CLUSTAL W (1.83) multiple sequence alignment ROS_Hsap MKNIYCLIPK-------------------------------------------------- sev_Dmel MTTTHINQQAPGTSSSSSNSQNASPSKIVVRQQSSSFDLRQQLARLGRQLASGQDGHGGI ROS_Mmus MKNICWLTLK-------------------------------------------------- ROS_Spur MASIISDT---------------------------------------------------- rol-3_Cele MLSLHLRSLA-------------------------------------------------- AqueK407_Aque ------------------------------------------------------------ ROS_Hsap -------LVNFATLGC-LWISVVQCTVLNS----CLKSCV-TNLGQQLDLGTP------- sev_Dmel STILIINLLLLILLSI-CCDVCRSHNYTVHQSPEPVSKDQMRLLRPKLDSDVVEKVAIWH ROS_Mmus -------LVKFVVLGCIIWISVAQSTVLSS----CLTSCV-TNLGRQLDSGTR------- ROS_Spur ----------------------------GQ----CDAPC-------------R------- rol-3_Cele -----ILFLLFFLL----HDVVKSATVFSSSLKTCQSQCEERNLAYPLDSGEVHWTGLAE AqueK407_Aque ----------------------------------CCCCCF-V--G--------------- ROS_Hsap HN--------------------------------------------------LSEPCIQG sev_Dmel KHAAAAPPSIVEGIAISSRPQSTMAHHPDDRDRDRDPSEEQHGVDERMVLERVTRDCVQR ROS_Mmus YN--------------------------------------------------LSEACIHG ROS_Spur -----------------------------------------------------NSSCSTG rol-3_Cele YNY-------------S----------------------------------SRISSCRHG AqueK407_Aque ------------------------------------------------------------ ROS_Hsap CHF---W--N----------S---VDQKNCALKCNDTYATVC-ERESCEVGCSSAEGAY- sev_Dmel CIVEEDLFLDEFGIQCEKADNGEKCYKTRCTKGCAQWYRALK-ELESCQEACLSLQF--- ROS_Mmus CQF---W--N----------S---VDQETCALKCNDTYATIC-ERESCEVGCSNAEGSY- ROS_Spur CSS---W--D----------N---STLSQCHAVCNETYTSEPFRVQYCQSGCLFAENEY- rol-3_Cele CED---V--D----------E----RESKCDVKCSEEGI----VSNACKQGCRAVLVSFL AqueK407_Aque ------------------------------------------------------------ ROS_Hsap ------------EEEVLENA------------------------DLPTAPFASSIGSHNM sev_Dmel ---------YPYDMPCIGACEMAQRDYWHLQRLAISHLVERTQPQLERAPRADG-QSTPL ROS_Mmus ------------EEEVLEST------------------------ELPTAPFASSIGSHGV ROS_Spur ------------AKAVIDEI------------------------GQPSSPQPSNMGTTSL rol-3_Cele AQAQALLIQVHVNMEVLETSMK---LKWEFPETLAEELKEIANADI-------------- AqueK407_Aque ------------------------------------------------------------ ROS_Hsap TLRWKS---A-NFSGVKYIIQWKYAQLLG-SWTYT-----------------------KT sev_Dmel TIRWAMHFPEHYLASRPFNIQYQFVDHHGE-ELDLEQEDQDASGETGSSAWFNLADYDCD ROS_Mmus TLRWNP---A-NISGVKYIIQWKYAQLPG-SWTFT-----------------------ET ROS_Spur TLSWTA---A-SHQDVRYLVQWRYVEGGGEAWNYYGS--------------------GEP rol-3_Cele --FWF----SQ-TKPLNGILGWRWTSLPQN-SFR-------------------------N AqueK407_Aque ------------------------------------------------------------ ROS_Hsap VSRPSYVVKPLHPFT---EYIFRVVWIFTAQ--LQLYSPPSPSYRTHPHGVPETAPLIRN sev_Dmel EYYVCEILEALIPYT---QYRFRFELPFGENRDEVLYSPATPAYQTPPEGAPISAPVIEH ROS_Mmus VSKLSYTVEPLHPFT---EYIFRVVWIFTAQ--LHLYSPPSPSYRTHPYGVPETAPLILN ROS_Spur ISETTLDITDLIPYA---LYQFRVVWVITPR--HTLTSPATSNVQTQPSGVPSTAPIITS rol-3_Cele SSLSS---EVHVPFEHGEHVEVRLAL--SYRN-QVLVS-RTTTYHLPLSKSGTTLEVIGQ AqueK407_Aque ------------------------------------------------------------ ROS_Hsap IESSSPDTVEVSWDPPQFPGGPILGYNLRLISKN------QK-LDAGTQ----RTSFQFY sev_Dmel LMGLDDSHLAVHWHPGRFTNGPIEGYRLRLSSSE------GNA-TSEQLVPAGRGSYIFS ROS_Mmus MESWSPDTVEVSWAPPHFPGGPILGYNLRLISKN------QK-LDSGTQ----RTSFQFY ROS_Spur IVSSSPTTISLTWDPPPFPNGPIIGYTIAVQNFFNETGIVLD-VDGSTT----EATVVDS