CLUSTAL W (1.83) multiple sequence alignment TXK_Hsap MI----------------------------------------LSSYNTIQSVFCCC-CCC TEC_Hsap MN----------------------------------------FNT------ILEEILIKR ITK_Hsap MN----------------------------------------NFI------LLEEQLIKK ITK_Mmus MN----------------------------------------NFI------LLEEQLIKK BTK_Mmus MA----------------------------------------A-V------ILESIFLKR BMX_Mmus MDDNM------------------------------------ESKS------ILEELLLKK BMX_Hsap MD----------------------------------------TKS------ILEELLLKR BTK_Hsap MA----------------------------------------A-V------ILESIFLKR Btk29A_Dmel MMGTKHRNSHVNGSIKSSSSLRSSSKSFQAKMDLMSER---LYDV------VKSGSMVKR TEC_Mmus MN----------------------------------------FNT------ILEEILIKR TXK_Mmus MI----------------------------------------LSSYSSFQSVLCCCCCRC TEC_Spur MSTSGYSTG----------------------------SFSTGSFS------LDSDHGFRL AqueK442_Aque KG---------------------------------------------------------- AqueK443_Aque ------------------------------------------------------------ AqueK444_Aque ------------------------------------------------------------ AqueK445_Aque ML---------------------------------------------------------- AqueK446_Aque ------------------------------------------------------------ AqueK447_Aque MLVMEY-------------------------------------------------LPLSL AqueK448_Aque MMPVNHQSG--------------------------------ADVE------LKVDYMVKR TXK_Hsap SV--QKRQM-----------R--------------------------------------- TEC_Hsap SQ--QKKKTSPLNYKERLFVL--------------------------------------- ITK_Hsap SQ--QKRRTSPSNFKVRFFVL--------------------------------------- ITK_Mmus SQ--QKRRTSPSNFKVRFFVL--------------------------------------- BTK_Mmus SQ--QKKKTSPLNFKKRLFLL--------------------------------------- BMX_Mmus SQ--QKKKMSPNNYKERLFVL--------------------------------------- BMX_Hsap SQ--QKKKMSPNNYKERLFVL--------------------------------------- BTK_Hsap SQ--QKKKTSPLNFKKRLFLL--------------------------------------- Btk29A_Dmel AQ--NKKRFTPVNYKHRWFEL--------------------------------------- TEC_Mmus SQ--QKKKTSPLNYKERLFVL--------------------------------------- TXK_Mmus SV--QKRQV-----------R--------------------------------------- TEC_Spur SP--RRSKNPSGKKREKLKVLFDSGTESSEEGSLGLKYGGERFQLPDPVTSVPESSTPDS AqueK442_Aque ------------------------------------------------------------ AqueK443_Aque ------------------------------------------------------------ AqueK444_Aque ------------------------------------------------------------ AqueK445_Aque ------------------------------------------------------------ AqueK446_Aque ------------------------------------------------------------ AqueK447_Aque TQCLEREE-LSLQMKYSLLLD--------------------------------------- AqueK448_Aque SQ--GKSALGATNFKKRVFVL--------------------------------------- TXK_Hsap ------------------------------------------------------------ TEC_Hsap ------------------------------------------------------------ ITK_Hsap ------------------------------------------------------------ ITK_Mmus ------------------------------------------------------------ BTK_Mmus ------------------------------------------------------------ BMX_Mmus ------------------------------------------------------------ BMX_Hsap ------------------------------------------------------------ BTK_Hsap ------------------------------------------------------------ Btk29A_Dmel ------------------------------------------------------------ TEC_Mmus ------------------------------------------------------------ TXK_Mmus ------------------------------------------------------------ TEC_Spur SIPEGFDPSIEGPNEIYDIADHGSVKRNFNDLYGGIRRSTYDSIISDSGNQQEPRRGSYP AqueK442_Aque ------------------------------------------------------------ AqueK443_Aque ------------------------------------------------------------ AqueK444_Aque ------------------------------------------------------------ AqueK445_Aque ------------------------------------------------------------ AqueK446_Aque ------------------------------------------------------------ AqueK447_Aque ------------------------------------------------------------ AqueK448_Aque ------------------------------------------------------------ TXK_Hsap ------------------------------------------------------------ TEC_Hsap ------------------------------------------------------------ ITK_Hsap ------------------------------------------------------------ ITK_Mmus ------------------------------------------------------------ BTK_Mmus ------------------------------------------------------------ BMX_Mmus ------------------------------------------------------------ BMX_Hsap ------------------------------------------------------------ BTK_Hsap ------------------------------------------------------------ Btk29A_Dmel ------------------------------------------------------------ TEC_Mmus ------------------------------------------------------------ TXK_Mmus ------------------------------------------------------------ TEC_Spur RIFISHRDIPEPDYDDLPRDIPEQDYDELPRNYIPERDYDDLSQDIHVTQSRFHHATISS AqueK442_Aque ------------------------------------------------------------ AqueK443_Aque ------------------------------------------------------------ AqueK444_Aque ------------------------------------------------------------ AqueK445_Aque ------------------------------------------------------------ AqueK446_Aque ------------------------------------------------------------ AqueK447_Aque ------------------------------------------------------------ AqueK448_Aque ------------------------------------------------------------ TXK_Hsap -------------------------------TQISLSTDEEL--P-EK------------ TEC_Hsap -------------------------------TKSMLTYYEGR--A-EKKYRKGFIDVSKI ITK_Hsap -------------------------------TKASLAYFEDR--HGKKRTLKGSIELSRI ITK_Mmus -------------------------------TKASLAYFEDR--HGKKRTLKGSIELSRI BTK_Mmus -------------------------------TVHKLSYYEYDFERGRRGSKKGSIDVEKI BMX_Mmus -------------------------------TKTSLSYYEYD--KMKRGSRKGSIEIKKI BMX_Hsap -------------------------------TKTNLSYYEYD--KMKRGSRKGSIEIKKI BTK_Hsap -------------------------------TVHKLSYYEYDFERGRRGSKKGSIDVEKI Btk29A_Dmel -------------------------------TKRTFSYFDVE--NVERRRERGRIHLKGV TEC_Mmus -------------------------------TKSVLSYYEGR--A-EKKYRKGVIDISKI TXK_Mmus -------------------------------TQISLSREEEL--S-EK------------ TEC_Spur VVSKPMDTIVAKKSEARSLPIQAFLNGHLFLDVSRLPHV-----RNKRGKEKNRIDLNQI AqueK442_Aque ------------------------------------------------------------ AqueK443_Aque ------------------------------------------------------------ AqueK444_Aque ------------------------------------------------------------ AqueK445_Aque ------------------------------------------------------------ AqueK446_Aque ------------------------------------------------------------ AqueK447_Aque -------------------------------VAKGLCYLHGK--RPP---L--------- AqueK448_Aque -------------------------------TNNKLSYYDGN--LEKRGGLKGQVDLNSV TXK_Hsap ------------------------------------------------------------ TEC_Hsap KCVEIV--KNDDGVIPC-QN---------------------KYPFQ------VVHD---- ITK_Hsap KCVEIV--KSDI-SIPC-HY---------------------KYPFQ------VVHD---- ITK_Mmus KCVEIV--KSDI-SIPC-HY---------------------KYPFQTLVYLQVVHD---- BTK_Mmus TCVETV--IPEK-NPPP-ERQIPRRGEESSEMEQISIIERFPYPFQ------VVYD---- BMX_Mmus RCVEKV--NLEE-QTPV-ER---------------------QYPFQ------IVYK---- BMX_Hsap RCVEKV--NLEE-QTPV-ER---------------------QYPFQ------IVYK---- BTK_Hsap TCVETV--VPEK-NPPP-ERQIPRRGEESSEMEQISIIERFPYPFQ------VVYD---- Btk29A_Dmel RLVEEATVSGEG-GDPFAPD---------------------GYPFQ------VGYCEISA TEC_Mmus KCVEIV--KNDDGVIPC-QN---------------------KFPFQ------VVHD---- TXK_Mmus ------------------------------------------------------------ TEC_Spur KVVEPV--ADG-A----------------------------------------------- AqueK442_Aque ------------------------------------------------------------ AqueK443_Aque ------------------------------------------------------------ AqueK444_Aque ------------------------------------------------------------ AqueK445_Aque ------------------------------------------------------------ AqueK446_Aque ------------------------------------------------------------ AqueK447_Aque ----------------------------------------------------VHR----- AqueK448_Aque KVIEKV--SDSAF------D---------------------KPSFQ------VVH----- TXK_Hsap -----------------------------------------YTQRRRPWLSQLSNKKQS- TEC_Hsap --------------------------------ANTLYIFAPSPQSRDLWVKKLKEEIKN- ITK_Hsap --------------------------------NYLLYVFAPDRESRQRWVLALKEETRN- ITK_Mmus --------------------------------NYLLYVFAPDCESRQRWVLTLKEETRN- BTK_Mmus --------------------------------EGPLYVFSPTEELRKRWIHQLKNVIRY- BMX_Mmus --------------------------------DGLLYVYASNEESRCQWLKALQKEIRG- BMX_Hsap --------------------------------DGLLYVYASNEESRSQWLKALQKEIRG- BTK_Hsap --------------------------------EGPLYVFSPTEELRKRWIHQLKNVIRY- Btk29A_Dmel SANSHQLENGNGGGSGVGIEGQQSGRAVP---QYTLYVIANSEKERSEWIRAIRQVCEDS TEC_Mmus --------------------------------ANTLYIFAPSPQSRDRWVKKLKEEIKN- TXK_Mmus -----------------------------------------HSQRQRPWFAKLMGKTQS- TEC_Spur ------------------------------------------LENRQNGI-QVTYMVQA- AqueK442_Aque ------------------------------------------------------------ AqueK443_Aque ------------------------------------------------------------ AqueK444_Aque ------------------------------------------------------------ AqueK445_Aque ------------------------------------------------------------ AqueK446_Aque ------------------------------------------------------------ AqueK447_Aque ----------------------------DLTANNVLLTSSYSAKLSDLGVSRLADTFKK- AqueK448_Aque ----------------------------G---DLTLYVIADDEAQRHDWLELLRQYCRS- TXK_Hsap NTG--------RV--------------------------------Q-------------- TEC_Hsap NNN--------IMIKYHPKFWTDGSYQCCRQTEKLAPGCEKYNLFE-------------- ITK_Hsap NNS--------LVPKYHPNFWMDGKWRCCSQLEKLATGCAQYDPTK-------------- ITK_Mmus NNS--------LVSKYHPNFWMDGRWRCCSQLEKPAVGCAPYDPSK-------------- BTK_Mmus NSD--------LVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGS-L-K----P--- BMX_Mmus NPH--------LLIKYHSGFFVDGKFLCCQQSCKAAPGCTLWEAYAD--L-H----I--- BMX_Hsap NPH--------LLVKYHSGFFVDGKFLCCQQSCKAAPGCTLWEAYAN--L-H----T--- BTK_Hsap NSD--------LVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGS-L-K----P--- Btk29A_Dmel NTP--------KSYRYHPGLWSGKKWSCCKGLSRTTFGCRAAAHWREANN-N----P--- TEC_Mmus NNN--------IMIKYHPKFWADGSYQCCRQTEKLAPGCEKYNLFE-------------- TXK_Mmus NRG--------GV--------------------------------Q-------------- TEC_Spur NSN--------LSDRYHYGIWT-TKWTCCQKDYKGAPGCQNTFRQQPQ-P-Q----H--- AqueK442_Aque ------------------------------------------------------------ AqueK443_Aque ------------------------------------------------------------ AqueK444_Aque ------------------------------------------------------------ AqueK445_Aque ------------------------------------------------------------ AqueK446_Aque ------------------------------------------------------------ AqueK447_Aque DHLTTAPGNASVMP----PEALEDNPVYDHKLDVFSYGCLLLHVLTGQ-LP--------K AqueK448_Aque NGK--------LQDFYHPGLFVNSKWSCCDHKSKHSTGCSPAFIKDEHQFSQGAASFGSS TXK_Hsap ---------PSKRKPL-------------------------------------------- TEC_Hsap ---------SSIRKALPPA----------------------------------------- ITK_Hsap ---------NASKKPLPPT----------------------------------------- ITK_Mmus ---------NASKKPLPPT----------------------------------------- BTK_Mmus -----GSSHRKTKKPLPPT----------------------------------------- BMX_Mmus -----AISDEKHRA--PTF----------------------------------------- BMX_Hsap -----AVNEEKHRV--PTF----------------------------------------- BTK_Hsap -----GSSHRKTKKPLPPT----------------------------------------- Btk29A_Dmel -SNGSSPAQNSTRSISPNSSTTNSQFSLQHNSSGSLGGGVGGGLGGGGSLGLGGGGGGGG TEC_Mmus ---------SSIRKTLPPA----------------------------------------- TXK_Mmus ---------PSKRKPL-------------------------------------------- TEC_Spur -----QHTDNGIRPPVPPT----------------------------------------- AqueK442_Aque ------------------------------------------------------------ AqueK443_Aque ------------------------------------------------------------ AqueK444_Aque ------------------------------------------------------------ AqueK445_Aque ------------------------------------------------------------ AqueK446_Aque ------------------------------------------------------------ AqueK447_Aque PTKEY-APEPGKKKSFKKV----------------------------------------- AqueK448_Aque PTR---GSGNIQHKALPPI----------------------------------------- TXK_Hsap ------------------------------------------------------------ TEC_Hsap --------PETK------------------------------------------------ ITK_Hsap --------PEDN------------------------------------------------ ITK_Mmus --------PEDN------------------------------------------------ BTK_Mmus --------PEED------------------------------------------------ BMX_Mmus --------PE-------------------------------------------------- BMX_Hsap --------PD-------------------------------------------------- BTK_Hsap --------PEED------------------------------------------------ Btk29A_Dmel SCTPTSLQPQSS------------------------------------------------ TEC_Mmus --------PEIK------------------------------------------------ TXK_Mmus ------------------------------------------------------------ TEC_Spur --------PVPT------------------------------------------------ AqueK442_Aque ------------------------------------------------------------ AqueK443_Aque ------------------------------------------------------------ AqueK444_Aque ------------------------------------------------------------ AqueK445_Aque ------------------------------------------------------------ AqueK446_Aque ------------------------------------------------------------ AqueK447_Aque --------PEWERRSNYLK----------------------------------------- AqueK448_Aque --------PPDAGG---FNGSGPGYGGQGYGGQGYGGQGYGGQGYGGQGYGGQGYGGGGH TXK_Hsap ------------------------------------------------------------ TEC_Hsap ------------------------------------------------------------ ITK_Hsap ------------------------------------------------------------ ITK_Mmus ------------------------------------------------------------ BTK_Mmus ------------------------------------------------------------ BMX_Mmus ------------------------------------------------------------ BMX_Hsap ------------------------------------------------------------ BTK_Hsap ------------------------------------------------------------ Btk29A_Dmel --------------------------------------------------------LTTF TEC_Mmus ------------------------------------------------------------ TXK_Mmus ------------------------------------------------------------ TEC_Spur -----------------------P--------------------------------N--- AqueK442_Aque ------------------------------------------------------------ AqueK443_Aque ------------------------------------------------------------ AqueK444_Aque ------------------------------------------------------------ AqueK445_Aque ------------------------------------------------------------ AqueK446_Aque ------------------------------------------------------------ AqueK447_Aque ---------------------------------------------------NLPKEN--- AqueK448_Aque NVHGPGPMASGPVYPASSGGGGGIYPHQPMAHANSGHVVVSNTHIQSGGHRTAPYQD--- TXK_Hsap ----------------------------PPLPPSEV--AEEK------------------ TEC_Hsap -----------------------KRRPPPPIPLEEE--DNSE------------------ ITK_Hsap -----------------------RRP-------LW---EPEE------------------ ITK_Mmus -----------------------RRS-------FQ---EPEE------------------ BTK_Mmus -----------------Q----ILKKPLPPEPTAAPISTTEL------------------ BMX_Mmus -----------------R----LLKIPR-AVPVLK-MDASSS------------------ BMX_Hsap -----------------R----VLKIPR-AVPVLK-MDAPSSSTTLAQYDNESKKNYGSQ BTK_Hsap -----------------Q----ILKKPLPPEPAAAPVSTSEL------------------ Btk29A_Dmel KQSPTLLNGNGTLLDANM----PGGIPTPGTPNSKAKDNSHF------------------ TEC_Mmus -----------------------KRRPPPPIPPEE---ENTE------------------ TXK_Mmus ----------------------------PPLPQEPP---DER------------------ TEC_Spur -----------------P----TPRPPKPPIPNPPV-TDRPK------------------ AqueK442_Aque ------------------------------------------------------------ AqueK443_Aque ------------------------------------------------------------ AqueK444_Aque ------------------------------------------------------------ AqueK445_Aque ------------------------------------------------------------ AqueK446_Aque ------------------------------------------------------------ AqueK447_Aque -----------------ELLFLAK-RCLSDLPTGRPELVDSC------------------ AqueK448_Aque -----------------H----NL-APPPPVSKTRPSSTKPS------------------ TXK_Hsap ----I---QVKAL----------------------------------------------- TEC_Hsap ----E---IVVAM----------------------------------------------- ITK_Hsap ----T---VVIAL----------------------------------------------- ITK_Mmus ----T---LVIAL----------------------------------------------- BTK_Mmus ----K---KVVAL----------------------------------------------- BMX_Mmus ----G---AILPQ----------------------------------------------- BMX_Hsap PPSSS---TSLAQ----------------------------------------------- BTK_Hsap ----K---KVVAL----------------------------------------------- Btk29A_Dmel ---VK---LVVAL----------------------------------------------- TEC_Mmus ----E---IVVAM----------------------------------------------- TXK_Mmus ----I---QVKAL----------------------------------------------- TEC_Spur ----M---IVIAK----------------------------------------------- AqueK442_Aque ------------------------------------------------------------ AqueK443_Aque ------------------------------------------------------------ AqueK444_Aque ------------------------------------------------------------ AqueK445_Aque ------------------------------------------------------------ AqueK446_Aque ------------------------------------------------------------ AqueK447_Aque ----HFVEQVLSKYPKMQNVMQLLKEKEAAEKHLCELNAENEALRAEKVEIEKQLRADCE AqueK448_Aque ----F---EVMAM----------------------------------------------- TXK_Hsap -------------------YDFLPREPCNLALRRAEEYLILEKYNPHWWKAR-------- TEC_Hsap -------------------YDFQAAEGHDLRLERGQEYLILEKNDVHWWRAR-------- ITK_Hsap -------------------YDYQTNDPQELALRRNEEYCLLDSSEIHWWRVQ-------- ITK_Mmus -------------------YDYQTNDPQELALRCDEEYYLLDSSEIHWWRVQ-------- BTK_Mmus -------------------YDYMPMNANDLQLRKGEEYFILEESNLPWWRAR-------- BMX_Mmus -------------------YDSYSKKSCGSQPTSNIRYIPR-EDCPDWWQVR-------- BMX_Hsap -------------------YDSNSKKIYGSQPNFNMQYIPR-EDFPDWWQVR-------- BTK_Hsap -------------------YDYMPMNANDLQLRKGDEYFILEESNLPWWRAR-------- Btk29A_Dmel -------------------YPFKAIEGGDLSLEKNAEYEVIDDSQEHWWKVK-------- TEC_Mmus -------------------YDFQATEAHDLRLERGQEYIILEKNDLHWWRAR-------- TXK_Mmus -------------------YDFLPREPGNLALKRAEEYLILERCDPHWWKAR-------- TEC_Spur -------------------YDYDPLETIDIPLKRGKEYSVLNNSRDYWWKVR-------- AqueK442_Aque ------------------------------------------------------------ AqueK443_Aque ------------------------------------------------------------ AqueK444_Aque ------------------------------------------------------------ AqueK445_Aque ------------------------------------------------------------ AqueK446_Aque ------------------------------------------------------------ AqueK447_Aque RLTAKVAGLQNTLSSKENEFNYCTQVLKEIIRSRDEQLVKLQEDNVELLKKREADLKEEH AqueK448_Aque -------------------YDYPGIEKGDLPLCKGQKVVIFDNSRDHWWRAR-------- TXK_Hsap ------------------------------------------------------------ TEC_Hsap ------------------------------------------------------------ ITK_Hsap ------------------------------------------------------------ ITK_Mmus ------------------------------------------------------------ BTK_Mmus ------------------------------------------------------------ BMX_Mmus ------------------------------------------------------------ BMX_Hsap ------------------------------------------------------------ BTK_Hsap ------------------------------------------------------------ Btk29A_Dmel ------------------------------------------------------------ TEC_Mmus ------------------------------------------------------------ TXK_Mmus ------------------------------------------------------------ TEC_Spur ------------------------------------------------------------ AqueK442_Aque ------------------------------------------------------------ AqueK443_Aque ------------------------------------------------------------ AqueK444_Aque ------------------------------------------------------------ AqueK445_Aque ------------------------------------------------------------ AqueK446_Aque ------------------------------------------------------------ AqueK447_Aque LTELAAMEEYEAKLLAATTEHKQQLCESHRESEVKVSEVLKEPVKSSQALKDTTAQQQST AqueK448_Aque ------------------------------------------------------------ TXK_Hsap --DRLG---NEGLIPSNYV---------------------TENK--ITNLEIYEWYHRNI TEC_Hsap --DKYG---NEGYIPSNYV---------------------TGKK--SNNLDQYEWYCRNM ITK_Hsap --DRNG---HEGYVPSSYL---------------------VEKS--PNNLETYEWYNKSI ITK_Mmus --DKNG---HEGYAPSSYL---------------------VEKS--PNNLETYEWYNKSI BTK_Mmus --DKNG---QEGYIPSNYI---------------------TE-A--EDSIEMYEWYSKHM BMX_Mmus --KLKS---EEDIACSNQLERNIASHSTSKMSWGFPESSSSE-E--EENLHAYDWFAGNI BMX_Hsap --KLKSSSSSEDVASSNQKERNV-NHTTSKISWEFPESSSSE-E--EENLDDYDWFAGNI BTK_Hsap --DKNG---QEGYIPSNYV---------------------TE-A--EDSIEMYEWYSKHM Btk29A_Dmel --DALG---NVGYIPSNYV---------------------KPKA--LLGLERYEWYVGDM TEC_Mmus --DKYG---SEGYIPSNYV---------------------TGKK--SNNLDQYGWYCRNT TXK_Mmus --DRFG---NEGLIPSNYV---------------------TENR--LANLEIYEWYHKNI TEC_Spur --DRHG---REGFIPSNYV---------------------EEKSKYSTGLERYDWFNGTW AqueK442_Aque ------------------------------------------------------------ AqueK443_Aque ------------------------------------------------------------ AqueK444_Aque ------------------------------------------------------------ AqueK445_Aque ------------------------------------------------------------ AqueK446_Aque ------------------------------------------------------------ AqueK447_Aque PMAIDG---KEGLVASNIV---------------------K-----KVGLESEDWFFPTL AqueK448_Aque --DDRG---NEGFVPSNYV---------------------K-----KVGLESEDWFFPTL TXK_Hsap TRNQAEHLLRQESKEGAFIVRDSRHLGSYTISVFMGARR-STEAAIKHYQIKKN--DSGQ TEC_Hsap NRSKAEQLLRSEDKEGGFMVRDSSQPGLYTVSLYTKFGG-EGSSGFRHYHIKETTTSPKK ITK_Hsap SRDKAEKLLLDTGKEGAFMVRDSRTAGTYTVSVFTKAVVSENNPCIKHYHIKETNDNPKR ITK_Mmus SRDKAEKLLLDTGKEGAFMVRDSRTPGTYTVSVFTKAII-SENPCIKHYHIKETNDSPKR BTK_Mmus TRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTG-EPQGVIRHYVVCST--PQSQ BMX_Mmus SRSQSEQLLRQKGKEGAFMVRNSSQMGMYTVSLFSKAVN-DKKGTVKHYHVHTN--AENK BMX_Hsap SRSQSEQLLRQKGKEGAFMVRNSSQVGMYTVSLFSKAVN-DKKGTVKHYHVHTN--AENK BTK_Hsap TRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTG-DPQGVIRHYVVCST--PQSQ Btk29A_Dmel SRQRAESLLKQGDKEGCFVVRKSSTKGLYTLSLHTKV----PQSHVKHYHIKQN--ARCE TEC_Mmus NRSKAEQLLRTEDKEGGFMVRDSSQPGLYTVSLYTKFGG-EGSSGFRHYHIKETATSPKK TXK_Mmus TRNQTERLLRQEAKEGAFIVRDSRHLGSYTISVFTRARR-HTQSSIKHYQIKKN--DSGQ TEC_Spur SRQRTELELKQESKEGCFTVRNSRTPGLCTLSVLAKEKGPSGEDVVRHYHIKQN--SIKE AqueK442_Aque --------------------------------------------QAMHYLIRID--EEKK AqueK443_Aque -----------------------------------------------HYHIKND--EEKK AqueK444_Aque -----------------------------------------------HYHIKND--EEKK AqueK445_Aque --------------------------------------------SVLQILM--------- AqueK446_Aque ------------------------------------------------------------ AqueK447_Aque SRVEAEAILKQENKDGTFVVRNSSQE-NYAISVFSQ------NGNVYHYPIKND--KEKK AqueK448_Aque SRARAENILKQENKEGAFVVRNSSRDNMYTLSICH-------EGQVRHYHIKDD--EEKK TXK_Hsap WYVAERHAFQSIPELIWYHQHNAAGLMTRLRYPVGLMGSCLPAT--AGFSYEKWEIDPSE TEC_Hsap YYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTT--AGFSYEKWEINPSE ITK_Hsap YYVAEKYVFDSIPLLINYHQHNGGGLVTRLRYPVCFGRQKAPVT--AGLRYGKWVIDPSE ITK_Mmus YYVAEKYVFDSIPLLIQYHQYNGGGLVTRLRYPVCSWRQKAPVT--AGLRYGKWVIQPSE BTK_Mmus YYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSKQNKNAPST--AGLGYGSWEIDPKD BMX_Mmus LYLAENYCFDSIPKLIHYHQHNSAGMITRLRHPVSTKANKVPVS--VALGSGIWELKREE BMX_Hsap LYLAENYCFDSIPKLIHYHQHNSAGMITRLRHPVSTKANKVPDS--VSLGNGIWELKREE BTK_Hsap YYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPST--AGLGYGSWEIDPKD Btk29A_Dmel YYLSEKHCCETIPDLINYHRHNSGGLACRLKSSPC--DRPVPPT--AGLSHDKWEIHPME TEC_Mmus YYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSTKGKNAPTT--AGFSYDKWEINPSE TXK_Mmus WYITERHLFPSVPELIQYHQYNAAGLISRLRYPIGLLGSCLPAT--SGFSYEKWEIDPSE TEC_Spur FYVAEKHCFRDMGKLVEYHQHNAGGLITRLRNPPGF---TLPTT--AGLGSTKWEINRSE AqueK442_Aque YYIYNMHRFPTVTELIEYHKLNGGGLPTRLRQPPALLVPNQPALRVSSAFDDKWRIDKSE AqueK443_Aque YFISERHRFPTIIELIDYHKLNGGGLATRLKRPPALLVPDQPVL--SSAFDDKWQIDKSE AqueK444_Aque YFVSEKHRFPTITELIEYYKLNGGGLDTRLKRPPTLLAPDQPVL--SSAFDYKWQIDKSE AqueK445_Aque ------------------------------------KTSDQ-----LFLSNDKWRIDKSE AqueK446_Aque ------------------------------------------------------------ AqueK447_Aque YFVSEKHRFPTVIKLIEYYKLNGGGLVTRLKRLPALLVSNQPVL--SSAFDYKWQIDKTE AqueK448_Aque YFISEKHRFPTITELIEYHKLNGGGLVTRLRRPPTQLVPNQPVL--SSAFDTKWQIDKSE TXK_Hsap LAFIKEIGSGQFGVVHLGEWR-SHIQVAIKAINEGSMSEEDFIEEAKVMMKLSHSKLVQL TEC_Hsap LTFMRELGSGLFGVVRLGKWR-AQYKVAIKAIREGAMCEEDFIEEAKVMMKLTHPKLVQL ITK_Hsap LTFVQEIGSGQFGLVHLGYWL-NKDKVAIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQL ITK_Mmus LTFVQEIGSGQFGLVHLGYWL-NKDKVAIKTIQEGAMSEEDFIEEAEVMMKLSHPKLVQL BTK_Mmus LTFLKELGTGQFGVVKYGKWR-GQYDVAIKMIREGSMSEDEFIEEAKVMMNLSHEKLVQL BMX_Mmus ITLLKELGNGQFGVVQLGQWK-GQYDVAVKMIKEGAMSEDEFFQEAQTMMKLSHPKLVKF BMX_Hsap ITLLKELGSGQFGVVQLGKWK-GQYDVAVKMIKEGSMSEDEFFQEAQTMMKLSHPKLVKF BTK_Hsap LTFLKELGTGQFGVVKYGKWR-GQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQL Btk29A_Dmel LMLMEELGSGQFGVVRRGKWR-GSIDTAVKMMKEGTMSEDDFIEEAKVMTKLQHPNLVQL TEC_Mmus LTFMRELGSGLFGVVRLGKWR-AQYKVAIKAIREGAMCEEDFIEEAKVMMKLTHPKLVQL TXK_Mmus