CLUSTAL W (1.83) multiple sequence alignment GCN2_Hsap -FEELQLLGKG-AFGA-VIKV-Q---------------------NKLD-GCCYAVK--RI GCN2~b_Hsap -VHKGKCIGSDEQLGK-LVYN-ALETATGGFVLLYEWVLQW--QKKMG-PFLTSQE--KE Gcn2_Dmel -IQRGCCVGHS-QRGC-IAYT-G---------------------IDMHCGQLLYIT--EW Gcn2~b_Dmel -FEVLMYLGKG-AFGD-VLKV-R---------------------NILD-NREYAIK--RI GCN2_Mmus -FEELQLLGKG-AFGA-VIKV-Q---------------------NKLD-GCCYAVK--RI GCN2~b_Mmus -VHKGRCVGSDEQLGK-VVYN-ALETATGSFVLLHEWVLQW---QKMG-PCLTSQE--KE GCN2_Scer -FEEIAVLGQG-AFGQ-VVKA-R---------------------NALD-SRYYAIK--KI Y81G3A.3_Cele -NVIIRVLGRG-GFGD-VVLV-R---------------------NKMD-STDYAIK--RI DDB0216407_Ddis -FEEIQLLGRG-GFGQ-VVKV-R---------------------NKLD-GRYYAIK--KI IfkB_Ddis -EQSSSDSENG-ENGM-KSRIIE---------------------NASD-S---------- 11434_Tthe -FRVIDELGRG-GFGR-VYKV-Q---------------------SMVE-EKIYAIK--KI 18670_Tthe -FEEVEQIGKG-GFGQ-VYKV-K---------------------NRLD-SLNYAVK--KI 21870_Tthe -FEEIQVLGQG-AFGQ-VVKV-R---------------------NKLD-GRYYAIK--KI GCN2_Spur -FEFLAFLGKG-GFGN-VIKV-R---------------------NKLD-GNLYAIK--KI GCN2~b_Spur -VHKGILLGSN-PEGS-SVYA-GMDAHSGDLLTIREWVIKWKQG--KG-RKPLPDE--EE CC1G_02807_Ccin -WEELELLGKG-AFGS-VVKA-R---------------------NKVD-NRVYAVK--KV AqueK195_Aque -FEVLEVLGKG-GFGD-VIKV-R---------------------NYLD-SRLYAIK--KV AqueK195~b_Aque NILRGKLLGDS-SHGYYSVYC-GMEVDSGSLVCIYEWIIPCKTQKKAD-TRRSRQAGGAG AqueK194_Aque -FEVLEVLGKG-GFGD-VIKV-R---------------------NYLD-SRLYAIK--KV AqueK194~b_Aque NILRGKLLGDS-SHGYYSVYC-GMEVDTGSLVCVYEWIIPCKTQKKAD-TRRSRQA-GAG AqueK193_Aque -FEEIKLLGKG-AFGE-VYHV-K---------------------HNLD-KKEYAMK--II PEKc_Smoe -FEELCLLGKG-GFGH-VVLC-K---------------------NKLD-GRRYAMK--KV PEKa_Smoe -FEELCLLGKG-GFGH-VVLC-K---------------------NKLD-GRRYAMK--KV GK065_Glam -FVELYQLGKG-GYGE-VVCA-N---------------------RLME-NQKYAVK--KV . * GCN2_Hsap PIN-------------------------PA--SR------------QFRRIKGEVTLLSR GCN2~b_Hsap KID-------------------------KC--------------KKQIQGTETEFNSLVK Gcn2_Dmel NIKYSQLEQPCIGGGKCHWSSESKCMGSHR--V-----------DEVMASIEKQVSSLSQ Gcn2~b_Dmel PLP-------------------------AR--SR-----------QLYKKMTREVELLSR GCN2_Mmus PIN-------------------------PA--SR------------HFRRIKGEVTLLSR GCN2~b_Mmus KID-------------------------KC--------------KRQIQGAETEFSSLVK GCN2_Scer RHT-----------------------------EE------------KLSTILSEVMLLAS Y81G3A.3_Cele PLN-------------------------AK--SD-----------KLNRKIAKEAKFFAK DDB0216407_Ddis KLD-------------------------SN--QS------------LNRRILREVITLSR IfkB_Ddis ------------------------------------------------------------ 11434_Tthe AVP-------------------------YDGFSN-----------PKEHKYFREVKSIMS 18670_Tthe KLD-------------------------IN--QK-----------ELTKKTLKEVKLLSI 21870_Tthe KIR-------------------------KG---------------QNIEKLMREVTLLSR GCN2_Spur LLN-------------------------PK--SR-----------ELNKKITREVKLLSR GCN2~b_Spur DAE-------------------------AC--------------LKQCASVEQELLSLLR CC1G_02807_Ccin RLK-------------------------AV--Q-------------KDDKIMREVNALSR AqueK195_Aque RLT-------------------------GG--SK------------MMTKLTREVELLSQ AqueK195~b_Aque