CLUSTAL W (1.83) multiple sequence alignment Wnk4_Hsap MLASPATETTV--LMSQTEADLALRP-PPPLGT---AGQPR-----L------GPP---- Wnk3_Hsap MATDSGDPAST--EDSEKPDGISFEN-RVPQVAATLTVEAR-----LK------------ C46C2.1_Cele MTVICNRCRNISCRMSITNG--G-RP-PAPPSSVSSTTAST-----TG---NFGTR---- CG7177_Dmel MVLPPAPRN-----------------------LKGENTSIS-----SEEQTVQGANIQKS Wnk1_Mmus MSDGAAEKQS------GTPGF--LTP-PAPVPKNGSSSDSS-----VGE--KLGAT---- Wnk2_Mmus MDGDGGRRD-A--PGALMEAG------------RGT-GSA-------------------- Wnk3_Mmus MATDSGEPAST--EDSEKPDGVSFEN-RAARAVAPLTVEAR-----IK------------ Wnk4_Mmus MLAPRNTETGV--PMSQTEADLALRP-SPALTS---TGPTR-----L------GPP---- Wnk1_Hsap MSGGAAEKQS------STPGSLFLSP-PAPAPKNGSSSDSS-----VGE--KLGAA---- Wnk2_Hsap MDGDGGRRD-V--PGTLMEPG------------RGA-GPA-------------------- 17822_Tthe MMILKNRRIK-------------------------------------------------- 8961_Tthe SDYS-------------------------------------------------------- WNK_Spur MSKSESHNSGS--SLSNGVASLEERDTDVPLKSHSSESVTK-----QGS--K-G-K---- AqueK219_Aque MTTSTQGQAVI--PEEPT-TNNHLNE-AQPISHQSSSSLLSKGLLVVGD--KIFPG---- WNK_e_Smoe MCCVMEVES--------------------------------------------------- WNK_a_Smoe MPASKP------------------------------------------------------ WNK_d_Smoe MTDKKPED-------HP------------------------------------------- WNK_c_Smoe MTDKKPED-------HP------------------------------------------- WNK_b-2_Smoe MRTGDGCQAEA--QLHQ------------------------------------------- WNK_b-1_Smoe MRTGDGCQAEA--QLHQ------------------------------------------- GK075_Glam MEIVAPLS------------------------VF------------------AGT----- Wnk4_Hsap ------------------------------------------------------------ Wnk3_Hsap ------------------------------------------------------------ C46C2.1_Cele -RR-LVNRIKKVDE--------------------------------------LHPAQE-- CG7177_Dmel GHRSFNRSASSRQKPNPTSKLKDTLNRKPTCKQGTLSAHTSTSSTTSIQSSPIEPASSLP Wnk1_Mmus -V-------------------------------------------------------A-- Wnk2_Mmus ------------------------------------------------------------ Wnk3_Mmus ------------------------------------------------------------ Wnk4_Mmus ------------------------------------------------------------ Wnk1_Hsap -A-------------------------------------------------------A-- Wnk2_Hsap ------------------------------------------------------------ 17822_Tthe ------------------------------------------------------------ 8961_Tthe ------------------------------------------------------------ WNK_Spur -S-------------------------------------------------------G-- AqueK219_Aque -P-------------------------------------------------------A-- WNK_e_Smoe ------------------------------------------------------------ WNK_a_Smoe ------------------------------------------------------------ WNK_d_Smoe ------------------------------------------------------------ WNK_c_Smoe ------------------------------------------------------------ WNK_b-2_Smoe ------------------------------------------------------------ WNK_b-1_Smoe ------------------------------------------------------------ GK075_Glam -----------QNQP--------------------------------------------- Wnk4_Hsap ------------------------------------------------------------ Wnk3_Hsap ------------------------------------------------------------ C46C2.1_Cele ------NPTM---------------GSHWLS----------------------------- CG7177_Dmel TLNTTPTPPAASKSNLFVRVLRRFSN---NTLPGKTASSPKNVDDVPKVNDNNNGDLGKQ Wnk1_Mmus ------DSGV---------------G---RT----------------------------- Wnk2_Mmus -------------------------G---MA----------------------------- Wnk3_Mmus ------------------------------------------------------------ Wnk4_Mmus ------------------------------------------------------------ Wnk1_Hsap ------DAVT---------------G---RT----------------------------- Wnk2_Hsap -------------------------G---MA----------------------------- 17822_Tthe ------------------------------------------------------------ 8961_Tthe ------------------------------------------------------------ WNK_Spur ------DTQT---------------E---EA----------------------------- AqueK219_Aque ------DVSS---------------L---AK----------------------------- WNK_e_Smoe ------------------------------------------------------------ WNK_a_Smoe ------------------------------------------------------------ WNK_d_Smoe ------------------------------------------------------------ WNK_c_Smoe ------------------------------------------------------------ WNK_b-2_Smoe ------------------------------------------------------------ WNK_b-1_Smoe ------------------------------------------------------------ GK075_Glam ------YPE--------------------------------------------------- Wnk4_Hsap ------------PRRAR------------------------------------------- Wnk3_Hsap -----------------------------------------------EKNS--------- C46C2.1_Cele ----------EQERSRLEA---------------------------VQQDWRR------- CG7177_Dmel QSTDVEVLCSQDNQSREQNEDEMDSKIEPADAISNQKAGLTSGKPKKDKSVKGTSQAVVS Wnk1_Mmus ----------EEYRRRRHT---------------------------MDKDS--------- Wnk2_Mmus ----------E---------------------------------------P--------- Wnk3_Mmus -----------------------------------------------EKYS--------- Wnk4_Mmus ------------PRRVR------------------------------------------- Wnk1_Hsap ----------EEYRRRRHT---------------------------MDKDS--------- Wnk2_Hsap ----------E---------------------------------------P--------- 17822_Tthe ------------------------------------------------------------ 8961_Tthe ------------------------------------------------------------ WNK_Spur ----------EAADA--------------------------------------------- AqueK219_Aque ----------EDEQSGTHNL--------------------------PDVET--------- WNK_e_Smoe ------------------------------------------------------------ WNK_a_Smoe ------------------------------------------------------------ WNK_d_Smoe ------------------------------------------------------------ WNK_c_Smoe ------------------------------------------------------------ WNK_b-2_Smoe ------------------------------------------------------------ WNK_b-1_Smoe ------------------------------------------------------------ GK075_Glam ------------------------------------------------------------ Wnk4_Hsap ---------R-------------FS----------GKAEPRP--RSSRLSRRSSVDLG-- Wnk3_Hsap ---------T-------------FS----------ASG-ETV--ERKRFFRKSVEMTE-- C46C2.1_Cele -------TRP-------------MK----------WTSKKRP--DDPTTSSPSTVSISNA CG7177_Dmel DTKKMEARKSSSDTVIEPLIKQQAPLHSSKTTPTTLTA-NFV--QNIRFVRKNVEQSG-- Wnk1_Mmus ---------R-------------GA----------A-ATTTP--TEHRFFRRSVICDS-- Wnk2_Mmus ---------R-------------AR-------------AARL--GPQRFLRRSVVESD-- Wnk3_Mmus ---------T-------------FS----------ASG-ENI--ERKRFFRKSVEMTE-- Wnk4_Mmus ---------R-------------FS----------GKAEPRP--RSSRPSRRSSVDLG-- Wnk1_Hsap ---------R-------------GA----------A-ATTTT--TEHRFFRRSVICDS-- Wnk2_Hsap ---------R-------------AK-------------AARP--GPQRFLRRSVVESD-- 17822_Tthe ------------------------------------------------------------ 8961_Tthe ------------------------------------------------------------ WNK_Spur ---------------------------------------SHSGVNGESSMGNSVV-ISNR AqueK219_Aque ---------M-------------GS-------------SS----------RPNGVIIENG WNK_e_Smoe ------------------------------------------------------------ WNK_a_Smoe ------------------------------------------------------------ WNK_d_Smoe -------------------------------------QE--------------------- WNK_c_Smoe -------------------------------------QE--------------------- WNK_b-2_Smoe -------------------------------------CENR---SRSRFL---------- WNK_b-1_Smoe -------------------------------------CENR---SRSRFL---------- GK075_Glam -----------------------VE----------------------------------- Wnk4_Hsap ---------LLS-SWSLPASP-A-----------------------PDPPDPP------- Wnk3_Hsap ---------DDK-VA----------------------------------ESSPKDERIKA C46C2.1_Cele LENSTPSLNNVS-SITNSSSP-FSL----SSAATSTASAIIPFTSNVATNHPHLNHH-VS CG7177_Dmel ---------RNTNPLQFVELE-TEFPRDY------------------------DDNI-EM Wnk1_Mmus ---------NAT-ALELPGLP-LSIPQPSVPA-------VVP---QSAPPEPHREET-LT Wnk2_Mmus ---------QEE----PPGLE---------AA-------ETP---SAQPPQPLQRRV-LL Wnk3_Mmus ---------DDK-VA----------------------------------ESSRRDER-KA Wnk4_Mmus ---------LLS-SWSQPASL-L-----------------------PEPPDPP------- Wnk1_Hsap ---------NAT-ALELPGLP-LSLPQPSIPA-------AVP---QSAPPEPHREET-VT Wnk2_Hsap ---------QEE----PPGLE---------AA-------EAP---GPQPPQPLQRRV-LL 17822_Tthe ------------------------------------------------------------ 8961_Tthe ------------------------------------------------------------ WNK_Spur R------------------SPNFSD-----------------TDVNVESFHN-------- AqueK219_Aque GETNVHFVS---------------------------------SKEEVLPTEPEKQK---- WNK_e_Smoe ------------------------------------------------------------ WNK_a_Smoe ------------------------------------------------------------ WNK_d_Smoe ------------------------------------------------------------ WNK_c_Smoe ------------------------------------------------------------ WNK_b-2_Smoe ------------------------------------------------------------ WNK_b-1_Smoe ------------------------------------------------------------ GK075_Glam ------------------------------------------------------------ Wnk4_Hsap -------------------------------------DSAGPGPA--RSPPPS------- Wnk3_Hsap AMNI----PR-------------VDKLPSN-VLRGGQ----------------------- C46C2.1_Cele RIPQ----AIVTGGTNGSLPPLLISPTSAAAATPLISGKAGPMSP--STGSPINVAATVL CG7177_Dmel LSREAEHLEE-------------QFRTPTRS----------------------------- Wnk1_Mmus ATVA----SQ-------------VSQQPSAAASPGEQAVVGSATT--TVPSST------- Wnk2_Mmus LCKTRRLIAE-------------RARGRPAAPAPAAP-AAPPGSP--SVPSDP------- Wnk3_Mmus ATNI----SR-------------VDKVPTN-VLRGGQ----------------------- Wnk4_Mmus -------------------------------------DSAG--PT--RSPPSS------- Wnk1_Hsap ATAT----SQ-------------VAQQPPAAAAPGEQAVAGPAPS--TVPSST------- Wnk2_Hsap LCKTRRLIAE-------------RARGRPAAPAPAAL-VAQPGAP--GAPADA------- 17822_Tthe ------------------------------------------------------------ 8961_Tthe ------------------------------------------------------------ WNK_Spur --------DK-------------VTENSES-AADTKHTVISDESS--TTGYSS--RLDSI AqueK219_Aque -------------------------------------QDGGPVGGGVTPPI--QDSQDGV WNK_e_Smoe ------------------------------------------------------------ WNK_a_Smoe ------------------------------------------------------------ WNK_d_Smoe ------------------------------------------------------------ WNK_c_Smoe ------------------------------------------------------------ WNK_b-2_Smoe ------------------------------------------------------------ WNK_b-1_Smoe ------------------------------------------------------------ GK075_Glam ------------------------------------------------------------ Wnk4_Hsap ----------------------------------------------------------SK Wnk3_Hsap ------------------------------------------------------------ C46C2.1_Cele QNAVSSPQHS-----------------------------------------IFDRSRLNK CG7177_Dmel ---------NATDATSHHVAGIIDNIITEASRSLTIEKTEDDVPLKSSTKHS-------- Wnk1_Mmus ----------------------------------------------------------SK Wnk2_Mmus ----------------------------------------------------------GP Wnk3_Mmus ------------------------------------------------------------ Wnk4_Mmus ----------------------------------------------------------SK Wnk1_Hsap ----------------------------------------------------------SK Wnk2_Hsap ----------------------------------------------------------GP 17822_Tthe ------------------------------------------------------------ 8961_Tthe ------------------------------------------------------------ WNK_Spur G-------D---------------------------------------------KELLKE AqueK219_Aque K-------KK-----------------------------------------VLETLEVEE WNK_e_Smoe ------------------------------------------------------------ WNK_a_Smoe ------------------------------------------------------------ WNK_d_Smoe ------------------------------------------------------------ WNK_c_Smoe ------------------------------------------------------------ WNK_b-2_Smoe ------------------------------------------------------------ WNK_b-1_Smoe ------------------------------------------------------------ GK075_Glam ------------------------------------------------------------ Wnk4_Hsap EPPE------GTW-TEGAPVKAA------------------------------------E Wnk3_Hsap ------------------EVKY-------------------------------------- C46C2.1_Cele IPPN------TSLASSSSPSDAA---NNDKPIQQRHS-----ILSNVRTLTQAMVNDGPR CG7177_Dmel --S-------GVK---------------------RVGFQVEDK----------------- Wnk1_Mmus DRPV------S----QPSLVGS-------------------------------------K Wnk2_Mmus ERAG-------TQEPSPDPTTAS---AAAAQV----------------------PDGGPR Wnk3_Mmus ------------------EVKY-------------------------------------- Wnk4_Mmus EPPE------GTW-MGAAPVKAV------------------------------------- Wnk1_Hsap DRPV------S----QPSLVGS-------------------------------------K Wnk2_Hsap EPVG-------TQEPGPDPIAAA---VETAPA----------------------PDGGPR 17822_Tthe ------------------------------------------------------------ 8961_Tthe ------------------------------------------------------------ WNK_Spur KVPDTSVHLANSH-PNGTALKSARKDSNMKPERGRIA-------------------SGNG AqueK219_Aque HIV-------NTS-PTGRFVKYE---Q---EI-GRGSFKTVYKG---------------- WNK_e_Smoe ------------------------------------------------------------ WNK_a_Smoe ------------------------------------------------------------ WNK_d_Smoe ------------------------------------------------------------ WNK_c_Smoe ------------------------------------------------------------ WNK_b-2_Smoe ------------------------------------------------------------ WNK_b-1_Smoe ------------------------------------------------------------ GK075_Glam ------------------------------------------------------------ Wnk4_Hsap ------DSARPELPDSAVG------PGSREPLRVP---EAVALER----RREQ------- Wnk3_Hsap -----------------EQ--------CSK--STS---EISKDCFK--EKNEK------- C46C2.1_Cele -----------TLT--GDD------M--DK--MVS----EEERARK--EQEKREEEEKA- CG7177_Dmel --------------------------DDTE--VQSEKQAKS-----FDDITKKAESSEAS Wnk1_Mmus ------EEPPPSRS--GSG------SGGA----SA---KEAQEDR----SQQQ------- Wnk2_Mmus ------QEEAPAPTQEDA--------GTTE--AKP----EPGRARK--DEPEE------- Wnk3_Mmus -----------------EQ--------CSK--ATS---ESSKDCFK--EKTEK------- Wnk4_Mmus ------DSACPELTGSSGG------PGSREPPRVP---DAAARER----RREQ------- Wnk1_Hsap ------EEPPPARS--GSG------GG------SA---KEPQEER----SQQQ------- Wnk2_Hsap ------EEAAATVRKEDE--------GAAE--AKP----EPGRTRR--DEPEE------- 17822_Tthe -------------------------------------------------SLKKV------ 8961_Tthe -------------------------------------------------DRDE------- WNK_Spur KKQKSVVIMAPVKDITENGHIEVHKEEKVEPLQIH---EMHDSERRLLIETEE------- AqueK219_Aque ---------LDTE----TG------VAVAW--CEL---LDSQDGI----KKKV------- WNK_e_Smoe ---------------------------------------------------GA------- WNK_a_Smoe ------------------------------------------------------------ WNK_d_Smoe -------------------------------------------ARN--ESKSG------- WNK_c_Smoe -------------------------------------------ARN--ESKSG------- WNK_b-2_Smoe ------------------------------------------ASRM---SSQL------- WNK_b-1_Smoe ------------------------------------------ASRM---SSQL------- GK075_Glam ------------------------------------------------------------ Wnk4_Hsap -----------------------------------EEKEDMETQAVA------------- Wnk3_Hsap -----------------------------------EMEEEAEMKAVA------------- C46C2.1_Cele -----------------------------ARRIDVEDDFDAQEKPID------------- CG7177_Dmel AEEAAVTGSSTDASASPLPSTSLVSTTSSATS-ITKSKSDEDDDPVA------------- Wnk1_Mmus -----------------------------------DDIEELETKAVG------------- Wnk2_Mmus -----------------------------------EEDDEDDLKAVA------------- Wnk3_Mmus -----------------------------------EMEEEAEMKAVA------------- Wnk4_Mmus -----------------------------------EEKEDTETQAVA------------- Wnk1_Hsap -----------------------------------DDIEELETKAVG------------- Wnk2_Hsap -----------------------------------EEDDEDDLKAVA------------- 17822_Tthe -----------------------------------LKEDLFEQELVQYYYWKIFIFKAIV 8961_Tthe -----------------------------------NEDNDYKDRIAE------------- WNK_Spur -----------------------------------AEPEAVEEKAIA------------- AqueK219_Aque -----------------------------------LETLEVEEHIVN------------- WNK_e_Smoe -----------------------------------NAADADDSEFVE------------- WNK_a_Smoe -----------------------------------GAESDTGSEFVE------------- WNK_d_Smoe -----------------------------------KEGEDEEAEFVE------------- WNK_c_Smoe -----------------------------------KEGEDEEAEFVE------------- WNK_b-2_Smoe -----------------------------------DLGSEDEAEFVE------------- WNK_b-1_Smoe -----------------------------------DLGSEDEAEFVE------------- GK075_Glam -----------------------------SSP-LRNEGVYYNPFSDT------------- Wnk4_Hsap -----------------TSPDGRYLKFDI-EIGRGSFKTVYRGLDTDTTVEVAWCELQTR Wnk3_Hsap -----------------TSPSGRFLKFDI-ELGRGAFKTVYKGLDTETWVEVAWCELQDR C46C2.1_Cele -----------------KSKNGRFLKFDE-ELGRGSFKTVFRGLDTETGVAVAWCELQES CG7177_Dmel -----------------MSPCGRFFKYDK-EVGRGSFKTVYRGLDTLTGVPVAWCELLDK Wnk1_Mmus -----------------MSNDGRFLKFDI-EIGRGSFKTVYKGLDTETTVEVAWCELQDR Wnk2_Mmus -----------------TSLDGRFLKFDI-ELGRGSFKTVYKGLDTETWVEVAWCELQDR Wnk3_Mmus -----------------TSPSGRFLKFDI-ELGRGAFKTVYKGLDTETWVEVAWCELQDR Wnk4_Mmus -----------------TSPDGRYLKFDI-EIGRGSFKTVYRGLDTDTTVEVAWCELQTR Wnk1_Hsap -----------------MSNDGRFLKFDI-EIGRGSFKTVYKGLDTETTVEVAWCELQDR Wnk2_Hsap -----------------TSLDGRFLKFDI-ELGRGSFKTVYKGLDTETWVEVAWCELQDR 17822_Tthe SCHYSFISTKFHQNTNQIFLQIIKIKFNE-ELGFGAYKTVYKGYDNDSGCEIAWNVIKLQ 8961_Tthe -----------------TSPKGRFIRFNE-ELGFGAYKTVYRAYDNDSGCEVAWNVIKLQ WNK_Spur -----------------KSADGRFMKYDV-AVGQGSFKTVFRGLDTETGVAVAWCELQER AqueK219_Aque -----------------TSPTGRFVKYEQ-EIGRGSFKTVYKGLDTETGVAVAWCELLEH WNK_e_Smoe -----------------VDPTGRYGRYNE-VLGRGAFKTVYKAFDEVDGIEVAWNQVNVQ WNK_a_Smoe -----------------IDPTGRYGRYSE-VLGKGAFKAVYRAFDEVDGLEVAWNQVNVQ WNK_d_Smoe -----------------RDPTGRYGRYNE-ILGKGAFKTVYRAFDEVDGIEVAWNQVKVE WNK_c_Smoe -----------------RDPTGRYGRYNE-ILGKGAFKTVYRAFDEVDGIEVAWNQVKVE WNK_b-2_Smoe -----------------VDPTGRYGRYKE-LLGKGAFKTVYKAFDEIDGIEVAWNQVKLH WNK_b-1_Smoe -----------------VDPTGRYGRYKE-LLGKGAFKTVYKAFDEIDGIEVAWNQVKLH GK075_Glam -----------------LGPSDRYLKYSGDVLGKGAFKTVYRAFDLIAGREVAWNEVVLD ::. :* *::*:*::. * :** : Wnk4_Hsap KLS--RAERQRFSEEVEMLKGLQHPNIVRFYDSWKSVL--RGQVCIVLVTELMTSGTLKT Wnk3_Hsap KLT--KAEQQRFKEEAEMLKGLQHPNIVRFYDSWESIL--KGKKCIVLVTELMTSGTLKT C46C2.1_Cele KLN--KTERQRFREEAEMLKDLQHPNIVRFYDYWESADLCGKRKYIVLVTELMTSGTLKM CG7177_Dmel QVK--KSERTRFREEADMLKKLQHPNIVRFYTYWEFPI--GRKKNIVLVTELMLSGTLKS Wnk1_Mmus KLT--KSERQRFKEEAEMLKGLQHPNIVRFYDSWESTV--KGKKCIVLVTELMTSGTLKT Wnk2_Mmus KLT--KLERQRFKEEAEMLKGLQHPNIVRFYDFWESSA--KGKRCIVLVTELMTSGTLKT Wnk3_Mmus KLT--KAEQQRFKEEAEMLKGLQHPNIVRFYDSWESTL--KGKKCIVLVTELMTSGTLKT Wnk4_Mmus KLS--RAERQRFSEEVEMLKGLQHPNIVRFYDSWKSVL--RGQVCIVLVTELMTSGTLKT Wnk1_Hsap KLT--KSERQRFKEEAEMLKGLQHPNIVRFYDSWESTV--KGKKCIVLVTELMTSGTLKT Wnk2_Hsap KLT--KLERQRFKEEAEMLKGLQHPNIVRFYDFWESSA--KGKRCIVLVTELMTSGTLKT 17822_Tthe RLP--Q--------------------------------------------QCLSGGSLK- 8961_Tthe RLP--LNERKRISEEIQLLKNLHHPNIINFINAWINKS----KNEVIFITECVSGGSLKK WNK_Spur KLS--RSERQRFKEEAEMLKGLSHPNIVSFYDYWEEVSP-RGKKHIVLVTELMTSGTLKT AqueK219_Aque KFN--KEEQSRFKEEVAILKTLNHPYILRLFDSWEFVRQSDKKRVLVLITELMTSGTLKS WNK_e_Smoe DVLGRPEDLERLYSEVHLLRGLKHKNVIKFFTSWVDPR----TKNVNFITEIFTSGTLRQ WNK_a_Smoe DLLRSPDDLERLYSEVHLLKTLKHKNIIKFYTSWVDSK----RRNVNFITEIFTSGTLRQ WNK_d_Smoe DVLQSPEDLERLYSEVHLLKSLKHKNIIKLYNSWVDTK----TKNVNFITEIFTSGTLRQ WNK_c_Smoe DVLQSPEDLERLYSEVHLLKSLKHKNIIKLYNSWVDTK----TKNVNFITEIFTSGTLRQ WNK_b-2_Smoe DVLRSPEDLERLYSEVHLLKSLKHKNIIKFYNSWVDTK----NNNVNFITEIFTSGNLRQ WNK_b-1_Smoe DVLRSPEDLERLYSEVHLLKSLKHKNIIKFYNSWVDTT----SNNVNFITEIFTSGNLRQ GK075_Glam TLE--PMASSKLFQEIKALKDVDHENIIKLYDHWFE-----GSNLLIFTTELMPSGCLKK . : . .