CLUSTAL W (1.83) multiple sequence alignment TLK2_Hsap MME--------------------------------------------------------- TLK1_Hsap MSVQ--------SSSGSLEGPPSWS-------QLSTS----------------------- C07A9.3_Cele MSMLS--------MDGIVAGGGSSSGGGERSFVLEQK----------------------- TLK1_Mmus MSVQ--------SSSGSLEGPPSWS-------RLSTS----------------------- TLK2_Mmus MME--------------------------------------------------------- 19858_Tthe MNKID--------NQN----------IAEKIQLLEQRISKNGQATIQSSFKQNIESLQDQ 4269_Tthe MQIDQ--------RK--------------KLELLDYRMRHPSTSPIK--------TI--- TLK_Spur MASGP------------------------------------------------------- tlk_Dmel MSPGAHLQMSPQNTSSLSQHHPHQQ-------QQLQP----------------------- AqueK208_Aque MEATDE----------LIEDTPFRS-------SQGSG----------------------- TLK-1_Smoe MHDNVLLHLSSN--SNHSD----------------------------------------- TLK-2_Smoe MHDNVLLHLSSN--SNHSD----------------------------------------- * TLK2_Hsap ------------------------------------------------ELHSLD------ TLK1_Hsap ---PTPGSAAAARSLLNHTPP---SGRPREGA--------M------DELHSLD------ C07A9.3_Cele -------------------------------------------------MFNTG------ TLK1_Mmus ---PTPGSAAAARSLLNHTPP---SGRPREGA--------M------DELHSLD------ TLK2_Mmus ------------------------------------------------ELHSLD------ 19858_Tthe TTESFKGSANNGMTQQNSVENSQLE-KNNQASSNKENVKEE------EEIQSV------- 4269_Tthe ------NNFANIKQKLNGIDI---Y-KNNNEQ--------L------KDLHDNEEDDDDK TLK_Spur ------------------------------------------------------------ tlk_Dmel ---PQQ----QQQHFPNHH-----------SA--------QQQSQQQQQQEQQN------ AqueK208_Aque ---T------GLNFTLNDN-----------SA--------S------FELETLD------ TLK-1_Smoe ----------------------------------------------------SL------ TLK-2_Smoe ----------------------------------------------------SL------ TLK2_Hsap --------P---------------------------------------RRQ-----ELLE TLK1_Hsap --------P---------------------------------------RRQ-----ELLE C07A9.3_Cele --------P---------------------------------------QNK-----ALPT TLK1_Mmus --------P---------------------------------------RRQ-----ELLE TLK2_Mmus --------P---------------------------------------RRQ-----ELLE 19858_Tthe ---------------------------------------------L-NKKG-----DYYE 4269_Tthe SEQDDYLNF------------------------------------D-DNQNNQGSLDFMN TLK_Spur ------------------------------------------------------------ tlk_Dmel --------PQQQAQQQQQILPHQHLQHLHKHPHQLQLHQQQQQQLHQQQQQ-----HFHQ AqueK208_Aque --------P---------------------------------------QKR-----ELLE TLK-1_Smoe --------P---------------------------------------SKL-----AKLE TLK-2_Smoe --------P---------------------------------------SKL-----AKLE TLK2_Hsap ARFTGVGVS--------------------------------------------------- TLK1_Hsap ARFTGVASGS--------------------TGSTGSCSV--------------------- C07A9.3_Cele VQSSGSSSNHAPIVGESPLGTVSSTMATGDTGRVGNVTYMSSGMLGATQFMPQNSSHPST TLK1_Mmus ARFTGVATGS--------------------TGSTGSCSV--------------------- TLK2_Mmus ARFTGVGVS--------------------------------------------------- 19858_Tthe KQFY-------------------------------------------------------- 4269_Tthe KNLSGFNNGG----------------------NFLYCTP--------------------- TLK_Spur ------------------------------------------------------------ tlk_Dmel QSLQGLHQGS-------------------------------------------------- AqueK208_Aque ARFMGRSLPM-------------------------------------------------- TLK-1_Smoe ARMAGKSIPA-------------------------------------------------- TLK-2_Smoe