SVG-------------------------RS--E-----------GNLVASIRQEYDSFSE AqueK194_Aque RLT-------------------------GG--SK------------MMTKLTREVELLSQ AqueK194~b_Aque SVG-------------------------RS--E-----------GNLVASIRQEYDSFSE AqueK193_Aque PAN------------------------------------------KINQKDLREVLALSD PEKc_Smoe KLK-------------------------DE---------------NPSDKILREVATLSR PEKa_Smoe KLK-------------------------DE---------------NPSDKILREVATLSR GK065_Glam VID-------------------------RR--DFHAKTESVGGFLQYIKSIMNEVRILSR GCN2_Hsap --LHHENIVRYYNAWIERHERPAGPGTP------------------PPD--------SG- GCN2~b_Hsap --LSHPNVVRYLAMNLKEQ----------------------------------------- Gcn2_Dmel --LQHKNLVSYECVLCIKRK---------------------------------------- Gcn2~b_Dmel --LNHENVVRYFNSWIESV----------------------------------------- GCN2_Mmus --LHHENIVRYYNAWIERHERPAVPGTP------------------PPD--------CT- GCN2~b_Mmus --LSHPNIVRYFAMNSREE----------------------------------------- GCN2_Scer --LNHQYVVRYYAAWLEED----------------------------------------- Y81G3A.3_Cele --LNHPNMVRYYYAWAEDLIPIVEETSD------------------DDSSLGAVPIPGKE DDB0216407_Ddis --LHHQHVVRYYQAWIESAESLSLTNDNSDDDDDDDDEFESGSESEESQ--------SE- IfkB_Ddis ----------Y-------------SDDDNNNNNDSNNNYHSDNE---SD--------SF- 11434_Tthe --LNHINIVRYHTSWWENCDDEMVNQVN------------------EFL--------QT- 18670_Tthe --LQHNHIVRYYQAWLEKPDEKTLQEFE------------------NSE--------EE- 21870_Tthe --LHHRHVLRYYQAWLEESNQSEEE---------------------E-S--------MG- GCN2_Spur --LNHENVVRYYNSWIEVAEEPPTTDTD------------------ESR--------TT- GCN2~b_Spur --LEHANIVHYLAMNYNKG----------------------------------------- CC1G_02807_Ccin --LNHRFIVRYYTTWIETTEAPSTTVSD------------------DSS--------AE- AqueK195_Aque --MNHENIVRYYNAWIEKYSEPNHHGNE------------------EEG--------EE- AqueK195~b_Aque RFINHSSIVKYLLMRHNLT----------------------------------------- AqueK194_Aque --MNHENIVRYYNAWIEKYSEPNHHGNE------------------EEG--------EE- AqueK194~b_Aque RFISHSSIVKYLLMRHNLT----------------------------------------- AqueK193_Aque --FKHSGIVQYYCSFID------------------------------------------- PEKc_Smoe --LQHQHVVRYYQAWFETAAGGSS-GTP------------------Y-G--------EE- PEKa_Smoe --LQHQHVVRYYQAWFETAAGGSS-GTP------------------Y-G--------EE- GK065_Glam --LLHPFIVKYYYSWIETTSDTVQNATE------------------A-P--------NS- * GCN2_Hsap ------------------------------------------------------------ GCN2~b_Hsap ------------------------------------------------------------ Gcn2_Dmel ------------------------------------------------------------ Gcn2~b_Dmel ------------------------------------------------------------ GCN2_Mmus ------------------------------------------------------------ GCN2~b_Mmus ------------------------------------------------------------ GCN2_Scer ------------------------------------------------------------ Y81G3A.3_Cele KIGKKGKLKTGKSLEDKENKANLGGGDSLMPMNLRGLVKDHSIGVDAKEWSTPFGKPEGP DDB0216407_Ddis ------------------------------------------------------------ IfkB_Ddis ------------------------------------------------------------ 11434_Tthe ------------------------------------------------------------ 18670_Tthe ------------------------------------------------------------ 21870_Tthe ------------------------------------------------------------ GCN2_Spur ------------------------------------------------------------ GCN2~b_Spur ------------------------------------------------------------ CC1G_02807_Ccin ------------------------------------------------------------ AqueK195_Aque ------------------------------------------------------------ AqueK195~b_Aque ------------------------------------------------------------ AqueK194_Aque ------------------------------------------------------------ AqueK194~b_Aque ------------------------------------------------------------ AqueK193_Aque ------------------------------------------------------------ PEKc_Smoe ------------------------------------------------------------ PEKa_Smoe ------------------------------------------------------------ GK065_Glam ------------------------------------------------------------ GCN2_Hsap ---------------------PLAKDDR-AARGQPASD-TDG-----------LDSVEAA GCN2~b_Hsap ------------------------------------------------------------ Gcn2_Dmel ------------------------------------------------------------ Gcn2~b_Dmel ------------------------------------------------------------ GCN2_Mmus ---------------------PQAQDSP-ATCGKTSGD-TEE-----------LGSVEAA GCN2~b_Mmus ------------------------------------------------------------ GCN2_Scer ------------------------------------------------------------ Y81G3A.3_Cele KCASRMRQSKRSTPSGGLKHLSECSSDDEDDDDS-------------------------- DDB0216407_Ddis ---------------------SESESSE------S-EESS--------------ESEE-- IfkB_Ddis ---------------------SGSISMS-DGNGSG-YEAT--------------DDEDI- 11434_Tthe ---------------------NNNLYSD-D-NSPSVSEA-YQ--------------KNKS 18670_Tthe ---------------------DELREDSKEEECS-------------------------- 21870_Tthe ---------------------SQ-MSDQ-DDDNG-------------------------- GCN2_Spur ---------------------GTGETSP-DTNGVG-RG-A-REVPLAVNSLSLSDNIEEQ GCN2~b_Spur ------------------------------------------------------------ CC1G_02807_Ccin ---------------------SSMITSS-EVTSI--PD-DD------------------- AqueK195_Aque ---------------------FS-DSSE-DEDTTE-EE-E--------------EEEEER AqueK195~b_Aque ------------------------------------------------------------ AqueK194_Aque ---------------------FS-DSSE-DEDTTE-EE-E---------------EEEER AqueK194~b_Aque ------------------------------------------------------------ AqueK193_Aque ------------------------------------------------------------ PEKc_Smoe ---------------------SE-ISSS-WVDTP-------------------------- PEKa_Smoe ---------------------SE-ISSS-WVDTA-------------------------- GK065_Glam ----------------------SMISSG-CTTGT-------------------------- GCN2_Hsap APPPILSSSVE-WSTSGERSASARFPATGPGSSDDEDDDE-DEHG-----------GVF- GCN2~b_Hsap ------------------------------------------------------------ Gcn2_Dmel ------------------------------------------------------------ Gcn2~b_Dmel ------------------------------------------------------------ GCN2_Mmus APPPILSSSVE-WSTSAERSTSTRFPVTGQDSSSDEE-DE-DERD-----------GVF- GCN2~b_Mmus ------------------------------------------------------------ GCN2_Scer ------------------------------------------------------------ Y81G3A.3_Cele -------SEID-WDAESEEVE---------DEESDDSDEE-DEDDGERLVQLNTETSTG- DDB0216407_Ddis --------SSES-SES-EESEE--------SEYSDDSEFE-SEENNDFD-------QSF- IfkB_Ddis -----IN-NSGSFDDN-ENDDD--------DEEDDDDEYD-E-EDDDYE--------TF- 11434_Tthe D----YNR--S-YALSKQTNQT-------------------------------------- 18670_Tthe -------S-------------------------ENDSAPSKASKESSMCF--EFIESSEE 21870_Tthe -----------------E----------------LSDDRY-RYRS-----------NNF- GCN2_Spur ALKLSIRNSLE-WSSSGNIG-----------LIGDSDDSS-SDDE-----------GVF- GCN2~b_Spur ------------------------------------------------------------ CC1G_02807_Ccin --------------------SERHLPINGGFDLGDLD-DL-DDEL-----------G--- AqueK195_Aque EEGLS---FIE-FKLDE--S-----------TTLNSSDQI-RDDS-----------YSF- AqueK195~b_Aque ------------------------------------------------------------ AqueK194_Aque EEGLS---FIE-FKLDE--S-----------TRLDSSDQI-RDDS-----------YSF- AqueK194~b_Aque ------------------------------------------------------------ AqueK193_Aque ------------------------------------------------------------ PEKc_Smoe ------------------------------------------------------------ PEKa_Smoe ------------------------------------------------------------ GK065_Glam ---------------------------------GDDS------LEGSLGA----VTRAL- GCN2_Hsap -SQSFLPASDSES----DIIFDNED----------------------------------- GCN2~b_Hsap ------------------------------------------------------------ Gcn2_Dmel ------------------------------------------------------------ Gcn2~b_Dmel ------------------------------------------------------------ GCN2_Mmus -SQSFLPASDSDS----DIIFDNED----------------------------------- GCN2~b_Mmus ------------------------------------------------------------ GCN2_Scer ------------------------------------------------------------ Y81G3A.3_Cele -ADSVFERSTADE----DVVFTAESE----------------DLNAK------------- DDB0216407_Ddis -SEVFLFQNGNKR----SLEFDLTDDSYSFLHSDCGFLLEVFDLNNKIGGNNTRSMGSSN IfkB_Ddis ---------------------DF------------------------------------- 11434_Tthe --QSYVLSYNNDN--LSCIEWEQSEN---------------------------------- 18670_Tthe SSLPFEFENYSDN----GIVFEDSDG----------------DEEQK------------- 21870_Tthe -SSRYQDNNSSY--------YD-------------------------------------- GCN2_Spur -GRSFLPRSDDSS--SDGIDFEGSDR---------------------------------- GCN2~b_Spur ------------------------------------------------------------ CC1G_02807_Ccin -SQSSFPS----------IHFEGSKS---------------------------------- AqueK195_Aque -SSDVFTDTEDRDVFKGKVDTPGTNV---------------------------ATLLEAD AqueK195~b_Aque ------------------------------------------------------------ AqueK194_Aque -SSDVFTDTEDRDVFKGKVDTPGTNV---------------------------ATLLEAD AqueK194~b_Aque ------------------------------------------------------------ AqueK193_Aque ------------------------------------------------------------ PEKc_Smoe ------------------------------------------------------------ PEKa_Smoe ------------------------------------------------------------ GK065_Glam ------------------------------------------------------------ GCN2_Hsap -----------------------E--------NSKS--QNQDEDCNEK------------ GCN2~b_Hsap ------------------------------------------------------------ Gcn2_Dmel ------------------------------------------------------------ Gcn2~b_Dmel ------------------------------------------------------------ GCN2_Mmus -----------------------E--------NSKS--QNQDEDCNQK------------ GCN2~b_Mmus ------------------------------------------------------------ GCN2_Scer ------------------------------------------------------------ Y81G3A.3_Cele -----------RR-------------------ES--------IELMEIN----------- DDB0216407_Ddis QHLQQQQQQNQSQQQKKQPQ-QNQSQQQKKLKNSNSKSKSKSKSKSKSK---SK------ IfkB_Ddis ----------------------------------------QDKSRVV------S------ 11434_Tthe ------------EN--QNPNISNNDGIKKK--LDDS--QTIN-EYREQ------------ 18670_Tthe -----------QKN--QNSSTANNKQETHKRKESQI------QDIDETD----------- 21870_Tthe -----------------------L--------SSLR--NSQDSSVREQS----------- GCN2_Spur ------------G----------E--------ESDI-SLSISNRVKESKGNRG------- GCN2~b_Spur ------------------------------------------------------------ CC1G_02807_Ccin ------------P----------A--------NSDS--SG-DDSLFDSM----------- AqueK195_Aque LMVTTPRRGFIHS----------E--------SSDS-VVFQDTSLMAPPGGEGEEGSTAA AqueK195~b_Aque ------------------------------------------------------------ AqueK194_Aque LMVTTPRRGFIHS----------E--------SSDS-VVFQDTSLMAPPGGEGEEGSTAT AqueK194~b_Aque ------------------------------------------------------------ AqueK193_Aque ------------------------------------------------------------ PEKc_Smoe ------------------------------------------------------------ PEKa_Smoe ------------------------------------------------------------ GK065_Glam -----------------DSPS--------------------------ST----------- GCN2_Hsap -------N-GCHE--SEPSVTTEAVHYLYIQMEYCEKSTLRDTIDQGL------------ GCN2~b_Hsap ----------------------DDSIVVDILVEHISGVSLAAHLSHSG------------ Gcn2_Dmel -----------------------EGLLVYLVQDFLLGTSVFSISSS-L------------ Gcn2~b_Dmel --------------------------DMYIQMEFCEKCTLRTAIDDNL------------ GCN2_Mmus -------D-GSHE--IEPSVTAEAVHYLYIQMEYCEKSTLRDTIDQGL------------ GCN2~b_Mmus ----------------------EDSIVIDILAEHVSGISLATHLSHSG------------ GCN2_Scer -------------------------SMLFIQMEYCENRTLYDLIHSENL----------- Y81G3A.3_Cele ----TTTTSKSKL--AIDVVPVRKPRILCIQMEYCDRATLRQYIDENHC----------- DDB0216407_Ddis ----SNSKKSISSSKLKNIKKSTSIPYLYIQMEYCQK-ILRNLTETGM------------ IfkB_Ddis ----NNSKLSTSS---SRKKPPKETHTLYIQMEYCSKKTLKTLIDNVG------------ 11434_Tthe -------N-KSHK-TFNFTKEPSQLLTLYIQLEYCSGKTLRNYLDEQTH----------- 18670_Tthe ----FFTKEDKKK--HHKKKKSKDFRLLHIQMEFCGGSTLREMIDNHFFCAE-----KEK 21870_Tthe -------GKNQEN--QKYPVTNFKLMILFIQLEYCPS-TLSHQIKELKF----------- GCN2_Spur ----K--SKEEDI--SEDNPVFSPVQYLYIQMEFCEKSTLRTAIDAGM------------ GCN2~b_Spur ----------------------KEDINVQLLMEYVGGGNLSQKLENSSL----------- CC1G_02807_Ccin ----S--PTNKNL--T-FPSNFGPSRTLYIQMEFVERQTLRERVDEG-I----------- AqueK195_Aque AGGGG--GAGGGR---AKQKQTGQSQYLYIQMEYCSNQTLKVLIDSGQ------------ AqueK195~b_Aque ----------------------EHGILVEVTMEYITGGSLNSLLQGSSSS---------- AqueK194_Aque