CLUSTAL W (1.83) multiple sequence alignment NIK_Hsap MAVMEMACPGA-------------------PGS----AVGQQKELPKAK----------- NIK_Mmus MAVMEVACPGT-------------------PGS----AVGQQKELAKAK----------- COT_Mmus MEYMSTGSDEKEE--IDLLIK--------------------------------------- COT_Hsap MEYMSTGSDNKEE--IDLLIK--------------------------------------- DDB0229972_Ddis MEQEDQQYEEDS----SQFNK-----NNYVPDD-----NSGEKEQPATT----------- DDB0229973_Ddis MELSEPKQRFESL--LSLFEDVA---NKRYSGDFSVKKNINAPQVPPRSYSLFNVTGGNV DDB0230010_Ddis MKSFLNKNKNSKK--IIILDD--------------------------------------- IfkA_Ddis MANSNNNNNSNNNNNNSTFGY-SNSECSGSSGN----LLMT--LDPDNN----------- CC1G_01579_Ccin MTHLDPPITSS-------------------TRS----A---------------------- AqueK223_Aque MIPVLRV-----------------------TGM----ADQQQQQQPGGG----------- STE-Un_a_Smoe MDGTGSRNSGN------------------------------RSKLGVES----------- STE-Un_b_Smoe MVEPWLAFSAG-------------------GSD----AIPGLSEGIIFP----------- * NIK_Hsap --------------------------------------------------------EKTP NIK_Mmus --------------------------------------------------------EKTQ COT_Mmus ------------------------------------------------------------ COT_Hsap ------------------------------------------------------------ DDB0229972_Ddis --------------------------------------------------------TEIT DDB0229973_Ddis SSYNNQQQQQNNNNNNNNNNNNNNNNNNNNNNNNNNSGEISSNNSTPSILFSPTPTSTAP DDB0230010_Ddis ------------------------------------------------------------ IfkA_Ddis ---QSQL-------------------------------------------------EEIE CC1G_01579_Ccin --------------------------------------------------------QI-- AqueK223_Aque --------------------------------------------------------GRPS STE-Un_a_Smoe --------------------------------------------------------RRCK STE-Un_b_Smoe --------------------------------------------------------EREE NIK_Hsap PLGKKQ-------------------------------SSVYK------------------ NIK_Mmus SLGKKQ-------------------------------SCIFK------------------ COT_Mmus ------------------------------------------------------------ COT_Hsap ------------------------------------------------------------ DDB0229972_Ddis T-TTTT------------------------------------------------------ DDB0229973_Ddis P-APPQPTTPPNTGFHNRPLSININQQPIGGVNNNNNNNNKDS----------PSN-KPL DDB0230010_Ddis ------------------------------------------------------------ IfkA_Ddis C-L----------------------------------KSIYRD----------EFE-ELP CC1G_01579_Ccin ------------------------------------------------------------ AqueK223_Aque S-TKRV-------------------------------DSQQQL----------QRQ-DSG STE-Un_a_Smoe T---------------------------------------------------LGS----- STE-Un_b_Smoe SA--LQ-------------------------------ACLFRNKSRIREFFSEARVSKEP NIK_Hsap ------------------------------------LE--AVE-----KSPVFCGKW-EI NIK_Mmus ------------------------------------LE--AVE-----KSPVFCGKW-EI COT_Mmus ------------------------------------------------------------ COT_Hsap ------------------------------------------------------------ DDB0229972_Ddis ------------------------------------------------------------ DDB0229973_Ddis RLSGSPPTASINGNQIEQLQRELRNEKEAHQQTKYLLN--SF-ADENKKLSNDCQLW-RA DDB0230010_Ddis --------------------NDFSKYQQRY-----DLQNQNI---EIVSSPLQNIRS-QQ IfkA_Ddis -------------------------------------------------TEAVCRRF-KI CC1G_01579_Ccin ------------------------------------------------------------ AqueK223_Aque FLSGA-------------------------------------------PTPVTPSRP-EM STE-Un_a_Smoe ------------------------------------------------------------ STE-Un_b_Smoe VLV---------------------------RVLVGSKE--GIEKWLKVSGPASCCLWVEI NIK_Hsap -----------------------------------------LND-VITKGTA-------- NIK_Mmus -----------------------------------------LND-VITKGTA-------- COT_Mmus ------------------------------------------------------------ COT_Hsap ------------------------------------------------------------ DDB0229972_Ddis ------------------------------------------------------------ DDB0229973_Ddis ----------------------------------------KYFK-LLTKNTK-LKVIFDH DDB0230010_Ddis -----------------------------------------INDGVQMSGSIQSDLSSSD IfkA_Ddis TLIPHPTNQYQNFCAVRLYVKYSPNYPVSLPTIELEKVRGLSDD-LIGELSF-------- CC1G_01579_Ccin ------------------------------------------------------------ AqueK223_Aque -----------------------------------------NAN-QPQQGGG-------- STE-Un_a_Smoe ------------------------------------------------------------ STE-Un_b_Smoe -----------------------------------------SDD-RLTRGIV-------- NIK_Hsap ----KEGSE---------------------------------------------AGPAAI NIK_Mmus ----KDGSE---------------------------------------------GGPPAI COT_Mmus ------------------------------------------------------------ COT_Hsap ------------------------------------------------------------ DDB0229972_Ddis -----------------------------------------------------------T DDB0229973_Ddis FQSIMNESD---------------------------------------------SVPGEG DDB0230010_Ddis NFTSSGGFG---------------------------------------------GG---- IfkA_Ddis ----LLSQK---------------------------------------------MAPGEI CC1G_01579_Ccin -------------------------------------------------------NPPPL AqueK223_Aque ----QSGGH---------------------------------------------LVPRDS STE-Un_a_Smoe ------------------------------------------------------------ STE-Un_b_Smoe ----PSSGEEFFTSQVKLAYRFRAVTASYLTILAGTFVVLSAYRKSRFELRENGGGTEAH NIK_Hsap SII------------------------------AQAECENSQEFS--------------- NIK_Mmus SII------------------------------AQAECENSQEFS--------------- COT_Mmus ------------------------------------------------------------ COT_Hsap ------------------------------------------------------------ DDB0229972_Ddis ------------------------------------------------------------ DDB0229973_Ddis SLV------------------------------HSTSYNSSSSSSSGGGGNI-------- DDB0230010_Ddis ------------------------------------------------------------ IfkA_Ddis IIF------------------------------E--LCQAVQEFLL-----L-------- CC1G_01579_Ccin AI-------------------------------------QTTEWS--------------- AqueK223_Aque ------------------------------------------------------------ STE-Un_a_Smoe ------------------------------------------------------------ STE-Un_b_Smoe SLFVKWLLIMPATAFHQLLCMVEPGGALAEFQIVLRQLVDSTNFAD-----VGFRHLDFS NIK_Hsap ------------------------------------------------------------ NIK_Mmus ------------------------------------------------------------ COT_Mmus ------------------------------------------------------------ COT_Hsap ------------------------------------------------------------ DDB0229972_Ddis ------------------------------------------------------------ DDB0229973_Ddis ---------TPRKLS--------------------------------------------- DDB0230010_Ddis ------------------------------------------------------------ IfkA_Ddis ---------YNKETVSLHEEMIKRLNTNINRVNSSDDINNNNNNNNDDDDDNDDYDDSDD CC1G_01579_Ccin ------------------------------------------------------------ AqueK223_Aque ------------------------------------------------------------ STE-Un_a_Smoe ------------------------------------------------------------ STE-Un_b_Smoe CWLAHFPFVLTFEGVDLL-VMTRDLRWTIMRFDCSEGKLKI------------------- NIK_Hsap ----------------------------------------PTFSERIF-IAGSKQYSQS- NIK_Mmus ----------------------------------------PTFSERIF-IAGSQQYSQS- COT_Mmus ------------------------------------------------------------ COT_Hsap ------------------------------------------------------------ DDB0229972_Ddis ------------------------------------------------------------ DDB0229973_Ddis ----------------------LAG---------------------------GGKFDDAP DDB0230010_Ddis --------------------------GNSSSNTSNRNS--DNSTQRPLMVDIGLEYKYR- IfkA_Ddis ENSDSDYDDYDDSDDENSDDEFYSD---------------------------DEDYNT-- CC1G_01579_Ccin ----------------------------------------DDRFEEVE-IIASRNRR--- AqueK223_Aque ------------------------------------------------------------ STE-Un_a_Smoe ------------------------------------------------------------ STE-Un_b_Smoe ------------------------GKGRFSADTSRESLGVSFYSEKAF-QVHEWELWDS- NIK_Hsap ---------ESLDQ--------------IPNNVAH-------------------ATEGKM NIK_Mmus ---------ESLDQ--------------IPNNVAH-------------------ATEGKM COT_Mmus ------------------------------------------------------------ COT_Hsap ------------------------------------------------------------ DDB0229972_Ddis ----------TPTA--------------IDNNDSD-------------------LTEDVI DDB0229973_Ddis QSA------SALLK--------------IHHQRNQ-------------------STGSAF DDB0230010_Ddis ---------LALEQNPNDFKALVKWGSLIYKNIKN-------------------QMGGKH IfkA_Ddis -RHQMGDIGSSVNK--------------IINSIDHTISHGGGVGVGIGSGNGLFSKSSSS CC1G_01579_Ccin ------------------------------------------------------------ AqueK223_Aque ----------SLPP--------------IPERSSP-------------------AGHQEM STE-Un_a_Smoe ---------------------------AIPEEMVL-------------------LDSGNY STE-Un_b_Smoe ---------VSMEQDARRIG---TLGAIVFNNFYV-------------------EKEGFV NIK_Hsap ARVCW-KGKR-------------------------------------------------- NIK_Mmus ARVCR-RGKR-------------------------------------------------- COT_Mmus ------------------------------------------------------------ COT_Hsap ------------------------------------------------------------ DDB0229972_Ddis NAVSKYKD---------------------------------------------------- DDB0229973_Ddis SNTIY-NG---------------------------------------------------- DDB0230010_Ddis VDVCL-M----------------------DWNE--------------------ELIPIP- IfkA_Ddis --SS-PMI-PYNFSFDSLNGFDPDIIFE---------------DSFQTPLKGSSSIDFEE CC1G_01579_Ccin ------------------------------------------------------------ AqueK223_Aque ASIL-EKV---------------------------------------------------- STE-Un_a_Smoe RTVDK-RG---------------------------------------------------- STE-Un_b_Smoe GGVAV-RGFL------------DCL--VNSWKEAGHKVKFIFFISGMTL----------- NIK_Hsap ------------------------------------------------------------ NIK_Mmus ------------------------------------------------------------ COT_Mmus ------------------------------------------------------------ COT_Hsap ------------------------------------------------------------ DDB0229972_Ddis ------------------------------------------------------------ DDB0229973_Ddis ------------------------------------------------------------ DDB0230010_Ddis ---------------------QNNNNHHNHNHHNNHTSGNFTG----------------- IfkA_Ddis MNNLTNSNNSNSTATTTTTTTTNNNNNNNTNNNNNNNSNNNNNNNNNNNNTNNNTNNNNN CC1G_01579_Ccin ------------------------------------------------------------ AqueK223_Aque ------------------------------------------------------------ STE-Un_a_Smoe ------------------------------------------------------------ STE-Un_b_Smoe ------------FECKSSG----------------------------------------- NIK_Hsap ------------------------------------------------------------ NIK_Mmus ------------------------------------------------------------ COT_Mmus ------------------------------------------------------------ COT_Hsap ------------------------------------------------------------ DDB0229972_Ddis --------------------G--------------------------------------- DDB0229973_Ddis --------------------E--------------------------------------- DDB0230010_Ddis ---------------------NINSNTTLSNSFFETLNSFNLREPLFDVCGKYQSSLQLS IfkA_Ddis NNNNNNNNNNNNNNNNNNNNNNSNNNNN-------------------------------- CC1G_01579_Ccin ------------------------------------------------------------ AqueK223_Aque --------------------K--------------------------------------- STE-Un_a_Smoe ------------------------------------------------------------ STE-Un_b_Smoe ------------------------------------------------------------ NIK_Hsap ------------------------------------------------------------ NIK_Mmus ------------------------------------------------------------ COT_Mmus --------------HLNVSEVIDIMENLYASEEPGVY----------------------- COT_Hsap --------------HLNVSDVIDIMENLYASEEPAVY----------------------- DDB0229972_Ddis ------------------------------------------------------------ DDB0229973_Ddis ------------------------------------------------------------ DDB0230010_Ddis GGSNLLNIPFSTLLNYNLNEQLNILVNNLNNSSPSSSSSSIKTKNTTSTTTTTTTTKNL- IfkA_Ddis -----------------------------------------------------ISNNKIN CC1G_01579_Ccin ------------------------------------------------------------ AqueK223_Aque ------------------------------------------------------------ STE-Un_a_Smoe ------------------------------------------------------------ STE-Un_b_Smoe ------------------------------------------------------------ NIK_Hsap --------------------------------------------------RSKARKK--- NIK_Mmus --------------------------------------------------HGKARKK--- COT_Mmus ------------------------------------------------------------ COT_Hsap ------------------------------------------------------------ DDB0229972_Ddis -------------------------------------------------TSSKSVKK--- DDB0229973_Ddis -------------------------------------------------EKTRDTIS--- DDB0230010_Ddis -----------------------------------------------------NDIS--- IfkA_Ddis KINNNNNNKELIDNNNNNKDKENDLINDTIPKIKWKKGSCIERKSNYSVYRGVDEDTDRK CC1G_01579_Ccin ------------------------------------------------------------ AqueK223_Aque -------------------------------------------------ERIQEEDD--- STE-Un_a_Smoe ------------------------------------------------------------ STE-Un_b_Smoe -------------------------------------------------MFPSARL---- NIK_Hsap ----------------------------------------------RKKKSSKSL----- NIK_Mmus ----------------------------------------------RRKKRSKSL----- COT_Mmus ------------------------------------------------------------ COT_Hsap ------------------------------------------------------------ DDB0229972_Ddis ----------------------------------------------TRRKFAMNI----- DDB0229973_Ddis ----------------------------------------------Y----NERP----- DDB0230010_Ddis ----------------------------------------------NNIN-NSRV----- IfkA_Ddis LICKIVNLNIDDRSSSSLTSLSNSNNNNSNNNNNNNNNNNNNNNNNNNNNNNNNL----- CC1G_01579_Ccin ------------------------------------------------------------ AqueK223_Aque -----------------------------------------------------EE----- STE-Un_a_Smoe ------------------------------------------------------------ STE-Un_b_Smoe -----------------------------------------------SKEEQSALSKLQV NIK_Hsap ------AHAGVAL----------------------------------------------- NIK_Mmus ------AQAGVAL----------------------------------------------- COT_Mmus ------------------------------------------------------------ COT_Hsap ------------------------------------------------------------ DDB0229972_Ddis ------ATDEVFN----------------------------------------------- DDB0229973_Ddis ------KRQTVGS----------------------------------------------- DDB0230010_Ddis -------LRSVSL----------------------------------------------- IfkA_Ddis ------SIDVVEL----------------------------------------------- CC1G_01579_Ccin ------------------------------------------------------------ AqueK223_Aque ------EPTSIRP----------------------------------------------- STE-Un_a_Smoe ------------------------------------------------------------ STE-Un_b_Smoe SSIKERRQGLAALVEFLLGGMHENGAENVIGQSVRGIVPSARDTAINWNTFHETGSDGVY NIK_Hsap -----------------------------------------------------AKPLP-- NIK_Mmus -----------------------------------------------------AKPLP-- COT_Mmus ---------------------------------------------------------EPS COT_Hsap ---------------------------------------------------------EPS DDB0229972_Ddis -----------------------------------------------------LPPME-- DDB0229973_Ddis -----------------------------------------------------STFFP-- DDB0230010_Ddis -----------------------------------------------------PPAPP-- IfkA_Ddis -----------------------------------------------------KKRLI-- CC1G_01579_Ccin ------------------------------------------------------------ AqueK223_Aque -----------------------------------------------------SRPTT-- STE-Un_a_Smoe ------------------------------------------------------------ STE-Un_b_Smoe ASSKCCGSFSVQNNGWLRLLEWLDRRFLERLLEEALLVVDSGGRGASKVVEAFLKVIE-- NIK_Hsap -----------------------R------------------------------------ NIK_Mmus -----------------------R------------------------------------ COT_Mmus LMTMYPDSNQNEERSESLLRSGQE------------------------------------ COT_Hsap LMTMCQDSNQNDERSKSLLLSGQE------------------------------------ DDB0229972_Ddis -----------------------Q------------------------------------ DDB0229973_Ddis -----------------------P------------------------------------ DDB0230010_Ddis -----------------------P------------------------------------ IfkA_Ddis -----------------------E------------------------------------ CC1G_01579_Ccin ------------------------------------------------------------ AqueK223_Aque -----------------------L------------------------------------ STE-Un_a_Smoe ------------------------------------------------------------ STE-Un_b_Smoe -----------------------VIPGEASSSIGAFLLTHLEDAVSSILDSVCRHSSAGK NIK_Hsap TPEQESCTIPVQEDESPL--GAPYVR---------------------------------- NIK_Mmus TPEQESCTIPVQEDESPL--GNLYAR---------------------------------- COT_Mmus ------------------------------------------------------------ COT_Hsap ------------------------------------------------------------ DDB0229972_Ddis QQQQQHLQPPLSPNSASN--TNFGA----------------------------------- DDB0229973_Ddis PPSRATSTSSIQVNSDPQEIEQLTEEQYLEMLEKRRQVSLQILQTEKEYAF--------- DDB0230010_Ddis PPTED--------PNSPW--SDPILW---------------------------------- IfkA_Ddis KV---KMIQKEIESMKYL--GNPYI-------------------------IKYLGTNFQE CC1G_01579_Ccin ------------------------------------------------------------ AqueK223_Aque SP---HAPPPKEEKNTPL--TPGTV----------------------------------- STE-Un_a_Smoe ------------------------------------------------------------ STE-Un_b_Smoe NSDQEMFSIHVEGKEGQD--SSREVE----NLEKMVH----------------------- NIK_Hsap ------------------------------------------------------------ NIK_Mmus ------------------------------------------------------------ COT_Mmus ---------------------------------------------------VPW------ COT_Hsap ---------------------------------------------------VPW------ DDB0229972_Ddis ------------------------------------------------------------ DDB0229973_Ddis ------------------------------------------------------------ DDB0230010_Ddis ------------------------------------------------------------ IfkA_Ddis GQNTLYIFQEYNSTLTLQQKILSNGIGFEESQVKKFTYQLLLGLLYLHSQHIPHRDFKSH CC1G_01579_Ccin ------------------------------------------------------------ AqueK223_Aque ------------------------------------------------------------ STE-Un_a_Smoe ------------------------------------------------------------ STE-Un_b_Smoe ------------------------------------------------------------ NIK_Hsap ------------------------------------------------------------ NIK_Mmus ------------------------------------------------------------ COT_Mmus ------------------------------------------------------------ COT_Hsap ------------------------------------------------------------ DDB0229972_Ddis ------------------------------------------------------------ DDB0229973_Ddis -------------------------YL--------------------------------- DDB0230010_Ddis ------------------------------------------------------------ IfkA_Ddis NIFFNQST----------SKMLLSNYG--------------------------------- CC1G_01579_Ccin ------------------------------------------------------------ AqueK223_Aque ------------------------------------------------------------ STE-Un_a_Smoe -------------------------------------------------SANELGESTDL STE-Un_b_Smoe -------LSNMLSAIVHGSSIAAAVFADLIAGTAVDAVIDLIQVYYFEGSRGEVSPCGDL NIK_Hsap ------------------------------------------------------------ NIK_Mmus ------------------------------------------------------------ COT_Mmus ------------------------------------------------------------ COT_Hsap ------------------------------------------------------------ DDB0229972_Ddis ------------------------------------------------------------ DDB0229973_Ddis ------------------------------------------------------------ DDB0230010_Ddis ------------------------------------------------------------ IfkA_Ddis ------------------------------------------------------------ CC1G_01579_Ccin ------------------------------------------------------------ AqueK223_Aque ------------------------------------------------------------ STE-Un_a_Smoe PL--------------------------------------------QSKQLTV----TEK STE-Un_b_Smoe PGEVLEQDRVMHSYPVVGAAPDASDEDHSATVAFCPFSSSGINAILQGQQVATFKSSCQS NIK_Hsap -------------------NTPQF--------------------------TKP------- NIK_Mmus -------------------NVSQF--------------------------TKP------- COT_Mmus ------------------------------------------------------------ COT_Hsap ------------------------------------------------------------ DDB0229972_Ddis ------------------AAT--------------------------------------- DDB0229973_Ddis -----------------NIIVEEF--------------------------LQP------- DDB0230010_Ddis ------------------------------------------------------------ IfkA_Ddis -----------------GRNIKIFDHFEKLNSLKNLNSWISSTNNSINNINNINNNNNNN CC1G_01579_Ccin ------------------------------------------------------------ AqueK223_Aque --------------------LRQY------------------------------------ STE-Un_a_Smoe AGTHAGST---HKRLGH-CPVEGN--------------------------PKP------- STE-Un_b_Smoe SGFAKVLLKLVLKRVGAVSTVKGF--------------------------PLP------- NIK_Hsap -------------------------LKE-------------------------------- NIK_Mmus -------------------------LGG-------------------------------- COT_Mmus ------------------------------------------------------------ COT_Hsap ------------------------------------------------------------ DDB0229972_Ddis ------------------------------------------------------------ DDB0229973_Ddis -------------------------LKNESNLSNNPFISKAQVKQLFGDTEVILGSSKLL DDB0230010_Ddis ------------------------------------------------------------ IfkA_Ddis NNNINTTTTQNQINNEIDRREDIINLG--------------------------------- CC1G_01579_Ccin ------------------------------------------------------------ AqueK223_Aque ------------------------------------------------------------ STE-Un_a_Smoe -------------------------SKR-------------------------------- STE-Un_b_Smoe -------------------------NGG-------------------------------- NIK_Hsap ---------------PGLGQLCF--------------------KQLGE------------ NIK_Mmus ---------------PGLGHLCF--------------------KKQDE------------ COT_Mmus ------------------------------------------------------------ COT_Hsap ------------------------------------------------------------ DDB0229972_Ddis ------------------------------------------------------------ DDB0229973_Ddis AEDLENVLLDGTSNPIGLGD-CF--------------------LKICDYFK--LYASYVK DDB0230010_Ddis ---------------MKWGD-CL--------------------FLLCTYLELPMYRATCE IfkA_Ddis --------------IVVLEM-LCGSDLANNQTVLIYLAQLNLLNN--------------- CC1G_01579_Ccin ------------------------------------------------------------ AqueK223_Aque ------------------------------------------------------------ STE-Un_a_Smoe ---------------RKAA----------------------------------------- STE-Un_b_Smoe ---------------RSGGKKTS--------------------LKASR------------ NIK_Hsap ------------------------------------------GLRPALPRSELHKLI--- NIK_Mmus ------------------------------------------GLRPVLPRPELHKLI--- COT_Mmus ------------------------------------------------------------ COT_Hsap ------------------------------------------------------------ DDB0229972_Ddis --------------------------------------------------------F--- DDB0229973_Ddis NYYTSISVLNKLKEESHKFQAFIQ----EKEQILLDSNFTDLGALLVLPVSRIGQYT--- DDB0230010_Ddis KYFKCIQILFKQQEKQHQQQQQQQQNQQDKEKFE-------------------------- IfkA_Ddis ---------------------------------------QQQNQNFIQPPPLQYQLQ--- CC1G_01579_Ccin ------------------------------------------------------------ AqueK223_Aque ------------------------------------------------------------ STE-Un_a_Smoe ------------------------------------------------------------ STE-Un_b_Smoe ------------------------------------------AFRLMLPRGGTKEVSSNS NIK_Hsap ------------------------------------------------------------ NIK_Mmus ------------------------------------------------------------ COT_Mmus ------------------------------------------------------------ COT_Hsap ------------------------------------------------------------ DDB0229972_Ddis ------------------------------------------------------------ DDB0229973_Ddis ------------------------------------------------------------ DDB0230010_Ddis ------------------------------------------------------------ IfkA_Ddis ------------------------------------------------------------ CC1G_01579_Ccin ------------------------------------------------------------ AqueK223_Aque ------------------------------------------------------------ STE-Un_a_Smoe ----------------------------------EKFSEVSYKYSKDSFCGF-------- STE-Un_b_Smoe TKASAVICHLLSAAAVMLTNRSSSLAQTRRKLVQEFKGP-RKLLLISSFVEELVRTVCDG NIK_Hsap SPLQC------------------------------------------------------- NIK_Mmus SPLQC------------------------------------------------------- COT_Mmus ------------------------------------------------------------ COT_Hsap ------------------------------------------------------------ DDB0229972_Ddis SPTSI------------------------------------------------------- DDB0229973_Ddis SMINY------------------------------------------------------- DDB0230010_Ddis ------------------------KQNNYNIKLLAIVLRKWGITLSRYSRRM-------- IfkA_Ddis QQYDL------------------------------------------------------- CC1G_01579_Ccin ------------------------------------------------------------ AqueK223_Aque ------------------------------------------------------------ STE-Un_a_Smoe ------------------------------------------------------------ STE-Un_b_Smoe SPEKAHEHIFQIIHVLDESDEHKSQGSRYPVLMLSEIQSRIKATLSDHKARVMENDGKQT NIK_Hsap ------------------------------------------------------------ NIK_Mmus ------------------------------------------------------------ COT_Mmus ------------------------------------------------------------ COT_Hsap ------------------------------------------------------------ DDB0229972_Ddis ------------------------------------------------------------ DDB0229973_Ddis ------------------------------------------------------------ DDB0230010_Ddis ------------------------------------------------------------ IfkA_Ddis ------------------------------------------------------------ CC1G_01579_Ccin ------------------------------------------------------------ AqueK223_Aque ------------------------------------------------------------ STE-Un_a_Smoe ------------------------------------------------------------ STE-Un_b_Smoe EQMVSLWEVWVALGSLLQVLSSFACKWPEEGGALLVFQRCGAEVGAVLHLLSSSEGPASW NIK_Hsap ------------------------------------------------------------ NIK_Mmus ------------------------------------------------------------ COT_Mmus ------------------------------------------------------------ COT_Hsap ------------------------------------------------------------ DDB0229972_Ddis ------------------------------------------------------------ DDB0229973_Ddis ------------------------------------------------------------ DDB0230010_Ddis ------------------------------------------------------------ IfkA_Ddis ------------------------------------------------------------ CC1G_01579_Ccin ------------------------------------------------------------ AqueK223_Aque ------------------------------------------------------------ STE-Un_a_Smoe ------------------------------------------------------------ STE-Un_b_Smoe GGGELLVMQNILRLFAICMQNSHCRQRELDNLLWNTLIDKNWEFIRRYSQWVVVDACHDC NIK_Hsap -----LN-----------------HVWKLH------------------------------ NIK_Mmus -----LN-----------------HVWKLH------------------------------ COT_Mmus ------------------------------------------------------------ COT_Hsap ------------------------------------------------------------ DDB0229972_Ddis -----LS-----------------KNNKI------------------------------- DDB0229973_Ddis -----LF-----------------SLTPQSHPDY-EPFKKAVIKMKSTVDYVKEKIRDND DDB0230010_Ddis ------KSQFLMSEWTSDENIQVEELWKVL------------------------------ IfkA_Ddis -----IK-----------------EIEQKTHPSSPISNNAKDFLSLCFTINGNGSTNDSL CC1G_01579_Ccin ------------------------------------------------------------ AqueK223_Aque -----------------------------NENPGHLPNHLKEYIE-----------KRAD STE-Un_a_Smoe ------------------------------------------------------------ STE-Un_b_Smoe TWDLLEE-----------------SLWSVW------------------------------ NIK_Hsap -----------HPQDGGPLPLPTH----------------------PFPYSRLPH----- NIK_Mmus -----------HPQATGPRPHPTH----------------------PFPYSGMPH----- COT_Mmus ------------------------------------------------------------ COT_Hsap ------------------------------------------------------------ DDB0229972_Ddis ------------------------------------------------------------ DDB0229973_Ddis SQNKVRIIQNQM----------TG----------------------KFENLNLPH----- DDB0230010_Ddis -----------HSQSIQSLLISNK----------------------ISP-SLVTQ----- IfkA_Ddis EAGILLKHP-FLASNSNSTPPPSNFLNFTNNIKFLDQRSAATQALLSSPHSLIPQPIQTL CC1G_01579_Ccin ------------------------------------------------------------ AqueK223_Aque A--IVQEVVPETPTSVQALPRPTH----------------------DVPRAELPH----- STE-Un_a_Smoe ------------------DDHLVD----------------------GFYDAGRDH----- STE-Un_b_Smoe -----------EPLEFRDLSDPTG----------------------DLFSSWLPR----- NIK_Hsap ------------------------------------------------------P----- NIK_Mmus ------------------------------------------------------P----- COT_Mmus ------------------------------------------------------------ COT_Hsap ------------------------------------------------------------ DDB0229972_Ddis ------------------------------------------------------------ DDB0229973_Ddis ------------------------------------------------------RRYVRE DDB0230010_Ddis ------------------------------------------------------------ IfkA_Ddis IKSQTPNNNNDNNNLASSNELLSSSNGSNIDLRSTNSSIVSNPLATSSSLDNITP----- CC1G_01579_Ccin ------------------------------------------------------------ AqueK223_Aque ------------------------------------------------------P----- STE-Un_a_Smoe ------------------------------------------------------P----- STE-Un_b_Smoe ------------------------------------------------------W----- NIK_Hsap -----------------------------FPFHPLQPWKPHPLE---------------- NIK_Mmus -----------------------------FPFYPLEPWKPYMLD---------------- COT_Mmus ------------------------------------------------------------ COT_Hsap ------------------------------------------------------------ DDB0229972_Ddis ------------------------------------------------------------ DDB0229973_Ddis GMLTESGKGSNSNQYYCFLFNDIFVLSTPI--------KKSNQF---------------- DDB0230010_Ddis -------------------------------YHLATAYHRHAITLNQFGCQSKEEIYGLI IfkA_Ddis -----------------------------PPSRPISP-KPSPLN---------------- CC1G_01579_Ccin ------------------------------------------------------------ AqueK223_Aque -----------------------------TPPIVHQT-S--------------------- STE-Un_a_Smoe -------------------------------FLPLEALENEQ-F---------------- STE-Un_b_Smoe -----------------------------LPSMQCEEIPVINLV---------------- NIK_Hsap -----------------SF---------------LGKLACVDS----------------- NIK_Mmus -----------------SA--------------VLDKLAGVSG----------------- COT_Mmus ------------------------------------------------------------ COT_Hsap ------------------------------------------------------------ DDB0229972_Ddis ------------------------------------------------------------ DDB0229973_Ddis -----------------SF---------------KKKISLSEA----------------- DDB0230010_Ddis TNSCKIYYETLLESLSDTF---------------LQQLQLQQQ----------------- IfkA_Ddis -----------------KR---------------NQKLQTSQQ----------------- CC1G_01579_Ccin --------------------------VEK------------------------------- AqueK223_Aque ------------------------------------------------------------ STE-Un_a_Smoe -----------------SFNRREVILVDRTKDEDLDAMASSAKQ---------------- STE-Un_b_Smoe -----------------SFLRLTIGLIQRKADREKNLLLPGKTRILLEFLMNPVTGLLMK NIK_Hsap ---------QK-----PLPD-PHLSKLACVDS---------------------------- NIK_Mmus ---------QR-----PLPGPPHLSQLAHGDS---------------------------- COT_Mmus ------------------------------------------------------------ COT_Hsap ------------------------------------------------------------ DDB0229972_Ddis ------------------------------------------------------------ DDB0229973_Ddis ---------EVTMISDPEDRPIFQISIQNIDS---------------------------- DDB0230010_Ddis ---------QQ-----P------------------------------------------- IfkA_Ddis ---------KP-----PL-SPPQTPLKQIPQS---------------------------- CC1G_01579_Ccin ------------------------------------------------------------ AqueK223_Aque ------------------------------------------------------------ STE-Un_a_Smoe ----------L-----LVSLGPGGATFEHGSSDLYNVAMLALFVSDCLGGSDKTLNVKIM STE-Un_b_Smoe LLKGDGFSKKK-----MIPQ------------KDYEAAFFHLKHVREDLRNLIPF--CT- NIK_Hsap ---------PKPLPGPHLEPSCLSRGAHEKFSVEEYLVHALQGSVSSGQ----------- NIK_Mmus ---------QKPLPGPHLESSCPSRGALEKVPVEEYLVHALQGSVSSGQ----------- COT_Mmus -----------------------------------------LSSVRYGT----------- COT_Hsap -----------------------------------------LSSVRYGT----------- DDB0229972_Ddis ------------------------------------------------------------ DDB0229973_Ddis ---------QQDN-SP-------------------------------------------- DDB0230010_Ddis ----------------------------------------WHDIEYYNNNEIFNDQFKSK IfkA_Ddis ---------PQSPPQQ-------------------------------------------- CC1G_01579_Ccin ------------------------------------------------------------ AqueK223_Aque ------------------------------------------------------------ STE-Un_a_Smoe RRTALGSTSSMPFVCSCCATG--------------------------------------- STE-Un_b_Smoe QRQGISGRVPHPVPASPQESTNRQQRG-----TERFGGNAVEGGQVSGP----------- NIK_Hsap ---------------------------AH---SLTSLAKTWAA---------------RG NIK_Mmus ---------------------------AH---SLASLAKTWSS---------------GS COT_Mmus ---------------------------VE---DLLAFANHVSN---------------MT COT_Hsap ---------------------------VE---DLLAFANHISN---------------TA DDB0229972_Ddis ------------------------------------------------------------ DDB0229973_Ddis ------------------------------------------------------------ DDB0230010_Ddis SLENWGRALDVQLSTKLNDEEETIEKEEE---DLNSVDEYLTT---------------FS IfkA_Ddis ------------------------------------------------------------ CC1G_01579_Ccin ------------------------------------------------------------ AqueK223_Aque ------------------------------------------------------------ STE-Un_a_Smoe ------------------------------------------------------------ STE-Un_b_Smoe ---------------------------ASVSYNLSYLAATNLEIASLQLLASIFGLSFHG NIK_Hsap SR-----SREPSPKTEDNEGV--------------------------------------- NIK_Mmus AK-----LQRLGPETEDNEGV--------------------------------------- COT_Mmus KH-----FY---GRRPQECGI--------------------------------------- COT_Hsap KH-----FY---GQRPQESGI--------------------------------------- DDB0229972_Ddis ------------------------------------------------------------ DDB0229973_Ddis ------------------------------------------------------------ DDB0230010_Ddis K--------S-------------------------------------------------- IfkA_Ddis ------------------------------------------------------------ CC1G_01579_Ccin ------------------------------------------------------------ AqueK223_Aque ------------------------------------------------------------ STE-Un_a_Smoe ------------------------------------------------------------ STE-Un_b_Smoe QRHRTTLSQSLLGRTAARNPFLGKAYAYPFLDFHFLRLIHLYYVNLLQGRKLKLAEPTLE NIK_Hsap ------------------------------------------------------------ NIK_Mmus ------------------------------------------------------------ COT_Mmus ------------------------------------------------------------ COT_Hsap ------------------------------------------------------------ DDB0229972_Ddis ------------------------------------------------------------ DDB0229973_Ddis ------------------------------------------------------------ DDB0230010_Ddis ------------------------------------------------------------ IfkA_Ddis ------------------------------------------------------------ CC1G_01579_Ccin -----------------------VRDK--ETG---------------------------- AqueK223_Aque ------------------------------------------------------------ STE-Un_a_Smoe -----------PSDSGASFSG--ALPSMRTLSDEAIRHVK-------------------- STE-Un_b_Smoe KVSENSCTLAWCSDNEAPCSEAEVRDE--QLSLECAVHVQVLLALAQNQSDDVTLRFKQL NIK_Hsap ------------------------------------------------------------ NIK_Mmus ------------------------------------------------------------ COT_Mmus ------------------------------------------------------------ COT_Hsap ------------------------------------------------------------ DDB0229972_Ddis ------------------------------------------------------------ DDB0229973_Ddis ------------------------------------------------------------ DDB0230010_Ddis ------------------------------------------------------------ IfkA_Ddis ------------------------------------------------------------ CC1G_01579_Ccin ------------------------------------------------------------ AqueK223_Aque ------------------------------------------------------------ STE-Un_a_Smoe --------------------LKRNSNV--------------------------------- STE-Un_b_Smoe RVMDFLVHQIALEYEASQVATPRDVVRINKALASQLRSSASSFRTKNVGDPSARTSETSH NIK_Hsap ------------------------------------------------------------ NIK_Mmus ------------------------------------------------------------ COT_Mmus ------------------------------------------------------------ COT_Hsap ------------------------------------------------------------ DDB0229972_Ddis ------------------------------------------------------------ DDB0229973_Ddis ------------------------------------------------------------ DDB0230010_Ddis ------------------VLKGV----TPSLEGVVSLCLNSKQALQYKA----------- IfkA_Ddis ------------------------------------------------------------ CC1G_01579_Ccin ------------------------------------------------------------ AqueK223_Aque ------------------------------------------------------------ STE-Un_a_Smoe -------------VPLGSLPYGVCRHRAILMKVCSKHCV------LY------------- STE-Un_b_Smoe PSMESSVSSDVTTPSVAGLKKGLCLL-SPELEGSNKSCL------VHKKLEKSLSKDMPK NIK_Hsap ------------------------------------------------------------ NIK_Mmus ------------------------------------------------------------ COT_Mmus ------------------------------------------------------------ COT_Hsap ------------------------------------------------------------ DDB0229972_Ddis ------------------------------------------------------------ DDB0229973_Ddis ------------------------------------------------------------ DDB0230010_Ddis INSVSVLCRSSEIVKSPIYNELMDQMTKVESFVSKRDDAESLLSQQKTLKSMPPKLQAYV IfkA_Ddis ------------------------------------------------------------ CC1G_01579_Ccin ------------------------------------------------------------ AqueK223_Aque ------------------------------------------------------------ STE-Un_a_Smoe ------------------------------------------------------------ STE-Un_b_Smoe LELGFLSARTLSAVQSSSCESY--------------------------LLSRPFT----- NIK_Hsap ------------------------------------------------------------ NIK_Mmus ------------------------------------------------------------ COT_Mmus ------------------------------------------------------------ COT_Hsap ------------------------------------------------------------ DDB0229972_Ddis ------------------------------------------------------------ DDB0229973_Ddis ------------------------------------------------------------ DDB0230010_Ddis RMSGLGEEEIMRNFEIAWNSIYFLTKDTIPNQPIPPNYYRSNKKNKLK------------ IfkA_Ddis ------------------------------------------------------------ CC1G_01579_Ccin ------------------------------------------------------------ AqueK223_Aque ------------------------------------------------------------ STE-Un_a_Smoe ------------------------------------------------------------ STE-Un_b_Smoe -----GRHEFL----QKWQEVM------KPAVPMHPVHEQASEKVAFPVTVDENNLAEDI NIK_Hsap ------------------------------------------------------------ NIK_Mmus ------------------------------------------------------------ COT_Mmus ------------------------------------------------------------ COT_Hsap ------------------------------------------------------------ DDB0229972_Ddis ------------------------------------------------------------ DDB0229973_Ddis ------NMLSLNGIQNAINNMTNNDSKS------------------K-NNNNNNSNGNN- DDB0230010_Ddis --------------QRQLNDSNNQDEKEEPEEIKPPLLPSIHRTNQLNNNNNNNNNINNN IfkA_Ddis ------N----------------------------------------------------- CC1G_01579_Ccin ------------------------------------------------------------ AqueK223_Aque ------------------------------------------------------------ STE-Un_a_Smoe ------------------------------------------------------------ STE-Un_b_Smoe EGDFAPEKVVYTGKFFDLNEEVERELAE------------------E--DGQDRPNSDN- NIK_Hsap ------------------------------------------------------------ NIK_Mmus ------------------------------------------------------------ COT_Mmus ------------------------------------------------------------ COT_Hsap ------------------------------------------------------------ DDB0229972_Ddis ------------------------------------------------------------ DDB0229973_Ddis --NNNNINSNSNSNNNS---------------------------------VIDIKSSGVL DDB0230010_Ddis NINNNNINNNKNGNSGGETPSPSSSFVITPFTSNSQSKFNTQRQFLSNSTLFNLSSSGIF IfkA_Ddis ------------------------------------------------------------ CC1G_01579_Ccin ------------------------------------------------------------ AqueK223_Aque ------------------------------------------------------------ STE-Un_a_Smoe ------------------------------------------------------------ STE-Un_b_Smoe --DSSDSESLTHS---------------------------------------EDDSIGSL NIK_Hsap ------------------------------------------------------------ NIK_Mmus ------------------------------------------------------------ COT_Mmus ------------------------------------------------------------ COT_Hsap ------------------------------------------------------------ DDB0229972_Ddis ------------------------------------------------------------ DDB0229973_Ddis INNGGGS---GFISNNNGITNVNSNNNNNNNINSNNNINGNNNNGNNSVNYSNGEDNN-- DDB0230010_Ddis TNNN---------NNNNGGSTITT-----------------TTTNNISPT---------- IfkA_Ddis --------------FNTPPTTTT------------------------------------- CC1G_01579_Ccin ------------------------------------------------------------ AqueK223_Aque ------------------------------------------------------------ STE-Un_a_Smoe ------------------------------------------------------------ STE-Un_b_Smoe ANEGGKASFRPFIPKLNLPRSARKGDQENSAEEAKPEIQ-VSKPGNKSPGVSLAGDGQTS NIK_Hsap ------------------------------------------------------------ NIK_Mmus ------------------------------------------------------------ COT_Mmus ------------------------------------------------------------ COT_Hsap ------------------------------------------------------------ DDB0229972_Ddis ----------------------------------------------------I------- DDB0229973_Ddis -DRECFTF-------------------------IADSNRDREDWIQAIH-ANIISSK--- DDB0230010_Ddis ---------------------------------------KTNGWTLTLP-SKAP-TRRAT IfkA_Ddis ------------------------------------TTTTPTATPTTPTMTPL------- CC1G_01579_Ccin ------------------------------------------------------------ AqueK223_Aque -------------------------------------------------QDIV------- STE-Un_a_Smoe ------------------------------------------------------------ STE-Un_b_Smoe GGSCKLTTPYEMERSQRRLYRNSSLHLFLLELYI---------------TLML------- NIK_Hsap ------------------------------------------------------------ NIK_Mmus ------------------------------------------------------------ COT_Mmus ------------------------------------------------------------ COT_Hsap ------------------------------------------------------------ DDB0229972_Ddis ----------TSQ----------------------------------------------- DDB0229973_Ddis ----------KRNE---------------------------------------------- DDB0230010_Ddis VSLININDLINQQ--------QQNQINSVSTLSQNNIILNNNNNLDNKPISKYIPN---- IfkA_Ddis ----------TPIQ-------KQ------------------------------------- CC1G_01579_Ccin -----------------------------AIVVRKSLSYEP------------------- AqueK223_Aque ----------YPIN-------EK---------------YL-------------------- STE-Un_a_Smoe ----------SRLV-------LQYLCDRSSPVIPCELVRGY---------LDYMPHAWNV STE-Un_b_Smoe ----------TPQGTLDQRYSDRFQTEKQKLNAPFFLFYRI------------------- NIK_Hsap -----------LLTEKLKPVDYE-YREEV------------------------------- NIK_Mmus -----------LLTEKLKPVDYE-YREEV------------------------------- COT_Mmus -----------LLNMVISPQNGR-YQIDS------------------------------- COT_Hsap -----------LLNMVITPQNGR-YQIDS------------------------------- DDB0229972_Ddis -------------------QTSSTSISPL------------------------------- DDB0229973_Ddis ---------------TRKPEDIE-KG-GI------------------------------- DDB0230010_Ddis ----------SIIRTTVNPPLLS-RCDE-------------------------------- IfkA_Ddis -----------------QQIDYDMFRYHS------------------------------- CC1G_01579_Ccin ------------------------------------------------------------ AqueK223_Aque ---------------HLGP-DGNYYEIRD------------------------------- STE-Un_a_Smoe VLVCRGGVNVRMLVDACRPLDIR-LESDPEYFCRFVSRFSIFVLFKQSFYFLSRYI-PTR STE-Un_b_Smoe -----------------------------------------------LFYLLAVLLWKTV NIK_Hsap --H-----WA-------------------------------------------THQLRLG NIK_Mmus --H-----WM-------------------------------------------THQPRVG COT_Mmus --DVLLVPWKLTY--------------------------------------RNIGSGFVP COT_Hsap --DVLLIPWKLTY--------------------------------------RNIGSDFIP DDB0229972_Ddis --K-----PSP----------------------------------------LSFSSGILP DDB0229973_Ddis --D-----FSVS---------------------------------------DIKLCEQIG DDB0230010_Ddis ------------TI-FSSGTPL----------------------------PLFRDKIKLG IfkA_Ddis --R-----YRT----------------------------------------DFEEIEMIG CC1G_01579_Ccin -----------------------------------------------------------G AqueK223_Aque ----------Y----------------------------------------DRVDNEILG STE-Un_a_Smoe RIH-----VQPRVVELGSGTFL----------------------------PLFYE--EIG STE-Un_b_Smoe QLD-----LHPDLNHVANSYLLPCLTERMKAFHHSAFRILRLSWRGLFNSSLYRNRIRIA NIK_Hsap R-----------GSFG-EVHRMEDKQ-TGFQC-AVKK--VRLE-------------VF-- NIK_Mmus R-----------GSFG-EVHRMKDKQ-TGFQC-AVKK--VRLE-------------VF-- COT_Mmus R-----------GAFG-KVYLAQDMK-TKKRM-ACKL--IPID-------------QF-- COT_Hsap R-----------GAFG-KVYLAQDIK-TKKRM-ACKL--IPVD-------------QF-- DDB0229972_Ddis PSSRIYESPPTLGKYD-KVILVILSQ-QYLQN-QVNI--FPIKLIDRERINLIH-QNI-- DDB0229973_Ddis S-----------GGSGCTVHRCT--V-DGFTC-AVKV--LKLK--NTS---PFLVEQF-- DDB0230010_Ddis T-----------GAFG-NVFYAIRKS-DSSPV-AIKV--LMER--T-------KKDSP-- IfkA_Ddis K-----------GGFG-VVVKSRNKL-DCRYY-AIKK--IKTK--GYTDSNQEPLTNK-- CC1G_01579_Ccin N-----------AASGP---------------------------------------GD-- AqueK223_Aque E-----------GGFG-TVYACSDRY-YQTMF-AIKC--NKHN--SEE-----KVRNM-- STE-Un_a_Smoe F-----------GASGAEVRKCSIRQLDS----AVVK--ESSD-------------GG-- STE-Un_b_Smoe H-----------GAFAQ-IYK-ATVNEEDGPRLVVLKTVELPK-------------GPYE . NIK_Hsap ------RAEELMAC-AG-LT-SPRIVPLYGAVR--------------------------- NIK_Mmus ------RVEELVAC-AG-LS-SPRIVPLYGAVR--------------------------- COT_Mmus ------KPSDVEIQ-AC-FR-HENIAELYGAVL--------------------------- COT_Hsap ------KPSDVEIQ-AC-FR-HENIAELYGAVL--------------------------- DDB0229972_Ddis ------LSNEFQLL-KSL-K-HSGIVNYIGMI---------------------------- DDB0229973_Ddis -------ISEITIM-VK-LS-HQNIAKYLGHR---------------------------- DDB0230010_Ddis ------IIPELYIH-SA-CN-HSNIVTYIESYL--------------------------- IfkA_Ddis ------LLREVTTL-SRL-H-HQFVVRYYQAWIEKSCDSFQSLEEGNEDLSGDLETDASE CC1G_01579_Ccin ------VIDELKRFT-H-LR-HTNIIIIHGWYLSR------------------------- AqueK223_Aque ------NL-ECRVL-DHIGH-HTHITQLFGAMIDKNVSA--------------------- STE-Un_a_Smoe ------WLSELRIHCSI-GE-HPNVVAFYGHQLSFESAAS--NG---------------- STE-Un_b_Smoe