CLUSTAL W (1.83) multiple sequence alignment SNF1A_Dmel YLLGATLGTGTFGKVK-------------------------------------------- AMPKa2_Mmus YVLGDTLGVGTFGKVK-------------------------------------------- AMPKa1_Mmus YILGDTLGVGTFGKVK-------------------------------------------- SNF1_Scer YQIVKTLGEGSFGKVK-------------------------------------------- AMPKa2_Hsap YVLGDTLGVGTFGKVK-------------------------------------------- AMPKa1_Hsap YILGDTLGVGTFGKVK-------------------------------------------- T01C8.1_Cele YILKETLGVGTFGKVK-------------------------------------------- Snf1_Ddis YRLDKTLGIGSFGKVK-------------------------------------------- 1110_Tthe YILGKKLGEGTFGKVK-------------------------------------------- 11543_Tthe FEIGQTIGRGTFGKVK-------------------------------------------- 20428_Tthe YLVGKTLGCGASGKVKREQFRLFKLTFFRGVQFTLLINQSSLSSENAKIFSKKSEFKNIF 21336_Tthe QITSETLGEGTFGKVK-------------------------------------------- 26498_Tthe YYVGKTIGRGTFGKVK-------------------------------------------- 4451_Tthe YIIGQNIGEGTFGKVK-------------------------------------------- 7432_Tthe NISDKTIGRGTFGKVK-------------------------------------------- 27742_Tthe YVLIKTLGEGAFGKVK-------------------------------------------- AMPK_Spur YVLGETIGMGTFGKVK-------------------------------------------- aak-1_Cele FVIKETIGKGAFGAVK-------------------------------------------- CC1G_10117_Ccin YTVIADIAEGTFGKVK-------------------------------------------- AqueK057_Aque YILGETLGTGTFGKVK-------------------------------------------- AMPK_f_Smoe YRTERRIGTGSFSTVV-------------------------------------------- AMPK_e_Smoe ------------------------------------------------------------ AMPK_a_Smoe YKMGKTLGIGSFGKVK-------------------------------------------- AMPK_d_Smoe YKMGKTLGIGSFGKVK-------------------------------------------- AMPK_b-1_Smoe YKLGKTLGIGSFGKVK-------------------------------------------- AMPK_b-2_Smoe YKLGKTLGIGSFGKVK-------------------------------------------- AMPK_c_Smoe YRTERRIGTGSFSTVI-------------------------------------------- GK014_Glam YLLGRQLGTGTFGKVR-------------------------------------------- GK013_Glam YITGKSLGVGTFGDVR-------------------------------------------- GK015_Glam YIIGKTIGEGSFSKVR-------------------------------------------- SNF1A_Dmel ----IGEHQITR-------------------------------VKVA-----------VK AMPKa2_Mmus ----IGEHQLTG-------------------------------HKVA-----------VK AMPKa1_Mmus ----VGKHELTG-------------------------------HKVA-----------VK SNF1_Scer ----LAYHTTTG-------------------------------QKVA-----------LK