CLUSTAL W (1.83) multiple sequence alignment TIF1g_Hsap MAENKGGGEAES------------------GGGGSGSAPVTAGA---------------- TIF1b_Hsap MAASAAAA---------------------------------------------------- TIF1a_Hsap MEVAVEKA---------------------------------------------------- TIF1_Spur MSSSRRSMYSISVLALVFVVGPGVIKLPGAGAGMCGCPPLWTGFNDNCYRFFVSGNLSWF bon_Dmel MDMDLEQLKN-------------------------------------------------- TIF1a_Mmus MEVAVEKA---------------------------------------------------- TIF1b_Mmus MAASAAAT---------------------------------------------------- TIF1g_Mmus MAENKGGGEAES------------------GGGGSGSAPVTAGA---------------- TIF1D_Hsap MA---------------------------------------------------------- TIF1D_Mmus MA---------------------------------------------------------- * TIF1g_Hsap ---------AGPAAQEAEP----PLTAVLVEEEEEEGGRA-------------------- TIF1b_Hsap ------------------------------------------------------------ TIF1a_Hsap ------------------------------------------------------------ TIF1_Spur DAELACRTFSTPCGEESSSSSMGHLVSIHSQEEMD-FITAMYDSLRSKRPTIDTRTWIGL bon_Dmel -------------------D-FLPLIAGIKQEQLD-A----------------------- TIF1a_Mmus ------------------------------------------------------------ TIF1b_Mmus ------------------------------------------------------------ TIF1g_Mmus ---------AGPTAQEAEP----PLAAVLVEEEEEEGGRA-------------------- TIF1D_Hsap ------------------------------------------------------------ TIF1D_Mmus ------------------------------------------------------------ TIF1g_Hsap ---GAEGGAAGPDDGGVAAASSGS-AQAAS----------------------SPAASVGT TIF1b_Hsap ------------------SA---A-AASAA----------------------SGSPGPGE TIF1a_Hsap ------------------VAAAAA-ASAAA----------------------SGGP---- TIF1_Spur HDRTAEQSAEWTDSSDFDYASWAPSQPNDQNGASDCVFFSRNTLYKWNDIPCTPGSRVES bon_Dmel ----------VP----TDALPQMS-TPNTA----------------------SGAPTTSS TIF1a_Mmus ------------------AAAAAP-A---------------------------GGPA--- TIF1b_Mmus -----------------AAASAAT-AASAA----------------------SGSPGSGE TIF1g_Mmus ---GAEGGAAGPDDGGVAAASSSS-APAAS----------------------VPAASVGS TIF1D_Hsap ------------------------------------------------------------ TIF1D_Mmus ------------------------------------------------------------ TIF1g_Hsap GVAGGAVSTPAP--------------APASAPAPGPSAGPPPGPPASLLDTCAVCQQSLQ TIF1b_Hsap GSAGGEKRSTAP----SAA------ASASASAAASSPAG-GGAEALELLEHCGVCRERLR TIF1a_Hsap --------SAAP----SGE------NEAESRQGPDSERG-GEAARLNLLDTCAVCHQNIQ TIF1_Spur ----------------FVS------DSITSETMEASTSG-QGTSNIHLDLKCKVCEREFS bon_Dmel LS------SSSL----SLS------NPC-DSAEKRSESN-SSASAKFTLFKCVYCAQLLG TIF1a_Mmus --------AAAP----SGE------NEAESRQGPDSESG-GEASRLNLLDTCAVCHQNIQ TIF1b_Mmus GSAGGEKR---P----AAS------SAAAASAAASSPAG-GGGEAQELLEHCGVCRERLR TIF1g_Mmus AVPGGAASTPAPAAAPAPAPAPAPAPAPAPAPAPGSSSGPPLGPPASLLDTCAVCQQSLQ TIF1D_Hsap ------------------------------------------------------------ TIF1D_Mmus ------------------------------------------------------------ TIF1g_Hsap SRREAEPKLLPCLHSFCLRCLPEPERQLSVPI----------------------PGGSNG TIF1b_Hsap P--EREPRLLPCLHSACSACLGPAAPAAA------------------------NSSGDGG TIF1a_Hsap SR---APKLLPCLHSFCQRCLPAPQRYLMLPAPMLGSAETPPP--VPA--PGSPVSGSSP TIF1_Spur A--DVQPRMLPCLHTVCAQCLANVTNNTAL------------------------ASGQQG