CLUSTAL W (1.83) multiple sequence alignment BIKE_Hsap VTLEESLAEGGFSTVFLVRTH---------------GGIRCALKRMYVN-NMPDLNVCKR AAK1_Hsap VTVDEVLAEGGFAIVFLVRTS---------------NGMKCALKRMFVN-NEHDLQVCKR BIKE_Mmus VTLEESLAEGGFSTVFLVRTH---------------SGIRCALKRMYVN-NTPDLNICKR AAK1_Mmus VTVDEVLAEGGFALVFLVRTS---------------NGVKCALKRMFVN-NEHDLQVCKR sel-5_Cele VTIEKQIAEGGFAIVYVASDRK--------------N-NKFALKRQFTKDNEKQLEACCR DDB0229347_Ddis VTEVKLVAEGGFGFVYLVRDDY--------------N-NMYALKRMFIQ-ERERLEAMKN DDB0229350_Ddis ------IAEGGFSYVFLVKDSN--------------TSKHYALKRILIR-DEDELKGVKH Nak_Dmel VTVEDVLAEGGFAMVFLARGNGG---------G-SSSATKYALKRMYVN-NEHDLNVAKR AKL1_Scer VEVVNYLAEGGFAQIYVVKFLEYLNEFDNTASVPLKIGDVACLKRVLVQ-DENGLNEMRN ARK1_Scer VEIIKYLTSGGFAQVYSALINPP---------DPHSNSSVACLKRVIVP-DKPSLNTLRA PRK1_Scer AKIIKYLTSGGFAQVYTAEISPP---------DPYSNANIACLKRVIVP-HKQGLNTLRA AAK1_Spur ------------------------------------------------------------ AqueK170_Aque YIVEDVIAEGGYAIVLEVKCTA-------------GTNERLALKRVAVN-SEQDLYLCRQ BIKE_Hsap EITIMKELSGHKNIVGYLDCAVNSI-SD--NVWEVLILMEYCRAGQVVNQMNKKLQ--TG AAK1_Hsap EIQIMRDLSGHKNIVGYIDSSINNV-SSG-DVWEVLILMDFCRGGQVVNLMNQRLQ--TG BIKE_Mmus EITIMKELSGHKNIVGYLDCAVNSI-SD--NVWEVLILMEYCRAGQVVNQMNKKLQ--TG AAK1_Mmus EIQIMRDLSGHKNIVGYIDSSINNV-SSG-DVWEVLILMDFCRGGQVVNLMNQRLQ--TG sel-5_Cele EHSFLKQCIGHKNIVEFVDSYTNCL-GN--GIWECMLLTEYHQ-KNVLQLMNERISQNQY DDB0229347_Ddis EIDVMQKLRNNPNIVKLEGFKINEN-RNT-RETEVLMLMEYCSGGSVLDIMNARGEF-TR DDB0229350_Ddis EISIMKRLTKHKNIVKILDYHKVSD--K--NNTEMFILMEYCSGGHLVEIMQKRLSSGSK Nak_Dmel EIQIASNLSGHKNIIGYVDSSITPT-GN--GVCEVLLLMPYCKH-HMLAMMNARLH--VG AKL1_Scer EVEVMKKLKGAPNIVQYFDSNASRR-RDGVQGFEVLLLMELCPNKSLLDYMNQRLS--TK ARK1_Scer EVDAMRLLKNNRYVVSYIDSHAAKAMLHN-GSYEVFVLMEYCERGGLIDFMNTRLQ--NR PRK1_Scer EVDAMKLLRNNKHVVSYIDSHAARS-VNG-IAYEVFVLMEFCERGGLIDFMNTRLQ--NR AAK1_Spur ------------------------------------------------------------ AqueK170_Aque EIAILKALSDSPNSVTYLASQINKL-SR--EVYEVLILMQLYGGQTGLQLIRQYHGQGKR BIKE_Hsap FTEPEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLND--GGNYVLCDFGSATNKFL AAK1_Hsap FTENEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLHD--RGHYVLCDFGSATNKFQ BIKE_Mmus FTESEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLND--AGNYVLCDFGSATNKFL AAK1_Mmus FTENEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLHD--RGHYVLCDFGSATNKFQ sel-5_Cele LTNDEILSIFTDLCEAVSFIHNRPQPIIHRDLKVENVLISSHKPPHYVLCDFGSATTQIL DDB0229347_Ddis