ARMAGKSIPA-------------------------------------------------- TLK2_Hsap ------------------------------------------------------------ TLK1_Hsap ------------------------------------------------------------ C07A9.3_Cele SVMMQQVPPQNGGATRSSPTEMQQCMQAMSEDSIEMRDYNSGVHHMHPHQMQMQQQQQHH TLK1_Mmus ------------------------------------------------------------ TLK2_Mmus ------------------------------------------------------------ 19858_Tthe ------------------------------------------------------------ 4269_Tthe ------------------------------------------------------------ TLK_Spur ------------------------------------------------------------ tlk_Dmel ------------------------------------------------------------ AqueK208_Aque ------------------------------------------------------------ TLK-1_Smoe ------------------------------------------------------------ TLK-2_Smoe ------------------------------------------------------------ TLK2_Hsap ------------------------------------------------------------ TLK1_Hsap ------------------------------------------------------------ C07A9.3_Cele QQQYNMSYHNHQQQMQQMHYHQQQQQYQQQQAQHHQMYAPQIQQQQQQPQQQSQQQSAQQ TLK1_Mmus ------------------------------------------------------------ TLK2_Mmus ------------------------------------------------------------ 19858_Tthe ------------------------------------------------------------ 4269_Tthe ------------------------------------------------------------ TLK_Spur ------------------------------------------------------------ tlk_Dmel ------------------------------------------------------------ AqueK208_Aque ------------------------------------------------------------ TLK-1_Smoe ------------------------------------------------------------ TLK-2_Smoe ------------------------------------------------------------ TLK2_Hsap ----K--GPLNSESSNQS--------------------LCSVGSLSD------------- TLK1_Hsap --GAK--ASTNNESSNHS--------------------FGSLGSLSD------------- C07A9.3_Cele PQQSSAALQHVNESSNLS----------------------SAGSISD------------- TLK1_Mmus --GAK--ASTNNESSNHS--------------------FGSLGSLSD------------- TLK2_Mmus ----K--GPLNSESSNQS--------------------LCSVGSLSD------------- 19858_Tthe ------------ESSNLQ--------------------IGQVMHKMD------------- 4269_Tthe --P--VKIN-NNYGNNPSILNNPHLIKSFNEENNDLDQQNSSENNSD------------- TLK_Spur ------------------------------------------------------------ tlk_Dmel ---------S-NPDSNMS--------------------TGSSHSEKDVNDMLSGGAATPG AqueK208_Aque --------TI-NTDSNIS--------------------AGSSEHDSE------------- TLK-1_Smoe ----A--KPLP-DAS-----------------------PSSTDSDEDN------------ TLK-2_Smoe ----A--KPLP-DAS-----------------------PSSTDSDEDN------------ TLK2_Hsap ----------------------------------------------KEVE----TPEKKQ TLK1_Hsap ----------------------------------------------KESE----TPEKKQ C07A9.3_Cele ----------------------------------------------REPEQHGGTPQRPT TLK1_Mmus ----------------------------------------------KESE----TPEKKQ TLK2_Mmus ----------------------------------------------KEVE----TPEKKQ 19858_Tthe ----------------------------------------------EVAE----QLEQL- 4269_Tthe ----------------------------------------------EEER----EIEE-- TLK_Spur --------------------------------------------------------VYRT tlk_Dmel AAAAAIQQQHPAFAPTLGMQQPPPPPPQHSNNGGEMGYLSAGTTTTTSVL----TVGKPR AqueK208_Aque ----------------------------------------------PQTS----QPEKPK TLK-1_Smoe ----------------------------------------AGDFMIQASA----SSQKRK TLK-2_Smoe ----------------------------------------AGDFMIQASA----SSQKRK TLK2_Hsap ------ND-QRNRKRKAE--PY-ETSQG-------------------------------- TLK1_Hsap ------SESSRGRKRKAE--NQNESSQG-------------------------------- C07A9.3_Cele APQSSTATDKKTRKRRK-AGPT-E-DQ--------------------------------- TLK1_Mmus ------SESSRGRKRKAE--SQNESSQG-------------------------------- TLK2_Mmus ------ND-QRNRKRKAE--PY-DTSQG-------------------------------- 19858_Tthe ----EQDD-EENQENKSNKNNQ-HQSNGQGLLNSDNIWDKQNSNQEGNYQNDTDEFYAPQ 4269_Tthe ----DENV-SS------------------------------------------------- TLK_Spur -------NDQRSRQE--------------------------------------------- tlk_Dmel ------TPAERKRKRKMP--PCATSADE-------------------------------- AqueK208_Aque ------P--PRARKRQLSEENGPSSKTG-------------------------------- TLK-1_Smoe ------T-FQMDESREVS--EWTVTRKS-------------------------------- TLK-2_Smoe ------T-FQMDESREEE--KLDQEGRT-------------------------------- TLK2_Hsap ------------------------------------------------------------ TLK1_Hsap ------------------------------------------------------------ C07A9.3_Cele ------------------------------------------------------------ TLK1_Mmus ------------------------------------------------------------ TLK2_Mmus ------------------------------------------------------------ 19858_Tthe EKLSDFSSMNILEAKDMQQQQLLKIPQPQIQQQNMLQVQQQLEQSDRHQQQQNAILQQGI 4269_Tthe -------------------------------------NNEELEEDDSNQDQQESLEKDAS TLK_Spur ------------------------------------------------------------ tlk_Dmel ------------------------------------------------------------ AqueK208_Aque ------------------------------------------------------------ TLK-1_Smoe ------------------------------------------------------------ TLK-2_Smoe ------------------------------------------------------------ TLK2_Hsap ------------------------------------------------------------ TLK1_Hsap ---------------------F----------------------------P--------- C07A9.3_Cele ------------------------------------------------------------ TLK1_Mmus ------------------------------------------------------------ TLK2_Mmus ------------------------------------------------------------ 19858_Tthe TTNQSTG-GASSLGQK-GTQ-------------------------------NTNTP---- 4269_Tthe -SQQSIKNEKQNKSQVSQIEKS----------------------------QKQQPPQKAE TLK_Spur ------------------------------------------------------------ tlk_Dmel --------------------AGSGGGSGGAGATVVNNSSLKGKSLAFRDMP--------- AqueK208_Aque --------------------KS----------------------------P--------- TLK-1_Smoe ------------------------------------------------------------ TLK-2_Smoe ------------------------------------------------------------ TLK2_Hsap ------------------------------------------------------------ TLK1_Hsap ------------------------------------------------------------ C07A9.3_Cele ------------------------------------------------------------ TLK1_Mmus ------------------------------------------------------------ TLK2_Mmus ------------------------------------------------------------ 19858_Tthe ---VMQ------NSREKYQKSTGKKRRTTQTTLAMNKLKKYDT--TTPCPSIVQIQNTNQ 4269_Tthe NFEPTIKKVRVLNSQKILFQENTFPNENEKPINQQSGQSGEQVKKTEDIKNIVNQI--GL TLK_Spur ------------------------------------------------------------ tlk_Dmel ------------------------------------------------------------ AqueK208_Aque ------------------------------------------------------------ TLK-1_Smoe ------------------------------------------------------------ TLK-2_Smoe ------------------------------------------------------------ TLK2_Hsap ------------------------------------------------------------ TLK1_Hsap ---------------------NLPVFQSLAYWEMGRTA------------------G--- C07A9.3_Cele ------------------------------------------------------------ TLK1_Mmus ------------------------------------------------------------ TLK2_Mmus ------------------------------------------------------------ 19858_Tthe VSNRPRLNSESSNSNEAIQLNN-------------------------------------- 4269_Tthe IQVKNAAK-----------NNN-------------------------------------- TLK_Spur ------------------------------------------------------------ tlk_Dmel ---------------------KVNMSLN-LGDRLGGSAGSGVGAGGAGSGGGGAGSGSGS AqueK208_Aque ------------------------------------------------------------ TLK-1_Smoe ------------------------------------------------------------ TLK-2_Smoe ------------------------------------------------------------ TLK2_Hsap ---KG-----T-PRGHKISDYFEFAGG---------SAPGTSPGRS-------------- TLK1_Hsap --GKS-----IGGRGHKISDYFEYQGG---------N--GSSPVRG-------------- C07A9.3_Cele ----A-----TPKQERKITEFMKVGGE---------VASGNSVARC-------------- TLK1_Mmus ---KS-----IGGRGHKISDYFEYQGG---------N--GSSPVRG-------------- TLK2_Mmus ---KG-----T-PRGHKISDYFEFAGG---------SGPGTSPGRS-------------- 19858_Tthe ----V-----PPPGNSKITQFFKMKNT---------PTQNTTAISG-------------- 4269_Tthe ----K-----TQKKISKITDYLNQDQV---------NK-N-------------------- TLK_Spur ------------------------------------------------------------ tlk_Dmel GGGKSARLMLPVSDNKKINDYFNKQQTGVGVGVPGGAGGNTAGLRGSHTGGGSKSPSSAQ AqueK208_Aque ----------KMDPSKKISEYFPSKGT---------SGTNSS------------------ TLK-1_Smoe ---WI------TKAGQ-QR----AAEE--------------------------------- TLK-2_Smoe ---TK------SSRGMGQR----SRGG--------------------------------- TLK2_Hsap -------------------------------------VPPVARSSPQHSLSNPLPRRVEQ TLK1_Hsap -------------------------------------IPPAIR-SPQNSHSHSTPSS--- C07A9.3_Cele -------------------------------------LLTEYH-QNQ-----GSPK--RQ TLK1_Mmus -------------------------------------IPPAIR-SPQNSHSHSTPSS--- TLK2_Mmus -------------------------------------VPPVARSSPQHSLSNPLPRRAEQ 19858_Tthe -------------------------------------QPLN-NLNSQPQQQNQINNQAPQ 4269_Tthe ------------------------------------------------------------ TLK_Spur ------------------------------------------------------------ tlk_Dmel QQQTAAQQQGSGVATGGSAGGSAGNQVQVQTSSAYALYPPAS-PQTQTSQQ----QQQQQ AqueK208_Aque ------------------------------------------------------------ TLK-1_Smoe ------------------------------------------------------------ TLK-2_Smoe ------------------------------------------------------------ TLK2_Hsap PLYGLDGSAAKEATEEQSALPTL-------MSVMLAKPRLDTEQLAQRGAGLCFTFVSAQ TLK1_Hsap ---------------------------------------------------------SVR C07A9.3_Cele PAVQQNGSNSYDSQQQQ---PQM-------NQHEM-Q---------NSYWGVATPSLGVN TLK1_Mmus ---------------------------------------------------------SVR TLK2_Mmus PLYGLDGSAAKEASEEQSALPTL-------MSVMLAKPRLDTEQLAPRGAGLCFTFVSAQ 19858_Tthe TPSQQNGQQ---VSQK-----EN-------INIQVLPPQ-----NL--SNGQSLQTPSIS 4269_Tthe ------------------------------------------------------------ TLK_Spur ------------------------------------------------------------ tlk_Dmel PGSDFHYVNSSKAQQQQQRQQQQ-------TSNQMVPPHV-----VVGLGGHPLSLASIQ AqueK208_Aque ------------------------------------------------------------ TLK-1_Smoe --------WANEAGVEKQKRPSV-------LTHHLLQ-----------------R----- TLK-2_Smoe --------KAKEAKR-PHSPPSAKVDFSFLFSLSVLY-----------------RFLK-- TLK2_Hsap -QNSPSST-----------------------------------------------GSGNT TLK1_Hsap -PNSPSPT-----------------------------------------------ALAFG C07A9.3_Cele NRGTPTPTQQQHYSSD---------------------------------------SNSNS TLK1_Mmus -PNSPSPT-----------------------------------------------ALAFG TLK2_Mmus -QNSPSST-----------------------------------------------GSGNT 19858_Tthe QYNTPMATQNNSNYPNTNKKSVQNTSNGMMIDENKIQQNGALAHLQSPSQSVSSIANANS 4269_Tthe -------ANNNN---------------------------------------MFSKSTGNS TLK_Spur ------------------------------------------------------------ tlk_Dmel -QQTPLSQ-----------------------------------------------QQQQQ AqueK208_Aque ----C-SQ---------------------------------------------------- TLK-1_Smoe ----------------------------------------------------------LT TLK-2_Smoe ----------------------------------------------------------VD TLK2_Hsap EHSCSS-Q---------------------------------------------------- TLK1_Hsap DHPIVQ-P---------------------------------------------------- C07A9.3_Cele NQSPPGQG---------------------------------------------------- TLK1_Mmus DHPVVQ-P---------------------------------------------------- TLK2_Mmus EHSCSS-Q---------------------------------------------------- 19858_Tthe TNSNVQ------------------------------------------------------ 4269_Tthe NNTET------------------------------------------------------- TLK_Spur ------------------------------------------------------------ tlk_Dmel QQQ-QQQQQLGPPTTSTASVVPTHPHQLGSLGVVGMVGVGVGVGVGVNVGVGPPLPPPPP AqueK208_Aque -------T---------------------------------------------------- TLK-1_Smoe TGMVRN-T---------------------------------------------------- TLK-2_Smoe NGNGAE-H---------------------------------------------------- TLK2_Hsap ----KQI----SIQHRQTQSDLTIEKISALENSKNSDLEKKEGRIDDLLRANCDLRRQID TLK1_Hsap ----KQL----SF--KIIQTDLTMLKLAALESNKIQDLEKKEGRIDDLLRANCDLRRQID C07A9.3_Cele ----NQSGRMVRTIDEETQTDSSLSQAN----PQNAD------EVAKMNRIIEDHRRQIE TLK1_Mmus ----KQL----SF--KITQTDLTMLKLAALESTKNQDLEKKEGRIDDLLRANCDLRRQID TLK2_Mmus ----KQI----SIQHRQTQSDLTIEKISALENSKNSDLEKKEGRIDDLLRANCDLRRQID 19858_Tthe -----QN----STSS--HHQHYNQLKLSSSNQMKIYD-PK-------LENRYQDLQEEIK 4269_Tthe -------------------------------------------------EQIQLLNRELK TLK_Spur ------------------------------------------------------------ tlk_Dmel MAMPAAI--IT--YSKATQTEVSLHELQEREA----EHESGKVKLDEMTRLSDEQKSQIV AqueK208_Aque ----RLV--FTSSNTAQTQTDINLERLKKLEKSTSQYEEDKE-----------LLQERVT TLK-1_Smoe ----RDV----L-WSKFSTEDHW---IICWCAGLGEELDKARSEACQYQRTCQQLEKEIN TLK-2_Smoe ----KRF----S-EDERLKEDLM--TLNARCAGLGEELDKARSEACQYQRTCQQLEKEIN TLK2_Hsap EQ--QKMLEKYKERL-----------------------------------NRCVTMSKKL TLK1_Hsap EQ--QKLLEKYKERL-----------------------------------NKCISMSKKL C07A9.3_Cele ELNSKNSLERRKNEA-----------------------------------SK--ETIKRL TLK1_Mmus DQ--QKLLEKYKERL-----------------------------------NKCISMSKKL TLK2_Mmus EQ--QKMLEKYKERL-----------------------------------NRCVTMSKKL 19858_Tthe Q--KELELNEKNNII------------------------------------KYLEQD-KT 4269_Tthe E--KEQQLNQKQKQIENLENLVGKLKQSLQNAKSTNTSGQNSLNPTIFDHSKIKRIVQKM TLK_Spur -------------------------------------------------------EVFKL tlk_Dmel GN--QKTIDQHKCHI-----------------------------------AKCIDVVKKL