bon_Dmel S--NDRPKLLECLHVACAQCVSTKFSELDRSL---------------------------- TIF1a_Mmus SR---VPKLLPCLHSFCQRCLPAPQRYLMLTAPALGSAETPPPAPAPAPAPGSPAGGPSP TIF1b_Mmus P--ERDPRLLPCLHSACSACLGPATPAAA------------------------NNSGDGG TIF1g_Mmus SRREAEPKLLPCLHSFCLRCLPEPERQLSVPI----------------------PGGSNG TIF1D_Hsap ------------------------------------------------------------ TIF1D_Mmus ------------------------------------------------------------ TIF1g_Hsap DIQQ--VGVIRCPVCRQECRQI-DLVDNYFVKDTSEAPSS---------------SDEKS TIF1b_Hsap AAGD--GTVVDCPVCKQQCFSK-DIVENYFMRDSGSKAAT---------------DAQDA TIF1a_Hsap FATQ--VGVIRCPVCSQECAER-HIIDNFFVKDTTEVPSS---------------TVEKS TIF1_Spur ILAGSGVVIAKCPICKDDIRSLDDIVEDTWTVPMATA--H---------------SMSGG bon_Dmel ------PPLIHCPVCDNASQQE-FIVDNQFLIEQCTAGDSGDGVGLLGLTGEGQKSSAAA TIF1a_Mmus FATQ--VGVIRCPVCSQECAER-HIIDNFFVKDTTEVPSS---------------TVEKS TIF1b_Mmus SAGD--GAMVDCPVCKQQCYSK-DIVENYFMRDSGSKASS---------------DSQDA TIF1g_Mmus DVQQ--VGVIRCPVCRQECRQI-DLVDNYFVKDTSEAPSS---------------SDEKS TIF1D_Hsap ------------------------------------------------------------ TIF1D_Mmus ------------------------------------------------------------ TIF1g_Hsap EQVCTSCEDNASAVGFCVECGEWLCKTCIEAHQRVKFTKDHLIRKKEDVS-ES-VGASG- TIF1b_Hsap NQCCTSCEDNAPATSYCVECSEPLCETCVEAHQRVKYTKDHTVRSTGP----A-KSRDG- TIF1a_Hsap NQVCTSCEDNAEANGFCVECVEWLCKTCIRAHQRVKFTKDHTVRQKEEVSPEA-VGVTS- TIF1_Spur EMLCHNCDANAPATNFCVDCPGGLCDPCVLLHGKVRFLRDHVIQPRSEEN----TVSHI- bon_Dmel SIQCSSCSDGAVATSWCVDCSEYICDSCVQAHQRLKITKDHTIKPKDEANNEQLAGAAGV TIF1a_Mmus NQVCTSCEDNAEANGFCVECVEWLCKTCIRAHQRVKFTKDHTVRQKEEVSPEA-VGVTS- TIF1b_Mmus NQCCTSCEDNAPATSYCVECSEPLCETCVEAHQRVKYTKDHTVRSTGP----A-KTRDG- TIF1g_Mmus EQVCTSCEDNASAVGFCVECGEWLCKTCIEAHQRVKFTKDHLIRKKEDVS-ES-VGTSG- TIF1D_Hsap -RNCSECKEKRAAHILCTYCNRWLCSSCTEEHRHSPVPGGPFFPRAQKGSPGV-NGGPG- TIF1D_Mmus -RNCSECKEKRAAHILCTYCNRWLCSSCTEEHRHVPAPGGPLFARAQKGSSGV-NGGSG- * .*. * *. * :*..* * : . . TIF1g_Hsap QRPVFCPVHKQEQLKLFCETCDRLTCRDCQLLEHKEHRYQFLEEAFQNQKGAIENLLAKL TIF1b_Hsap ERTVYCNVHKHEPLVLFCESCDTLTCRDCQLNAHKDHQYQFLEDAVRNQRKLLASLVKRL TIF1a_Hsap QRPVFCPFHKKEQLKLYCETCDKLTCRDCQLLEHKEHRYQFIEEAFQNQKVIIDTLITKL TIF1_Spur VQPPFCTIHPKERLQLYCEKCVRLTCRDCQLVSHKDHSYQFLTEAAASQRLTMRRFIQEL bon_Dmel DKLHMCQLHPQEKLSLFCETCDKLTCRDCQLSDHRDHKYKFAHEIATESRQALSTLVSEI TIF1a_Mmus QRPVFCPFHKKEQLKLYCETCDKLTCRDCQLLEHKEHRYQFIEEAFQNQKVIIDTLITKL TIF1b_Mmus ERTVYCNVHKHEPLVLFCESCDTLTCRDCQLNAHKDHQYQFLEDAVRNQRKLLASLVKRL TIF1g_Mmus QRPVFCPVHKQEQLKLFCETCDRLTCRDCQLLEHKEHRYQFLEEAFQNQKGAIENLLAKL TIF1D_Hsap DFTLYCPLHTQEVLKLFCETCDMLTCHSCLVVEHKEHRCRHVEEVLQNQRMLLEGVTTQV TIF1D_Mmus DFALYCPLHTQEVLKLFCETCDVLTCHSCLMVEHKEHRCRHVEEVLQNQRMLLESVTSQV * .* :* * *:**.* ***:.* : *::* :. : ..: : . .: TIF1g_Hsap LEKKNYVHFAATQVQNRIKEVNETNKRVEQEIKVAIFTLINEINKKGKSLLQQLENVTKE TIF1b_Hsap GDKHATLQKSTKEVRSSIRQVSDVQKRVQVDVKMAILQIMKELNKRGRVLVNDAQKVTEG TIF1a_Hsap MEKTKYIKFTGNQIQNRIIEVNQNQKQVEQDIKVAIFTLMVEINKKGKALLHQLESLAKD TIF1_Spur QEKRKNAKVMKNNIQIIYKKMKDQESIILGRIDELFNGIRSAIDGQATALKTKIQSSTEN bon_Dmel NYKRFLLSSATKVIDDRQQLIHDKKKDLIKEITAMAVKITNTVNTRGKQLIMRLNEVCDS TIF1a_Mmus MEKTKYIKYTGNQIQNRIIEINQNQKQVEQDIKVAIFTLMVEINKKGKALLHQLESLAKD TIF1b_Mmus GDKHATLQKNTKEVRSSIRQVSDVQKRVQVDVKMAILQIMKELNKRGRVLVNDAQKVTEG