CLUSTAL W (1.83) multiple sequence alignment PIK3R4_Hsap MGNQLA--GIAPSQ-ILSVESYFSD-I-HD--FEYDKSLG-STRFFKVARA-KHR--EG- PIK3R4_Mmus MGNQLA--GIAPSQ-ILSVESYFSD-I-HD--FEYDKSLG-STRFFKVARA-KHR--EG- CG9746_Dmel MGNQLV--GIAPSQ-IYAVEHYFSGQFGSE--IAFSSNMG-STRFFKVAKA-KTD--EG- ZK930.1_Cele MGNINSLFTTNPSE-ILPVEVYLND-LS--CD--AVENLG-STRFMKVARG-RTH--EG- VPS15_Scer MGAQLS--LVVQASPSIAIFSYIDV-L-EE--VHYVSQLN-SSRFLKTCKA-LDP--NG- Vps15_Ddis MGNTVG--API-------VSEYLED-EIGP--IVFKKSLG-NARFLKTVKA-YHSE-EG- 15015_Tthe MSETKTISTLKKFD-IFA--------------LPFQFTFGNNEKEKKTIIGGLISM-AI- VPS15_Spur MGNQLT--GVAPSQ-ILPVEHYLTD-V-SD--YEFDHSLG-STRFFKVARA-KYK--EG- CC1G_08691_Ccin MGNVHS--GSTFTRTTGALDSYVAD-LGTD--IIYEKSLG-SSRFLKTVKC-KHR--NG- AqueK216_Aque MGNQLT--ALAPAQ-ILPMESYFHD-LP-D--FGKPVSLG-STRFMKVARS-KYT--DGT VPS15-1_Smoe MGNKLA--RTT--Q-ASPTEYYLND-LPSEFNLVLKEVIGKSERFFKAILC-VHD--EG- VPS15-2_Smoe MGNKLA--RTT--Q-ASPTEYYLND-LPSEFNLVLKEVIGKSERFFKAILC-VHD--EG- GK073_Glam MGNRLS--TLMSPG-IFSKK-YMIPWN-VK--VTSFEALN-TSRFLKSYHA-ENPQTKQ- *. :. . : * PIK3R4_Hsap LVVVKVFAIQDPTLPLTSYKQELEELKIRL--NSAQNCLPFQKASEKASEKAAMLFRQYV PIK3R4_Mmus LVVVKVFAIQDPTLPLTSYKQELEELKIRL--HSAQNCLPFQKAAEKASEKAAMLFRQYV CG9746_Dmel QIVVKVFVKHDPTLPLEDHKERLEGIKKTLSLANAVNCLPFQRVEL--IDKAAYIMREYV ZK930.1_Cele VFVYKVFVRQD-LASLDPFPQRIIDIRKALM--KSPNCCPIKKVLV--KQKYAVMVRAFQ VPS15_Scer EIVIKVFIKPKDQYSLRPFLQRIRAQSFKL--GQLPHVLNYSKLIE--TNRAGYMIRQHL Vps15_Ddis YVVVKIYKKRNTKESLEKYKIMLKEIKDNFNITPSFNIMPYQHFIE--TDRSGYLIRQYF 15015_Tthe LIVSSIY--------------------------------------------FGYLCYLYF VPS15_Spur LAVVKVFVIHDPSLPLRSFKEKIEDIKTRL--SNGSNCLPFLRSTL--SDKAALLFRQYV CC1G_08691_Ccin YLVIKIFVKPDPGLTLRNYHKRLKNDKESLV--DIANVYNYQVFVE--TERAGYIIRQWV AqueK216_Aque EVVVKIFPKIDSSVQLQMYEKRLHDINMRLR--FIANVLPYQNFWD--SDKAAFLVRQHV VPS15-1_Smoe LLLVKVYFKRGDVLDLREHARKLNEIREQFRNVENSHVWPFQRWHE--TDKAAYLLRQYF VPS15-2_Smoe LLLVKVYFKRGDVLDLREHARKLNEIREQFRNVENSHVWPFQRWHE--TDKAAYLLRQYF GK073_Glam DFILKVFVKLED-IDLSIFKFMLSHYREKINR-CCPHVLPYMGEYE--SKTHGFLIRPML : .:: . : PIK3R4_Hsap RDNLYDRI------STRPFLNNIEKRWIAFQILTAVDQAHKSGVRHGDIKTENVMVTSWN PIK3R4_Mmus RDNLYDRI------STRPFLNNIEKRWIAFQILTAVDQAHKSGVRHGDIKTENVMVTSWN CG9746_Dmel KHSLYDRV------STRPFLTVLEKKWITFQILCALNQCHKQKICHGDIKLENILITSWN ZK930.1_Cele KHTLFDRL------STRPFVVEAEKMWYIFLLFKALSQCETAGVCHGDLKSQNVLISSTN VPS15_Scer KNNLYDRL------SLRPYLQDIELKFIAFQLLNTLKDIHNLNIVHGDIKTENILVTSWN Vps15_Ddis HNNLYDRL------STRPFLSMIEKKFIAFQLLKALEQSSFKGVFHGDIKSENVLVTTSN 15015_Tthe QNKVQPQVVSSNIFQKSPYTMQFQQNFISVQVIMPNG----------------------- VPS15_Spur RNNLYDRI------STRPFLISIEKKWIAFQLLCALNQAHL------------------- CC1G_08691_Ccin ASNLYDRI------STRPFLTMVEKRWISFQLLNALRDARNRKVSHGDIKSENILVTSWN AqueK216_Aque QYNLYDRI------STRPYLNNIEKKWIVFQLLKALEGCHEKKVYHGDLKTENVLLTGWG VPS15-1_Smoe FSNLHERL------STRPFLSTIQKKWLAFQLLHAVKQSHDRGVCHGDIKCENVLVTSWN VPS15-2_Smoe FSNLHERL------STRPFLSTIQKKWLAFQLLHAVKQSHDRGVCHGDIKCENVLVTSWN GK073_Glam YQSLPEFI------LQNPWLTRGHKVLYSIQMILAVKEMHEAGLVHGDIKLSNFLVTHTH .: : *: . . :: . PIK3R4_Hsap WVLLTDFASF-KPTYLPEDNPADFNYFFDTSRRRTCYIAPERFVDGGMFATELEYMRDPS PIK3R4_Mmus WVLLTDFASF-KPTYLPEDNPADFNYFFDTSRRRTCYIAPERFVDGGMFATELEYMRDPS CG9746_Dmel WILLSDFASF-KPTYLPEDNPADYTYFFDTSRRRTCYIAPERFVKTLASDDDGG-NGNMS ZK930.1_Cele WLQITDFAPF-KPCFLTHDNPSSFTFFFDTSRRQSCYIAPERFISATEYDEKLRD----- VPS15_Scer WCILTDFAAFIKPVYLPEDNPGEFLFYFDTSKRRTCYLAPERFNSKLYQD---------- Vps15_Ddis WVYLSDFACY-KPTFIPEDNPADFSFYFDTSGRRTCYIAPERFYETNRGA---------- 15015_Tthe ------------------------------------------------------------ VPS15_Spur ----------------VGDNPADFSFFFDTSRRRTCYIAPERFVEGSSSRPVD-SATSET CC1G_08691_Ccin WVYLTDFASY-KPTYLPLDDPSDFSFYFDTSGRRTCYLAPERFYTQANNPDIS-AKKS-R AqueK216_Aque WVFLTDFASF-KPTLLPADNPADYTFFFDTSRRRNCYVAPERFVHASSYSQSS-S----- VPS15-1_Smoe WIYLTDFASF-KPTYIPDDNPADFSFFFDTGGRRRCYLAPERFYDPKTES---------- VPS15-2_Smoe WIYLTDFASF-KPTYIPDDNPADFSFFFDTGGRRRCYLAPERFYDPKTES---------- GK073_Glam SLMLTDFAPF-KPYQVSMSNPVALSYYFTD------TIAPERIVQADEELDT-------- PIK3R4_Hsap ---------------------------------------T-PLVDLN-SNQRTRGELKRA PIK3R4_Mmus ---------------------------------------T-PLVDLN-SNQRARGELKRA CG9746_Dmel VI-----------------------------------HTD-SIIR-L-APSYAGNTLLPA ZK930.1_Cele ----------------------------------------------G-QDEWLFGSLTPK VPS15_Scer -------------------------------------------------GKSNNGRLTKE Vps15_Ddis ---------------------------------------------------PSNNELTPK 15015_Tthe ------------------------------------------------------------ VPS15_Spur VEGLQVRQDVKGGELTPAMDIFSVGFVEGSSSRPVDNATSETVEGLQVRQDVKGGELTPA CC1G_08691_Ccin ---------------------------------------I-AA-MED-TPGKRDGKVTEA AqueK216_Aque --------------------------------------------ASD--SFQRNKPLTYE VPS15-1_Smoe -------------------------------------------------PVSPGGALKPS VPS15-2_Smoe -------------------------------------------------PVSPGGPLTPS GK073_Glam -----------------------------------------------------LLLPTME PIK3R4_Hsap MDIFSAGCVIAELFTEGVPLFDLSQLLAYRNGHFF-----PEQVL-NKIED--HSIRELV PIK3R4_Mmus MDIFSAGCVIAELFTEGVPLFDLSQLLAYRNGHFF-----PEQVL-NKIED--RSIRDLV CG9746_Dmel MDIFSAGCALLELWTEGTAPFELSQLLAYRRGERDL----VEKHL-AGIEN--ERLRNLL ZK930.1_Cele MDMFSAGCIVFELLCDR-PPFTYSSLCEYRSMNDAD---AGNMLL-RLIQDVPAPYRPLL VPS15_Scer MDIFSLGCVIAEIFAEGRPIFNLSQLFKYKSNSYDV---NREFLM-EEMNS--TDLRNLV Vps15_Ddis MDIFSLGCVIAELFLDGFPIFDFSQLLSYRKGEYS-----PEPIIRQRIQD--PNIQTLI 15015_Tthe -----------------QNLYDYQQQTG---KV----YL-NIISIN-FKSG--VNFKF-- VPS15_Spur MDIFSVGCVIAELFTEGNAPFDLSQLLAYCSGAYS-----PDAVL-EQIED--EHIKDLC CC1G_08691_Ccin MDCFSAGCVIAELFLEGAPLFTLSQLFKYREGELN-----VDTQL-ASIED--EGIRNLI AqueK216_Aque MDIFSLGCVTAELFLDGQLIFNLSELLDYCQKEFS-----PEPLL-KKITD--KYIKKMV VPS15-1_Smoe MDMFSLGCVIAELFLEGQALFDLSQLLGYRKRLYD-----PLPSL-EKISD--TGIKNMI VPS15-2_Smoe MDMFSLGCVIAELFLEGQALFDLSQLLGYRKRLYD-----PLPSL-EKISD--TGIKNMI GK073_Glam ADVFSLGSALLELWTSI-KPFDLPTLFEYRDAKTGNIINYVLSLL-DHITH--EELRGLV : : : PIK3R4_Hsap TQMIHREPDKRLEAED-YLKQQRGNAFPEIFY-TFL-QPYMAQFAKETFL---------- PIK3R4_Mmus TQMINREPEKRLEAED-YLKQQRGNAFPEIFY-TFL-QPYMAQFAKETFL---------- CG9746_Dmel ASMIDIHSMNRKSAED-YLDQERGQLFPEYFY-SFL-QSYLQMFSSTPIM---------- ZK930.1_Cele RLLLNRDPSFRISANA-VLTG-AALKFPHILE-SFL-FKYLDRFRPLYGTSTSSDP---- VPS15_Scer LDMIQLDPSKRLSCDE-LLNKYRGIFFPDYFY-TFI-YDYFRNLVTMTTSTPISDNTCTN Vps15_Ddis LHMIQKDPDQRYTPEK-YISKW-NTVFPQYF--SFA-HQFIPELMR---L---------- 15015_Tthe ------TPYPLIPCRDESLQ--GYLCLDSSKV-GDSD-NLFSLTYNPDNI---EENQ--- VPS15_Spur KHMLQKDPSKRMSAEQ-YLVKGRGTAFPEFFY-TFL-KVYMGEFAGVPIY---------- CC1G_08691_Ccin