* *: Wnk4_Hsap YLRRFR-EMKPRV-LQRWSRQILRGLHFLHSRVP-PILHRDLKCDNVFITGPTGSVKIGD Wnk3_Hsap YLKRFK-VMKPKV-LRSWCRQILKGLQFLHTRTP-PIIHRDLKCDNIFITGPTGSVKIGD C46C2.1_Cele YLKRFK-RINIKVVLKSWCRQILKGLSFLHTRNP-PVIHRDLKCDNIFITGTTGSVKIGD CG7177_Dmel YLKRFK-KIHPKV-LKSWCRQILKGLNFLHTRQF-PIIHRDLKCDNIFITGTTGSVKIGD Wnk1_Mmus YLKRFK-VMKIKV-LRSWCRQILKGLQFLHTRTP-PIIHRDLKCDNIFITGPTGSVKIGD Wnk2_Mmus YLKRFK-VMKPKV-LRSWCRQILKGLLFLHTRTP-PIIHRDLKCDNIFITGPTGSVKIGD Wnk3_Mmus YLKRFK-VMKPKV-LRSWCRQILKGLQFLHTRTP-PIIHRDLKCDNIFITGPTGSVKIGD Wnk4_Mmus YLRRFR-EMKPRV-LQRWSRQILRGLHFLHSRVP-PILHRDLKCDNVFITGPSGSVKIGD Wnk1_Hsap YLKRFK-VMKIKV-LRSWCRQILKGLQFLHTRTP-PIIHRDLKCDNIFITGPTGSVKIGD Wnk2_Hsap YLKRFK-VMKPKV-LRSWCRQILKGLLFLHTRTP-PIIHRDLKCDNIFITGPTGSVKIGD 17822_Tthe ---KIK-KPRLKI-IKQWCKQILSGLQYLHEQEPHPIIHRDIKCENIFVNTVNNEIRIGD 8961_Tthe HLKKIK-KPRLKI-IKNWCRQILKGLVYLHEQKPYPIIHRDIKCENVFISTTNNEIRIGD WNK_Spur YLKRFK-GVKNRV-LRSWCRQILKGLHFLHTRQP-PIIHRDLKCDNIFITGTSGAVKIGD AqueK219_Aque YMRRFK-SIKPRV-IRSWGRQILRGLSFLHTRTP-PIIHRDLKCDNVFINGTTGLVKIGD WNK_e_Smoe YRKKHK-NVDMKA-VKNWARQILRGLLYLHSHDP-PIIHRDLKCDNIFVNGNQGEVKIGD WNK_a_Smoe YRKKHK-NVDMKA-VKNWARQILRGLLYLHSHDP-PIIHRDLKCDNIFVNGNYGEVKIGD WNK_d_Smoe YRKKHK-HVDMRA-VKNWAKQILRGLLYLHSHNP-PIIHRDLKCDNIFVNGNQGEVKIGD WNK_c_Smoe YRKKHK-HVDMRA-VKNWAKQILRGLLYLHSHNP-PIIHRDLKCDNIFVNGNQGEVKIGD WNK_b-2_Smoe YRRKHK-HVDLKA-VKHWARQILRGLLYLHSHDP-PIIHRDLKCDNIFVNGNHGEVKIGD WNK_b-1_Smoe YRRKHK-HVDLKA-VKHWARQILRGLLYLHSHDP-PIIHRDLKCDNIFVNGNHGEVKIGD GK075_Glam YLKKNPTALTTPV-LKSWALQILEALNYMHTCQP-KIIHRDIKAQNIFINGATGVVKVGD : :: * *** .* ::* ::***:*.:*:*:. . :::** Wnk4_Hsap LGLA-TL-KRASFAKSVIGTPEFMAPEMYE-EKYDEAVDVYAFGMCMLEMATSEYPYSEC Wnk3_Hsap LGLA-TL-MRTSFAKSVIGTPEFMAPEMYE-EHYDESVDVYAFGMCMLEMATSEYPYSEC C46C2.1_Cele LGLA-TL-KNKSFAKSVIGTPEFMAPEMYE-EMYDESVDVYAFGMCLLEMVTGEYPYSEC CG7177_Dmel LGLA-TL-KNRSHAKSVIGTPEFMAPEMYE-EHYDESVDVYAFGMCMLEMAISEYPYSEC Wnk1_Mmus LGLA-TL-KRASFAKSVIGTPEFMAPEMYE-EKYDESVDVYAFGMCMLEMATSEYPYSEC Wnk2_Mmus LGLA-TL-KRASFAKSVIGTPEFMAPEMYE-EHYDESVDVYAFGMCMLEMATSEYPYSEC Wnk3_Mmus LGLA-TL-MRTSFAKSVIGTPEFMAPEMYE-EHYDESVDVYAFGMCMLEMATSEYPYSEC Wnk4_Mmus LGLA-TL-KRASFAKSVIGTPEFMAPEMYE-EKYDEAVDVYAFGMCMLEMATSEYPYSEC Wnk1_Hsap LGLA-TL-KRASFAKSVIGTPEFMAPEMYE-EKYDESVDVYAFGMCMLEMATSEYPYSEC Wnk2_Hsap LGLA-TL-KRASFAKSVIGTPEFMAPEMYE-EHYDESVDVYAFGMCMLEMATSEYPYSEC 17822_Tthe LGLA-LT-LKSDFTTSVLGTPEFMAPEIYE-EKYGTAVDIYAFGMCLLEMATLQIPYREC 8961_Tthe LGLA-VSLKNSSHTKSVIGTPEFMAPEIYE-EKYGTPVDIYSFGMCVLEMATLSTPYKEC WNK_Spur LGLA-TL-KKSSFAKSVIGTPEFMAPEMYE-EHYDEAVDVYAFGMCLLEMATSEYPYAEC AqueK219_Aque LGLA-TL-KRS-DVKTVIGTPEFMAPEMYD-EVYDESVDVYAFGMCLLEMCTLEYPYQEC WNK_e_Smoe LGLA-TILRQAHAAHSVIGTPEFMAPELYE-EDYNELVDIYAFGMCVLELVTFDYPYSEC WNK_a_Smoe LGLA-TILRQAHAAHSVIGTPEFMAPELYE-EEYDELVDIYSFGMCVLEMVTFEYPYSEC WNK_d_Smoe LGLA-AILRQAHAAHSVIGTPEFMAPELYE-EEYNELVDIYSFGMCLLEMVTFEYPYSEC WNK_c_Smoe LGLA-AILRQAHAAHSVIGTPEFMAPELYE-EEYNELVDIYSFGMCLLEMVTFEYPYSEC WNK_b-2_Smoe LGLA-GILRQAHGAHSVIGTPEFMAPELYE-EDYNELVDIYSFGMCLLEMVTFEYPYSEC WNK_b-1_Smoe LGLA-GILRQAHGAHSVIGTPEFMAPELYE-EDYNELVDIYSFGMCLLEMVTFEYPYSEC GK075_Glam LGLCASL-GLQSTAVSCIGTPEFMAPETYSNAHYDEKVDIYAFGMLLLELITRDTPYLEC ***. . : :********* *. *. **:*:*** :**: . ** ** Wnk4_Hsap QNAAQIYRKVTSGRKPNSFHKV--KIPEVKEIIEGCIRTDKNERFTIQDLLAHAFFREER Wnk3_Hsap QNAAQIYRKVTSGIKPASFNKV--TDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAEDT C46C2.1_Cele MNPATIYRKVISGVKPECFSRIPAQYPEIREIIDRCIRVRREERSTVKQLLVDDFFTPED CG7177_Dmel KGPAQIYKKVISGIKPAALAKV--EDPNVRDIIERCIELKKEDRPSCNELLESEFFDEDI Wnk1_Mmus QNAAQIYRRVTSGVKPASFDKV--AIPEVKEIIEGCIRQNKDERYSIKDLLNHAFFQEET Wnk2_Mmus QNAAQIYRKVTCGIKPASFEKV--HDPEIKEIIGECICKNKEERYEIKDLLSHAFFAEDT Wnk3_Mmus QNAAQIYRKVTSGIKPASFNKV--TDPEVKEIIEGCIRQNKSERLSIKDLLNHAFFAEDT Wnk4_Mmus QNAAQIYRKVTSGTKPNSFYKV--KMPEVKEIIEGCIRTDKNERFTIQDLLAHAFFREER Wnk1_Hsap QNAAQIYRRVTSGVKPASFDKV--AIPEVKEIIEGCIRQNKDERYSIKDLLNHAFFQEET Wnk2_Hsap QNAAQIYRKVTCGIKPASFEKV--HDPEIKEIIGECICKNKEERYEIKDLLSHAFFAEDT 17822_Tthe TSAAQVYKKVSQGLLPNSLQLI--QNDSLKQFILKCIQR-SENRPSAAQLLQDDFFKESE 8961_Tthe TSAAQVYKKVSQGILPYQIDLI--QNEGLKNLILKCLSH-YKDRPSAEELLNDKFLDMSE WNK_Spur SNAAQIYRRVTTGVKPQSFEKV--NDNKIKEIIDGCTKTNNTERYLIQELLKHTFFED-T AqueK219_Aque SNPAQIYKKVTSGVMPNSLNKV--NDPMLKEIIVACTKLSKSARYTVEMLLNHEFFAEGD WNK_e_Smoe TNAAQIYKKVSSGIKPAALDKV--KDPEVRSFIQKCLAT-ASKRLPARELLKDPFLQCES WNK_a_Smoe TNAAQIYKRVTSGKKPAAFEKV--KDPEVRKFIEKCLAA-VSRRLPARELLMDPFLRCDG WNK_d_Smoe TNAAQIYKKVTSGKKPAALDRV--KDLEVRAFIEKCLAT-VSKRLPARELLMDPFLQSED WNK_c_Smoe TNAAQIYKKVTSGKKPAALDRV--KDLEVRAFIEKCLAT-VSKRLPARELLMDPFLQSED WNK_b-2_Smoe MNAAQIYKKVTSGKKPAALNKV--QDPQMRAFVEQCLAK-ACRRLPARELLMDPFLQCHT WNK_b-1_Smoe MNAAQIYKKVTSGKKPAALNKV--QDPQMRAFVEQCLAK-ACRRLPARELLMDPFLQCHT GK075_Glam ANIVDVLKKVEGNIPPNGLNKV--VHKEMKDLILLCINKDPSARPSARELLSKPFLSNMS . . : ::* . * : : :: :: * * ** *: Wnk4_Hsap --GVH---VELAEEDDG------------E------------------------------ Wnk3_Hsap --GLR---VELAEEDDC------------S------------------------------ C46C2.1_Cele LIGIR---VEIKNRDAD------------LNDL--------------------------- CG7177_Dmel --GIR---VEPTASEQF-----------LSDPS--------------------------- Wnk1_Mmus --GVR---VELAEEDDG------------E------------------------------ Wnk2_Mmus --GVR---VELAEEDHG------------R------------------------------ Wnk3_Mmus --GLR---VELAEEDDC------------S------------------------------ Wnk4_Mmus --GVH---VELAEEDDG------------E------------------------------ Wnk1_Hsap --GVR---VELAEEDDG------------E------------------------------ Wnk2_Hsap --GVR---VELAEEDHG------------R------------------------------ 17822_Tthe I---DNQPIQLASDR---------------IPQ--------------------------- 8961_Tthe Q-DEDNYPVQLLDAS---------------NAS--------------------------- WNK_Spur --AFR---VDIVHDDN-------------------------------------------- AqueK219_Aque ---VK---VEVMTEPTP------------AD----------------------------- WNK_e_Smoe D--RDGVADSLPSLNKD---------RVN---DMEEL---------PSRNPYSEFKDDTQ WNK_a_Smoe E---RESLE--------CIPVIRKQSRVD---DMEELRSSAVTNHE----SDQGDSDQQR WNK_d_Smoe R--EPLDPEQ-SQTDS-------------DQGGLGSYQKGV------------SFREEGK WNK_c_Smoe R--EPLELVP-PISRS--------TSRADDMEGLST------------------------ WNK_b-2_Smoe A--ERGVVHE-PHNSMDELEVILEEN---GDDSLSTIHAGAMAYDLAPRGAHHNHHELTR WNK_b-1_Smoe A--ERGVVHE-PHDSMDELEVILEEN---GDDSLSTIHAGAMAYDLAPRGAHHNHHELTR GK075_Glam --DTG-K-LTTDAKDHG-----------P-SAQ--------------------------- Wnk4_Hsap -------------K----------PGLKLWLRMEDA-------------R-RG-GRPRDN Wnk3_Hsap -------------N----------SSLALRLWVEDP-------------KKLK-GKHKDN C46C2.1_Cele -------------N----------VEIQMQLRVYDE-------------KKRKQYRFKEN CG7177_Dmel -------------I----------SIIEFRLRFMDP-------------KKRS-SRHKEN Wnk1_Mmus -------------K----------IAIKLWLRIEDI-------------KKLK-GKYKDN Wnk2_Mmus -------------K----------STIALRLWVEDP-------------KKLK-GKPKDN Wnk3_Mmus -------------N----------SSLALRLWVEDP-------------KKLK-GKHKDN Wnk4_Mmus -------------K----------PGLKLWLRMEDA-------------R-RG-GRPRDN Wnk1_Hsap -------------K----------IAIKLWLRIEDI-------------KKLK-GKYKDN Wnk2_Hsap -------------K----------STIALRLWVEDP-------------KKLK-GKPKDN 17822_Tthe ------SLGNSNDS---------------------P--------------Q-------TN 8961_Tthe ------------------------------------------------------------ WNK_Spur -------------K----------DQIQLQLRVEDP-------------KKRR-ERHRDN AqueK219_Aque -------------------------SVMVRLVVPRT-------------SK-E-NKKNEQ WNK_e_Smoe KSKDFKVKGKLRQ-----------DNIFLRLRISEQ--------------G-------HV WNK_a_Smoe KSIDFKVKGRRRED----------DTIFLRLRIADP-------------EG-------HI WNK_d_Smoe RSRDFRVKGKKKDD----------DTIFLRVRIADL-------------EG-------HV WNK_c_Smoe ------------------------------------------------------------ WNK_b-2_Smoe RSRDFRVRVRRRND----------DTIFLKLRIADQ-------------EG-------CI WNK_b-1_Smoe RSRDFRVRVRRRND----------DTIFLKLRIADQ-------------EG-------CI GK075_Glam -------------VSLGTHEQTMQSTGHTAVNAAQTALKLPQQSSLPISSPRG-PQQSH- Wnk4_Hsap QAIEFLFQLGRDAAEEVAQEMVALGL-------------------------VCE--ADYQ Wnk3_Hsap EAIEFSFNLETDTPEEVAYEMVKSGF-------------------------FHE--SDSK C46C2.1_Cele EGLQFAFDIENDSPDEVVQQMIEQQH-------------------------IPD--EDTR CG7177_Dmel EAIQFEYNIRHDEYEQIAQEMMKENI-------------------------ISE--DDSR Wnk1_Mmus EAIEFSFDLERDVPEDVAQEMVESGY-------------------------VCE--GDHK Wnk2_Mmus GAIEFTFDLEKETPDEVAQEMIDSGF-------------------------FHE--SDVK Wnk3_Mmus EAIEFSFNLEADTPEEVAYEMVKSGF-------------------------FHE--SDSK Wnk4_Mmus QAIEFLFQLGRDAAEEVAQEMVALGL-------------------------VCE--ADYQ Wnk1_Hsap EAIEFSFDLERDVPEDVAQEMVESGY-------------------------VCE--GDHK Wnk2_Hsap GAIEFTFDLEKETPDEVAQEMIESGF-------------------------FHE--SDVK 17822_Tthe H-QQQSFQQNQDQHSQVQSSNFKKTS-------------------------DFE--SPIH 8961_Tthe --TPMNYTLSNSCPLESAQVFQLKGQKNTEASPCTDQNQNNEIQSQEIHSDNLK--DNMF WNK_Spur EALQFEIDLNKDEPDQVAKEMVRIGF-------------------------VSE--EDSK AqueK219_Aque ESIEFAYNLQTDIPEDIVNDMVKSGI-------------------------LRE--EDKK WNK_e_Smoe RNIHFAFDLEADTAFSVASEMVTELD-------------------------LSD--QDVA WNK_a_Smoe RNIHFPFDVEGDTALSVASEMVAELD-------------------------LSD--QDVT WNK_d_Smoe RNIHFPFSIEGDTAMSVASEMVAELD-------------------------LSD--QDVT WNK_c_Smoe ------------------------------------------------------------ WNK_b-2_Smoe RNIHFPFDVEADTALCVASEMVAELD-------------------------LSD--QDVT WNK_b-1_Smoe RNIHFPFDVEADTALCVASEMVAELD-------------------------LSD--QDVT GK075_Glam ----IPQSL--SKPVCPASMGVSVVN-------------------------VAVPTTAVT Wnk4_Hsap PVARAVRE----RVAAIQRK----RE---KLR-KAR----ELEALPP------E------ Wnk3_Hsap AVAKSIRD----RVTPIKKT----RE---KKP-AG-----CLEERRD------SQCKSM- C46C2.1_Cele MITKLIKD----KVDAFRRD----RD---HRL-LEIKRAKEEEERIR-------EEAEIK CG7177_Dmel AVARLLKV----QVVSLLKE----RA---QRQ-TQIKL---QNEKSR------LEKLALQ Wnk1_Mmus TMAKAIKD----RVSLIKRK----RE---QRQ-LVR----EEQEKRK------QEESSFK Wnk2_Mmus IVAKSIRD----RVALIQWR----RE---RIW-PAL----QSQEPKD------SGSPDKA Wnk3_Mmus AVAKSIRD----RVTLIKKI----RE---KKP-AG-----CLEERRD------SQCKYV- Wnk4_Mmus PVARAVRE----RVAAIQRK----RE---KLR-KAR----ELEVLPP------D------ Wnk1_Hsap TMAKAIKD----RVSLIKRK----RE---QRQ-LVR----EEQEKKK------QEESSLK Wnk2_Hsap IVAKSIRD----RVALIQWR----RE---RIW-PAL----QPKEQQD------VGSPDKA 17822_Tthe QVSQKQDNNSSSSASKSSHS----KQHRGSNQAS----------------P-AQSQNS-S 8961_Tthe -IPRKQSNFSDKKTTSLSHK----KK---KNQLTI-----DVTEYDFDEVN-KQQQLALQ WNK_Spur AVTKVIRD----RIGTVWKN----RE---KRE-KER----QEKGKLE------EDKDSKA AqueK219_Aque NAIRSVRE----LTDPLTDPAKQKRQ---QKP-A-A----TAGATAP------HG----- WNK_e_Smoe TIAEMIDA----EILSLVPD----WK---P---GG-----AFDADDEKG---VEDTGPV- WNK_a_Smoe TIAEMIDA----EILNLVPD----WK---P---GA-----AFDESGGDGENNYIDGDDM- WNK_d_Smoe TIAEMIDA----AIVALVPD----WR---P---GA-----SFEDNGVTE---VDDQAQA- WNK_c_Smoe ------------------------------------------------------------ WNK_b-2_Smoe TIADMIDA----EIVLLVPH----WR---P---GA-----SFEEHREDTI--LHDTDDI- WNK_b-1_Smoe TIADMIDA----EIVLLVPH----WR---P---GA-----SFEEHREDTT--LHDTDDI- GK075_Glam ---------------NSLSH----VL---ASE--TVST---DQSGSI------L------ Wnk4_Hsap ---PGPPPA---------------TVPMAPG--P---PSVFPPEPEEPEADQH------- Wnk3_Hsap -GNVFPQPQ-------------NTTLPLA----P---AQQTGAECEETEVDQH------- C46C2.1_Cele E--ELRLRAEAKEKEKERLEKERLEKKAAAAAAANPNPTPIPPTPATPHSSAQ------- CG7177_Dmel K--QRE------------------SLP----TN----VDEDEEEEEESEDEEDGVKWNQR Wnk1_Mmus Q--QNEQQASVSQAGIQQLSAASTGIPTAPATSA---SVSTQVEPEEPEADQH------- Wnk2_Mmus RGLPAPLQV-------------QVTYH----AQS---GQPGQPEPEEPEADQH------- Wnk3_Mmus -RNVLPQQQ-------------TATLQPT----P---GPHTAAEYEETEVDQH------- Wnk4_Mmus ---SGPPPA---------------TVSLAPG--P---PSAFPPEPEEPEADQH------- Wnk1_Hsap Q--QVEQS-SASQTGIKQLPSASTGIPTASTTSA---SVSTQVEPEEPEADQH------- Wnk2_Hsap RGPPVPLQV-------------QVTYH----AQA---GQPGPPEPEEPEADQH------- 17822_Tthe Q---------------------------------------SSEKPAQQNLTQN------- 8961_Tthe Q---------------------------------------QQEKQIQQDLVQV------- WNK_Spur -----DAGTSTTDSGMGFSGLSLTGMSNASEGSTR--LVSSQVQN----SSST------- AqueK219_Aque -NP------------------------PVPGNGAAG--------KETGEGLSH------- WNK_e_Smoe ------------------------------------------A----------------- WNK_a_Smoe ------------------------------------------K----------------- WNK_d_Smoe -----------------------------------------REES--------------- WNK_c_Smoe ------------------------------------------------------------ WNK_b-2_Smoe ------------------------------------------D----------------- WNK_b-1_Smoe ------------------------------------------D----------------- GK075_Glam ------------------------------------------------------------ Wnk4_Hsap ------------------------------------------------------------ Wnk3_Hsap ------------------------------------------------------------ C46C2.1_Cele ------------------------------------------------------------ CG7177_Dmel LQLRYDLLNTDSETSLALSTNSVEPQQLSTRSNTSIPNSGIQQPVQVPGQVPVSQLISVQ Wnk1_Mmus ------------------------------------------------------------ Wnk2_Mmus ------------------------------------------------------------ Wnk3_Mmus ------------------------------------------------------------ Wnk4_Mmus ------------------------------------------------------------ Wnk1_Hsap ------------------------------------------------------------ Wnk2_Hsap ------------------------------------------------------------ 17822_Tthe ------------------------------------------------------------ 8961_Tthe ------------------------------------------------------------ WNK_Spur ------------------------------------------------------------ AqueK219_Aque ------------------------------------------------------------ WNK_e_Smoe ------------------------------------------------------------ WNK_a_Smoe ------------------------------------------------------------ WNK_d_Smoe ------------------------------------------------------------ WNK_c_Smoe ------------------------------------------------------------ WNK_b-2_Smoe ------------------------------------------------------------ WNK_b-1_Smoe ------------------------------------------------------------ GK075_Glam ------------------------------------------------------------ Wnk4_Hsap -------QPFLFRH-----------ASYSSTTSDCETDGYLSSSGFL--DASDP------ Wnk3_Hsap -------VRQQLLQRKP-------QQHCSSVTGDNLSEAGAASVIHS--DT--SSQPSVA C46C2.1_Cele -------QQPIPPP-----------LSTQTSAE--------------------------- CG7177_Dmel PQAIPSPAIPMQQK-----------PTV-HYIQPPQLASYQNSNASM--QEMTNNQVISP Wnk1_Mmus -------QQLQYQQ-----------PSI-SVLSDGTIDSGQGSSVFT--ESRVSSQQTVS Wnk2_Mmus -------LLPPTLP-----------ASVTSLASDSTFDSGQGSTVYS--DSQ-SSQQSMV Wnk3_Mmus -------VRQQFLQGKP-------QQQSSSVRGDTSSEPTAGPVLHS--DT--SSHPTVA Wnk4_Mmus -------QSFLFRH-----------ASYSSTTSDCETDGYLSSSGFL--DASDP------ Wnk1_Hsap -------QQLQYQQ-----------PSI-SVLSDGTVDSGQGSSVFT--ESRVSSQQTVS Wnk2_Hsap -------LLPPTLP-----------TSATSLASDSTFDSGQGSTVYS--DSQ-SSQQSVM 17822_Tthe -------QSSIPKHESQNSLSSIGQNQTNSVQSSFHDQDANSKKLLT--TT--DGLTS-K 8961_Tthe -------NENIFVQVS-NTTSLVH--QSDSLETDSNYKTPQNQRNKSRMNT--FNSQSIS WNK_Spur -------QQPISQQ-----------PH-------------------S--QSQIQQQQVPS AqueK219_Aque -------QLL----------------------SNETTPTPQEIE-LS--ANRANFQRQLS WNK_e_Smoe ------------------------------------------------------------ WNK_a_Smoe ------------------------------------------------------------ WNK_d_Smoe --------------------------------------------------------PS-- WNK_c_Smoe ------------------------------------------------------------ WNK_b-2_Smoe ------------------------------------------------------------ WNK_b-1_Smoe ------------------------------------------------------------ GK075_Glam ------------------------------------------------------------ Wnk4_Hsap ------------------------------------------------------------ Wnk3_Hsap YSSNQTMGSQMV---SNI----PQAEVNVPG------QIYSSQQLVGHY----QQVS--- C46C2.1_Cele ------------------------------------------------------------ CG7177_Dmel TGSQQMQQQQPV---------------------------------------------VAP Wnk1_Mmus YGSQHEQAHSTG---------------------------------------------TAP Wnk2_Mmus LSSLVDTAPTPA---SCV----CSPPVSEGP------GLTHSLPTLGAF----QQPATVP Wnk3_Mmus YSSNQTTSSQVF---SSI----LQAYISVPE------QIHSSYQLLGYGIYLFSFIY--- Wnk4_Mmus ------------------------------------------------------------ Wnk1_Hsap YGSQHEQAHSTG---------------------------------------------TVP Wnk2_Hsap LGSLADAAPSPA---QCV----CSPPVSEGP------VLPQSLPSLGAY----QQPTAAP 17822_Tthe NGQNDSNMEQSI---TQIPSEE--RQVKVNK------Q--QSSE---------------- 8961_Tthe