AMPKa2_Hsap ----IGEHQLTG-------------------------------HKVA-----------VK AMPKa1_Hsap ----VGKHELTG-------------------------------HKVA-----------VK T01C8.1_Cele ----VGIHETTQ-------------------------------YKVA-----------VK Snf1_Ddis ----LAEHIRTG-------------------------------VKVA-----------IK 1110_Tthe ----LATHILTG-------------------------------EKVA-----------IK 11543_Tthe ----LGIHKITN-------------------------------EKVA-----------VK 20428_Tthe CFIIVAKHDITG-------------------------------KEVA-----------IK 21336_Tthe ----VATHILTG-------------------------------EKVA-----------IK 26498_Tthe ----MGLHTYTMENIQLTFFTQVSINISKDNKQTLQLILNNENNKVA-----------IK 4451_Tthe ----LGTHIETR-------------------------------EKVA-----------IK 7432_Tthe ----LGVHTLTN-------------------------------EKVNIFSVNLSTAQTIK 27742_Tthe ----LATHILTG-------------------------------EYVA-----------IK AMPK_Spur ----MGEHLLTQ-------------------------------HKVA-----------IK aak-1_Cele ----RGTHIQTG-------------------------------YDVA-----------IK CC1G_10117_Ccin ----MAIHTVTG-------------------------------HKVA-----------MK AqueK057_Aque ----IADHDLTG-------------------------------HKVA-----------VK AMPK_f_Smoe ----LGEHRRSA-------------------------------RRVA-----------IK AMPK_e_Smoe ------------------------------------------------------------ AMPK_a_Smoe ----VAEHIPTG-------------------------------HKVA-----------IK AMPK_d_Smoe ----VAEHIPTG-------------------------------HKVA-----------IK AMPK_b-1_Smoe ----IGEHVLTG-------------------------------HKVA-----------IK AMPK_b-2_Smoe ----IGEHVLTG-------------------------------HKVA-----------IK AMPK_c_Smoe ----LGEHRRSA-------------------------------RRVA-----------IK GK014_Glam ----VATHIPTN-------------------------------CTVA-----------IK GK013_Glam ----LATHLITG-------------------------------ERVA-----------LK GK015_Glam ----LGTHVLTN-------------------------------ERIA-----------LK SNF1A_Dmel ILNRQKIKSLDVVGKIRREIQNLKLFRHPHIIKLYQ------------------------ AMPKa2_Mmus ILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ------------------------ AMPKa1_Mmus ILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQ------------------------ SNF1_Scer IINKKVLAKSDMQGRIEREISYLRLLRHPHIIKLYD------------------------ AMPKa2_Hsap ILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ------------------------ AMPKa1_Hsap ILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQ------------------------ T01C8.1_Cele ILNRQKIKSLDVVGKIRREIQNLSLFRHPHIIRLYQ------------------------ Snf1_Ddis