LAFVKEIGSGQFGVVHLGEWR-AHIPVAIKAINEGSMSEEDFIEEAKVMMKLSHSRLVQL TEC_Spur LKILQELGRGQFGIVHLAKLTHNNRFVAVKRMQEGSMSEEDFIDEAKVMKELQHENLVQL AqueK442_Aque LSLGKELGSGQFKRVVAGQWR-NEVDVAIK-IMEGALNEDDLIKEAILMQKFQHDNLVKL AqueK443_Aque LSLGDELSSGEFKRVVIGQWC-NKVDVAIKMIKEDAMNEDDFIEEAILMMKFQHDNLVKL AqueK444_Aque LSFGKELGSGEFKRVVAGQWR-NKVDVAIKMIKEDVMNEDDFIEEAILMLKFQHDNLVKL AqueK445_Aque LSLGKELGSGEFKKVVAGQWR-NEVDVAIK-IMEGALNEDDLIKEATLMEKFQHDNLVKL AqueK446_Aque ------------------------------MIKEDAMNEDDFIEEAILMIKFQHDNLVKL AqueK447_Aque LSFGKELGSGEFKRVVAGQWR-NKGDIAIKMIKEDTMNEEHLIEEAILMLKFQHDNLVKL AqueK448_Aque LSLGKELGSGQFGRVVAGQWR-NKVDVAIKMMKEGAMNEDDFIEEAKVMQKFQHDNLVKL : *. : *:.::.** * :: * .**:: TXK_Hsap YGVCIQRKPLYIVTEFMENGCLLNYLRENKGK-LR-KEMLLSVCQDICEGMEYLERNGYI TEC_Hsap YGVCTQQKPIYIVTEFMERGCLLNFLRQRQGH-FS-RDVLLSMCQDVCEGMEYLERNSFI ITK_Hsap YGVCLEQAPICLVFEFMEHGCLSDYLRTQRGL-FA-AETLLGMCLDVCEGMAYLEEACVI ITK_Mmus YGVCLEQAPICLVFEFMEHGCLSDYLRSQRGL-FA-AETLLGMCLDVCEGMAYLEKACVI BTK_Mmus YGVCTKQRPIFIITEYMANGCLLNYLREMRHR-FQ-TQQLLEMCKDVCEAMEYLESKQFL BMX_Mmus YGVCSKKYPIYIVTEYITNGCLLNYLKSHGKG-LE-SCQLLEMCYDVCEGMAFLESHQFI BMX_Hsap YGVCSKEYPIYIVTEYISNGCLLNYLRSHGKG-LE-PSQLLEMCYDVCEGMAFLESHQFI BTK_Hsap YGVCTKQRPIFIITEYMANGCLLNYLREMRHR-FQ-TQQLLEMCKDVCEAMEYLESKQFL Btk29A_Dmel YGVCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMGLLLDMCIQVSKGMTYLERHNYI TEC_Mmus YGVCTQQKPIYIVTEFMERGCLLNFLRQRQGH-FS-RDMLLSMCQDVCEGMEYLERNSFI TXK_Mmus YGVCIQQKPLYIVTEFMENGCLLDYLRERKGQ-LQ-KALLLSMCQDICEGMAYLERSCYI TEC_Spur YGVTSAQRPMCIVTEYMSKGCLLSYLRTHKFMLLENTAILIYMTQQVCFGMAYLESKGFI AqueK442_Aque CGVCIRQRSVYIITELMVNGSLLQYLCNNQRL-VNKTDILLDMAIQICATMKFLEQSGFI AqueK443_Aque YGVCIRQGPVYIITELMVNGSLLQYLRKNKHL-VDKTDIILDMALQICAAMKFFEQSGFI AqueK444_Aque YGVCIRQGPVYIITELMANGCLLQYIRNNQHL-VKKTGIILDMAIQISDGMKFFEQSGLI AqueK445_Aque YGVCIGQGPVYIITELNGNGSLLQYLCNNQHL-VNKTDILLDMAIQICAAMKFLEQSGFI AqueK446_Aque YGVCIRQGPVYIITELMANGSLLQYLRNNQHL-VDNTDIILDMAIQICAAMKFFEQSGFI AqueK447_Aque YGVCIGQGPVYIITELMANGCLLQYLRNNQHL-VKKTDIMLDMAIQICDAMKFFEQSGFI AqueK448_Aque YGVCIKQGAVYIITELMVNGCLLQYLRNNKHL-VEKTDIILDMAIQICAAMKFLEQSGFI ** . .: :: * .*.* .:: . :: : ::. * ::* : TXK_Hsap HRDL-----------------------------AARNCLVSSTCIVKISDFGMTRYVLDD TEC_Hsap HRDL-----------------------------AARNCLVSEAGVVKVSDFGMARYVLDD ITK_Hsap HRDL-----------------------------AARNCLVGENQVIKVSDFGMTRFVLDD ITK_Mmus HRDL-----------------------------AARNCLVGENQVIKVSDFGMTRFVLDD BTK_Mmus HRDL-----------------------------AARNCLVNDQGVVKVSDFGLSRYVLDD BMX_Mmus HRDL-----------------------------AARNCLVDSDLSVKVSDFGMTRYVLDD BMX_Hsap HRDL-----------------------------AARNCLVDRDLCVKVSDFGMTRYVLDD BTK_Hsap HRDL-----------------------------AARNCLVNDQGVVKVSDFGLSRYVLDD Btk29A_Dmel HRDL-----------------------------AARNCLVGSENVVKVADFGLARYVLDD TEC_Mmus HRDL-----------------------------AARNCLVNEAGVVKVSDFGMARYVLDD TXK_Mmus HRDL-----------------------------AARNCLVSSACVVKISDFGMARYVLDD TEC_Spur HRDL-----------------------------AARNCLVGDKHIVKVADFGLTRYVMDD AqueK442_Aque HRNL-----------------------------PARNCQVGYSNIVKVGGFSSARFVPDD AqueK443_Aque HRNL-----------------------------AAINCLVGDRNIVKVGGFSSARFVPDD AqueK444_Aque HRDLYMEQISNLKHKIKVTTKVAKKFQLVMINMAARNCLVGDRNIVKVGGFSLARFVPDD AqueK445_Aque HRNL-----------------------------AARNCLVGDRNIVKVGSFSSARFVPDD AqueK446_Aque HRNL-----------------------------AARNCLVGDRNIVKVAGFGSARYVPDN AqueK447_Aque HRDL-----------------------------AARNCLVGYSNIVKVGGFSLARFVPDD AqueK448_Aque HRDL-----------------------------AARNCLVGDRNIVKVGDFGLARFVTDD **:* .* ** *. :*:..*. :*:* *: TXK_Hsap EYVSSFGAKFPIKWSPPEVFLFNKYSSKSDVWSFGVLMWEVFT---EGKMPFENKSNLQV TEC_Hsap QYTSSSGAKFPVKWCPPEVFNYSRFSSKSDVWSFGVLMWEVFT---EGRMPFEKYTNYEV ITK_Hsap QYTSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFS---EGKIPYENRSNSEV ITK_Mmus QYTSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFS---EGKIPYENRSNSEV BTK_Mmus EYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYS---LGKMPYERFTNSET BMX_Mmus QYVSSVGTKFPVKWSAPEVFHYFKYSSKSDVWAFGILMWEVFS---LGKQPYDLYDNSEV BMX_Hsap QYVSSVGTKFPVKWSAPEVFHYFKYSSKSDVWAFGILMWEVFS---LGKQPYDLYDNSQV BTK_Hsap EYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYS---LGKMPYERFTNSET Btk29A_Dmel QYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFT---CGKMPYGRLKNTEV TEC_Mmus QYTSSSGAKFPVKWCPPEVFNYSRFSSKSDVWSFGVLMWEIFT---EGRMPFEKNTNYEV