CLUSTAL W (1.83) multiple sequence alignment CG7597_Dmel FEMIAQIGEGTYGQVYKARDHHTNDMVALKKV--RLEHE------------KEGFPITAV CRK7_Mmus FDIIGIIGEGTYGQVYKAKDKDTGELVALKKV--RLDNE------------KEGFPITAI CHED_Mmus FDIIGIIGEGTYGQVYKARDKDTGEMVALKKV--RLDNE------------KEGFPITAI B0285.1_Cele --MLDQIGEGTYGQVYKAVNNLTGEQVALKRV--RLENE------------KEGFPITAI CTK1_Scer YLRIMQVGEGTYGKVYKAKNTNTEKLVALKKL--RLQGE------------REGFPITSI CRK7_Hsap FDIIGIIGEGTYGQVYKAKDKDTGELVALKKV--RLDNE------------KEGFPITAI CHED_Hsap FDIIGIIGEGTYGQVYKARDKDTGEMVALKKV--RLDNE------------KEGFPITAI DDB0229428_Ddis HEKIEQIGEGTFGQVYKAKNKSNGDIVALKKV--IMDNE------------VEGFPITAI DDB0229428_C2d_Ddis HEKIEQIGEGTFGQVYKAKNKSNGDIVALKKV--IMDNE------------VEGFPITAI 11773_Tthe YRLIAEVGSGTYGRVYKAECLRTKQYVALKKF--ESKDDK---------IKEDGFPITAV CRK7_Spur FEIINQIGEGTYGQVYKARDKDTGELVALKKV--RTDNE------------KEGFPITAV CC1G_14638_Ccin YVILNQVGEGTFGKVYKARNTVAKVHVALKRI--RMETE------------RDGFPVTAM AqueK102_Aque FEILSQIGEGTFGKVYKAKDLKTGEVIALKKVLIRTDSE------------REGFPITAV CRK7_c_Smoe ------------------------------------------------------------ CRK7a_Smoe FEKLDKIGQGTYSNVYKARDLDSGKVVALKKV--RFDSL-----------EPESVK-FMA CRK7_e_Smoe YVAVESIGRGKYGKVFLATDKQTSERVAIKRL--RVDPKEATLKVREAGGELRDVPASIA CRK7_b_Smoe ------------------------------------------------------------ CRK7_d_Smoe YVAVESIGRGKYGKVFLATDKQTSERVAIKRL--RVDPKEATLKVREAGGELRDVPASIA CG7597_Dmel REIKILRQLNHRNIVNLHEIVTDKQDAVEFRKDK-GSFYLVFEYMDHDLMGLLESG-MVD CRK7_Mmus REIKILRQLVHQSVVNMKEIVTDKQDALDFKKDK-GAFYLVFEYMDHDLMGLLESG-LVH CHED_Mmus REIKILRQLTHQSIINMKEIVTDKEDALDFKKDK-GAFYLVFEYMDHDLMGLLESG-LVH B0285.1_Cele REIKILRQLHHKNIVRLMDIVIDDISMDELKRTR-ANFYLVFEYVDHDLIGLLESKELVD CTK1_Scer REIKLLQSFDHPNVSTIKEIMVESQ----------KTVYMIFEYADNDLSGLLLNK-EVQ CRK7_Hsap REIKILRQLIHRSVVNMKEIVTDKQDALDFKKDK-GAFYLVFEYMDHDLMGLLESG-LVH CHED_Hsap REIKILRQLTHQSIINMKEIVTDKEDALDFKKDK-GAFYLVFEYMDHDLMGLLESG-LVH DDB0229428_Ddis REIKILKELNHANVVNLKEVVTSKASASN--NHK-GSVYMVFEYMDHDLNGLMDSPAFKY DDB0229428_C2d_Ddis REIKILKELNHANVVNLKEVVTSKASASN--NHK-GSVYMVFEYMDHDLNGLMDSPAFKY 11773_Tthe REILLLKQLDHVNIIKLREIILSKPSEKN--DYR-GSTFLVFDYMDHDFAGLHRN-KH-E CRK7_Spur REIKILRQLNHDSVIRLHEIVTDKQDALDFKKDK-GAFYLVFEYMDHDLMGLLESG-LVN CC1G_14638_Ccin REIKLLQSLKHPNVVQLYEMMVSN-----------GSVFMVFEYMDHDLTGILSQT-QFK AqueK102_Aque REIKILRQLRHENIVTLKEIISDTPQAASLKHDKSSSFYLVFEYCAHDLMGLIDSG-MVV CRK7_c_Smoe ------------------------------------------------------------ CRK7a_Smoe REIQILRRLDHPNVVKLEGLVTSRMS---------SSLYLVFEYMEHDLAGLAACP-GIM CRK7_e_Smoe IEIKVLRLLNNDHVVKLLDVIYAAT-----------DIFLVFEYMKHDLCGLIHRH---K CRK7_b_Smoe REIQVLRRLNHPNVIKLEGLVTSRMS---------FSLYLVFEYMEHDLAGLAACP-GIT CRK7_d_Smoe IEIKVLRLLNNDHVVKLLDVIYAAT-----------DIFLVFEYMKHDLCGLIHRH---K