ILNRTKIKNLKMDEKIRREIQNMKLFRHPHIIKLYE------------------------ 1110_Tthe ILEKDRIIDVSDVERVSREIHILKLLRHSNIIQLYE------------------------ 11543_Tthe VLDKDKLIDSADKKRLQREISILRKIRHPNIIQLYE------------------------ 20428_Tthe IINKKKMTVKKMSNKIKREIRLLRFFNHQNIIRLYE------------------------ 21336_Tthe ILEKEKIQDVSDVERVSREIHILKLLRHQNIIQLYE------------------------ 26498_Tthe ILDKDKIVDESDKIRVAREIQILRKIRHPNIIQLYEVNFQNLYFGIIQQFEQFIKYQDQI 4451_Tthe ILEKDKITEQADVERVAREIHILKILRHPNIIQLYE------------------------ 7432_Tthe ILEKRMIQGDQDMLSVQSEISILKSVNHPNISQLYQ------------------------ 27742_Tthe ILEKKKIIDVTDVERVQRELHILKMIRHPSLIQLYE------------------------ AMPK_Spur ILNRQKIKNLDVVSKIKREIQNMKLFRHPHIVKLYQ------------------------ aak-1_Cele ILNRGRMKGLGTVNKTRNEIDNLQKLTHPHITRLFR------------------------ CC1G_10117_Ccin YISKAVIQREKTKTRVRREFEYLRTLRHPHIIKLYE------------------------ AqueK057_Aque ILNRNKIQHLDVADKITREIQILKLFRHPHIIKLYE------------------------ AMPK_f_Smoe VMSRRNIIEGGMREKVAREVRTMALLRHPHIVRLYE------------------------ AMPK_e_Smoe ------------------------------------------------------------ AMPK_a_Smoe ILNRRKIKAMDMEEKVRREIKILRLFMHPHIIRLYE------------------------ AMPK_d_Smoe ILNRRKIKAMDMEEKVRREIKILRLFMHPHIIRLYE------------------------ AMPK_b-1_Smoe ILNRRKIRAMDMEEKVRREIKILRLFMHPHIIRLYE------------------------ AMPK_b-2_Smoe ILNRRKIRAMDMEEKVRREIKILRLFMHPHIIRLYE------------------------ AMPK_c_Smoe VMSRRNIIEGGMREKVAREVRTMALLRHPHIVRLYE------------------------ GK014_Glam ILSKSKITQMNMWSKVEREIMIMKMARHPHIINLYE------------------------ GK013_Glam VLDKSRIQCEDDFKRIVREIQVLKLLDHSNIVRLLE------------------------ GK015_Glam IIEKSKITEAADIERITREIQILKLLNHPNVIKLYE------------------------ SNF1A_Dmel --------VISTPSDIFMIMEYVSGGELFDYIV--K----------HGK----------- AMPKa2_Mmus --------VISTPTDFFMVMEYVSGGELFDYIC--K----------HGR----------- AMPKa1_Mmus --------VISTPSDIFMVMEYVSGGELFDYIC--K----------NGR----------- SNF1_Scer --------VIKSKDEIIMVIEYA-GNELFDYIV--Q----------RDK----------- AMPKa2_Hsap --------VISTPTDFFMVMEYVSGGELFDYIC--K----------HGR----------- AMPKa1_Hsap --------VISTPSDIFMVMEYVSGGELFDYIC--K----------NGRKSDVPGVVKTG T01C8.1_Cele --------VISTPSDIFMIMEHVSGGELFDYIV--K----------HGR----------- Snf1_Ddis --------VIETTTDIFMVMEYVTGGELFEYIV--K----------NGK----------- 1110_Tthe --------IIETPKQLFLIMEYASGGELFDYIV--A----------NQR----------- 11543_Tthe --------IIETPRQLYLFMEYAPNGELFDYIV--K----------RTR----------- 20428_Tthe --------VLDTNTDIFVVTEYISGGDLYDVIA--S----------KGK----------- 21336_Tthe --------IIETEKQLFLITEYASGGELFDYIV--K----------NTK----------- 