KEMIHLDPTARPTFDS-LLHTSRGTVFPETFY-SFL-HNYISTLNEPSPSTYSSTSSATT AqueK216_Aque RHMIQFKASDRRRPEQ-YLTMFKGLVFPEYFY-TFL-HDYFKSFTTATQL---------- VPS15-1_Smoe LQMIHVVPESRLSCDD-YLETWAYDVFPSYFS-PAL-HNLFSCLTRTMDL---------- VPS15-2_Smoe LQMIHIVPESRLSCDD-YLETWAYDVFPSYFS-PAL-HNLFSCLTRTMDL---------- GK073_Glam HAMINPIPSQRIDLST-L--QIRSIFTPEELFASDIILCFLKFFNP---L---------- . : PIK3R4_Hsap ----------------------------------------SADERIL------------- PIK3R4_Mmus ----------------------------------------SADERIL------------- CG9746_Dmel ----------------------------------------SPDDKIQ------------- ZK930.1_Cele --------------------------STDDFSQALEFSYLEPDDVIT------------- VPS15_Scer -------------------------STL-------EDNVKLLDETTE------------- Vps15_Ddis ----------------------------------------ENDDRVM------------- 15015_Tthe ---------------------------------------------FSI--MF--GICD-- VPS15_Spur ----------------------------------------PADEKIA------------- CC1G_08691_Ccin PGSTLPTGSMSVLRPHAPHSAPGSEPTP-------ETLANDSDHRME------------- AqueK216_Aque ----------------------------------------TPDQCIK------------- VPS15-1_Smoe ----------------------------------------ESDSRVNL--RFFLRSSSLF VPS15-2_Smoe ----------------------------------------ESDSRVNL--RFFLRSCSLF GK073_Glam ----------------------------------------NLDDVVHVGATLFDGICDMY PIK3R4_Hsap ----------VIRKDLGNIIH--------------------------------------- PIK3R4_Mmus ----------VIRKDLGNIIH--------------------------------------- CG9746_Dmel ----------CLHKDIGHCIK--------------------------------------- ZK930.1_Cele ----------KLKREKQLWWA--------------------------------------- VPS15_Scer ----------KIYRDFSQICH--------------------------------------- Vps15_Ddis ----------CISDKFDEIVDIFKNNSITNLFKSNLNQSTNSN--TI-GSFRVSTPSSPI 15015_Tthe --------------------------PNF------------------------------- VPS15_Spur ----------RLRKDMGSIMQ--------------------------------------- CC1G_08691_Ccin ----------RIWEDYESIEP--------------------------------------- AqueK216_Aque ----------KLYGDIEAILA--------------------------------------- VPS15-1_Smoe SN-----QVALIQSSFSEIRSLMIRDAKDKSFS--------AD--CLDKELRITSPSPPL VPS15-2_Smoe SN-----QVALIQSSFSEIRSLMIRDAKDKSFS--------AD--CLDKELRITSPSPPL GK073_Glam LNSSSSQKAALTKCYFCDIHHRFQFEQQQQQ-P--------DDQHASKKASTMARASSTI PIK3R4_Hsap ------------------------------------------------------------ PIK3R4_Mmus ------------------------------------------------------------ CG9746_Dmel ------------------------------------------------------------ ZK930.1_Cele ------------------------------------------------------------ VPS15_Scer ------------------------------------------------------------ Vps15_Ddis LISNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNQTTTTTTNTNINTTQQQQQQQQQQ 15015_Tthe ------------------------------------------------------------ VPS15_Spur ------------------------------------------------------------ CC1G_08691_Ccin ------------------------------------------------------------ AqueK216_Aque ------------------------------------------------------------ VPS15-1_Smoe Q----------------------------------------------------------- VPS15-2_Smoe Q----------------------------------------------------------- GK073_Glam N----------------------------------------------------------- PIK3R4_Hsap -------------------N-------LCGH-D-L-PEKAE------------------- PIK3R4_Mmus -------------------N-------LCGH-D-L-PEKAE------------------- CG9746_Dmel -------------------V-------LTQAQD-LTPEEEE------------------- ZK930.1_Cele -------------------------------------RLSE------------------- VPS15_Scer -------------------C-------LDFP-L-I-KDGGEIGSDPPILESYKIEIEISR Vps15_Ddis QQQLQRPLSKLDDIGKNIAN-------IIYKTEQFVKESDE-----------------FD 15015_Tthe ----------------------------I------------------------------- VPS15_Spur -------------------T-------LVAN-M-E-DGENN------------------- CC1G_08691_Ccin -------------------Y-------LCP--E--PSEDRT------------------- AqueK216_Aque -------------------N-------LFL--N---ST---------------------- VPS15-1_Smoe -------------------RKSRSSHAQTQH-D-L------------------------- VPS15-2_Smoe -------------------RKSRSSHAQTQH-D-L------------------------- GK073_Glam -------------------LGAQSSANITRF-D-L-PQDKK------------------- PIK3R4_Hsap -----------------------------------------GE----------------- PIK3R4_Mmus -----------------------------------------GE----------------- CG9746_Dmel -----------------------------------------KEEKKDPT-LCARLP---- ZK930.1_Cele -----------------------------------------ND----------------- VPS15_Scer FLNT--------NLY---FPQNYHLVLQQF-----------------TKVSEKIKS---- Vps15_Ddis KTDITNIKELNIQTTPTINTSTINRVIQTSKT--NTNLDTINENSNNNIGVNRKKV---- 15015_Tthe ---------------------------------------------QS------------P VPS15_Spur -----------------------------------------QR----------------- CC1G_08691_Ccin -MDV--------NID---YTSNVQAVFKPFQDVIPVELHIPNRDSKLRTHAGRRAA---- AqueK216_Aque --------------------------------------------------KQDRET---- VPS15-1_Smoe -------------------LTDINLLLKDSKS-----------S-IQHTKHQKSKV---- VPS15-2_Smoe -------------------LTDINLLLKESKS-----------S-IQQTKHQKSKA---- GK073_Glam -----------------------------------------HQ---------AKKPIEMP PIK3R4_Hsap --------------PKENGLVILVSVITSCLQTLKYCDSKLAAL-ELILHLAPRLSVEIL PIK3R4_Mmus --------------SRASGLVVLVSVITSCLQTLKSCDSKLAAL-ELILHLAPRLSVEIL CG9746_Dmel --------------PEHDGLILIITVVTSCIRGLKQSNTKIAAL-ELLQKLSKYTTSETI ZK930.1_Cele --------------ESKSFAFLFVSLITANLRALRTIQGKTDAI-RMLVELSTISDSSVA VPS15_Scer --------------VKEECALLFISYLSHSIRSIVSTATKLKNL-ELLAVFAQFVSDENK Vps15_Ddis --------------TVVEGLDLFLSVIYTAVKHCQFPSTKVKCVGSLLVRLAEMLDDECR 15015_Tthe Y----------------------------------------------------------- VPS15_Spur --------------HSNNGLVIVLSLVTSCLRSLKFCVSRLGAL-DIMLMIGKHLPDDII CC1G_08691_Ccin --------------LEDGPALIILASVTSNIRNCKLPSSKVRAL-DVFLALSCHLTDEAK AqueK216_Aque --------------GYGDVLVIVLSAITSNLRVAQFAGSKLQAI-EMMRTIANYVSDCSI VPS15-1_Smoe --------------PTHEGMVLIASALCACLRHVKLPFARRAAV-QLLYNASVLCDDDAR VPS15-2_Smoe --------------PTHEGMVLIASALCACLRHVKLPFARRAAV-QLLYNASVLCDDDAR GK073_Glam YLCTTNMEIPFKIIEQLDGTVLRSLATCDCVHRI-LKEGRTSEVS-------------WN PIK3R4_Hsap LDRITPYLLHFSNDS-VPRVRAEALRTLTKVLALVKEVPRNDINIYPEYILPGIA--HLA PIK3R4_Mmus LDRITPYLLHFSNDS-VPRVRAEALRTLTKVLALVQEVPRNDVNIYPEYILPGIA--HLA CG9746_Dmel LDRILPYILHLAQKS-PAKVQVQAIETLTACLGMVKDIPRSDANVFPEYILPSIT--DLA ZK930.1_Cele IDRILPYFVHLWMDP-ETQVRATAVTAVAELLAPIQPKTYEESLVFVDYLFPHLN--SMS VPS15_Scer IDRVVPYFVCCFEDS-DQDVQALSLLTLIQVLTSVRKLNQLNENIFVDYLLPRLK--RLL