CG7597_Dmel FNEENNASIMKQLLDGLNYCHKKNFLHRDIKCSNILMNNRGKVKLADFGLARLYNADDRE CRK7_Mmus FSEDHIKSFMKQLMEGLDYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSE-ES CHED_Mmus FNENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSE-ES B0285.1_Cele FNKDQICSLFKQLLEGLAYIHNTGFLHRDIKCSNILVNNKGELKIADLGLARLWEK-E-S CTK1_Scer ISHSQCKHLFKQLLLGMEYLHDNKILHRDVKGSNILIDNQGNLKITDFGLARKMNSR--- CRK7_Hsap FSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSE-ES CHED_Hsap FNENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSE-ES DDB0229428_Ddis FAPGQIKCYLKQLLEGLDYCHRNNVLHRDIKGSNLLLDNNGILKLADFGLARPFNSSEKK DDB0229428_C2d_Ddis FAPGQIKCYLKQLLEGLDYCHRNNVLHRDIKGSNLLLDNNGILKLADFGLARPFNSSEKK 11773_Tthe FSLQELKCIMKQILLGVQYLHYKKVIHRDLKIANILYNNQGEVKIADFGLARLLNP-NN- CRK7_Spur FSEEHVRSFMKQLLDGLNYCHKRNFLHRDIKCSNILLNNKGHIKLADFGLARLYHADDKT CC1G_14638_Ccin FSDSHLKSLCHQMLAGLAYLHHKGVIHRDIKGSNILLNNRGELKLADFGLARFYQKR-RR AqueK102_Aque FSESHIQSLMRQLMEALCYCHSKNFLHRDLKCSNILINNKGQLKLGDWGLARYYFADDHS CRK7_c_Smoe --------------------HTRGVLHRDIKGSNLLIDNSGILKIADFGLATFYHPY-QN CRK7a_Smoe FTEPQVKCYLQQLIRGLDHCHTRGVLHRDIKGSNLLIDNSGILKIADFGLATFYHPY-QN CRK7_e_Smoe FSAPEIKCYLKQILEGLHYCHLNGVMHRDIKS---------------------------- CRK7_b_Smoe FTEPQVKCYMQQLIRGLDHCHTRGVLHRDIKGSNLLLDNSGILKIADFGLATFFHPD-QR CRK7_d_Smoe FSAPEIKCYLKQILEGLHYCHLNGVMHRDIKSANLLVSGKGVLKLADFGMSTPI-PE-TP * .:***:* CG7597_Dmel RPYTNKVITLWYRPPELLLGEERYG----------------------------------- CRK7_Mmus RPYTNKVITLWYRPPELLLGEERYT----------------------------------- CHED_Mmus RPYTNKVITLWYRPPELLLGEERYT----------------------------------- B0285.1_Cele RLYTNRVITLWYRPPELLLGDERYG----------------------------------- CTK1_Scer ADYTNRVITLWYRPPELLLGTTNYG----------------------------------- CRK7_Hsap RPYTNKVITLWYRPPELLLGEERYT----------------------------------- CHED_Hsap RPYTNKVITLWYRPPELLLGEERYT----------------------------------- DDB0229428_Ddis QILTNRVITLWYRPPELLLGTFHYG----------------------------------- DDB0229428_C2d_Ddis QILTNRVITLWYRPPELLLGTFHYG----------------------------------- 11773_Tthe PKYTNKVVTLWYRAPELLLGAKEYTEQHILKELIRNIKSIQLSLLISIYLKLTVQSSIFK CRK7_Spur RPYTNKVITLWYRPPELLLGEERYG----------------------------------- CC1G_14638_Ccin TDYTNRVITLWYRPPELLFGATVYG----------------------------------- AqueK102_Aque RLYTNHVITLWYRPPELLLGAEHYG----------------------------------- CRK7_c_Smoe LALTSRVVTLWYRPPELLLGATEYS----------------------------------- CRK7a_Smoe LALTSRVVTLWYRPPELLLGATEYS----------------------------------- CRK7_e_Smoe ------------------------------------------------------------ CRK7_b_Smoe QALTSRVVTLWYRPPELLLGATEYG----------------------------------- CRK7_d_Smoe