rol-3_Cele L-QLSDDRVAVCYR----TNQPTPKFKLTIMTLN------DNTINTEES----IARCHLF AqueK407_Aque ------------------------------------------------------------ ROS_Hsap STLP-NTIYRFSIAAVNEVGEGPEAESSITTSS----SAVQQ-----EEQWLFLSRKTS- sev_Dmel QLQ-AGTNYTLALSMINKQGEGPVAKGFVQTHS-A---RNEKPAKDLTESVLLVGRRAVM ROS_Mmus STLP-NTTYRFSIAAVNEVGEGPEAESTVTTPS----PSVQE-----EEQWLFLSRKTS- ROS_Spur SLRA-LTLYAVSVRARNMEGGGISDMVNVTTGAEPENVAVDY-----WENFIFISDSDG- rol-3_Cele SNLPRDNCCKASISAIDEHGATTA-FVEIKLDF-Y-VNQVEIELVSVASSRLIFSNGTH- AqueK407_Aque -------------------------------------------------------RK--- ROS_Hsap -----------LRKRSLK--HLVDEAHCLRLD-AIYHNITGISVDVHQQI-VYFSEGTLI sev_Dmel WQSLEPAGENSMIYQSQE--ELADIAWS----KREQ-QLWLLNVHGELRS-LKFESGQMV ROS_Mmus -----------LRKRSLK--YLVDEAHCLWSD-AIHHNITGISVYAQQQV-VYFSEGTVI ROS_Spur ----------RIHRRTID------------------------------------------ rol-3_Cele -----------LLESEIDQYALGDSATVIPFPLPTDDTITAIAGISDTTIAIGSSKGSLW AqueK407_Aque ------------------------ETHAFRPD---------------------------- ROS_Hsap WAKKAANMSD------VSDLRIFYRGSGLISSISIDWLYQRMYFIM-DELVCVCDLENC- sev_Dmel SPA----------QQLKLDLGNISSGRWVPRRLSFDWLHHRLYFAM-ESP-----ERN-- ROS_Mmus WMKGAANMSD------VSDLRIFYQGSGLVSSISIDWLYQRMYFIM-DKLVYVCELKNC- ROS_Spur ----PANLTL------ATSEVLYTNQSTAPTKLDVDWLNEQLYFVQ-GTEILRCDLNVS- rol-3_Cele TYQMSANQTDEDQPSSVIQLKTVGEMDTKINQIEIDHIQRTLYAVQHDKGIIRCKLRTME AqueK407_Aque ------------------------------------------------------------ ROS_Hsap -----SNIEEITPPSI-----------SAP-QKIVADSYNGYVFYLLRD-GIYRADLPVP sev_Dmel ----QSSFQIISTDLLGESTQKVGESFDLPVEQLEVDALNGWIFWRNEE-SLWRQDLHGR ROS_Mmus -----SNLEEITPFSL-----------IAP-QKVVVDSYNGYLFYLLRD-GIYRVNLPLP ROS_Spur ------GCSVAVANLG-----------SVP-VEMKVDPFSGYLFWSERDVGIRRTSLTSS rol-3_Cele AEESPNCVLIVNNDAL-----------NAP-KEITLDSVNGHVYTLNADNKVYRTEMVAF AqueK407_Aque ------------------------------------------------------------ ROS_Hsap SGRCAEAVRIVESC---------------------------------------------- sev_Dmel MIHRL--LRIRQ------------------------------------------------ ROS_Mmus SGRDTKAVRIVESG---------------------------------------------- ROS_Spur TVEASSADIIINLLGQSSFTVLSETFQILYSNSTGNSMYSASLDGGNQKAMHVAEDTSNH rol-3_Cele NATGI--ETVAS------------------------------------------------ AqueK407_Aque ------------------------------------------------------------ ROS_Hsap ------------------------------------------------------------ sev_Dmel ------------------------------------------------------------ ROS_Mmus ------------------------------------------------------------ ROS_Spur QFINVTSIVYFNSSLTWTFARETGGVVACAFDPSYNHRDNEQIFFEGNPGQFSQGDLFLC rol-3_Cele ------------------------------------------------------------ AqueK407_Aque ------------------------------------------------------------ ROS_Hsap ------------------------------------------------------------ sev_Dmel ------------------------------------------------------------ ROS_Mmus ------------------------------------------------------------ ROS_Spur VDGYHGLDVFYPTYQPIPIPAFPPTDLQVLFTEDEIGQPSSPQPSNIGTTSLTLSWTAAS rol-3_Cele ------------------------------------------------------------ AqueK407_Aque ------------------------------------------------------------ ROS_Hsap ------------------------------------------------------------ sev_Dmel ------------------------------------------------------------ ROS_Mmus ------------------------------------------------------------ ROS_Spur HQDVRYLVQWRYVEGGGEAWNYFGSGEPISETTLDITDLIPYTLYQFRVVWVITPRHTLT rol-3_Cele ------------------------------------------------------------ AqueK407_Aque ------------------------------------------------------------ ROS_Hsap ------------------------------------------------------------ sev_Dmel ------------------------------------------------------------ ROS_Mmus ------------------------------------------------------------ ROS_Spur SQATSSVQTLPFGVPSTAPTITSIVSSSPTTISLTWDPPPFPNGPIIGYTIAVQNFFNEA rol-3_Cele ------------------------------------------------------------ AqueK407_Aque ------------------------------------------------------------ ROS_Hsap ------------------------------------------------------------ sev_Dmel ------------------------------------------------------------ ROS_Mmus ------------------------------------------------------------ ROS_Spur RIVLGVGGSTTEATVVDSSLRASTLYAVSVRARNMEGEGISDTVNITTGAEPQNLGVVPY rol-3_Cele ------------------------------------------------------------ AqueK407_Aque ------------------------------------------------------------ ROS_Hsap ------------------------------------------------------------ sev_Dmel ------------------------------------------------------------ ROS_Mmus ------------------------------------------------------------ ROS_Spur LVIGVTSLSFTNLSEMSSVSLVEYGKRIIDSDPLLNDIHTVDNENSTISDVAVDYWENFI rol-3_Cele ------------------------------------------------------------ AqueK407_Aque ------------------------------------------------------------ ROS_Hsap ------------------------------------------------------------ sev_Dmel ------------------------------------------------------------ ROS_Mmus ------------------------------------------------------------ ROS_Spur FISDSDGRIHRRTIDPANLTLAPSEVLYTDQSTAPTKLDVDWLNEQLYFVQGTEKLSPQL rol-3_Cele ------------------------------------------------------------ AqueK407_Aque ------------------------------------------------------------ ROS_Hsap ------------------------------------------------------------ sev_Dmel ------------------------------------------------------------ ROS_Mmus ------------------------------------------------------------ ROS_Spur ALAAVCGTFSMKNEESIHYSGEILRCDLNVSGCSVAVANLGSVPVEMKVDPFSGYLFWSE rol-3_Cele ------------------------------------------------------------ AqueK407_Aque ------------------------------------------------------------ ROS_Hsap ---------------------------TLKDFAIKPQAKRIIYFNDTAQVFMSTFLDGSA sev_Dmel ----------------------------PGWFLVQPQHFIIHLMLPQEGKFLEISYDGGF ROS_Mmus ---------------------------TLKDFAVKPQSKRIIYFNDTMQLFMSTFLDGSA ROS_Spur QDVGIRRTSLTSSTVEASSVDIIINLSGQSSFTVLSETFQILYSNSTGNSMHSASLDGSN rol-3_Cele ----------------------------LQYLQ-DMSPSNGIFFDVSKFLLYSALQNGSM AqueK407_Aque ------------------------------------------------------------ ROS_Hsap SHL--------ILPRIPFA----------DVKSFACENNDFLVTDG-KVIFQQDALSFNE sev_Dmel KHP---------LPLPPPSNGAGNGPASSHWQSFALLGRSLLLPDSGQLILVEQQGQAAS ROS_Mmus FHR--------VLPWVPLV----------TVKSFACENNDFLITDG-KAIFQQDSLSFNE ROS_Spur QKA--------M-HVAEDT----------SNHQFINVTSIVYFNSSLTWTFARETGSVAS rol-3_Cele MTLNPVTDHVHIFKDVGYA----------DIQHFRIKN-DLIYWMK-KKCGETDADE--N AqueK407_Aque ------------------------------------------------------------ ROS_Hsap