CLUSTAL W (1.83) multiple sequence alignment TRKC_Hsap MDVSLC--------PAKCSFWRIFLLGSVWLDYVGSVLACPAN-CVCSKTEINCRRPDDG TRKB_Hsap MSSWIR-----WHGPAMARL---WGFCWLVVGFWRAAFACPTS-CKCSASRIWCSDPSPG TRKA_Hsap MLRGGRRGQLGWHSWAAGP---GSLLAWLILASAGAA-PCPDACCPHGSSGLRCTRDGAL D1073.1_Cele MILR-------------------ILLTLLILTYSPGVLTIS-QCVKATRDTVRCDDFI-- TRKA_Mmus MLRGQRLGQLGWHRPAAGL---GSLMTSLMLACASAA-SCREVCCPVGPSGLRCTRAGSL TRKB_Mmus MSPWLK-----WHGPAMARL---WGLCLLVLGFWRASLACPTS-CKCSSARIWCTEPSPG TRKC_Mmus MDVSLC--------PAKCSFWRIFLLGSVWLDYVGSVLACPAN-CVCSKTEINCRRPDDG Trk_Spur MFDL------------KRKLWRIFR---------QQELRTPP------------------ * TRKC_Hsap NL-FPLLEGQDSGNSNGNASINITDISRNITS-IHIENWRSLHTLNAVDMELYTGLQKLT TRKB_Hsap IVAFPRLEPNSV------------D-PENITE-IFIANQKRLEIINEDDVEAYVGLRNLT TRKA_Hsap DS-LHHL----P------------G-AENLTE-LYIENQQHLQHLELRDLRGLGELRNLT D1073.1_Cele -------------DFNG-----------TAK-VLVVGNCSSLQNI--DEMLGFGPFHSVT TRKA_Mmus DT-LRGL----R------------G-AGNLTE-LYVENQQHLQRLEFEDLQGLGELRSLT TRKB_Mmus IVAFPRLEPNSV------------D-PENITE-ILIANQKRLEIINEDDVEAYVGLRNLT TRKC_Mmus NL-FPLLEGQDSGNSNGNASINITDISRNITS-IHIENWRGLHTLNAVDMELYTGLQKLT Trk_Spur ---------------N------------AVAKLAIIRDQLSLSSIGLSDLTGFSELT--- : : * : :: : TRKC_Hsap IKNSGLR-SIQPRAFA-KNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCS-C TRKB_Hsap IVDSGLK-FVAHKAFL-KNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCS-C TRKA_Hsap IVKSGLR-FVAPDAFH-FTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCS-C D1073.1_Cele NVTFDCVVTHFPWEFANIFPNIRHIHINKCNLTSLPWQSIWTETLKTVDFSSCPIQCS-C TRKA_Mmus IVKSGLR-FVAPDAFR-FTPRLSHLNLSSNALESLSWKTVQGLSLQDLTLSGNPLHCS-C TRKB_Mmus IVDSGLK-FVAYKAFL-KNSNLRHINFTRNKLTSLSRRHFRHLDLSDLILTGNPFTCS-C TRKC_Mmus IKNSGLR-NIQPRAFA-KNPHLRYINLSSNRLTTLSWQLFQTLSLRELRLEQNFFNCS-C Trk_Spur -----------------------HLEITNTNLSYIHVHSFERLKLKTLLLADNPLVCSNC :.:. * : : . * : : : ** * TRKC_Hsap DIRWMQLWQEQGEAKLNSQNL-YCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGD TRKB_Hsap DIMWIKTLQEA-KSSPDTQDL-YCLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGK TRKA_Hsap ALRWLQRWEEEGLGGVPEQKL-QCHGQG----PLAHMPNASCGVPTLKVQVPNASVDVGD D1073.1_Cele QNQWMRAKEIF-EKITEPKSLRKCA--------------WNCDPGKMMF-PGVIYSKNGD TRKA_Mmus ALFWLQRWEQEGLCGVHTQTL-HDSGPGDQFLPLGH--NTSCGVPTVKIQMPNDSVEVGD TRKB_Mmus DIMWLKTLQET-KSSPDTQDL-YCLNESSKNMPLANLQIPNCGLPSARLAAPNLTVEEGK TRKC_Mmus DIRWMQLWQEQGEARLDSQSL-YCISADGSQLPLFRMNISQCDLPEISVSHVNLTVREGD Trk_Spur QNNWLREPHQDLTLG---TNL-TCVHNETKTL-MQSFVVDNCRVPSVNVTPKHLEIRDGE *:: . * .