CLUSTAL W (1.83) multiple sequence alignment grp_Dmel WTLAQTLGEGAYGEVKLLINRQ-TGEAVAMKMVDLK-KHP-D-AANSVRKEVCIQKML-- CHK1_Mmus WDLVQTLGEGAYGEVQLAVNRI-TEEAVAVKIVDMK-RAI-D-CPENIKKEICINKML-- R02C2.2_Cele YEVLKPLGQGSFGQVALVSNRRYPEMLAALKRIVITGQDR-E-YIDAIRKEITIQESLT- R02C2.1_Cele YEFIENLGEGSFAEVVLVAKVGTPNKMFAMKEISIVGKDE-C-FMESIKRECSIQKRLSK R02C2.1~b_Cele YKVVEHLCKGSFGQVHLCELTRNPSVKVAVKEVAVSGKSR-K-NLTAVQKEYKIHRRLSK chk-1_Cele YRVVQTLGEGAFGEVLLIVNTKNPEVAAAMKKINIANKSK-D-FIDNIRKEYLLQKRVSA CHK1_Scer VVLGDTVGQGAFACVKNAHLQMDPSIILAVKFIHVPTCKKMGLSDKDITKEVVLQSKCS- CHK1_Hsap WDLVQTLGEGAYGEVQLAVNRV-TEEAVAVKIVDMK-RAV-D-CPENIKKEICINKML-- Y43D4A.6_Cele FKPIKSIGKGAFGQVFLAEKLNNPRIKVAMKKINIFGAPK-E-FLEQIQQEYYIQKNM-- Chk1_Spur VELCNVLSSCQ--LVKLAVNRS-TQEAVAVKILHLD-KQQ-G-AADSVRKEVCIHRML-- DC2.7b_Cele YNVVRFLSEGTYGQVSLYESSKNPDVKIAVKQISTAGQSE-R-FVEHIKTEFAIHKGLSK R02C2.6_Cele YKVVEHLCKGSFGQVHLCELTRNPSVKVAVKEVAVSGKSR-K-NLTAVQKEYKIHRRLSK kin-33b_Cele YQVLGLLGKGTFGKVLLIELESLPGEAVAMKEIEASGEHV-EQITLNVKKEYILTKRLSA CC1G_02812_Ccin YTLVDRIGGGGFSSVYKAIDFKNY-RAAACKVIIITEET-TDKERKTLDKEMRIHSAL-- AqueK059_Aque WEFMQTLGEGAYGEVKLAVHKE-SKECVAVKIMHLDGDNA-L-TLDCLKKEICIMKML-- : * * * : : * : grp_Dmel --QDKHILRFFGKR--------SQGSVEYIFLEYAAGGELFDRIGEEPDVGMPQHEAQRY CHK1_Mmus --SHENVVKFYGHR--------REGHIQYLFLEYCSGGELFDRIE--PDIGMPEQDAQRF R02C2.2_Cele --GHENVIQVLGKE--------SDAQFCYMFLEYADGGDLYEKIT--SGCSFSLEEAHSY R02C2.1_Cele S-RHLNMIHLFEIR--------TNPENYQLILSYADGGDLFEKIN--QHGGLGSDEAHRY R02C2.1~b_Cele I-GHENVIQMMKMI--------ETPKFYSLVMEYADGGDLFDELK--EQEKFSRKDAHSY chk-1_Cele V-GHDNVIRMIGMR--------NDPQFYYLFLEYADGGELFDKIE--PDCGMSPVFAQFY CHK1_Scer --KHPNVLRLIDCN--------VSKEYMWIILEMADGGDLFDKIE--PDVGVDSDVAQFY CHK1_Hsap --NHENVVKFYGHR--------REGNIQYLFLEYCSGGELFDRIE--PDIGMPEPDAQRF Y43D4A.6_Cele --KHKNIVKMYGMS--------MDTEFCYLFQEFVTGGDLFEKID--FENGMPVNQVKGY Chk1_Spur --GDPHIIRFYGHR--------KEGSIQYLFVEYASGGELFDRIE--PDVGMQVTEAHRF DC2.7b_Cele IGGHRNVISMMEMR--------KGSDCYTLLKEYADGGDLFKKLE--TEGEQYSENAQCF