PCKFFDVYSEVQILE-K-FLGEPKISQLLDYGLES------------------------- : : NIK_Hsap ------------------------------------------------------------ NIK_Mmus ------------------------------------------------------------ COT_Mmus ------------------------------------------------------------ COT_Hsap ------------------------------------------------------------ DDB0229972_Ddis ------------------------------------------------------------ DDB0229973_Ddis ------------------------------------------------------------ DDB0230010_Ddis ------------------------------------------------------------ IfkA_Ddis DWFMQSSINSRSIISRDSYSGLSTSNSNVGGVNNTAGGGDSVSNANSNKSMIVGNSNKKL CC1G_01579_Ccin ------------------------------------------------------------ AqueK223_Aque ------------------------------------------------------------ STE-Un_a_Smoe ------------------------------------------------------------ STE-Un_b_Smoe ------------------------------------------------------------ NIK_Hsap ------------------------------------------------------------ NIK_Mmus ------------------------------------------------------------ COT_Mmus ------------------------------------------------------------ COT_Hsap ------------------------------------------------------------ DDB0229972_Ddis ------------------------------------------------------------ DDB0229973_Ddis ------------------------------------------------------------ DDB0230010_Ddis ------------------------------------------------------------ IfkA_Ddis TLSSSNTSSSSSLLSNNKSKILNTSKSTSTNTSTSTSTSNTNKNKKISKKKKSKLSPLMK CC1G_01579_Ccin ------------------------------------------------------------ AqueK223_Aque ------------------------------------------------------------ STE-Un_a_Smoe ------------------------------------------------------------ STE-Un_b_Smoe ------------------------------------------------------------ NIK_Hsap ------------------------------------------------------------ NIK_Mmus ------------------------------------------------------------ COT_Mmus ------------------------------------------------------------ COT_Hsap ------------------------------------------------------------ DDB0229972_Ddis ------------------------------------------------------------ DDB0229973_Ddis ------------------------------------------------------------ DDB0230010_Ddis ------------------------------------------------------------ IfkA_Ddis PKNKKNKNNGESEQSSSDSENGENGMKSRIIENASDSYSDDDNNNNNNNDNNNNYHSDNE CC1G_01579_Ccin ------------------------------------------------------------ AqueK223_Aque ------------------------------------------------------------ STE-Un_a_Smoe ------------------------------------------------------------ STE-Un_b_Smoe ------------------------------------------------------------ NIK_Hsap ------------------------------------------------------------ NIK_Mmus ------------------------------------------------------------ COT_Mmus ------------------------------------------------------------ COT_Hsap ------------------------------------------------------------ DDB0229972_Ddis ------------------------------------------------------------ DDB0229973_Ddis ------------------------------------------------------------ DDB0230010_Ddis ------------------------------------------------------------ IfkA_Ddis SDSFSGSISMSDGNGSGYEATDDEDIINNSGSFDENENDDDDEEDDDDEYDEEDDDYETF CC1G_01579_Ccin ------------------------------------------------------------ AqueK223_Aque ------------------------------------------------------------ STE-Un_a_Smoe ------------------------------------------------------------ STE-Un_b_Smoe ------------------------------------------------------------ NIK_Hsap --------------------------EGPWVNIFMELLEGGSLGQLV------KE----- NIK_Mmus --------------------------EGPWVNIFMELLEGGSLGQLI------KQ----- COT_Mmus --------------------------WGDTVHLFMEAGEGGSVLEKL------ES----- COT_Hsap --------------------------WGETVHLFMEAGEGGSVLEKL------ES----- DDB0229972_Ddis -------------------------NDNTGFGIVQEFYENGSLSDIY------N------ DDB0229973_Ddis -------------------------LSGNQLWLFMEFYPHS-LKDVI------TK----- DDB0230010_Ddis --------------------------CKGHVWIILEYCDGGTVRDLL------QATCTPG IfkA_Ddis DFQDKSRVVSNNSKLSTSSSRKKPPKETHTLYIQMEYCSKKTLKTLI------D------ CC1G_01579_Ccin ---------------------------WGLPRVLMEYCEGGSLESIN------ERI---- AqueK223_Aque -----------------------CVYEGQKFKMLMELATNGSLDELL------FDPDT-- STE-Un_a_Smoe ------------------AN---KKLDAPQLVIFMEYVKGGSLDNVI------TRF---- STE-Un_b_Smoe ----------------------------ETFVLVLKHYKCSLRAWRLNQGGLHSHK---- : : NIK_Hsap ----QG--CLPEDRALYYLGQALEGLEYLHSRR--ILHGDVKADNVLLSSDGS------- NIK_Mmus ----MG--CLPEDRALYYLGQALEGLEYLHTRR--ILHGDVKADNVLLSSDGS------- COT_Mmus ----CG--PMREFEIIWVTKHILKGLDFLHSKK--VIHHDIKPSNIVFMST--------- COT_Hsap ----CG--PMREFEIIWVTKHVLKGLDFLHSKK--VIHHDIKPSNIVFMST--------- DDB0229972_Ddis ---RSG--AFQESLVAKYTLQILEALGYIHSQG--IVHRNLKSNNVLLAKGG-------- DDB0229973_Ddis ---RTS--PFPATEVIWMALEIAKGLEFLHTQKNPIIHRDLKPGNIMCSLDDKG------ DDB0230010_Ddis NPNNLQ--LFEETLIAYIITELLEGLVYLRSKG--IIHRDLKSRNILLTRKG-------- IfkA_Ddis ---NVG--GIAEEEAFRLLRQIVEGLNHIHSQQ--IIHRDLKPANIFIDNEQ-------- CC1G_01579_Ccin --IEKNVT-VEERIAGQVAEGILQGLSYLFSQD--LIHNSLEPANILFSKGGL------- AqueK223_Aque --NEPS--GLPFNQSLFYLQQILYAVHFLHQRA--ILHLDLKCANVLLFNEGR------- STE-Un_a_Smoe --SKDGCLYTPPRLAINIAESVAQGLVWLHSRG--IIHRDIKSSNILVDLDSPD------ STE-Un_b_Smoe --SGKSFV-DRLPLYLEVYAAVLDAVKVLEAHN--VVHYDLKCDNVLLEPVDSVISEEEF .: : : ::* .:: *:. NIK_Hsap -----------------HAALCDFGHAV-CLQPDGLGKSLL------------------- NIK_Mmus -----------------RAALCDFGHAL-CLQPDGLGKSLL------------------- COT_Mmus -----------------KAVLVDFGLSV-KMTEDV------------------------- COT_Hsap -----------------KAVLVDFGLSV-QMTEDV------------------------- DDB0229972_Ddis -----------------KVKISDFAIGI-RSSAI-------------------------- DDB0229973_Ddis --------------RVCSIRVCDFDTSK-ELGN--------------------------- DDB0230010_Ddis -----------------KVKIADFGLAT-TCSL--------------------------- IfkA_Ddis -----------------NVKIGDFGLAT-SGAPVSKSDDLNSSTSNTANNINLSSSTNST CC1G_01579_Ccin ------------------VKLSGHPWAE-IVHQGA------------------------- AqueK223_Aque -----------------TVKLTDFGSAV-RLDESG------------------------- STE-Un_a_Smoe --------------NRPVVKICDFDSAV-PVGSSSIHTCYL------------------- STE-Un_b_Smoe WDPTWPPSEENSHPLPFRVCLADFGQSKASVFQGG------------------------- : .. . NIK_Hsap ---------------TGDYIPGTETHMAPEVVLGRS-----------CDAKVDVWSSCCM NIK_Mmus ---------------TGDYIPGTETHMAPEVVMGKP-----------CDAKVDIWSSCCM COT_Mmus --------------YLPKDLRGTEIYMSPEVILCR-----------GHSTKADIYSLGAT COT_Hsap --------------YFPKDLRGTEIYMSPEVILCR-----------GHSTKADIYSLGAT DDB0229972_Ddis ------------EPSIRFSLNGYPFWTSPEVLSM-----K------PFNHKVDSWSIGCL DDB0229973_Ddis ------------GVTLKTC-IGTPCYMAAEVLNVADGGNS------GYSLKADIWSFAML DDB0230010_Ddis ------------GRGRTR-MCGTMGRIAPEVIRRE-----------PYDTQSDIYSLGCL IfkA_Ddis AQQTPMWDLNDENLSMTGGV-GTPFYCCPEILEKN---TK------HYGTKVDMYSLGII CC1G_01579_Ccin ------------------HTSRRLYYMSPEQIQGLAT-S---------RGPSDIWSAGVV AqueK223_Aque ------------GCHIQSNKGLTPYFSAPEAIRC-----E------YVSFSADIWSVLCC STE-Un_a_Smoe ---------AHHGLPLTDVCVGTPRWIAPEVLGAMYT-RQ------QYGLEADMWSFGCF STE-Un_b_Smoe -------------ECTV-RNRGTEYVKSPEMLKLLRT-GGDASLDTCVGKAVDVWGLGCL ..* : * :. NIK_Hsap MLHMLNGCHPWTQ-----FFR-G--PLCLKI----------------AS-EPPPVREI-- NIK_Mmus MLHMLNGCHPWTQ-----YFR-G--PLCLKI----------------AS-EPPPIREI-- COT_Mmus LIHMQTGTPPWVK-----RYPRSAYPSYLYII---------------HK-QAPPLEDI-- COT_Hsap LIHMQTGTPPWVK-----RYPRSAYPSYLYII---------------HK-QAPPLEDI-- DDB0229972_Ddis IMELIVGHPPFSH-----LGPM---EALIEII---------------NP-STTILP---- DDB0229973_Ddis CFEIISLLPPYHQ-----FQ--HLQ-SIEMII---------------NG-TCPPLPT--- DDB0230010_Ddis IIEMAEGTVPYGK-----DS--SLKALFYTAI---------------HQ-YKLPNPK--- IfkA_Ddis FFEMCFQFQT--------QMERSNILRDLRDN---------------L-KFPPGFE---- CC1G_01579_Ccin LLEFVQKEFPWGS-----DL--SPVEIMMNIV---------------HG-EPPTLADK-- AqueK223_Aque LVEMITGHLPWCY-----NGLRDPHNIIMLAG---------------HYCDAEPLKYF-- STE-Un_a_Smoe ISELLTLNVPYAG-----IGDNEIHNHIKVSVVVTILSSPSHALVGQAG-ERPSLTWKLD STE-Un_b_Smoe LYELLAAEYLLYDEDWMRFFIRVTTNSEELIT---------------NE-KAEK------ .: NIK_Hsap -------PP---SCAPLTAQAIQEGLRKEPIHRVSAAELGGKVNRALQQVGGLKSPWRGE NIK_Mmus -------PP---SCAPLTAQAIQEGLRKEPVHRASAMELRRKVGKALQEVGGLKSPWKGE COT_Mmus -------AG---DCSPGMRELIEAALERNPNHRPKAADLLKHEAL-------------NP COT_Hsap -------AD---DCSPGMRELIEASLERNPNHRPRAADLLKHEAL-------------NP DDB0229972_Ddis NCLDE--N-EQSLFSLELNQFLELCFKKEPSDRASVHDLLRHPWL-------------SM DDB0229973_Ddis ----D--L-IQPKLLQPLIELLVTCIDLNPNHRPNASQLVQKLT---------------- DDB0230010_Ddis ------------KYTKEFVDFLYLCLNPDPFKRPTPEMLLHHTFL-------------SG IfkA_Ddis ------------STKPDQTQIIRSLLSRDPTQRPSTKQLLESGLL-------------PS CC1G_01579_Ccin -------TTDDAVWSNDLKDFLKQMLVNAPSGRKTAMELLEHSWI--------------- AqueK223_Aque RCLVP--E-GIETEDPRILELFEKVFKRNPKDRPTALKLLEHELI-------------KD STE-Un_a_Smoe EIVLEPAVGGDKDCLDALIRLYESCTELDPGKRPTAQEALSSLQ---------------- STE-Un_b_Smoe -------VG----NFGPVVEFIRFVLVRDPCRRPTLDEVMIHLRQLQ------------- * * NIK_Hsap YKEPRHPPPN-QANYH-------------------------------------------- NIK_Mmus YKEPRPPPQD-QATCH-------------------------------------------- COT_Mmus ------------------------------------------------------------ COT_Hsap ------------------------------------------------------------ DDB0229972_Ddis FNDSSSSSSSSSSQAHPTVQSNNLNGNVNSRTHGEFYSLDFLSQFEQNEKEISKILSSGD DDB0229973_Ddis ------------------------------------------------------------ DDB0230010_Ddis ------------------------------------------------------------ IfkA_Ddis