IQNNQSIQINTMTNNTSVVNQSTSNQVELNE------SIQSTSERF-------------- WNK_Spur HPQQTQQPSSQQ---------------------------------------------SVA AqueK219_Aque SA---------------------------------------------------------- WNK_e_Smoe -------------------------------EAEELNATE-------------------- WNK_a_Smoe -------------------------------NLG--DATDNVSS---------------- WNK_d_Smoe -----------------------VAQVSVPEEVESPSAVDATSD---------------- WNK_c_Smoe ------------------------------------------------------------ WNK_b-2_Smoe -------------------------------TCE-------------------------- WNK_b-1_Smoe -------------------------------TCE-------------------------- GK075_Glam ------------------------------------------------------------ Wnk4_Hsap ------------------------------------------------------------ Wnk3_Hsap ------------------------------------------------------------ C46C2.1_Cele ------------------------------------------------------------ CG7177_Dmel TVNHQVMPQQQVNQQQQQPQMMQQIPQQVQ-VQQPQ--------------TVLPPQPHEQ Wnk1_Mmus ----------------------GHTVSSIQAQSQPH--------------GVYPPSS-MA Wnk2_Mmus ----------------------GLSVGPVPPPARPPLLQQHFPESSMSFTPVLPPPS-TP Wnk3_Mmus ------------------------------------------------------------ Wnk4_Mmus ------------------------------------------------------------ Wnk1_Hsap ----------------------GHIPSTVQAQSQPH--------------GVYPPSS-VA Wnk2_Hsap ----------------------GLPVGSVPAPACPPSLQQHFPDPAMSFAPVLPPPS-TP 17822_Tthe ------------------------------------------------------------ 8961_Tthe ------------------------------------------------------------ WNK_Spur ------------------------TPQVQQQQ---------------------------- AqueK219_Aque --------------------------------------------------------S-DE WNK_e_Smoe ------------------------------------------------------------ WNK_a_Smoe ------------------------------------------------------------ WNK_d_Smoe ------------------------------------------------------------ WNK_c_Smoe ------------------------------------------------------------ WNK_b-2_Smoe ------------------------------------------------------------ WNK_b-1_Smoe ------------------------------------------------------------ GK075_Glam ------------------------------------------------------------ Wnk4_Hsap ------------------------------------------------------------ Wnk3_Hsap ----------GLQKHS---KLTQPQILP-------------------------------- C46C2.1_Cele ---------------------------IQQ------------------------------ CG7177_Dmel QPQQQQQPLQQQLQ----QLMHTNVQAPDLTQ--QQQMAQQQAQQYFQQQQQQPQQAVNM Wnk1_Mmus QGQNQGQPSSS-LAGV---LSSQPIQHPQQQ-GIQPTVPSQQAVQY------------SL Wnk2_Mmus VPTGPSQPAPPVQQPL---PMAQPPTLPQVL-APQPMGTVQPVPSH------------LP Wnk3_Mmus ----------HLQEQP---KLTQSPVLP-------------------------------- Wnk4_Mmus ------------------------------------------------------------ Wnk1_Hsap QGQSQGQPSSSSLTGV---SSSQPIQHPQQQQGIQQTAPPQQTVQY------------SL Wnk2_Hsap MPTGPGQPAPPGQQPP---PLAQPTPLPQVL-APQPVVPLQPVPPH------------LP 17822_Tthe ----------------------------------------SYYDQA------------IP 8961_Tthe --------------------------------------NIQKAYQN------------FK WNK_Spur --GQPQQPQPPQQQQQPQQVQSQPVMQPPQS-VQQPLPPQVHSQTH------------SQ AqueK219_Aque MSSEPSGPKHTTDRTG---PSAQVNN---------------------------------- WNK_e_Smoe ------------------------------------------------------------ WNK_a_Smoe ------------------------------------------------------------ WNK_d_Smoe ------------------------------------------------------------ WNK_c_Smoe ------------------------------------------------------------ WNK_b-2_Smoe ------------------------------------------------------------ WNK_b-1_Smoe ------------------------------------------------------------ GK075_Glam ------------------------------------------------------------ Wnk4_Hsap ------------------------------------------------------------ Wnk3_Hsap ------------------------------------------------------------ C46C2.1_Cele -----------------S--AQQPSVPVTMIANIPAMS---------------------- CG7177_Dmel QQAY-AMQ------------------------------QAGQQQQLSQPLQIQQQIL--- Wnk1_Mmus PQAA-SSS---EGTTAQP--VSQP------------QVSAGTQLPVSQTVATVQGE---- Wnk2_Mmus PYLA-PTSQVVAPAQLKP--LQMPQPPLQPLAQVPPQM---PQMPVVPPITPLTGLDGLP Wnk3_Mmus ------------------------------------------------------------ Wnk4_Mmus ------------------------------------------------------------ Wnk1_Hsap SQTS-TSS---EATTAQP--VSQPQAP-----QVLPQVSAGKQLPVSQPVPTIQGE---- Wnk2_Hsap PYLA-PASQVGAPAQLKP--LQMPQAPLQPLAQVPPQM---PPIPVVPPITPLAGIDGLP 17822_Tthe NGLQ-NTKQYSKDSQT----------------------SQITQIEIKNKSQEVEDKINTP 8961_Tthe IFKQ-DQSELDTPV------------------------------DLRQISQKEQKITQQT WNK_Spur PQLVSQSSQQPSTTAVLPQQDQAQQQPMQPSAQQP-------------PISNVQQQ---- AqueK219_Aque -----------------------------------------------------TGVGGAG WNK_e_Smoe ------------------------------------------------------------ WNK_a_Smoe -----DGSH--------------------------------------------------- WNK_d_Smoe -----DETR--------------------------------------------------- WNK_c_Smoe ------------------------------------------------------------ WNK_b-2_Smoe ------------------------------------------------------------ WNK_b-1_Smoe ------------------------------------------------------------ GK075_Glam ------------------------------------------------------------ Wnk4_Hsap ------------------------------------------------------------ Wnk3_Hsap ------------------------------------------------------------ C46C2.1_Cele -------PTSAQ-P-------Q--PV--L--------------S-----PT--------- CG7177_Dmel --QQQQVAVSHQ-Q-------QIMQQ--Q--------------L------AQH-QLQQLQ Wnk1_Mmus ----PHIPVSTQ-P-------SVVPV--H--------------S------GAH-FLP--- Wnk2_Mmus Q-TLTDLPAANV-A-------PVPPPQYF--------------S------PAV-ILP--- Wnk3_Mmus ------------------------------------------------------------ Wnk4_Mmus ------------------------------------------------------------ Wnk1_Hsap ----PQIPVATQ-P-------SVVPV--H--------------S------GAH-FLP--- Wnk2_Hsap P-ALPDLPTATV-P-------PVPPPQYF--------------S------PAV-ILP--- 17822_Tthe S-QVQDLDSLNI-K-------ATPQITEK--------------S------NSDQVQN--- 8961_Tthe P-KGSDIFSINN-SQINSSNYDIPQFKNNNGFKFIQDQQVYEES------GNFSIAS--- WNK_Spur ----PTIPAQQQ-S-------QPQQI--Q--------------QQPPQQQ--Q-LQQHQI AqueK219_Aque GGVGSEGPSASNSP-------NVPHKITG--------------G------TAM-TTP--- WNK_e_Smoe ------------------------------------------------------------ WNK_a_Smoe ------------------------------------------------------------ WNK_d_Smoe ------------------------------------------------------------ WNK_c_Smoe ------------------------------------------------------------ WNK_b-2_Smoe ------------------------------------------------------------ WNK_b-1_Smoe ------------------------------------------------------------ GK075_Glam ------------------------------------------------------------ Wnk4_Hsap ------------------------------------------------------------ Wnk3_Hsap ------------------------------------------------------------ C46C2.1_Cele ------------------------S---AAVPVPTTM----------------------- CG7177_Dmel QQQLQQQQLQQQQQIQQQQLQQQQL---QQQQFVQQYAQ-------AMPQQQHQQLVTGS Wnk1_Mmus ----------------------------MGQPIPTSLLP-------QYPV---------S Wnk2_Mmus ------------------------S---LTTPLPT--SP-------ALPM---------Q Wnk3_Mmus ------------------------------------------------------------ Wnk4_Mmus ------------------------------------------------------------ Wnk1_Hsap ----------------------------VGQPLPTPLLP-------QYPV---------S Wnk2_Hsap ------------------------S---LAAPLPPA-SP-------ALPL---------Q 17822_Tthe ------------------------EQTT---ALEE--NK-------EQLL---------Q 8961_Tthe ------------------------ETPDLGCNL-----NNCQTNIEQQEY---------E WNK_Spur QQQQQHQAQHQQQQQQPQSTPHSQS---QLQPQPQQ-SV-------QQPV---------Q AqueK219_Aque ------------------------S---ENSEDSEK-ES-------VEDE---------Q WNK_e_Smoe ------------------------------------------------------------ WNK_a_Smoe ------------------------------------------------------------ WNK_d_Smoe ------------------------------------------------------------ WNK_c_Smoe ------------------------------------------------------------ WNK_b-2_Smoe ------------------------------------------------------------ WNK_b-1_Smoe ------------------------------------------------------------ GK075_Glam ------------------------------------------------------------ Wnk4_Hsap ------------------------------------------------------------ Wnk3_Hsap ------------------------------------------------------------ C46C2.1_Cele --IHVPKPS-------------EIPVQ--------------------------------- CG7177_Dmel Q-VMAPHQHQQPIQIPVQMQVPPTSVAPPIQ-----HTYNQQGGQVTL------------ Wnk1_Mmus ----------------------QIPISTP-------HVSTAQTGFSSVPITMAAGINQPL Wnk2_Mmus A-VKLPHPPGTPLAVPCQTIVPNAPAAIP-------LLAVAPQGVAALSIHPAVA-QIPA Wnk3_Mmus ------------------------------------------------------------ Wnk4_Mmus ------------------------------------------------------------ Wnk1_Hsap ----------------------QIPISTP-------HVSTAQTGFSSLPITMAAGITQPL Wnk2_Hsap A-VKLPHPPGAPLAMPCRTIVPNAPATIP-------LLAVAPPGVAALSIHSAVA-QLPG 17822_Tthe A-NQNEHL---------------------------------------------------- 8961_Tthe T-SKYDPI---------------------------------------------------- WNK_Spur TQAQVQVPTQLPQSLPSQQQQQQQQAQTQQFVQQTANYTQFPQGQA-YQQSVSQG-QLPQ AqueK219_Aque F-VSKKHSELTSAPVSSK-SLPSSSKTSP-------NLSKGKGGEEEREEHQSLS-AKGQ WNK_e_Smoe ------------------------------------------------------------ WNK_a_Smoe ------------------------------------------------------------ WNK_d_Smoe ------------------------------------------------------------ WNK_c_Smoe ------------------------------------------------------------ WNK_b-2_Smoe ------------------------------------------------------------ WNK_b-1_Smoe ------------------------------------------------------------ GK075_Glam ------------------------------------------------------------ Wnk4_Hsap -----------------------------------ALQPPGGVPSS-------------- Wnk3_Hsap ------------------------------------------------------------ C46C2.1_Cele -NVA-----TTAAP--VAAN--NVP-PSPA------------------------------ CG7177_Dmel ---------SDAQQ-QQHPGFSAVP-QQA----APFIQQPTQQPIQ-------LS---MP Wnk1_Mmus LTLA-----SSATA-SSIPG--GSP-VVPNQ-LPTLLQPVNQLQSQ-------------- Wnk2_Mmus QPVY-----PAAFP-QMVPG--DIP-PSPHHTVQSLRATPPQLASP-------------- Wnk3_Mmus ------------------------------------------------------------ Wnk4_Mmus -----------------------------------ALQPPGGLPSS-------------- Wnk1_Hsap LTLA-----SSATT-AAIPG--VST-VVPSQ-LPTLLQPVTQLPSQ-------------- Wnk2_Hsap QPVY-----PAAFP-QMAPT--DVP-PSPHHTVQNMRATPPQPALP-----PQPTLPPQP 17822_Tthe ------------------------------------------------------------ 8961_Tthe ------------------------------------------------------------ WNK_Spur QPIQQPLQQPIQQP-LQQPS--QVP-STPQRTASDQHAKVTRTVSGGSQHAPQPQVQPQA AqueK219_Aque GDIV-----NRTYSEDVHQS--DLSSGSATNS---------------------------- WNK_e_Smoe ------------------------------------------------------------ WNK_a_Smoe ------------------------------------------------------------ WNK_d_Smoe ------------------------------------------------------------ WNK_c_Smoe ------------------------------------------------------------ WNK_b-2_Smoe ------------------------------------------------------------ WNK_b-1_Smoe ------------------------------------------------------------ GK075_Glam ------------------------------------------------------------ Wnk4_Hsap ------------------------------------------------------------ Wnk3_Hsap ------------------------------------------------------------ C46C2.1_Cele --------------------------------------------PFKTEDI--------- CG7177_Dmel LE-------Q------------------------------QLQQLLHSQPAQQQQA---- Wnk1_Mmus ---------------------------------------------VHPQLLQPTTVQSIG Wnk2_Mmus ---------------------------------------------VPPQPVQPSV-IH-- Wnk3_Mmus ------------------------------------------------------------ Wnk4_Mmus ------------------------------------------------------------ Wnk1_Hsap ---------------------------------------------VHPQLLQPA-VQSMG Wnk2_Hsap VLPPQPTLPPQPVLPPQPTRPPQPVLPPQPMLPPQPVLPPQPALPVRPEPLQP----H-- 17822_Tthe ---------------------------------------------------NQESQQQVN 8961_Tthe ---------------------------------------------------NQQNANQLE WNK_Spur ------------------------------------------------------------ AqueK219_Aque ------------------------------------------------------------ WNK_e_Smoe ------------------------------------------------------------ WNK_a_Smoe ------------------------------------------------------------ WNK_d_Smoe ------------------------------------------------------------ WNK_c_Smoe ------------------------------------------------------------ WNK_b-2_Smoe ------------------------------------------------------------ WNK_b-1_Smoe ------------------------------------------------------------ GK075_Glam -----------------------------------------------HVPAN-------- Wnk4_Hsap ---------------------------------------L-AESHLC--LPSAFALSIPR Wnk3_Hsap --LVQGQS----------------------------TVLP-------------------- C46C2.1_Cele ------------------------------------------------------------ CG7177_Dmel ----MSQQ----------------------------QQQP-LVQQQQLPLVQQQPPLVQQ Wnk1_Mmus IPANLGQA----------------------------AEGP-LPSGDV--LYQGFPSRLPP Wnk2_Mmus LP----EQ----------------------------AAPT-AASGTQ--VLLGH----PP Wnk3_Mmus --VVQGQS----------------------------SVMP-------------------- Wnk4_Mmus ---------------------------------------P-AESHLC--LPSGFALSIPR Wnk1_Hsap IPANLGQA----------------------------AEVP-LSSGDV--LYQGFPPRLPP Wnk2_Hsap LP----EQ----------------------------AAPA-ATPGSQ--ILLGH----PA 17822_Tthe QEQNIQKDDKQN-SHEEHNDDEN--DNLKQKYYMNKN----------------------- 8961_Tthe SEQIMQNDS-QNMKSNSDGSSQTSSMSINQGIYLN------------------------- WNK_Spur ------TQ----------------------------SQPIQQ-------QMQ----LLPP AqueK219_Aque ------------------------------------------------------------ WNK_e_Smoe ------------------------------------------------------------ WNK_a_Smoe ------------------------------------------------------------ WNK_d_Smoe ------------------------------------------------------------ WNK_c_Smoe ------------------------------------------------------------ WNK_b-2_Smoe ------------------------------------------------------------ WNK_b-1_Smoe ------------------------------------------------------------ GK075_Glam ------------------------------------------------------------ Wnk4_Hsap S----------------------------------------------------------- Wnk3_Hsap VHVLGP------------------------------------------------------ C46C2.1_Cele ------------------------------------------------------QTPTLA CG7177_Dmel QQPLVQHQQPSV------------------------------------------------ Wnk1_Mmus QYPGDSNIAPSSNVASVCIHS-TVLAPPSMP--------------TEAL-ATQGYFPTVV Wnk2_Mmus SYTAD----VAAPVSAVSLPP-AVLSPP-LP--------------DTLLPTVPDLLPKVP Wnk3_Mmus IYAAGV------------------------------------------------------ Wnk4_Mmus S----------------------------------------------------------- Wnk1_Hsap QYPGDSNIAPSSNVASVCIHS-TVLSPP-MP--------------TEVL-ATPGYFPTVV Wnk2_Hsap PYAVD----VAAQVPTVPVPPAAVLSPP-LP--------------EVLLPAAPELLPQFP 17822_Tthe -------IIFTNNNGMIT----QILPAPEKRLDEEFKMRKITEDSKEI-QEEDRLYDNNI 8961_Tthe ----------------------------------------------------------TI WNK_Spur SQS-----AQQQQHASVTNTT-SVLKQS-IP--------------ATQQSGQPSHVPQVC AqueK219_Aque -------------TQSINVNS-VSDATPT----------------GKDL-ARSASFYSGS WNK_e_Smoe ------------------------------------------------------------ WNK_a_Smoe ------------------------------------------------------------ WNK_d_Smoe ------------------------------------------------------------ WNK_c_Smoe ------------------------------------------------------------ WNK_b-2_Smoe ------------------------------------------------------------ WNK_b-1_Smoe ------------------------------------------------------------ GK075_Glam ------------------------------------------------------------ Wnk4_Hsap ------------------------------------------------------------ Wnk3_Hsap -------------------T--VVSQPQV------------------------------- C46C2.1_Cele QNTVPRT----------------------------------------------------- CG7177_Dmel ---------------QHQQP--LVQQPQ-------------------------------- Wnk1_Mmus QPYVESTPLVPMGSVG-GQV--QVSQPAV------------------------------- Wnk2_Mmus SS---------------------------------------------------------- Wnk3_Mmus -------------------G--VVSQSQI------------------------------- Wnk4_Mmus ------------------------------------------------------------ Wnk1_Hsap QPYVESNLLVPMGGVG-GQV--QVSQPGG------------------------------- Wnk2_Hsap SS---------------------------------------------------------- 17822_Tthe QSRVQNNDSISFYNQG-GKNSENISFSQIN-----------ASNAKEVVE--DFSFDKQT 8961_Tthe N-------------------------YSLAFNEYSQDTQYRYAFT-LEIRDSLYPFDITV WNK_Spur QNSVQQTQQQQIQQVGQGQP--QQQQQQQ------------------------------- AqueK219_Aque QTQSETQTLIA--------------HSQT------------------------------- WNK_e_Smoe ------------------------------------------------------------ WNK_a_Smoe ------------------------------------------------------------ WNK_d_Smoe ------------------------------------------------------------ WNK_c_Smoe ------------------------------------------------------------ WNK_b-2_Smoe ------------------------------------------------------------ WNK_b-1_Smoe ------------------------------------------------------------ GK075_Glam ------------------------------------------------------------ Wnk4_Hsap ------------------------------------------------------------ Wnk3_Hsap ----------------------------------------SPLTV--------------- C46C2.1_Cele ------------------------------ISTDASGL--VINTP--------------- CG7177_Dmel ---------------------------QQQPQPQNQQPQPQTQQT-HVV--QQQPPQQQP Wnk1_Mmus ------------------------SLTQQPPTTSSQQA--VLEST--------------- Wnk2_Mmus -------------------------LAP-TVVAASQSA--PAQTSSLLL--PTNP----- Wnk3_Mmus ----------------------------------------SPLTI--------------- Wnk4_Mmus ------------------------------------------------------------ Wnk1_Hsap ------------------------SLAQ-APTTSSQQA--VLEST--------------- Wnk2_Hsap -------------------------LAT-V-SASVQSV--PTQTATLLP--PANP----- 17822_Tthe K--------------TQIIDKKLEQQEEQKQTQNSQVL--IIDSAQNRRDIQSADFSQSP 8961_Tthe DKNLINNGSYNKESITNLIKEALNQIECQDL-EKLHNF--IIDDAVAKCKLLFKD----- WNK_Spur ------------------------QQ--QQQQQQQQQQ--QLQQL--QQ--QQQQPQHHP AqueK219_Aque ------------------------S---LSGTAVSQSI--AAQSSSGSA--QSQT----- WNK_e_Smoe ------------------------------------------------------------ WNK_a_Smoe ------------------------------------------------------------ WNK_d_Smoe ------------------------------------------------------------ WNK_c_Smoe ------------------------------------------------------------ WNK_b-2_Smoe ------------------------------------------------------------ WNK_b-1_Smoe ------------------------------------------------------------ GK075_Glam ------------------------------------------------------------ Wnk4_Hsap ------------------------------------------------------------ Wnk3_Hsap -----------------------QKVPQIKPV---------------------------- C46C2.1_Cele -----------------------ASIASPSPA---------------------------- CG7177_Dmel AVE------------------QISQISSQVPVQ--------------------------- Wnk1_Mmus -----------------------QGVSQAAP----------------------------- Wnk2_Mmus PLP------------------TGPAVAGPCPA---------------------------- Wnk3_Mmus -----------------------QKVSQIKPV---------------------------- Wnk4_Mmus ------------------------------------------------------------ Wnk1_Hsap -----------------------QGVSQVAP----------------------------- Wnk2_Hsap PLP------------------GGPGIASPCPT---------------------------- 17822_Tthe ----------------------------NYHTKKSEGNNTPITPIVNNILYAFKNPQSDE 8961_Tthe ---------------------------------------------INNAYFMFMNLVSEF WNK_Spur IQPGTTLGQPHMMSAPSYVSIAASSAAAVAT----------------------------- AqueK219_Aque --T------------------SSSSISSGYHSQ--------------------------- WNK_e_Smoe ------------------------------------------------------------ WNK_a_Smoe ------------------------------------------------------------ WNK_d_Smoe ------------------------------------------------------------ WNK_c_Smoe ------------------------------------------------------------ WNK_b-2_Smoe ------------------------------------------------------------ WNK_b-1_Smoe ------------------------------------------------------------ GK075_Glam ------------------------------------------------------------ Wnk4_Hsap ------------------------------------------------------------ Wnk3_Hsap ------------------------------------------------------------ C46C2.1_Cele ------------------------------------------------------------ CG7177_Dmel ------------------------------------------------------------ Wnk1_Mmus ------------------------------------------------------------ Wnk2_Mmus ------------------------------------------------------------ Wnk3_Mmus ------------------------------------------------------------ Wnk4_Mmus ------------------------------------------------------------ Wnk1_Hsap ------------------------------------------------------------ Wnk2_Hsap ------------------------------------------------------------ 17822_Tthe K---------HKLIRQKSKSGEDFYVQKLQNIQNEDIQVSYSENLSMNGLQNNQQEYSK- 8961_Tthe QAKKKKFNKKE------------------------EM--AKKNSLSPSKSSNFQLNLTPD WNK_Spur ------------------------------------------------------------ AqueK219_Aque ------------------------------------------------------------ WNK_e_Smoe ------------------------------------------------------------ WNK_a_Smoe ------------------------------------------------------------ WNK_d_Smoe ------------------------------------------------------------ WNK_c_Smoe ------------------------------------------------------------ WNK_b-2_Smoe ------------------------------------------------------------ WNK_b-1_Smoe ------------------------------------------------------------ GK075_Glam ------------------------------------------------------------ Wnk4_Hsap ------------------------------------------------------------ Wnk3_Hsap --------------------S--------------------------------------Q C46C2.1_Cele ------------------------------------------------------------ CG7177_Dmel -----------------QENL--------------------------------------Q Wnk1_Mmus --------------------P--------------------------------------E Wnk2_Mmus ----------------VQLMV--------------------------------------E Wnk3_Mmus --------------------S--------------------------------------Q Wnk4_Mmus ------------------------------------------------------------ Wnk1_Hsap --------------------A--------------------------------------E Wnk2_Hsap ----------------VQLTV--------------------------------------E 17822_Tthe -----------------------------PSKGQSPKKIQDQLTNDQQYERILRRENDMN 8961_Tthe EKKQSLQQIQANISTNQQILVAKAIQDDDDDDNNSDHEIEDAVFYNA---YCDDYNR--- WNK_Spur --------------------A--------------------------------------V AqueK219_Aque ----------------S---S--------------------------------------S WNK_e_Smoe ------------------------------------------------------------ WNK_a_Smoe ------------------------------------------------------------ WNK_d_Smoe ------------------------------------------------------------ WNK_c_Smoe ------------------------------------------------------------ WNK_b-2_Smoe ------------------------------------------------------------ WNK_b-1_Smoe ------------------------------------------------------------ GK075_Glam ------------------------------------------------------------ Wnk4_Hsap ----------------------GPGSDF-------------------------------- Wnk3_Hsap PVGAEQ-----------Q-AALLKPD---------------------------------- C46C2.1_Cele ------------------------------------------------------------ CG7177_Dmel PIQV--------------NKDANVATDA-------------------------------- Wnk1_Mmus QTPITQ-----------S-QPTQPVPLV-------------------------------- Wnk2_Mmus VAQEEQ-----------VSQDKPPGPPQ-------------------------------- Wnk3_Mmus PIGAEQ-----------Q-ATLQNPD---------------------------------- Wnk4_Mmus ----------------------GPGSDF-------------------------------- Wnk1_Hsap PVAVAQ-----------T-QATQPTTLA-------------------------------- Wnk2_Hsap PVQEEQ-----------ASQDKPPGLPQ-------------------------------- 17822_Tthe -------------------------NSQKNENLNSQNNLQNI---GGVEHSE-FI----- 8961_Tthe -----------------------------------QDEYNHISSHNPQEYTQNQIYYQNN WNK_Spur PVSLATTTSNASAPAWHLAQDNRPQTVD-------------------------------- AqueK219_Aque ALALS------------SSSSTPPS----------------------------------- WNK_e_Smoe ------------------------------------------------------------ WNK_a_Smoe ------------------------------------------------------------ WNK_d_Smoe ------------------------------------------------------------ WNK_c_Smoe ------------------------------------------------------------ WNK_b-2_Smoe ------------------------------------------------------------ WNK_b-1_Smoe ------------------------------------------------------------ GK075_Glam -----------------------LDTAS-------------------------------- Wnk4_Hsap -SPGDSYASDAA----SG-------------LSDVGEGM----------GQMRRP-PGRN Wnk3_Hsap --LVRSLNQDVA----TTK-----------ENVS-SPDN-PSGNGKQ----DRIK-QRRA C46C2.1_Cele ----P-SATDVA----STTAPVTPAPTP-TTTTDGGAAA-AS--------TTT---EN-- CG7177_Dmel -MSLNSAHGA--LEPAPKT-------EPQ-NSADAEKQQKQTGTG------TR----SQK Wnk1_Mmus -TSADSAHSDVA----SG-------------MSDGNENA-PSSSGRHEGRTTKRH-YRKS Wnk2_Mmus -SSESFGGSDVT----SGR-----------DLSDSCEG--TFGGGRLEGRTARKH-HRRS Wnk3_Mmus --FVRSLNQDVT----SVK-----------ENTN-NPDT-PSGNGKQ----DRNK-QRRA Wnk4_Mmus -SPGDSYASDAA----SG-------------LSDMGEG-----------GQMRKN-PVKT Wnk1_Hsap -SSVDSAHSDVA----SG-------------MSDGNENV-PSSSGRHEGRTTKRH-YRKS Wnk2_Hsap -SCESYGGSDVT----SGK-----------ELSDSCEG--AFGGGRLEGRAARKH-HRRS 17822_Tthe -------------------------------------------SNQESGASLDKY-SNKS 8961_Tthe YSRLDNTQNNIK----N-----------------DHLTH-QTSEPSHQNHSRQQS-YI-- WNK_Spur -AS--KVGSDGQAWSSPGLE-------RKDVLTDAASAY-PSGTGEESGAEGSQNVEKRQ AqueK219_Aque -VEADTTQSNGS----SG----------------------PGGSGG----SFR------- WNK_e_Smoe ------------------------------------------------------------ WNK_a_Smoe ------------------------------------------------------------ WNK_d_Smoe ------------------------------------------------------------ WNK_c_Smoe ------------------------------------------------------------ WNK_b-2_Smoe ------------------------------------------------------------ WNK_b-1_Smoe ------------------------------------------------------------ GK075_Glam -----SVV--------------------------------------------I---KRRP Wnk4_Hsap -------------------------------------------------------L---- Wnk3_Hsap -------------------------------------------------------S--CP C46C2.1_Cele --------------------------------------------------------KEEK CG7177_Dmel -------------------------------------------------------PRRSN Wnk1_Mmus -------------------------------------------------------VRSRS Wnk2_Mmus -------------------------------------------------------TRARS Wnk3_Mmus -------------------------------------------------------S--CP Wnk4_Mmus -------------------------------------------------------L---- Wnk1_Hsap -------------------------------------------------------VRSRS Wnk2_Hsap -------------------------------------------------------TRARS 17822_Tthe LENTNNDSNKRASPSNGVVYYDDLANQFTMQNDHSDIYSNHEYQQDYSKQPSMVEIQQYQ 8961_Tthe ---------------------------------------------------SSHSVQLNS WNK_Spur ---------------------------------------------------------GKK AqueK219_Aque -------------------------------------------------------SKKGS WNK_e_Smoe ------------------------------------------------------------ WNK_a_Smoe ------------------------------------------------------------ WNK_d_Smoe ------------------------------------------------------------ WNK_c_Smoe ------------------------------------------------------------ WNK_b-2_Smoe ------------------------------------------------------------ WNK_b-1_Smoe ------------------------------------------------------------ GK075_Glam -------------------------------------------------------TKSSL Wnk4_Hsap --RR--RPRSR--LRVTSVSD-QNDRVVECQL-QTHNSK-MVTFRFDLD-GDSPEEIAA- Wnk3_Hsap RPEK--GTKFQ--LTVLQVST-SGDNMVECQL-ETHNNK-MVTFKFDVD-GDAPEDIAD- C46C2.1_Cele RKSN--KRKVV--MEILGCDESRNFALVSCRL-DTS-HK-SVTFQFAPG-TDKPCTIAT- CG7177_Dmel RSG--NERIPK--LSVTSV---DEGSVINCHM-EN-KLK-TITFKFDIGDRDETASDIT- Wnk1_Mmus RHEK--TSRPK--LRILNVSN-KGDRVVECQL-ETHNRK-MVTFKFDLD-GDNPEEIAT- Wnk2_Mmus RQER--ASRPR--LTILNVCN-TGDKMVECQL-ETHNHK-MVTFKFDLD-GDAPDEIAT- Wnk3_Mmus RPEK--GTKFQ--LTVLQVSV-SGDNMVECQL-ETHNNK-MVTFKFDVD-GDAPEDIAD- Wnk4_Mmus --RR--RPRSR--LRVTSVSD-QSDRVVECQL-QTHNSK-MVTFRFDLD-GDSPEEIAA- Wnk1_Hsap RHEK--TSRPK--LRILNVSN-KGDRVVECQL-ETHNRK-MVTFKFDLD-GDNPEEIAT- Wnk2_Hsap RQER--ASRPR--LTILNVCN-TGDKMVECQL-ETHNHK-MVTFKFDLD-GDAPDEIAT- 17822_Tthe DQES--NDVPPYSLTVLEEK-ELKNQKFLIKFKFQHFNR-MQTFEIDNT-HEDFSEQSIF 8961_Tthe IQEQ--TQNF--KFM------NANPQYFNNQQQ-NKNSQNIQLFSIDSH-NQKNSPAIPQ WNK_Spur KHSKTSKKRPK--LSIIS--V-DEDQVIECSL-ETHRGD-TIVFKFSED--DQLDGIVS- AqueK219_Aque RTKD--SKRIK--LKFN--EK-VKDNVISCSL-QTSAGQ-VINFKFSLD-YDKPNEIFN- WNK_e_Smoe ------------------------------------------------------------ WNK_a_Smoe ------------------------------------------------------------ WNK_d_Smoe ------------------------------------------------------------ WNK_c_Smoe ------------------------------------------------------------ WNK_b-2_Smoe ------------------------------------------------------------ WNK_b-1_Smoe ------------------------------------------------------------ GK075_Glam TSR--IN--------------------VE----IS-LPN-QVSFVYVLSLMDKPVEIVD- Wnk4_Hsap ----AMVYNEFIL----------------------------------------------- Wnk3_Hsap ----YMVEDNFVL----------------------------------------------- C46C2.1_Cele ----KLLAEDCLL----------------------------------------------- CG7177_Dmel ----KMFEP--------------------------------------------------- Wnk1_Mmus ----IMVNNDFIL----------------------------------------------- Wnk2_Mmus ----YMVEHDFIL----------------------------------------------- Wnk3_Mmus ----YMVEDNFVL----------------------------------------------- Wnk4_Mmus ----AMVYNEFIL----------------------------------------------- Wnk1_Hsap ----IMVNNDFIL----------------------------------------------- Wnk2_Hsap ----YMVEHDFIL----------------------------------------------- 17822_Tthe AFAQIKAAELEIVDLEEQFAYDLYNLVYERYNQFHSQVSQGQRKIVQED--------SSS 8961_Tthe SVQK-------------------------------------NQIFPTPPQFSEKNQCQSP WNK_Spur ----NLTVAKWVH----------------------------------------------- AqueK219_Aque ----NLVKTGHLS----------------------------------------------- WNK_e_Smoe ------------------------------------------------------------ WNK_a_Smoe ------------------------------------------------------------ WNK_d_Smoe ------------------------------------------------------------ WNK_c_Smoe ------------------------------------------------------------ WNK_b-2_Smoe ------------------------------------------------------------ WNK_b-1_Smoe ------------------------------------------------------------ GK075_Glam ----ELEMVH-------------------------------------------------- Wnk4_Hsap ------PSERDGFLRRIREIIQRVETLLKRDTGP-MEAAEDTLSPQ-------------- Wnk3_Hsap ------ESEKEKFVEELRAIVGQAQEILHVHFAT-ERA--TGVDSITVDSNSS------- C46C2.1_Cele ------KVHVHIVEAQLGEVIQLINSDGKKGVGT-KLATV--LDP--------------- CG7177_Dmel -------------------TIHGVETLPSGGGGA-EQ-----------SNCNLT--LE-- Wnk1_Mmus ------AIERESFVAQVREIIEKADEMLSEDVSV-EPEGDQGLESLQGKDDYG------- Wnk2_Mmus ------PAERETFIEQMKDVMDKAEDMLSEDTDA-DHGSDTGTSPPHLGTCGL------- Wnk3_Mmus ------ENEKEKFVEELRAIVGQAQEILHVHSAV-EKS--IGVDSVALESNSN------- Wnk4_Mmus ------PSERDGFLSRIREIIQRVETLLKRDAGP-PEAAEDALSPQ-------------- Wnk1_Hsap ------AIERESFVDQVREIIEKADEMLSEDVSV-EPEGDQGLESLQGKDDYG------- Wnk2_Hsap ------QAERETFIEQMKDVMDKAEDMLSEDTDA-DRGSDPGTSPPHLSTCGL------- 17822_Tthe PN-YTQPYCIEIFIRHYQNYMKEIEEYLKVESSH-NLKVRQSKEQIQLHRFHLN--QQE- 8961_Tthe PNHYNFCKLIDNFIDYYKKYWEQNYEQISYETQE-LLKFRQQKELIELQRLHIA--QRDA WNK_Spur ------EQHAGLFKEQLLKVMEDAKRLG-PGLHL-QP----GPSSSTVGDDTG------- AqueK219_Aque ------QLEGTDFISQFQKVVDTVRSKSTVDSTSSDTKKNPG-GPLRSTSVSYSSIVK-- WNK_e_Smoe ------------------------------------------------------------ WNK_a_Smoe ------------------------------------------------------------ WNK_d_Smoe ------------------------------------------------------------ WNK_c_Smoe ------------------------------------------------------------ WNK_b-2_Smoe ------------------------------------------------------------ WNK_b-1_Smoe ------------------------------------------------------------ GK075_Glam -------------------D---------------------------------------- Wnk4_Hsap ------------------------------------EEPA-PLPA-------------LP Wnk3_Hsap -------------------------QTGSSE-------------QVQINSTSTQTSNE-- C46C2.1_Cele ----------------------------------NSTEPP-TITAV------------MP CG7177_Dmel ---ARS------------------------------------------------------ Wnk1_Mmus -------------------------FPGSQKLEGEFKQPI-AVSS-------------MP Wnk2_Mmus -------------------------ATGEENR---------------------------Q Wnk3_Mmus -------------------------QTGSSE-------------QVLINSASTQTSNE-- Wnk4_Mmus ------------------------------------EEPA-ALPA-------------LP Wnk1_Hsap -------------------------FSGSQKLEGEFKQPI-PASS-------------MP Wnk2_Hsap -------------------------GTGEESR---------------------------Q 17822_Tthe -------------------NQIDYESQAQSQIVQKSPQTIQKVVA-------------VN 8961_Tthe WLTN--QMNLTANQYE---KQDAFQLQGKQGIQSQSNFII-YQSD-------------QA WNK_Spur -------------------------TITSQQLQEGVVPPS-PGTAVNSSDASPPSGDESQ AqueK219_Aque ---QDSDQSKHSESYQKGGARSDSPYDGSGQLGGVKRDGL-A------------------ WNK_e_Smoe ------------------------------------------------------------ WNK_a_Smoe ------------------------------------------------------------ WNK_d_Smoe ------------------------------------------------------------ WNK_c_Smoe ------------------------------------------------------------ WNK_b-2_Smoe ------------------------------------------------------------ WNK_b-1_Smoe ------------------------------------------------------------ GK075_Glam ------------------------------------------------------------ Wnk4_Hsap V-----------PLP-----------------------------DPSNEELQSST----- Wnk3_Hsap --------------SAPQS-----SPVGRWRFC--------INQTIR------------- C46C2.1_Cele K-----------DSS--------------------------------------------- CG7177_Dmel ----------------------------------------HLSNIPNAKEPQLNVS---- Wnk1_Mmus Q-----------QIGVPTSSLTQVVHSAGRRFI--------VSPVPESRLRESKV----- Wnk2_Mmus S-----------QANAPVYQ-QNVLHTGKRWFI--------ICPVAEHPAT--------- Wnk3_Mmus --------------SAPQS-----SPVGRWRFC--------INQTIK------------- Wnk4_Mmus --------------------------------------------GPPNAEPQRSI----- Wnk1_Hsap Q-----------QIGIPTSSLTQVVHSAGRRFI--------VSPVPESRLRESKV----- Wnk2_Hsap S-----------QANAPVYQ-QNVLHTGKRWFI--------ICPVAEHPAP--------- 17822_Tthe Q-----------QQLLPQQNINYANNSNNQDFF--------ESPE--------------- 8961_Tthe NNIQTNHSVLDISNISNVKDIDNDNHISPQLK---------------------------- WNK_Spur Q-----------QLNAPQQSFE--MAVGKHLTAESQQGEQQLRPVENQHLPLSRKGSSPL AqueK219_Aque --------------------LSEASPHSRRKFQ--------VSDVFV------------- WNK_e_Smoe ------------------------------------------------------------ WNK_a_Smoe ------------------------------------------------------------ WNK_d_Smoe ------------------------------------------------------------ WNK_c_Smoe ------------------------------------------------------------ WNK_b-2_Smoe ------------------------------------------------------------ WNK_b-1_Smoe ------------------------------------------------------------ GK075_Glam ------------------------------------------------------------ Wnk4_Hsap -------SLEHRSWTAFSTSSSSPGTPLSPGN---------------------------- Wnk3_Hsap -----------------NRETQSPPSL-Q---HS------MSAVPG-------------- C46C2.1_Cele ---------------AATASNTKPKIEIEKTPPT----RDASQEPN-NVQVT---NVRKV CG7177_Dmel ----------------------TPPTTTSTMSSSSTASRDAPNSSN-DVTIGSGSVSRKT Wnk1_Mmus -------FTSDISDPVVASTSQAPGMNLSHSASS-------------------------- Wnk2_Mmus -----------------DTSESSPPLPLSSLQPE------ASQDP--------------- Wnk3_Mmus -----------------NREAQSPPSL-Q---PS------MAMVPG-------------- Wnk4_Mmus -------SPEQRSWAAFSTSPSSPGTPLSPGA---------------------------- Wnk1_Hsap -------FPSEITDTVAASTAQSPGMNLSHSASS-------------------------- Wnk2_Hsap -----------------EAPESSPPLPLSSLPPE------ASQGPCRGLTLPCL-PWRRA 17822_Tthe ------------------------------------------------------------ 8961_Tthe ------------------------------------------------------------ WNK_Spur IVNQPQQMGSEDSDQTRPKPNQSPPAAIENMPSQ-------------------------- AqueK219_Aque -----------------ERPNEKPSITSQGSAES-------------------------- WNK_e_Smoe ------------------------------------------------------------ WNK_a_Smoe ------------------------------------------------------------ WNK_d_Smoe ------------------------------------------------------------ WNK_c_Smoe ------------------------------------------------------------ WNK_b-2_Smoe ------------------------------------------------------------ WNK_b-1_Smoe ------------------------------------------------------------ GK075_Glam ------------------------------------------------------------ Wnk4_Hsap -----------------------PFSPGTP---------------IS--PGPIFP---IT Wnk3_Hsap -----------RH----------------P----L--PSP--KNTS-------------- C46C2.1_Cele SQE-----S---------N-AESVQSIPRPGGIIV--MSP--TNQTDSAPPPTGA---AA CG7177_Dmel STASEYTSLSI--------D----YMPDSNI--TPTGPEPPLDDG--KDKKPCSLAIARM Wnk1_Mmus --------LSLQQAF---SELKHGQMTEGP----N--TAP--PNFNH-MAGPTF------ Wnk2_Mmus ----------------------------------A--PYP--DQLSL-TDKPSFP---AA Wnk3_Mmus -----------LH----------------P----F--PSS--RNTS-------------- Wnk4_Mmus -----------------------PFSPGTP----P----------VF--PCPIFP---IT Wnk1_Hsap --------LSLQQAF---SELRRAQMTEGP----N--TAP--PNFSH--TGPTFP---VV Wnk2_Hsap ACG-----AVFLSLF---S-AESAQSKQPP----D--SAPYKDQLSS-KEQPSFL---AS 17822_Tthe ------------------------------------------------------------ 8961_Tthe ------------------------------------------------------------ WNK_Spur --------VPVQQSHHLQMELRT--------------------------PQPVYP---S- AqueK219_Aque --------MTVMSPV---H-------SEDT----C------------I------------ WNK_e_Smoe ------------------------------------------------------------ WNK_a_Smoe ------------------------------------------------------------ WNK_d_Smoe ------------------------------------------------------------ WNK_c_Smoe ------------------------------------------------------------ WNK_b-2_Smoe ------------------------------------------------------------ WNK_b-1_Smoe ------------------------------------------------------------ GK075_Glam ------------------------------------------------------------ Wnk4_Hsap ------------------------------------------------------------ Wnk3_Hsap -----------------------------------NKEISRDTLLTIENNPCHRALFTSK C46C2.1_Cele KPSRFQVTKSADPIA-----------TPI-SSSIS------------------------- CG7177_Dmel QKLLESAG-NGAPRSLN---------LPL-N----------------------------- Wnk1_Mmus SPFLASIAGVQTVAAST-------PSVSVPITSSPLNDISTSVMQSETALPTEKGIVGVT Wnk2_Mmus QQLLSQAGSSNPPGGAS---------APL-APSSPP------------------------ Wnk3_Mmus -----------------------------------NQAISQNTVFTIENNPGHRELFTSK Wnk4_Mmus ------------------------------------------------------------ Wnk1_Hsap PPFLSSIAGVPTTAAAT---------APVPATSSPPNDISTSVIQSEVTVPTEEGIAGVA Wnk2_Hsap QQLLSQAGPSNPPGAPP---------APL-APSSPP------------------------ 17822_Tthe ------------------------------------------------------------ 8961_Tthe ------------------------------------------------------------ WNK_Spur -----QAGVPDQGMMQGMPMMGAYSMMPM-LSSQG------------------------- AqueK219_Aque --------------------------LPPPSSSSSSSDNKST------------------ WNK_e_Smoe ------------------------------------------------------------ WNK_a_Smoe ------------------------------------------------------------ WNK_d_Smoe ------------------------------------------------------------ WNK_c_Smoe ------------------------------------------------------------ WNK_b-2_Smoe ------------------------------------------------------------ WNK_b-1_Smoe ------------------------------------------------------------ GK075_Glam ------------------------------------------------------------ Wnk4_Hsap ------------------------------------------------------------ Wnk3_Hsap -SEHKDVVDGKISECASVETKQPAILYQVEDNRQIMAPVTNSSSYSTTSVR---AVPAEC C46C2.1_Cele ---------------------------------------------TATVIP---IVAATP CG7177_Dmel ------------------------------------------------------------ Wnk1_Mmus TTSTGVVASGGLTTMS-----------------------------VSE-SPTSSSAVSSS Wnk2_Mmus ---------------------------------------------VTTVIP---AAPATS Wnk3_Mmus -LDHKDVVDGKIGEHASIETEQSSISYQVEDDRQIMTPATDNSNYSAALVC---PVPGEC Wnk4_Mmus ------------------------------------------------------------ Wnk1_Hsap T-STGVVTSGGLPIPP-----------------------------VSE-SPVLSSVVSSI Wnk2_Hsap ---------------------------------------------VTA-LPQDGAAPATS 17822_Tthe ------------------------------------------------------------ 8961_Tthe ------------------------------------------------------------ WNK_Spur ---------------------------------------------NVVF----------- AqueK219_Aque ------------------------------------------------QDPT-SVFHSTS WNK_e_Smoe ------------------------------------------------------------ WNK_a_Smoe ------------------------------------------------------------ WNK_d_Smoe ------------------------------------------------------------ WNK_c_Smoe ------------------------------------------------------------ WNK_b-2_Smoe ------------------------------------------------------------ WNK_b-1_Smoe ------------------------------------------------------------ GK075_Glam ------------------------------------------------------------ Wnk4_Hsap ---------------------------------------------------SPPCHPSPS Wnk3_Hsap EGL-------TKQASIFIPVYPC----------------HQTASQADALMSHPGE----- C46C2.1_Cele TNI-------TSEPVIVQPIT----------------------AQVITHLA----TP--S CG7177_Dmel -----RHLKI-QEDLKHTRSL-DDLTAVKITFDMPNKAALDTSENAQQATEAEAEKPK-- Wnk1_Mmus TVPAVVTVST---PSQPVQAS-TSGSIASSTGSFPPGTFSTTTATTMGSVVAPDAKPPT- Wnk2_Mmus TVPE----------------S-A----------------AGTAMQAGGPGTHQG------ Wnk3_Mmus EAL-------TSQAGMFMPTYPN----------------QQAAVLADVHIAYPGE----- Wnk4_Mmus ---------------------------------------------------SPSCYPCP- Wnk1_Hsap TIPAVVSISTTS-PSLQVPTS-TSEIVVSSTALYPSVTVSATSASAGGSTATPGPKPPA- Wnk2_Hsap TMPE----------------P-A----------------SGTASQAGGPGTPQG------ 17822_Tthe ------------------------------------------------------------ 8961_Tthe ------------------------------------------------------------ WNK_Spur -VPMATQA--GAPQMYMHPQQ-A----------------QQMYMQQQ------------M AqueK219_Aque VLPT----------------C-T----------------LGTGD-KGNLGDT----P--S WNK_e_Smoe ------------------------------------------------------------ WNK_a_Smoe ------------------------------------------------------------ WNK_d_Smoe ------------------------------------------------------------ WNK_c_Smoe ------------------------------------------------------------ WNK_b-2_Smoe ------------------------------------------------------------ WNK_b-1_Smoe ------------------------------------------------------------ GK075_Glam ------------------------------------------------------------ Wnk4_Hsap PFSPISSQVSS------------------------------------------------- Wnk3_Hsap STQ--------------------------------------------------------- C46C2.1_Cele PVS---HSLSS------------------------------------------------- CG7177_Dmel ---DKSGQAVG------------------------------------------------- Wnk1_Mmus ---VLLQQVAS------------------------------------------------- Wnk2_Mmus ------------------------------------------------------------ Wnk3_Mmus SVP--------------------------------------------------------- Wnk4_Mmus -----FSQVSS------------------------------------------------- Wnk1_Hsap ---VVSQQAAG------------------------------------------------- Wnk2_Hsap ------------------------------------------------------------ 17822_Tthe ------------------------------------------------------------ 8961_Tthe ------------------------------------------------------------ WNK_Spur PMQ----QHLSQQPPMQQHQQPPMQQLQQQPPIMQHQQQPPMQQQQQPQQQLPMHQQQPP AqueK219_Aque SVA--------------------------------------------------------- WNK_e_Smoe ------------------------------------------------------------ WNK_a_Smoe ------------------------------------------------------------ WNK_d_Smoe ------------------------------------------------------------ WNK_c_Smoe ------------------------------------------------------------ WNK_b-2_Smoe ------------------------------------------------------------ WNK_b-1_Smoe ------------------------------------------------------------ GK075_Glam ------------------------------------------------------------ Wnk4_Hsap --------------------NPSPHPTSS----PLPFSSSTPEFPVPLSQ---------- Wnk3_Hsap -------TSGNS-L-T-------------------TL-------------------AFDQ C46C2.1_Cele --------------------NS------------SPSATTHSN-MSSIQS-------TTS CG7177_Dmel -----NQG-TGA-----------ANTLEQLKIELENITHAHA-FASAVVA-------SIN Wnk1_Mmus -----NTA-GVAIVTSVSTTTPFPGMASQ---PSLPLSSSTSA-PTLAET-------MVV Wnk2_Mmus -----PAS-VHE--------------------TLQPLAETRSA-QCTAQP-------LST Wnk3_Mmus -------IGGNAALTS------------------VLV-------------------SSDQ Wnk4_Mmus --------------------NPYPQAPSS----LLPLSSSASQVPLP------------- Wnk1_Hsap -----STT-VGATLTSVSTTTSFPSTASQ---LCIQLSSSTST-PTLAET-------VVV Wnk2_Hsap -----LTS-ELE--------------------TSQPLAETHEA-PLAVQP-------LVV 17822_Tthe ------------------------------------------------------------ 8961_Tthe ------------------------------------------------------------ WNK_Spur MQQQPLPS-VQD--------------------QVQPLLQQQPTQP--------------- AqueK219_Aque -------T-GNS----------------------SAISSASSS-YSNLQPSGTGTITTVE WNK_e_Smoe ------------------------------------------------------------ WNK_a_Smoe ------------------------------------------------------------ WNK_d_Smoe ------------------------------------------------------------ WNK_c_Smoe ------------------------------------------------------------ WNK_b-2_Smoe ------------------------------------------------------------ WNK_b-1_Smoe ------------------------------------------------------------ GK075_Glam ------------------------------------------------------------ Wnk4_Hsap ------------------------------------------------------------ Wnk3_Hsap KPQTLSVQQPAMDAEFISQEGETT-----VNTEAS------------------------- C46C2.1_Cele VPGRRFTVQPVSQAES-------G--------------ISSSISTPHPEPTPA------- CG7177_Dmel --NRAP-HQASPAM---------------------------------------------- Wnk1_Mmus --SAHS-LD--------------------KASHSSTAGLGLSFCAPSSSSSSG-TAV-ST Wnk2_Mmus --GQGP-CTPALEASRCST----GLGEPISTREVSTQGEPLPASVP--EPSPP-TGATQS Wnk3_Mmus KPQSLSVQQPTIDAEFISKEGETT-----VNTETS------------------------- Wnk4_Mmus ------------------------------------------------------------ Wnk1_Hsap --SAHS-LD--------------------KTSHSSTTGLAFSLSAPSSSSSPG-AGV-SS Wnk2_Hsap --GLAP-CTPAPEAA--------------STRDASAPREPLPPPAP--EPSPH-SGTPQP 17822_Tthe ------------------------------------------------------------ 8961_Tthe ------------------------------------------------------------ WNK_Spur ----------------------------IQQGGQQAQIPPQQLQQV--QPTQPGQQVATS AqueK219_Aque APNKKFEIEDVIDPETLS-------------TE-SSCENLIPDDKA--E----------- WNK_e_Smoe ------------------------------------------------------------ WNK_a_Smoe ------------------------------------------------------------ WNK_d_Smoe ------------------------------------------------------------ WNK_c_Smoe ------------------------------------------------------------ WNK_b-2_Smoe ------------------------------------------------------------ WNK_b-1_Smoe ------------------------------------------------------------ GK075_Glam ------------------------------------------------------------ Wnk4_Hsap ---CP---WS--SLPTTSPPTFSPTCSQV-TLSSPF--FPPCPSTSSFPSTTAAPLLSLA Wnk3_Hsap -------------------------SPK--TVIPT--------QTPG------------- C46C2.1_Cele -----------------------------------I--TSCPPPVPSVPPVV-S------ CG7177_Dmel -----------------SSLKATSGQPQTQEITKPN--NGAGPSVPSVGQNTPTAALTSA Wnk1_Mmus SVSQP---GMVHPLVISSAVVSTPGLPQ--PVVPTS--TPLLPQVPNIPPLV-QPV---- Wnk2_Mmus VPGQP---PPPLPITVGAISLAAPQ----------------------------------- Wnk3_Mmus -------------------------SPK--AVIAT--------QTPG------------- Wnk4_Mmus --------SS--SLPISAPLPFSPSYPQD-PLSPTS--LPVCPSPPSLPSTTAAPLLSLA Wnk1_Hsap YISQP---GGLHPLVIPSVIASTPILPQ--AAGPTS--TPLLPQVPSIPPLV-QPV---- Wnk2_Hsap ALGQP---APLLPAAVGAVSLATSQ----------------------------------- 17822_Tthe ------------------------------------------------------------ 8961_Tthe ------------------------------------------------------------ WNK_Spur VQGQAHAQPHQQPQTTAALSTAAPT---Q-S----------------VAG-GAQPQQSQA AqueK219_Aque --------------------------PKN-EVTPTESSTIIKDDEST------------- WNK_e_Smoe ------------------------------------------------------------ WNK_a_Smoe ------------------------------------------------------------ WNK_d_Smoe ------------------------------------------------------------ WNK_c_Smoe ------------------------------------------------------------ WNK_b-2_Smoe ------------------------------------------------------------ WNK_b-1_Smoe ------------------------------------------------------------ GK075_Glam ------------------------------------------------------------ Wnk4_Hsap SAFSLA------VMTVAQSLL-------------S------------------------- Wnk3_Hsap ------------------------------------------------------------ C46C2.1_Cele ------------NGTLNLEVA----------PKQTPSATNQNVDTQHSSSTASTA--TLV CG7177_Dmel RGSGSS------VYNSRRTSI--DNSVGSDMHLHTATNLEGTVSNP------DPIPTEAS Wnk1_Mmus ----VN------VPAVQQTLI----------HS-Q------------------------- Wnk2_Mmus ----------------------------------L------------------------- Wnk3_Mmus ------------------------------------------------------------ Wnk4_Mmus SAFSLA------VMTVAQSLL-------------S------------------------- Wnk1_Hsap ----AN------VPAVQQTLI----------HS-Q------------------------- Wnk2_Hsap ----------------------------------L------------------------- 17822_Tthe ----------IN------------------------------------------------ 8961_Tthe -----------D------------------------------------------------ WNK_Spur KAAQVAGVARLKELDHKLSQLHKKPNP----HQ-Q------------------------- AqueK219_Aque ---------------------------------------SVELSTPPTFSDEDTLTYARV WNK_e_Smoe ------------------------------------------------------------ WNK_a_Smoe ------------------------------------------------------------ WNK_d_Smoe ------------------------------------------------------------ WNK_c_Smoe ------------------------------------------------------------ WNK_b-2_Smoe ------------------------------------------------------------ WNK_b-1_Smoe ------------------------------------------------------------ GK075_Glam ------------------------------------------------------------ Wnk4_Hsap ----------PSPGLLSQSPPAPPSPL-----------P--------------------- Wnk3_Hsap --------------LEPTT-LQPTTVL-----------ESDGERP--------------P C46C2.1_Cele S---------ETPATVHVTPISVPAP---------------VQE--------------PL CG7177_Dmel VGITIATGHEKQLSKQPSLEKPSATSI-----------LTNNSDPPQRNPSNGSINQ--- Wnk1_Mmus ----------PQPALLPNQPHTHCPEM-----------D--ADTQ--------------S Wnk2_Mmus ----------PSPPLGPTAPPPPPSAL-----------ESDGEGP-------------PP Wnk3_Mmus --------------FEPAV-ILPATIL-----------ESDGERP--------------P Wnk4_Mmus ----------PSPGLLSQSPPAPPGPL-----------P--------------------- Wnk1_Hsap ----------PQPALLPNQPHTHCPEV-----------D--SDTQ--------------P Wnk2_Hsap ----------PSPPLGPTVPPQPPSAL-----------ESDGEGP-------------PP 17822_Tthe ------------------------------------------------------------ 8961_Tthe ------------------------------------------------------------ WNK_Spur ----------QTPAKVPSQPPTMLQQQ-----------ISQ--GQ--------------S AqueK219_Aque KEV--ESSSKPHPPTSTNPPMYPPYSVQPVDPPQPLLLSPFSRIP----PTHGTLLENPL WNK_e_Smoe ------------------------------------------------------------ WNK_a_Smoe ------------------------------------------------------------ WNK_d_Smoe ------------------------------------------------------------ WNK_c_Smoe ------------------------------------------------------------ WNK_b-2_Smoe ------------------------------------------------------------ WNK_b-1_Smoe ------------------------------------------------------------ GK075_Glam ------------------------------------------------------------ Wnk4_Hsap ------------------------------------------------------------ Wnk3_Hsap KLEFADNRIKTLDEKLRNLLYQEHSISS-IYPESQKDTQSIDSPFSSSAEDTLSCPV--- C46C2.1_Cele VIDHHSDVLTQLDSELRKVSGVSHSAS--------------------------------- CG7177_Dmel ------NSIADLEKKLAALRNTENTEEARTQ----HVSR--------------------- Wnk1_Mmus KAPGID-DIKTLEEKLRSL-FSEHSSSG-TQ----HASVSLETPLVVE--TTVTP----- Wnk2_Mmus RVGFVDNTIKSLDEKLRTLLYQEHVPTS-SA----SAGTPMEASD-RD--FTLEP----- Wnk3_Mmus KMEFADNRIKTLDEKLRNLLYQEHSISS-ICPESQKDTQSIDSPFSSSAEDILSYSM--- Wnk4_Mmus ------------------------------------------------------------ Wnk1_Hsap KAPGID-DIKTLEEKLRSL-FSEHSSSG-AQ----HASVSLETSLVIE--STVTP----- Wnk2_Hsap RVGFVDSTIKSLDEKLRTLLYQEHVPTS-SA----SAGTPVEVGD-RD--FTLEP----- 17822_Tthe ----------NIQKKANNLNQ--QAIEQ-FQQPLYQNNQNINSGIGNIPNNALITNNNNN 8961_Tthe ----------SIDMELSNMLLD-NPSSN-ILGNNYSKTHSQQ-IHQSSLHNSLSLNT--- WNK_Spur NVPYH-----------------NQVSVS-VA----QLTTPNNSQSSAN--IVLTP----- AqueK219_Aque V---FD-GFMKFMHYMKLL-FEEPSIAA--L----LQQISINN----------------- WNK_e_Smoe ------------------------------------------------------------ WNK_a_Smoe ------------------------------------------------------------ WNK_d_Smoe ------------------------------------------------------------ WNK_c_Smoe ------------------------------------------------------------ WNK_b-2_Smoe ------------------------------------------------------------ WNK_b-1_Smoe ------------------------------------------------------------ GK075_Glam ------------------------------------------------------------ Wnk4_Hsap ------------------------------------------------------------ Wnk3_Hsap ----T--EVIAISHCGIK--------------------------DSPVQSPNFQQTGS-K C46C2.1_Cele --------------------------------------------------------PS-T CG7177_Dmel ------------------------------------------------------------ Wnk1_Mmus ---------------GIT--------------------------TT-------AVAPS-K Wnk2_Mmus --------------------------------------------LR-------GDLPS-A Wnk3_Mmus ----P--EVIAISHCGIQ--------------------------DSPAQSPNFQQTGS-K Wnk4_Mmus ------------------------------------------------------------ Wnk1_Hsap ---------------GIP--------------------------TT-------AVAPS-K Wnk2_Hsap --------------------------------------------LR-------GDQPR-S 17822_Tthe MNQNYNQNSTSYSNIGIT--------------------------NNNSNIPNNAIPGS-L 8961_Tthe ----ANQNNLGL-MQQIQ--------------------------VEAIISPSNQSIGNQQ WNK_Spur ---------------QPVSNMLAPVFHPIQDERKASLMDAQSLPIH-------NYLPR-P AqueK219_Aque ------------------------------------------------------------ WNK_e_Smoe ------------------------------------------------------------ WNK_a_Smoe ------------------------------------------------------------ WNK_d_Smoe ------------------------------------------------------------ WNK_c_Smoe ------------------------------------------------------------ WNK_b-2_Smoe ------------------------------------------------------------ WNK_b-1_Smoe ------------------------------------------------------------ GK075_Glam ------------------------------------------------------------ Wnk4_Hsap ------------------------------------------------------------ Wnk3_Hsap LLSNVAA------SQPANISVFKRDLNVITSVPS-------ELC---------------- C46C2.1_Cele VVESLTS---------------------M--TPQ-------TIP---------------- CG7177_Dmel -------VQEQK------------------------------------------------ Wnk1_Mmus LMTSTTS------T-------------CL--PPT-------SLP---------------- Wnk2_Mmus ------------------------------------------------------------ Wnk3_Mmus ILSNVAA------SQPAHISVFKKDLNVITSVPS-------ELC---------------- Wnk4_Mmus ------------------------------------------------------------ Wnk1_Hsap LLTSTTS------T-------------CL--PPT-------NLP---------------- Wnk2_Hsap -----------------------------------------EVC---------------- 17822_Tthe LNFNSNQ------NTQGNI------------------------ASHHLSPNSSANTFEEN 8961_Tthe FIQNMQT------SEP----------------------------------TTSASISNKK WNK_Spur ASEPVPDFQTTPYV-------------DP--QQDSVQVVPEKSE---------------- AqueK219_Aque -------------P-------------DQ--PPSSGSTANGHTP---------------- WNK_e_Smoe ------------------------------------------------------------ WNK_a_Smoe -------------FASGNI-------------------------KRHLSPQ--------- WNK_d_Smoe -------------TES-----------------------------PTVEAG--------- WNK_c_Smoe ------------------------------------------------------------ WNK_b-2_Smoe ----------------------------------------------TVSSR--------- WNK_b-1_Smoe ----------------------------------------------TVSSR--------- GK075_Glam ------------------------------------------------------------ Wnk4_Hsap ----------------------SLPLPPPVAPGGQESPSPH------------------- Wnk3_Hsap --------------LHEMSSDASLPGDPEAYPAAVSSGGAIHLQT--------------- C46C2.1_Cele --------------L----ACQTVPASIGQAPAVIAA--AHAA----------------- CG7177_Dmel ------------------------------------------------------------ Wnk1_Mmus --------------L----GAAGMPVMPVGTPGQVSTPGTHASAP--------------- Wnk2_Mmus ---------------------------LS------------------------------- Wnk3_Mmus --------------LHEMSPDASLPGDPEAYPAAVSSDGTIHLQT--------------- Wnk4_Mmus ----------------------SLPLS--LASCDQESLSAQ------------------- Wnk1_Hsap --------------L----GTVALPVTPVVTPGQVSTPVSTTT----------------- Wnk2_Hsap --------------G----GDLALPPVPK------------------------------- 17822_Tthe QEAQLQINFPPQ----------------------IQRSGSIQINAQSTQQNNMKNQIYIP 8961_Tthe TNLPIRTPTPKQTLNES-----------------ISQKQSQ------------------- WNK_Spur --------------------ENQI----------------QIEQP--------------- AqueK219_Aque --------------S----NGQ----SPTATNGYAPAPGSNGH----------------- WNK_e_Smoe ----MHSTDST------------------------------------------------- WNK_a_Smoe -LPCVDVASPP------------------------------------------------- WNK_d_Smoe -QASVKSRSPR------------------------------------------------- WNK_c_Smoe ------------------------------------------------------------ WNK_b-2_Smoe -NSEVESLSPQ------------------------------------------------- WNK_b-1_Smoe -NSEVESLSPQ------------------------------------------------- GK075_Glam ------------------------------------------------------------ Wnk4_Hsap ------------------------------------------------------------ Wnk3_Hsap ----------------------------------------------------------GG C46C2.1_Cele ------------------------------------------------------------ CG7177_Dmel ------------------------------------------------------------ Wnk1_Mmus ----------------------------------------------------------VG Wnk2_Mmus ------------------------------------------------------------ Wnk3_Mmus ----------------------------------------------------------GG Wnk4_Mmus ------------------------------------------------------------ Wnk1_Hsap ------------------------------------------------------------ Wnk2_Hsap ------------------------------------------------------------ 17822_Tthe QNNQYQIQLPQIVNKNQYAQTTTHQQQQQQIKQKYLKEEMLNAQSFNPREGRQDNKGISH 8961_Tthe -----------------------------------------SIQSKNSQQNQNPQLAVNS WNK_Spur ----------------------------------------------------------A- AqueK219_Aque ------------------------------------------------------------ WNK_e_Smoe ------------------------------------------------------------ WNK_a_Smoe ------------------------------------------------------------ WNK_d_Smoe ------------------------------------------------------------ WNK_c_Smoe ------------------------------------------------------------ WNK_b-2_Smoe ------------------------------------------------------------ WNK_b-1_Smoe ------------------------------------------------------------ GK075_Glam ------------------------------------------------------------ Wnk4_Hsap ------------------------------------------------------------ Wnk3_Hsap GY--FGL--S-------------------------------------------------- C46C2.1_Cele --S---LIPN-------------------------------------------------- CG7177_Dmel ------------------------------------------------------------ Wnk1_Mmus TAT--GVKP--------------------------------------------------- Wnk2_Mmus ------------------------------------------------------------ Wnk3_Mmus GY--FGL--S-------------------------------------------------- Wnk4_Mmus ------------------------------------------------------------ Wnk1_Hsap --S--GVKP--------------------------------------------------- Wnk2_Hsap ------------------------------------------------------------ 17822_Tthe SQ--SFS--NISTQAIQKVKQSQSKHRLHHAENSNAQGMYSSNQQSQPINKSQTQQLSYF 8961_Tthe YS--QNL--NNTQNSIQNQNNLNSNNEKIKTNTIN--SSNSSIIQTQPIRTHH------- WNK_Spur --RPVSPKP--------------------------------------------------- AqueK219_Aque --S--AVNPA-------------------------------------------------- WNK_e_Smoe ------------------------------------------------------------ WNK_a_Smoe ------------------------------------------------------------ WNK_d_Smoe -----T------------------------------------------------------ WNK_c_Smoe ------------------------------------------------------------ WNK_b-2_Smoe ------------------------------------------------------------ WNK_b-1_Smoe ------------------------------------------------------------ GK075_Glam ------------------------------------------------------------ Wnk4_Hsap ------------------------------------------------------------ Wnk3_Hsap ------------------------------------------------------------ C46C2.1_Cele ------------------------------------------------------------ CG7177_Dmel ------------------------------------------------------------ Wnk1_Mmus ------------------------------------------------------------ Wnk2_Mmus ------------------------------------------------------------ Wnk3_Mmus ------------------------------------------------------------ Wnk4_Mmus ------------------------------------------------------------ Wnk1_Hsap ------------------------------------------------------------ Wnk2_Hsap ------------------------------------------------------------ 17822_Tthe NQQNLSQQIQFQNPMQHQQQQQNSNFFQQGQQQQISQVNNSNYIFPQNNASQNMQQ-TPQ 8961_Tthe ----GSIQISMQNPKTNNKMQQSDKLYYQNPLQQQ---------------QQ---L-QQQ WNK_Spur ------------------------------------------------------------ AqueK219_Aque ------------------------------------------------------------ WNK_e_Smoe ------------------------------------------------------------ WNK_a_Smoe ------------------------------------------------------------ WNK_d_Smoe -----------------------------------------------------GPLSYSP WNK_c_Smoe ------------------------------------------------------------ WNK_b-2_Smoe ------------------------------------------------------------ WNK_b-1_Smoe ------------------------------------------------------------ GK075_Glam ------------------------------------------------------------ Wnk4_Hsap ------------------------------------------------------------ Wnk3_Hsap ------------------------------------FTCPSLKNPISKK----SW----- C46C2.1_Cele ------------------------------------ASVPQSPSR--LDAETG------- CG7177_Dmel ------------------------------------------------------------ Wnk1_Mmus ------------------------------------GTTPPK--P--TKTVVPPV----- Wnk2_Mmus ------------------------------------------------------------ Wnk3_Mmus ------------------------------------FTCPSLKNPISRK----SW----- Wnk4_Mmus ------------------------------------------------------------ Wnk1_Hsap ------------------------------------GTAPSKPPL--TKAPVLPV----- Wnk2_Hsap ------------------------------------------------------------ 17822_Tthe SFPGRQ---LNQRQQKYS-YASEDTQQN---QQS--------------NLIKQGSHFKNQ 8961_Tthe QQHFNP-QQQQQQFQQQT----FPQSSQQQIQQNKMNSKPPTP----KQIIS-------- WNK_Spur ------------------------------------ASSPTKKSR----FSVSSV----- AqueK219_Aque ------------------------------------------------------------ WNK_e_Smoe HGEG---M-MFGRFEEVSV-GCLSTDTDSEP----------------------------- WNK_a_Smoe RGEG---T-MYGRFEEVYSGGSDPSEANAF--------------------------F--- WNK_d_Smoe RLEGTSSS-MHGRFEEVTY-HPEGSDQYDAPH-----------------------IF--- WNK_c_Smoe ------------------------------------------------------------ WNK_b-2_Smoe NLEG---T-MHGRFEEFTY-QSLPMRSHATP----------------------------- WNK_b-1_Smoe NLEG---T-MHGRFEEFTY-QSLPMRSHATP----------------------------- GK075_Glam ------------------------------------------------------------ Wnk4_Hsap ------------------------------------------------------------ Wnk3_Hsap -------------------TRKLKSWAY--------RLRQS------------------- C46C2.1_Cele ------------------------------------------------------------ CG7177_Dmel ------------------------------------------------------------ Wnk1_Mmus -------------------GTELSAGTV--------PCEQL------------------- Wnk2_Mmus ---------------------D-------------------------------------- Wnk3_Mmus -------------------TRKLKSWAY--------RLRQS------------------- Wnk4_Mmus ------------------------------------------------------------ Wnk1_Hsap -------------------GTELPAGTL--------PSEQL------------------- Wnk2_Hsap ---------------------E-------------------------------------- 17822_Tthe SNHQVKLSSSQEQYTSK----------TPNIQDDSNNPYQL------------------- 8961_Tthe ----------------QNNNFHFSNNLT--------PSSQV------------------- WNK_Spur -------------------EDKKDAAAV--------TEE-KPKEEISEGNAGSKTETVGD AqueK219_Aque --------------------------------------HMR------------------- WNK_e_Smoe ------------------------------------------------------------ WNK_a_Smoe ------------------------------------------------------------ WNK_d_Smoe ------------------------------------------------------------ WNK_c_Smoe ------------------------------------------------------------ WNK_b-2_Smoe ------------------------------------------------------------ WNK_b-1_Smoe ------------------------------------------------------------ GK075_Glam ------------------------------------------------------------ Wnk4_Hsap ------------------------------------------------------------ Wnk3_Hsap --TSFF------------------------------------------------------ C46C2.1_Cele ------------------------------------------------------------ CG7177_Dmel ------------------------------------------------------------ Wnk1_Mmus --PPFP------------------------------------------------------ Wnk2_Mmus -----K------------------------------------------------------ Wnk3_Mmus --TSFF------------------------------------------------------ Wnk4_Mmus ------------------------------------------------------------ Wnk1_Hsap --PPFP------------------------------------------------------ Wnk2_Hsap -----A------------------------------------------------------ 17822_Tthe --PQQQQRQQQQNQQPQYQQHASH---STQLENDNSIRKNSQNNGQSNYNAINPPFFIQP 8961_Tthe --AQQPLKPIKHNQQQV-KQNFIH---SATNSQDSSY------------FS--FQ-FMNE WNK_Spur KSSREP------------------------------------------------------ AqueK219_Aque --PPV------------------------------------------------------- WNK_e_Smoe ----------EPT--TG-LDNNGH---FSPAEE--------------------------- WNK_a_Smoe ---------SNESSDDG-EETSFP---ATPKSD--------------------------- WNK_d_Smoe ------SSGSSEIREDG-DDWDLTGEVSSPVAT--------------------------- WNK_c_Smoe ------------------------------------------------------------ WNK_b-2_Smoe ----------RENQETA-KLWDFH---STPVPD--------------------------- WNK_b-1_Smoe ----------RENQETA-KLWDFH---STPVPD--------------------------- GK075_Glam ------------------------------------------------------------ Wnk4_Hsap ------------------------------------------------------------ Wnk3_Hsap -----K--------RSKVRQ--VETE-E-MRSAIAPDPIPLT--------RESTADTRAL C46C2.1_Cele --------LAG--LHEKLEA--LKMEQD-RREDMGDDAIGTT--------TTDGKDEIPI CG7177_Dmel ------------------------------------------------------------ Wnk1_Mmus -----GPSLIQ--SQQPLED--LD--AQ-LRRTLSPETITVAPAVGPLSTMSSTTVTEAG Wnk2_Mmus -----TPSLTQ--QTQPSLE-----------------KSETAPAGWA------------- Wnk3_Mmus -----K--------RSKVRQ--VETE-D-KRSAIASDPIPLT--------REFSSDTRAL Wnk4_Mmus ------------------------------------------------------------ Wnk1_Hsap -----GPSLTQ--SQQPLED--LD--AQ-LRRTLSPEMITVTSAVGPVSMAAPTAITEAG Wnk2_Hsap -----VSGRVQ--LPQPLVE-----------------KSELAPTRGA------------- 17822_Tthe LDNKNGNQFTQGISQQNLKQQQTQ--NQ-FIKSLSPP----------------------G 8961_Tthe IGGQPGTNQQSQISHSKIKSSQNL--NQYFYKSQTPP----------------------N WNK_Spur -----AIGMDK--DQEPARK--EE--KK-GRFTVAPAPCTVGDAV--------------- AqueK219_Aque ------------------------------------------------------------ WNK_e_Smoe ------------------------------------------------------------ WNK_a_Smoe ------------------------------------------------------------ WNK_d_Smoe ------------------------------------------------------------ WNK_c_Smoe ------------------------------------------------------------ WNK_b-2_Smoe ------------------------------------------------------------ WNK_b-1_Smoe ------------------------------------------------------------ GK075_Glam ------------------------------------------------------------ Wnk4_Hsap ---------------TA------------------------------------------- Wnk3_Hsap NRC---------------KAMSGS-----FQRGRF----------Q--VITIPQQQSAKM C46C2.1_Cele DTL---------------KGLAEALGKVIHADGRE----------T--TPMPPDHP---- CG7177_Dmel -----------------TSTGVEE-----PAQGQL----------KIDLQVAGPGGQVQT Wnk1_Mmus TRLQK---DGTEGHVTATSSGAGV-----VKMGRF----------Q--VSVTMDDAQKER Wnk2_Mmus ---LAQREQGASSPMTAESSSSNT-----LGCDSDAGQVASDSSTA--PSVPQDASGSS- Wnk3_Mmus SRC---------------KAMSGS-----FQRGRF----------Q--VITVPQQQPVKM Wnk4_Mmus ---------------TA------------------------------------------- Wnk1_Hsap TQPQKGVSQVKEGPVLATSSGAGV-----FKMGRF----------Q--VSVAADGAQKEG Wnk2_Hsap -----VMEQGTSSSMTAESSPRSM-----LGYDRDGRQVASDSHVV--PSVPQDVPAFV- 17822_Tthe IQSRKETDQGKQKNLMIS-RPPSS-----GQQTRV------------QLTLNEQDVQQQI 8961_Tthe ------------------------------------------------------------ WNK_Spur ------------------------------------------------------------ AqueK219_Aque ---------------TSVSSSS--L----------GQQVYSLASVS--GGVAQSSASYA- WNK_e_Smoe ------------------------------------------------------------ WNK_a_Smoe ------------------------------------------------------------ WNK_d_Smoe ------------------------------------------------------------ WNK_c_Smoe ------------------------------------------------------------ WNK_b-2_Smoe ------------------------------------------------------------ WNK_b-1_Smoe ------------------------------------------------------------ GK075_Glam ------------------------------------------------------------ Wnk4_Hsap -----------------------EVES---EASPPPARPL-------------------- Wnk3_Hsap TSFGIEHISV-------FS-ETNHSSEEAF--IKTAKSQLVEI-EPA-TQ---NP--KTS C46C2.1_Cele ------------------------------DLTDASTQ---------------------- CG7177_Dmel NNSVQNG------------------SV-----VNTPTEVISSP-IQNVPLAINGIQLMYQ Wnk1_Mmus KNRSEDTKSV------HFESSTSESSV---LSSSSPESTLVKP-EPN-GISISGI--SLD Wnk2_Mmus -------VPT------HMDPKDQ--------NSSVPREALAAP-MQS-GPGSF-T----- Wnk3_Mmus MSFGKDHRPP-------FNKTTVQSSEQALTFAEAAVSQLIEV-EPA-MP---TH--KAS Wnk4_Mmus -----------------------ETEN---EASRNPAQPL-------------------- Wnk1_Hsap KNKSEDAKSV------HFESSTSESSV---LSSSSPESTLVKP-EPN-GITIPGI--SSD Wnk2_Hsap -------RPA------RVEPTDR--------DGGEAGESSAEP-PPS-DMGTVGG----- 17822_Tthe QNQYTQQNTMISPTYSQYNQSNSKRTS---DNFYAPQETVQSS-QQQ------------- 8961_Tthe ------------------------------------------------------------ WNK_Spur ------------------------------------KSDLVKSGETA-TQD---V--KDV AqueK219_Aque -------SPN------ETLPQ--------------------------------------- WNK_e_Smoe ------------------------------------------------------------ WNK_a_Smoe ---------------------ASDGSV---SSSLNPSL---------------------- WNK_d_Smoe ---------------------CQ-------------GT---------------------- WNK_c_Smoe ------------------------------------------------------------ WNK_b-2_Smoe ------------------------------------------------------------ WNK_b-1_Smoe ------------------------------------------------------------ GK075_Glam ------------------------------------------------------------ Wnk4_Hsap -PGE----------ARLAP----ISEEGKPQLV-GRFQVTSSK-EPAEP----------- Wnk3_Hsap FSYE----------KLQALQETCKENKGVPKQ-GDNFLSFSAAC-ETDV----------- C46C2.1_Cele -------------------------QLISPSNP-DVLTTMSSAVEGSAS----------- CG7177_Dmel QPQQ----------IHQLPGGTSTTTSGAGTQC---IVVPQVV-NQN------------- Wnk1_Mmus VPDS----------THKAPTPEAKSDAGQPTKV-GRFQVTTTA-NKVGR----------- Wnk2_Mmus ---V----------G-SPAQLRGARDSGSPHKRPGQQDNSSPA-KTVGR----------- Wnk3_Mmus VSSR----------KLRTLYETFKEDKGDPEQ-GD-IVSYSTAC-ETSV----------- Wnk4_Mmus -LGD----------ARLAP----ISEEGKPQLV-GRFQVTSSK-EPAEP----------- Wnk1_Hsap VPES----------AHKTTASEAKSDTGQPTKV-GRFQVTTTA-NKVGR----------- Wnk2_Hsap ---Q----------A-SHPQTLGARALGSPRKRPEQQDVSSPA-KTVGR----------- 17822_Tthe -----------------------------------------------------QSLSNVI 8961_Tthe ------------------------------------------------------------ WNK_Spur VSDLVSQTEKNIDKEGADVAETAKPSAGSPVKL-SRFQVNKVS-DKTSVVEGKTSAEQSV AqueK219_Aque ------------------------------------------------------------ WNK_e_Smoe ------------------------------------------------------------ WNK_a_Smoe ------------------------------------------------------------ WNK_d_Smoe ------------------------------------------------------------ WNK_c_Smoe ------------------------------------------------------------ WNK_b-2_Smoe ------------------------------------------------------------ WNK_b-1_Smoe ------------------------------------------------------------ GK075_Glam ------------------------------------------------------------ Wnk4_Hsap ---LP--------------------LQP-----------------TSP-TLSG--S-PK- Wnk3_Hsap ---SS--------------------VT-PEKEFEETSATGSSMQSGSE-LLLK------- C46C2.1_Cele ---ST--------------------MIEDIDAS--TSAVDASMMNSMP-PGAQNSTDQI- CG7177_Dmel -----------------------------------------GTHVQQPSNLQP--Q-QQ- Wnk1_Mmus ---FS--------------------VSRTEDKV--TELKKEG-PVTSP-PFRD--S-EQ- Wnk2_Mmus ---FS--------------------VVSTQDEW--TLASPHSLRYSAP-PDVY--LDEI- Wnk3_Mmus ---SS--------------------VA-TEKNV--TSTTEVSVQSGSE-PLDK------- Wnk4_Mmus ----P--------------------LQP-----------------ASP-TLSR--S-LK- Wnk1_Hsap ---FS--------------------VSKTEDKI--TDTKKEG-PVASP-PFMD--L-EQ- Wnk2_Hsap ---FS--------------------VVSTQDEW--TLASPHSLRYSAP-PDVY--LDEA- 17822_Tthe PSVATNQTNQQQQNQKLSQTPQ-QNLQSKQEEL--SAEQLNQQFY--------------- 8961_Tthe ------------------------------------------------------------ WNK_Spur PETAS--------------------IETNKDDQ--TDIEKQP-EAEQP-PLP-------- AqueK219_Aque ------------------------------------------------------------ WNK_e_Smoe ------------------EYPELVS----------------------------------- WNK_a_Smoe ---SAVEEPPEQDPASFNKLVELRRSDS-------------SQDH-------------AY WNK_d_Smoe ---FCLDVKTEQTPTNLLKIVEHQN----------------------------------- WNK_c_Smoe ------------------------------------------------------------ WNK_b-2_Smoe ------------------KRPEHAG----------------------------------- WNK_b-1_Smoe ------------------KRPEHAS----------------------------------- GK075_Glam ------------------------------------------------------------ Wnk4_Hsap ------PSTPQ-L-----------------------------------------TSESSD Wnk3_Hsap ------------------------------------------------------------ C46C2.1_Cele ------PAAMT-LSMDQECAQSMTSSITRNTTGTKLATFENLETALSSTLGTH-IRQ-PN CG7177_Dmel ------SVHPN-M-------------------------------------TQQPQQTPLN Wnk1_Mmus ------TVIPA-V-------------------------------------IPK-KEKPEL Wnk2_Mmus ------PSSPE-VKLAVRRVQ----------------------TA--SSIEVG-VEE-PA Wnk3_Mmus ------------------------------------------------------------ Wnk4_Mmus ------LPSPP-L-----------------------------------------TSESSD Wnk1_Hsap ------AVLPA-V-------------------------------------IPK-KEKPEL Wnk2_Hsap ------PSSPD-VKLAVRRAQ----------------------TA--SSIEVG-VGE-PV 17822_Tthe -QSLLSPNSQQVIKFQLQEQSN---------------------NA--PTPMVN-KQQ-LQ 8961_Tthe ------------------------------------------------------------ WNK_Spur ---------------------SATASLAI----------------------KE-ADREPS AqueK219_Aque ------------------------------------------------------------ WNK_e_Smoe ------------------------------------------------------------ WNK_a_Smoe SW----------EGIAVEREQT-------------------------------------- WNK_d_Smoe ------------------------------------------------------------ WNK_c_Smoe ------------------------------------------------------------ WNK_b-2_Smoe ------------------------------------------------------------ WNK_b-1_Smoe ------------------------------------------------------------ GK075_Glam ------------------------------------------------------------ Wnk4_Hsap TEDSAGGGPE--------TREALAE------------S---DRAAEGLGAGVEEEGDDG- Wnk3_Hsap -----------------------EREI-LTAGKQP-SS-DSEFSASLAGSGKSVAKTGP- C46C2.1_Cele APS------------------------------------------------SRDETTAP- CG7177_Dmel GHPSMVNT------------------------------LQQQP----------------- Wnk1_Mmus AEPSHLNGPS---------------------------S---DLEAAFLSRGTEDGSGSP- Wnk2_Mmus SSDSGDERPR--------RRSQVQKQS-SLPGTGGVASDFVKKATAFLHRSSRAGSLGP- Wnk3_Mmus -----------------------EKNE-STPGKQT-C--TNEFSATLAGNRKSVTKTRP- Wnk4_Mmus TEDSAAGGPE--------TREALAE------------S---DRAAEGLGVAVDDEKDEG- Wnk1_Hsap SEPSHLNGPS---------------------------S---DPEAAFLSRDVDDGSGSP- Wnk2_Hsap SSDSGDEGPR--------ARPPVQKQA-SLPVSGSVAGDFVKKATAFLQRPSRAGSLGP- 17822_Tthe NQQLQQQQTQ--------QQSQQQQQQ-QQNYQSVI------------------------ 8961_Tthe ASSNATQTLN--------QNSQGYNQA-HIPITPQH------------------------ WNK_Spur PHPQQGNEPAVDISVGPAIKP--ERKS-SLIG------SERDTPDSIASDGSSLPSFPP- AqueK219_Aque ---SDDETDG--------ERQQLLREITRIEEEEKRLKKDKERYQAHLRRGSAITHEYTN WNK_e_Smoe ---------------------SS------------------------------------- WNK_a_Smoe ---------------------LVVE----------------------------------- WNK_d_Smoe ---------------------VDS--------D--------------------------- WNK_c_Smoe ------------------------------------------------------------ WNK_b-2_Smoe ---------------------AVPE-------E--------------------------- WNK_b-1_Smoe ---------------------AVPE----------------------------------- GK075_Glam ------------------------------------------------------------ Wnk4_Hsap KE----PQ-V--------GGSPQPLSH-------PSPVWM-N-------YSYSSLCLSSE Wnk3_Hsap ESNQCLPHHE--------EQA-YA----------QTQSSL-F-------YSPSS-PM-SS C46C2.1_Cele MT----PSFTNERIGGGGGGGA-TSF----------SIGT-P-------PSHSPFPVSEC CG7177_Dmel ------------------PQQSLPMQ---------------------------------- Wnk1_Mmus HS----PPHL--------CSKSLPVQN-------LSQSLS-N-------SFNSS-YM-SS Wnk2_Mmus ET----PSRA--------GVK-VPTI----------SITS-F-------HSQSS-YI-SS Wnk3_Mmus EGDQYLPLRE--------EQA-YA----------QTQNSL-F-------YSPSS-PM-SS Wnk4_Mmus KE----PL-L--------GGSSPILSH-------PSPVWM-N-------YSYSSLCLSSE Wnk1_Hsap HS----PHQL--------SSKSLPSQN-------LSQSLS-N-------SFNSS-YM-SS Wnk2_Hsap ET----PSRV--------GMK-VPTI----------SVTS-F-------HSQSS-YI-SS 17822_Tthe ------------------------AQN-------NQQSQV-NSIQPQVIYSNQQ-QQ-NS 8961_Tthe ------------------------SKD----------------------HAQQN-YI-KS WNK_Spur EG----PTLQ--------QSAGLPGQPFGPGQGVFAQPESQS-------TPPLS-DV-GS AqueK219_Aque VM----PKTS--------AVT-YPTHH-------VTSTSS-A-------MLSSA-SL-GP WNK_e_Smoe ------------------------------------------------------------ WNK_a_Smoe ---------------------------------------------SSSC----G--G-VT WNK_d_Smoe ---------------------------------------------GAGC---------NE WNK_c_Smoe ------------------------------------------------------------ WNK_b-2_Smoe ---------------------------------------------GSSC---------EE WNK_b-1_Smoe ---------------------------------------------GSSC---------EE GK075_Glam ------------------------------------------------------------ Wnk4_Hsap -------------------------------------------------ESESS-G---- Wnk3_Hsap -------------------------------------------------DDESE-I---- C46C2.1_Cele ---------------------------------------------DYDLKGQMD-L---- CG7177_Dmel ------------------------------------------------------------ Wnk1_Mmus -------------------------------------------------DNESD-I---- Wnk2_Mmus -------------------------------------------------DNDSE-F---- Wnk3_Mmus -------------------------------------------------DNESE-I---- Wnk4_Mmus -------------------------------------------------ESESS-G---- Wnk1_Hsap -------------------------------------------------DNESD-I---- Wnk2_Hsap -------------------------------------------------DNDSE-L---- 17822_Tthe -------------------------------------------------NNLN---AQ-- 8961_Tthe -------------------------------------------------ET------P-- WNK_Spur -------------------------------------------------ASPGP-I-ANA AqueK219_Aque -------------------------------------------------KDERE-Q---- WNK_e_Smoe ---------TSKQDMVAQW------------------INSTSGTF--H-EGLKHGEVV-- WNK_a_Smoe -------------------------------------------------DLYKA-GEE-- WNK_d_Smoe VLVTIKSSGCPEQQMVVETSEDAVSGPEGSSDIAVAAVAAATTTTVAAVTTSSA-E---- WNK_c_Smoe -------------------------IKEE------------------------------- WNK_b-2_Smoe -------------------------------------------------EGSSA-G---- WNK_b-1_Smoe -------------------------------------------------EGSSA-G---- GK075_Glam ------------------------------------------------------------ Wnk4_Hsap -------EDEEFWAELQSLRQKH----LSEVETLQTLQKK-------------------- Wnk3_Hsap -------EDEDLKVELQRLREKH----IQEVVNLQTQQNK-------------------- C46C2.1_Cele -------ESED--PEVIQMIVRH----RMEQHKLLEKQRV-------------------- CG7177_Dmel ---TIQSQQQQ-HNQMPIISQQQ----QQQIL-MQQQQQQGSQQGSQQFNLPGTQQTHPQ Wnk1_Mmus -------EDEDLRLELRRLREKH----LKEIQDLQSRQKH-------------------- Wnk2_Mmus -------EDADIKKELRSLREKH----LKEISELQSQQKQ-------------------- Wnk3_Mmus -------EDEDLKVELQRLREKH----IQEVVSLQTQQNK-------------------- Wnk4_Mmus -------EDEEFWAELQNLRQKH----LSEVEALQTLQKK-------------------- Wnk1_Hsap -------EDEDLKLELRRLRDKH----LKEIQDLQSRQKH-------------------- Wnk2_Hsap -------EDADIKKELQSLREKH----LKEISELQSQQKQ-------------------- 17822_Tthe -------QQQQQQLQQQQLQQQQ----QQQL--LQQQQQQ-------------------- 8961_Tthe -------EICQLQKPLTKLTKKQICMQRMSM--INSNSDL-------------------- WNK_Spur DLGQVQPSQAEAARELQELLKRQ----DEERAKILHRHRS-------------------- AqueK219_Aque -------QQQQQQQQQQQQQQQS----LQQQLHYQQQQQ--------------------- WNK_e_Smoe -------NPEQREQQHQVLASEE----QQQ-----EQQQE-------------------- WNK_a_Smoe -------DGEEMAHEMVLLMLKQ----EEEIKELQKRHEQ-------------------- WNK_d_Smoe -------QDESIARELKLLALRQ----EQELRELQRKHES-------------------- WNK_c_Smoe ------------------------------------------------------------ WNK_b-2_Smoe -------IDDPLEWEMAVLAHKQ----EQELRQLRRQHEQ-------------------- WNK_b-1_Smoe -------IDDPLEWEMAVLAHKQ----EQELRQLRRQHEQ-------------------- GK075_Glam -----------------NVGLYR-----EELL-VR------------------------- Wnk4_Hsap --EIEDLYSRLGKQPP-------------------------------------------- Wnk3_Hsap --ELQELYERLRSIKD-------------------------------------------- C46C2.1_Cele --EIERLRSKIRVP-RA------------------------------------------- CG7177_Dmel HQFIQSQPNQLHSLP-P------------------------------------------- Wnk1_Mmus --EIESLYTKLGKVPP-------------------------------------------- Wnk2_Mmus --EIEALYRRLGKPLPP------------------------------------------- Wnk3_Mmus --ELQELYERLRATKD-------------------------------------------- Wnk4_Mmus --EIEDLYSRLGKQPP-------------------------------------------- Wnk1_Hsap --EIESLYTKLGKVPP-------------------------------------------- Wnk2_Hsap --EIEALYRRLGKPLPP------------------------------------------- 17822_Tthe --QLQQ--SQQQQQ---------------------------------------------- 8961_Tthe --SCQE--IGQH------------------------------------------------ WNK_Spur --EMQEFIAHYPQTTPP------------------------------------------- AqueK219_Aque -----QLHQHLN------------------------------------------------ WNK_e_Smoe --QLLKAE---REDDGI------------------------------------------- WNK_a_Smoe --ALFM------------------------------------------------------ WNK_d_Smoe --ALLEIRNRCRCKRSSSLSSPQSSPHNQNMDSLSRLLDTDFDLQQLVASQAVDTAAQEA WNK_c_Smoe ------------------------------------------------------------ WNK_b-2_Smoe --AVLELRDRYKQKPG-------------------------------------------- WNK_b-1_Smoe --AVLELRDRYKQKPG-------------------------------------------- GK075_Glam ------------------------------------------------------------ Wnk4_Hsap ------------------------------------------------------------ Wnk3_Hsap ------------------------------------------------------------ C46C2.1_Cele ------------------------------------------------------------ CG7177_Dmel ------------------------------------------------------------ Wnk1_Mmus ------------------------------------------------------------ Wnk2_Mmus ------------------------------------------------------------ Wnk3_Mmus ------------------------------------------------------------ Wnk4_Mmus ------------------------------------------------------------ Wnk1_Hsap ------------------------------------------------------------ Wnk2_Hsap ------------------------------------------------------------ 17822_Tthe ------------------------------------------------------------ 8961_Tthe ------------------------------------------------------------ WNK_Spur ------------------------------------------------------------ AqueK219_Aque ------------------------------------------------------------ WNK_e_Smoe -------NTSVTDMHTSSVGDSVSEATVSEVSGAKLEDGF----------DNTSVVGGPR WNK_a_Smoe ------------------------------------------------------------ WNK_d_Smoe LPFDCDAGETSTAYRISTAGTSSSP-STSLSAVCKPDEGFCFFDQERAVEDHHRPPSSPS WNK_c_Smoe ------------------------------------------------------------ WNK_b-2_Smoe ------------------------------------------------------------ WNK_b-1_Smoe ------------------------------------------------------------ GK075_Glam ------------------------------------------------------------ Wnk4_Hsap ------------------------------------------------------------ Wnk3_Hsap ------------------------------------------------------------ C46C2.1_Cele ------------------------------------------------------------ CG7177_Dmel ------------------------------------------------------------ Wnk1_Mmus ------------------------------------------------------------ Wnk2_Mmus ------------------------------------------------------------ Wnk3_Mmus ------------------------------------------------------------ Wnk4_Mmus ------------------------------------------------------------ Wnk1_Hsap ------------------------------------------------------------ Wnk2_Hsap ------------------------------------------------------------ 17822_Tthe ------------------------------------------------------------ 8961_Tthe ------------------------------------------------------------ WNK_Spur ------------------------------------------------------------ AqueK219_Aque ------------------------------------------------------------ WNK_e_Smoe ---------------------------------------------------ERECVPGEL WNK_a_Smoe ------------------------------------------------------------ WNK_d_Smoe SASCSNDCFADLVDIAKATSLAPELERTLKPAGTWPECSFLSQQDATGRKENGLCEPGAL WNK_c_Smoe ----------------------------------------------------PSCRP--- WNK_b-2_Smoe ------------------------------------------------------------ WNK_b-1_Smoe ------------------------------------------------------------ GK075_Glam ------------------------------------------------------------ Wnk4_Hsap --------------------------PGIV---------A-------------------- Wnk3_Hsap --------------------------SKTQ---STE---I-------------------- C46C2.1_Cele ---------------------------TSV---------N-------------------- CG7177_Dmel --------------------------QVVS---------M-------------------- Wnk1_Mmus --------------------------AVII---------P-------------------- Wnk2_Mmus --------------------------NVGF---------F-------------------- Wnk3_Mmus --------------------------NKAQ---SSE---V-------------------- Wnk4_Mmus --------------------------PGIV---------A-------------------- Wnk1_Hsap --------------------------AVII---------P-------------------- Wnk2_Hsap --------------------------NVGF---------F-------------------- 17822_Tthe ------------------------------------------------------------ 8961_Tthe ------------------------------------------------------------ WNK_Spur --------------------------QS-------------------------------- AqueK219_Aque -----------------------------Y---------Y-------------------- WNK_e_Smoe ----------------------CE----ISVNRMDCAVVEAATPQ--------------- WNK_a_Smoe ------------------------------------------------------------ WNK_d_Smoe RYETLFDGSERFVDATCSERPSSEMVGEFSGR----EAVEPGKQQQGSLEQRQALRIGGG WNK_c_Smoe --------------------------GRIQI----------------------------- WNK_b-2_Smoe --------------------------MRFCGR----PSLE-------------------- WNK_b-1_Smoe --------------------------MRFCGR----PSLE-------------------- GK075_Glam ------------------------------------------------------------ Wnk4_Hsap --PAAMLSSRQR-----------------RLSKGSFP-TSRRNSLQR------------- Wnk3_Hsap --PLPPASPRRP-----------------RSFKSKLRS--RPQSLTHVDNGIVATGKSCL C46C2.1_Cele --PEMI--GDDE-----------------ADT----TLTALQSALGN------------- CG7177_Dmel --AQGNL----------------------------------------------------- Wnk1_Mmus --PAAPLSGRRR-----------------RPTKSKGSKSSRSSSLGN------------- Wnk2_Mmus --HTAPPMGRRR-----------------KTSKSKLKAGKLLNPLVQ------------- Wnk3_Mmus --PLSPASPRRP-----------------RSFKSKLRS--RPQSMTHSDNLVVK------ Wnk4_Mmus --PAAMLSCRQR-----------------RLSKGSFP-TSRRNSLQR------------- Wnk1_Hsap --PAAPLSGRRR-----------------RPTKSKGSKSSRSSSLGN------------- Wnk2_Hsap --HTAPPTGRRR-----------------KTSKSKLKAGKLLNPLVR------------- 17822_Tthe -----------I-----------------QQQQQQLN-QN---NILS------------- 8961_Tthe -----------H-----------------HDKKESAN-KS---QFQQ------------- WNK_Spur -----PLLLYQPNMYSMVPFPMQENFAPPGNFAPQGNF--APQGMWHPSSNLIPYNHFQG AqueK219_Aque --SIGSSTGQRP-----------------GYHPF-------------------------- WNK_e_Smoe -----------------------------------PG-TG---LYRY------------- WNK_a_Smoe ------------------------------------------------------------ WNK_d_Smoe ICERD--KASSR-----------------GVERSATT-SS---VLVH------------- WNK_c_Smoe ------------------------------------------------------------ WNK_b-2_Smoe --ELA--MCDDR-----------------GDKRQSFG-SS---EFQF------------- WNK_b-1_Smoe --ELA--MCDDR-----------------GDKRQSFG-SS---EFQF------------- GK075_Glam ------------------------------------------------------------ Wnk4_Hsap --S--------------------------------------------------------- Wnk3_Hsap ------------------------------------------------------------ C46C2.1_Cele --A----SLS--------------LPAS-PPPNT----------ETTKVNT--T------ CG7177_Dmel -------------------------PHQ-LPPMQTMG------AQ--QQMISQQ------ Wnk1_Mmus --K----SPQL---SGNLSGQSGT-SVL-HPQQTLH---PAGNTPETGHNQ--L------ Wnk2_Mmus --Q----LKVVASSTGHLSDSSRGPPTK-DPAHAS-------TPPGTKAVQ--T------ Wnk3_Mmus ------------------------------------------------------------ Wnk4_Mmus --S--------------------------------------------------------- Wnk1_Hsap --K----SPQL---SGNLSGQSAA-SVL-HPQQTLH---PPGNIPESGQNQ--L------ Wnk2_Hsap --Q----LKVVASSTGHLADSSRGPPAK-DPAQASVGLTADSTGLSGKAVQ--T------ 17822_Tthe --QNIPQT------Q-------------------------------------------NV 8961_Tthe --GILPQL------AQSESRDSSQ-SQAQQQMQQSY---PQPNYSHVNQNQ--MQNQQFT WNK_Spur VPF----THAPGSAFGGFRQGTTSPPTV--PGMSSMG------VPVQGGMV--T------ AqueK219_Aque ------------------HYYQGGPPLH-PPPHDTRD---------NGSLL--S------ WNK_e_Smoe --SP-K------------------------------------------------------ WNK_a_Smoe ------------------------------------------------------------ WNK_d_Smoe --HKQA------------------------------------------------------ WNK_c_Smoe ------------------------------------------------------------ WNK_b-2_Smoe --KEVP------------------------------------------------------ WNK_b-1_Smoe --KEVQ------------------------------------------------------ GK075_Glam ------------------------------------------------------------ Wnk4_Hsap ------------------------------------------------------------ Wnk3_Hsap -----INEL--E------------------------------------------------ C46C2.1_Cele ------------------------------------------------------------ CG7177_Dmel -----QHQLQMQSHMH-QQNVPGMYNQQTGARVAA------------------------- Wnk1_Mmus -----LQPL--KPSPSSDNLYSAFTSDGAI------------------------------ Wnk2_Mmus -----QQPCSVRASLS-TDICSGLASDGGGARGQGWTVYHPTSE---------------- Wnk3_Mmus ------------------------------------------------------------ Wnk4_Mmus ------------------------------------------------------------ Wnk1_Hsap -----LQPL--KPSPSSDNLYSAFTSDGAI------------------------------ Wnk2_Hsap -----QQPCSVRASLS-SDICSGLASDGGGARGQGWTVYHPTSE---------------- 17822_Tthe Q--QII-------EVQ-TQFIQ-SQS---------------------------------- 8961_Tthe QQIQTQ-------EIN-QLICNNVTQ---------------------------------- WNK_Spur -----YRPVAGVEMPG-QGAMPGAAPAMTGAQYQVPTTMHPRFSASNEMIPQQTYTNSQG AqueK219_Aque -----QQNNSSTSNLA-AAAAAGEASRHI-EAGRG-TPYYPTAP---------------- WNK_e_Smoe ------------------------------------------------------------ WNK_a_Smoe ------------------------------------------------------------ WNK_d_Smoe ------------------------------------------------------------ WNK_c_Smoe ------------------------------------------------------------ WNK_b-2_Smoe ------------------------------------------------------------ WNK_b-1_Smoe ------------------------------------------------------------ GK075_Glam ------------------------------------------------------------ Wnk4_Hsap --------------EPP--GP---------GI---------------M------------ Wnk3_Hsap ------------------------------------------------------------ C46C2.1_Cele --------------VIP--SD---------VL---------------A------------ CG7177_Dmel ---PQNFAGAVP--------------------NHLLQQSPLMASQQPAQP--MQHVMQPI Wnk1_Mmus ---------SVPSLSAP--GQ---------GT---------------S------------ Wnk2_Mmus -------RGAYKSSSKP--RA---------RF---------------L------------ Wnk3_Mmus ------------------------------------------------------------ Wnk4_Mmus --------------DLP--GP---------GI---------------M------------ Wnk1_Hsap ---------SVPSLSAP--GQ---------GT---------------S------------ Wnk2_Hsap -------RVTYKSSSKP--RA---------RF---------------L------------ 17822_Tthe ----------------P--PPQIGQQK---IQ---------------Q------------ 8961_Tthe ----------------HHQNSHHSHSL---II---------------Q------------ WNK_Spur LKRSVSYQ-----SVVP--QP---------N-----TGFQPAFFPNPNQPMGPPNPEAFM AqueK219_Aque -------IGPHSHIMPQ--EG---------LHLMAPGGMWLPPSDWPQ------------ WNK_e_Smoe -------------------APETDN-----DI---------------L------------ WNK_a_Smoe ------------------------------------------------------------ WNK_d_Smoe -------------------CSEGEIGLTTLEQ---------------Q------------ WNK_c_Smoe --------------------------KAALEA---------------I------------ WNK_b-2_Smoe -------------------ASKTSCGL---DV---------------Q------------ WNK_b-1_Smoe -------------------ASKTSCGL---DV---------------Q------------ GK075_Glam ------------------------------------------------------------ Wnk4_Hsap ------------------------------------------------------------ Wnk3_Hsap ------------------------------------------------------------ C46C2.1_Cele ------------------------------------------------------------ CG7177_Dmel ------------------------------------------------------------ Wnk1_Mmus ------------------------------------------------------------ Wnk2_Mmus SGP--------------------------------------------------------- Wnk3_Mmus ------------------------------------------------------------ Wnk4_Mmus ------------------------------------------------------------ Wnk1_Hsap ------------------------------------------------------------ Wnk2_Hsap SGP--------------------------------------------------------- 17822_Tthe ------------------------------------------------------------ 8961_Tthe ------------------------------------------------------------ WNK_Spur PRPGAGNAWMSSAGGAMQIMDMKDQQSIQNGINRSPEQLPRGIDNAGVTFPTQQVHPYPS AqueK219_Aque ------------------------------------------------------------ WNK_e_Smoe ------------------------------------------------------------ WNK_a_Smoe ------------------------------------------------------------ WNK_d_Smoe ------------------------------------------------------------ WNK_c_Smoe ------------------------------------------------------------ WNK_b-2_Smoe ------------------------------------------------------------ WNK_b-1_Smoe ------------------------------------------------------------ GK075_Glam ------------------------------------------------------------ Wnk4_Hsap ------------------------------------------RR---------------- Wnk3_Hsap ------------------------------------------------------------ C46C2.1_Cele ------------------------------------------TR---------------- CG7177_Dmel ------------------------------------------------------------ Wnk1_Mmus ------------------------------------------ST---------------- Wnk2_Mmus ---------------------------------VSVSI--SLKR---------------- Wnk3_Mmus ------------------------------------------------------------ Wnk4_Mmus ------------------------------------------RR---------------- Wnk1_Hsap ------------------------------------------ST---------------- Wnk2_Hsap ---------------------------------VSVSIWSALKR---------------- 17822_Tthe ------------------------------------------Q----------------- 8961_Tthe ------------------------------------------R----------------- WNK_Spur HVRTGSGTEKIDFTKRMVPMNSEATEAVTSKGYQA--------QTDLGQVERRLEEARPG AqueK219_Aque ------------------------------------------------------------ WNK_e_Smoe ------------------------------------------KK---------------- WNK_a_Smoe ------------------------------------------------------------ WNK_d_Smoe ------------------------------------------RK---------------- WNK_c_Smoe ------------------------------------------RR---------------- WNK_b-2_Smoe ------------------------------------------R----------------- WNK_b-1_Smoe ------------------------------------------R----------------- GK075_Glam ------------------------------------------------------------ Wnk4_Hsap --------------------------------------------N-----SLS------G Wnk3_Hsap --------------------------------------------N-----PLCV------ C46C2.1_Cele --------------------------------------------M-----TMS------Q CG7177_Dmel -------------------------------------------FN-----ATS------G Wnk1_Mmus --------------------------------------------N-----TVG------G Wnk2_Mmus --------------------------------------------L-----CLGKEHSSRS Wnk3_Mmus --------------------------------------------D-----ALGV------ Wnk4_Mmus --------------------------------------------N-----SLS------G Wnk1_Hsap --------------------------------------------N-----TVG------A Wnk2_Hsap --------------------------------------------L-----CLGKEHSSRS 17822_Tthe -----------------------------------------------QFTQNER-----V 8961_Tthe -----------------------------------------------SQPNQQ------T WNK_Spur GLSQPNYQSENTELHGQIDNRVAVDHPTTDPRPADNNTDVIPTDQ-----TVA------A AqueK219_Aque ------------------------------------------------------------ WNK_e_Smoe --------------------------------------------EK-LQRSIA------E WNK_a_Smoe ------------------------------------------------------------ WNK_d_Smoe --------------------------------------------EQLLQKSIA------E WNK_c_Smoe --------------------------------------------EFLSG----------- WNK_b-2_Smoe -----------------------------------------------RQKSMS------D WNK_b-1_Smoe -----------------------------------------------RQKSMS------D GK075_Glam ------------------------------------------------------------ Wnk4_Hsap S--S-------------TGSQEQ----RASKGVT-------------------------- Wnk3_Hsap --ES-------------NAASCQ--QSPASKKGMFTDDLHKLVDDWTKEAVGNS---LIK C46C2.1_Cele S--S-------------TKSSNVS------------------------------------ CG7177_Dmel EVT------EEPVSL----AATHPHLLPSDIQSDIKHNLDSLVNQLCNTRLGTN---QHQ Wnk1_Mmus TVSS-------------QAAQAQPPAMTSSRKGTFTDDLHKLVDNWARDAMNLS---GRR Wnk2_Mmus STSSLAP-GPEPGPQPTLHVQAQ-VNNSNNKKGTFTDDLHKLVDEWTTKTVGAA---QVK Wnk3_Mmus --ES-------------NTVSCQ--QSPASKKGMFTDDLHKLVDDWTRETVGHF---PSK Wnk4_Mmus S--S-------------TGSQEQ----RASKGVT-------------------------- Wnk1_Hsap TVNS-------------QAAQAQPPAMTSSRKGTFTDDLHKLVDNWARDAMNLS---GRR Wnk2_Hsap STSSLAP-GPEPGPQPALHVQAQ-VNNSNNKKGTFTDDLHKLVDEWTSKTVGAA---QLK 17822_Tthe V--Q-------------QQQ------ATAQVQQKLIQNNQQLIQ-NSQA-QQLT----QQ 8961_Tthe I--S-------------LNQNM---SIDNSQKGYLINNNQETNQ-ALQNICNLS----QQ WNK_Spur QLQT-----------PA--SQQQQQQQAGKRKGTFADDKFKNLADLSKPTAARPALDERK AqueK219_Aque -----YMHP------------HVPPAHFSSTNQAMMQGLHHSITPH-------------- WNK_e_Smoe L--E-------------ARTLE---GLS-KKNGYF------------------------- WNK_a_Smoe ------------------------------------------------------------ WNK_d_Smoe L--E-------------AKTLE---GLHHSRNGYLVSSKKA------------------- WNK_c_Smoe ------------------------------------------------------------ WNK_b-2_Smoe M--D-------------VKKSL---ALEA------------------------------- WNK_b-1_Smoe M--D-------------VKKSL---ALEA------------------------------- GK075_Glam ------------------------------------------------------------ Wnk4_Hsap ------------------------------------------------------------ Wnk3_Hsap ---------------PSLNQ---LKQSQHKLETEN-W----------NKVS--------- C46C2.1_Cele ------------------------------------------------------------ CG7177_Dmel ---------------R-LLL---LRQRQLIEEDEL-RLKHYVEYEKFQKA---------- Wnk1_Mmus ---------------GSKGH---M-------NYE-----------GPGMAR--------- Wnk2_Mmus ---------------PTLNQ---LKQTQKLHDMEA-S----------GDAR--------- Wnk3_Mmus ---------------PSLNQ---LKQSQQKSEAEN-W----------NKSC--------- Wnk4_Mmus ------------------------------------------------------------ Wnk1_Hsap ---------------GSKGH---M-------NYE-----------GPGMAR--------- Wnk2_Hsap ---------------PTLNQ---LKQTQKLQDMEA-Q----AGWAAPGEAR--------- 17822_Tthe ASNQQQQQQQN-QQTLSINQQNLQQQQQIQQQQLNNN----------NNNINMQQQPQQQ 8961_Tthe SSQSAQNDQSPMNQFLSFNP---IQNKQVNQEAQN-Q----------NNNSASRL----- WNK_Spur ---------------VSLND---LKRAQQQQDLH-------------------------- AqueK219_Aque -----------------------------------------ITHPPPPLSS--------- WNK_e_Smoe ------------------------------------------------------------ WNK_a_Smoe ------------------------------------------------------------ WNK_d_Smoe AS---------------------------------------------------------- WNK_c_Smoe ------------------------------------------------------------ WNK_b-2_Smoe ------------------------------------------------------------ WNK_b-1_Smoe ------------------------------------------------------------ GK075_Glam -----------------LQQ---FLDENM------------IDKSVVDPA---------- Wnk4_Hsap ------------------------------------------------------------ Wnk3_Hsap -------------------------ENTPSTMGYTSTWISSLSQIRGAVPTSLPQ----- C46C2.1_Cele --------------------------------------VSSRHRDNQSAPPRHHH----- CG7177_Dmel ------------------------------------LRQSISTNV----PANAAY----- Wnk1_Mmus ------------------------KFSAPG---Q--LCVPMTSNLGGSTPISAAS----- Wnk2_Mmus ------------------------ATSVP---------------------RAAVG----- Wnk3_Mmus -------------------------ESTPSTMGYTSNWISSLSQIRGAAPTSLPQ----- Wnk4_Mmus ------------------------------------------------------------ Wnk1_Hsap ------------------------KFSAPG---Q--LCISMTSNLGGSAPISAAS----- Wnk2_Hsap ------------------------AMTAP---------------------RAGVG----- 17822_Tthe QQTMLGQNTQVTNVNQQQQYQLQNQVQQQMTNQ--TNVQTNNANIQRSSPIKIEDEIKKI 8961_Tthe -------------------------------------------NLQIIENTN-------- WNK_Spur ------------------------------------------------------------ AqueK219_Aque ------------------------------------------------------H----- WNK_e_Smoe ------------------------------------------------------------ WNK_a_Smoe ------------------------------------------------------------ WNK_d_Smoe ------------------------------------------------------------ WNK_c_Smoe ------------------------------------------------------------ WNK_b-2_Smoe ------------------------------------------------------------ WNK_b-1_Smoe ------------------------------------------------------------ GK075_Glam ------------------------------------LDK--------------------- Wnk4_Hsap ------------------------------------------------------------ Wnk3_Hsap ----------------------------GLSLPSFPG---PLSSYGMPHVC-------QY C46C2.1_Cele ----------------------------HQPHPPHH---PHLQNHYHP--P-------QN CG7177_Dmel ----------------------------YSA---AAA---QLPTN---LAAPAAPS---- Wnk1_Mmus ----------------------------ATSLGHFTKSMCPPQQYGFP------------ Wnk2_Mmus ----------------------------ASCLAPAPG---PLSTTATPGATPALPVP--- Wnk3_Mmus ----------------------------GLPLPSFHG---PLASYGMPHVC-------QY Wnk4_Mmus ------------------------------------------------------------ Wnk1_Hsap ----------------------------ATSLGHFTKSMCPPQQYGFP------------ Wnk2_Hsap ----------------------------MPRLPPAPG---PLSTTVIPGAAPTLSVPTPD 17822_Tthe ILEIKLKLQRPQAVKIDRVNHDKVKDENEVRLLQRSLKLCSPQEQILENG---------H 8961_Tthe ------------------------------------------------------------ WNK_Spur ------------------------------------------------------------ AqueK219_Aque ----------------------------LPMQQTYPKSQQAQ----------------QE WNK_e_Smoe ------------------------------------------------------------ WNK_a_Smoe ------------------------------------------------------------ WNK_d_Smoe ------------------------------------------------------------ WNK_c_Smoe ------------------------------------------------------------ WNK_b-2_Smoe ------------------------------------------------------------ WNK_b-1_Smoe ------------------------------------------------------------ GK075_Glam ------------------------------------E---DAPKV---ISSDSLPAP--E Wnk4_Hsap ------------------------------------------------------------ Wnk3_Hsap NAVAGAGYPVQWVGISGTTQQS---VVIPAQSGGPFQPG--------------------- C46C2.1_Cele HTSAT-----------APCPS----------AMVQLQAVS-------------------- CG7177_Dmel ------------------------------------------------------------ Wnk1_Mmus ----PAPFGTQWSGTGGPAPQ----------PLGQFQPVG-------------------- Wnk2_Mmus ------------------------------------------------------------ Wnk3_Mmus NAVGAAGYPVQWVGISGPAQQS---VVLPTQSGGLFQPG--------------------- Wnk4_Mmus ------------------------------------------------------------ Wnk1_Hsap ----ATPFGAQWSGTGGPAPQ----------PLGQFQPVG-------------------- Wnk2_Hsap GALGTARRNQVWFGLRVPPTAC---CGHSTQPRGGQRV-G-------------------- 17822_Tthe FACNGAIENDLWKSISNELENQ---L-------AQIENKANLQQQKDQNKKKLIKEIQSQ 8961_Tthe ----------------TP----------------QFSPVPSKQ---------------NP WNK_Spur ------------------------------------------------------------ AqueK219_Aque VQTYQQPQQLQQEGTLNPVVV----------PAGMTSPTR-------------------- WNK_e_Smoe ------------------------------------------------------------ WNK_a_Smoe ------------------------------------------------------------ WNK_d_Smoe ------------------------------------VG---------------------- WNK_c_Smoe ------------------------------------------------------------ WNK_b-2_Smoe ------------------------------------MP---------------------- WNK_b-1_Smoe ------------------------------------MP---------------------- GK075_Glam A--------------------KVDPLGDNQN-VDEQF----------------------- Wnk4_Hsap ----------------------FAGDVGRM Wnk3_Hsap ---MNMQAFPTSSV----QN-PATIPPGPK C46C2.1_Cele --NNNVN-----PLHQ-PPHPVSSQIPPQA CG7177_Dmel -----------------SSN-PTSTSSANT Wnk1_Mmus --TASLQNFNISNLQKSISNP-PGSNLRTT Wnk2_Mmus -------------------IP-DPESEKPD Wnk3_Mmus ---MNLQSFPAPPV----QN-PASIPPGPK Wnk4_Mmus ----------------------FAGDIGRM Wnk1_Hsap --TASLQNFNISNLQKSISNP-PGSNLRTT Wnk2_Hsap ---SKT------------ASF-AASDPVRS 17822_Tthe QSKETMNNFE----SKMFSD-FSLTNNDLN 8961_Tthe ------HIPQ----SLNNDC-NLGTQGRNI WNK_Spur -------AS----AARPPSG-TTKADVPKT AqueK219_Aque --LEGT---------GDQ-DLTGTSVTQKR WNK_e_Smoe ---------------------AGLVKKAGV WNK_a_Smoe ------------------------VRNKSI WNK_d_Smoe ----------------I-NQ-QQQQQQQQP WNK_c_Smoe -------------------K-KENEAETSG WNK_b-2_Smoe ----------------RPEH-KGGHSLEVV WNK_b-1_Smoe ----------------IPEH-KGGHSLEVV GK075_Glam --TCAMQ-----E--LNGYL-MIHTDIIPE