AqueK208_Aque QL--EAILSNSSDK---------------------------------------IELLTG- TLK-1_Smoe DM-KEVQLEKERKRL---------------------------------------KVVSDL TLK-2_Smoe DM-KEVQLEKERKRL---------------------------------------KVVSDL TLK2_Hsap LIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASFTEQWTDGYAFQNLIKQQERINSQRE TLK1_Hsap LIEKSTQEKLSSREKSMQDRLRLGHFTTVRHGASFTEQWTDGFAFQNLVKQQEWVNQQRE C07A9.3_Cele LIDKNQIERKALRDKTAADSPRIGCFKTTRTGDSFRDQWVDGWAFAEMDKKTEQINAERN TLK1_Mmus LIEKSTQEKLSSREKSMQDRLRLGHFTTVRHGASFTEQWTDGFAFQNLVKQQEWVNQQRE TLK2_Mmus LIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASFTEQWTDGYAFQNLIKQQERINSQRE 19858_Tthe LLEVEKLKREEMRQYIAKEKQRLGEYVQTRDCTKFDETWQEGTEFKKIKERLRVIEAEKE 4269_Tthe FTENSFLNRKLIKMQLQQSKQRLGEYVVDL--QNFKEQWIDGFEVQELYSQLDQVQKKIK TLK_Spur V--VAATENKQARTKSMEDRLRLGQFTTQRQGAKFVETWNDGYAFTDLVKRQEKIAKERE tlk_Dmel LKEKSSIEKKEARQKCMQNRLRLGQFVTQRVGATFQENWTDGYAFQELSRRQEEITAERE AqueK208_Aque KISKSTATKKEQREESVRNQLRLGRFSAQRQGAHFVDTWIDGFAFQELSQEQNDISVQKE TLK-1_Smoe LIAVAKGERQEARLRVRQDSVRLGNVGVMRAGTLLSEVWEDGQALKDIQARLKSLLEQKD TLK-2_Smoe LIAVAKGERQEARLRVRQDSVRLGNVGVMRAGTLLSEVWEDGQALKDIQARLKSLLEQKD . : . *:* : : * :* . .: . : : . TLK2_Hsap EIERQRKMLAKRKPPAMG--QA-PPA-T----NEQKQRK------SK-TNG-A------- TLK1_Hsap DIERQRKLLAKRKPPTANNSQA-PST-N----SEPKQRK------NKAVNG-A------- C07A9.3_Cele EIASASALLKKRKPLGIGKEPKRPQAVNSQNDSNGMQPS------TS-SNTNG------- TLK1_Mmus DIERQRKLLGKRKPPTANNSQA-PAT-N----SEAKQRK------TKAVNG-A------- TLK2_Mmus EIERQRKMLAKRKPPAMG--QA-PPA-T----NEQKQRK------SK-TNG-A------- 19858_Tthe ELEKKKKNVKG---SRKST--------N---ETDI------------------------- 4269_Tthe YYQNVLQNLKTMKPKKKTQ--------T---NGKQ--QK------QLTLLG-S------- TLK_Spur ELDQQRKSLMKRKPPNSPH------------PSSKSR---------PKQNG-P------- tlk_Dmel EIDRQKKQLMKKRPAESGRKRN-NNS-N---QNNQQQQQQQHQQQQQQQNSNSNDSTQLT AqueK208_Aque EIEKQKKLLAAKKKIVSSS------------GSKRAG---------KSSPT-L------- TLK-1_Smoe AIEKQRKLLKKKQNDKT--------------------------------DA-S------- TLK-2_Smoe AIEKQRKLLKKKQNDKT--------------------------------DA-S------- : TLK2_Hsap ------------------------------------------------------------ TLK1_Hsap ------------------------------------------------------------ C07A9.3_Cele ------------------------------------------------------------ TLK1_Mmus ------------------------------------------------------------ TLK2_Mmus ------------------------------------------------------------ 19858_Tthe ------------------------------------------------------------ 4269_Tthe ------------------------------------------------------------ TLK_Spur ------------------------------------------------------------ tlk_Dmel SGVVTGPGSDRVSVSVDSGLGGNNAGAIGGGTVGGGVGGGGVGGGGVGGGGGRGLSRSNS AqueK208_Aque ------------------------------------------------------------ TLK-1_Smoe ------------------------------------------------------------ TLK-2_Smoe ------------------------------------------------------------ TLK2_Hsap -------------------------------------------------ENETPSSGNTE TLK1_Hsap -------------------------------------------------ENDPFVR---- C07A9.3_Cele -------------------------------------------------DDAIFRR---- TLK1_Mmus -------------------------------------------------ENDPFVR---- TLK2_Mmus -------------------------------------------------ENE-------- 19858_Tthe ------------------------------------------------------------ 4269_Tthe -------------------------------------------------LNDPSTQ---- TLK_Spur -------------------------------------------------NDEGFAK---- tlk_Dmel TQANQAQLLHNGGGGSGGNVGNSGGVGDRLSDRGGGGGGIGGNDSGSCSDSGTFLK---- AqueK208_Aque -------------------------------------------------DSDGFTK---- TLK-1_Smoe -------------------------------------------------ES--------- TLK-2_Smoe -------------------------------------------------EN--------- TLK2_Hsap LKDTAPALGAH-SLL----------------RLT--L-AEYHEQEEIFKLRLGHLKKEEA TLK1_Hsap ---------PN-LPQ----------------LLT--L-AEYHEQEEIFKLRLGHLKKEEA C07A9.3_Cele ---------PE-EPK----------------EIQ--Y-QEYIELDEIYKLRREHLRKEET TLK1_Mmus ---------PN-LPQ----------------LLT--L-AEYHEQEEIFKLRLGHLKKEEA TLK2_Mmus -------------------------------TLT--L-AEYHEQEEIFKLRLGHLKKEEA 19858_Tthe -------------SQ---------------------E-LDLAEQKQRINLQIQFLQKEEA 4269_Tthe ---------AN-SNQDSNSKLTFEDEDEFDTSIYPNQAVAHEEQKRFTAFQITLLQKQEE TLK_Spur ---------PL--PE----------------YMN--H-AEFYERDEITKLRQAAFKKEES tlk_Dmel ---------PDPVSG----------------AYT--A-QEYYEYDEILKLRQNALKKEDA AqueK208_Aque ---------PQ--AP----------------GIS--M-SEFLEKDEILKLRGAALKKEDL TLK-1_Smoe -------------DQ----------------GLA--E-EECIATEEMYRARIFSIKREEE TLK-2_Smoe -------------DQ----------------GLA--E-EECIATEEMYRARIFSIKREEE .. : ::::: TLK2_Hsap EIQAELERLERVRNLHIRELKRIHNEDNSQF-KDHPTLNDRYLLLHLLGRGGFSEVYKAF TLK1_Hsap EIQAELERLERVRNLHIRELKRINNEDNSQF-KDHPTLNERYLLLHLLGRGGFSEVYKAF C07A9.3_Cele DLSMEKERLEKEKQHHVRELKRASNESASQF-NDHRLLHKRYLMLNLLGKGGFSEVWKAF TLK1_Mmus EIQAELERLERVRNLHIRELKRINNEDNSQF-KDHPTLNERYLLLHLLGRGGFSEVYKAF TLK2_Mmus EIQAELERLERVRNLHIRELKRIHNEDNSQF-KDHPTLNDRYLLLHLLGRGGFSEVYKAF 19858_Tthe DLIEMYKNLDHEKFLFVQKLKRFQDEQNSRYGQEWPCLGERYQLLSLLGRGGFSEVYKAY 4269_Tthe VIVNNLNQKKK----EVKEIIKNSRYGGIQVENPWPILGERYQLLSLLGKGGFSEVYKAI TLK_Spur DLQGELEKLERERNLHIRELKRIHNEDQSTF-KNHKVLNDRYLLLRLLGKGGFSEVYKGY tlk_Dmel DLQLEMEKLERERNLHIRELKRILNEDQSRF-NNHPVLNDRYLLLMLLGKGGFSEVHKAF AqueK208_Aque NILQLREKLERERNLHIRELKRIAAEDNSRF-NDHPVLHNRYLLLHLIGKGGFSEVHK-- TLK-1_Smoe NTLRDRERYELEKACFIRELKRIRDEDGSRF-NHFPILNKRYALLNLLGKGGFSEVYKAY TLK-2_Smoe NTLRDRERYELEKACFIRELKRIRDEDGSRF-NHFPILNKRYALLNLLGKGGFSEVYKAY :. . :::: : : * .** :* *:*:****** * TLK2_Hsap DLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSF TLK1_Hsap DLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDTF C07A9.3_Cele DIEENRYVACKIHHVNKDWKEEKKANYVKHAMREKDIHKSLDHCRIVKQYDLLTIDNHSF TLK1_Mmus DLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDTF TLK2_Mmus DLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSF 19858_Tthe DLHEFKEVACKIHQLNLNWSEPSKANYIKHAVRESKIHSELKHANIVQLYDTVEIDNNSF 4269_Tthe DLEEFREVAIKIHYIDKSWSNRVKQNYLKHAFREHGIQKELNHPNIVKLYDYIEIDSTSF TLK_Spur DLKDHRDVACKIHQLSKEWKEDKKANYIKHALREYEIHKSLDHARVVKLYDVFEIDANSF tlk_Dmel DLKEQRYVACKVHQLNKDWKEDKKANYIKHALREYNIHKALDHPRVVKLYDVFEIDANSF AqueK208_Aque --------------------------------------------HIVQLYDVFEIDADSF TLK-1_Smoe DMVEYRYVACKLHGLNVQWSEEKKQNYIRHAIREYNIHKSLVHSHIVRLWDIFEIDHNTF TLK-2_Smoe DMVEYRYVACKLHGLNVQWSEEKKQNYIRHAIREYNIHKSLVHSHIVRLWDIFEIDHNTF .:*: :* . :* :* TLK2_Hsap CTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILL TLK1_Hsap CTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLNEIKPPIIHYDLKPGNILL C07A9.3_Cele CTVLEYVPGNDLDFYLKQNRSISEKEARSIIMQVVSALVYLNEKSTPIIHYDLKPANILL TLK1_Mmus CTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLNEIKPPIIHYDLKPGNILL TLK2_Mmus CTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILL 19858_Tthe ATILEYCEGPDLYFYLKKHKVLPEKEAKILIRQILCALRYMNSLKTRIIHYDLKPQNIIF 