KMEDDILKEAIKTIAN-------------------------------------------- CC1G_01579_Ccin ------------------------------------------------------------ AqueK223_Aque AHEYEKEFD--------------------------------------------------- STE-Un_a_Smoe ------------------------------------------------------------ STE-Un_b_Smoe ------------------------------------------------------------ NIK_Hsap ------------------------------------------------------------ NIK_Mmus ------------------------------------------------------------ COT_Mmus ------------------------------------------------------------ COT_Hsap ------------------------------------------------------------ DDB0229972_Ddis QLDSTSNQIDLKKFQFKHYNKKQQQQYNYNYNNYNNNNNNNNNTNDNDNECGEQTEEINL DDB0229973_Ddis ------------------------------------------------------------ DDB0230010_Ddis ------------------------------------------------------------ IfkA_Ddis -----------------------------------------------------P------ CC1G_01579_Ccin ------------------------------------------------------------ AqueK223_Aque -----------------------------------------------------QYEDIDG STE-Un_a_Smoe ------------------------------------------------------------ STE-Un_b_Smoe ------------------------------------------------------------ NIK_Hsap QTLHAQPR-------------------------------ELSPRAP-GPRPAEE------ NIK_Mmus QTLPTPPR-------------------------------ENPPAKA-------------- COT_Mmus ------PR-------------------------------EDQPRCQ-SLDSAL------- COT_Hsap ------PR-------------------------------EDQPRCQ-SLDSAL------- DDB0229972_Ddis SSL-SKDEQIERLKAIIDQNETMANNLKYTMQEVLQEQTKYYEICE-SMKSKTLEI---- DDB0229973_Ddis ------------------------------------------------------------ DDB0230010_Ddis ------AD-------------------------------RG--------KSILLGRFKNQ IfkA_Ddis --------------------------------------------T-ISLFSYLMEKLF-C CC1G_01579_Ccin ----KSVI-------------------------------AQ------------------- AqueK223_Aque EVL-APPE-------------------------------AATPTSNDKVESNASGGSK-K STE-Un_a_Smoe ------------------------------------------------------------ STE-Un_b_Smoe ESL-GRPK-------------------------------TK------------------- NIK_Hsap -TTGRAPK--------------------------------------LQPPLPPEPPEPNK NIK_Mmus -NTDGAPE--------------------------------------PQPPLPPEPPEPSK COT_Mmus ------------------------------------------------------------ COT_Hsap ------------------------------------------------------------ DDB0229972_Ddis ------------------------------------------------------------ DDB0229973_Ddis ------------------------------------------------------------ DDB0230010_Ddis D----------------------------------------------------------- IfkA_Ddis LSNDEHIMSRYLYTSNPSLTPMHLICREKTFSRLEKIFLNHGSIRIDTPTLFPKNPTNST CC1G_01579_Ccin ------------------------------------------------------------ AqueK223_Aque SSRASV--------------------------DSG--------------MDTERSSSNSS STE-Un_a_Smoe ------------------------------------------------------------ STE-Un_b_Smoe ------------------------------------------------------------ NIK_Hsap SP-PLTLS--KEESGMWEPLPLS------------------------------------- NIK_Mmus AP-ALNLS--KEESGTWEPLPLS------------------------------------- COT_Mmus ------------------------------------------------------------ COT_Hsap ------------------------------------------------------------ DDB0229972_Ddis ------LN--QNKTGARISAHSNSLL---------------------------------- DDB0229973_Ddis --------KM-------------------------------------------------- DDB0230010_Ddis ------------------------------------------------------------ IfkA_Ddis HPGAANVAKFLDESGTVVYLPYDLTIPWARHVVIHNIQQAKRYTFSKVYRRSQPGFSPKE CC1G_01579_Ccin ------------------------------------------------------------ AqueK223_Aque SPGSA--TEL-------------------------------------------------- STE-Un_a_Smoe ------------------------------------------------------------ STE-Un_b_Smoe ------------------------------------------------------------ NIK_Hsap ------------------------------------------------------------ NIK_Mmus ------------------------------------------------------------ COT_Mmus ------------------------------------------------------------ COT_Hsap ------------------------------------------------------------ DDB0229972_Ddis ------------------------------------------------------------ DDB0229973_Ddis ------------------------------------------------------------ DDB0230010_Ddis ------------------------------------------------------------ IfkA_Ddis LYECDFDIIGPSKSRHISDAETLRIIIEIMEEFKDELFGNNSGSNSGSGSGGSINYKIRI CC1G_01579_Ccin ------------------------------------------------------------ AqueK223_Aque ------------------------------------------------------------ STE-Un_a_Smoe ------------------------------------------------------------ STE-Un_b_Smoe ------------------------------------------------------------ NIK_Hsap ------------------------------------------------------------ NIK_Mmus ------------------------------------------------------------ COT_Mmus ------------------------------------------------------------ COT_Hsap ------------------------------------------------------------ DDB0229972_Ddis ------------------------------------------------------------ DDB0229973_Ddis ------------------------------------------------------------ DDB0230010_Ddis ------------------------------------------------------------ IfkA_Ddis NHYGLLDSILSECGVEKRFFTVVYQTVAQLHWRLNWAQVAQSLKEHGLSASIVSNISTYF CC1G_01579_Ccin ------------------------------------------------------------ AqueK223_Aque ------------------------------------------------------------ STE-Un_a_Smoe ------------------------------------------------------------ STE-Un_b_Smoe ------------------------------------------------------------ NIK_Hsap ------------------------------------------------------------ NIK_Mmus ------------------------------------------------------------ COT_Mmus ------------------------------------------------------------ COT_Hsap ------------------------------------------------------------ DDB0229972_Ddis ------------------------------------------------------------ DDB0229973_Ddis ------------------------------------------------------------ DDB0230010_Ddis ------------------------------------------------------------ IfkA_Ddis RQRGELAQCVTQLESLLANHKEATTGISDLKILVRNLQMINIIPRFLLDLSLIHNHQYYE CC1G_01579_Ccin ------------------------------------------------------------ AqueK223_Aque ------------------------------------------------------------ STE-Un_a_Smoe ------------------------------------------------------------ STE-Un_b_Smoe ------------------------------------------------------------ NIK_Hsap ---------------------------------SLEP----------------------- NIK_Mmus ---------------------------------SLDP----------------------- COT_Mmus ------------------------------------------------------------ COT_Hsap ------------------------------------------------------------ DDB0229972_Ddis ------------------------------------------------------------ DDB0229973_Ddis ------------------------------------------------------------ DDB0230010_Ddis ------------------------------------------------------------ IfkA_Ddis GLVFQAYIERPTLSNPSRTEIIMSGGRYDKLIKSLHPNPSLSNNIVSGVGVTLACEKIVN CC1G_01579_Ccin ------------------------------------------------------------ AqueK223_Aque ------------------------------------------------------------ STE-Un_a_Smoe ------------------------------------------------------------ STE-Un_b_Smoe ------------------------------------------------------------ NIK_Hsap --------------------------APARNPSSPERKATVPEQELQQLEIELFL----- NIK_Mmus --------------------------ATAKGPSFPDRRATLPELELQQLEIELFL----- COT_Mmus ----------------------------------FERKRLLSRKELQLPE---NI----- COT_Hsap ----------------------------------LERKRLLSRKELELPE---NI----- DDB0229972_Ddis -------------------------KRTNQMANDLGRKYEILQSNIKRLEDYLITKDDCA DDB0229973_Ddis ------------------------------------------------------------ DDB0230010_Ddis ------------------------------------------------------------ IfkA_Ddis SVLNYRQHLLNNCFNTTYTRRNKDPPNSNNNPNNNNLNNNVSIFTKFQSHIEVFV----- CC1G_01579_Ccin ------------------------------------------------------------ AqueK223_Aque ------------------------------------------------------------ STE-Un_a_Smoe ------------------------------------------------------------ STE-Un_b_Smoe ------------------------------------------------------------ NIK_Hsap --------------NSLSQPF--------------------------------------- NIK_Mmus --------------NSLSQPF--------------------------------------- COT_Mmus --------------ADSSCTG--------------------------------------- COT_Hsap --------------ADSSCTG--------------------------------------- DDB0229972_Ddis KKLANVVYRNKISFDSLLNPTLAANLLYQIGSKTWKKGQEKRAFATLKDNFLFFFKNEKS DDB0229973_Ddis ------------------------------------------------------------ DDB0230010_Ddis ------------------------------------------------------------ IfkA_Ddis --------------CSL------------------------------------------- CC1G_01579_Ccin ------------------------------------------------------------ AqueK223_Aque ------------------------------------------------------------ STE-Un_a_Smoe ------------------------------------------------------------ STE-Un_b_Smoe ------------------------------------------------------------ NIK_Hsap ------SLEEQEQILSCLSIDSLS----LSDDSE----------KNP------------- NIK_Mmus ------SLEEQEQILSCLSIDSLS----LSDDSE----------KNP------------- COT_Mmus ------STEESEV----------------------------------------------- COT_Hsap ------STEESEM----------------------------------------------- DDB0229972_Ddis SYPIDVIYLNDKRNISITSI---QDSKKKAYIICIGTTIHDQNNLDPSNNNESVNLSTSP