CLUSTAL W (1.83) multiple sequence alignment cdc2_Dmel FEKIEKIGEGTYGVVYKGRN-RLTGQIVAMKKIRLE-SD---DEGVPSTAIREISLLKEL CDC2_Mmus YIKIEKIGEGTYGVVYKGRH-RVTGQIVAMKKIRLE-SE---EEGVPSTAIREISLLKEL K03E5.3_Cele FCSLRRIGEGTYGVVFKAIH-VRDNVKCALKMIRTD-RD---EEGIPSTCLREISCIKDL cdk-1_Cele FTKLEKIGEGTYGVVYKGKN-RRTNAMVAMKKIRLE-SE---DEGVPSTAVREISLLKEL CDC2_Hsap YTKIEKIGEGTYGVVYKGRH-KTTGQVVAMKKIRLE-SE---EEGVPSTAIREISLLKEL 21071_Tthe YEVLNVIGKGTYGEVFRARD-QETHEIVALKKTITK-LE---NDGIPSSALREISLLKEI 21599_Tthe YEKLLKVGEGTYGEVYKAKD-IQSSEIVALKKIKLE-NE---DEGVPSTALREISILKEL 23583_Tthe YLRIKKINEGSFGKIILCELVDQKGQYCVLKKFKVT-Q-Q---SAIDELSIKEIYYMKKL 25533_Tthe FKCLQKIGEGTYGIVYKGFD-TQTNTQVAIKKVKLD-QE---QEGIPQSALREICILKDL 25907_Tthe YVQLEKLGEGTYGVVFKAQD-MQTQQLVAIKQIRIDPNE---DEGVPSTTLREISILKKL 26482_Tthe ----------------------------------------------PTSILRELSYLQAL 6129_Tthe FQKIKMLGEGTYGHVTKCQD-KQTKEVVAVKKIKLEIFQ---GDGFPSSSMREISTLKKM 6298_Tthe YQKIKKIGEGTYGKVFQAKD-LKTDQIVALKKVKND-YEEIGDEGIPSTALREISCLKAL 9560_Tthe YQRTEKIGEGTYGIVYKAID-MQTNDIIALKKIRLE-HE---DEGVPSTAIREISLLKEI CDC2_Spur FMKIEKLGEGTYGVVYKGKH-KRTGKIVALKKIRLE-SE---EEGVPSTAIREISLLKEL n1179_Tthe FTQIHQLGEGTFGKVYKAQD-KKNNEIVAVKQVKIH-DE---REGFPVTSVREIKLLSEL CC1G_02703_Ccin ---------GTYGVVYKARD-TSTNTIVALKKIRLE-AE---DEGVPSTAIREISLLKEL AqueK094_Aque YTKLEKIGEGTYGVVYKARH-KVTGKTVALKKIRLE-NE---EEGVPSTAIREISILKEV CDC2-2_Smoe YEKVEKIGEGTYGVVYKARD-RITNETIALKKIRLD-QE---DEGVPSTAIREISLLKEM CDC2-1_Smoe YEKVEKIGEGTYGVVYKARD-RITNETIALKKIRLD-QE---DEGVPSTAIREISLLKEM GK021_Glam TDLVTLIGSGTYGDVYRCQH-KQTKTWYAIKRIKEG-KES--KMGLTGDKFMEILAFREL GK020_Glam YRRITKLGEGTYGEVYKAID-TVTNETVAIKRIRLE-HE---EEGVPGTAIREVSLLKEL GK022_Glam YEFISQIGEGTYGTVSKCS---LHGQLLAVKRIKMD-SS---SKGVPATTLREVAILKAL . *: : : cdc2_Dmel K----------------HENIVCLEDVLME----------------ENRIYLIFEFLSMD CDC2_Mmus R----------------HPNIVSLQDVLMQ----------------DSRLYLIFEFLSMD K03E5.3_Cele Q----------------HDNIVTLFDIIYASHFLNYNNIFFEKFSSNSKLYMVFEFIDRD cdk-1_Cele Q----------------HPNVVGLEAVIMQ----------------ENRLFLIFEFLSFD CDC2_Hsap R----------------HPNIVSLQDVLMQ----------------DSRLYLIFEFLSMD 21071_Tthe N----------------HENVVVLKDIIIQ----------------NNLLYLVFEFCESD 21599_Tthe Q---------------PHPNIVCMHEVIYQP--------------QEKKLYLVFEFVDQD 23583_Tthe D----------------HPNLVKSDDIFKIK--------------KSYNGQDFFEQLYMH 25533_Tthe