FIVGCDLSHIEE----------------------FGFGNLVIFGSSSQ---------LHP sev_Dmel PSASWPLKNLPD-----------------------CWAVILLVPESQP---------LTS ROS_Mmus FIVGCDLSHIEE----------------------FGFGNLVIFGSSVQ---------SYP ROS_Spur CFLGDPNYNYRDTERIFFEGNPGQFTQGDLFLCVDGYHGLDVFYPTYQ---------PIP rol-3_Cele CIFAENLQRSEE-----------------------DIPNKFTYSSSLMSFGVLEEILLKP AqueK407_Aque ------------------------------------------------------------ ROS_Hsap LPG-RPQELSVLFGSHQALVQWKPPALAIGANVILISDIIELFELGPSAWQNWTYEVKVS sev_Dmel AGG-KPHSLKALLGAQAAKISWKEPERNP--------------YQSADAARSWSYELEVL ROS_Mmus LPG-HPQEVSVLFGSREALIQWTPPALAIG--------------ASPSAWQNWTYEVKVY ROS_Spur IPAFPPTDLQVLFTE------------------------------GEEAWEEWLYEILLT rol-3_Cele RIT-AVSTIAMLTSDKTARVSWDESNTLP-------------FQAQGSSWRNFTYFLKVT AqueK407_Aque ------------------------------------------------------YE---- * ROS_Hsap TQDPPEVTHIFLNISGTMLNVPELQSAMKYKVSVRASSPKR-PGPWSEPSVGTTLVPA-S sev_Dmel DVASQS-AFSIRNIRGPIFGLQRLQPDNLYQLRVRAINVDGEPGEWTEPLAARTWP-L-G ROS_Mmus SQDILEITQVFSNISGTMLNVPELQSSTKYTVSVRASSPKG-PGPWSAPSVGTTLVPA-T ROS_Spur NLQIGN-TVTLTGLQEDSALVDNLNGSTEYSVQVRAYSIGG-LGPLSETFSGSTLIEV-D rol-3_Cele APDITDFSPIEIYTSNTEMKI-DVTPGNIYNAQVQVCSDDFCSIPTS--TSNTALPDLGD AqueK407_Aque ------------------------------------------------------------ ROS_Hsap EPPFIMAVKE-DGLWSKPLNSFGPG-EFLSSDIGNV-SDMDWYNNSLYYSDTKGDVFV-- sev_Dmel PHRLRWASRQ-GSVIHT--NELGEGLEVQQEQLERLPGPMTMVNESVGYYV-TGDGLLHC ROS_Mmus EPPFIMAVKE-DGLWSKPLCSFGPG-EFLSSDVGNV-SDMDWYNNSLYYSDTKGNVYV-- ROS_Spur VEPYLILANA-TDVWRSQLDGNAES-RLLSP-QATI-KDIEWYQGYYIWSSTMGDLY--- rol-3_Cele VVPFVFTKRQADDIISV--DILGNIIPAD------------------------------- AqueK407_Aque ------------------------------------------------------------ ROS_Hsap ----WLLNGTDISENYH-L-PSI-AGAGALAFEWLGHFLYWAGKTY-VIQRQ------SV sev_Dmel INLVHSQWGCPISEPLQ--------HVGSVTYDWRGGRVYWTDLARNCVVRM------DP ROS_Mmus ----RPLNGMDISENYH-I-PSI-VGAGALAFEWLGHFLYWAGKTY-VIQRQ------SV ROS_Spur ----RSAEGDVIEEQLTFVPPGVRSSVDAIAVDWLSEFIYWADRDQNQIIRGRLSNQSSV rol-3_Cele -------DSVKIVEKLQ---------YPHV-LDNTTKTVYLAG--DHSVSRS------I- AqueK407_Aque ------------------------------------------------------------ ROS_Hsap LTGHTDIVTHVKLLVNDMVVDSVGGYLYWTTLYSVESTRLNGESS--LVLQTQPWFSGKK sev_Dmel WSGSRELLPV--FEANFLALDPRQGHLYYATSSQLSRHGSTPDEA--VTYYRVNGLEG-S ROS_Mmus LTGHTDIVTHVKLLVNDMAVDSVGGYLYWTTLYSVESTRLNGESS--LVLQAQPWLSGKK ROS_Spur VTSPTSINA-FANDVQDIAIDSVQAYIYWTSSSSVEGSRLNGESP--LVFYEIGDLSLDV rol-3_Cele --------------------------ILIASSYKITSYRLPTTFDFEYFSCEEPLEACSE AqueK407_Aque ------------------------------------------------------------ ROS_Hsap VIALTLDLSDGLLYWLVQDSQ-C----IHLYTAVLRGQSTGDTTITEFAAWSTSEISQNA sev_Dmel IASFVLDTQQDQLFWLVKGSG-A----LRLYRAPLTAGGDSLQMIQQIKGVFQAVPDSLQ ROS_Mmus VIALTLDLSDGLLYWLVQDNQ-C----IHLYTAVLRGWSGGDATITEFAAWSTSEISQNA ROS_Spur VAGLTLDLGGGYVYWFVVSRQ-GVTEELKLFRARLAGISPDPMSTTEEIGEVLSETTSLA rol-3_Cele VMGISSDDTTGMVHFLTQARNGT----ITLWESDPENR-----TPRDIASVPSIVPFRRF AqueK407_Aque ------------------------------------------------------------ ROS_Hsap LMYYSGRLFWING--FRIITTQEIGQKTSVSVLEPARFNQFTIIQT-SLKPLPGNFSFTP sev_Dmel LLRPLGALLWLERSGRRARLVRLAAPLDVMELPTPDQASPASALQLLDPQPLPPRD---E ROS_Mmus LMYYSGRLFWING--FRIITAQEIGQRTSVSVSEPAKFNQFTIIQT-SLKPLPGNFSSTP ROS_Spur LHFYSSKLFWINSQ-SRVEVSDDRGQRQALL--PATDVQALTIVQE-TLKPLPEGYSERP rol-3_Cele