LEEREILAIFSDVCNGVLAMHQQQPPIAHRDLKIENVLYCE-HSNRYKLCDFGSSTIKTF DDB0229350_Ddis FTDQEILKIFQDICESVAYMHSQQPLIIHRDLKVENVLLDE-ESGIYKLCDFGSATEEIT Nak_Dmel FTEPEVLNIFCDIAEAVSRLHYCQTPIIHRDLKVENILQTD--AGNFVLCDFGSATAKTL AKL1_Scer LTEAEIVKIMYDVALSISQMHYLPVSLIHRDIKIENVLVDA--KNNFKLADFGSTSTCFP ARK1_Scer LHEFEILQIMSQVTQGVAAMHALQPPLIHRDIKIENVLISA--NNEYKLCDFGSVCGIIR PRK1_Scer LQESEILEIMSQTVQGITAMHALQPPLIHRDIKIENVLISH--DGLYKVCDFGSVSGVIR AAK1_Spur FTEQEVLRIFCNVCEAVSRLHHCQTPIIHRDLKVENILLHR--SGNYMLCDFGSATGRVL AqueK170_Aque LPEALILKIFTDVCLAVSRLHHRTKPIIHRDLKVTLLQM--------------------- : : :: *: : .: :* : ***:*: : BIKE_Hsap NPQ-KDGVNVVEEEIKKYTTLSYRAPEMINLYGGKPITTKADIWALGCLLYKLCFFTLPF AAK1_Hsap NPQ-TEGVNAVEDEIKKYTTLSYRAPEMVNLYSGKIITTKADIWALGCLLYKLCYFTLPF BIKE_Mmus NPQ-KDGVNVVEEEIKKYTTLSYRAPEMINLYGGKPITTKADIWALGCLLYKLCFFTLPF AAK1_Mmus NPQ-AEGVNAVEDEIKKYTTLSYRAPEMVNLYSGKIITTKADIWALGCLLYKLCYFTLPF sel-5_Cele SVE-KYGVEYVKSEVERNTTMCYRSPEMIDFYSGLEIGLKSDIWALGVLLYRLCFFCVPF DDB0229347_Ddis NT--ATERGKAEDDINMFTTLFYRAPEMVDLYRGQIIDEKVDVWALGCLLFKMAFYVDPF DDB0229350_Ddis RMKNKTEMQNAEDDISRHTTLQYRAPEIVDFYRSPVINEKIDIWALGCLLYKLLFYVTPF Nak_Dmel NPQ-QHGVTVVQEEIQKYTTLSYRAPEMIDLYGGKSITTKADIWALGCMLYKLCFFSLPF AKL1_Scer IVTTHQDIALLTQNIYVHTTPQYRSPEMIDLYRCLPINEKSDIWALGVFLYKLLFFTTPF ARK1_Scer PPRNSQELSYVQQDILKNTTAQYRSPEMIDTFRGLPIDEKSDIWALGIFLYKLCYYTTPF PRK1_Scer PPRNTQEFNYVQHDILTNTTAQYRSPEMIDLYRGLPIDEKSDIWALGVFLYKICYYTTPF AAK1_Spur DPK-VHSINDIKDEIEKYTTVSYRSPEMIDLYSEKTITTKADIWALGCMLYKLCFFTLPF AqueK170_Aque DPK-EVGVGECQDQLQKFTTLAYRAPEMVDLYSGYTISTKSDIWALGCLLYKFCFFDTPF :: ** **:**::: : * * *:**** :*::: :: ** BIKE_Hsap GES-QVAICDGNFTIPD-NSRYSRNIHCLIRFMLEPDPEHRPDIFQVS------------ AAK1_Hsap GES-QVAICDGNFTIPD-NSRYSQDMHCLIRYMLEPDPDKRPDIYQVS------------ BIKE_Mmus GES-QVAICDGSFTIPD-NSRYSHNVHCLIRFMLEPDPECRPDIFQVS------------ AAK1_Mmus GES-QVAICDGSFTIPD-NSRYSQDMHCLIRYMLEPDPDKRPDIYQVS------------ sel-5_Cele EES-PLAIQSVNYQFPS-VPNIPDEIKVLIYMLLDIDVNRRPSIYQTSV----------- DDB0229347_Ddis DGG-SLQIINNNYKIPD-NSKYSNNFHKLIQFILVADPTQRPS----------------- DDB0229350_Ddis EDSGSLGILNSNYTIPP-NHTHSNDLISLIKIMLNPDPINRPNIFEITNQL--------- Nak_Dmel GES-TLAIQNGQFSIPD-SSKYSKGMHQLIKYMLEPDMEKRPNIWQVCE----------- AKL1_Scer EMTGQFAILHSKYEFPV-N-KYSSKLINLIIIMLAENPNLRPNIYQVLYH---------- ARK1_Scer EKGGDLAILSGKFEFPL-YPNYSEQLKGLIRDILVQDPRHRPNVYQLLKR---------- PRK1_Scer EKSGEAGILHARYQYPS-FPQYSDRLKNLIRLMLMEAPSQRPNICQVLEE---------- AAK1_Spur