* . *. TRKC_Hsap NAVITCNGSGS------PLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNG TRKB_Hsap SITLSCSVAGD------PVPNMYWDVGNLVSKHMNET-----SHTQGSLRITNISSDDSG TRKA_Hsap DVLLRCQVEGR------GLEQAGWILTELEQSATV---MKSGGLPSLGLTLANVTSDLNR D1073.1_Cele NVTVHVGFDDQVLNRTIDKPYFDWAFSKHPHKHEEII-----AEKGADLMITNLKREDMG TRKA_Mmus DVFLQCQVEGL------ALQQADWILTELEGAATV---KKFGDLPSLGLILVNVTSDLNK TRKB_Mmus SVTLSCSVGGD------PLPTLYWDVGNLVSKHMNET-----SHTQGSLRITNISSDDSG TRKC_Mmus NAVITCNGSGS------PLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNG Trk_Spur SFNASCEVDGE------PHPSLRWDVSRLVSPYQL---VNVS-KRQQIIMVQNASYKDTG . . * . : : * . . TRKC_Hsap -FTLTCIA--ENVVGMSNASVALTVYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWL TRKB_Hsap -KQISCVA--ENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWF TRKA_Hsap -KNVTCWA--ENDVGRAEVSVQVNVSFPASV-QLHTAVEMHHWCIPFSVDGQPAPSLRWL D1073.1_Cele VIGVKCWHCLDFLVGK----IELRANYPVKVAFVDKTRLDTDF---LVVTGYPIDNISMA TRKA_Mmus -KNVTCWA--ENDVGRAEVSVQVSVSFPASV-HLGLAVEQHHWCIPFSVDGQPAPSLRWL TRKB_Mmus -KQISCVA--ENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVRGNPKPALQWF TRKC_Mmus -FTLTCIA--ENVVGMSNASVALTVYYPPRVVSLVEPEVRLEHCIEFVVRGNPTPTLHWL Trk_Spur --LLECIV--SSVAGWRAAEVNLTVKVAPKINRFWGPIKRFHYCIDLNVTALPTPNVTIY : * . .* : : . . : . . . : * . * : TRKC_Hsap HNGQP--LRESKIIH-------------------------VE-YY---QEG-EISEGCLL TRKB_Hsap YNGAI--LNESKYIC-------------------------TK-IH---VTNHTEYHGCLQ TRKA_Hsap FNGSV--LNETSFIF-------------------------TE-FLEPA-ANETVRHGCLR D1073.1_Cele ITKMQSNYSETNFVGREKDAIFFSSLVVRMEKRPLFYQKTYRVFTKDAAE-GDHLSGDLR TRKA_Mmus FNGSV--LNETSFIF-------------------------TQ-FLESALTNETMRHGCLR TRKB_Mmus YNGAI--LNESKYIC-------------------------TK-IH---VTNHTEYHGCLQ TRKC_Mmus YNGQP--LRESKIIH-------------------------MD-YY---QEG-EVSEGCLL Trk_Spur HNGTK--ELHYDARLD----------NVTINSHPTM--RRYE-VTTKAR-TPWQIFGCLM . . . * * TRKC_Hsap FNKPTHYNNGNYTLIAKN--PLGTANQTINGHFLKEPFPES------------------- TRKB_Hsap LDNPTHMNNGDYTLIAKN--EYGKDEKQISAHFMGWPGIDDGANPNYPDVI-YEDYGTAA TRKA_Hsap LNQPTHVNNGNYTLLAAN--PFGQASASIMAAFMDNPFE---FNPEDPIPVSFSPVDT-N D1073.1_Cele FEVCT---NGSCDAIEKHVSHLGLINGTIDDFI-IVEYPY-------------------- TRKA_Mmus LNQPTHVNNGNYTLLAAN--PYGQAAASVMAAFMDNPFE---FNPEDPIPVSFSPVDG-N TRKB_Mmus LDNPTHMNNGDYTLMAKN--EYGKDERQISAHFMGRPGVDYETNPNYPEVL-YEDWT-TP TRKC_Mmus FNKPTHYNNGNYTLIAKN--ALGTANQTINGHFLKEPFPES------------------- Trk_Spur FLLPSHYDNGNYTLVVSN--ELGSDRKNISAIFFDGNV----AIPDYPETGSPSSQDN-R : : **. : : * : : TRKC_Hsap TDNFILFDEVSPTPPITVTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINKYGR---RS TRKB_Hsap NDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVM-LFLLKLAR---HS TRKA_Hsap ------------STSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGR---RN D1073.1_Cele -------------------------KQEIQIVVFL-IV--ICLLIV-VSALAFYHRLKLQ TRKA_Mmus ------------STSRDPVEKKDETPFGVSVAVGLAVSAALFLSALLLVLNKCGQ---RS TRKB_Mmus TDIGDTTNKSNEIPSTDVADQSNREHLSVYAVVVIASVVGFCLLVM-LLLLKLAR---HS TRKC_Mmus