LILHDKMILVT-KNN------HIVQTDKKLK-----VVNVATELERV-DHILPLRY---A AqueK407_Aque ------------------------------------------------------------ ROS_Hsap KVIPDSV-QESSFRI-EGNASSFQILWNGPPAVDWGVVFYSVEFSAHS------KFLASE sev_Dmel GVIPMTV-LPDSVRLDDGHWDDFHVRWQPSTSGGNHSVSYRLLLEFGQ------RLQT-L ROS_Mmus KVIPDPV-QESSFRI-EGHTSSFQILWNEPPAVDWGIVFYSVEFSTHS------KFLIIE ROS_Spur TVVAEEI-SPSSIQV-TGTWDDFNITWQASTEVNYGIVFYTIAVTAPE------QTYT-E rol-3_Cele T-ISHKIEFSDEIKFIDGSKTNLQ--WTLSPPLEAGTVLFKVSIFREKMGGQDPPIIT-I AqueK407_Aque ------------------------------------------------------------ ROS_Hsap QH----SLPVFTVEGLEPYA-LFNLSVTPYTYWGKGPKTSLSLRAPETVPSAPENPRIFI sev_Dmel DL----STPFARLTQLPQAQLQLKISITPRTAWRSGDTTRVQLTTPPVAPSQPRRLRVFV ROS_Mmus QQ----SLPIFTVEGLEPYT-LFNLSVTPYTYWGKGQKTSLSFRAPESVPSAPENPRIFI ROS_Spur TV----QSASYNIKNLTPFQ-SLDITISPYTYWATTPETAAQMMSPMSVPSVPLNPRAFA rol-3_Cele QSETNFTIPSEVLEAWSSAQ-RFDVSVQAMTPWATAVLNRTGLTAPVKPPTSPTQLRIFA AqueK407_Aque ------------LRGLRALN-SRT------------------------------------ : ROS_Hsap LPSGKC-CNKNEVVVEFRWNKPKHENGVLTKFEIFYNISNQSITNKTCEDWIAVNVTPSV sev_Dmel ERLATA-LQEANVSAVLRWDAPEQGQEAPMQA-LEYHISCWVGSELHEE----LRLNQSA ROS_Mmus LSSGRY-TKKNEVVVEFRWNKPKHENGVLTKFEIFYHISKQSGTNRSTEDWMSASVIPPV ROS_Spur IDSTDIMTGTTMYSAEFRWSEPAEINGVFEGYNVSW------GTDV--EQLTVFNVSVDV rol-3_Cele TQQ-KT-VDGPRALISFFWGPPSEWNGTPYQ--YIVNCTKDDGKL--------ITIDSSE AqueK407_Aque ------------------------------------------------------------ ROS_Hsap MSFQL-----EG------------MSPR-----------------CFIAFQVRAFTS--- sev_Dmel LEARV-----EH------------LQPD-----------------QTYHFQVEARVAATG ROS_Mmus MSFQL-----EA------------VSPE-----------------YTVAFQVRVFTS--- ROS_Spur DVFSF-----AN------------LTAN-----------------TTYFFQVEGFTS--- rol-3_Cele LKPLVKLFAIDSTNSLISINDLAHEEPRRETRQVAQPVKLEYQAMAFIGEDLYAVR---K AqueK407_Aque ------------------------------------------------------------ ROS_Hsap KGPGPYADVVKSTTSEINPFPHLITLLGNKIV-FLDMDQNQVVWTF-S--AERVISAVCY sev_Dmel AAAGAASHAL-HVAPEVQAVPRVLYANAEFIG-ELDLDTRNRRRLVHT--ASPVEHLVGI ROS_Mmus KGPGPFSDIVMSKTSEIKPCPYLISLLGNKIV-FLDMDQNQVLWTF-S--LEGDVSTVGY ROS_Spur VGSGPATDPVSITTGVSPPPPTIVVSKGNAGVTLTDPDTKEEIPLL-G---GIAISVVAF rol-3_Cele EGESAQPVLV-------------------------QIDTNHIDNTVHKVSIGGDVTRIDA AqueK407_Aque ------------------------------------------------------------ ROS_Hsap TADNEMG---YYAEGDSLFLLHLHNRSSS------ELFQDSLVFDITVITIDWISRHLYF sev_Dmel EGEQRLL---WVNEH-VELLTHVPGSAPA------KLAR--MRAEVLALAVDWIQRIVYW ROS_Mmus TTDDEMG---YFAQGDTLFLLNLRNHSSS------KLFQDALVSDIRVIAVDWIARHLYF ROS_Spur VASEDKV---FFVE---------------------------------------------- rol-3_Cele MTSDWVGNRLIFVAGTNVYQLSLEPFLSTSLLNPHKLIQLTSATDAKQLAYDPFMNTAYL AqueK407_Aque ----------------------------Q------SLTNPH------------------- ROS_Hsap ALKESQ--NGMQVFDVDL---EHKVKYPREVKIHNRNSTIISFSVYPLLSRLYWTEVSNF sev_Dmel AELDATAPQAAIIYRLDLCNFEGKILQGERVWSTPRGRLLKDLVALPQAQSLIWLEYEQG ROS_Mmus ALKASQ--NGTQIFNVDL---EHKVKSPREVKTCKAHTTIISFSIYPLLSRLYWTEVSDL ROS_Spur ------------------------------------------------------------ rol-3_Cele L---TK--NGS-LFALDM---NKNTEANLAL----TVSCLASQTVTWMMTEFAWNRASS- AqueK407_Aque ----------------------------------------------------YWS----- ROS_Hsap GYQMFYYSIISHTLHRILQPTATNQQNKRNQCSCNVTEFELSGAMAIDTSNLE----KPL sev_Dmel S------------------PRN----------------GSLRGRNLTDGSELEWATVQPL ROS_Mmus GHQMFYCNISNHTSQHVLQPKASNQ-HGRSQCSCNVTESELSGAMTVDTSDPD----RPW