R02C2.6_Cele I-GHENVIQMMKMI--------ETPKFYSLVMEYADGGDLFDELK--EQEKFSRKDAHSY kin-33b_Cele P-GHENVIRFLSIR--------TMPEHYFLIMEYADGGDLFDKIS--SEYRLTSSQAHGY CC1G_02812_Ccin --KHENVLEFLNAVVVELKHKHAYHPGYYMLMELACGGDLFDKIA--PDKGVSDDLAHLY AqueK059_Aque --RHDNVVRFFGER--------ACGKIHYLFLEYVDGGELFDRIE--PDHGMEPGLAQHF . ::: . :. . **:*:..: .: : grp_Dmel FTQLLSGLNYLHQ-RGIAHRDLKPENLLLDE------HDNVKISDFGMATMFRCK--GKE CHK1_Mmus FHQLMAGVVYLHG-IGITHRDIKPENLLLDE------RDNLKISDFGLATVFRHN--NRE R02C2.2_Cele FKQLVNGLKFLHC-RDVAHRDIKPENLMLTHSGK-SEMRHLKIADFGLATWYRYK--GAE R02C2.1_Cele FKQLIDGLRFIHE-EGVTHRDIKPENLLLTKS------GILKIADFGFATMHRFN--GAE R02C2.1~b_Cele FKQLIKGLKFIHE-QGIVHRDIKLENLLLVYSESEDDPGTLKITDFGLATKYRKD--GEE chk-1_Cele FKQLICGLKFIHD-NDVVHRDIKPENLLLTG------THVLKISDFGMATLYRNK--GEE CHK1_Scer FQQLVSAINYLHVECGVAHRDIKPENILLDK------NGNLKLADFGLASQFRRK-DGTL CHK1_Hsap FHQLMAGVVYLHG-IGITHRDIKPENLLLDE------RDNLKISDFGLATVFRYN--NRE Y43D4A.6_Cele LKQLMSGLKYIHG-CGIVHRDIKPDNLLINS------SDALKIADFGLSTRFIVD--DKE Chk1_Spur FSQLIGGVEYLHK-KGVTHRDLKPENLLLDE------HDNLKVSDFGLATVFRHQ--GKE DC2.7b_Cele FKQLISGLKFIHE-HEIVHRDIKLENLLLMKSKSNLVPDTLKIADFGLATEYMVD--GEE R02C2.6_Cele FKQLIKGLKFIHE-QGIVHRDIKLENLLLVYSESEDDPGTLKITDFGLATKYRKD--GEE kin-33b_Cele FKQLIAGLRYIHS-KGVTHRDIKPENLMLTKA-----GGVLKITDFGLGTLHIIK--GEE CC1G_02812_Ccin FNQLIAGMDYIHQ-QGVCHRDLKPENLLLDV------AGTLKISDFGLSSVYKLKDSGRT AqueK059_Aque FLQLLQGLEYLHS-RGVAHRDIKPENILLDG------YDVLKISDFGLSTVFRHL--GRE : **: .: ::* : ***:* :*::: :*::***:.: . . grp_Dmel RLLDKRCGTLPYVAPEVL----Q-KAYHAQPADLWSCGVILVTMLAGELPWDQPST-NCT CHK1_Mmus RLLNKMCGTLPYVAPELL----KRKEFHAEPVDVWSCGIVLTAMLAGELPWDQPSD-SCQ R02C2.2_Cele LIFEQRCGSVEYVAPEIY----TGAQYRGPQIDIWSAGVVLLAMLTRQLPWEFPCM-TNK R02C2.1_Cele QMLNAYCGSPPYIAPEVL----TGIDYRGPAVDIWSAGVVLIAMIAGAVPWEQADH-FDI R02C2.1~b_Cele IMLSEDCGSKPYAAPEVC----TGNDYRGPPVDIWSAGVVLMTMLVGEHSWKVANK---- chk-1_Cele RLLDLSCGTIPYAAPELC----AGKKYRGPPVDVWSSGIVLIAMLTGELPWDRASD-ASQ CHK1_Scer RVSMDQRGSPPYMAPEVL---YSEEGYYADRTDIWSIGILLFVLLTGQTPWELPSL-ENE