Vps15_Ddis LQKIVPYIMSMISPEQPTLVRVEALRSLAKVLEMVQTFPPSESSIFGQYILPSLS--QLS 15015_Tthe ------------------------------------------------------------ VPS15_Spur LDRIIPCILHFVHDP-FPRVRAEAIRTITQTLMLVKSVPRGDANIFPDYILPNLS--NIA CC1G_08691_Ccin LDRMVPYIVELLHDD-SALVRSAALRTLVQVLTLVSVITPSNVAIFPEYIIPNIK--HLV AqueK216_Aque LERIVPFLHLLIKDK-WPSVRAEAIRTLSFCLSVIRKVPRSDFNLFPEYILPVIL--MVP VPS15-1_Smoe LQLIVPFVAALLSDS-AAIVRCAALQTLCNVLSMVQTFSPSDAKVFPEYIFPLLS--MLP VPS15-2_Smoe LQLIVPFVAALLSDS-AAIVRCAALQTLCNVLSMVQTFSPSDAKVFPEYIFPLLS--MLP GK073_Glam CNVFGPFRRILASDTL----QAAMYHIAYSIMRLIQLDAFSISDTYKKGILTVCSYALFM PIK3R4_Hsap QD--------------------------------------D-ATIVRLAYAENIALLAET PIK3R4_Mmus QD--------------------------------------D-ATIVRLAYAENIALLAET CG9746_Dmel SE--------------------------------------TSAVIVRVAFARNIAALAKS ZK930.1_Cele NDS------------------------------------IDSPQHVLFAIATSLGQFADT VPS15_Scer ISN------------------------------------RQNTNYLRIVFANCLSDLAII Vps15_Ddis HE--------------------------------------STDEIIRIAFAEILPQLATT 15015_Tthe ------------------------------------------------------------ VPS15_Spur QD--------------------------------------P-IDMVRMVYAENIAVLAET CC1G_08691_Ccin QD--------------------------------------P-EVSVRCTYAQCIVPIADT AqueK216_Aque KD--------------------------------------I-DVQVRVALAESVAELALS VPS15-1_Smoe DD--------------------------------------P-EESVRICYADCIHKIAGT VPS15-2_Smoe DD--------------------------------------P-EESVRICYADCIHKIAGT GK073_Glam DDSYVSHLIRMAYRVFRLRPTAVTLGGVAYLLNLLTTAYQDIHYIPLLV-MGEVFLPKNQ PIK3R4_Hsap ALRFLELVQLKNLNMEN-DPNNEEIDEVTHP---------------------NGNY---- PIK3R4_Mmus ALRFLELVQLKTLNMEN-EPDNEEVDEATRP---------------------NGDY---- CG9746_Dmel AVYFLEETQRNAPN----D----------MP---------------------TPRY---- ZK930.1_Cele AYRFYMAGREIRQATMYD----DEVSTAGEQ---------------------Q-Q----- VPS15_Scer INRFQEFTFAQHCNDNS-MDNNTEIME---S---------------------STKY---- Vps15_Ddis AKRFLEIAQHYRDPDSEG--IM-ESRKDRAK---------------------FRVY---- 15015_Tthe ------------------------------------------------------------ VPS15_Spur ALRFLEMVQLDQ-NAAQ-SGETDGVQNPTQY---------------------QASY---- CC1G_08691_Ccin AVRYLEMGQALKAHGAFNLAAEGQDYEHAHY---------------------EISY---- AqueK216_Aque SHRFLELAQLQMNQEAAG--DEPSGVQY-QI---------------------YGTY---- VPS15-1_Smoe AYRFLVSQSS--------EGGSEELNEKS-R---------------------SAGF---- VPS15-2_Smoe AYRFLVSQSS--------EGGGEELNEKS-R---------------------SAGF---- GK073_Glam HDRFLEGVEIARHQLLD----VESLDEKAFESLANIFLYTAGSSSTTYPYLINHSYVIQL PIK3R4_Hsap --------------DTELQA-------------LHEM--------VQQKVVTLLSD--PE PIK3R4_Mmus --------------DTELQA-------------LHEM--------VQQKVVTLLSD--PE CG9746_Dmel --------------EAELNA-------------LHDI--------VRQAVLSLLTD--SQ ZK930.1_Cele --------------NDDAGA-------------LLHG--------VSA-MFSALCS--KE VPS15_Scer --------------SAK----------------LIQS--------VEDLTVSFLTD--ND Vps15_Ddis --------------DSDLQE-------------VQDQ--------FFNKVSDLLTK-DSC 15015_Tthe -----------------------------------------------------TCE--DE VPS15_Spur --------------DDELQN-------------LHGM--------IQQKVVTLLSD--PE CC1G_08691_Ccin --------------DASMQE-------------LQNH--------IQAHLAALLMD--PS AqueK216_Aque --------------DNELHQ-------------LHET--------FQSIVVHLLSD--ND VPS15-1_Smoe --------------TTELAQ-------------LRET--------IGRIIHDLVMGQKQT VPS15-2_Smoe --------------TTELAQ-------------LRET--------IGRIIHDLVMGQKQT GK073_Glam FPLLLASVARLSGGDPALKVIINAILLRNKTSLLYNILRSTSITPIILSSIRLL--SD-- PIK3R4_Hsap NIVKQTLMEN--GITRLC-VFFGRQKANDV------------------------------ PIK3R4_Mmus NIVKQTLMES--GITRLC-VFFGRQKANDV------------------------------ CG9746_Dmel PVVKQTLMES--GICDLC-AFFGKEKANDV------------------------------ ZK930.1_Cele PMVKRCLVES-KSLILLY-HFFIKIGNDDT------------------------------ VPS15_Scer TYVKMALLQN---ILPLC-KFFGRERTNDI------------------------------ Vps15_Ddis NTLKKIILSD---IYRLC-VFFGRQKTNES------------------------------ 15015_Tthe QVVRNTLISYSTQITARI-SFYTKFHLQKT------------------------------ VPS15_Spur NIVKRTLLEN--GITRLC-VFFGRQKANDV------------------------------ CC1G_08691_Ccin SVVKRAVLHN---ISSLC-VFLGRQKTNDV------------------------------ AqueK216_Aque SNVKRAFLTH--SAGKLC-TFFGAQKAKEV------------------------------ VPS15-1_Smoe PTIRRALLEH---IAPLC-EFFGKKQCNDF------------------------------ VPS15-2_Smoe PTIRRALLEH---IAPLC-EFFGKKQCNDF------------------------------ GK073_Glam NIVLISSLLP-G-ILPLYLDFLGRTDLRKITHFCLGDAIASIFGGCLDQLEPSCKHITSL : : * . PIK3R4_Hsap ---------------LLSHMITFLNDKN---DWHLRGAFFDSIVGVAAYVGWQSS-SILK PIK3R4_Mmus ---------------LLSHMITFLNDKN---DWHLRGAFFDSIVGVAAYVGWQSS-SILK CG9746_Dmel ---------------ILSHIMTFLNDE----DKNLRGAFYDNIAGVAGYVGWQAS-DILV ZK930.1_Cele ---------------LLRFLCTFLNAKT---EWRLRAAFFDSLP-VCV---QKRS-EGMV VPS15_Scer ---------------ILSHLITYLNDK----DPALRVSLIQTISGISILLGTVTLEQYIL Vps15_Ddis ---------------VLPLIITFLNDR----DWQLRCAFFENIVAVCTVVGAGSLESFIY 15015_Tthe ---------------DLTQQQGFIIQNS---DYDTY------FSGFARRDIFSSQ-QLIK VPS15_Spur ---------------LLSHMITFLNDKE---DWHLRGSFFDSIVGVAAYVGWQSS-FILK CC1G_08691_Ccin ---------------LLSHMITYLNDR----DWLLRYSFFESIVDVAACAGGRSLEEYIL AqueK216_Aque ---------------ILSHMITFLNDKS---NWELHIAFFEAIVDVVSQIVIR------- VPS15-1_Smoe ---------------LLPVLPAFLNDR----DKQLRALFFEQIVHVCIFVGEVSSEAYLL VPS15-2_Smoe ---------------LLPVLPAFLNDR----DKQLRALFFEQIVHVCIFVGEVSSEAYLL GK073_Glam KTTFQGARGAHSGKDIFFYVRIFLNNYHPLRDDKAAGTIFAAIL--------KS-ISIL- : :: : : PIK3R4_Hsap PLLQQGLSDAEEFVIVKALYALTCMCQLGLLQKPHVYEFASDIAPFLCHP---NLWIRYG PIK3R4_Mmus PLLQQGLSDAEEFVIVKALNALTCMCQLGLLQKPHVYEFASDIAPFLCHP---NLWIRYG CG9746_Dmel PLLQQGFTDREEFVIAKAIRAVTILIELGHIKKPAVTEIVQETACYLCHP---NLWVRHE ZK930.1_Cele PLLQLGLQDGEEHVVVRALGCIHILIKNENLDKMSVKKLLDDVLPFLVHP---NDWIRST VPS15_Scer PLLIQTITDSEELVVISVLQSLKSLFKTGLIRKKYYIDISKTTSPLLLHP---NNWIRQF Vps15_Ddis PCILLALTDEEEFVTEKALSSLSELCSLGLLRKPILLELLVKTSPMLLHP---NNWIRYG 15015_Tthe SQLQMNVLGALEFFLGSESISLN-------IQFP---QFTSLLAQFTSVF---------N VPS15_Spur PLLQQGLTDHEEQVICKALKSVTGLVQLGLLQKPALLEMAYELVPYVCHP---NLWIRQA CC1G_08691_Ccin PLMIQALSGA-------------------------------------------------- AqueK216_Aque ------------------------------------------------------------ VPS15-1_Smoe PYLEQALSNVEEPVIVNALECLAALCVYKLLKKRVLLKTVERASPLLCHP---SQWVRRA VPS15-2_Smoe PYLEQALSNVEEPVIVNALECLAALCVYKLLKKRVLLKTVERASPLLCHP---SQWVRRA GK073_Glam PLDLQS---TCIYLFCKS------------VYIPS-VQLSDDLGRSLWSPNNQNIWLLLN PIK3R4_Hsap AVGFI--------------------------------------TVVARQISTA------- PIK3R4_Mmus