ROS_Spur ------------------------------------------------------------ rol-3_Cele ----------------------------------------------------------PK AqueK407_Aque ------------------------------------------------------------ ROS_Hsap IYFA------KAQEIWAMDL-EGCQCWRVITVPAMLAG---KTLVSLTVDGDLIYWIITA sev_Dmel IRLHAGSLEPGSETLNLVDN-QGKLCVYDVARQLCTAS---ALRAQLNLLGEDSIAGQLA ROS_Mmus IYFT------KRQEIWAMDL-EGCQCWKVIMVPT-IPG---KRIISLTVDGEFIYWIMKT ROS_Spur -----------------------------------------------------------T rol-3_Cele IYAL------TWNGLIYVDLTEDSQCNEVRIDWTKFGDKGLKDISSFAIADKLFAFV-T- AqueK407_Aque ------------------------------------------------------------ ROS_Hsap KDSTQIYQAKKGN--------GAIVSQVKALRSRHILAYSSV-MQPFPDKAFLSLASDT- sev_Dmel QDSGYLYAVKNWSIRAYGRRRQQLEYTVELEPEEVRLLQAHN-YQAYPPKNCLLLPSSGG ROS_Mmus KDDAQIYQAKKGS--------GAILSQVKASRSKHILAYSSA-LQPFPDKAYLSLASDM- ROS_Spur SGDLEIYRSKL-D--------GSDREEVE--------GFTSVGSGPATDPVSITTGVSP- rol-3_Cele SSEMLIY----------GKDTV-TPITIANPPLKQILAVSQS-SQPYPERSCFELPSSKG AqueK407_Aque ------------------------------------------------------------ ROS_Hsap VEPTILN-ATNTSLTIRLPLAKTNLTWY-GITSPTPTYLVYYAEVNDRKNSSDLKYR--- sev_Dmel SLLKATD-CEEQRCLLHLPMITASEDC--PLPIPGVRYQLNLTLAK-EPGSEEHDHGMEP ROS_Mmus VEATILY-ATNTSLTLKLPPVKTNLTWH-GITHPTSTYLIYYMEAN-RANSSDRRHK--- ROS_Spur PPPTIVVSKGNAGVTLTDPDTKEETPLLGGIAISVVAFVA-------------------- rol-3_Cele IVFSIVN-EGKTGSFLEVTKSSSSSSCQ-EVSMPQTQYEIYFTRK----NTDKVKH---- AqueK407_Aque ------------------------------------------------------------ ROS_Hsap ----ILEFQDSIALIED-LQPFSTYMIQIAVKNYYSDPLE---HLPPGKEIWGKTKNGVP sev_Dmel LGQWLLGAGESLNLT-D-LLPFTRYRVSGILSSFYQKKLALPTLVLAPLE--LLTASATP ROS_Mmus ----MLESQENVARIEG-LQPFSMYMIQIAVKNYYSEPLE---HLPLGKEIQGQTKSGVP ROS_Spur ------------------------------------------------------------ rol-3_Cele ----VRSFSDRIHVENGILDKETDYDVTVTWLNRYS-PAS---GVSASKS--FRTGFGYP AqueK407_Aque ------------------------------------------------------------ ROS_Hsap EAVQLINTTVRSDTSLIISWRESHKPNGPKESVRYQLAISHLAL-IPE--TPLRQSEFPN sev_Dmel SPPRNFSVRVLSPRELEVSWLPPEQLRS--ESVYYTLHWQQELDGENV--QDRREWEAHE ROS_Mmus GAVCHINATVLSDTSLHVFWTESHKPNGPKESVRYQLVMSYLAP-IPE--TPLRQGEFPS ROS_Spur -------------SEDKVFFV------------------------------------ETS rol-3_Cele SAPRDPHAIPVTPDTVYLYWNLPETLNAPISEIKYKISQQAAGISVPTSIAVIALSETVS AqueK407_Aque ------------------------------------------------------------ ROS_Hsap GRLTL-----L-------VTRLSGGNIYVLKVLACHSEEMWCTESHPVTVEMF------- sev_Dmel RRLETAGT-HR-------LTGIKPGSGYSLWVQA-HATPTKSNSSERLHVRSFAELPELQ ROS_Mmus AKLSL-----L-------ITKLSGGQLYVMKVLACHPEEMWCTESHPVSVNMF------- ROS_Spur GDLEI-----Y-------RSKLDGSDREE------------------------------- rol-3_Cele SNISSDTTSCLINPCRVKIANLRPSNEYKFWVTA----------THISHLDAATILKDDD AqueK407_Aque ------------------------------------------------------------ ROS_Hsap --------NTPEKPYSLVPEN---TSLQFNWKAPLNVN-LIRFWVELQKWKY-NEFYHVK sev_Dmel LLELGP------------------YSLSLTWAGTP-DP-LGSLQLECRSS---AE--QLR ROS_Mmus --------DTPEKPSALVPEN---TSLQLDWKARSNVN-LTGFWFELQKWKY-NEFYHVK ROS_Spur ------------------------------------------------------------ rol-3_Cele AVSSEAVARTLDVPGTLRPDNVTGSSLLLRWNGLEPEHRPSSIAVQYRESGGANNEWQFP AqueK407_Aque ------------------------------------------------------------ ROS_Hsap TS--CS-QGPAYVCNITNLQPYTSYNVRVVVVYKTGE-----------NSTSLPESFKTK