CLUSTAL W (1.83) multiple sequence alignment Cdk5_Dmel YDKMEKIGEGTYGTVFKGRNRDTMEIVALKRVRLDEDDEGVPSSALREICLLKELKHKNI CDK5_Mmus YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI cdk-5_Cele YDKMEKIGEGTYGTVFKARNKNSGEIVALKRVRLDDDDEGVPSSALREICILRELKHRNV CDK5_Hsap YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI Cdk5_Ddis YSKIEKLGEGTYGIVYKAKNRETGEIVALKRIRLDSEDEGVPCTAIREISLLKELKHPNI PHO85_Scer FKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDS-EEGTPSTAIREISLMKELKHENI 9119_Tthe YEKLNKLGEGTYGVVYKAREKTTKELYALKKIRLESEDEGIPSTAIREISLLKELQHPNV CDK5_Spur ------------------------------------------------------------ CC1G_03767_Ccin YIQLEKLGEGTYATVYKGRSRTTNEIVALKEIHLDA-EEGTPSTAIREISLMKELKHVNI AqueK097_Aque YERLEKIGEGTYGTVFKAKEKESGEIVALKIVRLDEDDEGVPSAALREICLLKELKHKNI GK023_Glam YERIQGLGEGTYGVVFKAKDKETGQIVALKRIRLENADEGIPATAIREIAILKEMKHKNV Cdk5_Dmel VRLIDVLHSDKKLTLVFEHCDQDLKKYFDSLN-----GEIDMAVCRSFMLQLLRGLAFCH CDK5_Mmus VRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCN-----GDLDPEIVKSFLFQLLKGLGFCH cdk-5_Cele VRLYDVVHSENKLTLVFEYCDQDLKKFFDSLN-----GYMDAQTARSLMLQLLRGLSFCH CDK5_Hsap VRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCN-----GDLDPEIVKSFLFQLLKGLGFCH Cdk5_Ddis VRLHDVIHTERKLTLVFEYLDQDLKKYLDECG-----GEISKPTIKSFMYQLLKGVAFCH PHO85_Scer VRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCH 9119_Tthe VRLHDVIHSNKKLVLVFEFVDQDLKKFMNNFKD----KGLDPHIIKSLLYQLLKGIEVCH CDK5_Spur ----------------------------------------------SFMYQLLRGLAFCH CC1G_03767_Ccin VRLHDVIHTETKLVLIFEYCEQDLKKYMDQHGER---GALEPEVVRSFMYQLLKGTAFCH AqueK097_Aque VRLTDVLHKNLKLTMVFEYIDQDLKKYFDVSG-----GIISPQVVQSFFFQLLQGLAFCH GK023_Glam VDLLSVIHTEAKLTLVFEYLDMDLKKYIDSKQ-----GKLTPKEVKSFMGQLMTGLTYIH : **: * * Cdk5_Dmel SHNVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVKCYSAEVVTLWYRPPDVLFGAKL CDK5_Mmus SRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKL cdk-5_Cele AHHVLHRDLKPQNLLINTNGTLKLADFGLARAFGVPVRCFSAEVVTLWYRPPDVLFGAKL CDK5_Hsap SRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKL Cdk5_Ddis DHRVLHRDLKPQNLLINRKGELKLADFGLARAFGIPVRTYSHEVVTLWYRAPDVLMGSRK PHO85_Scer ENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSRT 9119_Tthe KNKILHRDLKPQNLLISKECILKLADFGLARASGIPVKNYTHEVVTLWYRPPDVLLGSKH CDK5_Spur SHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKV CC1G_03767_Ccin ENQVLHRDLKPQNLLINRKGELKLGDFGLARAFGVPVNTFSNEVVTLWYRAPDVLLGSRT AqueK097_Aque YNNILHRDLKPQNILISKKGDLKLADFGLARAFGIPVRLFSAEVVTLWYRPPDVLMGAQV GK023_Glam NKRVLHRDLKPQNLLVTSSGLLKLADFGLARGSGIPVRSYTHEVVTLWYRCPSVLLGCRK ..:*********:*:. ***.******. *:**. :: ******** *.**:*.: Cdk5_Dmel YTTSIDMWSAGCILAELADAGRPLFPGSDVLDQLMKIFRVLGTPNEDSWPGVSH-LSDYV CDK5_Mmus YSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPAMTK-LPDYK cdk-5_Cele YNTSIDMWSAGCIFAEISNAGRPLFPGADVDDQLKRIFKQLGSPSEDNWPSITQ-LPDYK CDK5_Hsap YSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTK-LPDYK Cdk5_Ddis YSTPIDIWSAGCIFAEMA-SGRPLFPGSGTSDQLFRIFKILGTPNEESWPSITE-LPEYK PHO85_Scer YSTSIDIWSCGCILAEMI-TGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTK-LPKYN 9119_Tthe YSTSIDIWSIGCIFAEMV-NLKPLFPGNSETDELKRIFKLTGTPCVEKWPGLAD-LPNWK CDK5_Spur YTTSIDMWSAGCIFAEMANAGRPLFPGNDVEDQLKRIFKLLGTPTEDTWPGISK-LPDFK CC1G_03767_Ccin YSTSIDVWSCGCIFAEMI-SGVPLFRGRDNQDQLLHIMRIIGTPSPAQFAKICKETPEIQ AqueK097_Aque YNTSIDMWSAGTIFAELANAGRPLFPGSDVDEQLKRIFKLVGTPTERSWPGLTK-LPEFK GK023_Glam YGGALDIWSCGCIFYECV-TGKPLFPAKTEKDELIKIFKTLGTPDKQSWPDVDT-LPQWQ * .:*:** * *: * *** . ::* *: *:* :. : .. Cdk5_Dmel ----ALPSFPAITSWSQLVP-----RLNSKGRDLLQKLLICRPNQRISAEAAMQHPYF CDK5_Mmus ----PYPMYPATTSLVNVVP-----KLNATGRDLLQNLLKCNPVQRISAEEALQHPYF cdk-5_Cele VLHVPYPIYHPTLTWSQIVP-----NLNSRGRDLLQKLLVCNPAGRIDADAALRHAYF CDK5_Hsap ----PYPMYPATTSLVNVVP-----KLNATGRDLLQNLLKCNPVQRISAEEALQHPYF Cdk5_Ddis T---DFPVHPA-HQLSSIVH-----GLDEKGLNLLSKMLQYDPNQRITAAAALKHPYF PHO85_Scer P---NIQQRPP-RDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWF 9119_Tthe A--DAFEKYPG-EPLQNICP-----KLDELGLDLLGKMLRCNPQERITAKAGLEHPYF CDK5_Spur ----PYPIYPVTTPLASVVP-----SLSATGRDLLQRLMMCNPALRMSAEEGLMHQYF CC1G_03767_Ccin P--KQFPNYPR-LPFHQVLP-----KASPQALDLLDKLLKFDPAERISAADALAHPYF AqueK097_Aque ----EFPPYPP-ACIESVVP-----ALNDAGVDLLQRHLICHPTERISAEEAMRHEYF GK023_Glam K---DFPVYPG-INVAELLP-----TLDEAGRDLFSKMMALDPSKRPSARDCLKHPYF .: . ::: : * * * : * :*