CHK1_Hsap RLLNKMCGTLPYVAPELL----KRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSD-SCQ Y43D4A.6_Cele ILLHERIGTTPFMAPELF----AKKKHRGPPVDIWSAGILVFSLLTGNLPWDEPKE-SDI Chk1_Spur RLLGKCCGTPPYVAPEVL----KRKEYHAEPADVWSCGIILVAMLAGELPWDEPTY-SCK DC2.7b_Cele LMLVDNCGSPPYAAPEVY----SKQGHRGPPTDVWSSGVILMAMLTAGLPWDCAHR-KDV R02C2.6_Cele IMLSEDCGSKPYAAPEVC----TGNDYRGPPVDIWSAGVVLMTMLVGEHSWKVANKEKDA kin-33b_Cele SLMDTRCGTPQYAAPEVL----VGNQYRGPPVDIWSAGVVLINMLTGHSPWKKASD---A CC1G_02812_Ccin RSLTERCGSLPYVAPEVGGPLNSNAPYEAEPIDVWGCGVILFTLLVGNTPWDEPTR-HSP AqueK059_Aque RKLTRCCGTPPYIAPEVY----SGAEYYAEPADLWSCGIVLVALLSGELPWDSPSY-ECP *: : ***: . . *:*. *::: :: .*. . grp_Dmel EFTNWRD-NDHWQLQTPWSKLDTLAISLLRKLLATSPGTRLTLEKTLDHK---------W CHK1_Mmus EYSDWKE-KK-TY-LNPWKKIDSAPLALLHKILVETPSARITIPDIKKDR---------W R02C2.2_Cele RYFFWMK-NRVA-HIDAWNELSCRAKKLLWKMLSPGSENRATIEEIQSSACNRLLLGSIL R02C2.1_Cele FQSRYCSFRRNG-RKGAWSRMSQQVISLLRKILLQ-AELRATISMIEEDP---------W R02C2.1~b_Cele ------------------------------------------------------------ chk-1_Cele SYMGWIS-NTSL-DERPWKKIDVRALCMLRKIVTDKTDKRATIEQIQADP---------W CHK1_Scer DFVFFIE-NDGNLNWGPWSKIEFTHLNLLRKILQPDPNKRVTLKALKLHP---------W CHK1_Hsap EYSDWKE-KK-TY-LNPWKKIDSAPLALLHKILVENPSARITIPDIKKDR---------W Y43D4A.6_Cele LYSQWMN-NKTS-KNCIWYGLSTPVVRFLKKLLKENVNERATIEEIESDP---------W Chk1_Spur EYCDWLD-KK-MH-LSPWKKIDTTPLALLRKILTETPAKRITISQIKKDR---------W DC2.7b_Cele DYAAWID-KKFR-TDNLWNDISDRALALLRKILCVNVSERVSIEQIEADP---------W R02C2.6_Cele AYSNWIN-AKDE-KANLWNVISGPTTALLRKLLHANPEKRATMAKIEADP---------W kin-33b_Cele SYTRWFN-DECT-ERDAWSDLGARVITLLCSILAHNPTHRAPIELIEQDH---------W CC1G_02812_Ccin EFCRYLD-GTI-FDEDPWNRISETPLSLLQGMLNVNPAERMTLSDVYQHP---------W AqueK059_Aque EYREWCS-QN-CF-FTPWSKISN------------------------------------- grp_Dmel C CHK1_Mmus Y R02C2.2_Cele L R02C2.1_Cele F R02C2.1~b_Cele E chk-1_Cele Y CHK1_Scer V CHK1_Hsap Y Y43D4A.6_Cele L Chk1_Spur Y DC2.7b_Cele F R02C2.6_Cele F kin-33b_Cele F CC1G_02812_Ccin C AqueK059_Aque E