AVGFI--------------------------------------TVVAHQISTA------- CG9746_Dmel ICGMI--------------------------------------ATTARNLSAI------- ZK930.1_Cele VCDIL--------------------------------------LAIDCQWHNA------- VPS15_Scer TLMII--------------------------------------IEIINKLSKA------- Vps15_Ddis VVSLI--------------------------------------VKICQSLSKA------- 15015_Tthe SLLFL--------------------------------------GIISKFFAES------- VPS15_Spur TVGFI--------------------------------------AAIARSLNIA------- CC1G_08691_Ccin -AAFI--------------------------------------TSAAQQLPAS------- AqueK216_Aque ------------------------------------------------------------ VPS15-1_Smoe AITLV--------------------------------------AASGSNLSVA------- VPS15-2_Smoe AITLV--------------------------------------AASGSNLSGA------- GK073_Glam AIKTVIEKKDSQDALLFSFFLNDNLNQYVNIRLAGALMKILTLTVRSFDLSTQDSSQYAG PIK3R4_Hsap ----------------DVYCKLMP-YLDPYITQ---------PI---------------- PIK3R4_Mmus ----------------DVYCKLMP-YLDPYITQ---------PV---------------- CG9746_Dmel ----------------DVQCKIMP-AIGAFLKA---------PL---------------- ZK930.1_Cele ----------------EVHVKLIP-LVSPFVEES------KRGV---------------- VPS15_Scer ----------------EVYCILYP-IIRPFFEF---------DV---------------- Vps15_Ddis ----------------DVYCYVKP-KLSPFLVNLNGNGNGNAEI---------------- 15015_Tthe ----------------EIFSQVAEMQLKIYFKK---------SA---------------- VPS15_Spur ----------------DVHCNLTP-LLLPFLKK---------PI---------------- CC1G_08691_Ccin ----------------DIWCIVYP-SLRHFLKS---------DI---------------- AqueK216_Aque ------------------------------------------------------------ VPS15-1_Smoe ----------------DAHAYLIP-LLLPFLRR---------EP---------------- VPS15-2_Smoe ----------------DAHAYLIP-LLLPFLRR---------EP---------------- GK073_Glam VLIKRHVKQSVNDRRHQVMHIILP-KLSPVAPQIVEN------LHLFYPDLHKYSSFSDD PIK3R4_Hsap ------------------------------------------------------------ PIK3R4_Mmus ------------------------------------------------------------ CG9746_Dmel ------------------------------------------------------------ ZK930.1_Cele ------------------------------------------------------------ VPS15_Scer ------------------------------------------------------------ Vps15_Ddis ------------------------------------------------------------ 15015_Tthe ------------------------------------------------------------ VPS15_Spur ------------------------------------------------------------ CC1G_08691_Ccin ------------------------------------------------------------ AqueK216_Aque ------------------------------------------------------------ VPS15-1_Smoe ------------------------------------------------------------ VPS15-2_Smoe ------------------------------------------------------------ GK073_Glam VSTHHDPDYDIQHEVLRKIQENYALIERLTFLTIDDLTNPQRYLFMLQEIVHAASTIIEN PIK3R4_Hsap -----------IQIERKLVLLSVLKEPVSRSIFDYALRSKDITSLFRHLHM------RQK PIK3R4_Mmus -----------IQIERKLVLLSVLKEPVSRSIFDYALRSKDIASLFRHLHM------RQK CG9746_Dmel -----------IQVEKPHILLDCVHPPVPRQIFDSVLRFQDIHHFIRALEA------RSR ZK930.1_Cele -----------LTLKSKPVLMSQLVDPIPRTTFNQIIDQSLENTKQITML--L----EIH VPS15_Scer ------------EFNF-KSMISCCKQPVSRSVYNLLCSWSVRASKS--LFW--KKIITNH Vps15_Ddis -----------SDTITESNLIQLLDSPISRESFNKIVKFIARNRIN--LSSSINSILAND 15015_Tthe -----------LFILK-------------------------------------------- VPS15_Spur -----------IQIDKEAIIMSVLKCPVSRAVYDYILRSPIIIDFFDNLTD------RQL CC1G_08691_Ccin -----------GEINT-SSLLRAMKPPLPRQILDSSVQWAMKADRS--VFW------SRP AqueK216_Aque ------------------------------------------------------------ VPS15-1_Smoe -----------LSISSEAALLACLKPPVSRDVFQRVLSNVMLTSNSTEAAT------ERP VPS15-2_Smoe -----------LSISSEAALLACLKPPVSRDVFQRVLSNVMLTSNSTEAAT------ERP GK073_Glam LTTFVQQIAISTSIN-TDNLQEKHEENLPLYLLVKDMPTAPDAN---------------- PIK3R4_Hsap ------------KRN------GS-------------------------LPDCP------- PIK3R4_Mmus ------------KRN------GS-------------------------LLDCP------- CG9746_Dmel ------------VRSQ-T-RQGA-------------------------LPQYE------- ZK930.1_Cele ------------FQT------GK-------------------------PFEAG------- VPS15_Scer VDSFGNNRIEFITKNYSSKNYGFN------------------------KRDTKSSSSLKG Vps15_Ddis NDNFNGESF---NSNG--SGGGGNPNLVSSTGGSNRRLRALSNKFFVPNILSASNSSIN- 15015_Tthe ----------------------------------------------------Q------- VPS15_Spur ------------IRNL-CIRPGH-------------------------KPEYN------- CC1G_08691_Ccin ------------------RRGGS-------------------------KTESPRESVIS- AqueK216_Aque ------------------------------------------------------------ VPS15-1_Smoe ------------KPR------QR-------------------------VPDAT------- VPS15-2_Smoe ------------KPR------QR-------------------------VPDAT------- GK073_Glam ------------------------------------------------------------ PIK3R4_Hsap ------------------------------------------------------------ PIK3R4_Mmus ------------------------------------------------------------ CG9746_Dmel ------------------------------------------------------------ ZK930.1_Cele ------------------------------------------------------------ VPS15_Scer IKTSSTVYSHDNKE---------------------------------------------- Vps15_Ddis S-TSGDI---GSLL---------------------------------------------- 15015_Tthe ------I---GQGENIQRDQKQGLEKLLSYIKNADFKNLGKKMKISFFRKIMYVFMGNIK VPS15_Spur ------------------------------------------------------------ CC1G_08691_Ccin V-RKAGT---GNLA---------------------------------------------- AqueK216_Aque ------------------------------------------------------------ VPS15-1_Smoe ------------------------------------------------------------ VPS15-2_Smoe ------------------------------------------------------------ GK073_Glam ------------------------------------------------------------ PIK3R4_Hsap PPEDPAI-AQLLKKLLSQGMTE----EEEDKLLALKDFMMKSNKAKANIV---------- PIK3R4_Mmus PPEDPTI-AQLLKKLLSQGMTE----EEEDKLLALKDFMMKSNRAKANAV---------- CG9746_Dmel E-MGQTL-RNLFRRLSSEGLTD----LIEMQLLAMNPFLISMKHKAL--Q---------- ZK930.1_Cele AGWFNTI-FPKIKTETKAGVVEH-----NDLKAALEAR-KRLTASVYSFR---------- VPS15_Scer IPLTAED-INWIDKFHIIGLTE----KDIWKIVALRGYVIRTARVMAANP---------- Vps15_Ddis SQSTEES-LAFLRQMTSIGISD----SDQNKIIKCFDYLQSKKCKDLESANNSEGNVIVI 15015_Tthe NEKKETIQEKLFKQIVSQSNKALNIFEIQKELLQMKI-MMRLI----------------- VPS15_Spur ELEIGQM-AQLLRKLQSQGMTE----EDEDKLLFLREIMLKQSKAKIGMG---------- CC1G_08691_Ccin KNRSEED-EVHINKLQQLGLTS----SDESKLLAMRDYILKLANATASFS---------- AqueK216_Aque ------------------------------------------------------------ VPS15-1_Smoe FGHGR---TPMMKIPLQRNVPDF---EDGEKLKAMEGYIRNLSSTMHS-W---------- VPS15-2_Smoe