TXK_Mmus EYISSSGAKFPVKWCPPEVFHFNKYSSKSDVWSFGVLMWEVFT---EGKMPFENKSNLQV TEC_Spur EYTSS-GTKFPIKWAPPEVLHYTRFSSKSDVWAFGILMWEVFS---GGLAPYPAMSNVEV AqueK442_Aque EYEASVGVKYAVRWSPPEVITHARYSS--------------------------------- AqueK443_Aque EYTASEGAEFPARWSAPEVITHARYSSKSDIWSYGILLWELWT---GGKIPYPAFTTPEI AqueK444_Aque EYTASVGAKYAVKWSPPEVITHARFSSKSDIWSYGILLWELWS---GGKTPYPAFTNPQA AqueK445_Aque EYKASVGAKYAVRWSAPEVITHARFSSKSDIWSYD-LEWKIVGLRSQKETPFVVFGC--- AqueK446_Aque EYTASEGTEFAVKWIAPEVITHARYSSKSDVWSYGILLWELWT---GGKTPYPAFTNPQV AqueK447_Aque QYTASEGAKYAVKWSPPEVITHGRFSSKSDVWSYGILLWELWS---SGKNPYLGISNPLV AqueK448_Aque EYTASEGTKFPIKWAAPEVITHARFSSKSDVWSYGILLWELWS---GGKTPYPAFTNPQV :* :* * ::. :* .***: . ::** TXK_Hsap VEAISE-GFRLYRPHLAPMSIYEVMYSCWHEKP--------------------------- TEC_Hsap VTMVTR-GHRLYQPKLASNYVYEVMLRCWQEKP--------------------------- ITK_Hsap VEDIST-GFRLYKPRLASTHVYQIMNHCWKERP--------------------------- ITK_Mmus VEDIST-GFRLYKPRLASCHVYQIMNHCWKEKP--------------------------- BTK_Mmus AEHIAQ-GLRLYRPHLASERVYTIMYSCWHEKA--------------------------- BMX_Mmus VVKVSQ-GHRLYRPQLASDTIYQIMYSCWHELP--------------------------- BMX_Hsap VLKVSQ-GHRLYRPHLASDTIYQIMYSCWHELP--------------------------- BTK_Hsap AEHIAQ-GLRLYRPHLASEKVYTIMYSCWHEKA--------------------------- Btk29A_Dmel VERVQR-GIILEKPKSCAKEIYDVMKLCWSHGP--------------------------- TEC_Mmus VTMVTR-GHRLHRPKLASKYLYEVMLRCWQERP--------------------------- TXK_Mmus VEAISQ-GFRLYRPHLAPMTIYRVMYSCWHESP--------------------------- TEC_Spur VDQVTRHNYRMERPDHCPYQMYRIMKDCWRECA--------------------------- AqueK442_Aque ------------------------------------------------------------ AqueK443_Aque LDGVLK-GYRLEKPKLCPSNIYDLMTRSWEKNP--------------------------- AqueK444_Aque LDEVSK-GYRLEKPKLCPSKVYDLMKRSWQKGLCYLHGKHPPIVHRDLTANNVLLTSSYS AqueK445_Aque ------------------------------------------------------------ AqueK446_Aque LDEVLR-GYRLEKPKLCPSKIYDLMKRSWQT----------------------------- AqueK447_Aque LDKVLS-GYRLEKPKLCPSKVYDLMKRSWQVNP--------------------------- AqueK448_Aque LDEVLR-GYRLENPKLCPPEVYDLMKKSWQANP--------------------------- TXK_Hsap -----------------------------------EG----RPTFAELLR---------- TEC_Hsap -----------------------------------EG----RPSFEDLLR---------- ITK_Hsap -----------------------------------ED----RPAFSRLLR---------- ITK_Mmus -----------------------------------ED----RPPFSQLLS---------- BTK_Mmus -----------------------------------DE----RPSFKILLS---------- BMX_Mmus -----------------------------------EK----RPTFQQLLS---------- BMX_Hsap -----------------------------------EK----RPTFQQLLS---------- BTK_Hsap -----------------------------------DE----RPTFKILLS---------- Btk29A_Dmel -----------------------------------EE----RPAFRVLMD---------- TEC_Mmus -----------------------------------EG----RPSFEDLLR---------- TXK_Mmus -----------------------------------KG----RPTFAELLQ---------- TEC_Spur -----------------------------------KVYNSNGPSLQCPVA---------- AqueK442_Aque ------------------------------------------------------------ AqueK443_Aque -----------------------------------FK----RPSFAVLLD---------- AqueK444_Aque AKISDLGVSRLADMFKKHHLTTAPGNAMVMPPEALKD----NPVYDHKYLVDQKWLKKWK AqueK445_Aque ------------------------------------------------------------ AqueK446_Aque ------------------------------------------------------------ AqueK447_Aque -----------------------------------SD----RPSFAVLLD---------- AqueK448_Aque -----------------------------------ED----RPSFAVLSD---------- TXK_Hsap ----------AVTEIAE-------------TW TEC_Hsap ----------TIDELVECE--------ETFGR ITK_Hsap ----------QLAEIAE------------SGL ITK_Mmus ----------QLAEIAE------------AGL BTK_Mmus ----------NILDVMD------------EES BMX_Mmus ----------AIEPLREQ-----------DKP BMX_Hsap ----------SIEPLREK-----------DKH BTK_Hsap ----------NILDVMD------------EES Btk29A_Dmel ----------QLALVAQT-----------LTD TEC_Mmus ----------TIDELVECE--------ETFGR TXK_Mmus ----------VLTEIAE-------------TW TEC_Spur ----------SLM--WECDLSPVPSHFIAMEM AqueK442_Aque -------------------------------K AqueK443_Aque ----------YLKAMVG-------DDYSDAID AqueK444_Aque KYTGFDSWDQATAEHAH--PGPIDTAILFKRM AqueK445_Aque ---------------------------DKTYL AqueK446_Aque -------------------------------V AqueK447_Aque ----------SLKAMVG-------GDYSDPVD AqueK448_Aque ----------SLKAMVG-------DDYSDAVD