G---G--GGAGGR---AKQKQTGQSQYLYIQMEYCSNQTLKVLIDSGQ------------ AqueK194~b_Aque ----------------------EHGILVEVGMEYITGGSLNSLLQGSSSS---------- AqueK193_Aque ------------------------------------------------------------ PEKc_Smoe -----------GS---SSNDVNTVSTFLYIQMEYCPR-TLREVFDTRS------------ PEKa_Smoe -----------GS---SSNDVNTVSTFLYIQMEYCPR-TLREVFDTRS------------ GK065_Glam ----PFSTP-KPT--RSTERREIEKVIVFVQMEYCSHGCLSGFIQQCSDGAALCPPLAQG GCN2_Hsap YRDT---VRLWRLFREILDGLAYIHEKGMIHRDLKPVNIFLDSDDH-----VKIGDFGLA GCN2~b_Hsap PIPV---HQLRRYTAQLLSGLDYLHSNSVVHKVLSASNVLVDAEGT-----VKITDYSIS Gcn2_Dmel GWCM---DGARMVARGVLDALVFLHNKGVSHSHLLDTTVFMDNTGN-----VRVSDFSLV Gcn2~b_Dmel FNDT---DRLWRLFREIAEGLAHIHQQGIIHRDLKPVNIFLDSHDQ-----IKIGDFGLA GCN2_Mmus FRDT---SRLWRLFREILDGLAYIHEKGMIHRDLKPVNIFLDSDDH-----VKIGDFGLA GCN2~b_Mmus PVPA---HQLRKYTAQLLAGLDYLHSNSVVHKVLSASSVLVDAEGT-----VKITDYSIS GCN2_Scer NQQR---DEYWRLFRQILEALSYIHSQGIIHRDLKPMNIFIDESRN-----VKIGDFGLA Y81G3A.3_Cele FNAP---TEVWRIFSEVLCGLKYMHDMAMIHRDIKPLNIFLTSQNG-----VKIGDFGLA DDB0216407_Ddis NLED---DDIWKLFRQIVEGMAYVHGQGIIHRDLKPSNIFFDSCGD-----IKIGDFGLA IfkB_Ddis GIAE---EEAFRLLRQIVEGLNHIHSQQIIHRDLKPANIFIDNEQN-----VKIGDFGLA 11434_Tthe GLDS---KEAFQIFSQMLEGVNYLHKNQIIHRDLKPSNILFEN-KI-----AKIADFGLS 18670_Tthe RISS---KQKKSLLAQILEALKYLHEKELIHRDLKPQNILLDQSGQ-----IKLVDFGLA 21870_Tthe QQDT---VQIWQYFRQILEGLNYIHSQNTIHRDLKPENIFIDCLGD-----IKIGDFGLA GCN2_Spur YEDK---RRLWTHFREIIEGLAHIHLQGMIHRDLKPVNIFLDSNDF-----VKIGDFGLA GCN2~b_Spur -TSF---DLLREYAIDLLSGLQYLHSHAVVHKQLRASQVYVDCDGR-----LRVANYSMC CC1G_02807_Ccin --SE---EEGWRLFHQIVDALVHMANLGIIHRDIKLTNIFIALAKIMGLTLFPVGDFGLA AqueK195_Aque LVKSPGFELGWQLFREITEGLAHIHSQGMIHRDLKPVNIFLNSSGH-----CKIGDFGLA AqueK195~b_Aque PITG---KSLQLYSKQLLEAVAYLHSQGIVHNDIRPSLVFIDPVQG-----VKLAGHTII AqueK194_Aque LIKSSGFELGWQLFREITEGLAHIHSQGMIHRDLKPVNIFLNSSGH-----CKIGDFGLA AqueK194~b_Aque PITG---KSLQLYSKQLLEAVAYLHSQGIVHNDIRPSLVFIDPVQG-----VKLAGHTII AqueK193_Aque ------------------------------------------------------------ PEKc_Smoe VLDK---ELTWGIFRQIVEGLSHIHGQGIIHRDLTPSNIFFDTRND-----VKIGDFGLG PEKa_Smoe VLDK---ELTWGIFRQIVEGLSHIHGQGIIHRDLTPSNIFFDTRND-----VKIGDFGLG GK065_Glam LTLT---ELLWRMTAQLASAVAYIHSKDIVHYDIKPANVFLDESYN-----IKLGDFGTS GCN2_Hsap TDHLAFSADS---KQ---DD---QT---G------------------------------- GCN2~b_Hsap KRLADICKED---VF---E----QT----------------------------------- Gcn2_Dmel PNLLELLSGA-------------------------------------------------- Gcn2~b_Dmel TTSFLALQAH---DA---AP---A------------------------------------ GCN2_Mmus TDHLAFTAEG---KQ---DD---QA---G------------------------------- GCN2~b_Mmus KRLADICKED---VF---E----QA----------------------------------- GCN2_Scer KNVHRSLDIL---KL---DS---QN----------------------------------- Y81G3A.3_Cele TLEAMSSKGKIV-GG-AAEKS--TS-IEA-----------------------------M- DDB0216407_Ddis INNKTTSTLSPTTNI---NS---STSSAG---SLTTSSNSVQSVINTKQQQQQQQPQNYW IfkB_Ddis TSGAPVSKSD---DL---NS---STSNAA---NN----------------------INLS 11434_Tthe IQQELGLINA---NQ------E-LP-S--------------------------------- 18670_Tthe TTLKKERQIERK-AVLNLKRA--SS-VQSNFYNA------------------S----SLP 