY-CN------YDQS-IC----------------------------GN ALK2_Hsap_STKR1 -----PKL--YMCV-CE------G--L-SC---GN------------------------- ALK1_Hsap_STKR1 -----GPL--VTCT-CE------S--P-HC---KG------------------------- ACTR2B_Hsap_STKR2 -----AET--RECIY-Y-------N-A-NW---ELER-T---------N----Q----SG ACTR2_Hsap_STKR2 -----SET--QECLF-F-------N-A-NW---EKDR-T---------N----Q----TG TGFbR1_Spur_STKR1 ------------------------------------------------------------ ALK2_Spur_STKR1 -----SVT--LQCN-CD------D--Y-SC---EG------------------------- BMPR1_Spur_STKR1 ------KM--LYCY-CD------E----HC---PEI----------------------TR TGFbRII_Spur_STKR2 -----------ECLDCS------EVPV-EC---DAE--S-----------C--VPISCTT ACTR2_Spur_STKR2 -----LGS--THCHL-Y-------SSQ-EC---EKDG-T---------K-C--G----NT BMPR2_Spur_STKR2 -----YTE--TF------------------------------------------------ AqueK680_Aque_STKR1 -----LPN--NNIY-THPLTSAKT--P-SC---DIY----------------------AF AqueK681_Aque_STKR1 -----------QCF-ET------Q--D-GC---SL------------------------T AqueK682_Aque_STKR1 ------------------------------------------------------------ AqueK683_Aque_STKR2 ------YL--LVCY-TD------D--C-PY---DNNL-L-----------C--Y------ AqueK684_Aque_STKR2 -----SDV--LICER-Y-------NC--SF---NDDG-I-----------C--YHG--Y- AqueK685_Aque_STKR2 -----SNT--LRS-------------------------H-----------S--F----D- AqueK686_Aque_STKR2 -----QYS--YNY---------------YC---EAPS-H-----------C--T----P- TGFbR2_Hsap_STKR2 TSICE---K----PQEVCV-AVWRK------------N---D------------------ TGFbR1_Hsap_STKR1 NFTCV---T-----DGLCF-VSVTE------TT--------------------------- MISR2_Hsap_STKR2 AIRCL---Y-----SRCCF-GIWNL------TQD-------------------------- MISR2_Mmus_STKR2 GIRCL---Y-----SHCCF-GIWNL------THG-------------------------- BMPR2_Mmus_STKR2 TILCS---K-----GSTCY-GLWEK------SKG-------------------------- BMPR1B_Mmus_STKR1 NNICS---T-----DGYCF-TMIEE------DDS-------------------------- BMPR1A_Mmus_STKR1 NNTCI---T-----NGHCF-AIIEE------DDQ-------------------------- ALK7_Mmus_STKR1 NFTCQ---T-----EGACW-ASVML------TN--------------------------- ALK4_Mmus_STKR1 NYTCE---T-----DGACM-VSIFN------LD--------------------------- ALK2_Mmus_STKR1 EDHCE---G------QQCF-SSLSI------NDG-------------------------- ALK1_Mmus_STKR1 -PFCQ---G------SWCT-VVLVR------EQG-------------------------- ACTR2B_Mmus_STKR2 LERCE---GEQD-KRLHCY-ASWRN------S---------S------------------ ACTR2_Mmus_STKR2 VEPCY---GDKD-KRRHCF-ATWKN------I---------S------------------ daf-4_Cele_STKR2 KKTCY---SEAHLKAVGCL-AVFGL------PT---QE--INSTEP-------------- daf-1_Cele_STKR1 ENTCY---T-----DGSCY-QSAR------------------------------------ BMPR1A_Hsap_STKR1 NNTCI---T-----NGHCF-AIIEE------DDQ-------------------------- BMPR1B_Hsap_STKR1 NNICS---T-----DGYCF-TMIEE------DDS-------------------------- BMPR2_Hsap_STKR2 TILCS---K-----GSTCY-GLWEK------SKG-------------------------- ALK7_Hsap_STKR1 NFTCQ---T-----EGACW-ASVML------TN--------------------------- ALK4_Hsap_STKR1 NYTCE---T-----DGACM-VSIFN------LD--------------------------- tkv_Dmel_STKR1 NGTCE---T--R-PGGSCF-SAVQQ------LYD--ET---T------------------ put_Dmel_STKR2 IEHCK---MEAD-KFPSCY-VLWSV-------N---ET---T------------------ SAX_Dmel_STKR1 THTCQ---N-----AIQCW-KSRTR------DAD-------------------------- wit_Dmel_STKR2 RRTCP---D----GYTFCF-TIWNQ------TAN-------------------------- BABO_Dmel_STKR1 NNICE---T-----DGFCF-TSVEK------NSD-------------------------- TGFBR1_Mmus_STKR1 NFTCE---T-----DGLCF-VSVTE------TT--------------------------- TGFBR2_Mmus_STKR2 TAICE---K----PHEVCV-AVWRK------------N---D------------------ sma-6_Cele_STKR1 NMTCV---K--Q-DGAACY-HAVEE------VYN--KA---E------------------ ALK2_Hsap_STKR1 EDHCE---G------QQCF-SSLSI------NDG-------------------------- ALK1_Hsap_STKR1 -PTCR---G------AWCT-VVLVR------EEG-------------------------- ACTR2B_Hsap_STKR2 LERCE---GEQD-KRLHCY-ASWRN------S---------S------------------ ACTR2_Hsap_STKR2 VEPCY---GDKD-KRRHCF-ATWKN------I---------S------------------ TGFbR1_Spur_STKR1 ------------------------------------------------------------ ALK2_Spur_STKR1 TNRCE---A-----LRKCF-SSITE------VDG-------------------------- BMPR1_Spur_STKR1 NNTCY---P--S-PGGWCF-AQIQA------GED-------------------------- TGFbRII_Spur_STKR2 SVPCV----------GYCLIATFPDMTSSSMTNGSDPS---S------------------ ACTR2_Spur_STKR2 TEECD---NKEA-EIPSCY-VLWKN------ET---SS---G------------------ BMPR2_Spur_STKR2 ----------------------INI------SRL-------------------------- AqueK680_Aque_STKR1 LHTCI---S-----AIERW-TSRGR------SAD-------------------------- AqueK681_Aque_STKR1 AGVCN---A------STCY-MRILA------KAN--PR---N------------------ AqueK682_Aque_STKR1 ------------------------------------------------------------ AqueK683_Aque_STKR2 -KTCT---P----SSNSCV-RIAAI------DRS---N-FPP------------------ AqueK684_Aque_STKR2 -EVCPETFSSNP-DDHSCI-ATYHK------NP---TTNLIELMYKGCRHNRLPNPLTLQ AqueK685_Aque_STKR2 -ES-T---GTI------------------------------RSV-TGFTTS--------- AqueK686_Aque_STKR2 -QNVP---GSNR-DGYYCY-ASLFI------RN---LN---STDFDGHWFS--------- TGFbR2_Hsap_STKR2 ------------------------------------------------------------ TGFbR1_Hsap_STKR1 ------------------------------------------------------------ MISR2_Hsap_STKR2 ------------------------------------------------------------ MISR2_Mmus_STKR2 ------------------------------------------------------------ BMPR2_Mmus_STKR2 ------------------------------------------------------------ BMPR1B_Mmus_STKR1 ------------------------------------------------------------ BMPR1A_Mmus_STKR1 ------------------------------------------------------------ ALK7_Mmus_STKR1 ------------------------------------------------------------ ALK4_Mmus_STKR1 ------------------------------------------------------------ ALK2_Mmus_STKR1 ------------------------------------------------------------ ALK1_Mmus_STKR1 ------------------------------------------------------------ ACTR2B_Mmus_STKR2 ------------------------------------------------------------ ACTR2_Mmus_STKR2 ------------------------------------------------------------ daf-4_Cele_STKR2 ------------------------------------------------------------ daf-1_Cele_STKR1 ------------------------------------------------------------ BMPR1A_Hsap_STKR1 ------------------------------------------------------------ BMPR1B_Hsap_STKR1 ------------------------------------------------------------ BMPR2_Hsap_STKR2 ------------------------------------------------------------ ALK7_Hsap_STKR1 ------------------------------------------------------------ ALK4_Hsap_STKR1 ------------------------------------------------------------ tkv_Dmel_STKR1 ------------------------------------------------------------ put_Dmel_STKR2 ------------------------------------------------------------ SAX_Dmel_STKR1 ------------------------------------------------------------ wit_Dmel_STKR2 ------------------------------------------------------------ BABO_Dmel_STKR1 ------------------------------------------------------------ TGFBR1_Mmus_STKR1 ------------------------------------------------------------ TGFBR2_Mmus_STKR2 ------------------------------------------------------------ sma-6_Cele_STKR1 ------------------------------------------------------------ ALK2_Hsap_STKR1 ------------------------------------------------------------ ALK1_Hsap_STKR1 ------------------------------------------------------------ ACTR2B_Hsap_STKR2 ------------------------------------------------------------ ACTR2_Hsap_STKR2 ------------------------------------------------------------ TGFbR1_Spur_STKR1 ------------------------------------------------------------ ALK2_Spur_STKR1 ------------------------------------------------------------ BMPR1_Spur_STKR1 ------------------------------------------------------------ TGFbRII_Spur_STKR2 ------------------------------------------------------------ ACTR2_Spur_STKR2 ------------------------------------------------------------ BMPR2_Spur_STKR2 ------------------------------------------------------------ AqueK680_Aque_STKR1 ------------------------------------------------------------ AqueK681_Aque_STKR1 ------------------------------------------------------------ AqueK682_Aque_STKR1 ------------------------------------------------------------ AqueK683_Aque_STKR2 ------------------------------------------------------------ AqueK684_Aque_STKR2 ACSNSTSMCHIDNPLVSDQDSAVYYCCCGESLCNQNITFTHPTQVSTYDIDECAINNGGC AqueK685_Aque_STKR2 ------------------------------------------------------------ AqueK686_Aque_STKR2 ------------------------------------------------------------ TGFbR2_Hsap_STKR2 ------------------------------------------------------------ TGFbR1_Hsap_STKR1 ------------------------------------------------------------ MISR2_Hsap_STKR2 ------------------------------------------------------------ MISR2_Mmus_STKR2 ------------------------------------------------------------ BMPR2_Mmus_STKR2 ------------------------------------------------------------ BMPR1B_Mmus_STKR1 ------------------------------------------------------------ BMPR1A_Mmus_STKR1 ------------------------------------------------------------ ALK7_Mmus_STKR1 ------------------------------------------------------------ ALK4_Mmus_STKR1 ------------------------------------------------------------ ALK2_Mmus_STKR1 ------------------------------------------------------------ ALK1_Mmus_STKR1 ------------------------------------------------------------ ACTR2B_Mmus_STKR2 ------------------------------------------------------------ ACTR2_Mmus_STKR2 ------------------------------------------------------------ daf-4_Cele_STKR2 -----------------------------------------------YLKV--------- daf-1_Cele_STKR1 ------------------------------------------------------------ BMPR1A_Hsap_STKR1 ------------------------------------------------------------ BMPR1B_Hsap_STKR1 ------------------------------------------------------------ BMPR2_Hsap_STKR2 ------------------------------------------------------------ ALK7_Hsap_STKR1 ------------------------------------------------------------ ALK4_Hsap_STKR1 ------------------------------------------------------------ tkv_Dmel_STKR1 ------------------------------------------------------------ put_Dmel_STKR2 ------------------------------------------------------------ SAX_Dmel_STKR1 ------------------------------------------------------------ wit_Dmel_STKR2 ------------------------------------------------------------ BABO_Dmel_STKR1 ------------------------------------------------------------ TGFBR1_Mmus_STKR1 ------------------------------------------------------------ TGFBR2_Mmus_STKR2 ------------------------------------------------------------ sma-6_Cele_STKR1 ------------------------------------------------------------ ALK2_Hsap_STKR1 ------------------------------------------------------------ ALK1_Hsap_STKR1 ------------------------------------------------------------ ACTR2B_Hsap_STKR2 ------------------------------------------------------------ ACTR2_Hsap_STKR2 ------------------------------------------------------------ TGFbR1_Spur_STKR1 ------------------------------------------------------------ ALK2_Spur_STKR1 ------------------------------------------------------------ BMPR1_Spur_STKR1 ------------------------------------------------------------ TGFbRII_Spur_STKR2 ------------------------------------------------------------ ACTR2_Spur_STKR2 ------------------------------------------------------------ BMPR2_Spur_STKR2 ------------------------------------------------------------ AqueK680_Aque_STKR1 ------------------------------------------------------------ AqueK681_Aque_STKR1 ------------------------------------------------------------ AqueK682_Aque_STKR1 ------------------------------------------------------------ AqueK683_Aque_STKR2 ------------------------------------------------------------ AqueK684_Aque_STKR2 SETCINTPGNYSCECNAGRYLSPHSGRCEDNDGIICLYRNCTLDGSCHTNTTEHCASSHL AqueK685_Aque_STKR2 -----------------------------------------------LTSI--------- AqueK686_Aque_STKR2 -----------------------------------------------FFQV--------- TGFbR2_Hsap_STKR2 ----------------------EN---IT-LETVCHDPKL-PYHDFILEDAASPKCIMK- TGFbR1_Hsap_STKR1 ----------------------DK----VIHNSMCIAEID-L-----IPRDRPFVCAPS- MISR2_Hsap_STKR2 -----------------------R---AQVEMQGCRDSD--------EPGCESLHCDPS- MISR2_Mmus_STKR2 -----------------------R---AQVEMQGCRDSD--------EPGCESLHCDPV- BMPR2_Mmus_STKR2 -----------------------D---INLVKQGCWSHIGD------PQECHYEECVVT- BMPR1B_Mmus_STKR1 ----------------------GM----PVVTSGCLGLE-----------GSDFQCRDT- BMPR1A_Mmus_STKR1 ----------------------GE----TTLTSGCMKYE-----------GSDFQCKDS- ALK7_Mmus_STKR1 ----------------------GK----EQVIKSCVSLPE-L--------NAQVFCHSS- ALK4_Mmus_STKR1 ----------------------GV----EHHVRTCIPKVE-L-----VPAGKPFYCLSS- ALK2_Mmus_STKR1 -----------------------F----HVYQKGCFQVYE----------QGKMTCKT-- ALK1_Mmus_STKR1 ----------------------RH----PQVYRGCGSLN-------------QELCLG-- ACTR2B_Mmus_STKR2 ----------------------GT---IELVKKGCWLDD--------FNCYDRQECVAT- ACTR2_Mmus_STKR2 ----------------------GS---IEIVKQGCWLDD--------INCYDRTDCIEK- daf-4_Cele_STKR2 ----------------------DK---PQYKSLGCMPYQH-ADS---MNCENESSCRQG- daf-1_Cele_STKR1 -------------------------PSPEISHFGCMDEKS-VTDETEFHDTAAKVCTNN- BMPR1A_Hsap_STKR1 ----------------------GE----TTLASGCMKYE-----------GSDFQCKDS- BMPR1B_Hsap_STKR1 ----------------------GL----PVVTSGCLGLE-----------GSDFQCRDT- BMPR2_Hsap_STKR2 -----------------------D---INLVKQGCWSHIGD------PQECHYEECVVT- ALK7_Hsap_STKR1 ----------------------GK----EQVIKSCVSLPE-L--------NAQVFCHSS- ALK4_Hsap_STKR1 ----------------------GM----EHHVRTCIPKVE-L-----VPAGKPFYCLSS- tkv_Dmel_STKR1 ----------------------GMY--EEERTYGCMPPED-N--------GGFLMCKVA- put_Dmel_STKR2 ----------------------GI---LRIKMKGCFTDM--------HEC-NQTECVTS- SAX_Dmel_STKR1 ----------------------GQ----VQESRGCSTSPD----------QLPMICSQNS wit_Dmel_STKR2 -----------------------G---ARVVKQGCWKDNTDR-----TSICSQSECTSS- BABO_Dmel_STKR1 ----------------------GS----IIFSYSCMVVKY-N-----MQRSKPFECLTS- TGFBR1_Mmus_STKR1 ----------------------DK----VIHNSMCIAEID-L-----IPRDRPFVCAPS- TGFBR2_Mmus_STKR2 ----------------------KN---IT-LETVCHDPKL-TYHGFTLEDAASPKCVMK- sma-6_Cele_STKR1 ----------------------KR--METLHKWGCATLER-G------SGASHLTCNSW- ALK2_Hsap_STKR1 -----------------------F----HVYQKGCFQVYE----------QGKMTCKT-- ALK1_Hsap_STKR1 ----------------------RH----PQEHRGCGNLH-------------RELCRG-- ACTR2B_Hsap_STKR2 ----------------------GT---IELVKKGCWLDD--------FNCYDRQECVAT- ACTR2_Hsap_STKR2 ----------------------GS---IEIVKQGCWLDD--------INCYDRTDCVEK- TGFbR1_Spur_STKR1 ------------------------------------------------------------ ALK2_Spur_STKR1 -----------------------I----IMKRMGCVNTEE----------QFNMFCKM-- BMPR1_Spur_STKR1 ----------------------GVEHETPIRSYGCLAPEE-D--------GGLMQCKGQ- TGFbRII_Spur_STKR2 ----------------------QN---IN-GMFACINETN-------PEIGGKKHCQAH- ACTR2_Spur_STKR2 ----------------------GG---VDVMMRGCWQNQ--------GDCLDMDYCMSS- BMPR2_Spur_STKR2 -----------------------H---QSLYIQGCWGNEAK------SLNCNQENCTAH- AqueK680_Aque_STKR1 ----------------------GY----SRRGRGCSTCKL-T-----VS--WSQQNKES- AqueK681_Aque_STKR1 -----------------------ISEHQFSYIYGCLPEEE-GGNGPS---VIASLCSGP- AqueK682_Aque_STKR1 ------------------------------------------------------------ AqueK683_Aque_STKR2 ----------------------AR---IIFQEFGCSSLRC-N--------TRDLLCSP-- AqueK684_Aque_STKR2 ISDDLRTETHLHYCVALFHFINGT---FYPNTQSCFAGS-----HSS--C-QNTNCTLT- AqueK685_Aque_STKR2 -----------------------------------E-HS-----SSR-----------I- AqueK686_Aque_STKR2 --------------------------------ESCEEAA-----GSE----LTDDCLSI- TGFbR2_Hsap_STKR2 ------EK------KKPGETFFMCSC-SSDECND-------------------------- TGFbR1_Hsap_STKR1 ------SKT--------GSVTTTYCC-NQDHCNK-------------------------- MISR2_Hsap_STKR2 ------PRAH----PSPGSTLFTCSC-GTDFCNA-------------------------- MISR2_Mmus_STKR2 ------PRAH----PNPSSTLFTCSC-GTDFCNA-------------------------- BMPR2_Mmus_STKR2 ------TTPP----SIQNGTYRFCCC-STDLCNV-------------------------- BMPR1B_Mmus_STKR1 ------PIP--------HQRRSIECCTERNECNK-------------------------- BMPR1A_Mmus_STKR1 ------PKA--------QLRRTIECC-RTNLCNQ-------------------------- ALK7_Mmus_STKR1 ------N-----------NVTKTECC-FTDFCNN-------------------------- ALK4_Mmus_STKR1 ------E-----------DLRNTHCC-YIDFCNK-------------------------- ALK2_Mmus_STKR1 -------P-------P-SPGQAVECC-QGDWCNR-------------------------- ALK1_Mmus_STKR1 -------R-------P-TEFLNHHCC-YRSFCNH-------------------------- ACTR2B_Mmus_STKR2 ------EE---------NPQVYFCCC-EGNFCNE-------------------------- ACTR2_Mmus_STKR2 ------KD---------SPEVYFCCC-EGNMCNE-------------------------- daf-4_Cele_STKR2 ------RS--------FRGGIGMCCC-STNNCNM-------------------------- daf-1_Cele_STKR1 ------TK------D-PHATVWICCD-KGNFCAN-------------------------- BMPR1A_Hsap_STKR1 ------PKA--------QLRRTIECC-RTNLCNQ-------------------------- BMPR1B_Hsap_STKR1 ------PIP--------HQRRSIECCTERNECNK-------------------------- BMPR2_Hsap_STKR2 ------TTPP----SIQNGTYRFCCC-STDLCNV-------------------------- ALK7_Hsap_STKR1 ------N-----------NVTKTECC-FTDFCNN-------------------------- ALK4_Hsap_STKR1 ------E-----------DLRNTHCC-YTDYCNR-------------------------- tkv_Dmel_STKR1 ------AVP-----H--LHGKNIVCCDKEDFCNR-------------------------- put_Dmel_STKR2 ------AE-------PRQGNIHFCCC-KGSRCNS-------------------------- SAX_Dmel_STKR1 LKINGPSKR-----NT-GKFVNVVCC-AGDYCNE-------------------------- wit_Dmel_STKR2 --------AP----TSKTSSLYYCCC-SGGVCNA-------------------------- BABO_Dmel_STKR1 ------NER--------FDTYRIDCC-KSDFCNK-------------------------- TGFBR1_Mmus_STKR1 ------SKT--------GAVTTTYCC-NQDHCNK-------------------------- TGFBR2_Mmus_STKR2 ------EK------KRAGETFFMCAC-NMEECND-------------------------- sma-6_Cele_STKR1 ------RAA-----H--HSPKSIGCCYEGNYCNK-------------------------- ALK2_Hsap_STKR1 -------P-------P-SPGQAVECC-QGDWCNR-------------------------- ALK1_Hsap_STKR1 -------R-------P-TEFVNHYCC-DSHLCNH-------------------------- ACTR2B_Hsap_STKR2 ------EE---------NPQVYFCCC-EGNFCNE-------------------------- ACTR2_Hsap_STKR2 ------KD---------SPEVYFCCC-EGNMCNE-------------------------- TGFbR1_Spur_STKR1 ------------------------------------------------------------ ALK2_Spur_STKR1 -------H-------P-YPDISVLCC-NRSFCNN-------------------------- BMPR1_Spur_STKR1 ------LSN-----H--RISRTVYCCNDEPNCNL-------------------------- TGFbRII_Spur_STKR2 ------PDDY----SYAAEGSYSCSC-ASDGCNK-------------------------- ACTR2_Spur_STKR2 ------SP--------ADQNLFFCCC-VGNLCNM-------------------------- BMPR2_Spur_STKR2 ------SKPSEYLVRTKNQTSRICCC-AGDYCNR-------------------------- AqueK680_Aque_STKR1 ------PSE-----QPVNKVMHFFCC-DDDYCNQ-------------------------- AqueK681_Aque_STKR1 ------ASW-----D-RELLISYTCC-TSDHCNK-------------------------- AqueK682_Aque_STKR1 ------------------------------------------------------------ AqueK683_Aque_STKR2 -------N-------I-TDLTQHCCC-TGDRCNNPGGRADALAELMKPKFSYHLSPPNEP AqueK684_Aque_STKR2 ---NIT-RL-----S-HNNDVYSCCC-YGDLCNE-------------------------- AqueK685_Aque_STKR2 ---ISS-IP-----Q-ST-NSLTSVS-TRSSTES-------------------------- AqueK686_Aque_STKR2 ---TKR-VS-----S-LEGTNIFCRC-TEDNCQD-------------------------- TGFbR2_Hsap_STKR2 ---------------------------------------------NIIFSE--------- TGFbR1_Hsap_STKR1 ---------------------------------------------IEL------------ MISR2_Hsap_STKR2 ---------------------------------------------NYSH-L--------- MISR2_Mmus_STKR2 ---------------------------------------------NYSH-L--------- BMPR2_Mmus_STKR2 ---------------------------------------------NFTENF--------- BMPR1B_Mmus_STKR1 ---------------------------------------------DLHPTL--------- BMPR1A_Mmus_STKR1 ---------------------------------------------YLQPTL--------- ALK7_Mmus_STKR1 ---------------------------------------------ITL-HL--------- ALK4_Mmus_STKR1 ---------------------------------------------IDL-RV--------- ALK2_Mmus_STKR1 ---------------------------------------------NITAQ---------- ALK1_Mmus_STKR1 ---------------------------------------------NVSLM---------- ACTR2B_Mmus_STKR2 ---------------------------------------------RFT-HL--------- ACTR2_Mmus_STKR2 ---------------------------------------------KFS-YF--------- daf-4_Cele_STKR2 ---------------------------------------------PDLIEM--------- daf-1_Cele_STKR1 ---------------------------------------------ETIIHL--------- BMPR1A_Hsap_STKR1 ---------------------------------------------YLQPTL--------- BMPR1B_Hsap_STKR1 ---------------------------------------------DLHPTL--------- BMPR2_Hsap_STKR2 ---------------------------------------------NFTENF--------- ALK7_Hsap_STKR1 ---------------------------------------------ITL-HL--------- ALK4_Hsap_STKR1 ---------------------------------------------IDL-RV--------- tkv_Dmel_STKR1 ---------------------------------------------DLYPTY--------- put_Dmel_STKR2 ---------------------------------------------NQK-YI--------- SAX_Dmel_STKR1 ---------------------------------------------GDFPEL--------- wit_Dmel_STKR2 ---------------------------------------------QYSV-VE-------- BABO_Dmel_STKR1 ---------------------------------------------NEI-MK--------- TGFBR1_Mmus_STKR1 ---------------------------------------------IEL------------ TGFBR2_Mmus_STKR2 ---------------------------------------------YIIFSE--------- sma-6_Cele_STKR1 ---------------------------------------------NLIPPA--------- ALK2_Hsap_STKR1 ---------------------------------------------NITAQ---------- ALK1_Hsap_STKR1 ---------------------------------------------NVSLV---------- ACTR2B_Hsap_STKR2 ---------------------------------------------RFT-HL--------- ACTR2_Hsap_STKR2 ---------------------------------------------KFS-YF--------- TGFbR1_Spur_STKR1 ------------------------------------------------------------ ALK2_Spur_STKR1 ---------------------------------------------DLQPTF--------- BMPR1_Spur_STKR1 ---------------------------------------------KLNPTL--------- TGFbRII_Spur_STKR2 ---------------------------------------------VLYTAE--------- ACTR2_Spur_STKR2 ---------------------------------------------NFS-FL--------- BMPR2_Spur_STKR2 ---------------------------------------------NVSDAYV-------- AqueK680_Aque_STKR1 ---------------------------------------------DIMHSI--------- AqueK681_Aque_STKR1 ---------------------------------------------NIEPRHDIESLLINR AqueK682_Aque_STKR1 ------------------------------------------------------------ AqueK683_Aque_STKR2 VPSTEPGCSVANTSDITPDCIIDVPFIGALKNEYTCYCNESLCNINESITH--------- AqueK684_Aque_STKR2 ---------------------------------------------RGLIF---------- AqueK685_Aque_STKR2 --------------------------------------------------V--------- AqueK686_Aque_STKR2 ---------------------------------------------IFNVTII-------- TGFbR2_Hsap_STKR2 -------------------EY--------------------------------------- TGFbR1_Hsap_STKR1 -------------------PT---------------------TVK--------------- MISR2_Hsap_STKR2 -------------------PP---------------------PGS--------------- MISR2_Mmus_STKR2 -------------------PP---------------------SGN--------------- BMPR2_Mmus_STKR2 -------------------PP---------------------PDT--------------- BMPR1B_Mmus_STKR1 -------------------PP---------------------LKD--------------- BMPR1A_Mmus_STKR1 -------------------PP---------------------VVI--------------- ALK7_Mmus_STKR1 -------------------PT---------------------ASP--------------- ALK4_Mmus_STKR1 -------------------PS---------------------GHL--------------- ALK2_Mmus_STKR1 -------------------LP---------------------TKG--------------- ALK1_Mmus_STKR1 -------------------LE---------------------ATQ--------------- ACTR2B_Mmus_STKR2 -------------------PE---------------------PGG--------------- ACTR2_Mmus_STKR2 -------------------PE---------------------MEV--------------- daf-4_Cele_STKR2 -------------------VN---------------------PSL--------------- daf-1_Cele_STKR1 ------------------------------------------------------------ BMPR1A_Hsap_STKR1 -------------------PP---------------------VVI--------------- BMPR1B_Hsap_STKR1 -------------------PP---------------------LKN--------------- BMPR2_Hsap_STKR2 -------------------PP---------------------PDT--------------- ALK7_Hsap_STKR1 -------------------PT---------------------ASP--------------- ALK4_Hsap_STKR1 -------------------PS---------------------GHL--------------- tkv_Dmel_STKR1 -------------------TP---------------------KLT--------------- put_Dmel_STKR2 -------------------KS---------------------TT---------------- SAX_Dmel_STKR1 -------------------LP---------------------FDS--------------- wit_Dmel_STKR2 -------------------PA---------------------PLE--------------- BABO_Dmel_STKR1 -------------------RI---------------------FE---------------- TGFBR1_Mmus_STKR1 -------------------PT---------------------TGP--------------- TGFBR2_Mmus_STKR2 -------------------EY--------------------------------------- sma-6_Cele_STKR1 -------------------YVHHHKEKALQ----------EKTDN--------------- ALK2_Hsap_STKR1 -------------------LP---------------------TKG--------------- ALK1_Hsap_STKR1 -------------------LE---------------------ATQ--------------- ACTR2B_Hsap_STKR2 -------------------PE---------------------AGG--------------- ACTR2_Hsap_STKR2 -------------------PE---------------------MEV--------------- TGFbR1_Spur_STKR1 ------------------------------------------------------------ ALK2_Spur_STKR1 -------------------LP---------------------TTT--------------- BMPR1_Spur_STKR1 -------------------PP---------------------TTT--------------- TGFbRII_Spur_STKR2 -------------------ATI--------------------PEE--------------- ACTR2_Spur_STKR2 -------------------PT---------------------PE---------------- BMPR2_Spur_STKR2 -------------------PL---------------------PST--------------- AqueK680_Aque_STKR1 -------------------LE---------------------SVS--------------- AqueK681_Aque_STKR1 YNNDSNDQESSSVFVSSSVPS---------------------SSSVPILPSVPILLSVPI AqueK682_Aque_STKR1 ------------------------------------------------------------ AqueK683_Aque_STKR2 -------------------PT---------------------RLS--------------- AqueK684_Aque_STKR2 -------------------PDFN-----------------A-TSP--I-P---------- AqueK685_Aque_STKR2 -----------------LVP---------------------------------------- AqueK686_Aque_STKR2 -----------------IDPPND------VSSSTLINGVIT-SSP--S-P---------- TGFbR2_Hsap_STKR2 ------------------------------------------------------------ TGFbR1_Hsap_STKR1 ------------------------------------------------------------ MISR2_Hsap_STKR2 ------------------------------------------------------------ MISR2_Mmus_STKR2 ------------------------------------------------------------ BMPR2_Mmus_STKR2 ------------------------------------------------------------ BMPR1B_Mmus_STKR1 ------------------------------------------------------------ BMPR1A_Mmus_STKR1 ------------------------------------------------------------ ALK7_Mmus_STKR1 ------------------------------------------------------------ ALK4_Mmus_STKR1 ------------------------------------------------------------ ALK2_Mmus_STKR1 ------------------------------------------------------------ ALK1_Mmus_STKR1 ------------------------------------------------------------ ACTR2B_Mmus_STKR2 ------------------------------------------------------------ ACTR2_Mmus_STKR2 ------------------------------------------------------------ daf-4_Cele_STKR2 ------------------------------------------------------------ daf-1_Cele_STKR1 ------------------------------------------------------------ BMPR1A_Hsap_STKR1 ------------------------------------------------------------ BMPR1B_Hsap_STKR1 ------------------------------------------------------------ BMPR2_Hsap_STKR2 ------------------------------------------------------------ ALK7_Hsap_STKR1 ------------------------------------------------------------ ALK4_Hsap_STKR1 ------------------------------------------------------------ tkv_Dmel_STKR1 ------------------------------------------------------------ put_Dmel_STKR2 ------------------------------------------------------------ SAX_Dmel_STKR1 ------------------------------------------------------------ wit_Dmel_STKR2 ------------------------------------------------------------ BABO_Dmel_STKR1 ------------------------------------------------------------ TGFBR1_Mmus_STKR1 ------------------------------------------------------------ TGFBR2_Mmus_STKR2 ------------------------------------------------------------ sma-6_Cele_STKR1 ------------------------------------------------------------ ALK2_Hsap_STKR1 ------------------------------------------------------------ ALK1_Hsap_STKR1 ------------------------------------------------------------ ACTR2B_Hsap_STKR2 ------------------------------------------------------------ ACTR2_Hsap_STKR2 ------------------------------------------------------------ TGFbR1_Spur_STKR1 ------------------------------------------------------------ ALK2_Spur_STKR1 ------------------------------------------------------------ BMPR1_Spur_STKR1 ------------------------------------------------------------ TGFbRII_Spur_STKR2 ------------------------------------------------------------ ACTR2_Spur_STKR2 ------------------------------------------------------------ BMPR2_Spur_STKR2 ------------------------------------------------------------ AqueK680_Aque_STKR1 ------------------------------------------------------------ AqueK681_Aque_STKR1 SPSVPISPSVPISF----------------SSSYQYLYDLTSLPTKDTSTFNNPSIIIYF AqueK682_Aque_STKR1 ------------------------------------------------------------ AqueK683_Aque_STKR2 ------------------------------------------------------------ AqueK684_Aque_STKR2 -MSS-------------------------------------------------------- AqueK685_Aque_STKR2 ------------------------------------------------------------ AqueK686_Aque_STKR2 -PSVY--SSVPLSLSLSSSTIDLTTSSVSFS----------------------------- TGFbR2_Hsap_STKR2 ------------------------------------NTS--------------------- TGFbR1_Hsap_STKR1 ------------------------------------------------------------ MISR2_Hsap_STKR2 -------------------------------------PGT-------------------- MISR2_Mmus_STKR2 -------------------------------------QGA-------------------- BMPR2_Mmus_STKR2 ------------------------------------TPLS-------------------- BMPR1B_Mmus_STKR1 ------------------------------------RD-F-------------------- BMPR1A_Mmus_STKR1 ------------------------------------GP-F-------------------- ALK7_Mmus_STKR1 ------------------------------------------------------------ ALK4_Mmus_STKR1 ------------------------------------KE-P-------------------- ALK2_Mmus_STKR1 ------------------------------------KS-F-------------------- ALK1_Mmus_STKR1 ------------------------------------TP-S-------------------- ACTR2B_Mmus_STKR2 ------------------------------------PE-V-------------------- ACTR2_Mmus_STKR2 ------------------------------------TQ-P-------------------- daf-4_Cele_STKR2 ------------------------------------KK-D-------------------- daf-1_Cele_STKR1 -------------------------------------A-P-------------------- BMPR1A_Hsap_STKR1 ------------------------------------GP-F-------------------- BMPR1B_Hsap_STKR1 ------------------------------------RD-F-------------------- BMPR2_Hsap_STKR2 ------------------------------------TPLS-------------------- ALK7_Hsap_STKR1 ------------------------------------------------------------ ALK4_Hsap_STKR1 ------------------------------------KE-P-------------------- tkv_Dmel_STKR1 ------------------------------------TP-A-------------------- put_Dmel_STKR2 ------------------------------------EA-T-------------------- SAX_Dmel_STKR1 ------------------------------------ND-V-------------------- wit_Dmel_STKR2 ------------------------------------LGSN-------------------- BABO_Dmel_STKR1 -------------------------------------T-D-------------------- TGFBR1_Mmus_STKR1 ----------------F-------------------SE-K-------------------- TGFBR2_Mmus_STKR2 ------------------------------------TTS--------------------- sma-6_Cele_STKR1 ------------------------------------PE-D-------------------- ALK2_Hsap_STKR1 ------------------------------------KS-F-------------------- ALK1_Hsap_STKR1 ------------------------------------PP-S-------------------- ACTR2B_Hsap_STKR2 ------------------------------------PE-V-------------------- ACTR2_Hsap_STKR2 ------------------------------------TQ-P-------------------- TGFbR1_Spur_STKR1 ------------------------------------------------------------ ALK2_Spur_STKR1 ------------------------------------PR-I-------------------- BMPR1_Spur_STKR1 ------------------------------------ST-T-------------------- TGFbRII_Spur_STKR2 ------------------------------------PTVP-------------------- ACTR2_Spur_STKR2 ------------------------------------PT-P-------------------- BMPR2_Spur_STKR2 ------------------------------------KPTV-------------------- AqueK680_Aque_STKR1 ------------------------------------AT---------------------- AqueK681_Aque_STKR1 SEPTNDPHLYDLTSLPTKDTSTFNNSSIIIY--F--SE-P-------------------- AqueK682_Aque_STKR1 ------------------------------------------------------------ AqueK683_Aque_STKR2 ------------------------------------SYGFKECLSYNCEYNCNIVNNTNI AqueK684_Aque_STKR2 ------TSLMA-------SSDS---ITIFLS---SSPY-V-------------------- AqueK685_Aque_STKR2 -------------------------------------S-S-------------------- AqueK686_Aque_STKR2 -I-NTSPTLIT------VTNTH---TTGILTTSSVVPS-S-------------------- TGFbR2_Hsap_STKR2 ------------------------------------------------------------ TGFbR1_Hsap_STKR1 ------------------------------------------------------------ MISR2_Hsap_STKR2 ------------------------------------------------------------ MISR2_Mmus_STKR2 ------------------------------------------------------------ BMPR2_Mmus_STKR2 ------------------------------------------------------------ BMPR1B_Mmus_STKR1 ------------------------------------------------------------ BMPR1A_Mmus_STKR1 ------------------------------------------------------------ ALK7_Mmus_STKR1 ------------------------------------------------------------ ALK4_Mmus_STKR1 ------------------------------------------------------------ ALK2_Mmus_STKR1 ------------------------------------------------------------ ALK1_Mmus_STKR1 ------------------------------------------------------------ ACTR2B_Mmus_STKR2 ------------------------------------------------------------ ACTR2_Mmus_STKR2 ------------------------------------------------------------ daf-4_Cele_STKR2 ------------------------------------------------------------ daf-1_Cele_STKR1 ------------------------------------------------------------ BMPR1A_Hsap_STKR1 ------------------------------------------------------------ BMPR1B_Hsap_STKR1 ------------------------------------------------------------ BMPR2_Hsap_STKR2 ------------------------------------------------------------ ALK7_Hsap_STKR1 ------------------------------------------------------------ ALK4_Hsap_STKR1 ------------------------------------------------------------ tkv_Dmel_STKR1 ------------------------------------------------------------ put_Dmel_STKR2 ------------------------------------------------------------ SAX_Dmel_STKR1 ------------------------------------------------------------ wit_Dmel_STKR2 ------------------------------------------------------------ BABO_Dmel_STKR1 ------------------------------------------------------------ TGFBR1_Mmus_STKR1 ------------------------------------------------------------ TGFBR2_Mmus_STKR2 ------------------------------------------------------------ sma-6_Cele_STKR1 ------------------------------------------------------------ ALK2_Hsap_STKR1 ------------------------------------------------------------ ALK1_Hsap_STKR1 ------------------------------------------------------------ ACTR2B_Hsap_STKR2 ------------------------------------------------------------ ACTR2_Hsap_STKR2 ------------------------------------------------------------ TGFbR1_Spur_STKR1 ------------------------------------------------------------ ALK2_Spur_STKR1 ------------------------------------------------------------ BMPR1_Spur_STKR1 ------------------------------------------------------------ TGFbRII_Spur_STKR2 ------------------------------------------------------------ ACTR2_Spur_STKR2 ------------------------------------------------------------ BMPR2_Spur_STKR2 ------------------------------------------------------------ AqueK680_Aque_STKR1 ------------------------------------------------------------ AqueK681_Aque_STKR1 ------------------------------------------------------------ AqueK682_Aque_STKR1 ------------------------------------------------------------ AqueK683_Aque_STKR2 NCSCPAGFIAIGFTRCRDVNECLVSNGGCQQTCVNTIGSYYCECFDGYFFDSRTLSCLSK AqueK684_Aque_STKR2 ------------------------------------------------------------ AqueK685_Aque_STKR2 ------------------------------------------------------------ AqueK686_Aque_STKR2 ------------------------------------------------------------ TGFbR2_Hsap_STKR2 ------------------------------------------------------------ TGFbR1_Hsap_STKR1 -------------------------------------------------------S---- MISR2_Hsap_STKR2 ------------------------------------------------------PG---- MISR2_Mmus_STKR2 ------------------------------------------------------PG---- BMPR2_Mmus_STKR2 ------------------------------------------------------P----- BMPR1B_Mmus_STKR1 ------------------------------------------------------V----- BMPR1A_Mmus_STKR1 ------------------------------------------------------F----- ALK7_Mmus_STKR1 -------------------------------------------------------N---- ALK4_Mmus_STKR1 -------------------------------------------------------A---- ALK2_Mmus_STKR1 ------------------------------------------------------PG---- ALK1_Mmus_STKR1 -------------------------------------------------------E---- ACTR2B_Mmus_STKR2 ------------------------------------------------------TY---- ACTR2_Mmus_STKR2 ------------------------------------------------------TS---- daf-4_Cele_STKR2 ------------------------------------------------------SDNSAL daf-1_Cele_STKR1 ------------------------------------------------------------ BMPR1A_Hsap_STKR1 ------------------------------------------------------F----- BMPR1B_Hsap_STKR1 ------------------------------------------------------V----- BMPR2_Hsap_STKR2 ------------------------------------------------------P----- ALK7_Hsap_STKR1 -------------------------------------------------------N---- ALK4_Hsap_STKR1 -------------------------------------------------------E---- tkv_Dmel_STKR1 ------------------------------------------------------PD---- put_Dmel_STKR2 ------------------------------------------------------TQ---- SAX_Dmel_STKR1 ------------------------------------------------------TV---- wit_Dmel_STKR2 ------------------------------------------------------EG---- BABO_Dmel_STKR1 -------------------------------------------------------Y---- TGFBR1_Mmus_STKR1 -------------------------------------------------------Q---- TGFBR2_Mmus_STKR2 ------------------------------------------------------------ sma-6_Cele_STKR1 ------------------------------------------------------YD---- ALK2_Hsap_STKR1 ------------------------------------------------------PG---- ALK1_Hsap_STKR1 -------------------------------------------------------E---- ACTR2B_Hsap_STKR2 ------------------------------------------------------TY---- ACTR2_Hsap_STKR2 ------------------------------------------------------TS---- TGFbR1_Spur_STKR1 ------------------------------------------------------------ ALK2_Spur_STKR1 ------------------------------------------------------------ BMPR1_Spur_STKR1 ------------------------------------------------------TE---- TGFbRII_Spur_STKR2 ------------------------------------------------------PSS--- ACTR2_Spur_STKR2 ------------------------------------------------------TV---- BMPR2_Spur_STKR2 ------------------------------------------------------TQ---- AqueK680_Aque_STKR1 ------------------------------------------------------PT---- AqueK681_Aque_STKR1 ------------------------------------------------------TN---- AqueK682_Aque_STKR1 ------------------------------------------------------------ AqueK683_Aque_STKR2 FANFYCSHYSDDDIRLTEITENTKIGSLDCTPVQSCFAQLMYSHHHWYLNAMTCGQ---- AqueK684_Aque_STKR2 ------------------------------------------------------SA---- AqueK685_Aque_STKR2 ------------------------------------------------------TV---- AqueK686_Aque_STKR2 ------------------------------------------------------TG---- TGFbR2_Hsap_STKR2 ----NP--D-----------------------------------------LLLVIFQVTG TGFbR1_Hsap_STKR1 ----SP--G------------------------------------LGP-VE-LAAV-I-- MISR2_Hsap_STKR2 ----SQ--GP-Q----------A----------------------APG-ESIWMAL-V-- MISR2_Mmus_STKR2 ----PQ--EP-Q----------A----------------------TPG-GPVWMAL-L-- BMPR2_Mmus_STKR2 -----------P----------H----------------------SFN-RD-ETII-I-- BMPR1B_Mmus_STKR1 ---------------------------------------------DGP-IHHKALL-I-- BMPR1A_Mmus_STKR1 ---------------------------------------------DGS-IRWLVVL-I-- ALK7_Mmus_STKR1 ----AP--R------------------------------------LGP-TE-LTVV-I-- ALK4_Mmus_STKR1 ----HP--SM-----------------------------------WGP-VE-LVGI-I-- ALK2_Mmus_STKR1 ----TQ--NF-----------------------------------H---LEVGLII-L-- ALK1_Mmus_STKR1 ----EP--EV-----------------------------------D---AHLP-LI-L-- ACTR2B_Mmus_STKR2 ----EP--PP-----------------------------------TAP-TLLTVLA-Y-- ACTR2_Mmus_STKR2 ----NP--VT-----------------------------------PKP-PYYNILL-Y-- daf-4_Cele_STKR2 LWASTP--SN-MDLE-------S---------------------LDKF-PFYWIII-I-- daf-1_Cele_STKR1 ----GP--QQ-----------------------------------S---ST--WLI-L-- BMPR1A_Hsap_STKR1 ---------------------------------------------DGS-IRWLVLL-I-- BMPR1B_Hsap_STKR1 ---------------------------------------------DGP-IHHRALL-I-- BMPR2_Hsap_STKR2 -----------P----------H----------------------SFN-RD-ETII-I-- ALK7_Hsap_STKR1 ----AP--K------------------------------------LGP-ME-LAII-I-- ALK4_Hsap_STKR1 ----HP--SM-----------------------------------WGP-VE-LVGI-I-- tkv_Dmel_STKR1 ----LP--VS-----------------------------------SES-LHTLAVF-G-- put_Dmel_STKR2 ----VP--KE-K----------T---------------------QDGS-NLIYIYI-G-- SAX_Dmel_STKR1 ----IT--AD-----------------------------------T---SSISKML-V-- wit_Dmel_STKR2 ----RTSITNRA----------T----------------------EKQ-HQSFLAS-T-- BABO_Dmel_STKR1 ----VP--HR-----------------------------------LTS-WE-FVAI-I-- TGFBR1_Mmus_STKR1 ----SA--G------------------------------------LGP-VE-LAAV-I-- TGFBR2_Mmus_STKR2 ----SP--D-----------------------------------------LLLVIIQVTG sma-6_Cele_STKR1 ----SP--LE-----------------------------------NMTRGGKMFIM-V-- ALK2_Hsap_STKR1 ----TQ--NF-----------------------------------H---LEVGLII-L-- ALK1_Hsap_STKR1 ----QP--GT-----------------------------------D---GQLA-LI-L-- ACTR2B_Hsap_STKR2 ----EP--PP-----------------------------------TAP-TLLTVLA-Y-- ACTR2_Hsap_STKR2 ----NP--VT-----------------------------------PKP-PYYNILL-Y-- TGFbR1_Spur_STKR1 ------------------------------------------------------------ ALK2_Spur_STKR1 ----TE--G--------------------------------------------------- BMPR1_Spur_STKR1 ----LP--GV-E--D-------T---------------------YNTT-VHQIALL-I-- TGFbRII_Spur_STKR2 ----EP--DATP----------TKTKGPPIENTDPNKTEEGRKGQMLD-REILVIV-V-- ACTR2_Spur_STKR2 ----TQ--TT-V--TGSNIDEKK---------------------KKNE-MLTKTIL-Y-- BMPR2_Spur_STKR2 ----YKVISD-Q----------M----------------------NHE-ME-RTIL-I-- AqueK680_Aque_STKR1 ----VS--SN------------------------------------DP-SLYIIIL-V-- AqueK681_Aque_STKR1 ----DP--QQ-----------------------------------I---SD-LNTV-I-- AqueK682_Aque_STKR1 ------------------------------------------------------------ AqueK683_Aque_STKR2 ----SP--GH-----------------------------------TVT-VGFWSAI---- AqueK684_Aque_STKR2 ---T-Q--TA-S---------------------------------SNRVVYPSVFA-A-- AqueK685_Aque_STKR2 --------TS-T----------A----------------------AVTIGLASGIS-I-- AqueK686_Aque_STKR2 ---VIP--ST-D----------T----------------------MVTIILSSVIA-F-- TGFbR2_Hsap_STKR2 ISLLPPLGVAISVII-I--FYCYRVNRQQKL----S--S-TWE-TGKTR----------- TGFbR1_Hsap_STKR1 -AG-PVCFVCISLML-MVYIC-HNRTVIHH-----RVP--NEE-DPSLD----R------ MISR2_Hsap_STKR2 -LLGLFLLLLLLLGS-IILALLQRKNY-RV-----RGE--PVP-EPRP------------ MISR2_Mmus_STKR2 -LLGMFLVL--LLSS-IILALLQRKAC-RV-----QGG--SDP-E--P------------ BMPR2_Mmus_STKR2 -ALASVSVLAVLIVA-LCFGYRMLTGD-RK-----QGL-HSMN-MMEA------------ BMPR1B_Mmus_STKR1 -SV-TVCSLLLVLII-L-FCYFRYKRQ-EA-----RPR-YSIG-LE-QD----E------ BMPR1A_Mmus_STKR1 -SM-AVCIVAMIIFS-SCFCYKHYCKSISS-----RGR-YNRD-LE-QD----E------ ALK7_Mmus_STKR1 -TV-PVCLLSIAAML-TIWACQDRQCTYRK-----TKR-HNVE-EALAE----Y------ ALK4_Mmus_STKR1 -AG-PVFLLFLIIII-VFLVINYHQRVYHN-----RQR-LDME-DPSCE----------- ALK2_Mmus_STKR1 -SV-VFAVCLLACIL-GVALRKFKRRNQER-----LN-PRDVE-YGTIE----G-LIT-- ALK1_Mmus_STKR1 -GP-VLALPVLVALG-ALGLWRVRRRQEKQ-----RD--LHSD-LGESS----L-ILK-- ACTR2B_Mmus_STKR2 -SLLPIGGLSLIVL---LAFWMYRHRKPPYG----HVD---IH-E----VRQCQRWAGR- ACTR2_Mmus_STKR2 -SLVPLMLIAGIVI---CAFWVYRHHKMAYP----PVL---V------------------ daf-4_Cele_STKR2 -ALSVILCIALLIL--AYVGWKFQQNKKEEI----KKQ-QKIKFD----MEKT------- daf-1_Cele_STKR1 -TILAL-LTFI-VLL-GIAIFLTRKSWEAKFDWYIRFKP-KPG-DPLRETENNVPMVTMG BMPR1A_Hsap_STKR1 -SM-AVCIIAMIIFS-SCFCYKHYCKSISS-----RRR-YNRD-LE-QD----E------ BMPR1B_Hsap_STKR1 -SV-TVCSLLLVLII-L-FCYFRYKRQ-ET-----RPR-YSIG-LE-QD----E------ BMPR2_Hsap_STKR2 -ALASVSVLAVLIVA-LCFGYRMLTGD-RK-----QGL-HSMN-MMEA------------ ALK7_Hsap_STKR1 -TV-PVCLLSIAAML-TVWACQGRQCSYRK-----KKR-PNVE-EPLSE----C------ ALK4_Hsap_STKR1 -AG-PVFLLFLIIII-VFLVINYHQRVYHN-----RQR-LDME-DPSCE----------- tkv_Dmel_STKR1 -SI-IISLSVFMLIV-ASLCFTYKRRE-KL-----RKQ-PRLI-NSMCN----------- put_Dmel_STKR2 -TSV-FSVLMVIVG---MGLLLYRRRKQAHF----N-E---I------------------ SAX_Dmel_STKR1 -AV-LGPFLVIALLG-AVTIFFIRRSHRKR-----LAASRTKQ-DPEAYLVNDE-LLR-- wit_Dmel_STKR2 -MLGLAGGLTALTIG-IFLAVQYCRTA-KE-----KPE--PEE-SPLA------------ BABO_Dmel_STKR1 -LG-ATLFICFTGTS-TWYYC-QRRKRMAS-----GRT-FAKE-DSAYD----------- TGFBR1_Mmus_STKR1 -AG-PVCFVCIALML-MVYIC-HNRTVIHH-----RVP--NEE-DPSLD----R------ TGFBR2_Mmus_STKR2 VSLLPPLGIAIAVII-I--FYCYRVHRQQKL----S--P-SWE-SSKPR----------- sma-6_Cele_STKR1 -F-ATVMSV-FAVIG-CIYLCITRAEEKSKA----RARAKTVS-LK-TE----S------ ALK2_Hsap_STKR1 -SV-VFAVCLLACLL-GVALRKFKRRNQER-----LN-PRDVE-YGTIE----G-LIT-- ALK1_Hsap_STKR1 -GP-VLALLALVALG-VLGLWHVRRRQEKQ-----RG--LHSE-LGESS----L-ILK-- ACTR2B_Hsap_STKR2 -SLLPIGGLSLIVL---LAFWMYRHRKPPYG----HVD---IH----------------- ACTR2_Hsap_STKR2 -SLVPLMLIAGIVI---CAFWVYRHHKMAYP----PVL---V------------------ TGFbR1_Spur_STKR1 ------------------------------------------------------------ ALK2_Spur_STKR1 ------------------------------------------------------------ BMPR1_Spur_STKR1 -SV-TFCAAAFIIAL-TFF-YLRYKKR-EV-----RRR-YDFE-VAQQD----D------ TGFbRII_Spur_STKR2 CSVVPAVLLTIVIAV-A--GYIHFTRYRQPM----N--D-ELN-TQ-TQ----------- ACTR2_Spur_STKR2 -SIVPIVAIALVII---MLYWMCRRHRYH-S----LIA---I------------------ BMPR2_Spur_STKR2 -AVIPIFCVSVAIAI-MYFIFRMRLRS-TK-----AQM-SQLP-MIEA------------ AqueK680_Aque_STKR1 -TIISSCIILIILFF-ALFIFCKRKRDRRLP----RQRTNDPD-VHLTE----P-HHS-- AqueK681_Aque_STKR1 -PVIVVLLVIAAVII-LLAIFIHRRSTKSNN----RGKQ-RG-------NEGST-K---- AqueK682_Aque_STKR1 ------------------------------------------------------------ AqueK683_Aque_STKR2 -GSLSMIIIGIVCALWITIAFKWKTTRSKY-----RKA-IDYS-LSLD------------ AqueK684_Aque_STKR2 -LLLIMVLILCSIS--IILCR-VR-VAFRK-----RLDMSNYQ-LS-------------- AqueK685_Aque_STKR2 -LALMIALIAVVMM--LILAYSWRKHSPKF-----HRCSHQIQ-FSS------------- AqueK686_Aque_STKR2 -LAITLAIIGLLIAC-TLVCYC-RKYSSNS-----RRHSHQIQ-FP-------------- TGFbR2_Hsap_STKR2 -----------------------------KLMEFSEHCAII-LEDD--RSD----I-SS- TGFbR1_Hsap_STKR1 -----------------------------PFISEGTTLKDL-IYDM--TTS----G-SG- MISR2_Hsap_STKR2 ----------------------------------------------------------D- MISR2_Mmus_STKR2 ----------------------------------------------------------G- BMPR2_Mmus_STKR2 ----------------------------------------------------------A- BMPR1B_Mmus_STKR1 -----------------------------TYIPPGESLRDL-IEQS--QSS----G-SG- BMPR1A_Mmus_STKR1 -----------------------------AFIPVGESLKDL-IDQS--QSS----G-SG- ALK7_Mmus_STKR1 -----------------------------SLVNAGKTLKDL-IYDA--TAS----G-SG- ALK4_Mmus_STKR1 -----------------------------MCLSKDKTLQDL-VYDL--STS----G-SG- ALK2_Mmus_STKR1 ------------------------------TNVGDSTLAEL-LDHS--CTS----G-SG- ALK1_Mmus_STKR1 -----------------------------ASEQADSMLGDF-LDSD--CTT----G-SG- ACTR2B_Mmus_STKR2 ----------------------------------RDGCADS-FKPLPFQDP----G-PP- ACTR2_Mmus_STKR2 ----------------------------------------------PTQDP----G-PP- daf-4_Cele_STKR2 ----------------------------------------------DALEA----GNVPL daf-1_Cele_STKR1 DGAGSSVPEVAPIEQQGSTMSTSAGNSFPPGIMP-NNMKDM-LDVL-EETS----G-SG- BMPR1A_Hsap_STKR1 -----------------------------AFIPVGESLKDL-IDQS--QSS----G-SG- BMPR1B_Hsap_STKR1 -----------------------------TYIPPGESLRDL-IEQS--QSS----G-SG- BMPR2_Hsap_STKR2 ----------------------------------------------------------A- ALK7_Hsap_STKR1 -----------------------------NLVNAGKTLKDL-IYDV--TAS----G-SG- ALK4_Hsap_STKR1 -----------------------------MCLSKDKTLQDL-VYDL--STS----G-SG- tkv_Dmel_STKR1 --------------------------------SQLSPLSQL-VE----QSS----G-SG- put_Dmel_STKR2 ----------------------------------------------PTHEA----E-IT- SAX_Dmel_STKR1 -----------------------------ATSAGDSTLREY-LQHS--VTS----G-SG- wit_Dmel_STKR2 ----------------------------------------------------------P- BABO_Dmel_STKR1 -----------------------------PILNGNTTIHDI-IEM---TTS----G-SGS TGFBR1_Mmus_STKR1 -----------------------------PFISEGTTLKDL-IYDM--TTS----G-SG- TGFBR2_Mmus_STKR2 -----------------------------KLMDFSDNCAII-LEDD--RSD----I-SS- sma-6_Cele_STKR1 -----------------------------TYMES--------KSML--EDS----G-SG- ALK2_Hsap_STKR1 ------------------------------TNVGDSTLADL-LDHS--CTS----G-SG- ALK1_Hsap_STKR1 -----------------------------ASEQGDSMLGDL-LDSD--CTT----G-SG- ACTR2B_Hsap_STKR2 ------------------------------------------------EDP----G-PP- ACTR2_Hsap_STKR2 ----------------------------------------------PTQDP----G-PP- TGFbR1_Spur_STKR1 -----------------------------------------------------------I ALK2_Spur_STKR1 -----------------------------------LFCFDL-FDHS--NTS----G-SG- BMPR1_Spur_STKR1 -----------------------------SFIGPGETLSEL-LEKS--SAS----G-SG- TGFbRII_Spur_STKR2 ------------------------------TSNTESTSIDMTTDES--ETKRLGEY-SP- ACTR2_Spur_STKR2 ----------------------------------------------PTTE--------P- BMPR2_Spur_STKR2 ----------------------------------------------------------P- AqueK680_Aque_STKR1 -------------------------------NGNGNDLTSF-LQMS--FTS----G-SG- AqueK681_Aque_STKR1 -------------------------------VRP-EDVERE-MEIL--STS----G-SG- AqueK682_Aque_STKR1 ------------------------------------------------------------ AqueK683_Aque_STKR2 -------------------------------------------------------N-SN- AqueK684_Aque_STKR2 ------------------------------------------------------------ AqueK685_Aque_STKR2 ------------------------------------------------------------ AqueK686_Aque_STKR2 ------------------------------------------------------------ TGFbR2_Hsap_STKR2 ----TCANNINHNTELLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPY--EE TGFbR1_Hsap_STKR1 ----SGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRG------EEVAVKIFSS--RE MISR2_Hsap_STKR2 ----SGRDWSVELQELPELCFSQVIREGGHAVVWAGQLQG------KLVAIKAFPP--RS MISR2_Mmus_STKR2 ----SGGDCSEELPELAELRFSQVIQEGGHAVVWAGRLQG------EMVAIKAFPP--RA BMPR2_Mmus_STKR2 ----A----AEPSLDLDNLKLLELIGRGRYGAVYKGSLDE------RPVAVKVFSF--AN BMPR1B_Mmus_STKR1 ----SGLPLLVQRTIAKQIQMVKQIGKGRYGEVWMGKWRG------EKVAVKVFFT--TE BMPR1A_Mmus_STKR1 ----SGLPLLVQRTIAKQIQMVRQVGKGRYGEVWMGKWRG------EKVAVKVFFT--TE ALK7_Mmus_STKR1 ----SGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCG------EDVAVKIFSS--RD ALK4_Mmus_STKR1 ----SGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRG------GDVAVKIFSS--RE ALK2_Mmus_STKR1 ----SGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQG------ENVAVKIFSS--RD ALK1_Mmus_STKR1 ----SGLPFLVQRTVARQVALVECVGKGRYGEVWRGSWHG------ESVAVKIFSS--RD ACTR2B_Mmus_STKR2 --------PPSPLVGLKPLQLLEIKARGRFGCVWKAQLMN------DFVAVKIFPL--QD ACTR2_Mmus_STKR2 --------PPSPLLGLKPLQLLEVKARGRFGCVWKAQLLN------EYVAVKIFPI--QD daf-4_Cele_STKR2 VEPEEEMIEMVETPKELPITDFQLISKGRFGKVFKAQYTPDSG-EKRLVAVKKLNE--FQ daf-1_Cele_STKR1 ----MGPTTLHKLTIGGQIRLTGRVGSGRFGNVSRGDYRG------EAVAVKVFNA--LD BMPR1A_Hsap_STKR1 ----SGLPLLVQRTIAKQIQMVRQVGKGRYGEVWMGKWRG------EKVAVKVFFT--TE BMPR1B_Hsap_STKR1 ----SGLPLLVQRTIAKQIQMVKQIGKGRYGEVWMGKWRG------EKVAVKVFFT--TE BMPR2_Hsap_STKR2 ----A----SEPSLDLDNLKLLELIGRGRYGAVYKGSLDE------RPVAVKVFSF--AN ALK7_Hsap_STKR1 ----SGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCG------EDVAVKIFSS--RD ALK4_Hsap_STKR1 ----SGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRG------GDVAVKIFSS--RE tkv_Dmel_STKR1 ----SGLPLLVQRTIAKQIQMVRLVGKGRYGEVWLAKWRD------ERVAVKTFFT--TE put_Dmel_STKR2 --------NSSPLLSNRPIQLLEQKASGRFGDVWQAKLNN------QDVAVKIFRM--QE SAX_Dmel_STKR1 ----SGLPLLVQRTLAKQVTLIECIGRGKYGEVWRGHWHG------ESIAVKIFFS--RD wit_Dmel_STKR2 ----SGPGYSSNLRNVDNMNLIGMLGSGKYGTVMKGLLHD------QEVAVKIYPE--EH BABO_Dmel_STKR1 ----AGLPLLVQRSIARQVQLCHVIGKGRFGEVWRGRWRG------ENVAVKIFSS--RE TGFBR1_Mmus_STKR1 ----SGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRG------EEVAVKIFSS--RE TGFBR2_Mmus_STKR2 ----TCANNINHNTELLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPY--EE sma-6_Cele_STKR1 ----SGQAALIQRTVRQDLTIIKTIGQGRYGEVRKALYRG------SYVAVKTFYT--TD ALK2_Hsap_STKR1 ----SGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQG------ENVAVKIFSS--RD ALK1_Hsap_STKR1 ----SGLPFLVQRTVARQVALVECVGKGRYGEVWRGLWHG------ESVAVKIFSS--RD ACTR2B_Hsap_STKR2 --------PPSPLVGLKPLQLLEIKARGRFGCVWKAQLMN------DFVAVKIFPL--QD ACTR2_Hsap_STKR2 --------PPSPLLGLKPLQLLEVKARGRFGCVWKAQLLN------EYVAVKIFPI--QD TGFbR1_Spur_STKR1 ----QGLPLLVQRTIARQIVIQDCIGKGRYGEVYRGKWRG------ESVAVKIFSS--RE ALK2_Spur_STKR1 ----SGLPYLVQRTVARQINLLQQVGKGRYGEVWMGTWQG------DTVAVKIFSS--ID BMPR1_Spur_STKR1 ----SGLPLLVQRTIAKQVQLIRKIGKGRYGEVWKAKWRG------ENVAVKIYFT--AE TGFbRII_Spur_STKR2 ----PDSPLHL-NGNYLPITLDELIGKGRFGAVWRAHWKINNGTKERTVAVKVFLE--YD ACTR2_Spur_STKR2 --------TPSPMNSLPPIQLLEIKARGRFGAVWKASCLN------DIVAVKVFPI--QD BMPR2_Spur_STKR2 ----P----PEPTFDLDQLKMMELVGQGRYCNVYRAALSE------NEVAVKVFTG--SS AqueK680_Aque_STKR1 ----AGMPFLVKRTIARSILLGESIGGGRFGQVYVGHYQG------ERYAVKKFFS--KD AqueK681_Aque_STKR1 ----MGERVLTSRTIAMDITIHEHLGRGTYGSISRCTYRG------NTFAVKRFTT--IN AqueK682_Aque_STKR1 -----------------DVTKISVIGQGRFGKVWRCSYEE------KHIAMKVFKN--MH AqueK683_Aque_STKR2 ----STL------IYSHQIV-----------TVRKA-E------NNRIIAVYKSTV--SA AqueK684_Aque_STKR2 ----SPSP-----TLYDSPEFMKIIGHGRFARVYHARMGT------RDVAIKIFNGTLQA AqueK685_Aque_STKR2 --ETSTIIELDEEPGLPPFQLIQSIGNGRFGSVWKALYEK------ETVAVRVFSQ--RH AqueK686_Aque_STKR2 ---AAPNIELDERSAPLPFQLLQPIGNGRFGSVWKALYNN------ETVAVKALSL--HH : *: TGFbR2_Hsap_STKR2 YASWKTEKDIFS--DIN---LKHENILQFLTAEERKT---ELGKQYWLITAFHAKGNLQE TGFbR1_Hsap_STKR1 ERSWFREAEIYQ--TVM---LRHENILGFIAADNKDN---GTWTQLWLVSDYHEHGSLFD MISR2_Hsap_STKR2 VAQFQAERALYE--LPG---LQHDHIVRFITASRGGPG--RLLSGPLLVLELHPKGSLCH MISR2_Mmus_STKR2 VAQFRAERAVYQ--LLG---LQHDHIVRFITAGQGGPG--PLPSGPLLVLELYPKGSLCH BMPR2_Mmus_STKR2 RQNFINEKNIYR--VPL---MEHDNIARFIVGDERLTA--DGRMEYLLVMEYYPNGSLCK BMPR1B_Mmus_STKR1 EASWFRETEIYQ--TVL---MRHENILGFIAADIKGT---GSWTQLYLITDYHENGSLYD BMPR1A_Mmus_STKR1 EASWFRETEIYQ--TVL---MRHENILGFIAADIKGT---GSWTQLYLITDYHENGSLYD ALK7_Mmus_STKR1 ERSWFREAEIYQ--TVM---LRHENILGFIAADNKDN---GTWTQLWLVSEYHEQGSLYD ALK4_Mmus_STKR1 ERSWFREAEIYQ--TVM---LRHENILGFIAADNKDN---GTWTQLWLVSDYHEHGSLFD ALK2_Mmus_STKR1 EKSWFRETELYN--TVM---LRHENILGFIASDMTSR---HSSTQLWLITHYHEMGSLYD ALK1_Mmus_STKR1 EQSWFRETEIYN--TVL---LRHDNILGFIASDMTSR---NSSTQLWLITHYHEHGSLYD ACTR2B_Mmus_STKR2 KQSWQSEREIFS--TPG---MKHENLLQFIAAEKRGS---NLEVELWLITAFHDKGSLTD ACTR2_Mmus_STKR2 KQSWQNEYEVYS--LPG---MKHENILQFIGAEKRGT---SVDVDLWLITAFHEKGSLSD daf-4_Cele_STKR2 KASFLAEKRIFD--ELNEYPKWYKSIVEFVCAEKIG-------DEYWIVTEFHERLSLYE daf-1_Cele_STKR1 EPAFHKETEIFE--TRM---LRHPNVLRYIGSDRVDT---GFVTELWLVTEYHPSGSLHD BMPR1A_Hsap_STKR1 EASWFRETEIYQ--TVL---MRHENILGFIAADIKGT---GSWTQLYLITDYHENGSLYD BMPR1B_Hsap_STKR1 EASWFRETEIYQ--TVL---MRHENILGFIAADIKGT---GSWTQLYLITDYHENGSLYD BMPR2_Hsap_STKR2 RQNFINEKNIYR--VPL---MEHDNIARFIVGDERVTA--DGRMEYLLVMEYYPNGSLCK ALK7_Hsap_STKR1 ERSWFREAEIYQ--TVM---LRHENILGFIAADNKDN---GTWTQLWLVSEYHEQGSLYD ALK4_Hsap_STKR1 ERSWFREAEIYQ--TVM---LRHENILGFIAADNKDN---GTWTQLWLVSDYHEHGSLFD tkv_Dmel_STKR1 EASWFRETEIYQ--TVL---MRHDNILGFIAADIKGN---GSWTQMLLITDYHEMGSLHD put_Dmel_STKR2 KESWTTEHDIYK--LPR---MRHPNILEFLGVEKHMD-----KPEYWLISTYQHNGSLCD SAX_Dmel_STKR1 EESWKRETEIYS--TIL---LRHENILGFIGSDMTSR---NSCTQLWLMTHYYPLGSLFD wit_Dmel_STKR2 HQYYVNERNIYA--LPL---MECPALLSYFGYDERCTM--DGRMEYQLVLSLAPLGCLQD BABO_Dmel_STKR1 ECSWFREAEIYQ--TVM---LRHENILGFIAADNKDN---GTWTQLWLVTDYHENGSLFD TGFBR1_Mmus_STKR1 ERSWFREAEIYQ--TVM---LRHENILGFIAADNKDN---GTWTQLWLVSDYHEHGSLFD TGFBR2_Mmus_STKR2 YSSWKTEKDIFS--DIN---LKHENILQFLTAEERKT---ELGKQYWLITAFHAKGNLQE sma-6_Cele_STKR1 EDSWKNERDVYQ--TNM---INHENILQFVAADIWSEE--DSMTKMLLITDYHELGSLSD ALK2_Hsap_STKR1 EKSWFRETELYN--TVM---LRHENILGFIASDMTSR---HSSTQLWLITHYHEMGSLYD ALK1_Hsap_STKR1 EQSWFRETEIYN--TVL---LRHDNILGFIASDMTSR---NSSTQLWLITHYHEHGSLYD ACTR2B_Hsap_STKR2 KQSWQSEREIFS--TPG---MKHENLLQFIAAEKRGS---NLEVELWLITAFHDKGSLTD ACTR2_Hsap_STKR2 KQSWQNEYEVYS--LPG---MKHENILQFIGAEKRGT---SVDVDLWLITAFHEKGSLSD TGFbR1_Spur_STKR1 ERSWFREAEIYQ--TVM---LRHENILGFIAADNKDN---GTWTQLILVSDYHENGSLFD ALK2_Spur_STKR1 EKSWFRETEIYN--TVM---LRHENILAFFASDMTSR---QSCTQLWLIMEYHERGSLYD BMPR1_Spur_STKR1 EASWFRETDIYQ--TVL---MRHTSILSFIAADIRGS---GAYTQLFLITEYHEWGSLYD TGFbRII_Spur_STKR2 