4269_Tthe ASVLQFCEGPDLSQHLKIHSTIIEQDAKYIVKKILECLEYLSSFQSKVIHYDLKPQNIIF TLK_Spur CTVLEFCPGNDLDFHLKQHKLMVEREARCIIMQVVSALKYLNERKPPIIHYDLKPGNILL tlk_Dmel CTVLEYCDGHDLDFYLKQHKTIPEREARSIIMQVVSALKYLNEIKPPVIHYDLKPGNILL AqueK208_Aque CTVLEFVSGNDLDFLLKQNKTLPEKEARSVVVQTLTALKYLNEIRPPIIHFDLKPGNILL TLK-1_Smoe CTVLQYCGGKDLDAVLKSTSVLPEREARSIMVQIFSGLVYLNRRSQRVIHYDLKPGNVLF TLK-2_Smoe CTVLQYCGGKDLDAVLKSTSVLPEREARSIMVQIFSGLVYLNRRSQRVIHYDLKPGNVLF .::*:: * ** ** : *::*: :: : . * *:. :**:**** *::: TLK2_Hsap VNGTACGEIKITDFGLSKIMDDDSYNSV-DGMELTSQGAGTYWYLPPECFVV-----GKE TLK1_Hsap VDGTACGEIKITDFGLSKIMDDDSYG-V-DGMDLTSQGAGTYWYLPPECFVV-----GKE C07A9.3_Cele ESGNTSGAIKITDFGLSKIMEGESDDH-DLGIELTSQFAGTYWYLPPETFIV-------P TLK1_Mmus VDGTACGEIKITDFGLSKIMDDDSYG-V-DGMDLTSQGAGTYWYLPPECFVV-----GKE TLK2_Mmus VNGTACGEIKITDFGLSKIMDDDSYNSV-DGMELTSQGAGTYWYLPPECFVV-----GKE 19858_Tthe HK----GELKISDFGLSKIFDDGQ-----TRMELTSQGVGTYWYLPPETFEF------EN 4269_Tthe HK----GQIKITDFGLSKIIEDNA-----TRLELTSQGVGTYWYLPPECFENFGCEENEK TLK_Spur CHGSTCGAIKLTDFGLSKVMDDEHFNSQEGGMDLTSQGAGTYWYLPPECFVV-----GKE tlk_Dmel TEGNVCGEIKITDFGLSKVMDDENYNP-DHGMDLTSQGAGTYWYLPPECFVV-----GKN AqueK208_Aque GSGIYSYEAKITDFGLSKIVEQEG---TDGMVELTSQGAGTYWYLPPECFVI-----GKE TLK-1_Smoe DE---AGAAKLTDFGLSKIVEDEV-G-S-QGMELTSQGAGTYWYLPPECFDV-----NK- TLK-2_Smoe DE---AGAAKLTDFGLSKIVEDEV-G-S-QGMELTSQGAGTYWYLPPECFDV-----NK- *::******:.: ::**** .********* * TLK2_Hsap PPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATEVQFPPKPVVTPEA TLK1_Hsap PPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATEVQFPVKPVVSSEA C07A9.3_Cele PPKITCKVDVWSIGVIFYQCIYGKKPFGNDLTQQKILEYNTIINAREVSFPSKPQVSSAA TLK1_Mmus PPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATEVQFPVKPVVSSEA TLK2_Mmus PPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATEVQFPPKPVVTPEA 19858_Tthe SALISPKVDIWSVGVIFFEMVFGQRPFGNNKSQDQILKENIILKSTSVTFPSKPSVSNEC 4269_Tthe APTISNKVDIWSVGVIFYEMLFGQKPFGNKMTQEQILRQNTILNSKEVKFPKKPLISKEA TLK_Spur PPKISSKVDVWSTGIIFYQCLYGKKPFGHNLSQASILEQNTILRATQVQFSPKPTVSQEA tlk_Dmel PPKISSKVDVWSVGVIFYQCLYGKKPFGHNQSQATILEENTILKATEVQFSNKPTVSNEA AqueK208_Aque PPKISSKVDVWSVGIIFFQCLYGKKPFGHNQSQASILEENVMLKATEVEFPSKPPVSNEA TLK-1_Smoe TPLISSKVDVWSAGVLFYQMLFGKRPFGHDQSQERILREDTITKARKVEFPTRPSVSADA TLK-2_Smoe TPLISSKVDVWSAGVLFYQMLFGKRPFGHDQSQERILREDTITKARKVEFPTRPSVSADA .. *: ***:** *::*:: ::*::***:. :* **. : : .: .* *. :* :: . TLK2_Hsap KAFIRRCLAYRKEDRIDVQQLACDPYLLPHIRKSVS-TSSPAGAAI-AST-S---GASNN TLK1_Hsap KAFIRRCLAYRKEDRFDVHQLANDPYLLPHMRRSNS-SGNLHMAGLTASP-T---PPSSS C07A9.3_Cele QDFIRRCLQYRKEDRADVFELAKHELFRPRGAIRASVAGSLLLVIITLCQHSNRSEDRLC TLK1_Mmus KAFIRRCLAYRKEDRFDVHQLANDPYLLPHMRRSNS-SGNLHMSGLTATP-T---PPSSS TLK2_Mmus KAFIRRCLAYRKEDRIDVQQLACDPYLLPHIRKSVS-TSSPAGAAI-AST-S---GASNN 19858_Tthe KDFIRNCLTYDQNRRWDIQKAWDSPYMNS------------------------------- 4269_Tthe QSFIIGCLKHNQEERFDVKQALNHPYFK-------------------------------- TLK_Spur KDFIRRCLMYRKEDRADVLALAKDPYLMPSNKKSSA-AAAAHASAAVSSP-QSHSNISNS tlk_Dmel ------------------------------------------------------------ AqueK208_Aque KNFIKRCLTYRKEDRPDVITIIEDLYLQPKKAPAVP----------------GHS--GSP TLK-1_Smoe KDFIRRCLSYDQMDRPDVLTAAQDPYLSYVKR---------------------------- TLK-2_Smoe KDFIRRCLSYDQMDRPDVLTAAQDPYLSYVKR---------------------------- TLK2_Hsap SSSN TLK1_Hsap IITY C07A9.3_Cele VSNV TLK1_Mmus IITY TLK2_Mmus SSSN 19858_Tthe -KTR 4269_Tthe --KA TLK_Spur ENST tlk_Dmel ---K AqueK208_Aque GPTS TLK-1_Smoe --KP TLK-2_Smoe --KP