TDFFDFESDASPTPPITVTHKPEEDTFGVSIAVGLAAFACVLLVVLFIMINKYGR---RS Trk_Spur ------------TRTINPPMSRG-TP--SYVYILAAVGAGILLIVLVLFGRKYYTKK-RE : . * : : . TRKC_Hsap KFGMK---------------------------GPVAVISGEEDSASPLHHINHGITTPSS TRKB_Hsap KFGMKD-FSWFGFGKVKSRQGV----------GPASVISNDDDSASPLHHISNGSNTPSS TRKA_Hsap KFGIN---------------------------RP-AVLAPEDGLAMSLHFMTLGGSSLSP D1073.1_Cele SFLRE------------------------------KILSFRKRISLAQELQTRRA----- TRKA_Mmus KFGIN---------------------------RP-AVLAPEDGLAMSLHFMTLGGSSLSP TRKB_Mmus KFGMKADVSWFGIGKVKSRQGVGKLSMFLPPPGPASVISNDDDSASPLHHISNGSNTPSS TRKC_Mmus KFGMK---------------------------GPVAVISGEEDSASPLHHINHGITTPSS Trk_Spur RFRN-----------------------------------LGDGSATPFTSVA---CVLDA * . : . TRKC_Hsap LDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVF TRKB_Hsap SEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVF TRKA_Hsap TEGKGS-GLQ----GHIIENPQYFS--------DACVHHIKRRDIVLKWELGEGAFGKVF D1073.1_Cele SQETEETL-LRLE-----ERSSLAS-----DYTNMTLPFIDMGNIEIHEMLGKGHFGEVY TRKA_Mmus TEGKGS-GLQ----GHIMENPQYFS--------DTCVHHIKRQDIILKWELGEGAFGKVF TRKB_Mmus SEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVF TRKC_Mmus LDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVF Trk_Spur KR-GEDRVDL----VHMIPNPNYLARTDR-RSGSTAINHISRENIRFIGELGEGAFGVVC . ... . : .*. :* : **:* ** * TRKC_Hsap LAECYNLSPTKDKMLVAVKALKDPTL-AARKDFQREAELLTNLQHEHIVKFYGVCGDGDP TRKB_Hsap LAECYNLCPEQDKILVAVKTLKDASD-NARKDFHREAELLTNLQHEHIVKFYGVCVEGDP TRKA_Hsap LAECHNLLPEQDKMLVAVKALKEASE-SARQDFQREAELLTMLQHQHIVRFFGVCTEGRP D1073.1_Cele LASWDYTGP----RSVAVKSIRRVDM-AT----EKEARVLQDLEHPNIVKLYGMTRNNFN TRKA_Mmus LAECYNLLNDQDKMLVAVKALKEASE-NARQDFQREAELLTMLQHQHIVRFFGVCTEGGP TRKB_Mmus LAECYNLCPEQDKILVAVKTLKDASD-NARKDFHREAELLTNLQHEHIVKFYGVCVEGDP TRKC_Mmus LAECYNLSPTKDKMLVAVKALKDPTL-AARKDFQREAELLTNLQHEHIVKFYGVCGDGDP Trk_Spur LGQCEHLPGADGPTMVAIKTLKDASVGDARTDFEREAELLTNLQHKNIVAFYGVCTDHEP *.. **:*::: : .:**.:* *:* :** ::*: : TRKC_Hsap LIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLAS TRKB_Hsap LIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNP---PTELTQSQMLHIAQQIAAGMVYLAS TRKA_Hsap LLMVFEYMRHGDLNRFLRSHGPDAKLLAGGED-VAPGPLGLGQLLAVASQVAAGMVYLAG D1073.1_Cele LLLVFEHMNHGDLKTYLEQRAPVKSVYLQY-----PPPLVIDELKWIIKEITTGLVYLVE TRKA_Mmus LLMVFEYMRHGDLNRFLRSHGPDAKLLAGGED-VAPGPLGLGQLLAVASQVAAGMVYLAS TRKB_Mmus LIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNP---PTELTQSQMLHIAQQIAAGMVYLAS TRKC_Mmus LIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLAS Trk_Spur FFMVFEYMENGDLNNYLKSRGPDADCFTRNQA---LLPLTVKELLYIAKQIASGMVYMAS :::***:*.:***: :*. :.