SASWNVEKELFTDHSVM---MRHEHIVQFISAEVRRVSVTSPTRQYWLITKYYKNGSLHD ACTR2_Spur_STKR2 RNSWANEREIYS--LPH---MHHENLLHFIATEKHGE---GLEVEYWLISEFHHHGSLCD BMPR2_Spur_STKR2 KQCYMNELDIMG--LPH---MEHSNLLQYVGSGDRMGE--DGWVEHLLVVDMISKGSLMS AqueK680_Aque_STKR1 EQSWFHESDIYN--SVN---LRHDNILTCFATDMLSN---NGVTELWLITQYHPRGSLFE AqueK681_Aque_STKR1 ESSFRRELGIYS--F-S---LTQTNILTYIAADMITI---DGVMECWLILQYCPRGSLYM AqueK682_Aque_STKR1 MAVFKREVEIYD--TYM---LYHENILRFIGHDQIEF---ADTIELRLYTEYHENGTLQD AqueK683_Aque_STKR2 LSQWKIERDIYL--TPE---LRHESILTLLRAKRVK-D-----IGYQLVLKGSITGSLYQ AqueK684_Aque_STKR2 KGSWTQEKDIYA--TER---LEHENILKFLYHDHRFH---EGQDTLWLIFDYHSNGSLYD AqueK685_Aque_STKR2 RTSWQNERDIHL--LNS---TPHENILKFISSESRGR---GPSSEYFIITEYLPLGSLHQ AqueK686_Aque_STKR2 KLSWQNERDIHL--LDS---TPHENILKFISSESRGR---GSSSEYFIITEYLPLGSLHQ : * : : . : * TGFbR2_Hsap_STKR2 YLTR-HVI-SWEDLRKLGSSLARGIAHLHSDHTP-C-G--RPKMPIVHRDLKSSNILVKN TGFbR1_Hsap_STKR1 YLNR-YTV-TVEGMIKLALSTASGLAHLHMEIV-GT----QGKPAIAHRDLKSKNILVKK MISR2_Hsap_STKR2 YLTQ-YTS-DWGSSLRMALSLAQGLAFLHEERWQNG----QYKPGIAHRDLSSQNVLIRE MISR2_Mmus_STKR2 YLTQ-YTS-DWGSSLRMALSLAEGLAFLHEERWQDG----QYKPGIAHRDLSSQNVLIRE BMPR2_Mmus_STKR2 YLSL-HTS-DWVSSCRLAHSVTRGLAYLHTELPRGD----HYKPAISHRDLNSRNVLVKN BMPR1B_Mmus_STKR1 YLKS-TTL-DAKSMLKLAYSSVSGLCHLHTEIF-ST----QGKPAIAHRDLKSKNILVKK BMPR1A_Mmus_STKR1 FLKC-ATL-DTRALLKLAYSAACGLCHLHTEIY-GT----QGKPAIAHRDLKSKNILIKK ALK7_Mmus_STKR1 YLNR-NIV-TVAGMVKLALSIASGLAHLHMEIV-GT----QGKPAIAHRDIKSKNILVKK ALK4_Mmus_STKR1 YLNR-YTV-TIEGMIKLALSAASGLAHLHMEIV-GT----QGKPGIAHRDLKSKNILVKK ALK2_Mmus_STKR1 YLQL-TTL-DTVSCLRIVLSIASGLAHLHIEIF-GT----QGKSAIAHRDLKSKNILVKK ALK1_Mmus_STKR1 FLQR-QTL-EPQLALRLAVSAACGLAHLHVEIF-GT----QGKPAIAHRDLKSRNVLVKS ACTR2B_Mmus_STKR2 YLKG-NII-TWNELCHVAETMSRGLSYLHEDVP-WCRG-EGHKPSIAHRDFKSKNVLLKS ACTR2_Mmus_STKR2 FLKA-NVV-SWNELCHIAETMARGLAYLHEDIP-GLK--DGHKPAISHRDIKSKNVLLKN daf-4_Cele_STKR2 LLKN-NVI-SITSANRIIMSMIDGLQFLHDDRP-YFFG-H-PKKPIIHRDIKSKNILVKS daf-1_Cele_STKR1 FLLE-NTV-NIETYYNLMRSTASGLAFLHNQIG-GSK--ESNKPAMAHRDIKSKNIMVKN BMPR1A_Hsap_STKR1 FLKC-ATL-DTRALLKLAYSAACGLCHLHTEIY-GT----QGKPAIAHRDLKSKNILIKK BMPR1B_Hsap_STKR1 YLKS-TTL-DAKSMLKLAYSSVSGLCHLHTEIF-ST----QGKPAIAHRDLKSKNILVKK BMPR2_Hsap_STKR2 YLSL-HTS-DWVSSCRLAHSVTRGLAYLHTELPRGD----HYKPAISHRDLNSRNVLVKN ALK7_Hsap_STKR1 YLNR-NIV-TVAGMIKLALSIASGLAHLHMEIV-GT----QGKPAIAHRDIKSKNILVKK ALK4_Hsap_STKR1 YLNR-YTV-TIEGMIKLALSAASGLAHLHMEIV-GT----QGKPGIAHRDLKSKNILVKK tkv_Dmel_STKR1 YLSM-SVI-NPQKLQLLAFSLASGLAHLHDEIF-GT----PGKPAIAHRDIKSKNILVKR put_Dmel_STKR2 YLKS-HTI-SWPELCRIAESMANGLAHLHEEIP-ASKT-DGLKPSIAHRDFKSKNVLLKS SAX_Dmel_STKR1 HLNR-NAL-SHNDMVWICLSIANGLVHLHTEIF-GK----QGKPAMAHRDLKSKNILVTS wit_Dmel_STKR2 WLIA-NTL-TFSECCGMLRSITRGISHLHTELRLGD----QHKPCVAHRDINTRNVLVQA BABO_Dmel_STKR1 YLTT-HPV-DTNTMLNMSLSIATGLAHLHMDIV-GT----RGKPAIAHRDLKSKNILVKS TGFBR1_Mmus_STKR1 YLNR-YTV-TVEGMIKLALSTASGLAHLHMEIV-GT----QGKPAIAHRDLKSKNILVKK TGFBR2_Mmus_STKR2 YLTR-HVI-SWEDLRKLGSSLARGIAHLHSDHTP-C-G--RPKMPIVHRDLKSSNILVKN sma-6_Cele_STKR1 YLCREETL-TTDEALRLIHSCICGIEHLHAAVH-GTG--SFRKPEIAHRDIKSKNIIVKR ALK2_Hsap_STKR1 YLQL-TTL-DTVSCLRIVLSIASGLAHLHIEIF-GT----QGKPAIAHRDLKSKNILVKK ALK1_Hsap_STKR1 FLQR-QTL-EPHLALRLAVSAACGLAHLHVEIF-GT----QGKPAIAHRDFKSRNVLVKS ACTR2B_Hsap_STKR2 YLKG-NII-TWNELCHVAETMSRGLSYLHEDVP-WCRG-EGHKPSIAHRDFKSKNVLLKS ACTR2_Hsap_STKR2 FLKA-NVV-SWNELCHIAETMARGLAYLHEDIP-GLK--DGHKPAISHRDIKSKNVLLKN TGFbR1_Spur_STKR1 YLNS-HVI-DVPGMLRMALSIATGLAHLHMEIM-GM----QGKPAIAHRDIKSKNILVKR ALK2_Spur_STKR1 YLNR-HVL-DARQMCRLALTACSGLVHLHTEIT-CN----NSKPAIAHRDIKTKNILVKR BMPR1_Spur_STKR1 FLNV-NIL-DSQSMLRLAYSAANGLAHLHTEIC-GM----QGKPAIAHRDVKSSNIMVRK TGFbRII_Spur_STKR2 YLRQ-RSV-NWIDLCKLCGSAARGLAHLHAETYG-SHG--LHKVPVAHRDLKSTNILVKD ACTR2_Spur_STKR2 YLKA-NVI-SWKELCGIAFSMAKGLAYLHEDIP-PTTAIPFVKHSVAHRDFKSKNVLIKN BMPR2_Spur_STKR2 YLRE-NTY-DWHTMCRLAQTTAAGLAHLHQVIDTQV----GLKPAVVHRDINSRNVLVNA AqueK680_Aque_STKR1 ELNR-GGL-TPETTLKFIHSTCRGLAYLHLEIT-GT----QGKPSVAHRDIKSKNILVKN AqueK681_Aque_STKR1 ELTS-SPP-SLETGVRMVYSACMGLSYLHSSLQ-GYG--PIAKPRIAHRDIKSKNILMKT AqueK682_Aque_STKR1 YLKS-KPVFHFPECHQMAVSLSSGLTYLHKTI-VAGK----IKPGIAHRDLKSSNILVKT AqueK683_Aque_STKR2 YLQS-HSP-DELEAAKITHSMSSGLAHLHYMESSQSHS-KYRVITIAHCNINSHNILMKE AqueK684_Aque_STKR2 YLQL-HRL-TFDELFSLCLSGAAGLEHLHSVDNCPET----YKPAIAHRDLKSKNILVKK AqueK685_Aque_STKR2 FLRH-NTL-SWEQAWNIMYSITSGITHLHSSSYYS-NGLLADKFSIAHRDIKPSNILVKS AqueK686_Aque_STKR2 FLRH-NTL-SWEQAWNIMYSIASGITHLHSNSYYNSNGLLLEKYSIAHRDIKPSNILVKS * . : *: .** : * :... *::: TGFbR2_Hsap_STKR2 -DLTCCLCDFGLSLRL-------------------------------------------- TGFbR1_Hsap_STKR1 -NGTCCIADLGLAVRH-------------------------------------------- MISR2_Hsap_STKR2 -DGSCAIGDLGLALVL-------------------------------------------- MISR2_Mmus_STKR2 -DRSCAIGDLGLALVL-------------------------------------------- BMPR2_Mmus_STKR2 -DGACVISDFGLSMRL-------------------------------------------- BMPR1B_Mmus_STKR1 -NGTCCIADLGLAVKF-------------------------------------------- BMPR1A_Mmus_STKR1 -NGSCCIADLGLAVKF-------------------------------------------- ALK7_Mmus_STKR1 -CDTCAIADLGLAVKH-------------------------------------------- ALK4_Mmus_STKR1 -NGMCAIADLGLAVRH-------------------------------------------- ALK2_Mmus_STKR1 -NGQCCIADLGLAVMH-------------------------------------------- ALK1_Mmus_STKR1 -NLQCCIADLGLAVMH-------------------------------------------- ACTR2B_Mmus_STKR2 -DLTAVLADFGLAVRF-------------------------------------------- ACTR2_Mmus_STKR2 -NLTACIADFGLALKF-------------------------------------------- daf-4_Cele_STKR2 -DMTTCIADFGLARIY-------------------------------------------- daf-1_Cele_STKR1 -DLTCAIGDLGLSLSK-------------------------------------------- BMPR1A_Hsap_STKR1 -NGSCCIADLGLAVKF-------------------------------------------- BMPR1B_Hsap_STKR1 -NGTCCIADLGLAVKF-------------------------------------------- BMPR2_Hsap_STKR2 -DGTCVISDFGLSMRL-------------------------------------------- ALK7_Hsap_STKR1 -CETCAIADLGLAVKH-------------------------------------------- ALK4_Hsap_STKR1 -NGMCAIADLGLAVRH-------------------------------------------- tkv_Dmel_STKR1 -NGQCAIADFGLAVKY-------------------------------------------- put_Dmel_STKR2 -DLTACIADFGLAMIF-------------------------------------------- SAX_Dmel_STKR1 -NGSCVIADFGLAVTH-------------------------------------------- wit_Dmel_STKR2 -DLSCCIADFGFALKV-------------------------------------------- BABO_Dmel_STKR1 -NLSCAIGDLGLAVRH-------------------------------------------- TGFBR1_Mmus_STKR1 -NGTCCIADLGLAVRH-------------------------------------------- TGFBR2_Mmus_STKR2 -DLTCCLCDFGLSLRL-------------------------------------------- sma-6_Cele_STKR1 -PNVCCIADLGLALRY-------------------------------------------- ALK2_Hsap_STKR1 -NGQCCIADLGLAVMH-------------------------------------------- ALK1_Hsap_STKR1 -NLQCCIADLGLAVMH-------------------------------------------- ACTR2B_Hsap_STKR2 -DLTAVLADFGLAVRF-------------------------------------------- ACTR2_Hsap_STKR2 -NLTACIADFGLALKF-------------------------------------------- TGFbR1_Spur_STKR1 -NGQCAIADLGLAVRH-------------------------------------------- ALK2_Spur_STKR1 -NLTCCIADLGLAVLH-------------------------------------------- BMPR1_Spur_STKR1 -NGTCMIADMSLAARFLSEGNEIDLGQNTRLGTTRYLPPEVLDNVLMSNTFDAFKMADMY TGFbRII_Spur_STKR2 -DGSCAIADFGLAIRL-------------------------------------------- ACTR2_Spur_STKR2 -NTTACIADFGLACVF-------------------------------------------- BMPR2_Spur_STKR2 -EGNCVIGDFGFAMQV-------------------------------------------- AqueK680_Aque_STKR1 -DSTCCIADFGLAVNY-------------------------------------------- AqueK681_Aque_STKR1 -AETCCIADFGLSIAD-------------------------------------------- AqueK682_Aque_STKR1 -DYTLCIADLGLAIKQ-------------------------------------------- AqueK683_Aque_STKR2 -DGTVFLSDFSRSVKF-------------------------------------------- AqueK684_Aque_STKR2 -DMTCCISDFGLAIKF-------------------------------------------- AqueK685_Aque_STKR2 PSGQCVVADFGQAFVL-------------------------------------------- AqueK686_Aque_STKR2 VSGHCVVADLGLAFIL-------------------------------------------- : *:. : TGFbR2_Hsap_STKR2 ------------------------------------------------------------ TGFbR1_Hsap_STKR1 ------------------------------------------------------------ MISR2_Hsap_STKR2 ------------------------------------------------------------ MISR2_Mmus_STKR2 ------------------------------------------------------------ BMPR2_Mmus_STKR2 ------------------------------------------------------------ BMPR1B_Mmus_STKR1 ------------------------------------------------------------ BMPR1A_Mmus_STKR1 ------------------------------------------------------------ ALK7_Mmus_STKR1 ------------------------------------------------------------ ALK4_Mmus_STKR1 ------------------------------------------------------------ ALK2_Mmus_STKR1 ------------------------------------------------------------ ALK1_Mmus_STKR1 ------------------------------------------------------------ ACTR2B_Mmus_STKR2 ------------------------------------------------------------ ACTR2_Mmus_STKR2 ------------------------------------------------------------ daf-4_Cele_STKR2 ------------------------------------------------------------ daf-1_Cele_STKR1 ------------------------------------------------------------ BMPR1A_Hsap_STKR1 ------------------------------------------------------------ BMPR1B_Hsap_STKR1 ------------------------------------------------------------ BMPR2_Hsap_STKR2 ------------------------------------------------------------ ALK7_Hsap_STKR1 ------------------------------------------------------------ ALK4_Hsap_STKR1 ------------------------------------------------------------ tkv_Dmel_STKR1 ------------------------------------------------------------ put_Dmel_STKR2 ------------------------------------------------------------ SAX_Dmel_STKR1 ------------------------------------------------------------ wit_Dmel_STKR2 ------------------------------------------------------------ BABO_Dmel_STKR1 ------------------------------------------------------------ TGFBR1_Mmus_STKR1 ------------------------------------------------------------ TGFBR2_Mmus_STKR2 ------------------------------------------------------------ sma-6_Cele_STKR1 ------------------------------------------------------------ ALK2_Hsap_STKR1 ------------------------------------------------------------ ALK1_Hsap_STKR1 ------------------------------------------------------------ ACTR2B_Hsap_STKR2 ------------------------------------------------------------ ACTR2_Hsap_STKR2 ------------------------------------------------------------ TGFbR1_Spur_STKR1 ------------------------------------------------------------ ALK2_Spur_STKR1 ------------------------------------------------------------ BMPR1_Spur_STKR1 SFGMVLWEIARRCVTRGFIAADIRGSGAYTQLFLITEYHEWGSLYDFLNVNILDSQSMLR TGFbRII_Spur_STKR2 ------------------------------------------------------------ ACTR2_Spur_STKR2 ------------------------------------------------------------ BMPR2_Spur_STKR2 ------------------------------------------------------------ AqueK680_Aque_STKR1 ------------------------------------------------------------ AqueK681_Aque_STKR1 ------------------------------------------------------------ AqueK682_Aque_STKR1 ------------------------------------------------------------ AqueK683_Aque_STKR2 ------------------------------------------------------------ AqueK684_Aque_STKR2 ------------------------------------------------------------ AqueK685_Aque_STKR2 ------------------------------------------------------------ AqueK686_Aque_STKR2 ------------------------------------------------------------ TGFbR2_Hsap_STKR2 ------------------------------------------------------DPTLS- TGFbR1_Hsap_STKR1 ------------------------------------------------------DSATD- MISR2_Hsap_STKR2 ------------------------------------------------------PGLTQP MISR2_Mmus_STKR2 ------------------------------------------------------PGLAQP BMPR2_Mmus_STKR2 ------------------------------------------------------TGNRLV BMPR1B_Mmus_STKR1 ------------------------------------------------------ISDTN- BMPR1A_Mmus_STKR1 ------------------------------------------------------NSDTN- ALK7_Mmus_STKR1 ------------------------------------------------------DSIMN- ALK4_Mmus_STKR1 ------------------------------------------------------DAVTD- ALK2_Mmus_STKR1 ------------------------------------------------------SQSTN- ALK1_Mmus_STKR1 ------------------------------------------------------SQSSD- ACTR2B_Mmus_STKR2 ------------------------------------------------------EPGKP- ACTR2_Mmus_STKR2 ------------------------------------------------------EAGKS- daf-4_Cele_STKR2 ------------------------------------------------------SYDIE- daf-1_Cele_STKR1 ------------------------------------------------------PEDAAS BMPR1A_Hsap_STKR1 ------------------------------------------------------NSDTN- BMPR1B_Hsap_STKR1 ------------------------------------------------------ISDTN- BMPR2_Hsap_STKR2 ------------------------------------------------------TGNRLV ALK7_Hsap_STKR1 ------------------------------------------------------DSILN- ALK4_Hsap_STKR1 ------------------------------------------------------DAVTD- tkv_Dmel_STKR1 ------------------------------------------------------NSELD- put_Dmel_STKR2 ------------------------------------------------------QPGKP- SAX_Dmel_STKR1 ------------------------------------------------------SHVTG- wit_Dmel_STKR2 ------------------------------------------------------FGSKYE BABO_Dmel_STKR1 ------------------------------------------------------VEKND- TGFBR1_Mmus_STKR1 ------------------------------------------------------DSATD- TGFBR2_Mmus_STKR2 ------------------------------------------------------DPTLS- sma-6_Cele_STKR1 ------------------------------------------------------QNDK-I ALK2_Hsap_STKR1 ------------------------------------------------------SQSTN- ALK1_Hsap_STKR1 ------------------------------------------------------SQGSD- ACTR2B_Hsap_STKR2 ------------------------------------------------------EPGKP- ACTR2_Hsap_STKR2 ------------------------------------------------------EAGKS- TGFbR1_Spur_STKR1 ------------------------------------------------------DSVTD- ALK2_Spur_STKR1 ------------------------------------------------------TQRED- BMPR1_Spur_STKR1 LAYSAANGLAHLHTEICGMQGKPAIAHRDVKSSNIMVRKNGTCMIADMSLAARFLSEGN- TGFbRII_Spur_STKR2 ------------------------------------------------------DPQSS- ACTR2_Spur_STKR2 ------------------------------------------------------EAGKN- BMPR2_Spur_STKR2 ------------------------------------------------------CGSSVV AqueK680_Aque_STKR1 ------------------------------------------------------L----- AqueK681_Aque_STKR1 ------------------------------------------------------SED--F AqueK682_Aque_STKR1 ------------------------------------------------------SESGD- AqueK683_Aque_STKR2 ------------------------------------------------------NGGI-- AqueK684_Aque_STKR2 ------------------------------------------------------DGV-D- AqueK685_Aque_STKR2 ------------------------------------------------------DPAAD- AqueK686_Aque_STKR2 ------------------------------------------------------DPAAD- TGFbR2_Hsap_STKR2 ------V-DD-LANSGQVGTARYMAPEVLESRMNLENVE-SFKQTDVYSMALVLWEMTSR TGFbR1_Hsap_STKR1 ------T-ID-IAPNHRVGTKRYMAPEVLDDSINMKHFE-SFKRADIYAMGLVFWEIARR MISR2_Hsap_STKR2 PAWTPTQPQG-PAAIMEAGTQRYMAPELLDKTLDLQDWGMALRRADIYSLALLLWEILSR MISR2_Mmus_STKR2 PALAPTQPRG-PAAILEAGTQRYMAPELLDKTLDLQDWGTALQRADVYSLALLLWEILSR BMPR2_Mmus_STKR2 R---PGE-ED-NAAISEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEVFMR BMPR1B_Mmus_STKR1 ------E-VD-IPPNTRVGTKRYMPPEVLDESLNRNHFQ-SYIMADMYSFGLILWEIARR BMPR1A_Mmus_STKR1 ------E-VD-IPLNTRVGTKRYMAPEVLDESLNKNHFQ-PYIMADIYSFGLIIWEMARR ALK7_Mmus_STKR1 ------T-ID-IPQNPKVGTKRYMAPEMLDDTMNLSIFE-SFKRADIYSVGLVYWEIARR ALK4_Mmus_STKR1 ------T-ID-IAPNQRVGTKRYMAPEVLDETINMKHFD-SFKCADIYALGLVYWEIARR ALK2_Mmus_STKR1 ------Q-LD-VGNNPRVGTKRYMAPEVLDETIQVDCFD-SYKRVDIWAFGLVLWEVARR ALK1_Mmus_STKR1 ------Y-LD-IGNNPRVGTKRYMAPEVLDEHIRTDCFE-SYKWTDIWAFGLVLWEIARR ACTR2B_Mmus_STKR2 ------P-GD---THGQVGTRRYMAPEVLEGAINFQR-D-AFLRIDMYAMGLVLWELVSR ACTR2_Mmus_STKR2 ------A-GD---THGQVGTRRYMAPEVLEGAINFQR-D-AFLRIDMYAMGLVLWELASR daf-4_Cele_STKR2 ------Q-SD---LLGQVGTKRYMSPEMLEGATEFTP-T-AFKAMDVYSMGLVMWEVISR daf-1_Cele_STKR1 ------D-II-ANENYKCGTVRYLAPEILNSTMQFTVFE-SYQCADVYSFSLVMWETLCR BMPR1A_Hsap_STKR1 ------E-VD-VPLNTRVGTKRYMAPEVLDESLNKNHFQ-PYIMADIYSFGLIIWEMARR BMPR1B_Hsap_STKR1 ------E-VD-IPPNTRVGTKRYMPPEVLDESLNRNHFQ-SYIMADMYSFGLILWEVARR BMPR2_Hsap_STKR2 R---PGE-ED-NAAISEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMR ALK7_Hsap_STKR1 ------T-ID-IPQNPKVGTKRYMAPEMLDDTMNVNIFE-SFKRADIYSVGLVYWEIARR ALK4_Hsap_STKR1 ------T-ID-IAPNQRVGTKRYMAPEVLDETINMKHFD-SFKCADIYALGLVYWEIARR tkv_Dmel_STKR1 ------V-IH-IAQNPRVGTRRYMAPEVLSQQLDPKQFE-EFKRADMYSVGLVLWEMTRR put_Dmel_STKR2 ------C-GD---THGQVGTRRYMAPEVLEGAINFNR-D-AFLRIDVYACGLVLWEMVSR SAX_Dmel_STKR1 ------Q-LD-LGNNPKVGTKRYMAPEVLDESIDLECFE-ALRRTDIYAFGLVLWEVCRR wit_Dmel_STKR2 YKGEVAM-AE-TKSINEVGTLRYMAPELLEGAVNLRDCETSLKQMDVYALGLVLWEVATR BABO_Dmel_STKR1 ------S-VD-IPSTHRVGTKRYMAPEVLDESMNDQHFD-SYKRADVYAFGLILWEIARR TGFBR1_Mmus_STKR1 ------T-ID-IAPNHRVGTKRYMAPEVLDDSINMKHFE-SFKRADIYAMGLVFWEIARR TGFBR2_Mmus_STKR2 ------V-DD-LANSGQVGTARYMAPEVLESRMNLENVE-SFKQTDVYSMALVLWEMTSR sma-6_Cele_STKR1 --------LP-EKFNVQVGTKRYMAPELISNKLNPKDFS-QFKMADIYSMALVMWEVAIR ALK2_Hsap_STKR1 ------Q-LD-VGNNPRVGTKRYMAPEVLDETIQVDCFD-SYKRVDIWAFGLVLWEVARR ALK1_Hsap_STKR1 ------Y-LD-IGNNPRVGTKRYMAPEVLDEQIRTDCFE-SYKWTDIWAFGLVLWEIARR ACTR2B_Hsap_STKR2 ------P-GD---THGQVGTRRYMAPEVLEGAINFQR-D-AFLRIDMYAMGLVLWELVSR ACTR2_Hsap_STKR2 ------A-GD---THGQVGTRRYMAPEVLEGAINFQR-D-AFLRIDMYAMGLVLWELASR TGFbR1_Spur_STKR1 ------T-VD-IFPNNRIGTKRYMAPEVLDDTINMNHFD-SFKRADVYSFGLVLWEIGRR ALK2_Spur_STKR1 ------N-ID-MGTNTRVGTKRYMAPELLEETMDVRCFE-SFKRVDVYAFGLVMWEIARR BMPR1_Spur_STKR1 ------E-ID-LGQNTRLGTTRYLPPEVLDNVLMSNTFD-AFKMADMYSFGMVLWEIARR TGFbRII_Spur_STKR2 ------T-DH-LANSGQVGTPRYMSPEALECKVNLQDIE-SFKQMDTYALALILWEITSR ACTR2_Spur_STKR2 ------P-GD---THGQVGTRRYMAPEVLEGAIQFKR-D-AFLRIDMYAFGLVLWELVTR BMPR2_Spur_STKR2 G---EGD-GD-NSTITDVGTVRYMSPEVLDGAVNLRDCECALKQVDVYALGLVVWEIAMR AqueK680_Aque_STKR1 ---------N-FNNNVQQGTKRYMPPEVIKGTIDVHSFE-SFLRADIYSFGLVMWEVCTR AqueK681_Aque_STKR1 ------Q-S---FICLKQGTNRYMAPEILNETIDVKDFV-SFLRADVYSFALVAWEVFNR AqueK682_Aque_STKR1 ------G-VDQIPANKLSGTKRYMSPEILNESLDYGRFI-CYAQSDIYSFSLIIWEIFNC AqueK683_Aque_STKR2 --------IA-VGRDSEVIILGICLPEVLQGFQSF-TIT-SLTNSDIYSLGLCIWEVLNC AqueK684_Aque_STKR2 ------M-IL-SEAKGQVGTSRYMAPEILEGAVRFNQ-E-AFLKIDIYAFGLILWEMLSC AqueK685_Aque_STKR2 ------D-RK-LAVSGQVGTYRYMSPEALDARVNLRDSE-SFKQIDVYAMSLVLWEVCMR AqueK686_Aque_STKR2 ------D-RK-LAVSGQVGTYRYMSPEALDARVNLRDIE-SFKQIDMYALSLVLWEVCMR ** :. * :: .: ** TGFbR2_Hsap_STKR2 CNAV-------------------------------------------------GEV---K TGFbR1_Hsap_STKR1 CSIG-------------------------------------------------GIH---E MISR2_Hsap_STKR2 CPDL--RP--------------------------------------------DSSP---P MISR2_Mmus_STKR2 CSDL--RP--------------------------------------------DHRP---P BMPR2_Mmus_STKR2 CTDL--FP--------------------------------------------GESV---P BMPR1B_Mmus_STKR1 CVSG-------------------------------------------------GIV---E BMPR1A_Mmus_STKR1 CITG-------------------------------------------------GIV---E ALK7_Mmus_STKR1 