DDB0229973_Ddis ------------------------------------------------------------ DDB0230010_Ddis ------------------------------------------------------------ IfkA_Ddis ------------------------------------------------------------ CC1G_01579_Ccin ------------------------------------------------------------ AqueK223_Aque ------------------------------------------------------------ STE-Un_a_Smoe ------------------------------------------------------------ STE-Un_b_Smoe ------------------------------------------------------------ NIK_Hsap ------------------------------------------------------------ NIK_Mmus ------------------------------------------------------------ COT_Mmus ------------------------------------------------------------ COT_Hsap ------------------------------------------------------------ DDB0229972_Ddis GSLVNSNSNPSISNSLNNNNNNNNNNNNNNNGNPNVIITTNNNCNSNSNGNNIATPPISI DDB0229973_Ddis ------------------------------------------------------------ DDB0230010_Ddis ------------------------------------------------------------ IfkA_Ddis ------------------------------------------------------------ CC1G_01579_Ccin ------------------------------------------------------------ AqueK223_Aque ------------------------------------------------------------ STE-Un_a_Smoe ------------------------------------------------------------ STE-Un_b_Smoe ------------------------------------------------------------ NIK_Hsap -----------------------------------------SKASQSSRDT--------- NIK_Mmus -----------------------------------------SKASQSSRDT--------- COT_Mmus ------------------------------------------------------------ COT_Hsap ------------------------------------------------------------ DDB0229972_Ddis PNGKEVKEGKEIKEIKEPKEKDKDKEKDKDKEKDKDKEKDKDKEKEKDKDKENNNNNNSN DDB0229973_Ddis ------------------------------------------------------------ DDB0230010_Ddis -----------------------------------------------TR----------- IfkA_Ddis ------------------------------------------------------------ CC1G_01579_Ccin ------------------------------------------------------------ AqueK223_Aque ------------------------------------------------------------ STE-Un_a_Smoe ------------------------------------------------------------ STE-Un_b_Smoe ------------------------------------------------------------ NIK_Hsap ------------------------------------------------------------ NIK_Mmus ------------------------------------------------------------ COT_Mmus ------------------------------------------------------------ COT_Hsap ------------------------------------------------------------ DDB0229972_Ddis NNNNNGNNYNSSETIWCLLAFDNSKNMENWYGVLDSVVPWYDKRAYEISKPMLPIENKKH DDB0229973_Ddis ------------------------------------------------------------ DDB0230010_Ddis ------------------------------------------------------------ IfkA_Ddis -----------------GSSLLGEKLQVASQLWSAGIKADYSQTDYYSSEDIYSNCRENG CC1G_01579_Ccin ------------------------------------------------------------ AqueK223_Aque ------------------------------------------------------------ STE-Un_a_Smoe ------------------------------------------------------------ STE-Un_b_Smoe ------------------------------------------------------------ NIK_Hsap ------------------------------------------------------------ NIK_Mmus ------------------------------------------------------------ COT_Mmus -----LRRQRSLYI---------------------------------------------- COT_Hsap -----LKRQRSLYI---------------------------------------------- DDB0229972_Ddis QKQKSLDSTNKQSPGS-------------------------------------------- DDB0229973_Ddis ------------------------------------------------------------ DDB0230010_Ddis ------------------------------------------------------------ IfkA_Ddis IPWVVILREKAFQIGKLKVKQIETRQERTVARKDLVDFFLKSRKHNVDSKNIIQNTSSSD CC1G_01579_Ccin ------------------------------------------------------------ AqueK223_Aque -----IDSKASFSIGTLPVP---------------------------------------- STE-Un_a_Smoe ------------------------------------------------------------ STE-Un_b_Smoe ------------------------------------------------------------ NIK_Hsap ------------------------------------------------------------ NIK_Mmus ------------------------------------------------------------ COT_Mmus ------------------------------------------------------------ COT_Hsap ------------------------------------------------------------ DDB0229972_Ddis ------------------------------------------------------------ DDB0229973_Ddis ------------------------------------------------------------ DDB0230010_Ddis ------------------------------------------------------------ IfkA_Ddis LSNLIGGINNSGSGGSGGSGGGSSMSSGGGGGGNSNIGGSDHHHHGHHSNQSTSSSGNSN CC1G_01579_Ccin ------------------------------------------------------------ AqueK223_Aque ----GG------------------------------------------------------ STE-Un_a_Smoe ------------------------------------------------------------ STE-Un_b_Smoe ------------------------------------------------------------ NIK_Hsap -----------------------LSSGVHSWSSQAEARSSS----------------WNM NIK_Mmus -----------------------LSSGVHSWNSQAEARTCS----------------CST COT_Mmus ------------------------------------------------------------ COT_Hsap ------------------------------------------------------------ DDB0229972_Ddis ---------------------LGGAGGDVS----------WKKESGGIKFQGVVGVRLDD DDB0229973_Ddis ------------------------------------------------------------ DDB0230010_Ddis ------------------------------------------------------------ IfkA_Ddis NSNTQQTSPIQHHVHFSNTKSIIGSSGIISNATFSGGSSSS-----------------SN CC1G_01579_Ccin ------------------------------------------------------------ AqueK223_Aque ----------------------------------------------------------AS STE-Un_a_Smoe ------------------------------------------------------------ STE-Un_b_Smoe ------------------------------------------------------------ NIK_Hsap VLARGRPTDTPS---YFNGV---------------------------------------- NIK_Mmus ALARGRPTDIPS---YFNGV---------------------------------------- COT_Mmus ------------------------------------------------------------ COT_Hsap ------------------------------------------------------------ DDB0229972_Ddis LMTRESPTAELP---YFLSKMLKFLEKNVDEEGILRLSGSSTEILEMKQQLQRGESIDYT DDB0229973_Ddis ------------------------------------------------------------ DDB0230010_Ddis ------------------------------------------------------------ IfkA_Ddis IIHFDEPTDSFSTQIVYQGVE-EI------------------------------------ CC1G_01579_Ccin ------------------------------------------------------------ AqueK223_Aque DC-PPPPHPP-------------------------------------------------- STE-Un_a_Smoe ------------------------------------------------------------ STE-Un_b_Smoe ------------------------------------------------------------ NIK_Hsap ---------------KVQIQSLNGEHLHIR------------------------------ NIK_Mmus ---------------KVQIQSLNGEHLHIR------------------------------ COT_Mmus --D--------------------------------------------------------- COT_Hsap --D--------------------------------------------------------- DDB0229972_Ddis YKDPHAVTGLLKLFLRELPESILPEHLRIQSTEILSNGRFGEKEKIKEI-QTLLSNLSRP DDB0229973_Ddis ------------------------------------------------------------ DDB0230010_Ddis ------------------------------------------------------------ IfkA_Ddis -----------------------------------------KKSKIETLVQTSLSKL--- CC1G_01579_Ccin ------------------------------------------------------------ AqueK223_Aque -------------------------------------------------SSSSIG----- STE-Un_a_Smoe ------------------------------------------------------------ STE-Un_b_Smoe ------------------------------------------------------------ NIK_Hsap -------------------EFHRVKVGDIATGISS--QIPAAAFSLVTKDGQPVRYDMEV NIK_Mmus -------------------EFHRVKVGDIATGISS--QIPATAFSLVTKDGQPVCYDMEV COT_Mmus ------------------------------------------------------------ COT_Hsap ------------------------------------------------------------ DDB0229972_Ddis HYNVLKHMLFFAKLVVDRSEYNKMVIANVTTCFSPTLRIPPGLFNFLIN-----TY---- DDB0229973_Ddis ------------------------------------------------------------ DDB0230010_Ddis -------------------------------------------------------K---- IfkA_Ddis -----------------------------FRGFI--QSKSSTIRVIVTDLAYSVIRDLQI CC1G_01579_Ccin ------------------------------------------------------------ AqueK223_Aque --------------------------------------------------------GLTS STE-Un_a_Smoe ------------------------------------------------------------ STE-Un_b_Smoe -----------------------------------------------------------A NIK_Hsap PDSGIDLQCTLAP-----------------DGSFAWSWRV------------KHGQLENR NIK_Mmus PDSGIDLQCTLAP-----------------DGSFAWTWRV------------KHGQLENR COT_Mmus ------------------------------LGALAGYFNI-----------VRGPPTLEY COT_Hsap ------------------------------LGALAGYFNL-----------VRGPPTLEY DDB0229972_Ddis --------------------------------------DL------------SFPKFNLS DDB0229973_Ddis ----------------------------------------------------LKNTGMMT DDB0230010_Ddis ---------------------------------------------------NLLLDNFVA IfkA_Ddis SESHDNI--------SKFQRVSKEKLLQ-LKNQ-IFKWKVYPFIVIHSIKDDKSVIFNSV CC1G_01579_Ccin ------------------------------ENE-MEAWLA------------RLWDWPQA AqueK223_Aque SSAPP----------NFNG----------------GCWED-----------DIEKDGPNN STE-Un_a_Smoe ---------------------------------------------------------KLV STE-Un_b_Smoe PDTDISMSCVVDAARDKPAESLEPESPKVAKKS-LVSWLC--------------CGCWNR NIK_Hsap P NIK_Mmus P COT_Mmus G COT_Hsap G DDB0229972_Ddis V DDB0229973_Ddis E DDB0230010_Ddis F IfkA_Ddis V CC1G_01579_Ccin S AqueK223_Aque S STE-Un_a_Smoe E STE-Un_b_Smoe P