TIF1g_Mmus LEKKNYVHFAATQVQNRIKEVNETNKRVEQEIKVAIFTLINEINKKGKSLLQQLENVTKE TIF1D_Hsap AHKKSSLQTSAKQIEDRIFEVKHQHRKVENQIKMAKMVLMNELNKQANGLIEELEGITNE TIF1D_Mmus AHKKSSLQTSAKQIEDRIFEVKHQHRKVENQIKMAKMVLMNELNKQANGLIEELEGITNE * . : : . . : : : :: :. * : . TIF1g_Hsap RQMKLLQQQNDITGLSRQVKHVMNFTNWAIASGSSTALLYSKRLITFQLRHILKARCDP- TIF1b_Hsap QQERLERQHWTMTKIQKHQEHILRFASWALESDNNTALLLSKKLIYFQLHRALKMIVDP- TIF1a_Hsap HRMKLMQQQQEVAGLSKQLEHVMHFSKWAVSSGSSTALLYSKRLITYRLRHLLRARCDA- TIF1_Spur KCRTLKQQLIEVGTVDSALSQCYRVIHNIMTSENDVAALQQNRLVKRRVDLVLRTLLTR- bon_Dmel KLKVLVEKKETLQLLSDNTDHCIDFMQNALEKGSDFAILSSKKSLVRHLQKLKCQRADIP TIF1a_Mmus HRMKLMQQQQEVAGLSKQLEHVMHFSKWAVSSGSSTALLYSKRLITYRLRHLLRARCDA- TIF1b_Mmus QQERLERQHWTMTKIQKHQEHILRFASWALESDNNTALLLSKKLIYFQLHRALKMIVDP- TIF1g_Mmus RQMKLLQQQNDITGLSRQVKHVMNFTNWAIASGSSTALLYSKRLITFQLRHILKARCDP- TIF1D_Hsap RKRKLEQQLQSIMVLNRQFEHVQNFINWAVCSKTSVPFLFSKELIVFQMQRLLETSCNT- TIF1D_Mmus RKRKLEQQLQSIMVLNRQFEHVQNFINWAVCSKSSVPFLFSKELIVFQMQRLLETRCNT- : * .: : :. .: . : . .. . * .:. : :: TIF1g_Hsap VPAANGAIRFHCDP-TFWAKNVVNLGNLVI-ESKPA-------P---------------- TIF1b_Hsap VE-PHGEMKFQWDL-NAWTKSAEAFGKIVA-ERPGT-------N---------------- TIF1a_Hsap SPVTNNTIQFHCDP-SFWAQNIINLGSLVI-EDKESQPQ---MP---------------- TIF1_Spur QPVTELALQFKQTN-VPTRDAFKSIGSIEGMESKVL-FG---PP--------------GQ bon_Dmel NPEIPVRIQVQLNQVSDLQKVISQLGIIIV-DGKPYP-P---TP---------------- TIF1a_Mmus SPVTNTTIQFHCDP-SFWAQNIINLGSLVI-EDKESQPQ---MP---------------- TIF1b_Mmus VE-PHGEMKFQWDL-NAWTKSAEAFGKIVA-ERPGT-------N---------------- TIF1g_Mmus VPAANGAIRFHCDP-TFWAKNVVNLGNLVI-ESKPA-------P---------------- TIF1D_Hsap DPGSPWSIRFTWEP-NFWTKQLASLGCITT-EGGQMSRAD--APAYGGLQGSSPFYQSHQ TIF1D_Mmus DPGSPWSIRFTWEP-NFWTKQLASLGCITT-EGGQLTRADAAAASYGSLQGQPSFYQSHQ ::. . :* : : TIF1g_Hsap ---------------GYTPNV----------------VVGQVPPG---TNHI---SKTPG TIF1b_Hsap ---------------ST------------------------------------------- TIF1a_Hsap ---------------KQNPVV----------------EQNSQPPSGLSSNQL---SKFPT TIF1_Spur QQI------------RQNQGF----------------PHNMQPGLALNRAAL---VQQQA bon_Dmel ---------------SPNGT-----------------PQPQHPP------------RQPP TIF1a_Mmus ---------------KQNPVV----------------EQSSQPPGGLPSNQL---SKFPT TIF1b_Mmus ---------------ST------------------------------------------- TIF1g_Mmus ---------------GYTPNV----------------VVGQVPPG---TNHI---SKTPG TIF1D_Hsap SPVAQQEALSHPSHKFQSPAVCSSSVCCSHCSPVSPSLKGQVPPP---SIHPAHSFRQPP TIF1D_Mmus APMAQQEALSHPSHKFQSPALCSSSVCCSHCSPVSPSLKGQVPPP---SIHPAHSFRQPS TIF1g_Hsap QINLA------------------------------------------------------- TIF1b_Hsap ------------------------------------------------------------ TIF1a_Hsap QISLA------------------------------------------------------- TIF1_Spur QLQAQ------------------------------------------------------- bon_Dmel SPNMA--------PPLRPGLPPGMPAGLSPNGPPVNFGPQNGP----------------- TIF1a_Mmus QISLA------------------------------------------------------- TIF1b_Mmus ------------------------------------------------------------ TIF1g_Mmus QINLA------------------------------------------------------- TIF1D_Hsap EMVPQQLGSLQCSAL----LPREKELACSPHPPKLLQPWLETQPPVEQESTSQRLGQQLT TIF1D_Mmus EMVPHQLGSLQCSTL----LPREKELACSPHPPKLMQPWLEPQPPAEQESTSQRPGPQLV