FGHGR---TPMMKIPLQRNVPDF---EDGEKLKAMEGYIRNLSSTMHS-W---------- GK073_Glam ----PS----------FSGMHA----RTQDDILHSSKELSR------------------- PIK3R4_Hsap --------------------D-----QS------------HLHDSSQKGVID---LAALG PIK3R4_Mmus --------------------D-----QS------------HLHDSSQKGVID---LAALG CG9746_Dmel --------------------D-----LDDT--------------ASGNGRIV---VSRKQ ZK930.1_Cele --------------------K-----LFERMAETRNTAGMEIYLTRQLGTID---LSSIA VPS15_Scer --------------------D-----FPYN--------NSNYRPLVQNSPPN---LNLTN Vps15_Ddis RTNGTTIISSSNNSNNNTLSSST---TSSN--------STTPTN----STVN-----LHS 15015_Tthe -----------------------------------------------LSVEQ---YAAIQ VPS15_Spur --------------------D-----LSNQ--------SSSPHDPFTPGQVN---LSVYP CC1G_08691_Ccin -------------------SR-----LSYE--------PDTGKNLKVTGDLE---LQKLG AqueK216_Aque ------------------------------------------------------------ VPS15-1_Smoe --------------------D-----LENP----------EKMDASATGAGF---FSNFD VPS15-2_Smoe --------------------D-----LENP----------EKMDASATGAGF---FSNFD GK073_Glam ----------ANFSASQRMDFRSLTSLND---------VSIWTDASVSRVAEELVYAGHG PIK3R4_Hsap ITG-RQVDLVKT-----------------KQEPDDKRARKH-VKQ--------------- PIK3R4_Mmus ITG-RQVDLVKT-----------------KQEPDEKRARKH-VKQ--------------- CG9746_Dmel ---------VAC-----------------HEYPLADKAS-K-MPL--------------- ZK930.1_Cele HSR-----------------------VRRKEF---------------------------- VPS15_Scer IMP-RNIFFDVEFAEEST-SEGQDSNLENQQIYKYDESEKDSNKL--------------- Vps15_Ddis VLN-NTTIIQQQ--QQQLQQTIT------Q---------QS-ITQQQQQQQQQ------- 15015_Tthe LC-GSKLPICND-----------------KQK---------------------------- VPS15_Spur AIQKNHADLIKP--PDLR-SEVT------DKAQTKKSKKKQ-SAI--------------- CC1G_08691_Ccin VVP-QTVFLKQR--QDSG-SRMT------I-----PSSRRS-ISSRTSAMSPR------- AqueK216_Aque ---------------------------------------KE-L----------------- VPS15-1_Smoe VA---------T-----------------DSIPLYSRPPTD-RRL--------------- VPS15-2_Smoe VA---------T-----------------DSIPLYSRPPTD-RRL--------------- GK073_Glam SS-GSRHLIVSN--EYQV------------LLKDGERARHV-VEL-------FYGPVGDA PIK3R4_Hsap ------------------------------------------------------------ PIK3R4_Mmus ------------------------------------------------------------ CG9746_Dmel ------------------------------------------------------------ ZK930.1_Cele ------------------------------------------------------------ VPS15_Scer ------------------------------------------------------------ Vps15_Ddis --Q--------------------------------------------------------- 15015_Tthe ------------------------------------------------------------ VPS15_Spur ------------------------------------------------------------ CC1G_08691_Ccin --F--------------------------------------------------------- AqueK216_Aque ------------------------------------------------------------ VPS15-1_Smoe ------------------------------------------------------------ VPS15-2_Smoe ------------------------------------------------------------ GK073_Glam KDRMKEILFGKDQEASIEDTSVQYSTYSLIPEISTLPDESVLHSTLFSSLLSACKPFLIT PIK3R4_Hsap ---------------------------------------DSNVNEEWKSMFG--SL---- PIK3R4_Mmus ---------------------------------------DSNVNEEWKSMFG--SL---- CG9746_Dmel ---------------------------------------DNRSSEG-------------- ZK930.1_Cele ----------------------------------------TYGGDE-------------S VPS15_Scer ---------------------------------------NINGSKQLSTV---------- Vps15_Ddis --------QVSGGITTGGT------TTTTLGR-SSSPQLTGLNP------SI--LS---- 15015_Tthe ------------------------------------------------------------ VPS15_Spur ---------------------------------------DPAMNEEWRSMFG--TAADTK CC1G_08691_Ccin --------PRPPSIDHGSV------G-TGAPFEDLRRRLASINNSVSSLSPN--QPKDAR AqueK216_Aque ------------------------------------------------------------ VPS15-1_Smoe ---------------------------------------DNSGNEEWSRIYR--QPMDTL VPS15-2_Smoe ---------------------------------------DNSGNEEWSRIYR--QPMDTL GK073_Glam DASASIRNMLRPGILSGYLCKSLNMQSVVLAR-RWLPFL------------RESSL---- PIK3R4_Hsap -----------------------DPPNMP------------------------------- PIK3R4_Mmus -----------------------EPPNIP------------------------------- CG9746_Dmel ----------------------------P------------------------------- ZK930.1_Cele A---------------------------M----------------------S-------- VPS15_Scer ------------------------------------------------------------ Vps15_Ddis -N---------------------SNNIQL----------------------S-------- 15015_Tthe ------------------------------------------------------------ VPS15_Spur PIKASQQQTSINTPPLHPSGGDLPPPHAP------------------------------- CC1G_08691_Ccin SV---------------------SSPLAP----------------------S-------- AqueK216_Aque ------------------------------------------------------------ VPS15-1_Smoe A----------------------------------------------------------- VPS15-2_Smoe A----------------------------------------------------------- GK073_Glam -----------------------PPSALPKLLNTLLNNLLIISPGTHSLPTSNSLIQHVC PIK3R4_Hsap ------------------QALP------KGSDQEVI----Q----T----GKP---PRSE PIK3R4_Mmus ------------------QALP------KTSDHEVV----Q----P----GKP---PRSE CG9746_Dmel ------------------TLAS------PASDAAITPL--GAGGLA----GSP---ASGA ZK930.1_Cele ------SNSKHLTAINIPNHST------ERRDTLL-----LAGEVV----IEE---ER-- VPS15_Scer ------------MD--------------------------INGSLI-------------- Vps15_Ddis ------SSVVDVTKLP--NSIPIRMVKIRGGDQSLNNSTVSLGSVAGGNIITP---STSL 15015_Tthe -----------------------------EQDQEVIE--------E----SQI---SN-- VPS15_Spur ------------------VQRS------ASKAAPQK----PPGGQD----QTP---PSSA CC1G_08691_Ccin ------SSSISVASAT--APSPVA-----------------AERER----DRP---PSPT AqueK216_Aque --------------------------------------------------SSP---PHTQ VPS15-1_Smoe ---------------------Y------SQSDMMQK----------------S---MMQK VPS15-2_Smoe ---------------------Y------SQSDMMQK----------------S---MMQK GK073_Glam KQFKVEDM---LSDK--PTEIGREFITIPGLQHDLKNTSV------------IITYQNPL PIK3R4_Hsap ------------------------------------------------------------ PIK3R4_Mmus ------------------------------------------------------------ CG9746_Dmel ------------------------------------------------------------ ZK930.1_Cele ------------------------------------------------------------ VPS15_Scer ------------------------------------------------------------ Vps15_Ddis S---------------------------------NSNTMVGNNNNNSYNTS--------- 15015_Tthe ------------------------------------------------------------ VPS15_Spur Q---------------------------------AQ------------------------ CC1G_08691_Ccin E---------------------------------SV--------VSNAN-S--------- AqueK216_Aque S---------------------------------Q------------------------- VPS15-1_Smoe ------------------------------------------------------------ VPS15-2_Smoe ------------------------------------------------------------ GK073_Glam AYSRHELVKYIVAETQVALDFISMRANPRGDLIMNSKTIQGMQSNNPLYTHYSNLIRAAS PIK3R4_Hsap ------------------------------------------------------------ PIK3R4_Mmus ------------------------------------------------------------ CG9746_Dmel ------------------------------------------------------------ ZK930.1_Cele ------------------------------------------------------------ VPS15_Scer ------------------------------------------------------------ Vps15_Ddis -----------TSSSPLS-----------------------SSVLNSSVGMNNL------ 15015_Tthe ------------------------------------------------------------ VPS15_Spur ---------------P--------------------------------------QPQGQL CC1G_08691_Ccin -----------VSLRPASRLQVGSVEGSKAAPAVGSSKTVATGLLDAHSHIGSPDPS--- AqueK216_Aque ------------------------------------------------------------ VPS15-1_Smoe ------------------------------------------------------------ VPS15-2_Smoe ------------------------------------------------------------ GK073_Glam DLIINASITHHVNKTP-------------------------------------------- PIK3R4_Hsap ----------SSAGICV----------------------------------------PLS PIK3R4_Mmus ----------SSAGICV----------------------------------------PLS CG9746_Dmel ----------VVLG--V----------------------------------------PTA ZK930.1_Cele ----------TVTN--T----------------------------------------PA- VPS15_Scer ------------------------------------------------------------ Vps15_Ddis -----------------TNSNANSINNSSGINNNNSNNNSVNSNNYNNMNNNTMNN---- 15015_Tthe ----------QIVS---------------------------------------------- VPS15_Spur KQQQQAAQQQAQQGVDAK----------AATQRQNHKTDAAQGGGKGQINKGLMANEPIR CC1G_08691_Ccin -----------------GR----------------------------------------- AqueK216_Aque ------------------------------------------------------------ VPS15-1_Smoe ----------SIIA--I----------------------------------------PSK VPS15-2_Smoe ----------SIIA--I----------------------------------------PSK GK073_Glam ----------------------------------------------------------YR PIK3R4_Hsap -------------------------------------------------------TSSQV PIK3R4_Mmus -------------------------------------------------------TSPQV CG9746_Dmel -------------------------------------------------------T---V ZK930.1_Cele ------------------------------------------------------------ VPS15_Scer -------------------------------------------------------FKNKS Vps15_Ddis --------------------------------------------------------SVNL 15015_Tthe ------------------------------------------------------------ VPS15_Spur -------------------------------------------------------MSQLQ CC1G_08691_Ccin --------------------------------------------------------SSPL AqueK216_Aque ------------------------------------------------------------ VPS15-1_Smoe ------------------------------------------------------------ VPS15-2_Smoe ------------------------------------------------------------ GK073_Glam ALLPANSVSLNDIQGPLERIGTIQSKLAYDFVANDHVSMTSKNMTLPGCVQTRVSYNYAS PIK3R4_Hsap PE-VTTVQNKKPVI-----------------------------PVL----------SSTI PIK3R4_Mmus SE-AAHIPSKKPVI-----------------------------PVV----------SSTV CG9746_Dmel SA-ATSLGEY--TM-----------------------------PER----------N--- ZK930.1_Cele ---------------------------------------------P----------YSPV VPS15_Scer IA-TTTSNLKNVF--------------------------------------------VQL Vps15_Ddis MN-SNQIGQQQQQN-----------------------------PNTVKIDLVSPSDLNVV 15015_Tthe ------------------------------------------------------------ VPS15_Spur AA-AEGIPVKKPVQ--------------------------------------------ES CC1G_08691_Ccin SM-SATLRQHRPRV-----------------------------P-------------SLL AqueK216_Aque ------------------------------------------------------------ VPS15-1_Smoe -----------------------------------------------------------F VPS15-2_Smoe -----------------------------------------------------------F GK073_Glam LKSFTYSAIGNMFIILDAKNYIHFYLNPVDEAIKFLAQRILLLSRTVKISMESSPEAHA- PIK3R4_Hsap LPSTYQIRITT--CKTELQQLI------------------QQKREQCNAE---------- PIK3R4_Mmus LPSTYQIRITT--CKTELQQLI------------------QQKREQCNAE---------- CG9746_Dmel ---CWLERSSE--CRKDLESLT------------------AKIKSRYNVL---------- ZK930.1_Cele KNTTFDNQVNE--MLAHLNELHMRNVNCRPK-----R--------PLAAS---------- VPS15_Scer EPTSYHMHSPN--HGLKDNANV------KPE-----RKVVVSNSYEGDVE---------- Vps15_Ddis SK-KYYIRDPKMGLSTILK---------------------VETNVECSIKVPLPLPDLGS 15015_Tthe ---------------------V------------------DQKLEKSNEI---------- VPS15_Spur KPVASHIQVSS--CHLNLRSLV------------------TRKRDQYAMD---------- CC1G_08691_Ccin PISTYDGQEPG--ISNLLENLY------------------LDNNRELQQDFGPPVHE--- AqueK216_Aque ------------------------------------------------------------ VPS15-1_Smoe TGSIY-GRTPS--HET---------------------------STEPAFD---------- VPS15-2_Smoe TGSIY-GRTPS--HET---------------------------STEPAFD---------- GK073_Glam DHYSV-LAGLPQG--LPQLQN-------EPKHQKITAPVLTSSPALESLE---------- PIK3R4_Hsap ------------------------------------------------------------ PIK3R4_Mmus ------------------------------------------------------------ CG9746_Dmel ------------------------------------------------------------ ZK930.1_Cele ------------------------------------------------------------ VPS15_Scer ------------------------------------------------------------ Vps15_Ddis TDSVLGGGLLSSGGVGGGVGGTGGGNINGVSGINGNVGGGGGGVGVGTVGSGGNGSIGGG 15015_Tthe ------------------------------------------------------------ VPS15_Spur ------------------------------------------------------------ CC1G_08691_Ccin ------------------------------------------------------------ AqueK216_Aque ------------------------------------------------------------ VPS15-1_Smoe ------------------------------------------------------------ VPS15-2_Smoe ------------------------------------------------------------ GK073_Glam ------------------------------------------------------------ PIK3R4_Hsap --------------------------RIAKQMME-------------NAEWESKPPPPGW PIK3R4_Mmus --------------------------RIAKQMME-------------NAEWESKPPPPGW CG9746_Dmel --------------------------AISQRCSY-------------DK--LVTPYPPGW ZK930.1_Cele --------------------------ASHPVLSA-------------SPSAGSLGSSSNN VPS15_Scer --------------------------SIEKFLSTFKILPPLRDYKEFGPIQEIVRSPNMG