* * :: : .::::*:**:. TRKC_Hsap QHFVHRDLATRNCLVGA-----------NLLVKIGDFGMSRDVYS-TDYYRLFNPSGNDF TRKB_Hsap QHFVHRDLATRNCLVGE-----------NLLVKIGDFGMSRDVYS-TDYYR--------- TRKA_Hsap LHFVHRDLATRNCLVGQ-----------GLVVKIGDFGMSRDIYS-TDYYR--------- D1073.1_Cele QSIVHRDLAARNCLVAGDSDLKATSHFERPPIRISDFGMSRRLYDHSEYYT--------- TRKA_Mmus LHFVHRDLATRNCLVGQ-----------GLVVKIGDFGMSRDIYS-TDYYR--------- TRKB_Mmus QHFVHRDLATRNCLVGE-----------NLLVKIGDFGMSRDVYS-TDYYR--------- TRKC_Mmus QHFVHRDLATRNCLVGA-----------NLLVKIGDFGMSRDVYS-TDYYRLFNPSGNDF Trk_Spur QHFVHRDMATRNCLVGD-----------RLIVKIADFGMSRDVYS-TDYYR--------- :****:*:*****. ::*.****** :*. ::** TRKC_Hsap CIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVI TRKB_Hsap -----VGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVI TRKA_Hsap -----VGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAI D1073.1_Cele -----MDHRGALPVRWLPPEAVQSHKFTYNSDIWSLGVTMWECMSYGRQPFDGLSNLEVS TRKA_Mmus -----VGGRTMLPIRWMPPESILYRKFSTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAI TRKB_Mmus -----VGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVI TRKC_Mmus CIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVI Trk_Spur -----VGGHTMLPVRWMPPESIIYRTYSVESDVWSYGVVLWEIFEYGKQPWFGLSNHEVI :. : **:**:***:: :.:: :**:** ** :** : **:**: *** *. TRKC_Hsap ECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYK------------------ TRKB_Hsap ECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHT------------------ TRKA_Hsap DCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHA------------------ D1073.1_Cele SFTLAGMRPLKPERCPQDMYDLMVKCWHMEPVKRITAKQILEDELFDKIREGLPYRAANE TRKA_Mmus ECITQGRELERPRACPPDVYAIMRGCWQREPQQRLSMKDVHA------------------ TRKB_Mmus ECITQGRVLQRPRTCPQEVYELMLGCWQREPHTRKNIKSIHT------------------ TRKC_Mmus ECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYK------------------ Trk_Spur EYIHNGILLDCPKGCPKEVYKIMLGSWQRQPTQRMLIKDLHD------------------ . * *. ** ::* :* .*: :* * * : TRKC_Hsap ------------------------------------------------------------ TRKB_Hsap ------------------------------------------------------------ TRKA_Hsap ------------------------------------------------------------ D1073.1_Cele ANSLVSSCMLNINRYKDVVAETSFTTDPLNSSEIEVNDVPTENGKVNGQTVEKAEYEKSE TRKA_Mmus ------------------------------------------------------------ TRKB_Mmus ------------------------------------------------------------ TRKC_Mmus ------------------------------------------------------------ Trk_Spur ------------------------------------------------------------ TRKC_Hsap --------ILHALGKATPIYLD-IL-----G TRKB_Hsap --------LLQNLAKASPVYLD-IL-----G TRKA_Hsap --------RLQALAQAPPVYLD-VL-----G D1073.1_Cele SESDSGAVTFHGECSEDPLLCDRSI-----G TRKA_Mmus --------RLQALAQAPPSYLD-VL-----G TRKB_Mmus --------LLQNLAKASPVYLD-IL-----G TRKC_Mmus --------ILHALGKATPIYLD-IL-----G Trk_Spur --------AISQLSDENTPMVD-IVGRNTLV : . . * :