TIF1g_Hsap ---------------------------QLRLQHMQQQVYAQKHQQLQQMRMQQPP----- TIF1b_Hsap -----------------------------------------------------GP----- TIF1a_Hsap ---------------------------QLRLQHMQQQVMAQRQQ------VQRRP----- TIF1_Spur ---------------------------QQAQQQAQQQAQQQAHMQ--QRQLQQQQGINHA bon_Dmel ---------------------------PLYSNAAQQQ--------FNNL-SMSR------ TIF1a_Mmus ---------------------------QLRLQHIQQQVMAQRQQ------VQRRP----- TIF1b_Mmus -----------------------------------------------------GP----- TIF1g_Mmus ---------------------------QLRLQHMQQQVYAQKHQQLQQMRLQQPP----- TIF1D_Hsap SQPVCIVPPQDVQQGAHAQPTLQTPSIQVQFGHHQKLKLSHFQQQPQ-QQLPPPP----- TIF1D_Mmus SQPVCIVPPQDVQPGAHAQPTIQTPSIQVQLGHHQKLKLSHFQQQPQ-QQ-PPPP----- TIF1g_Hsap -----------------------AP---------VPTT-TTTTQQHPRQAAPQ------- TIF1b_Hsap -----------------------AP---------M--A-PP-RAPGPLSKQGS------- TIF1a_Hsap -----------------------AP---------VGLP-NP-RMQGPIQQPSI------- TIF1_Spur LFSQRSIGEQLARVNRPTVCAPTIH---------IPRGLQAQQQQQQQQVRPA------- bon_Dmel ----------------SF------PGDGSGKVRFGG--MPPVGMQR-HGQPHV------- TIF1a_Mmus -----------------------AP---------VGLP-NP-RMQGPIQQPSI------- TIF1b_Mmus -----------------------GP---------M--A-PP-RAPGPLSKQGS------- TIF1g_Mmus -----------------------AP---------IPTT-TATTQQHPRQAAPQ------- TIF1D_Hsap -----------------------PP---------LPHP-PP-PLPPPPQQPHPPLPPSQH TIF1D_Mmus ----------------------------------------P-PPPPPPQHAPPPLPPSQH . TIF1g_Hsap ---MLQQQPPRLISVQTMQ----------------------RGNMNCGAFQAHQMRLAQ- TIF1b_Hsap ---GSSQPMEVQE----------------------------------------------- TIF1a_Hsap ---SHQQPPPRLINFQN------------------------------------------- TIF1_Spur ---MQTNILPVLTNPQNTM----------------------GIRPS----TSTQLT---- bon_Dmel ---SSSTHPQ---NMDISL----------------------RGLLNNQAAQSPNAHMAF- TIF1a_Mmus ---SHQHPPPRLINFQN------------------------------------------- TIF1b_Mmus ---GSSQPMEVQE----------------------------------------------- TIF1g_Mmus ---MLQQQPPRLISVQTMQ----------------------RGNMNCGAFQAHQMRLAQ- TIF1D_Hsap LASSQHESPPGPACSQNMDIMHHKFELEEMQKDLELLLQAQQPSLQLSQTKSPQ-HLQQT TIF1D_Mmus LASSQHESPPGPACSQNVDIMHHKFELEEMQKDLELLLQAQQPSLQLSQTKSPQ-HLQQT TIF1g_Hsap NAA-RIPGIPRHSG-PQYSMMQP-HLQRQ---HSNPGHAG----PFP------------- TIF1b_Hsap -------GYGFGSGDDPYSSAEP-HVSGVKRSRSGEGEVSGLMRKVP------------- TIF1a_Hsap -----------HSPKPNGPVLPP-HPQQL---RYPPNQNI----PRQA-IK-PNPLQ--- TIF1_Spur ----------HGLPTSMQPVGPP-N------------VTV------TSAMT-FGDLTTAQ bon_Dmel NGPPSYPGGPQGAPAPAHQPMGP-QM-RP---HFMPGQQG----FSQGGGPGGGPRD--- TIF1a_Mmus -----------HSPKPNGPVLPP-YPQQL---RYSPSQNV----PRQTTIK-PNPLQ--- TIF1b_Mmus -------GYGFGS-DDPYSSAEP-HVSGMKRSRSGEGEVSGLLRKVP------------- TIF1g_Mmus NAA-RIPGIPRHSA-PQYSMMQP-HLQRQ---HSNPGHAG----PFP------------- TIF1D_Hsap IVG-QINYIVRQPA-PVQSQSQEETLQAT---DEPPASQG----SKP------------- TIF1D_Mmus IVG-QINYIVRQPA-PVQSQSQEETLQVT---EEPPAPEG----PKP------------- TIF1g_Hsap ----------------------------VVSVHN-TTINP-------------------- TIF1b_Hsap ----------------------------RVSLER-LDLDL-------------------- TIF1a_Hsap -MAFLAQQAIKQWQISSGQGTP------STTNS--TSSTP-------------------- TIF1_Spur RKQLMAQ--VKQNQALNARSPPSVSPSAATAVRNTNSASP-------------------- bon_Dmel -ANFMNSNARFQSQYQ------RMAN--------HAQQAA-------------------- TIF1a_Mmus -MAFLAQQAIKQWQISSVQAPP------TTASS--SSSTP-------------------- TIF1b_Mmus ----------------------------RVSLER-LDLDL-------------------- TIF1g_Mmus ----------------------------VVSAHN--PINP-------------------- TIF1D_Hsap ----------------------------ALPLDK-NTAAALPQASGEETPLSVPPVDSTI TIF1D_Mmus ----------------------------ALPVDK-NTAAPLPQTSGEETPHSVPPVDGTS TIF1g_Hsap --TSPTTA--------TMANANR-----------GPTSPSVTAIELIPSVT---NPENL- TIF1b_Hsap --TADSQP--------PVFK---------------------------------------- TIF1a_Hsap --SSPTIT--------SAAGY-D-----------GKA-FGSPMIDLSSPVG---GSYNL- TIF1_Spur --SSMGAT--------TVRNTNS----------ASPSSMIAPANDTSGPRILSVKSERRP bon_Dmel --AAAAMA--------GAAGG-G-----------GGQIPSPGALQRPQMMS---NPM--- TIF1a_Mmus --SSPTIT--------SAAGY-D-----------GKA-FSSPMIDLSAPVG---GSYNL- TIF1b_Mmus --TSDSQP--------PVFK---------------------------------------- TIF1g_Mmus --TSPTTA--------TMANANR-----------GPTSPSVTAIELIPSVT---NPENL- TIF1D_Hsap QHSSPNVVRKHSTSLSIMGFSNTLEMELSSTRLERPLEPQIQSVSNL-TAG---APQAV- TIF1D_Mmus QHSSPNVVRKHATSVSIMGFSNTVEMELSSTRLARTIEPQIHRVSSL-TAA---PTHTI- :: TIF1g_Hsap ---------------------------------------------------------PSL TIF1b_Hsap ------------------------------------------------------------ TIF1a_Hsap ---------------------------------------------------------PSL TIF1_Spur SKSDSERSSCRFENQSSGSTMIGNGLQDTQPSSSGLEMQQGSDKTSPVQSDVQMGGTPER bon_Dmel ---------------------Q--------------------NV-------------SAM TIF1a_Mmus ---------------------------------------------------------PSL TIF1b_Mmus ------------------------------------------------------------ TIF1g_Mmus ---------------------------------------------------------PSL TIF1D_Hsap ---------------------------------------------------------PSL TIF1D_Mmus ---------------------------------------------------------PSL TIF1g_Hsap PD-------------IPPIQLEDAGSSSLD-NLL------------------------SR TIF1b_Hsap ---------------------VFPGSTTEDYNLI-------------------------- TIF1a_Hsap PD-------------I---DC--SSTIMLD-NIV------------------------RK TIF1_Spur PDQQMGR--------TPPLTSSATSPDALE-DILGIDLPVQVNASDIIGDIMDEVALETR bon_Dmel QNSLGFHGSQAGFNTGPPQTSPQLGGGGMH-SLAKWHIPQSAQQSNM------------- TIF1a_Mmus PD-------------I---DC--SSTIMLD-NIA------------------------RK TIF1b_Mmus ---------------------VFPGSTTEDYNLI-------------------------- TIF1g_Mmus PD-------------IPPIQLEDAGSSSLD-NLL------------------------SR TIF1D_Hsap LS-------------APPKMV--SSLTSVQ-NQA------------------------MP TIF1D_Mmus LS-------------GPPQTV--SSLMSVS-NHA------------------------MP . . TIF1g_Hsap Y--ISGSHLPPQPTSTM-N----------------------PSPGPSALSPGSSG---LS TIF1b_Hsap -------------------V---------------------IERGAAAAATGQPG---TA TIF1a_Hsap D--TNIDHGQPRPPSNR-TV---------------------QSPNSSVPSPGLAGPVTMT TIF1_Spur DSGESADNSDPAPTRES-TSE--------------------ETSGSAAEASGDGA-GSVA bon_Dmel ----CSQQGPLLPFANG-R-Q--------------------TSENFKI---SLKSPNTLK TIF1a_Mmus D--TGVDHAQPRPPSNR-TV---------------------QSPNSSVPSPGLAGPVTMT TIF1b_Mmus -------------------V---------------------IERGAAAAAAGQAG---TV TIF1g_Mmus Y--ISGSHLPPQPTSTM-N----------------------PSPGPSALSPGSSG---LS TIF1D_Hsap