S---------------DHQNIVKLRDVIYQI--------------EESKLFLVFEYVDYD 25907_Tthe K----------------HKNIVKLLDVYVFP--------------EAQKVSLVFEYYPQD 26482_Tthe D----------------HPNITKIHEVDIK----------------NVIVQIVTKRQEYN 6129_Tthe K----------------HENIVILKDVQFQF--------------DENSLLMVFECLECD 6298_Tthe D----------------HPNVVKLVDVVYIM--------------KKNKLYLVFEYIDYD 9560_Tthe D----------------HPNVIKLRDLVYG----------------ENKLYLIFDYLDHD CDC2_Spur Y----------------HPNIVMLEDVLME----------------PNRLYLVFEYLTMD n1179_Tthe Q---------------NHPNIVQFKEVVVGQ--------------NQNSIFLIFEYCQMD CC1G_02703_Ccin K----------------DDNIVKLLDIVHA----------------DQKLYLVFEFLDVD AqueK094_Aque Q----------------HTNVVKLEDIIHQ----------------DLKLYLVFEFMCMD CDC2-2_Smoe Q----------------HGNIVRLQDVVHC----------------EKKLYLVFEYLDLD CDC2-1_Smoe Q----------------HGNIVRLQDVVHC----------------EKKLYLVFEYLDLD GK021_Glam S----------------HPNILSCKSIFFH----------------GARLCFALELCNTS GK020_Glam Q----------------HRNIIELKSVIHH----------------NHRLHLIFEYAEND GK022_Glam NAKQRELVEQGKLESLSQANVVNLLDVVYD----------------LSNIFLVFEYCHVD . *: : . cdc2_Dmel LKKYMDSLPV----------D--KHMESELVRSYLYQITSAILFCHRRRVLHRDLKPQNL CDC2_Mmus LKKYLDSIPP----------G--QFMDSSLVKSYLHQILQGIVFCHSRRVLHRDLKPQNL K03E5.3_Cele LKNLLEMLEP----------T-NSVLPPNYVKSFMWQLLSALSYCHLRRIVHRDLKPQNI cdk-1_Cele LKRYMDQLGK----------D--EYLPLETLKSYTFQILQAMCFCHQRRVIHRDLKPQNL CDC2_Hsap LKKYLDSIPP----------G--QYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNL 21071_Tthe LKKFLDSK---------------TKVAGQFLDALTIKIIRGVAACHTRRIMHRDLKPQNI 21599_Tthe LKKFLDQYRK----------DKKLQLRPYQIKLMMYQILNGLNFCHSRRIIHRDLKPQNI 23583_Tthe LPYYLEMSEV-----------PRENLSVEAIKILIKQLIEAVHFLHQKKIIHRDIKPSNI 25533_Tthe LKKYLETMK---------------HLTQHDIKLIMYQLLNGLDFCHQRRIIHRDIKPQNI 25907_Tthe LRGYLKQLQQ----------KNQKEIPLSFYQNQFRQIIEGVDYCHSQGILHRDLKPQNI 26482_Tthe LKEYTRRYISQVQDDSKGLTRPQYKIPLIKVKEIAYQILEGLNYLHHQGIMHRNLKIDNI 6129_Tthe LKQYLENEF---------------PIQPIKIKQIMKQILQGVDYCHQMQIMHRDLKPQNI 6298_Tthe LKAYQKKIG---------------KIPEQTVKSYMHQILKGIEHCHSRRIFHRDLKPQNI 9560_Tthe LKKYLELN--------------GGPLPPAVVKDYLFQLILGIAVCHANRIVHRDLKPQNI CDC2_Spur LKKYMESLK-----------G--KQMDPALVKSYLHQMVDGILFCHSRRILHRDLKPQNL n1179_Tthe IANLIFRMDQ----------E-REYFSESEIKCIILQLLNGVQHMHKQYQMHRDIKLSNV CC1G_02703_Ccin LKRFIETGNQ----------N-RSPITPALVKKFTHQLNSGLLYCHSHRILHRDLKPQNL