sev_Dmel RNVA----GNHTKMVVEPLQPRTRYQCRLLLGYAATPGA--------PLYHGTAEVYETL ROS_Mmus AS--CS-QGPVYVCNITDLQPYTSYNIRVVVVYTTGE-----------NSSSIPESFKTK ROS_Spur ------------LLELGNQQPYQAGFV--------------------------------- rol-3_Cele MNVSFEPDVTTELVPITNLLSATSYDYRFVATYTGTYTIDGKVLAFKEDYLQLPQQARTK AqueK407_Aque ------------------------------------------------------------ ROS_Hsap AGVPNKPGIPKLLEGSKN--SIQWEK-AEDNGCRITYYILEIRKSTSNN--LQNQN-LR- sev_Dmel GDAPSQPGKPQLEHIAEEVFRVTWTA-ARGNGAPIALYNLEALQARSD---IRRRRRRRR ROS_Mmus AGVPSKPGIPKLLEGSKN--SIQWEK-AEDNGSRLMYYTLEVRKGISND--SQNQS-SR- ROS_Spur ---------------------IDWV----------------------------------- rol-3_Cele AGVPTAPQFVEAKQDEEG-WIVTWKEPMSDGGSPITSYAVETRINKTAEWEIAERGLDG- AqueK407_Aque ------------------------------------------------------------ ROS_Hsap ----------------------WKMTFNGSCSSVCTWKSKNLKGIFQFRVVAAN-NLGFG sev_Dmel RNSGGSLEQLPWAEEPVVVEDQWLD-FCNTTELSCIVKSLHSSRLLLFRVRARSLEHGWG ROS_Mmus ----------------------WKVVFNGSCSSICTWRSKNLKGTFQFRAVAAN-EIGLG ROS_Spur -------------------------------SQILYWSDNS--AIYSF------------ rol-3_Cele ----------------------WKTWWRPGKSDTTSSTSTSSTEVSEFRIRAAN-IEGFG AqueK407_Aque --------------------------------------RDN------------------- ROS_Hsap EYSGISENIILVGDDFWIPET--SFILTIIVGIFLVV-TIPLTFVWHRRLK--NQK---- sev_Dmel PYSEESERVA---EPFVSPEKRGSLVLAIIAPAAIVS-SCVLALVLVRKVQ--KRRLRAK ROS_Mmus EYSEISEDITLVEDGVWITET--SFILTIIVGIFLVA-TVPLTFVWHRSLK--SHK---- ROS_Spur -----------------------------------DT-TLPVSMAIMEEVYEAPEG---- rol-3_Cele AYAYTEDKKEE-KEEEPSSVLPYLLLLSI---IFLLAAMILVACF--------------- AqueK407_Aque ------------------------------------------------------------ ROS_Hsap -SAK-------EGVTVLINEDKELAELRGLAAGVGLANACYAIHTLPTQEEIENLPAFPR sev_Dmel KLLQQSRPSIWSNLSTLQT-QQQLMAVRNR-----------AFSTTLSDADIALLPQINW ROS_Mmus -ASK-------EGLSVLNDNDKELAELRGLAAGVGLANACYAVHTVPTQEEIENLPAFPR ROS_Spur -NTV-------EGISV--NPHGK-MAIRQ-------ENSNY---------------AVTS rol-3_Cele ----------------------------------------------------WYLPVVNY AqueK407_Aque --------------------------------------------FKCTEEDLESLNKFPR . ROS_Hsap EKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMS sev_Dmel SQLKLLRFLGSGAFGEVYEGQLKT--EDSEEPQRVAIKSLRKGASE--FAELLQEAQLMS ROS_Mmus EKLSLRLLLGSGAFGEVYEGTAIDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMS ROS_Spur EKLSLEHMSEHGSYKML-------------NVLILQLMTLRKGATDEDKQEFLKEATVMG rol-3_Cele STVTFNDYIDTCAYGIVHSGTAEEVPMSWEKDVRVAIKKLKPNHSFQEKMMFMKEAILLN AqueK407_Aque NKLRLENFIDRGEFGEVYQGTALDILGQGTGPTPVAVKTLRKGSTEDEQRKFLSEAALMS . : : : : : : .*: . : ::.** ::. ROS_Hsap KFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGP----LLTLVDLVD sev_Dmel NFKHENIVCLVGICFDTESISLIMEHMEAGDLLSYLRAARATSTQEPQPTAGLSLSELLA ROS_Mmus KFNHPNILKQLGVCLLGEPQYIILELMEGGDLLSYLRKARGTTFHGP----SLTLLDLVE ROS_Spur KFKHPNIVLLMGVCLDNDPQYIIQELMEGGDLLCYIRAARMPAPTNS----KITLMDQIE rol-3_Cele NLDHPNIVKELGVCITPGQELILLEYMEGGNLLKFLQKSTPNEYQSS----ELSPRDLLS AqueK407_Aque NFNHINIVKVLGVCLNNDPIYIIMELMPGGDLLKFLREARRD-HGPP----LLTQSELVQ ::.* **: :*:*: :: * * .*:** ::: : . :: : : ROS_Hsap LCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYT--SPRIVKIGDFGLARDIYKNDYYR sev_Dmel MCIDVANGCSYLEDMHFVHRDLACRNCLVTESTGSTDRRRTVKIGDFGLARDIYKSDYYR ROS_Mmus LCVDISKGCVYLEQMHFIHRDLAARNCLVSVKDYT--SPRVVKIGDFGLAREIYKNDYYR ROS_Spur IILDTVKGCEHLEELHFVHRDLAARNCLVSTKSYEA-HERVVKIGDFGLARDIYKNDYYR rol-3_Cele ISVDIARGMNYLERLPHVHKNLSARKCLLAGR------PGVTKL-EMGMSKELSNGQVNR AqueK407_Aque VALDVAQGCRYLEQQHFIHRDIAARNCLVSSKG----ADRVIKIGDFGLAKDLYSSDYYQ : :* .