Vps15_Ddis NSGINNGSGGGGVNSGGNSGINSGSTNSSGSLYG-------------NGNGLDNLPNSTW 15015_Tthe --------------------------KEDKQNFE-------------D------------ VPS15_Spur --------------------------IMRKMLIH-------------DTTFNAKAPQSNW CC1G_08691_Ccin -------------------------GPIRRRNTS-------------R-HPFGTRDITNK AqueK216_Aque ------------------------------------------------------------ VPS15-1_Smoe --------------------------AFNKFL------------------KSSAGSDSRW VPS15-2_Smoe --------------------------AFNKFL------------------KSSASSDSRW GK073_Glam --------------------------SIMEYLSTGVL----------------TLPLATF PIK3R4_Hsap RPKGLLVAHLHEHK--------SAVNRIRV-SD-EHSLFATCSNDGTVKIWNSQKMEGK- PIK3R4_Mmus RPKGLLVAHLHEHK--------SAVNRIRV-SD-EHLLFATCSNDGTVKIWNSQKMEGK- CG9746_Dmel RMTGTLVAHLHEHS--------ESVIKLASLRP-HGSLFASGSIDGTVRLWDCSKLNGN- ZK930.1_Cele NVKGIIITHLHEHS--------GKITKLCA-NR-ESDLFLSGSTDGTVKVWKTRSVLGEG VPS15_Scer NLRGKLIATLMENEP-------NSITSSAV-SPGETPYLITGSDQGVIKIWNLKEIIV-- Vps15_Ddis RPMGILVSHFFEHK--------AAVNEIQV-SS-DNLFFATASNDGTVKIWDCQRMEK-- 15015_Tthe ------------------------------------------------------------ VPS15_Spur KPRGLLIAHLHEHK--------GAVNRLQV-SY-DHTLFSTCSDDGTVKVWDCTKLIGK- CC1G_08691_Ccin RLEASLISNLTSHS--------EAITGIAV-SP-DHAFFVTASDDKTVKVWDTARLER-- AqueK216_Aque ------------------------------------------------------------ VPS15-1_Smoe RPRGVLVSHLHEHQ--------RAVNQVAV-SS-DNSFFTSASDDGTVKVWDCRRLER-- VPS15-2_Smoe RPRGVLVSHLHEHQ--------RAVNQVAV-SS-DNSFFTSASDDGTVKVWDCRRLER-- GK073_Glam HIPGVSILHIFVDPCGIPILGGGKATEKKSV-RHEFLALNIVTDSCVVKLLVDPDMLIQQ PIK3R4_Hsap T-----------TTTRSIL-TYSR-IGGRVKTLTFCQGSHYLAIASDNGAVQLLGIEASK PIK3R4_Mmus T-----------TTTRSIL-TYSR-IGGRVKTLTFCQGSHYLAIASDNGAVQLLGIEASK CG9746_Dmel Q-----------GVNKSRQ-VYSA--NTPIYALAACDSGQSLAVGGKDGSMLMMRIDRN- ZK930.1_Cele Y-----------GSARSED-TWIPTETSREKVNSVGWNDQFACSATNDGFVRWADVGQGS VPS15_Scer G-----------EVYSSSL-TYDC--SSTVTQITMIPNFDAFAVSSKDGQIIVLKVNHYQ Vps15_Ddis S-----------VTNRARQ-TYAQ-QEGRITSISICEKTHSIASASDKGSIHVFRVGISG 15015_Tthe ------------RTQNNIL-SFSR-EK-------------QESVRKFNGTVYPISIEQQI VPS15_Spur A-----------NTNKSRQ-TYNR-QPGKIKTLTFCQSSHSIASGSDDGSIHVNRIEAS- CC1G_08691_Ccin N-----------VTSKARH-TYNQ-HHARVKCVCIIEGTHCFASAAEDGSLHVVRVQLTQ AqueK216_Aque -----------------------------------CQ----------------------- VPS15-1_Smoe S-----------TSFRSKL-TYSFGQNERVLCLAMLSPDQQVAAASSAGEIRVLCVDYIA VPS15-2_Smoe S-----------TSFRSKL-TYSFGQNERVLCLAMLSPDQQVAAASSGGEIRVLCVDYIA GK073_Glam YTEAILVTDSNCNANRAGGVTFS-M-NDAVFSLSISGSGKSVELV-DFGMLHKTQLNGAL PIK3R4_Hsap LP--------KSPKIH-----------PLQS-RILDQKEDG---CVVDMHHFNSGAQS-- PIK3R4_Mmus LP--------KSPKIH-----------PLQS-RILDQKEDG---CVVDMHHFNSGAQS-- CG9746_Dmel -----------SAKMT-----------LQQA-LNQNDHKDG---PVVDMHAYDQATQS-- ZK930.1_Cele ------------ARVA-----------T-Q--VRIP-DAEG---PPVYLHCNG----P-- VPS15_Scer QE--------SEVKFL-----------NCECIRKINLKNFGKNEYAVRMRAFVNEEKS-- Vps15_Ddis KQK------NGNIKYT-----------NLSTVKNITETTRG---NIVSVSHYSTNSSS-- 15015_Tthe ------------------------------------------------------------ VPS15_Spur -----------PPRLA-----------PLDK-RQLNVSEEG---VPVDLAHFDTGPQS-- CC1G_08691_Ccin SAAGASSAAGSLPKYG-----------KLQVVREHRVESVG--EWITCMVHYKSDSTS-- AqueK216_Aque ------------------------------ITR--------------------------- VPS15-1_Smoe REG------NVPERYS-----------GISNVR-RTDAQEG---SVLALQAFG----G-- VPS15-2_Smoe REG------NVPERYS-----------GISNVR-RTDAQEG---SVLALQAFG----G-- GK073_Glam T-------E-NTIQYLLPYLTADQICTFLKAYHNDSVTEKS-SAPKV-THLYMHSTLSAS PIK3R4_Hsap ----------------------------------------------------VLAYATVN PIK3R4_Mmus ----------------------------------------------------VLAYATVN CG9746_Dmel ----------------------------------------------------VIVYATLY ZK930.1_Cele ----------------------------------------------------MAIVRTHH VPS15_Scer ----------------------------------------------------LLVALTNL Vps15_Ddis ----------------------------------------------------VVTYATTK 15015_Tthe ------------------------------------------------------------ VPS15_Spur ----------------------------------------------------ILVYATSQ CC1G_08691_Ccin ----------------------------------------------------SLVYATTH AqueK216_Aque ------------------------------------------------------------ VPS15-1_Smoe ----------------------------------------------------MLLYSTQK VPS15-2_Smoe ----------------------------------------------------MLLYSTQK GK073_Glam LDHANGVELLLTRLRYKNQFPLNLKSAESQVYSVMPHRILTYYNCYLLSEIVAILSTTVV PIK3R4_Hsap GSLVGWDLRS--------SSNAWTLKHDLKSGLI-TSFAVDI-HQCWLCIGTSSGT--MA PIK3R4_Mmus GSLVGWDLRS--------SSNAWTLKHDLKSGLI-TSFAVDI-HQCWLCIGTSSGA--MA CG9746_Dmel GGIVAWDTRM--------QHSAWRLQNELRHGVI-TTICADP-TGSWLATGTSGGK--HI ZK930.1_Cele GVLYGIDLRVGASEGPLKRHDIWRKKFQESHGLV-TSSAIDPWQQSWMVIGNNSGQKNLV VPS15_Scer SRVIIFDIRT--------LERLQIIENSPRHGAV-SSICIDE-ECCVLILGTTRGI--ID Vps15_Ddis GGIHGWDLRS--------QQDAFNLVNDASLGLI-QAFLIDP-NRNWLVTGTSRGF--LT 15015_Tthe ------------------------------------------------------------ VPS15_Spur GYLVGWDLRS--------PTEAFRLRNQQRHGALVRRVRLHP-SQ--------------- CC1G_08691_Ccin SNIAILELRT--------MRVLQTMENPRHYGPI-TAMCMDK-RRAWLVVGTSTGV--LT AqueK216_Aque -----------------------GVRNEEKSGTL-------------------------- VPS15-1_Smoe NGLHLWDFRE--------QRDAWLLKAKPEQGYV-SALAADP-SRHWLVSGTSRGV--LT VPS15-2_Smoe NGLHLWDFRE--------QRDAWLLKAKPEQGYV-SALAADP-SRNWLVSGTSRGV--LT GK073_Glam TCTALYDGTS--------GNRMYTL--PKEFGE-IQYACES-AS-GSIAVLTSMG--WLI PIK3R4_Hsap CWDMRFQLPISSHCHPS------RARIRRLSMHPLY-----QSWVIAAVQ--------GN PIK3R4_Mmus CWDMRFQLPISSHCHPS------RARIRRLSMHPLY-----QSWVIAAVQ--------GN CG9746_Dmel CWDLRFRLPIAEIKHPA------DSWIRKVACHPTE-----PSYLISASQ--------SN ZK930.1_Cele LYDLRFKEEVLRWESPHQNTQPNR-----VWANPVSRQECPEVF-VG-FS--------MH VPS15_Scer IWDIRFNVLIRSWSFGD------HAPITHVEVCQFYG---KNSVIVVGGS--------SK Vps15_Ddis CWDLRFGIPLYSVRVSN-------GRILKFAPYMLAKS-ASESWVYIST---------EQ 15015_Tthe ------------------------------------------------------------ VPS15_Spur -----------------------------------------QSLVISAVQ--------GN CC1G_08691_Ccin LWDKRFGILLKSWQTAAATSSGKSCKVHQIAVHPTKG---RGKWIIVALETSKKGLASSR AqueK216_Aque ------------------------------------------------------------ VPS15-1_Smoe LWDLRFQVQVYSWRLPSC------HPVE-AMCVPVGSS-LPRPFVYV-AA--------GR VPS15-2_Smoe LWDLRFQVQVHSWQLPSC------HPVE-AMCVPVGSS-LPRPFVYV-AA--------GR GK073_Glam LLEFRAGNLLDLWV---------------------------------------------- PIK3R4_Hsap N---EVSMWDMETG-DRRFTLWASS-APP---LSE--LQP----S--------------- PIK3R4_Mmus