S--LTTSHLQTVPSLVHSTFQSMPNLISDSPQAMASLASDHPQAGPSLMSGHTQAVPS-- TIF1D_Mmus S--LTASHLQPVPNLVRGTFQSTSNLRGDSSQAITGLASNHSQAGPSLMSGHTQAAPS-- . . TIF1g_Hsap NS---------------------------------HTPVR--PPS--------------- TIF1b_Hsap PA---------------------------------GTPGA--PPL--------------- TIF1a_Hsap SV---------------------------------HPPIR--SPS--------------- TIF1_Spur EASGSGAGSVAGASGSGAGSVAEASGDGTESVAEASGDGA--GPSGSGAGSVSEGSGSGA bon_Dmel NS---------------------------------TPPSL-------------------- TIF1a_Mmus SV---------------------------------HPPIR--SPS--------------- TIF1b_Mmus PP---------------------------------GAPGA--PPL--------------- TIF1g_Mmus NS---------------------------------HTPVR--PPS--------------- TIF1D_Hsap LA---------------------------------TCPLQSIPPV--------------- TIF1D_Mmus LA---------------------------------TCPLQGMPPV--------------- TIF1g_Hsap ----TSST--GSRGS-CGSSGRTAEKT--------------------------------- TIF1b_Hsap ----AG------------------------------------------------------ TIF1a_Hsap ----ASSV--GSRGS-SGSSSKPAGAD--------------------------------- TIF1_Spur IAPGEGSS--GDPGV-VEASGSGAARA-------------------VGSE---------- bon_Dmel -G--GGGA--GHQGHGNGSSSAQLNAA--------------------------------- TIF1a_Mmus ----ASSV--GSRGS-SGSSSKPAGAD--------------------------------- TIF1b_Mmus ----PG------------------------------------------------------ TIF1g_Mmus ----TSST--GSRGS-CGSSGRTAEKS--------------------------------- TIF1D_Hsap ----SDMQ--PETGS-SSSSGRTSGSLCPRDGADPSLENALCKVRKMESEDSTRFTDLLG TIF1D_Mmus ----SDVHVEPRSVS-SPGSGPAAESLGTRDGAESSLGNALC---KMESEDCTRFSDSVG . TIF1g_Hsap ------------------------------------------------------------ TIF1b_Hsap ------------------------------------------------------------ TIF1a_Hsap ------------------------------------------------------------ TIF1_Spur ------------------------------------------------------------ bon_Dmel ------------------------------------------------------------ TIF1a_Mmus ------------------------------------------------------------ TIF1b_Mmus ------------------------------------------------------------ TIF1g_Mmus ------------------------------------------------------------ TIF1D_Hsap QGPIVPGLDAPKDLAIPSELEEPINLSVKKPPLAPVVSTSTALQQYQNPKECENFEQGAL TIF1D_Mmus QGPTASSLDGPKDLAIPSELEEPINLSVKKPFLAPVINTSTALQQYRNPKEYENFEQGAL TIF1g_Hsap ---------------SLS---F-KSDQVKV-------KQEPG----TEDEICSFSG-GVK TIF1b_Hsap -------------------------------------------------------MAIVK TIF1a_Hsap --------------STHKVPVV-MLEPIRI-------KQENS----GPPENYDFPVVIVK TIF1_Spur --------------DVEKHGKE-KLSRIRVFLNEMDDSMHEA----TKESIAAFWKGDVS bon_Dmel --------------ALGLGPAVSILSNVTS-------TNPKTPSPSTHENTKDFTEPIDK TIF1a_Mmus --------------STHKVPVV-MLEPIRI-------KQENS----GPPENYDFPVVIVK TIF1b_Mmus -------------------------------------------------------MAIVK TIF1g_Mmus ---------------AHS---F-KSDQVKV-------KQEPG----TEEEICSFSG-AVK TIF1D_Hsap ELDAKENQSIRAFNSEHKIPYV-RLERLKI-------CAASS----GE-----MPVFKL- TIF1D_Mmus ELDTKENSDIRAISSEPKIPYV-RLERLKI-------CAASS----GE-----MPVFKL- TIF1g_Hsap -QEKTEDGRRSAC-MLS--------------SP--------ESSLTPPLSTNL------- TIF1b_Hsap -EEETEAAIGAPPTATE--------------GP--------E---TKPVLMAL------- TIF1a_Hsap -QESDEESRPQN---AN--------------YP--------RSILTS-----L------- TIF1_Spur WEERDDQGKPRRQVIVGSLYRMTSKKYSREGWPSKLHIKMMHSGMLKPLIDLMRDHQLFF bon_Dmel --VRDD-------------------------------------SINDLIATI-------- TIF1a_Mmus -QESDEESRPQN---TN--------------YP--------RSILTS-----L------- TIF1b_Mmus -EEETEAAIGAPPAAPE--------------GP--------E---TKPVLMPL------- TIF1g_Mmus -QEKTEDGRRSAC-MLS--------------SP--------ESSLTPPLSTNL------- TIF1D_Hsap --------KPQK---ND--------------QD--------GSFLL-------------- TIF1D_Mmus --------KPQK---NS--------------QD--------GNFLL-------------- TIF1g_Hsap ------------------------------------------------------------ TIF1b_Hsap ----AEGPG--------------------AEGPR-------------------------- TIF1a_Hsap ------------------------------------------------------------ TIF1_Spur LKCDQECKELYRKLVAIFKNKDVFGAIRLYSKPEIILLLFYSHKHQKFFIVCPQQREQFS bon_Dmel ------------------------------------------------------------ TIF1a_Mmus ------------------------------------------------------------ TIF1b_Mmus ----TEGPG--------------------AEGPR-------------------------- TIF1g_Mmus ------------------------------------------------------------ TIF1D_Hsap ------------------------------------------------------------ TIF1D_Mmus ------------------------------------------------------------ TIF1g_Hsap ---------HLESELDALASLENHVK-----IEPADMNESCKQSGLS------------- TIF1b_Hsap ---------LASPSGS-TSSGLEVVA-----PEGT------------------------- TIF1a_Hsap ---------LLNSSQS-STSEETVLR-----SDAP--DSTGDQPGLHQD----------- TIF1_Spur IGFVKTMEKYFKVQRK-GASDK--PN-----PESSTVSTADGDPGTSET----------- bon_Dmel -------------AKL-DSNGVQVLPEGRTKTTSPQVHSSTDL----------------- TIF1a_Mmus ---------LLNSSQS-SASEETVLR-----SDAP--DSTGDQPGLHQE----------- TIF1b_Mmus ---------LASPSGS-TSSGLEVVA-----PEVT------------------------- TIF1g_Mmus ---------HLESELDTLTGLENHVK-----TEPTDISESCKQSGLS------------- TIF1D_Hsap -----II--ECGT-E-SSSMSIKVSQ--------DRLSEATQAPGLEGRKVTVTSLAGQR TIF1D_Mmus -----VI--ECGT-E-SSSMSIKVSQ--------NSLPDASQGPGLGGRKVTVTSLTGQQ : TIF1g_Hsap -SLVNGKSPI-RSLMHRSA------------------------RIGGDGNNKDDDPNEDW TIF1b_Hsap -----------------SA------------------------PGGGPG-T--LDDSATI TIF1a_Hsap -NSSNGKSEW-LDPSQKSP------------------------LHVGE-TRKEDDPNEDW TIF1_Spur -APTSGEKRP-IDEDVPSTSQAGTSRNGEESIEPIPTWKQGYKLRNGMQCSRSDDPNDDW bon_Dmel --------------SN--TQ-----------------------EV-NNKNEQKDDPNEDW TIF1a_Mmus -NSSNGKSEW-SDASQKSP------------------------VHVGE-TRKEDDPNEDW TIF1b_Mmus -----------------SA------------------------PVSGPG-I--LDDSATI TIF1g_Mmus -NLVNGKSPI-RNLMHRSA------------------------RIGGDGNSKDDDPNEDW TIF1D_Hsap PPEVEGTSPEEHRLIPR--------------------------TPGAKKGPPAPIENEDF TIF1D_Mmus PQEVESTSE-EHRLIPR--------------------------APGAKKNTPAPIENEDF . TIF1g_Hsap CAVCQNGGDLLCCEKCPKVFHLTCHVPTLLSFPS--GDWICTFCRDIGKPEVEYDCDNLQ TIF1b_Hsap CRVCQKPGDLVMCNQCEFCFHLDCHLPALQDVPG--EEWSCSLCHVLPDLKEEDGSLSLD TIF1a_Hsap CAVCQNGGELLCCEKCPKVFHLSCHVPTLTNFPS--GEWICTFCRDLSKPEVEYDCDAPS TIF1_Spur CAVCNNGGNLVCCDRCPRVYHHECHVPLISEVPED-DDFDCTLCFDVVADEEEN-V---- bon_Dmel CAVCLDGGELMCCDKCPKVFHQNCHIPAISSLPDESESWQCLLCVNIKELTKTEGS---- TIF1a_Mmus CAVCQNGGELLCCEKCPKVFHLTCHVPTLTNFPS--GEWICTFCRDLSKPEVDYDCDVPS TIF1b_Mmus CRVCQKPGDLVMCNQCEFCFHLDCHLPALQDVPG--EEWSCSLCHVLPDLKEEDGSLSLD TIF1g_Mmus CAVCQNGGDLLCCEKCPKVFHLTCHVPTLLSFPS--GDWICTFCRDIGKPEVEYDCDNMQ TIF1D_Hsap CAVCLNGGELLCCDRCPKVFHLSCHVPALLSFPG--GEWVCTLCRSLTQPEMEYDCENAC TIF1D_Mmus CAVCINGGELLCCDRCPKVYHLSCHVPALLSFPG--GEWVCTLCRSLTQPEMEYDCENAR * ** . *:*: *::* :* **:* : ..