AqueK094_Aque LKKYLDSLPA----------G--KFMEPDLVKSYTYQILKGIVFCHGRRIIHRDLKPQNL CDC2-2_Smoe LKKHMDNSPD-------------FAKSPRMIKTFLYQMIRGLAYCHSHRVLHRDLKPQNL CDC2-1_Smoe LKKHMDNSPD-------------FAKSPRMIKTFLYQMIRGLAYCHSHRVLHRDLKPQNL GK021_Glam LKSILNSG---------------HSLTAEDRRTAYYQILLGLEYLHRNHISHFDLKPDNI GK020_Glam LKKYMDKNP---------------DVSMRVIKSFLYQLINGVNFCHSRRCLHRDLKPQNL GK022_Glam LDQYLKH----------------NVLSPYQIKKFMYQLLQGLSLVHKNEILHRDIKPNNI : :: .: * * ::* .*: cdc2_Dmel LIDKS----------------------GLIKVADFGLGRS---FGIP-VRIYTH------ CDC2_Mmus LIDDK----------------------GTIKLADFGLARA---FGIP-IRVYTH------ K03E5.3_Cele LVSDS----------------------GVIKIADFGLARN---FSFP-SRNYTH------ cdk-1_Cele LVDNN----------------------GAIKLADFGLARA---IGIP-IRVYTH------ CDC2_Hsap LIDDK----------------------GTIKLADFGLARA---FGIP-IRVYTH------ 21071_Tthe LIDKN----------------------------DFGLSRT---FCMP-IRPYTK------ 21599_Tthe LIDAK----------------------GNIKIADFGLARA---FGVP-IKTLTH------ 23583_Tthe FLDKT----------------------GKLLLGDMGISRD---FPENKDQELTG------ 25533_Tthe LIDKA----------------------GNVKIADFGLAKT---FQVP-SKTLTH------ 25907_Tthe LVSST----------------------GEIKIADFGLARA---FNYP-LKELTK------ 26482_Tthe LLDK-----------------------DVVKISDFGLSRL---VSIP-HIPYTPEDPKER 6129_Tthe LVSTKA------------------NNTMSVKISDFGLAKT---FTTP-LDKYTK------ 6298_Tthe LVNNK----------------------GDIKIADFGLGKI---FGIP-LNTITH------ 9560_Tthe LINKK----------------------GSVQLADFGLARA---FGLP-LKTYTH------ CDC2_Spur LIDNN----------------------GTIKLADFGLARA---FGIP-VRVYTH------ n1179_Tthe LINDK----------------------GVVKIADFGLARE---YNKP-NKPYTP------ CC1G_02703_Ccin LIDKH----------------------NNLKLADFGLARA---FGIP-MRTYTH------ AqueK094_Aque LIDNN----------------------GGIKIADFGLGRA---FGIP-VRAYTH------ CDC2-2_Smoe LIDRR---------------------TNALKLADFGLARA---FGIP-VRTFTH------ CDC2-1_Smoe LIDRR---------------------TNALKLADFGLARA---FGIP-VRTFTH------ GK021_Glam LIKDNN-------------------GSSVFKITDFGLSLITGRFRGP-SIVYTG------ GK020_Glam LLSVSDA-----------------SETPVLKIGDFGLARA---FGIP-IRQFTH------ GK022_Glam LLAFRGDAGEQLAANASVTTPNPDADNCVLKITDFGLARS---YGIN-VTSISA------ :: *:*:. : cdc2_Dmel -----EI--VTLWYRAPEVLLGSPRYSCPVDIWSIGCIFAEMA--TR-KPLFQGDSEIDQ CDC2_Mmus -----EV--VTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELA--TK-KPLFHGDSEIDQ K03E5.3_Cele -----EV--VTLWYRPPEILLGSQRYSTSLDMWSLGCIFSEIA--SN-KPLFPGECEISQ cdk-1_Cele -----EV--VTLWYRAPEILMGAQRYSMGVDMWSIGCIFAEMA--TK-KPLFQGDSEIDE CDC2_Hsap -----EV--VTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELA--TK-KPLFHGDSEIDQ 21071_Tthe -----EV--VTLWYRPPEILLGALDYCTPIDMWSVGCIM--------------------- 21599_Tthe -----EV--ETLWYRAPEILLGQKAYSLGVDIWSLGCIFHEMV--EK-RALFMGDSEIDQ 23583_Tthe -----NT--ITRLYRPPEILFGCKKYNETVDLWSLGCTIAEFFMDHK-KYFFQGKSEIDQ 25533_Tthe -----EV--ETLWYRPPEILLGVKTYSLAIDMWSIGCVFYELM--EK-KPLFISDSEIEA 25907_Tthe -----DI--VTLWYRSTELLLGESQYDIAIDMWSVGCILAEFV--TF-KPLFMGDSQIDQ 26482_Tthe ERSGREA--RRLWYRAPELLLRKSIYTFEIDMWSFGCLLAEIV--LN-EPLFAGDSEIEQ 6129_Tthe -----EI--ATLWYRAPEVMLGDEHYSITIDIWAVGCIFIELI--TK-RPPFHAQSQIDQ 6298_Tthe -----EV--ETLWYRAPEILLGDKLYSLPVDVWSIGCIFAELI--IG-HPLFHGDSEIDQ 9560_Tthe -----EV--VTLWYRPPEILLGQKQYSTPVDIWSIGCIFSEMA--QK-IPLFIGDSEIDQ CDC2_Spur -----EV--VTLWYRAPEVLLGSTRYACPIDMWSLGCIFAEMV--TK-RPLFHGDSEIDQ n1179_Tthe -----KV--VTLWYRSPELLLEMEQYTTSIDIW--------------------------- CC1G_02703_Ccin -----EV--VTLWYRAPEVLLGSRHYSTAIDMWSVGCIFAEMA--MQGAPLFPGDSEIDQ AqueK094_Aque -----EV--VTLWYRAPEVLLGCPRYSCPLDIWSIGCIFAEMS--NK-KPFFQGDSEIDQ CDC2-2_Smoe -----EV--VTLWYRAPEILLGSRHYSTPVDMWSVGCIFAEMI--NQ-RPLFPGDSEIDE CDC2-1_Smoe -----EV--VTLWYRAPEILLGSRHYSTPVDMWSVGCIFAEMI--NQ-RPLFPGDSEIDE GK021_Glam -----PGFRWTPIYRPPEVFGSTLEVGQSSDMWSIGLTFFEMI--IQ-TAVIQAE-ESRI GK020_Glam -----EI--ITLWYRPPEILLGSRHYSTSVDIWSIACIWAEML--MK-TPLFPGDSEIDQ GK022_Glam -----NV--VSLWYRAPELVLASKTYSTAVDMWSMGCIMYFLA--NK-RALFQVRKDADL **..*:. *:* cdc2_Dmel LFRMFRILKTPTEDIWPGVTSLPDYKNTFPCWSTNQLTNQ-------------------- CDC2_Mmus LFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASH-------------------- K03E5.3_Cele LFKIFEIVGTPNIKSWPGVDSFPHYKAVFPQWPV-NLKKLE-ET---------------- cdk-1_Cele LFRIFRVLGTPTELEWNGVESLPDYKATFPKWRENFLRDKF-YD---------------- CDC2_Hsap LFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASH-------------------- 21071_Tthe ------ILGTPTENDWPGIKDLTDYKPTFPRFRPQKLSEMI-ENIY-------------- 21599_Tthe IFKIFQYHGTPTEQTWPALKECPYFKPIYPRFKTADPKTYF-K----------------- 23583_Tthe LCKVFEIRGSANEQNWPGCTELPYYM-DFGELNQKDLSSL-------------------- 25533_Tthe IFKIFQFHGTPNSETFQGLEDYPYFKSTFPRFHAQDPFIVF-K----------------- 25907_Tthe LFKIFQFSGTPNGVIWPNVKKYIDFKQTFPKFLPSNTLRID-PRF--------------- 