GES-SLAIQSGNFTIPD-NTKYSREMHALIRYMLEVDAEKRPDIFQVSHVAFKAASSETP AqueK170_Aque GEQ-TLAIMRGTFSFPADASNYSNGLLGLIKYTLNTDPNKRPDIFQVS------------ * : * . . ** * **. BIKE_Hsap ------------------------------------------------------------ AAK1_Hsap ------------------------------------------------------------ BIKE_Mmus ------------------------------------------------------------ AAK1_Mmus ------------------------------------------------------------ sel-5_Cele ------------------------------------------------------------ DDB0229347_Ddis ------------------------------------------------------------ DDB0229350_Ddis ------------------------------------------------------------ Nak_Dmel ------------------------------------------------------------ AKL1_Scer ------------------------------------------------------------ ARK1_Scer ------------------------------------------------------------ PRK1_Scer ------------------------------------------------------------ AAK1_Spur IQNLHKSPVPDGNKLPLPLTESEQRQQHSRSKTNNQNRTPAGPMEVSTSVTPRQRPKASQ AqueK170_Aque ------------------------------------------------------------ BIKE_Hsap ------------------------------------------------------------ AAK1_Hsap ------------------------------------------------------------ BIKE_Mmus ------------------------------------------------------------ AAK1_Mmus ------------------------------------------------------------ sel-5_Cele ------------------------------------------------------------ DDB0229347_Ddis ------------------------------------------------------------ DDB0229350_Ddis ------------------------------------------------------------ Nak_Dmel ------------------------------------------------------------ AKL1_Scer ------------------------------------------------------------ ARK1_Scer ------------------------------------------------------------ PRK1_Scer ------------------------------------------------------------ AAK1_Spur QGVAPAAGGISLPTPSSITRQRSSKQGQPPTTGPTVAAAAQRLSPPQVQAQQAIQQQQQQ AqueK170_Aque ------------------------------------------------------------ BIKE_Hsap ---------------YF AAK1_Hsap ---------------YF BIKE_Mmus ---------------YF AAK1_Mmus ---------------YF sel-5_Cele ----------------L DDB0229347_Ddis ----------------I DDB0229350_Ddis ---------NLLRNQQP Nak_Dmel --------------VAF AKL1_Scer --------------LCE ARK1_Scer --------------ISI PRK1_Scer -------------VSRL AAK1_Spur QQQQQQQQQQLLQEQQL AqueK170_Aque ---------------WV