* .: * :* : TIF1g_Hsap HSKK-GKTAQ---GLSPVDQRKCERLLLYLYCH-ELSIEFQEPVPASIPNYYKIIKKPMD TIF1b_Hsap GADS-TGVV---AKLSPANQRKCERVLLALFCH-EPCRPLHQLATDSTF-SLDQPGGTLD TIF1a_Hsap HNSE-KKKTEGLVKLTPIDKRKCERLLLFLYCH-EMSLAFQDPVPLTVPDYYKIIKNPMD TIF1_Spur NNEN-AEKLE---GFTAREFKLCQRLLLEMYCL-EDSQPFLEPVGPEVTGYLEIIPIPMD bon_Dmel ---E-KSSSG---ELSALELRILQRICLELYCQYEQSLNFREPESPANTSYYEIVSSPMS TIF1a_Mmus HHSE-KRKSEGLTKLTPIDKRKCERLLLFLYCH-EMSLAFQDPVPLTVPDYYKIIKNPMD TIF1b_Mmus GADS-TGVV---AKLSPANQRKCERVLLALFCH-EPCRPLHQLATDSTF-SMEQPGGTLD TIF1g_Mmus HSKK-GKTAQ---GLSPVDQRKCERLLLYLYCH-ELSIEFQEPVPVSIPNYYKIIKKPMD TIF1D_Hsap YNQPGMRASP---GLSMYDQKKCEKLVLSLCCN-NLSLPFHEPVSPLARHYYQIIKRPMD TIF1D_Mmus YGHPGVRVLP---GLSMYDQKKCEKLVLSLCCN-SLSLPFHEPVSPLARHYYQIIKRPMD :: : : ::: * : * . . : : . .:. TIF1g_Hsap LSTVKKKLQKKHSQHYQIPDDFVADVRLIFKNCERFNEMMKVVQVYADTQEINLKADSEV TIF1b_Hsap LTLIRARLQEKLSPPYSSPQEFAQDVGRMFKQFNKLTED-----------------KADV TIF1a_Hsap LSTIKKRLQEDY-SMYSKPEDFVADFRLIFQNCAEFNEP-----------------DSEV TIF1_Spur LSTIKSKLSLTSPNKYFSPRQMVEDLRVMFTNCYQYNGE-----------------TSDL bon_Dmel LDVIRTRLDPSSPNHYKDIAGFVSDVRLIFSNTYLFYQE-----------------DTKT TIF1a_Mmus LSTIKKRLQEDY-CMYTKPEDFVADFRLIFQNCAEFNEP-----------------DSEV TIF1b_Mmus LTLIRARLQEKLSPPYSSPQEFAQDVGRMFKQFNKLTED-----------------KADV TIF1g_Mmus LSTVKKKLQKKHSQHYQIPDDFVADVRLIFKNCERFNEMMKVVQVYADTQEINLKGDSEV TIF1D_Hsap LSIIRRKLQKKDPAHYTTPEEVVSDVRLMFWNCAKFNYP-----------------DSEV TIF1D_Mmus LSIIRRKLQKKDPAHYTTPEEVVSDVRLMFWNCAKFNYP-----------------DSEV * :: :*. * .. *. :* : :. TIF1g_Hsap AQAGKAVALYFEDKLTEIYSD---RTFAPLPEFEQEEDDGE------------------- TIF1b_Hsap -QSIIGLQRFFETRMNEAFGD---TKFSA-VLVEPPPMSLP------------------- TIF1a_Hsap ANAGIKLENYFEELLKNLYPE---KRFPK-PEFRNESEDNK------------------- TIF1_Spur GKIAQHLQRYASRFMKRYLPEYMDSNFVSSANQR--HE---------------------- bon_Dmel YSNAKYLENFFEEQLAKWLPQ---FEGTK-PQGKRNTSNSPALLGVNATGSPSPIENGRK TIF1a_Mmus ANAGIKLESYFEELLKNLYPE---KRFPK-VEFRHEAEDCK------------------- TIF1b_Mmus -QSIIGLQRFFETRMNDAFGD---TKFSA-VLVEPPPLNLP------------------- TIF1g_Mmus AKAGKAVALYFEDKLSEIYSD---RTFTPLPEFEQDEDDGE------------------- TIF1D_Hsap AEAGRCLEVFFEGWLKEIYPE---KRFAQ-PRQED-SDSEE------------------- TIF1D_Mmus AEAGRCLEVFFEGWLKEIYPD---KCFAQ-PQQED-SDSED------------------- . : : . : : . TIF1g_Hsap ---VT--EDSD-------------EDFIQPRRKRLKSDER-P----------VHIK TIF1b_Hsap ---GA--GLSS-------------QEL----------SGG-P----------GDGP TIF1a_Hsap ---FS--DDSD-------------DDFVQPRKKRLKSIEE-R----------QLLK TIF1_Spur ---------------------------DRPNKRRKQEHPT-P---------VFHIR bon_Dmel SCGSASLGDSD-------------GACLPAKRARRSA-----------------HE TIF1a_Mmus ---FS--DDSD-------------DDFVQPRKKRLKSTED-R----------QLLK TIF1b_Mmus ---SA--GLSS-------------QEL----------S-G-P----------GDGP TIF1g_Mmus ---VT--EDSD-------------EDFIQPRRKRLKSDER-P----------VHIK TIF1D_Hsap ---VS--SESGCSTPQGFPWPPYMQEGIQPKRRRRHMENERAKRMSFRLANSISQV TIF1D_Mmus ---VS--GESGCSTPQGFPWPPYMQEGIQPKRRRRHMENEKTKRVSFRLANSISQV