26498_Tthe VFNLLLKQIIESQTQLFLITEYAPNNELFDFIV--KRNSQLFIKNKHNR----------- 4451_Tthe --------IIETQKQLYLIMEYAQGGELFDYIV--K----------NQK----------- 7432_Tthe --------IIETNDCLYLVLEYAQNGELFDFIV--R----------KRR----------- 27742_Tthe --------IIETPTHIFLVMEYCSKGEVFGYIQ--Q----------KQR----------- AMPK_Spur --------VISTPTDIFMVMEYVAGGELFDYIV--K----------HGK----------- aak-1_Cele --------VISTPSDIFLVMELVSGGELFSYIT--R----------KGA----------- CC1G_10117_Ccin --------VISTPTDIIFVLEYA-GGELFNYIV--A----------NGR----------- AqueK057_Aque --------VITTPKDIFMVMEYVSGGELFEYIV--K----------HGK----------- AMPK_f_Smoe --------VFETPRDVLIVMEYAERGDLYEYLLVQR----------NQR----------- AMPK_e_Smoe ------------------------------------------------------------ AMPK_a_Smoe --------VVETMNDIFVVMEYVKSGELFDYIV--E----------KGR----------- AMPK_d_Smoe --------VVETANDIFVVMEYVKSGELFDYIV--E----------KGR----------- AMPK_b-1_Smoe --------VVETSTDIFVVMEFVKSGELFDYIV--E----------NGR----------- AMPK_b-2_Smoe --------VVETSTDIFVVMEFVKSGELFDYIV--E----------NGR----------- AMPK_c_Smoe --------VFETPRDVLIVMEYAERGDLYEYLLVQR----------NQR----------- GK014_Glam --------VIYREDDIYLVMEYAEGGELFSYIV--K----------HKR----------- GK013_Glam --------VIDTPRHIYLVTEYVDNGELFNYVV--Q----------KQK----------- GK015_Glam --------IVDTPRHVYIVQEYMNNGELFDYIV--A----------KGR----------- SNF1A_Dmel ----LQEHQARRFFQQIISGVDYCHR-HMIVHRDLKPENLLLDH-NMHVKIADFGLSNM- AMPKa2_Mmus ----VEEVEARRLFQQILSAVDYCHR-HMVVHRDLKPENVLLDA-QMNAKIADFGLSNM- AMPKa1_Mmus ----LDEKESRRLFQQILSGVDYCHR-HMVVHRDLKPENVLLDA-HMNAKIADFGLSNM- SNF1_Scer ----MSEQEARRFFQQIISAVEYCHR-HKIVHRDLKPENLLLDE-HLNVKIADFGLSNI- AMPKa2_Hsap ----VEEMEARRLFQQILSAVDYCHR-HMVVHRDLKPENVLLDA-HMNAKIADFGLSNM- AMPKa1_Hsap STKELDEKESRRLFQQILSGVDYCHR-HMVVHRDLKPENVLLDA-HMNAKIADFGLSNM- T01C8.1_Cele ----LKTAEARRFFQQIISGVDYCHR-HMVVHRDLKPENLLLDE-QNNVKIADFGLSNI- Snf1_Ddis ----LLEDESRRLFQQMISGVDYCHH-HMVVHRDLKPENLLLDPINKCIKIADFGLSNM- 1110_Tthe ----VKEREAARFFQQIISGIEYIHK-LNIVHRDMKPENLLLNH-DKSIKIVDFGLSNT- 11543_Tthe ----LSERQASKFLQQIINGIEYMSK-IGVVHRDLKPENLLLDH-NYNIKIVDFGLSNT- 20428_Tthe ----LPEQEAKRYFKQIVAGVDYCHR-NLVAHRDLKLENILIDD-NNNIKIADFGLSNI- 21336_Tthe ----VQEREASVFFQQIISGVEYIHK-LKIVHRDMKPENLLLSY-NKRIKIVDFGLSNT- 26498_Tthe ----LNERQSARFLLQILSAVEYLHQ-NNIVHRDLKPENLLLDC-NNNIKVVDFGLSNM- 4451_Tthe ----INERESCKYIQQILSGVEYLHN-LNIAHRDLKPENLLLDH-QKNIKIVDFGLSNL- 7432_Tthe ----LTEQETCLVFAQILNALEYLHD-LGISHRDLKPENLLFDY-KYELKLVDFGLSKI- 27742_Tthe ----LDEVEASKFYQEILYGIEYLHK-LQVVHRDLKPENLLLDI-NHNIKIVDFGLSNM- AMPK_Spur ----LKEHEARRFFQQIISGVDYCHR-HMIVHRDLKPENLLLDP-NLHVKIADFGLSNM- aak-1_Cele ----LPIRESRRYFQQIISGVSYCHN-HMIVHRDLKPENLLLDA-NKNIKIADFGLSNY- CC1G_10117_Ccin ----MSEAQARRFFQQIISGIEYSHR-LKIVHRDLKPENVLLDD-DLNVKIADFGLSNE- AqueK057_Aque ----SSENESRAFFQQIISGVDYCHR-HKVVHRDLKPENLLLDS-NNKVKIADFGLSNL- AMPK_f_Smoe ----LEEAEARWFFQQLIAGVEYCHG-KSAIHRDIKVENLFLDS-QRHIKIGDFGLCNT- AMPK_e_Smoe -------------------------------HRDLKPENLLLDS-RCNVKIADFGLSNI- AMPK_a_Smoe ----LQEDEARR------------------------------------------------ AMPK_d_Smoe ----LQEDEARRFFQQIISGVEYCHR-NMVVHRDLKPENLLLDS-RCNVKIADFGLSNI- AMPK_b-1_Smoe ----LQEDEARCFFQQIISGVEYCHR-NMVVHRDLKPENLLLGS-KCSVKIADFGLSNI- AMPK_b-2_Smoe ----LQEDEARCFFQQIISGVEYCHR-NMVVHRDLKPENLLLGS-KCSVKIADFGLSNI- AMPK_c_Smoe ----LEEAEARWFFQQLITGVEYCHS-KSAIHRDIKVENLFLDS-QRHIKIGDFGLCNT- GK014_Glam ----LDSTTARKFFQQIISALSYLHIKVSVTHRDLKPENILLTK-NKLIKLSDFGLSNV- GK013_Glam ----LSEEEACKYFHQIVSALSYCHS-RKVCHRDMKLENVLLDS-SYNIKLIDFGLSNIL GK015_Glam ----LSEKEACRFLCQLLNGLHFLHS-RRIVHRDLKPENLLLTA-NNDIKIIDFGLSNI- SNF1A_Dmel MLDG-EFLRTSCGSPNYAAPEVISGKLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTL AMPKa2_Mmus MSDG-EFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTL AMPKa1_Mmus MSDG-EFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTL SNF1_Scer MTDG-NFLKTSCGSPNYAAPEVISGKLYAGPEVDVWSCGVILYVMLCRRLPFDDESIPVL AMPKa2_Hsap MSDG-EFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTL AMPKa1_Hsap MSDG-EFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTL T01C8.1_Cele MTDG-DFLRTSCGSPNYAAPEVISGKLYAGPEVDVWSCGVILYALLCGTLPFDDEHVPSL Snf1_Ddis MQDG-DFLKTSCGSPNYAAPEVISGKLYAGPEVDVWSCGVILYAFLCAKLPFDDESIPML 1110_Tthe YKKN-ELLKTACGSPCYAAPEMITGKRYNGLGVDIWSCGVILFALICGYLPFEDPVTANL 11543_Tthe YKDN-EKLKTACGSPCYAAPEMVAGKPYNGLQTDIWSSGVILYAMLCGYLPFEDQNTSVL 20428_Tthe MNDG-KYLSTSCGSPNYAAPEVISGKLYCGTEVDTWSCGVILFALLGGYLPFDEEVIPAL 21336_Tthe YKKN-ELLKTACGSPCYAAPEMIAGKRYLGLGVDIWSCGVILFALVCGYLPFEDPNTSNL 26498_Tthe YEDG-QTLKTACGSPCYAAPEMVSGKRYEGLKTDIWSCGIILYAMLCGYLPFEDSNTTDL 4451_Tthe YKEG-ELLKTACGSPCYAAPEMIQGKKYEGLCVDIWSTGIIMFALICGYLPFEDQNTSVL 7432_Tthe CQEADQQLYTCCGSPCYASPETISSQPYVGRYVDLWSCGIILFAMLCGYLPFDDDNQASL 27742_Tthe YKKN-ELLKTACGSPCYAAPEMIEGKKYESPQVDIWSSGVILFALLCGYLPFEDEDTRKL AMPK_Spur MTDG-EFLRTSCGSPNYAAPEVISGKLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTL aak-1_Cele MTDG-DLLSTACGSPNYAAPELISNKLYVGPEVDLWSCGVILYAMLCGTLPFDDQNVPTL CC1G_10117_Ccin ISDG-DFLTTSCGSPNYAAPEVIRGGVYAGPEIDVWSSGVILYVMLCGRLPFEDDDVQML AqueK057_Aque MKDG-EFLRTSCGSPNYAAPEVVSGKLYAGPEVDVWSCGIILYALLCGSLPFEDTNISML AMPK_f_Smoe