RPLHCGVVTLWNRPPELLLGFSSYG----------------------------------- CG7597_Dmel ---PSIDVWSCGCILGELFVKRPLFQANAEMAQLETISKICGSPVPAVWPNVIKLPLFHT CRK7_Mmus ---PAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNT CHED_Mmus ---PAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVIKLPYFNT B0285.1_Cele ---PAIDVWSTGCMLGELFTRKPLFNGNNEFGQLELISKVCGSPNVDNWPELTELVGWNT CTK1_Scer ---TEVDMWGCGCLLVELFNKTAIFQGSNELEQIESIFKIMGTPTINSWPTLYDMPWFFM CRK7_Hsap ---PAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNT CHED_Hsap ---PAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVIKLPYFNT DDB0229428_Ddis ---PEIDMWSVGCIMAELLSKKTLFPGRNSIDQLDKIYQVCGSPNANNWPEAMDLPFWDA DDB0229428_C2d_Ddis ---PEIDMWSVGCIMAELLSKKTLFPGRNSIDQLDKIYQVCGSPNANNWPEAMDLPFWDA 11773_Tthe KSNKQIDMWSVGCIFIELAVGENLLRGENEPRQLDKIYELCGSPNTQNWPEVDKLQLWKD CRK7_Spur ---PAVDVWSCGCILGELFTQRPIFQANQELAQLELISRICGTPTPAVWPDVIRLPLFNT CC1G_14638_Ccin ---PEVDMWSAGCIMLELFTKKPVFQGNDEINQLHVIFKILGTPTTERWTGLNNLPWFEL AqueK102_Aque ---PAVDIWSCGCILGELFTKKPLFHGSIEMEQLDAIS---------------------- CRK7_c_Smoe ---VGVDLWSTGCILAELLAGKPIMPGRT------------------------------- CRK7a_Smoe ---VGVDLWSTGCILAELLAGKPIMPGRTEVEQLHKIFKLCGSPSEEYWKK-SKLPHATI CRK7_e_Smoe ------------------------------------------------------------ CRK7_b_Smoe ---AAVDLWSTGCILAELLAGKPIMPGRTEVEQLHKIFKLCGSPAEEYWKK-WKLPHAII CRK7_d_Smoe ---PAVDMWSLGCVFAELLVCQSILPGKDEKQQLSWIFKMCGTPDETSWPGVSKSPVYAK CG7597_Dmel LKQKKT--HRRRLREDF------EF-MPA-PALDLLDKMLDLDPDKRITAEDALRSPWL CRK7_Mmus MKPKKQ--YRRRLREEF------SF-IPS-AALDLLDHMLTLDPSKRCTAEQTLQSDFL CHED_Mmus MKPKKQ--YRRKLREEF------VF-IPA-AALDLFDYMLALDPSKRCTAEQALQCEFL B0285.1_Cele FRMKRT--YQRRIREEF------EHIMPR-EAVDLLDKMLTLNPEKRISAKEALNHPWI CTK1_Scer IMPQQTTKYVNNFSEKF------KSVLPSSKCLQLAINLLCYDQTKRFSATEALQSDYF CRK7_Hsap MKPKKQ--YRRRLREEF------SF-IPS-AALDLLDHMLTLDPSKRCTAEQTLQSDFL CHED_Hsap MKPKKQ--YRRKLREEF------VF-IPA-AALDLFDYMLALDPSKRCTAEQALQCEFL DDB0229428_Ddis LKPKRE--YNSLSLKDFYQHENPSF-FTK-EAFDLLDKLLCMDPKKRITASEALDHQYF DDB0229428_C2d_Ddis LKPKRE--YNSLSLKDFYQHENPSF-FTK-EAFDLLDKLLCMDPKKRITASEALDHQYF 11773_Tthe MKPKRN--FERKLREQV-I-ERKKN-IDP-QFLNLLDGIMVLNPKKRFTVQQCLDHEFF CRK7_Spur MKPKKM--YNRRLREEF------SL-LPK-DALDLLDGMLTLDPDKRTTAEDALNCGWL CC1G_14638_Ccin IKPKES--LPNRFRDLF------QKWMSP-AALDLAERLLTYDPELRVSAQEAMEAPYF AqueK102_Aque ------------------------I-IPE-VPLDLLDKLISIDPSKRISSEEALNHPFL CRK7_c_Smoe ----------------------------------------------------------E CRK7a_Smoe FKPQQP--YKRCIADTY------KD-FPS-TALALLDILLAIEPADRGTAAGALKADFF CRK7_e_Smoe ----------------------------------------------------------S CRK7_b_Smoe FKPQQP--YKRCIAETF------KD-FPA-SALALLDTLLAIEPADRQTAAAALESDFF CRK7_d_Smoe FVAENGK-KPRRLRKAF------NN-VDP-RALDLLEQMLTLNPEKRITAEQALLSDYL