N---EVSMWDMETG-DRRLTLWASS-APP---LSE--LQP----S--------------- CG9746_Dmel N---EVSVWNIETG-QRQTVLWASP-VAA---LSS--ASP----S--------------- ZK930.1_Cele G---EISTYELSAQPLRKRVFWTGG-API---LSY--SAA----S--------------- VPS15_Scer T---FLTIWNFVKG-HCQYAFINSDEQPS---MEH--FLP----IEKGLEEL--NFCGI- Vps15_Ddis D---NVIVFDLSNK-KTTRVFKRSYEQPP---QQQ-PQQP----QPPQQQQQQQSQMNRS 15015_Tthe ------------------------------------------------------------ VPS15_Spur N---EVSMWDMETG-ARRFTLWASP-HPP---LSQ--TQ--------------------- CC1G_08691_Ccin DSVTIIEVWDVEKS-VLVETFVVGTSSDRER-EREGSESP----GPHEVE-VEGVDANPS AqueK216_Aque ------------------------------------------------------------ VPS15-1_Smoe N---EVAVWNVENG-NCQQILKSAVQSNGTSFV--ANLQPWGRRTGPKQQHQEASK---- VPS15-2_Smoe N---EVAVWNVENG-NCQQILKSGVQSNGTSFV--ANLQPWGRRTGPKQQHQEASK---- GK073_Glam ----------LAEK-QRYNVHRYSA-ILG---FN-GLLSPT------HSFTHEAEE---- PIK3R4_Hsap ------------------------------------------------------------ PIK3R4_Mmus ------------------------------------------------------------ CG9746_Dmel --------------------------------D--------------------------- ZK930.1_Cele --------------------------------N--------------------------D VPS15_Scer ------------------------------------------------------------ Vps15_Ddis INMTSSTTTTTTSSYDFGTENLKTSSYSQLPSNPLVNSIVNNSNINNNNNNNDNSNNVTI 15015_Tthe ------------------------------------------------------------ VPS15_Spur ------------------------------------------------------------ CC1G_08691_Ccin --PAAA-IAAFVRSRQLQSENERRSSAR------------------------GSANEELV AqueK216_Aque ------------------------------------------------------------ VPS15-1_Smoe --------------------------LS------------------------DYKVEELS VPS15-2_Smoe --------------------------LS------------------------DYKVEELS GK073_Glam --------------------------SA------------------------EAITE--- PIK3R4_Hsap --P-HSVHGIY--------------------------CSP-ADGNPILL----------- PIK3R4_Mmus --P-HSVHGIY--------------------------CSP-ADGNPILL----------- CG9746_Dmel --P-ATTCGIL--------------------------SGV-VDGSPFIL----------- ZK930.1_Cele ARKQDS-LATRS-------------------------LCV-CEKTGVVY----------- VPS15_Scer ----RSLNALS--------------------------TI-SVSNDKILL----------- Vps15_Ddis FKPTPLVRALL----------------------------N-PPNCPFLI----------- 15015_Tthe ------------------------------------------------------------ VPS15_Spur ----HAIHALY--------------------------CIPSMEQTPCFL----------- CC1G_08691_Ccin APPAPDVRAMVVGLDFGGYASAHRLEYGEFIPDGGGASSR-SSTKGFVV----------- AqueK216_Aque ------------------------------------------------------------ VPS15-1_Smoe DPP-PRIPGVRA-------------------------LLP-TTAGASVI----------- VPS15-2_Smoe DPP-PRIPGVRA-------------------------LLP-TTAGASVI----------- GK073_Glam STAKPSVR---R-------------------------YY-AITSTLFIVAYGSHVVIYEF PIK3R4_Hsap -----------TAGSDMKIRFWDLAY-------------PERSYVVAGSTSSP------- PIK3R4_Mmus -----------TAGSDMKIRFWDLVS-------------PERSYVVAGSTGSP------- CG9746_Dmel -----------TGSSDQRIRYWDITN-------------PKNSSLKVPAANDNLA----- ZK930.1_Cele -----------TGDTRGAIRKWNPTR-------------AVGCEIISAPPKGRTAYRTIF VPS15_Scer -----------TDEATSSIVMFSLNE-------------LSSSKAVISPSR--------- Vps15_Ddis -----------TAGDDKRIKLWDWNN-------------LPQSYYVSIGKEPPPF----- 15015_Tthe ------------------------------------------------------------ VPS15_Spur -----------TAGSDQRIRYWNITN-------------PQQSSIIAGSVNDPVT----- CC1G_08691_Ccin -----------TGSDDRRLRFWDLSR-------------AEKSVVFSGLEQDGER----- AqueK216_Aque ------------------------------------------------------------ VPS15-1_Smoe -----------TGGTDCRIRLWDHLR-------------PETSYCICGPTVKNA------ VPS15-2_Smoe -----------TGGTDCRIRLWDHLR-------------PEASYCICGPTVKNA------ GK073_Glam DSKLENPVLQFVGGLDVRMSGHTKNRTKQQEKPAFSAITSHENSCILGLSNGAV------ PIK3R4_Hsap ----------------SVSYYRKIIEGTEVVQEIQNK-Q----------KVG-------- PIK3R4_Mmus ----------------SVSYYKKIIEGTEVVQEIQNK-Q----------KVG-------- CG9746_Dmel --------------DVAFNYGARLIDGSQVIEEQIISMA----------STGD------- ZK930.1_Cele EENDTSTAPSGASTDPFVIYER-TVLD----TEAKEN-Q--------------------- VPS15_Scer -------------------FSDV-FIPTQVTANL-------------------------- Vps15_Ddis ---------------YTHKFSNDTSNAYEIHEEVWHDTSSSSFYSNSAMFGGGGGGQPMS 15015_Tthe -------------------------FDKRKTE--------------------K------- VPS15_Spur --------------QLSVSYNHRVIDGTEVIVETYGK-Q----------RGGT------- CC1G_08691_Ccin ---------------PTHSINSGGSRGGE---DEGNKGPVSYVETWPAVPTGG------- AqueK216_Aque ------------------------------------------------------------ VPS15-1_Smoe ---------------PPFRYSSKTVCGLHITQESMHE----------------------- VPS15-2_Smoe ---------------PPFRYSSKTVCGLHITQESMHE----------------------- GK073_Glam ---------------LMVNECEKEIISCKMLSSPNKY----------------------- PIK3R4_Hsap ----------------------------------PSDDTPRRGPESL------------- PIK3R4_Mmus ----------------------------------PSDDTPRRGPESL------------- CG9746_Dmel ----------------------------SQQLRSSTEENPRSGPDMP------------- ZK930.1_Cele -------------------------------------KVV-P-LDSK------------- VPS15_Scer -----------------------------TMLLRKMKRTS-THSVDD------------- Vps15_Ddis TSLSSSSLSQQQHQAQLQLQYQLQQQQQQQQYINHLQQQKSKTSISM------------- 15015_Tthe ----------------------------NTKLISHLEKID-MIERDE------------- VPS15_Spur ----------------------------GSAATSGSDESQRRSAEQV------------- CC1G_08691_Ccin ---QSS---------------------RP----SQRISLITQHQQNL------------- AqueK216_Aque ------------------------------------------------------------ VPS15-1_Smoe ---------------------------------NVQSEVA-LAAVDM------------- VPS15-2_Smoe ---------------------------------NVQSEVA-LAAVDM------------- GK073_Glam ---------------------------------RITSNID-LASTDTVTNNHKKFGVFFS PIK3R4_Hsap -----PVGHHDIITDVATFQTT-QGFIVTASRDGI-----VKVW-----K PIK3R4_Mmus -----PVGHHDIITDIATFQTT-QGFIVTASRDGI-----VKVW-----K CG9746_Dmel -----TASHHDAITDLLMCKDKGQIYIASASRNGV-----IKLW-----K ZK930.1_Cele ----PSTYHRTPITDMMLLN---SELLVSSGYDGV-----IKIWK----- VPS15_Scer -----SLYHHDIINSISTCEVDETPLLVACDNSGL-----IGIF-----Q Vps15_Ddis ----PTVHHQEPILDIKMMEVP-NPMLISASTDGV-----VKVW-----K 15015_Tthe -----G-FFKDCLDKFLQNKSKPQSEIDQRILECMIGLDDPNCN-----Y VPS15_Spur -----PVGHRDVITDMGVFQIS---------------------S-----S CC1G_08691_Ccin -----LKSHQDVVTALACIDSPWRGGIVSGDRAGV-----VKVWRLDYVE AqueK216_Aque ----------------------------SKKSKKS-----SKRI-----Q VPS15-1_Smoe -----AGCHRDSITSLAA---A-SQLLISSSRDGT-----IKVW-----K VPS15-2_Smoe -----AGCHRDSITSLAA---A-SQLLISSSRDGT-----IKVW-----K GK073_Glam NQPSGLVAHQGPVVAIK---SS-GHSVFSADTSGL-----ILFYH-----