CSVG-------------------------------------------------GVV---E ALK4_Mmus_STKR1 CNSG-------------------------------------------------GVH---E ALK2_Mmus_STKR1 MVSN-------------------------------------------------GIV---E ALK1_Mmus_STKR1 TIIN-------------------------------------------------GIV---E ACTR2B_Mmus_STKR2 CKAA-D-----------------------------------------------GPV---D ACTR2_Mmus_STKR2 CTAA-D-----------------------------------------------GPV---D daf-4_Cele_STKR2 TKLHQT-----------------------------------------------DEP---P daf-1_Cele_STKR1 CED--G-----------------------------------------------DVLPREA BMPR1A_Hsap_STKR1 CITG-------------------------------------------------GIV---E BMPR1B_Hsap_STKR1 CVSG-------------------------------------------------GIV---E BMPR2_Hsap_STKR2 CTDL--FP--------------------------------------------GESV---P ALK7_Hsap_STKR1 CSVG-------------------------------------------------GIV---E ALK4_Hsap_STKR1 CNSG-------------------------------------------------GVH---E tkv_Dmel_STKR1 CYTPVSGTK-------------------------------------------TTTC---E put_Dmel_STKR2 CDF--A-----------------------------------------------GPV---G SAX_Dmel_STKR1 TISC-------------------------------------------------GIA---E wit_Dmel_STKR2 CSDFY-AP--------------------------------------------GQAT---P BABO_Dmel_STKR1 CNMG-------------------------------------------------MIY---D TGFBR1_Mmus_STKR1 CSIG-------------------------------------------------GIH---E TGFBR2_Mmus_STKR2 CNAV-------------------------------------------------GEV---K sma-6_Cele_STKR1 VEVN--TCEEVLTVDETSPDHSASSGIGESVSSSGNISRMHLQKTNVEGHSTSLKA---K ALK2_Hsap_STKR1 MVSN-------------------------------------------------GIV---E ALK1_Hsap_STKR1 TIVN-------------------------------------------------GIV---E ACTR2B_Hsap_STKR2 CKAA-D-----------------------------------------------GPV---D ACTR2_Hsap_STKR2 CTAA-D-----------------------------------------------GPV---D TGFbR1_Spur_STKR1 CQVF-------------------------------------------------GIY---E ALK2_Spur_STKR1 CEVG-------------------------------------------------GMV---A BMPR1_Spur_STKR1 CVTR-------------------------------------------------GIV---E TGFbRII_Spur_STKR2 CTLL-------------------------------------------------KDI---N ACTR2_Spur_STKR2 CTVQ-D-----------------------------------------------GPV---P BMPR2_Spur_STKR2 CKDL--YP--------------------------------------------RDEM---G AqueK680_Aque_STKR1 CHLE-------------------------------------------------GPL---A AqueK681_Aque_STKR1 CNIEQG-----------------------------------------------GIA---R AqueK682_Aque_STKR1 CEID-------------------------------------------------GV---PR AqueK683_Aque_STKR2 CQIT-------------------------------------------------G-----N AqueK684_Aque_STKR2 CDLN-------------------------------------------------NITS-NP AqueK685_Aque_STKR2 YQSN-------------------------------------------------DV-P-VP AqueK686_Aque_STKR2 YQSD-------------------------------------------------DV-P-VP TGFbR2_Hsap_STKR2 DYEPPFGSKVRE-HPCVESMKDNVLRDRGRPEIPSFWLNHQ-GIQMVCETLTECWDHDPE TGFbR1_Hsap_STKR1 DYQLPYYDLVPS-DPSVEEMRKVVCEQKLRPNIPNRWQSCE-ALRVMAKIMRECWYANGA MISR2_Hsap_STKR2 PFQLAYEAELGN-TPTSDELWALAVQERRRPYIPSTWRCFATDPDGLRELLEDCWDADPE MISR2_Mmus_STKR2 PFQLAYEAELGS-NPSACELWALAVEERKRPNIPSTWSCSATDPRGLRELLEDCWDADPE BMPR2_Mmus_STKR2 DYQMAFQTEVGN-HPTFEDMQVLVSREKQRPKFPEAWKENSLAVRSLKETIEDCWDQDAE BMPR1B_Mmus_STKR1 EYQLPYHDLVPS-DPSYEDMREIVCMKKLRPSFPNRWSSDE-CLRQMGKLMTECWAQNPA BMPR1A_Mmus_STKR1 EYQLPYYNMVPS-DPSYEDMREVVCVKRLRPIVSNRWNSDE-CLRAVLKLMSECWAHNPA ALK7_Mmus_STKR1 EYQLPYYDMVPS-DPSIEEMRKVVCDQKLRPNLPNQWQSCE-ALRVMGRIMRECWYANGA ALK4_Mmus_STKR1 DYQLPYYDLVPS-DPSIEEMRKVVCDQKLRPNVPNWWQSYE-ALRVMGKMMRECWYANGA ALK2_Mmus_STKR1 DYKPPFYDVVPN-DPSFEDMRKVVCVDQQRPNIPNRWFSDP-TLTSLAKLMKECWYQNPS ALK1_Mmus_STKR1 DYRPPFYDMVPN-DPSFEDMKKVVCVDQQTPTIPNRLAADP-VLSGLAQMMRECWYPNPS ACTR2B_Mmus_STKR2 EYMLPFEEEIGQ-HPSLEELQEVVVHKKMRPTIKDHWLKHP-GLAQLCVTIEECWDHDAE ACTR2_Mmus_STKR2 EYMLPFEEEIGQ-HPSLEDMQEVVVHKKKRPVLRDYWQKHA-GMAMLCETIEECWDHDAE daf-4_Cele_STKR2 NYQMPFQ-VIGF-DPTIGLMRNYVVSKKERPQWRDEIIKHE-YMSLLKKVTEEMWDPEAC daf-1_Cele_STKR1 ATVIPYIEWTDR-DPQDAQMFDVVCTRRLRPTENPLWKDHP-EMKHIMEIIKTCWNGNPS BMPR1A_Hsap_STKR1 EYQLPYYNMVPS-DPSYEDMREVVCVKRLRPIVSNRWNSDE-CLRAVLKLMSECWAHNPA BMPR1B_Hsap_STKR1 EYQLPYHDLVPS-DPSYEDMREIVCIKKLRPSFPNRWSSDE-CLRQMGKLMTECWAHNPA BMPR2_Hsap_STKR2 EYQMAFQTEVGN-HPTFEDMQVLVSREKQRPKFPEAWKENSLAVRSLKETIEDCWDQDAE ALK7_Hsap_STKR1 EYQLPYYDMVPS-DPSIEEMRKVVCDQKFRPSIPNQWQSCE-ALRVMGRIMRECWYANGA ALK4_Hsap_STKR1 EYQLPYYDLVPS-DPSIEEMRKVVCDQKLRPNIPNWWQSYE-ALRVMGKMMRECWYANGA tkv_Dmel_STKR1 DYALPYHDVVPS-DPTFEDMHAVVCVKGFRPPIPSRWQEDD-VLATVSKIMQECWHPNPT put_Dmel_STKR2 EFQLPFEAELGL-RPSLDEVQESVVMKKLRPRLLNSWRAHP-GLNVFCDTMEECWDHDAE SAX_Dmel_STKR1 EYKVPFYDVVPM-DPSFEDMRKVVCIDNYRPSIPNRWSSDS-LMTGMSKLMKECWHQNPD wit_Dmel_STKR2 PYKAPYEQEVGS-HPSFDQMQALVVRHKARPLFPTGWGGGA-AAKVVRDTCEDCWDHDAD BABO_Dmel_STKR1 EYQLPYYDVVQP-DPSIEEMKKVVCIEKCRPNIPNRWHASD-VLHNMAKVMKECWYPNPV TGFBR1_Mmus_STKR1 DYQLPYYDLVPS-DPSVEEMRKVVCEQKLRPNIPNRWQSCE-ALRVMAKIMRECWYANGA TGFBR2_Mmus_STKR2 DYEPPFGSKVRE-HPCVESMKDSVLRDRGRPEIPSFWLNHQ-GIQIVCETLTECWDHDPE sma-6_Cele_STKR1 QHVPPFDGIVHN-DPNFDEMNDVICVRRIRPPPDLAWKNVP-ALNELSKLMEDSWHSIPH ALK2_Hsap_STKR1 DYKPPFYDVVPN-DPSFEDMRKVVCVDQQRPNIPNRWFSDP-TLTSLAKLMKECWYQNPS ALK1_Hsap_STKR1 DYRPPFYDVVPN-DPSFEDMKKVVCVDQQTPTIPNRLAADP-VLSGLAQMMRECWYPNPS ACTR2B_Hsap_STKR2 EYMLPFEEEIGQ-HPSLEELQEVVVHKKMRPTIKDHWLKHP-GLAQLCVTIEECWDHDAE ACTR2_Hsap_STKR2 EYMLPFEEEIGQ-HPSLEDMQEVVVHKKKRPVLRDYWQKHA-GMAMLCETIEECWDHDAE TGFbR1_Spur_STKR1 EFCLPYHPWVPM-DPPIDDMRRIVCIEKRRPPVPNRWNSHK-IMESYAKVMKECWYQNGA ALK2_Spur_STKR1 DYKPPFFEYVPS-DPSFDDMRKVACIEKLRPNIPNRWTNNT-VLTSMAKLMKECWCPTAS BMPR1_Spur_STKR1 ECQLPFYDAVPM-DPSIQDMMRVVVIERRRPDIPNRWSGDD-ILRTISKVMSECWNQNPA TGFbRII_Spur_STKR2 EYELPFSRSLGDRRASLEMMKTLVVLRRERPPITDEWLRNP-GLTIIKNTVVDCWDEDPE ACTR2_Spur_STKR2 EYRLPFEEELGQ-GTSLEDMQEWVVVKRKRPVISDHWLKHR-GLELLCETIEECWDQDAE BMPR2_Spur_STKR2 NYQMPFEEQVGL-HPTFEDMQILVSRERKRPQFPDAWKQNSQALRSLKETIEDCWDHDAE AqueK680_Aque_STKR1 DYALPFQSQVPP-DPTLDDMTEFIVGKEVIPEIPETWSNNE-LLRGMSRVMYECWYHQPT AqueK681_Aque_STKR1 EYQLPYSDHLPN-NSSIEDCRRVVVEEGTRPV-TSEWSKTR-FLEKLSVTIKELWAERGS AqueK682_Aque_STKR1 SYQLPYCEWVPT-DPDIDQMKQCVCVNNRRPTIPDSWTESE-TLSPIAKLLDSSWATQAS AqueK683_Aque_STKR2 SYTPPFHEVSDS-DISMDIMRSMIVEQGIVPALPAVFDEIK-EFSSVRNTVSECFDLEPE AqueK684_Aque_STKR2 SYYPPFDGWVSA-NPSIDEMKRIVVEEKKRPPIPQKFQTNL-KYSFIADIIVECWDDDAD AqueK685_Aque_STKR2 PYQSPFFDMVGE-KPTLDQMKEIVVINKQRPLLPEKWNNDK-NLKRIIKLIVEGWDEDPE AqueK686_Aque_STKR2 PYQSPFFDMVGE-KPTLEQMKEIVVNANKRPGFTGVWYSDK-NLKRIIKLIKEGWDEDPE .: * : TGFbR2_Hsap_STKR2 ARLTAQCVAERFSE-LEHLDRLSGR----------------------------------- TGFbR1_Hsap_STKR1 ARLTALRIKKTLSQ-LSQQE---------------------------------------- MISR2_Hsap_STKR2 ARLTAECVQQRLAA-LAHPQESHPF--PESCPR--------------------------- MISR2_Mmus_STKR2 ARLTAECVQQRLAA-LAYPHGASSF--PES------------------------------ BMPR2_Mmus_STKR2 ARLTAQCAEERMAE-LMMIWERNKSVSPTVNPMSTAMQNER-------NLSHNRRVPKIG BMPR1B_Mmus_STKR1 SRLTALRVKKTLAK-MSESQ---------------------------------------- BMPR1A_Mmus_STKR1 SRLTALRIKKTLAK-MVESQ---------------------------------------- ALK7_Mmus_STKR1 ARLTALRVKKTISQ-LCVKE---------------------------------------- ALK4_Mmus_STKR1 ARLTALRIKKTLSQ-LSVQE---------------------------------------- ALK2_Mmus_STKR1 ARLTALRIKKTLTK-IDNSLD--------------------------------------- ALK1_Mmus_STKR1 ARLTALRIKKTLQK-LSHNPE--------------------------------------- ACTR2B_Mmus_STKR2 ARLSAGCVEERVSL-IRRSVNGTTS----------------------------------- ACTR2_Mmus_STKR2 ARLSAGCVGERITQ-MQRLTNIITT----------------------------------- daf-4_Cele_STKR2 ARITAGCAFARVWNHIMSSPDSS--EG---Y----------------------------- daf-1_Cele_STKR1 ARFTSYICRKRMDE-RQQLLLDKK------------------------------------ BMPR1A_Hsap_STKR1 SRLTALRIKKTLAK-MVESQ---------------------------------------- BMPR1B_Hsap_STKR1 SRLTALRVKKTLAK-MSESQ---------------------------------------- BMPR2_Hsap_STKR2 ARLTAQCAEERMAE-LMMIWERNKSVSPTVNPMSTAMQNER-------NLSHNRRVPKIG ALK7_Hsap_STKR1 ARLTALRIKKTISQ-LCVKE---------------------------------------- ALK4_Hsap_STKR1 ARLTALRIKKTLSQ-LSVQE---------------------------------------- tkv_Dmel_STKR1 VRLTALRVKKTLGR-LETDCLID------------------------------------- put_Dmel_STKR2 ARLSSSCVMERFAQ-LNKYPSTQL------------------------------------ SAX_Dmel_STKR1 VRLPALRIKKTIHK-LASADEKIR------------------------------------ wit_Dmel_STKR2 ARLTSLCAEERMQE-MSTLRPRAQA-QPSS-PLL----NTN-------N---------LV BABO_Dmel_STKR1 ARLTALRIKKTLAS-ISVED---------------------------------------- TGFBR1_Mmus_STKR1 ARLTALRIKKTLSQ-LSQQE---------------------------------------- TGFBR2_Mmus_STKR2 ARLTAQCVAERFSE-LEHPERLSGR----------------------------------- sma-6_Cele_STKR1 FRHSALKLKKEMAE-LIKNPDRQNQS---------------------------------- ALK2_Hsap_STKR1 ARLTALRIKKTLTK-IDNSLD--------------------------------------- ALK1_Hsap_STKR1 ARLTALRIKKTLQK-ISNSPE--------------------------------------- ACTR2B_Hsap_STKR2 ARLSAGCVEERVSL-IRRSVNGTTS----------------------------------- ACTR2_Hsap_STKR2 ARLSAGCVGERITQ-MQRLTNIITT----------------------------------- TGFbR1_Spur_STKR1 ARLTALRIKKTLAG-LMGPSEPEV------------------------------------ ALK2_Spur_STKR1 ARHTSLRVKKTLMK-ISETCPKLT------------------------------------ BMPR1_Spur_STKR1 ARVTSLRVKKTLGK-LQEN----------------------------------------- TGFbRII_Spur_STKR2 ARLTASCVEARFQE-LILWHEGEPH----------------------------------- ACTR2_Spur_STKR2 ARLSAGCVEERIAQ-FSHSHMNGHMNG---H----------------------------- BMPR2_Spur_STKR2 ARLTALCVEERIIE-LMVLWDKHRMISPTINPTTQGN---AIPTHTMNEYTTRPTDIISR AqueK680_Aque_STKR1 ARPSAYYIRKKVDK-IAEMCEVR------------------------------------- AqueK681_Aque_STKR1 ERPSIELLRKKIEK-EARTYDDCN------------------------------------ AqueK682_Aque_STKR1 SRISALRISKILKG-IDFK----------------------------------------- AqueK683_Aque_STKR2 ARPNSHILKNLFSK-LLHDLLEKKSS---------------------------------- AqueK684_Aque_STKR2 GRPAASLISRRLSE-FQTAGYTASPHL---PPLSNKSSK--------------------- AqueK685_Aque_STKR2 ARLTAANIKIQLES-LVGMRPKPPPSS---T--S-------------------------- AqueK686_Aque_STKR2 ARLTAANIKIQLES-LIGMRPKLDSLS---SPLS-------------------------- * . TGFbR2_Hsap_STKR2 ------------------------------------------------------------ TGFbR1_Hsap_STKR1 ------------------------------------------------------------ MISR2_Hsap_STKR2 ------------------------------------------------------------ MISR2_Mmus_STKR2 ------------------------------------------------------------ BMPR2_Mmus_STKR2 PYP-------------------------DYSSSSYIEDSIHHTDSIVKNISSEHSMSST- BMPR1B_Mmus_STKR1 ------------------------------------------------------------ BMPR1A_Mmus_STKR1 ------------------------------------------------------------ ALK7_Mmus_STKR1 ------------------------------------------------------------ ALK4_Mmus_STKR1 ------------------------------------------------------------ ALK2_Mmus_STKR1 ------------------------------------------------------------ ALK1_Mmus_STKR1 ------------------------------------------------------------ ACTR2B_Mmus_STKR2 ------------------------------------------------------------ ACTR2_Mmus_STKR2 ------------------------------------------------------------ daf-4_Cele_STKR2 -----------------------------------------------------HSGS--- daf-1_Cele_STKR1 ------------------------------------------------------------ BMPR1A_Hsap_STKR1 ------------------------------------------------------------ BMPR1B_Hsap_STKR1 ------------------------------------------------------------ BMPR2_Hsap_STKR2 PYP-------------------------DYSSSSYIEDSIHHTDSIVKNISSEHSMSST- ALK7_Hsap_STKR1 ------------------------------------------------------------ ALK4_Hsap_STKR1 ------------------------------------------------------------ tkv_Dmel_STKR1 ------------------------------------------------------------ put_Dmel_STKR2 ------------------------------------------------------------ SAX_Dmel_STKR1 ------------------------------------------------------------ wit_Dmel_STKR2 AS-------------------------------PTAEQGINIIATTTTAAAVHHQMSSDT BABO_Dmel_STKR1 ------------------------------------------------------------ TGFBR1_Mmus_STKR1 ------------------------------------------------------------ TGFBR2_Mmus_STKR2 ------------------------------------------------------------ sma-6_Cele_STKR1 ------------------------------------------------------------ ALK2_Hsap_STKR1 ------------------------------------------------------------ ALK1_Hsap_STKR1 ------------------------------------------------------------ ACTR2B_Hsap_STKR2 ------------------------------------------------------------ ACTR2_Hsap_STKR2 ------------------------------------------------------------ TGFbR1_Spur_STKR1 ------------------------------------------------------------ ALK2_Spur_STKR1 ------------------------------------------------------------ BMPR1_Spur_STKR1 ------------------------------------------------------------ TGFbRII_Spur_STKR2 ------------------------------------------------------------ ACTR2_Spur_STKR2 -----------------------------------------------------HPVS--- BMPR2_Spur_STKR2 EYPGIARLADGTMIAVRSNGQPVLGAASE----------TSGTA---SDTKNHHGLHSS- AqueK680_Aque_STKR1 ------------------------------------------------------------ AqueK681_Aque_STKR1 ------------------------------------------------------------ AqueK682_Aque_STKR1 ------------------------------------------------------------ AqueK683_Aque_STKR2 ------------------------------------------------------------ AqueK684_Aque_STKR2 -------------------------------------------------ESGFHSLSGQ- AqueK685_Aque_STKR2 ------------------------------------------------------------ AqueK686_Aque_STKR2 ------------------------------------------------------------ TGFbR2_Hsap_STKR2 ------------------------------------------------------------ TGFbR1_Hsap_STKR1 ------------------------------------------------------------ MISR2_Hsap_STKR2 ------------------------------------------------------------ MISR2_Mmus_STKR2 ------------------------------------------------------------ BMPR2_Mmus_STKR2 ------------PLTIG-----------------------------------------EK BMPR1B_Mmus_STKR1 ------------------------------------------------------------ BMPR1A_Mmus_STKR1 ------------------------------------------------------------ ALK7_Mmus_STKR1 ------------------------------------------------------------ ALK4_Mmus_STKR1 ------------------------------------------------------------ ALK2_Mmus_STKR1 ------------------------------------------------------------ ALK1_Mmus_STKR1 ------------------------------------------------------------ ACTR2B_Mmus_STKR2 ------------------------------------------------------------ ACTR2_Mmus_STKR2 ------------------------------------------------------------ daf-4_Cele_STKR2 --------------------------------------SMKNRGVDDVEQSEKPEGIEEM daf-1_Cele_STKR1 ------------------------------------------------------------ BMPR1A_Hsap_STKR1 ------------------------------------------------------------ BMPR1B_Hsap_STKR1 ------------------------------------------------------------ BMPR2_Hsap_STKR2 ------------PLTIG-----------------------------------------EK ALK7_Hsap_STKR1 ------------------------------------------------------------ ALK4_Hsap_STKR1 ------------------------------------------------------------ tkv_Dmel_STKR1 ------------------------------------------------------------ put_Dmel_STKR2 ------------------------------------------------------------ SAX_Dmel_STKR1 ------------------------------------------------------------ wit_Dmel_STKR2 TGLIQPPPNQQIPLAAL-----------------------------------------ER BABO_Dmel_STKR1 ------------------------------------------------------------ TGFBR1_Mmus_STKR1 ------------------------------------------------------------ TGFBR2_Mmus_STKR2 ------------------------------------------------------------ sma-6_Cele_STKR1 ------------------------------------------------------------ ALK2_Hsap_STKR1 ------------------------------------------------------------ ALK1_Hsap_STKR1 ------------------------------------------------------------ ACTR2B_Hsap_STKR2 ------------------------------------------------------------ ACTR2_Hsap_STKR2 ------------------------------------------------------------ TGFbR1_Spur_STKR1 ------------------------------------------------------------ ALK2_Spur_STKR1 ------------------------------------------------------------ BMPR1_Spur_STKR1 ------------------------------------------------------------ TGFbRII_Spur_STKR2 ------------------------------------------------------------ ACTR2_Spur_STKR2 --------------------------------------P-------------TPLIMQ-- BMPR2_Spur_STKR2 ---------VSSGLEKN-----------------------------------------E- AqueK680_Aque_STKR1 ------------------------------------------------------------ AqueK681_Aque_STKR1 ------------------------------------------------------------ AqueK682_Aque_STKR1 ------------------------------------------------------------ AqueK683_Aque_STKR2 ------------------------------------------------------------ AqueK684_Aque_STKR2 ------------PLLSSSGVNNDALATDYNINTPLPPTP-------------TPSSPS-- AqueK685_Aque_STKR2 ----------------------------------------------------QPDGRN-- AqueK686_Aque_STKR2 --------------------------------------P-------------PPEGEG-- TGFbR2_Hsap_STKR2 ------------------------------------------------------------ TGFbR1_Hsap_STKR1 ------------------------------------------------------------ MISR2_Hsap_STKR2 ------------------------------------------------------------ MISR2_Mmus_STKR2 ------------------------------------------------------------ BMPR2_Mmus_STKR2 NRNSINYERQQA---QARIPSPETSVTSLSTNTTTTNTTGLTPSTGMTTISEMPYPDET- BMPR1B_Mmus_STKR1 ------------------------------------------------------------ BMPR1A_Mmus_STKR1 ------------------------------------------------------------ ALK7_Mmus_STKR1 ------------------------------------------------------------ ALK4_Mmus_STKR1 ------------------------------------------------------------ ALK2_Mmus_STKR1 ------------------------------------------------------------ ALK1_Mmus_STKR1 ------------------------------------------------------------ ACTR2B_Mmus_STKR2 ------------------------------------------------------------ ACTR2_Mmus_STKR2 ------------------------------------------------------------ daf-4_Cele_STKR2 QHYHASSPSK-------------------------------------------------- daf-1_Cele_STKR1 ------------------------------------------------------------ BMPR1A_Hsap_STKR1 ------------------------------------------------------------ BMPR1B_Hsap_STKR1 ------------------------------------------------------------ BMPR2_Hsap_STKR2 NRNSINYERQQA---QARIPSPETSVTSLSTNTTTTNTTGLTPSTGMTTISEMPYPDET- ALK7_Hsap_STKR1 ------------------------------------------------------------ ALK4_Hsap_STKR1 ------------------------------------------------------------ tkv_Dmel_STKR1 ------------------------------------------------------------ put_Dmel_STKR2 ------------------------------------------------------------ SAX_Dmel_STKR1 ------------------------------------------------------------ wit_Dmel_STKR2 EKNHLSYPQQQLQPYQGRNPCQERNLAP-------------------------------- BABO_Dmel_STKR1 ------------------------------------------------------------ TGFBR1_Mmus_STKR1 ------------------------------------------------------------ TGFBR2_Mmus_STKR2 ------------------------------------------------------------ sma-6_Cele_STKR1 ------------------------------------------------------------ ALK2_Hsap_STKR1 ------------------------------------------------------------ ALK1_Hsap_STKR1 ------------------------------------------------------------ ACTR2B_Hsap_STKR2 ------------------------------------------------------------ ACTR2_Hsap_STKR2 ------------------------------------------------------------ TGFbR1_Spur_STKR1 ------------------------------------------------------------ ALK2_Spur_STKR1 ------------------------------------------------------------ BMPR1_Spur_STKR1 ------------------------------------------------------------ TGFbRII_Spur_STKR2 ------------------------------------------------------------ ACTR2_Spur_STKR2 -TMHNSTSF--------------------------------------------------- BMPR2_Spur_STKR2 ---------------RLRLMSPGTISTSLSSQ-SDLNLIDLTASAPPVDPKNLHHSDDSI AqueK680_Aque_STKR1 ------------------------------------------------------------ AqueK681_Aque_STKR1 ------------------------------------------------------------ AqueK682_Aque_STKR1 ------------------------------------------------------------ AqueK683_Aque_STKR2 ------------------------------------------------------------ AqueK684_Aque_STKR2 ---------ITLSPT--------------------------------------------- AqueK685_Aque_STKR2 ---------NFLSPI--------------------------------------------- AqueK686_Aque_STKR2 ---------VFLSPV--------------------------------------------- TGFbR2_Hsap_STKR2 ------------------------------------------------------------ TGFbR1_Hsap_STKR1 ------------------------------------------------------------ MISR2_Hsap_STKR2 --------------GCPPLC----PED--------------------------------- MISR2_Mmus_STKR2 ----------------PQGC----PEN--------------------------------- BMPR2_Mmus_STKR2 HLHATNVA---QSIGPTPVCLQLTEEDLETNKLDPKEVDKNLKESSDENLMEH------- BMPR1B_Mmus_STKR1 ------------------------------------------------------------ BMPR1A_Mmus_STKR1 ------------------------------------------------------------ ALK7_Mmus_STKR1 ------------------------------------------------------------ ALK4_Mmus_STKR1 ------------------------------------------------------------ ALK2_Mmus_STKR1 ------------------------------------------------------------ ALK1_Mmus_STKR1 ------------------------------------------------------------ ACTR2B_Mmus_STKR2 ------------------------------------------------------------ ACTR2_Mmus_STKR2 ------------------------------------------------------------ daf-4_Cele_STKR2 ------------------------------------------------------------ daf-1_Cele_STKR1 ------------------------------------------------------------ BMPR1A_Hsap_STKR1 ------------------------------------------------------------ BMPR1B_Hsap_STKR1 ------------------------------------------------------------ BMPR2_Hsap_STKR2 NLHTTNVA---QSIGPTPVCLQLTEEDLETNKLDPKEVDKNLKESSDENLMEH------- ALK7_Hsap_STKR1 ------------------------------------------------------------ ALK4_Hsap_STKR1 ------------------------------------------------------------ tkv_Dmel_STKR1 ------------------------------------------------------------ put_Dmel_STKR2 ------------------------------------------------------------ SAX_Dmel_STKR1 ------------------------------------------------------------ wit_Dmel_STKR2 ----------------------------LTMRTPPVLVERSKKHSFQTQPQEN------- BABO_Dmel_STKR1 ------------------------------------------------------------ TGFBR1_Mmus_STKR1 ------------------------------------------------------------ TGFBR2_Mmus_STKR2 ------------------------------------------------------------ sma-6_Cele_STKR1 ------------------------------------------------------------ ALK2_Hsap_STKR1 ------------------------------------------------------------ ALK1_Hsap_STKR1 ------------------------------------------------------------ ACTR2B_Hsap_STKR2 ------------------------------------------------------------ ACTR2_Hsap_STKR2 ------------------------------------------------------------ TGFbR1_Spur_STKR1 ------------------------------------------------------------ ALK2_Spur_STKR1 ------------------------------------------------------------ BMPR1_Spur_STKR1 ------------------------------------------------------------ TGFbRII_Spur_STKR2 ------------------------------------------------------------ ACTR2_Spur_STKR2 ------------------------------------------------------------ BMPR2_Spur_STKR2 ERYTTDLKYGPQQSGP-KYCDQYGFSEPSTSPSRPLVVNEMRAGLSKDQMTDNLSHGMGK AqueK680_Aque_STKR1 ------------------------------------------------------------ AqueK681_Aque_STKR1 ------------------------------------------------------------ AqueK682_Aque_STKR1 ------------------------------------------------------------ AqueK683_Aque_STKR2 ------------------------------------------------------------ AqueK684_Aque_STKR2 ------------------------------------------------EIKSH------- AqueK685_Aque_STKR2 ------------------------------------------------LE---------- AqueK686_Aque_STKR2 ------------------------------------------------SE---------- TGFbR2_Hsap_STKR2 ------------------------------------------------------------ TGFbR1_Hsap_STKR1 ------------------------------------------------------------ MISR2_Hsap_STKR2 ------------------------------------------------------------ MISR2_Mmus_STKR2 ------------------------------------------------------------ BMPR2_Mmus_STKR2 ---------SLKQFSGPDPLSSTSSSLLYPLIKLAVEVTGQQDF-------------TQA BMPR1B_Mmus_STKR1 ------------------------------------------------------------ BMPR1A_Mmus_STKR1 ------------------------------------------------------------ ALK7_Mmus_STKR1 ------------------------------------------------------------ ALK4_Mmus_STKR1 ------------------------------------------------------------ ALK2_Mmus_STKR1 ------------------------------------------------------------ ALK1_Mmus_STKR1 ------------------------------------------------------------ ACTR2B_Mmus_STKR2 ------------------------------------------------------------ ACTR2_Mmus_STKR2 ------------------------------------------------------------ daf-4_Cele_STKR2 -----------RQHPSPNPFF--------------------------------------- daf-1_Cele_STKR1 ------------------------------------------------------------ BMPR1A_Hsap_STKR1 ------------------------------------------------------------ BMPR1B_Hsap_STKR1 ------------------------------------------------------------ BMPR2_Hsap_STKR2 ---------SLKQFSGPDPLSSTSSSLLYPLIKLAVEATGQQDF-------------TQT ALK7_Hsap_STKR1 ------------------------------------------------------------ ALK4_Hsap_STKR1 ------------------------------------------------------------ tkv_Dmel_STKR1 ------------------------------------------------------------ put_Dmel_STKR2 ------------------------------------------------------------ SAX_Dmel_STKR1 ------------------------------------------------------------ wit_Dmel_STKR2 ---------SLS--------------------CLEHDVSVEELIASHQHQQQKNTIVSTG BABO_Dmel_STKR1 ------------------------------------------------------------ TGFBR1_Mmus_STKR1 ------------------------------------------------------------ TGFBR2_Mmus_STKR2 ------------------------------------------------------------ sma-6_Cele_STKR1 ------------------------------------------------------------ ALK2_Hsap_STKR1 ------------------------------------------------------------ ALK1_Hsap_STKR1 ------------------------------------------------------------ ACTR2B_Hsap_STKR2 ------------------------------------------------------------ ACTR2_Hsap_STKR2 ------------------------------------------------------------ TGFbR1_Spur_STKR1 ------------------------------------------------------------ ALK2_Spur_STKR1 ------------------------------------------------------------ BMPR1_Spur_STKR1 ------------------------------------------------------------ TGFbRII_Spur_STKR2 ------------------------------------------------------------ ACTR2_Spur_STKR2 ------------------------------------------------------------ BMPR2_Spur_STKR2 LKNKSSSMPSWNHINGVDPRSRGANQ-PVNMAKLDTNLHRQQARSASPKQSNQNGYEASG AqueK680_Aque_STKR1 ------------------------------------------------------------ AqueK681_Aque_STKR1 ------------------------------------------------------------ AqueK682_Aque_STKR1 ------------------------------------------------------------ AqueK683_Aque_STKR2 ------------------------------------------------------------ AqueK684_Aque_STKR2 ---------TVHDFSSSSTSS--------------------------------------- AqueK685_Aque_STKR2 ------------------SSE--------------------------------------- AqueK686_Aque_STKR2 ------------------TSH--------------------------------------- TGFbR2_Hsap_STKR2 ------------------------------------------------------------ TGFbR1_Hsap_STKR1 ------------------------------------------------------------ MISR2_Hsap_STKR2 -----C------------------------------------------------------ MISR2_Mmus_STKR2 -----C------------------------------------------------------ BMPR2_Mmus_STKR2 ANGQAC------------------------------------------------------ BMPR1B_Mmus_STKR1 ------------------------------------------------------------ BMPR1A_Mmus_STKR1 ------------------------------------------------------------ ALK7_Mmus_STKR1 ------------------------------------------------------------ ALK4_Mmus_STKR1 ------------------------------------------------------------ ALK2_Mmus_STKR1 ------------------------------------------------------------ ALK1_Mmus_STKR1 ------------------------------------------------------------ ACTR2B_Mmus_STKR2 ------------------------------------------------------------ ACTR2_Mmus_STKR2 ------------------------------------------------------------ daf-4_Cele_STKR2 ---DSCPPPPPIPVILENGG---ILQPDNAEPEPE------------------------- daf-1_Cele_STKR1 ------------------------------------------------------------ BMPR1A_Hsap_STKR1 ------------------------------------------------------------ BMPR1B_Hsap_STKR1 ------------------------------------------------------------ BMPR2_Hsap_STKR2 ANGQAC------------------------------------------------------ ALK7_Hsap_STKR1 ------------------------------------------------------------ ALK4_Hsap_STKR1 ------------------------------------------------------------ tkv_Dmel_STKR1 ------------------------------------------------------------ put_Dmel_STKR2 ------------------------------------------------------------ SAX_Dmel_STKR1 ------------------------------------------------------------ wit_Dmel_STKR2 GNGNSC------------------------------------------------------ BABO_Dmel_STKR1 ------------------------------------------------------------ TGFBR1_Mmus_STKR1 ------------------------------------------------------------ TGFBR2_Mmus_STKR2 ------------------------------------------------------------ sma-6_Cele_STKR1 ------------------------------------------------------------ ALK2_Hsap_STKR1 ------------------------------------------------------------ ALK1_Hsap_STKR1 ------------------------------------------------------------ ACTR2B_Hsap_STKR2 ------------------------------------------------------------ ACTR2_Hsap_STKR2 ------------------------------------------------------------ TGFbR1_Spur_STKR1 ------------------------------------------------------------ ALK2_Spur_STKR1 ------------------------------------------------------------ BMPR1_Spur_STKR1 ------------------------------------------------------------ TGFbRII_Spur_STKR2 ------------------------------------------------------------ ACTR2_Spur_STKR2 ------------------------------------------------------------ BMPR2_Spur_STKR2 SSGASS------------------------------------------------------ AqueK680_Aque_STKR1 ------------------------------------------------------------ AqueK681_Aque_STKR1 ------------------------------------------------------------ AqueK682_Aque_STKR1 ------------------------------------------------------------ AqueK683_Aque_STKR2 ------------------------------------------------------------ AqueK684_Aque_STKR2 ---SSCPTRSSLPIHFSPAKKSDTS----------------------------------- AqueK685_Aque_STKR2 ---SSCKKY-RLSSS-----FSESSGNAVIFSNP---SSKLSGRFSVDH-TNNASSHRT- AqueK686_Aque_STKR2 ---SSCKKV-HISAS-----FSGSTNA---MLSPAAAPHSFHGRFSLDHGGHNPVTVSMI TGFbR2_Hsap_STKR2 ------------------------------------------------------------ TGFbR1_Hsap_STKR1 ------------------------------------------------------------ MISR2_Hsap_STKR2 ------------------------------------------------------------ MISR2_Mmus_STKR2 ------------------------------------------------------------ BMPR2_Mmus_STKR2 ------------------------------------------------------------ BMPR1B_Mmus_STKR1 ------------------------------------------------------------ BMPR1A_Mmus_STKR1 ------------------------------------------------------------ ALK7_Mmus_STKR1 ------------------------------------------------------------ ALK4_Mmus_STKR1 ------------------------------------------------------------ ALK2_Mmus_STKR1 ------------------------------------------------------------ ALK1_Mmus_STKR1 ------------------------------------------------------------ ACTR2B_Mmus_STKR2 ------------------------------------------------------------ ACTR2_Mmus_STKR2 ------------------------------------------------------------ daf-4_Cele_STKR2 -ELPDLPI---------------VEK--IY-----DIA---------------------T daf-1_Cele_STKR1 ------------------------------------------------------------ BMPR1A_Hsap_STKR1 ------------------------------------------------------------ BMPR1B_Hsap_STKR1 ------------------------------------------------------------ BMPR2_Hsap_STKR2 ------------------------------------------------------------ ALK7_Hsap_STKR1 ------------------------------------------------------------ ALK4_Hsap_STKR1 ------------------------------------------------------------ tkv_Dmel_STKR1 ------------------------------------------------------------ put_Dmel_STKR2 ------------------------------------------------------------ SAX_Dmel_STKR1 ------------------------------------------------------------ wit_Dmel_STKR2 ------------------------------------------------------------ BABO_Dmel_STKR1 ------------------------------------------------------------ TGFBR1_Mmus_STKR1 ------------------------------------------------------------ TGFBR2_Mmus_STKR2 ------------------------------------------------------------ sma-6_Cele_STKR1 ------------------------------------------------------------ ALK2_Hsap_STKR1 ------------------------------------------------------------ ALK1_Hsap_STKR1 ------------------------------------------------------------ ACTR2B_Hsap_STKR2 ------------------------------------------------------------ ACTR2_Hsap_STKR2 ------------------------------------------------------------ TGFbR1_Spur_STKR1 ------------------------------------------------------------ ALK2_Spur_STKR1 ------------------------------------------------------------ BMPR1_Spur_STKR1 ------------------------------------------------------------ TGFbRII_Spur_STKR2 ------------------------------------------------------------ ACTR2_Spur_STKR2 ------------------------------------------------------------ BMPR2_Spur_STKR2 ------------------------------------------------------------ AqueK680_Aque_STKR1 ------------------------------------------------------------ AqueK681_Aque_STKR1 ------------------------------------------------------------ AqueK682_Aque_STKR1 ------------------------------------------------------------ AqueK683_Aque_STKR2 ------------------------------------------------------------ AqueK684_Aque_STKR2 ----DP---------------RSRKA--VT-----PLRSNPG-KPTDLGSGNISGGDLFS AqueK685_Aque_STKR2 -ILNDLR---RYRDGIG--LSN--NISTTTTDSTQ---------PNG----AYTGGG--S AqueK686_Aque_STKR2 LSLSDVQVQYRPPDTVATANSE--SIT---VPALIPQ-SEPTTAPQL---------A--S TGFbR2_Hsap_STKR2 ------S----------------------------------------------------- TGFbR1_Hsap_STKR1 ------------------------------------------------------------ MISR2_Hsap_STKR2 --------T--S--------IPAPTILPCRPQ----------RSA--------------- MISR2_Mmus_STKR2 --------L--S--------APASAVFPCRPQ----------QSS--------------- BMPR2_Mmus_STKR2 --------LIPDVPPAQIYPLPKQQNLPKRPT----------SLPLN-TKNSTKEPRLKF BMPR1B_Mmus_STKR1 ------------------------------------------------------------ BMPR1A_Mmus_STKR1 ------------------------------------------------------------ ALK7_Mmus_STKR1 ------------------------------------------------------------ ALK4_Mmus_STKR1 ------------------------------------------------------------ ALK2_Mmus_STKR1 ------------------------------------------------------------ ALK1_Mmus_STKR1 ------------------------------------------------------------ ACTR2B_Mmus_STKR2 ------D----------------------------------------------------- ACTR2_Mmus_STKR2 ------E----------------------------------------------------- daf-4_Cele_STKR2 NMLFSRE----------------------------------------------------- daf-1_Cele_STKR1 ------------------------------------------------------------ BMPR1A_Hsap_STKR1 ------------------------------------------------------------ BMPR1B_Hsap_STKR1 ------------------------------------------------------------ BMPR2_Hsap_STKR2 --------LIPDVLPTQIYPLPKQQNLPKRPT----------SLPLN-TKNSTKEPRLKF ALK7_Hsap_STKR1 ------------------------------------------------------------ ALK4_Hsap_STKR1 ------------------------------------------------------------ tkv_Dmel_STKR1 ------------------------------------------------------------ put_Dmel_STKR2 ------------------------------------------------------------ SAX_Dmel_STKR1 ------------------------------------------------------------ wit_Dmel_STKR2 --------LGQG--------FPKQQNTDQKLRGWHGVRALIHKKL--------------F BABO_Dmel_STKR1 ------------------------------------------------------------ TGFBR1_Mmus_STKR1 ------------------------------------------------------------ TGFBR2_Mmus_STKR2 ------S----------------------------------------------------- sma-6_Cele_STKR1 ------Q----------------------------------------------------- ALK2_Hsap_STKR1 ------------------------------------------------------------ ALK1_Hsap_STKR1 ------------------------------------------------------------ ACTR2B_Hsap_STKR2 ------D----------------------------------------------------- ACTR2_Hsap_STKR2 ------E----------------------------------------------------- TGFbR1_Spur_STKR1 ------------------------------------------------------------ ALK2_Spur_STKR1 ------------------------------------------------------------ BMPR1_Spur_STKR1 ------------------------------------------------------------ TGFbRII_Spur_STKR2 ------A----------------------------------------------------- ACTR2_Spur_STKR2 ------E----------------------------------------------------- BMPR2_Spur_STKR2 --------EGA--------GPSSIPNMNIRPN----------SLPLQSTHRGSKKKLMAV AqueK680_Aque_STKR1 ------------------------------------------------------------ AqueK681_Aque_STKR1 ------------------------------------------------------------ AqueK682_Aque_STKR1 ------------------------------------------------------------ AqueK683_Aque_STKR2 ------S----------------------------------------------------- AqueK684_Aque_STKR2 -----QYDLSSSSGAGDVVSPLCD------------------------------------ AqueK685_Aque_STKR2 -----R-----------------D------------------------------------ AqueK686_Aque_STKR2 -----N-----------------N------------------------------------ TGFbR2_Hsap_STKR2 -------------------------C---------------------------------- TGFbR1_Hsap_STKR1 ------------------------------------------------------------ MISR2_Hsap_STKR2 -------------------------C---------------------------------- MISR2_Mmus_STKR2 -------------------------C---------------------------------- BMPR2_Mmus_STKR2 GNKHKSNL-KQVETGVAKMNTI-----------------------NAAEPHVVTVTMNGV BMPR1B_Mmus_STKR1 ------------------------------------------------------------ BMPR1A_Mmus_STKR1 ------------------------------------------------------------ ALK7_Mmus_STKR1 ------------------------------------------------------------ ALK4_Mmus_STKR1 ------------------------------------------------------------ ALK2_Mmus_STKR1 ------------------------------------------------------------ ALK1_Mmus_STKR1 ------------------------------------------------------------ ACTR2B_Mmus_STKR2 -------------------------C---------------------------------- ACTR2_Mmus_STKR2 -------------------------D---------------------------------- daf-4_Cele_STKR2 -------------------------E---------------------------------- daf-1_Cele_STKR1 ------------------------------------------------------------ BMPR1A_Hsap_STKR1 ------------------------------------------------------------ BMPR1B_Hsap_STKR1 ------------------------------------------------------------ BMPR2_Hsap_STKR2 GSKHKSNL-KQVETGVAKMNTI-----------------------NAAEPHVVTVTMNGV ALK7_Hsap_STKR1 ------------------------------------------------------------ ALK4_Hsap_STKR1 ------------------------------------------------------------ tkv_Dmel_STKR1 ------------------------------------------------------------ put_Dmel_STKR2 ------------------------------------------------------------ SAX_Dmel_STKR1 ------------------------------------------------------------ wit_Dmel_STKR2 RKEHAEELCRQLQLGEEKSNLV-----------------------TAL------------ BABO_Dmel_STKR1 ------------------------------------------------------------ TGFBR1_Mmus_STKR1 ------------------------------------------------------------ TGFBR2_Mmus_STKR2 -------------------------C---------------------------------- sma-6_Cele_STKR1 -------------------------R---------------------------------- ALK2_Hsap_STKR1 ------------------------------------------------------------ ALK1_Hsap_STKR1 ------------------------------------------------------------ ACTR2B_Hsap_STKR2 -------------------------C---------------------------------- ACTR2_Hsap_STKR2 -------------------------D---------------------------------- TGFbR1_Spur_STKR1 ------------------------------------------------------------ ALK2_Spur_STKR1 ------------------------------------------------------------ BMPR1_Spur_STKR1 ------------------------------------------------------------ TGFbRII_Spur_STKR2 -------------------------Q---------------------------------- ACTR2_Spur_STKR2 -------------------------N---------------------------------- BMPR2_Spur_STKR2 YNPNTGPT-TKVQTGIAKMDSVAPSCHQVKMAANTHKQQPTHNAVEKLR----------- AqueK680_Aque_STKR1 ------------------------------------------------------------ AqueK681_Aque_STKR1 ------------------------------------------------------------ AqueK682_Aque_STKR1 ------------------------------------------------------------ AqueK683_Aque_STKR2 -------------------------P---------------------------------- AqueK684_Aque_STKR2 -------------------------D---------------------------------- AqueK685_Aque_STKR2 -------------------------E---------------------------------- AqueK686_Aque_STKR2 -------------------------E---------------------------------- TGFbR2_Hsap_STKR2 ------------------------------------------------------------ TGFbR1_Hsap_STKR1 ------------------------------------------------------------ MISR2_Hsap_STKR2 ------------------------------------------------------------ MISR2_Mmus_STKR2 ------------------------------------------------------------ BMPR2_Mmus_STKR2 AGRSHNVNSHAATTQYAN----------------------------------GAVPAGQA BMPR1B_Mmus_STKR1 ------------------------------------------------------------ BMPR1A_Mmus_STKR1 ------------------------------------------------------------ ALK7_Mmus_STKR1 ------------------------------------------------------------ ALK4_Mmus_STKR1 ------------------------------------------------------------ ALK2_Mmus_STKR1 ------------------------------------------------------------ ALK1_Mmus_STKR1 ------------------------------------------------------------ ACTR2B_Mmus_STKR2 ------------------------------------------------------------ ACTR2_Mmus_STKR2 ------------------------------------------------------------ daf-4_Cele_STKR2 ------------------------------------------------------------ daf-1_Cele_STKR1 ------------------------------------------------------------ BMPR1A_Hsap_STKR1 ------------------------------------------------------------ BMPR1B_Hsap_STKR1 ------------------------------------------------------------ BMPR2_Hsap_STKR2 AGRNHSVNSHAATTQYAN----------------------------------GTVLSGQT ALK7_Hsap_STKR1 ------------------------------------------------------------ ALK4_Hsap_STKR1 ------------------------------------------------------------ tkv_Dmel_STKR1 ------------------------------------------------------------ put_Dmel_STKR2 ------------------------------------------------------------ SAX_Dmel_STKR1 ------------------------------------------------------------ wit_Dmel_STKR2 ------------------------------------------------------------ BABO_Dmel_STKR1 ------------------------------------------------------------ TGFBR1_Mmus_STKR1 ------------------------------------------------------------ TGFBR2_Mmus_STKR2 ------------------------------------------------------------ sma-6_Cele_STKR1 ------------------------------------------------------------ ALK2_Hsap_STKR1 ------------------------------------------------------------ ALK1_Hsap_STKR1 ------------------------------------------------------------ ACTR2B_Hsap_STKR2 ------------------------------------------------------------ ACTR2_Hsap_STKR2 ------------------------------------------------------------ TGFbR1_Spur_STKR1 ------------------------------------------------------------ ALK2_Spur_STKR1 ------------------------------------------------------------ BMPR1_Spur_STKR1 ------------------------------------------------------------ TGFbRII_Spur_STKR2 ------------------------------------------------------------ ACTR2_Spur_STKR2 ------------------------------------------------------------ BMPR2_Spur_STKR2 -----------------NGNVGNLEPEADRPHSWACDSSSGSDRSHEIDRKNGNACSGSA AqueK680_Aque_STKR1 ------------------------------------------------------------ AqueK681_Aque_STKR1 ------------------------------------------------------------ AqueK682_Aque_STKR1 ------------------------------------------------------------ AqueK683_Aque_STKR2 ------------------------------------------------------------ AqueK684_Aque_STKR2 ------------------------------------------------------------ AqueK685_Aque_STKR2 ------------------------------------------------------------ AqueK686_Aque_STKR2 ------------------------------------------------------------ TGFbR2_Hsap_STKR2 ------------------------------------------------------------ TGFbR1_Hsap_STKR1 ------------------------------------------------------------ MISR2_Hsap_STKR2 ---------------------HF---SVQQGP--CS------------------------ MISR2_Mmus_STKR2 ---------------------LL---SVQQGP--GS------------------------ BMPR2_Mmus_STKR2 ANIVAHRSQEMLQNQFIGEDTRL---NINSSP--DEHEPL--LRREQQAGHDEGVLDRLV BMPR1B_Mmus_STKR1 ------------------------------------------------------------ BMPR1A_Mmus_STKR1 ------------------------------------------------------------ ALK7_Mmus_STKR1 ------------------------------------------------------------ ALK4_Mmus_STKR1 ------------------------------------------------------------ ALK2_Mmus_STKR1 ------------------------------------------------------------ ALK1_Mmus_STKR1 ------------------------------------------------------------ ACTR2B_Mmus_STKR2 ---------------------L-------------------------------------- ACTR2_Mmus_STKR2 ---------------------I-------------------------------------- daf-4_Cele_STKR2 ---------------------L------------------------------D----LM- daf-1_Cele_STKR1 ------------------------------------------------------------ BMPR1A_Hsap_STKR1 ------------------------------------------------------------ BMPR1B_Hsap_STKR1 ------------------------------------------------------------ BMPR2_Hsap_STKR2 TNIVTHRAQEMLQNQFIGEDTRL---NINSSP--DEHEPL--LRREQQAGHDEGVLDRLV ALK7_Hsap_STKR1 ------------------------------------------------------------ ALK4_Hsap_STKR1 ------------------------------------------------------------ tkv_Dmel_STKR1 ------------------------------------------------------------ put_Dmel_STKR2 ------------------------------------------------------------ SAX_Dmel_STKR1 ------------------------------------------------------------ wit_Dmel_STKR2 ----------------------RRPNNLDLNPRLDKPPPDQLRSAEQRMGTPAHIVPRSL BABO_Dmel_STKR1 ------------------------------------------------------------ TGFBR1_Mmus_STKR1 ------------------------------------------------------------ TGFBR2_Mmus_STKR2 ------------------------------------------------------------ sma-6_Cele_STKR1 ---------------------K-------------------------------------- ALK2_Hsap_STKR1 ------------------------------------------------------------ ALK1_Hsap_STKR1 ------------------------------------------------------------ ACTR2B_Hsap_STKR2 ---------------------L-------------------------------------- ACTR2_Hsap_STKR2 ---------------------I-------------------------------------- TGFbR1_Spur_STKR1 ------------------------------------------------------------ ALK2_Spur_STKR1 ------------------------------------------------------------ BMPR1_Spur_STKR1 ------------------------------------------------------------ TGFbRII_Spur_STKR2 ------------------------------------------------------------ ACTR2_Spur_STKR2 ---------------------T-----------------------------------GN- BMPR2_Spur_STKR2 SCIAKGDNGKRKVTPFRLLTEKL---SIHKGK--DKKE---------------------- AqueK680_Aque_STKR1 ------------------------------------------------------------ AqueK681_Aque_STKR1 ------------------------------------------------------------ AqueK682_Aque_STKR1 ------------------------------------------------------------ AqueK683_Aque_STKR2 ---------------------I-------------------------------------- AqueK684_Aque_STKR2 ---------------------V------------------------------RKFSLQL- AqueK685_Aque_STKR2 ---------------------V------------------------------S----SS- AqueK686_Aque_STKR2 ---------------------V------------------------------S----NG- TGFbR2_Hsap_STKR2 ------------------------------------------------------------ TGFbR1_Hsap_STKR1 ------------------------------------------------------------ MISR2_Hsap_STKR2 ------------------------------------------------------RNP--- MISR2_Mmus_STKR2 ------------------------------------------------------RSPD-- BMPR2_Mmus_STKR2 DRRERPLEGGRTNSNNNNSNPCSEQDI-----LTQ-------------GVTSTAADPGPS BMPR1B_Mmus_STKR1 ------------------------------------------------------------ BMPR1A_Mmus_STKR1 ------------------------------------------------------------ ALK7_Mmus_STKR1 ------------------------------------------------------------ ALK4_Mmus_STKR1 ------------------------------------------------------------ ALK2_Mmus_STKR1 ------------------------------------------------------------ ALK1_Mmus_STKR1 ------------------------------------------------------------ ACTR2B_Mmus_STKR2 --------------------------V-----S--------------------------- ACTR2_Mmus_STKR2 --------------------------V-----T--------------------------- daf-4_Cele_STKR2 ---------------------NAQRQV-----E--------------------------- daf-1_Cele_STKR1 ------------------------------------------------------------ BMPR1A_Hsap_STKR1 ------------------------------------------------------------ BMPR1B_Hsap_STKR1 ------------------------------------------------------------ BMPR2_Hsap_STKR2 DRRERPLEGGRTNSNNNNSNPCSEQDV-----LAQ-------------GVPSTAADPGPS ALK7_Hsap_STKR1 ------------------------------------------------------------ ALK4_Hsap_STKR1 ------------------------------------------------------------ tkv_Dmel_STKR1 ------------------------------------------------------------ put_Dmel_STKR2 ------------------------------------------------------------ SAX_Dmel_STKR1 ------------------------------------------------------------ wit_Dmel_STKR2 SSSLIKHINGTT-NNNSIQSHGSELQT-----LTRPASKRRPGHLRTNSLMATT-GQGPP BABO_Dmel_STKR1 ------------------------------------------------------------ TGFBR1_Mmus_STKR1 ------------------------------------------------------------ TGFBR2_Mmus_STKR2 ------------------------------------------------------------ sma-6_Cele_STKR1 --------------------------V-----E--------------------------- ALK2_Hsap_STKR1 ------------------------------------------------------------ ALK1_Hsap_STKR1 ------------------------------------------------------------ ACTR2B_Hsap_STKR2 --------------------------V-----S--------------------------- ACTR2_Hsap_STKR2 --------------------------V-----T--------------------------- TGFbR1_Spur_STKR1 ------------------------------------------------------------ ALK2_Spur_STKR1 ------------------------------------------------------------ BMPR1_Spur_STKR1 ------------------------------------------------------------ TGFbRII_Spur_STKR2 ------------------------------------------------------------ ACTR2_Spur_STKR2 ---------------------TE---S-----T--------------------------- BMPR2_Spur_STKR2 ------------------------------------------------------------ AqueK680_Aque_STKR1 ------------------------------------------------------------ AqueK681_Aque_STKR1 ------------------------------------------------------------ AqueK682_Aque_STKR1 ------------------------------------------------------------ AqueK683_Aque_STKR2 --------------------------VEEEELE--------------------------- AqueK684_Aque_STKR2 ---------------------DYTEDF-----K--------------------------- AqueK685_Aque_STKR2 ---------------------ESQDEV-----N--------------------------- AqueK686_Aque_STKR2 ---------------------GSQDEV-----N--------------------------- TGFbR2_Hsap_STKR2 ------------------------------------------------------------ TGFbR1_Hsap_STKR1 ------------------------------------------------------------ MISR2_Hsap_STKR2 ------------------------------------------------------------ MISR2_Mmus_STKR2 ------------------------------------------------------------ BMPR2_Mmus_STKR2 KPRRAQRPNSLDLSATNILDGSSIQIGESTQDGKSGSGEK----------------I-KR BMPR1B_Mmus_STKR1 ------------------------------------------------------------ BMPR1A_Mmus_STKR1 ------------------------------------------------------------ ALK7_Mmus_STKR1 ------------------------------------------------------------ ALK4_Mmus_STKR1 ------------------------------------------------------------ ALK2_Mmus_STKR1 ------------------------------------------------------------ ALK1_Mmus_STKR1 ------------------------------------------------------------ ACTR2B_Mmus_STKR2 ---------------------------------------L----------------V--- ACTR2_Mmus_STKR2 ---------------------------------------V----------------V--- daf-4_Cele_STKR2 -----------------Y---EA------------GA--D----------------T--- daf-1_Cele_STKR1 ------------------------------------------------------------ BMPR1A_Hsap_STKR1 ------------------------------------------------------------ BMPR1B_Hsap_STKR1 ------------------------------------------------------------ BMPR2_Hsap_STKR2 KPRRAQRPNSLDLSATNVLDGSSIQIGESTQDGKSGSGEK----------------I-KK ALK7_Hsap_STKR1 ------------------------------------------------------------ ALK4_Hsap_STKR1 ------------------------------------------------------------ tkv_Dmel_STKR1 ------------------------------------------------------------ put_Dmel_STKR2 ---------------------------------------L----------------I--- SAX_Dmel_STKR1 ------------------------------------------------------------ wit_Dmel_STKR2 TEQQMRRQHSLEV-------------FREVFSG-RGSSER----------------L-RD BABO_Dmel_STKR1 ------------------------------------------------------------ TGFBR1_Mmus_STKR1 ------------------------------------------------------------ TGFBR2_Mmus_STKR2 ------------------------------------------------------------ sma-6_Cele_STKR1 ---------------------------------------F----------------Q--- ALK2_Hsap_STKR1 ------------------------------------------------------------ ALK1_Hsap_STKR1 ------------------------------------------------------------ ACTR2B_Hsap_STKR2 ---------------------------------------L----------------V--- ACTR2_Hsap_STKR2 ---------------------------------------V----------------V--- TGFbR1_Spur_STKR1 ------------------------------------------------------------ ALK2_Spur_STKR1 ------------------------------------------------------------ BMPR1_Spur_STKR1 ------------------------------------------------------------ TGFbRII_Spur_STKR2 ------------------------------------------------------------ ACTR2_Spur_STKR2 ---------------------------------------D----------------I--- BMPR2_Spur_STKR2 -PK-----------------------------------------------------D-Q- AqueK680_Aque_STKR1 ------------------------------------------------------------ AqueK681_Aque_STKR1 ------------------------------------------------------------ AqueK682_Aque_STKR1 ------------------------------------------------------------ AqueK683_Aque_STKR2 ---------------------------------------AFTGTEQTEELPSSEVVLPL- AqueK684_Aque_STKR2 ------------------------------------------------------------ AqueK685_Aque_STKR2 -----------------V------------------------------------------ AqueK686_Aque_STKR2 -----------------VIDATT------------GQ----------------------- TGFbR2_Hsap_STKR2 ------------------------------------------------------------ TGFbR1_Hsap_STKR1 ------------------------------------------------------------ MISR2_Hsap_STKR2 ------------------------------------------------------------ MISR2_Mmus_STKR2 ------------------------------------------------------------ BMPR2_Mmus_STKR2 ---RVKTPY----SLKRWRPSTWVISTEPLDC-----------EVNNNGSDRAVHSKSST BMPR1B_Mmus_STKR1 ------------------------------------------------------------ BMPR1A_Mmus_STKR1 ------------------------------------------------------------ ALK7_Mmus_STKR1 ------------------------------------------------------------ ALK4_Mmus_STKR1 ------------------------------------------------------------ ALK2_Mmus_STKR1 ------------------------------------------------------------ ALK1_Mmus_STKR1 ------------------------------------------------------------ ACTR2B_Mmus_STKR2 ------------------------------------------------------------ ACTR2_Mmus_STKR2 ------------------------------------------------------------ daf-4_Cele_STKR2 ------------------------------------------------------------ daf-1_Cele_STKR1 ------------------------------------------------------------ BMPR1A_Hsap_STKR1 ------------------------------------------------------------ BMPR1B_Hsap_STKR1 ------------------------------------------------------------ BMPR2_Hsap_STKR2 ---RVKTPY----SLKRWRPSTWVISTESLDC-----------EVNNNGSNRAVHSKSST ALK7_Hsap_STKR1 ------------------------------------------------------------ ALK4_Hsap_STKR1 ------------------------------------------------------------ tkv_Dmel_STKR1 ------------------------------------------------------------ put_Dmel_STKR2 ------------------------------------------------------------ SAX_Dmel_STKR1 ------------------------------------------------------------ wit_Dmel_STKR2 PSERVKTPGDVPPSVRKARASK-------------------------------------- BABO_Dmel_STKR1 ------------------------------------------------------------ TGFBR1_Mmus_STKR1 ------------------------------------------------------------ TGFBR2_Mmus_STKR2 ------------------------------------------------------------ sma-6_Cele_STKR1 ------------------------------------------------------------ ALK2_Hsap_STKR1 ------------------------------------------------------------ ALK1_Hsap_STKR1 ------------------------------------------------------------ ACTR2B_Hsap_STKR2 ------------------------------------------------------------ ACTR2_Hsap_STKR2 ------------------------------------------------------------ TGFbR1_Spur_STKR1 ------------------------------------------------------------ ALK2_Spur_STKR1 ------------------------------------------------------------ BMPR1_Spur_STKR1 ------------------------------------------------------------ TGFbRII_Spur_STKR2 ------------------------------------------------------------ ACTR2_Spur_STKR2 ------------------------------------------------------------ BMPR2_Spur_STKR2 -----------------------------TDCNGVNNRNPVELNVNN------------- AqueK680_Aque_STKR1 ------------------------------------------------------------ AqueK681_Aque_STKR1 ------------------------------------------------------------ AqueK682_Aque_STKR1 ------------------------------------------------------------ AqueK683_Aque_STKR2 ------------------------------------------------------------ AqueK684_Aque_STKR2 ------------------------------------------------------------ AqueK685_Aque_STKR2 ------------------------------------------------------------ AqueK686_Aque_STKR2 ------------------------------------------------------------ TGFbR2_Hsap_STKR2 -----------------------------------------------------SE----- TGFbR1_Hsap_STKR1 ------------------------------------------------------------ MISR2_Hsap_STKR2 ------------------------------------------------------------ MISR2_Mmus_STKR2 ------------------------------------------------------------ BMPR2_Mmus_STKR2 AVYLAEGG------------------------------------------T--AT----- BMPR1B_Mmus_STKR1 ------------------------------------------------------------ BMPR1A_Mmus_STKR1 ------------------------------------------------------------ ALK7_Mmus_STKR1 ------------------------------------------------------------ ALK4_Mmus_STKR1 ------------------------------------------------------------ ALK2_Mmus_STKR1 ------------------------------------------------------------ ALK1_Mmus_STKR1 ------------------------------------------------------------ ACTR2B_Mmus_STKR2 --------------------------------------------------T--SV----- ACTR2_Mmus_STKR2 --------------------------------------------------T--MV----- daf-4_Cele_STKR2 --------------------------------------------------R--AS----- daf-1_Cele_STKR1 ------------------------------------------------------A---KA BMPR1A_Hsap_STKR1 ------------------------------------------------------------ BMPR1B_Hsap_STKR1 ------------------------------------------------------------ BMPR2_Hsap_STKR2 AVYLAEGG------------------------------------------T--AT----- ALK7_Hsap_STKR1 ------------------------------------------------------------ ALK4_Hsap_STKR1 ------------------------------------------------------------ tkv_Dmel_STKR1 ------------------------------------------------------------ put_Dmel_STKR2 --------------------------------------------------K--NH----- SAX_Dmel_STKR1 ------------------------------------------------------------ wit_Dmel_STKR2 ------------------------------------------------------T----- BABO_Dmel_STKR1 ------------------------------------------------------------ TGFBR1_Mmus_STKR1 ------------------------------------------------------------ TGFBR2_Mmus_STKR2 -----------------------------------------------------SQ----- sma-6_Cele_STKR1 --------------------------------------------------Q--QD----- ALK2_Hsap_STKR1 ------------------------------------------------------------ ALK1_Hsap_STKR1 ------------------------------------------------------------ ACTR2B_Hsap_STKR2 --------------------------------------------------T--SV----- ACTR2_Hsap_STKR2 --------------------------------------------------T--MV----- TGFbR1_Spur_STKR1 ---------------------------------------------------------LLP ALK2_Spur_STKR1 ------------------------------------------------------------ BMPR1_Spur_STKR1 ------------------------------------------------------------ TGFbRII_Spur_STKR2 -----------------------------------------------------SF----- ACTR2_Spur_STKR2 --------------------------------------------------A--LY----- BMPR2_Spur_STKR2 -----NARAIAPQTLANGSDNDSVACSDLSNGHAGVSLNGDAYPLNSKLVN--GS----- AqueK680_Aque_STKR1 ------------------------------------------------------------ AqueK681_Aque_STKR1 ------------------------------------------------------N--LST AqueK682_Aque_STKR1 ------------------------------------------------------------ AqueK683_Aque_STKR2 --------------------------------------------------TQHSQTGT-- AqueK684_Aque_STKR2 ------------------------------------------------------------ AqueK685_Aque_STKR2 ------------------------------------------------------------ AqueK686_Aque_STKR2 ------------------------------------------------------------ TGFbR2_Hsap_STKR2 ------------------------------------------------------------ TGFbR1_Hsap_STKR1 ------------------------------------------------------------ MISR2_Hsap_STKR2 ------------------------------------------------------------ MISR2_Mmus_STKR2 ------------------------------------------------------------ BMPR2_Mmus_STKR2 ------------------------------------------------------------ BMPR1B_Mmus_STKR1 ------------------------------------------------------------ BMPR1A_Mmus_STKR1 ------------------------------------------------------------ ALK7_Mmus_STKR1 ------------------------------------------------------------ ALK4_Mmus_STKR1 ------------------------------------------------------------ ALK2_Mmus_STKR1 ------------------------------------------------------------ ALK1_Mmus_STKR1 ------------------------------------------------------------ ACTR2B_Mmus_STKR2 ------------------------------------------------------------ ACTR2_Mmus_STKR2 ------------------------------------------------------------ daf-4_Cele_STKR2 ------------------------------------------------------------ daf-1_Cele_STKR1 VAQT----------------A--------------------------------------- BMPR1A_Hsap_STKR1 ------------------------------------------------------------ BMPR1B_Hsap_STKR1 ------------------------------------------------------------ BMPR2_Hsap_STKR2 ------------------------------------------------------------ ALK7_Hsap_STKR1 ------------------------------------------------------------ ALK4_Hsap_STKR1 ------------------------------------------------------------ tkv_Dmel_STKR1 ------------------------------------------------------------ put_Dmel_STKR2 ------------------------------------------------------------ SAX_Dmel_STKR1 ------------------------------------------------------------ wit_Dmel_STKR2 ------------------------------------------------------------ BABO_Dmel_STKR1 ------------------------------------------------------------ TGFBR1_Mmus_STKR1 ------------------------------------------------------------ TGFBR2_Mmus_STKR2 ------------------------------------------------------------ sma-6_Cele_STKR1 ------------------------------------------------------------ ALK2_Hsap_STKR1 ------------------------------------------------------------ ALK1_Hsap_STKR1 ------------------------------------------------------------ ACTR2B_Hsap_STKR2 ------------------------------------------------------------ ACTR2_Hsap_STKR2 ------------------------------------------------------------ TGFbR1_Spur_STKR1 PAN--------------------------------------------------------- ALK2_Spur_STKR1 ------------------------------------------------------------ BMPR1_Spur_STKR1 ------------------------------------------------------------ TGFbRII_Spur_STKR2 ------------------------------------------------------------ ACTR2_Spur_STKR2 ------------------------------------------------------------ BMPR2_Spur_STKR2 ------------------------------------------------------------ AqueK680_Aque_STKR1 ------------------------------------------------------------ AqueK681_Aque_STKR1 LIDIVQATIFIVVFRMLRLLAKIPLFGIILKSLIRVLVLLIPFLLLGYLFYFEFAIVGMA AqueK682_Aque_STKR1 ------------------------------------------------------------ AqueK683_Aque_STKR2 ------------------------------------------------------------ AqueK684_Aque_STKR2 ------------------------------------------------------------ AqueK685_Aque_STKR2 ------------------------------------------------------------ AqueK686_Aque_STKR2 ------------------------------------------------------------ TGFbR2_Hsap_STKR2 ------------------------------------------------------------ TGFbR1_Hsap_STKR1 ------------------------------------------------------------ MISR2_Hsap_STKR2 ------------------------------------------------------------ MISR2_Mmus_STKR2 ------------------------------------------------------------ BMPR2_Mmus_STKR2 ------------------------------------------------------------ BMPR1B_Mmus_STKR1 ------------------------------------------------------------ BMPR1A_Mmus_STKR1 ------------------------------------------------------------ ALK7_Mmus_STKR1 ------------------------------------------------------------ ALK4_Mmus_STKR1 ------------------------------------------------------------ ALK2_Mmus_STKR1 ------------------------------------------------------------ ALK1_Mmus_STKR1 ------------------------------------------------------------ ACTR2B_Mmus_STKR2 ------------------------------------------------------------ ACTR2_Mmus_STKR2 ------------------------------------------------------------ daf-4_Cele_STKR2 ------------------------------------------------------------ daf-1_Cele_STKR1 ---GVTV------------QDRKILGPQKPKDESPA------------------------ BMPR1A_Hsap_STKR1 ------------------------------------------------------------ BMPR1B_Hsap_STKR1 ------------------------------------------------------------ BMPR2_Hsap_STKR2 ------------------------------------------------------------ ALK7_Hsap_STKR1 ------------------------------------------------------------ ALK4_Hsap_STKR1 ------------------------------------------------------------ tkv_Dmel_STKR1 ------------------------------------------------------------ put_Dmel_STKR2 ------------------------------------------------------------ SAX_Dmel_STKR1 ------------------------------------------------------------ wit_Dmel_STKR2 ------------------------------------------------------------ BABO_Dmel_STKR1 ------------------------------------------------------------ TGFBR1_Mmus_STKR1 ------------------------------------------------------------ TGFBR2_Mmus_STKR2 ------------------------------------------------------------ sma-6_Cele_STKR1 ------------------------------------------------------------ ALK2_Hsap_STKR1 ------------------------------------------------------------ ALK1_Hsap_STKR1 ------------------------------------------------------------ ACTR2B_Hsap_STKR2 ------------------------------------------------------------ ACTR2_Hsap_STKR2 ------------------------------------------------------------ TGFbR1_Spur_STKR1 ------------------------------------------------------------ ALK2_Spur_STKR1 ------------------------------------------------------------ BMPR1_Spur_STKR1 ------------------------------------------------------------ TGFbRII_Spur_STKR2 ------------------------------------------------------------ ACTR2_Spur_STKR2 ------------------------------------------------------------ BMPR2_Spur_STKR2 ------------------------------------------------------------ AqueK680_Aque_STKR1 ------------------------------------------------------------ AqueK681_Aque_STKR1 IFRGVNLNDTKAAAECGSYENL-KYHPYNFE-DFGSTLVLLWNLMIVNNWHVIVDAYVRR AqueK682_Aque_STKR1 ------------------------------------------------------------ AqueK683_Aque_STKR2 ------------------------------------------------------------ AqueK684_Aque_STKR2 ------------------------------------------------------------ AqueK685_Aque_STKR2 ------------------------------------------------------------ AqueK686_Aque_STKR2 --------------------------P--------K------------------------ TGFbR2_Hsap_STKR2 ------------------------------------------------------------ TGFbR1_Hsap_STKR1 ------------------------------------------------------------ MISR2_Hsap_STKR2 ------------------------------------------------------------ MISR2_Mmus_STKR2 ------------------------------------------------------------ BMPR2_Mmus_STKR2 ------------------------------------------------------------ BMPR1B_Mmus_STKR1 ------------------------------------------------------------ BMPR1A_Mmus_STKR1 ------------------------------------------------------------ ALK7_Mmus_STKR1 ------------------------------------------------------------ ALK4_Mmus_STKR1 ------------------------------------------------------------ ALK2_Mmus_STKR1 ------------------------------------------------------------ ALK1_Mmus_STKR1 ------------------------------------------------------------ ACTR2B_Mmus_STKR2 ------------------------------------------------------------ ACTR2_Mmus_STKR2 ------------------------------------------------------------ daf-4_Cele_STKR2 ------------------------------------------------------------ daf-1_Cele_STKR1 --------------------NG------------APRIVQKEIDRED---EQENWR---- BMPR1A_Hsap_STKR1 ------------------------------------------------------------ BMPR1B_Hsap_STKR1 ------------------------------------------------------------ BMPR2_Hsap_STKR2 ------------------------------------------------------------ ALK7_Hsap_STKR1 ------------------------------------------------------------ ALK4_Hsap_STKR1 ------------------------------------------------------------ tkv_Dmel_STKR1 ------------------------------------------------------------ put_Dmel_STKR2 ------------------------------------------------------------ SAX_Dmel_STKR1 ------------------------------------------------------------ wit_Dmel_STKR2 ------------------------------------------LSL--------------- BABO_Dmel_STKR1 ------------------------------------------------------------ TGFBR1_Mmus_STKR1 ------------------------------------------------------------ TGFBR2_Mmus_STKR2 ------------------------------------------------------------ sma-6_Cele_STKR1 ------------------------------------------------------------ ALK2_Hsap_STKR1 ------------------------------------------------------------ ALK1_Hsap_STKR1 ------------------------------------------------------------ ACTR2B_Hsap_STKR2 ------------------------------------------------------------ ACTR2_Hsap_STKR2 ------------------------------------------------------------ TGFbR1_Spur_STKR1 --------------------------------------MQNTCD-ASQ--SGDDLKGRL- ALK2_Spur_STKR1 ------------------------------------------------------------ BMPR1_Spur_STKR1 ------------------------------------------------------------ TGFbRII_Spur_STKR2 ------------------------------------------------------------ ACTR2_Spur_STKR2 ------------------------------------------------------------ BMPR2_Spur_STKR2 ------------------------------------------------------------ AqueK680_Aque_STKR1 ------------------------------------------------------------ AqueK681_Aque_STKR1 TSIYSRIYFVIWWVLSETVINGILLGYLIEILSITTIRLKDVFKDFNNKSKREKLA--LV AqueK682_Aque_STKR1 ------------------------------------------------------------ AqueK683_Aque_STKR2 ------------------------------------------------------------ AqueK684_Aque_STKR2 ------------------------------------------------------------ AqueK685_Aque_STKR2 ------------------------------------------------------------ AqueK686_Aque_STKR2 ------------------------------------------------------------ TGFbR2_Hsap_STKR2 ------------------------------E-KIPEDGSLNTTK TGFbR1_Hsap_STKR1 ----------------------------------------GIKM MISR2_Hsap_STKR2 -----------------------------------QPACTLSPV MISR2_Mmus_STKR2 --------------------------------PVGDTVQVYVNE BMPR2_Mmus_STKR2 --------------------------------TTVSKDIGMNCL BMPR1B_Mmus_STKR1 ----------------------------------------DIKL BMPR1A_Mmus_STKR1 ----------------------------------------DVKI ALK7_Mmus_STKR1 ----------------------------------------DCKA ALK4_Mmus_STKR1 ----------------------------------------DVKI ALK2_Mmus_STKR1 --------------------------------------KLKTDC ALK1_Mmus_STKR1 --------------------------------------KPKVIH ACTR2B_Mmus_STKR2 ------------------------------T-NV-DLLPKESSI ACTR2_Mmus_STKR2 ------------------------------T-NV-DFPPKESSL daf-4_Cele_STKR2 ------------------------------T-PTPSGTFGTFTT daf-1_Cele_STKR1 --------------------ETAKTP-NGHI-SSNDDSSRPLLG BMPR1A_Hsap_STKR1 ----------------------------------------DVKI BMPR1B_Hsap_STKR1 ----------------------------------------DIKL BMPR2_Hsap_STKR2 --------------------------------TMVSKDIGMNCL ALK7_Hsap_STKR1 ----------------------------------------DCKA ALK4_Hsap_STKR1 ----------------------------------------DVKI tkv_Dmel_STKR1 --------------------------------------VPIKIV put_Dmel_STKR2 ------------------------------T-NIDDAKESTNCL SAX_Dmel_STKR1 ------------------------------------LDFDEVCV wit_Dmel_STKR2 ------------------------------YDDRMMDSSLLNIL BABO_Dmel_STKR1 ----------------------------------------KVKN TGFBR1_Mmus_STKR1 ----------------------------------------GIKM TGFBR2_Mmus_STKR2 ------------------------------E-KIPEDGSLNTTK sma-6_Cele_STKR1 ---------------------------------SGLVESATNQS ALK2_Hsap_STKR1 --------------------------------------KLKTDC ALK1_Hsap_STKR1 --------------------------------------KPKVIQ ACTR2B_Hsap_STKR2 ------------------------------T-NV-DLPPKESSI ACTR2_Hsap_STKR2 ------------------------------T-NV-DFPPKESSL TGFbR1_Spur_STKR1 ------P-------------PSAIIP-T-SH-PPNVPNPYPILS ALK2_Spur_STKR1 ----------------------------------DPYHWEKIIA BMPR1_Spur_STKR1 ----------------------------------------EFKV TGFbRII_Spur_STKR2 ------------------------------Y-TSKGKRGRTTLV ACTR2_Spur_STKR2 -----------------------------RN-SP-SPPPKESNL BMPR2_Spur_STKR2 --------------------------------AKLQANFELECV AqueK680_Aque_STKR1 --------------------------------------RLDFDE AqueK681_Aque_STKR1 CLFIFVPQDLREMFRGEADYEDLDAFHSWNI-FDATFKEKQGES AqueK682_Aque_STKR1 -------------------------------------KEKIQNE AqueK683_Aque_STKR2 ------------------------------M-SPGHVIIAETHL AqueK684_Aque_STKR2 --------------------------------PDNEENPTETTL AqueK685_Aque_STKR2 ---------------------------------VDVTTGQPKSH AqueK686_Aque_STKR2 ----------------------------RLS-DAEHDDTTTSLS