21870_Tthe KSQKQNVFSK---YQYVIEKEE-NE-LFNQLVN--------------------------- GCN2_Spur TSEQMAGALT---SE---VS-CHNR-L-T------------------------------- GCN2~b_Spur KRLNELAQAA---NE---G----KQ----------------------------------- CC1G_02807_Ccin TSSLAAVDPS---DV--------QH----------------------------------- AqueK195_Aque TTFSKYHTGL---SR---Q----QS-I--------------------------------- AqueK195~b_Aque KRLSDLTGK----VN---E----EA----------------------------------- AqueK194_Aque TTFSKYHTGL---SR---Q----QS-I--------------------------------- AqueK194~b_Aque KRLSDLTGK----VN---E----EA----------------------------------- AqueK193_Aque ------------------------------------------------------------ PEKc_Smoe VCAAKFADLQ---NP---DQ-D-HR-V--------------------------------- PEKa_Smoe VCAAKFADLQ---NP---DQ-D-HR-V--------------------------------- GK065_Glam YTCKGPSDDQD-----------------------------------------------L- GCN2_Hsap -----------------D---LIKSDPSGHLTGMVGTALYVSPEVQGS------------ GCN2~b_Hsap ------------------RVRFSD------------------------------------ Gcn2_Dmel ------------------------------------------------------------ Gcn2~b_Dmel ------------------PVNQITSAEDGTGTGKVGTTLYVAPELTGN------------ GCN2_Mmus -----------------D--GVIKSDPSGHLTGMVGTALYVSPEVQGS------------ GCN2~b_Mmus ------------------RVRFSD------------------------------------ GCN2_Scer ---------------------LPGS--SDNLTSAIGTAMYVATEVLDG------------ Y81G3A.3_Cele ----------------LSPNGVKSKGSDVHQTRDIGTQLYMAPELFVDE----------- DDB0216407_Ddis EDEVEGQQQQQQQQQQQQQQQQQQQQQQQQHTARVGTLFYTSPEQEAGT----------- IfkB_Ddis ---------SSTNSTAQQTPMWDLNDENLSMTGGVGTPFYCCPEILEKN----------- 11434_Tthe ------------------QKNIDGQDISVAHTGNVGTPFYMPPEQQDK------------ 18670_Tthe ---------GEIDYK-DKKSENSNNYFPSEITRGVGTGVYRAPEQEN------------- 21870_Tthe -----------------KQYLTEKELEAIDQTLNVGTYFYRPPAS--------------- GCN2_Spur -----------------DSSHSGEATPGNHLTGKVGTALYVAPELCKA------------ GCN2~b_Spur ------------------TVRFSDD----------------------------------- CC1G_02807_Ccin -----------------KP---VTY--DPEMTLEVGTRLYIAPEVQWTG----------- AqueK195_Aque ------------------PSN--TS-ILAGDTGLVGTMLYLAPELLKS------------ AqueK195~b_Aque ------------------WPR--------------------------------------- AqueK194_Aque ------------------PSN--TS-ILAGDTGLVGTMLYLAPELLKS------------ AqueK194~b_Aque ------------------WPR--------------------------------------- AqueK193_Aque ------------------------------------------------------------ PEKc_Smoe ------------------PVKFEANVKSLEGTGQVGTYFYRAPEIEQA------------ PEKa_Smoe ------------------PVKFEANVKSLEGTGQVGTYFYRAPEIEQA------------ GK065_Glam ------------------------------FASDRSTLSYMAPELSAQHWMQSSLNNAAQ GCN2_Hsap ---TKSAYNQKVDLFSLGI--------------------IFFEMSYHPMVTASERIFVLN GCN2~b_Hsap -NALPYKTGKKGDVWRLGL--------------------LLLSLSQG-QECG-------- Gcn2_Dmel -----GQSSSCGDLPALGA--------------------LVESLM-PT------------ Gcn2~b_Dmel --ASKSVYNQKVDMYTLGI--------------------ILFEMCQPPFDTSMERAQTIM GCN2_Mmus ---TKSAYNQKVDLFSLGI--------------------IFFEMSYHPMVTASERIFVLN GCN2~b_Mmus -SALPYKTGKKGDVWRLGL--------------------LLLSLSQG-QECG-------- GCN2_Scer ----TGHYNEKIDMYSLGI--------------------IFFEMIY-PFSTGMERVNILK Y81G3A.3_Cele -LVHKAPYTSKIDIYSAGV--------------------VLFEMFYRPLPPSMDRVSTLN DDB0216407_Ddis --NGDSAYDDKVDMYSLGI--------------------VFFEMWYV-FSTGHERVIVLR IfkB_Ddis ----TKHYGTKVDMYSLGI--------------------IFFEMCFQ-FQTQMERSNILR 11434_Tthe ----SGKYNEKIDVYSLGI--------------------ILLEIIHK-MDTYHEKLEIVK 18670_Tthe ----TSSYCTKADMFSLGILNQAKQYFNNLIFKINKIGVIIFEMWYP-LPTFMEKYQTLK 21870_Tthe ----QSMHEERADIYALGI--------------------IFFEMWFY-FQSKYQRFKVLT GCN2_Spur ---RIGHYNQKVDLYSLGI--------------------IFFEMCYRSLSTGMERVKILG GCN2~b_Spur -KTYGGRGGKKGDVLDLGL--------------------LLLGLLLG-TSDV-------- CC1G_02807_Ccin -RRAAPKNHNKADMYSLGI--------------------VFFEMNYR-FTTGSERIVVLE AqueK195_Aque ----VVKYTQKVDMYSLGI--------------------ILYEMSHPPPATVMERVKILT AqueK195~b_Aque -GFFTKLGGKKTDILKLGM--------------------VIFCMSVG-RVTV-------- AqueK194_Aque ----VVKYTQKVDMYSLGI--------------------ILYEMSHPPPATVMERVKILT AqueK194~b_Aque -GFFTKLGGKKTDILKLGM--------------------VIFCMSVG-RVTV-------- AqueK193_Aque ------------------------------------------------------------ PEKc_Smoe ----WPHIDEKVDMYSLGV--------------------ILFELWHP-FSTGMERYVTLN PEKa_Smoe ----WPHIDEKVDMYSLGV--------------------ILFELWHP-FSTGMERYVTLN GK065_Glam SNLPVTALRKQADMYSLGI--------------------TLLELWFL--PTASDNLSNLR GCN2_Hsap QLRDPTSPKFPEDFDD-GEH----AKQKSVISWLLNHDPAKRPTATELLKS------ELL GCN2~b_Hsap --------EYPVTIPS-DLP----ADFQDFLKKCVCLDDKERWSPQQLLKH------SFI Gcn2_Dmel ----------------------NSYEMRDFVD---KCNSDRTLSASELLEH------PFL Gcn2~b_Dmel ALRNV-SINIPDAMLKDPKY----EKTVKMLQWLLNHDPAQRPTAEELLIS-------DL GCN2_Mmus QLRDPTSPKFPDDFDD-GEH----TKQKSVISWLLNHDPAKRPTAMELLKS------ELL GCN2~b_Mmus --------EYPVTIPS-DLP----ADFQDFLKKCVCLDDKERWSPQQLLKH------SFI GCN2_Scer KLRSV-SIEFPPDFDD-NKM----KVEKKIIRLLIDHDPNKRPGARTLLNS------GWL Y81G3A.3_Cele NLRDD--IKIPSDFGA-GLAAPMAGLARRTVEKMLQRNPDERPTADDLLN------DEDL DDB0216407_Ddis NLREK--FEFPSDFER-NH-----SRQATLIRMLIDKDPAKRPSAQQLLQS------ELM IfkB_Ddis DLRDN--LKFPPGFES-TK-----PDQTQIIRSLLSRDPTQRPSTKQLLES------GLL 11434_Tthe KLKGS--QELPKNLQK-TQ-----KYACELIIQMTSLKPQNRPSIEQILQG-----KTYM 18670_Tthe EIREK--NQLPQDFNL-KVGN-DAKEIRDILTKLLDPDPSKRYSAEELLK--------TL 21870_Tthe ILRNN--NLFPDQFEQ-FH-----PKQAKLIAWMLNFSSQKCQKVMEIMQS------DLI GCN2_Spur QIRQE-SIQLPEDFDE-VRN----TNENAIVHWLLNHDPKERPTSQELLES------KLL GCN2~b_Spur --------QYPCEVPQ-DLP----LDLQDFLNRCIDIDERSRANVQSLLDH------PFI CC1G_02807_Ccin DLRKP-GIFFPTSWEP-HR-----TRQREIITWLLQHDPEKRPSALDLSQS------PLM AqueK195_Aque DVRKK-EIVFSERFKT-SKK----MSKQAVEHTLQNPNSSQYKRLMEKL--------FSQ AqueK195~b_Aque --------SYPPDVPE-HFS----EDFKDFLNKCLNNNEYQRYPAHELLVH------PFI AqueK194_Aque DVRKK-EIVFSERFKT-SKK----MSKQAVEHTLQNPNSSQYKRLMEKL--------FSQ AqueK194~b_Aque --------SYPPDVPE-HFS----EDFKDFLNKCLNNNEYQRYPAHELLVH------PFI AqueK193_Aque -----------------------------------------------------------D PEKc_Smoe ELKQQ--NILPSNWAA-KF-----PHQAALVHLLVSPHPQDRPSAREVLQS------ELL PEKa_Smoe ELKQQ--NILPSNWAA-KF-----PHQAALVHLLVSPHPQDRPSARDVLQS------ELL GK065_Glam VLVQN--KQLPSEFTE-THP-----NVSAILYQLCDVHPLKRLTASALIEALSALNLPVI