26482_Tthe LFKVFKFIGSPDSETLMSMCDNPDYQQTFPKWKMINLSHIC-EQNQSEEFKQLKTTMIPN 6129_Tthe LFQIFQIFGTPNEQTYPGISKLPDYNEKFPKFQAQGIQKLL-PS---------------- 6298_Tthe IFKIFQFFGTPKSSKLEGTYNLKYWSNLFPRFKSQKDEILK-PI---------------- 9560_Tthe IFKIFRIMGTPSESTWPGVTQLPDFKNTFPRWNPIPLQKQ-------------------- CDC2_Spur LFRIFRTLGTPTDDIWPGVTQLQDYKSTFPMWTKPNIKGA-------------------- n1179_Tthe ------------------------------------------------------------ CC1G_02703_Ccin IFKIFRLLGTPNEDIWPGVSTLPDYKPTFPNWSRQDLAKA-------------------- AqueK094_Aque LFRIFRILGTPSDAIWPSVTTMPNFKSTFPKWTGKSLSQL-------------------- CDC2-2_Smoe LFKIFRILGTPNEETWPGVTSLPDFKSAFPKWLPKDLATL-------------------- CDC2-1_Smoe LFKIFRILGTPNEETWPGVTSLPDFKSAFPKWLPKDLATL-------------------- GK021_Glam PAKIADLLGRLPNDTDPGVTD---WHGSFINLCGKDYSPPT-QPYM-------------- GK020_Glam LFKIFEVLGLPDDTTWPGVTALPDWKQSFPKFRGKTLKRV-------------------- GK022_Glam LQLAFSYFYVDS-SSISDLISLPNWNMYVGENQVIDLAALNAPG-R-------------- cdc2_Dmel -----------LK-NLDANGIDLIQKMLIYDPVHRISAKDILEHPYF CDC2_Mmus -----------VK-NLDENGLDLLSKMLVYDPAKRISGKMALKHPYF K03E5.3_Cele -------------SCLTGNGLDVLREILRYPPERRLTAKGALSHRYF cdk-1_Cele -------KKTGKH-LLDDTAFSLLEGLLIYDPSLRLNAKKALVHPYF CDC2_Hsap -----------VK-NLDENGLDLLSKMLIYDPAKRISGKMALNHPYF 21071_Tthe ------KKYNQN-SEVDIAAVDLLQRLLCYDPIKRITAKSALNHIKI 21599_Tthe --------------NFCDKGFDLIQQMIALDPAKRISVKDALRHPYF 23583_Tthe -----------LP-KAPKECIEIIDSLLQLCPQKRAKIEDIIQNKWL 25533_Tthe --------------NLENDARDLLMQMIALNPLDRISVKQALLHPYF 25907_Tthe -----------KE-QIRNEGIELIESLLQIVPEKRLNSDEALKAPFF 26482_Tthe RQNGFQKLKNLGT-ILGMQGMQLLNSLLQLNPYKRISSQEALNHPFF 6129_Tthe -------------NFNDPEALDLLSNLLVLDPSRRIFSKEALKHPYF 6298_Tthe -------------IETDPQAADLLVKLIDIEPAKRISVSQALKHPYF 9560_Tthe -----------CP-NICPKGIDLLTKMLQLDPTKRITAEEALDHPYF CDC2_Spur -----------VK-GMDEGGLDLLEQMLIYDPAKRITAKASMRHPYF n1179_Tthe ----------------------------------------------- CC1G_02703_Ccin -----------VP-TLDEAGIDMLKRTLTYDSAKRLSAKRALVHPYF AqueK094_Aque -----------CP-HLDSIGCDLLMQMVIYNPGKRISAKRAMEHPYF CDC2-2_Smoe -----------VP-GLEHAGVDLLSKMLCLDPSSRITARAALEHDYF CDC2-1_Smoe -----------VP-GLEHAGVDLLSKMLCLDPSSRITARAALEHDYF GK021_Glam ------HTLFER-HGVRPEEKQFIAKFLQYSPEARITAADALQDPFL GK020_Glam -----------LGALLDDEGLDLLTAMLEMDPVKRISAKNALEHPYF GK022_Glam ------KPREVDI-NIDDVGKDLFYKLLMLNPSKRISCDEALQHPWF