MQEG-GFLRTSCGSTHYAAPELLLRRPYVGPEVDVWSCGVVLYVLLGGCYPFDDANTTTL AMPK_e_Smoe MRDG-HFLKTSCGSPNYAAPEVISGKLYAGPEVDVWSCGVILYALLCGSLPFDDENIPNL AMPK_a_Smoe ------------------------------------------------------------ AMPK_d_Smoe MRDG-HFLKTSCGSPNYAAPEVISGKLYAGPEVDVWSCGVILYALLCGSLPFDDENIPNL AMPK_b-1_Smoe MRDG-HFLKTSCGSPNYAAPEVISGKLYAGPEVDVWSCGVILYALLCGSLPFDDENIPNL AMPK_b-2_Smoe MRDG-HFLKTSCGSPNYAAPEVISGKLYAGPEVDVWSCGVILYALLCGSLPFDDENIPNL AMPK_c_Smoe MQEG-GFLRTSCGSTHYAAPELLLRRPYVGPEVDVWSCGVVLYVLLGGCYPFDDANTTTL GK014_Glam MSEG-EFLKTSCGSPNYASPEVVAGTLYIGPATDIWSAGCVLYTLLVGRLPFDDHYMPAL GK013_Glam MSDE-AKFKTACGSPSYASPEMLSGKKYHGPSIDVWAIGIILFAMICGHLPFDHDNTETL GK015_Glam FHD--TFMKTCCGSPAYAPPEMIQGKLYSGPSADLWSTGIILYAMLCGCLPFEGSTTQSL SNF1A_Dmel FRKIKSGIFPIPEYLNK-QVVNLVCQMLQVDPLKRANIEEIKKHEWF AMPKa2_Mmus FKKIRGGVFYIPDYLNR-SVATLLMHMLQVDPLKRATIKDIREHEWF AMPKa1_Mmus FKKICDGIFYTPQYLNP-SVISLLKHMLQVDPMKRAAIKDIREHEWF SNF1_Scer FKNISNGVYTLPKFLSP-GAAGLIKRMLIVNPLNRISIHEIMQDDWF AMPKa2_Hsap FKKIRGGVFYIPEYLNR-SVATLLMHMLQVDPLKRATIKDIREHEWF AMPKa1_Hsap FKKICDGIFYTPQYLNP-SVISLLKHMLQVDPMKRATIKDIREHEWF T01C8.1_Cele FRKIKSGVFPTPDFLER-PIVNLLHHMLCVDPMKRATIKDVIAHEWF Snf1_Ddis FKKIREGVFSIPDFVSP-SCADLIKKMLVVDPVKRITIHEIRNHPWF 1110_Tthe YKKITAGDFTVPKNVSN-EARDLLKSILNTDPQKRFTIEEIRNHPWC 11543_Tthe YKKIMNQDPVLPSFLSS-NSKGILSGILTKDPEKRYNIQDIRLHPFC 20428_Tthe YKKIKA-------FFSP-EAHDIIKRMLRPNPIERIKFHELRLHPWL 21336_Tthe YKKILAGDYQIPKFVSS-EGRDLIKNILTTDPTKRFTISDIRKHPWF 26498_Tthe YKKIINDPVKLPKFLTD-RSKSILNGILEKNPEKRLTIEAIRKHDFC 4451_Tthe YKKIVSGEFSIPRWVST-EAKDLLNCILNTDPVKRYKINDIRNHKWY 7432_Tthe FAKIISCEYYIPTDISP-EASYLIRGLLKKDPNQRLSIKDIKNSAFY 27742_Tthe YDKILKGKYGIPSHVSP-DAKDLIEKILTVDPEKRMKFDQIKAHKWF AMPK_Spur FRKIKGGHFTIPDHIERSQVKSLIQHMLQVDPLKRATIKDIREHDWF aak-1_Cele FAKIKSGRYTVPYSMEK-QAADLISTMLQVDPVKRADVKRIVNHSWF CC1G_10117_Ccin FHKISQGQFHCPSYLSK-DAQSLINSMLVVDPVKRATITDIINHPFF AqueK057_Aque FRKIKSGQFYIPHYISK-GASDLLTQMLQVNPVKRITLPQIKEHTWF AMPK_f_Smoe YTKILSGTFNFPLFVPD-GPRDLISRMLTVDPRARITVAEIKEHAWF AMPK_e_Smoe FKKIKTGLYTLPSHLSP-GAKDLIPRMLLVEPMKRMTIPEIRQHPWF AMPK_a_Smoe ----------------------------------------------F AMPK_d_Smoe FKKIKTGLYTLPSHLSP-GAKDLIPRMLLVEPMKRMTIPEIRQHPWF AMPK_b-1_Smoe FKKIKGGIYTLPSHLSS-GAKDLIPRMLLVDPMKRMTVAEIREHPWF AMPK_b-2_Smoe FKKIKGGIYTLPSHLSS-GAKDLIPRMLLVDPMKRMTVAEIREHPWF AMPK_c_Smoe YSKILSGTFNFPLFVPD-GPRDLISRMLTVDPRARITVAEIKEHAWF GK014_Glam FRKIKTGEYVIPDYVDS-GAADMLRGMMTVDVDKRFTIDIIRAHPWF GK013_Glam YKKIISGVFHIPDHVSP-EAADLISKILVVDPDKRITLDEITKHPWY GK015_Glam YIKILSGEFSTPSYLSQ-GAKDVLKALLTVNPDDRVTIEELITYPWI