* :** .:*::::.*:**:: *: ::*::::: ..: : ROS_Hsap KRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQT sev_Dmel KEGEGLLPVRWMSPESLVDGLFTTQSDVWAFGVLCWEILTLGQQPYAARNNFEVLAHVKE ROS_Mmus KRGEGLLPVRWMAPENLMDGIFTSQSDVWSFGILVWEILTLGHQPYPAHSNLDVLNYVQA ROS_Spur KEGEGLLPVRWMAPEGLMDGYFSVQSDVWAFGILMWEVMSRGQQPYPARSNVEVLRFVEA rol-3_Cele SDLENMEIVRWMAPEVLKDFQFSSKSDVWAYGVLLYEVFSFGEVPYGDKDNRRIMTDVRN AqueK407_Aque VEGQRKLPVRWMAPEALTQGKFSIESDVWSFGILLWEIMTFGNQPYPGRTNQEVLQFVTG : ****:** * : *: :****::*:* :*::: *. ** : * :: * ROS_Hsap GGRLEPPRNCPD-DLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLNSI-YKSRDEAN sev_Dmel GGRLQQPPMCTE-KLYSLLLLCWRTDPWERPSFRRCYNTLHAISTDLRRTQM--AS---- ROS_Mmus GGRLEPPRNCPD-DLWNLMSQCWAQEPDQRPTFHNIQNQLQLFRNVFLNNV-SHCGEAAP ROS_Spur GGRLSQPDQCPD-EIYMMMRRCWERSTEDRPSFKMLKEMIQDYRRKS-----------VG rol-3_Cele GSVLPIPSYCPSKRIYKVIKQCLTSDSTKRANFATILKIFETFRDDQKCQDD--KP-IQF AqueK407_Aque DGRLDKPEDCSS-RLYKLMQCCWKKYASERPKFAQIVDVISSYWDHLNNKRDSYCSDD-- .. * * *.. :: :: * . .*..* . : ROS_Hsap NSGVINESFEGEDGDVICLNSDDIMP----VALMET----------K-NRE-------GL sev_Dmel ----------ATAD-TVV------------------------------------------ ROS_Mmus TGGVINKGFEGEDDEMVTLNSDDTMP----VALMET----------K-NQE-------GL ROS_Spur PNGADNFAFEGDG-KVDYSRLKDIPP--EMEDYLLPIDSKGDIIKDKPNIELPPDIDYDL rol-3_Cele NDGTDNTNFSASQD-STSSREPP-SPSHRMRDFIDT----------R-DLE-------PP AqueK407_Aque --------------------DDEEL-----EDILQR----------RPSRP-------SR ROS_Hsap NYMVLA-------------------------------TECGQGEEKSEGPLGSQESESCG sev_Dmel --------------------------------------SCSRPEFKVRFDG--------- ROS_Mmus NYMVLA-------------------------------TKCSQGEGSYEGPLGPKELGSCD ROS_Spur AEKDLASASFKEEQKKEKRKGSKK--G-SLRGRLPGGASAADPTPRLEAAL--------- rol-3_Cele SPSHLNQSFGGFEHPYEGERPATMWNGSGARNSAKNSIGRSMKKEKLRNPI--------- AqueK407_Aque TSSVRSGFVNL----------------------ARQGSMRIRNSFRRRGSL--------- . ROS_Hsap LRKEEKEPHA----DK-----DFC------------------------------------ sev_Dmel QPLEEHREHNERPEDE-----NL------------------------------------- ROS_Mmus LKKDKKQPQA----DK-----DFC------------------------------------ ROS_Spur HDLENNRERGRDIDDQ-----RYLKY---------------------PVGSVSKATGAGV rol-3_Cele HSMDDLVARNQRPLSIHSEDTESTDYGASSSMYSPGSSNRISSQVDPPIGRLSSAPGIGI AqueK407_Aque HRKEEHDS---------------------------------------------------- :. ROS_Hsap ------------------------------QEKQV------------------------- sev_Dmel --------------TL---REVPLKDKQL------------------------------- ROS_Mmus ------------------------------QEPQV------------------------- ROS_Spur ANATDGAVGGATGPAVD----------DGSAEGAVGYSAGATMNGDAPNRTDLSNYAQAG rol-3_Cele VNDAFE----SSNPSLNLSRSWAGLSREVNQNPAGAGSS-----GTLPQ----------- AqueK407_Aque ------------------------------------------------------------ ROS_Hsap ---------------------AYCPSGK--------PEGLNYACLTHSGYG-DGSD sev_Dmel ----------------------------------------------YANEG-VSRL ROS_Mmus ---------------------AYGSPGL--------SEGLNYACLAHSEHG-DVSE ROS_Spur KRHPNPFRANSMEELDGYDNLSFASSGAKASGGAKPSGGISVTGD-ITATD-YANV rol-3_Cele -------HTNSAGHLRL-PGVQVGAGGGRVYRNASGGGG-------PSNRGRISQV AqueK407_Aque -------------------------------------HGQNHAGL-NSE---EDLV :