CLUSTAL W (1.83) multiple sequence alignment RHOK_Hsap FLDFRVLGKGGFGEVSACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILMKVHSRF GPRK7_Hsap FTEFRVLGKGGFGEVCAVQVKNTGKMYACKKLDKKRLKKKGGEKMALLEKEILEKVSSPF GPRK6_Hsap FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRF GPRK5_Hsap FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQF GPRK4_Hsap FRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKVQSRF Gprk2_Dmel FRMYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGESMVLIEKQILQKINSPF GPRK6_Mmus FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRF GPRK5_Mmus FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQF GPRK4_Mmus FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKRILEKLHSRF F19C6.1_Cele FRLYRVLGKGGFGEVCACQVRASGKMYALKKLEKKRVKKRHAETLSLNEKQILQRINSPF RHOK_Mmus FLDFRVLGKGGFGEVSACQMKATGKMYACKKLNKKRLKKRKGYQGAIVEKRILTKVHSRF GPRK_Spur ------------------------------------------------------------ AqueK008_Aque FRQYRVLGKGGFGLVFACQSKFTGKMYALKKLEKKRVKKRKGEKLALNEKEVLEKVDSRF RHOK_Hsap IVSLAYAFETKADLCLVMTIMNGGDIRYHIYNVNEENPGFPEPRALFYTAQIICGLEHLH GPRK7_Hsap IVSLAYAFESKTHLCLVMSLMNGGDLKFHIYNVG--TRGLDMSRVIFYSAQIACGMLHLH GPRK6_Hsap VVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMG--QAGFPEARAVFYAAEICCGLEDLH GPRK5_Hsap VVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMG--NPGFEEERALFYAAEILCGLEDLH GPRK4_Hsap VVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLG--NPGFDEQRAVFYAAELCCGLEDLQ Gprk2_Dmel VVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMG-GEPGFELERARFYAAEVACGLQHLH GPRK6_Mmus VVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMG--QAGFPEARAVFYAAEICCGLEDLH GPRK5_Mmus VVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMG--NPGFEEERALFYAAEILCGLEDLH GPRK4_Mmus VVSLAYTYETKDALCLVLTIMNGGDLKYHIYNLG--DPGFEEPRAVFYAAELCCGLEDLQ F19C6.1_Cele VVSLAYAYETKDALCLVLTLMNGGDLKFHLYNLM--PGGFDEKRVQFYAAEITLGLQHLH RHOK_Mmus IVSLAYAFETKTDLCLVMTIMNGGDVRYHIYNVDEDNPGFSEPRAIYYTAQIISGLEHLH GPRK_Spur ----------KEALCLVLTIMNGGDLKFHIHNMG--SPGFEEERARFYAAEILCGLEDLH AqueK008_Aque VVTLAYAYQSKDSLCMVLTLMNGGDLRFHIYSIG--SPGLEPERVVFYAAEIACGLHHLH * **:*:::*****:::*:: : *: *. :*:*:: *: .*: RHOK_Hsap QRRIVYRDLKPENVLLDNDGNVRISDLGLAVELLDGQSKTKGYAGTPGFMAPELLQ-GEE GPRK7_Hsap ELGIVYRDMKPENVLLDDLGNCRLSDLGLAVEMKGGKP-ITQRAGTNGYMAPEILMEKVS GPRK6_Hsap RERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQT-IKGRVGTVGYMAPEVVK-NER GPRK5_Hsap RENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDL-IRGRVGTVGYMAPEVLN-NQR GPRK4_Hsap RERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQR-VRGRVGTVGYMAPEVVN-NEK Gprk2_Dmel KQGIVYRDCKPENILLDDHGHVRISDLGLAVEIPEGEM-VRGRVGTVGYMAPEVID-NEK GPRK6_Mmus RERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQT-IKGRVGTVGYMAPEVVR-NER GPRK5_Mmus RENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDL-IRGRVGTVGYMAPEVLN-NQR GPRK4_Mmus RKRIVYRDLKPENILLDDHGHIRISDLGLAMEVPEGEM-VRGRVGTVGYMAPEIIN-HEK F19C6.1_Cele SERILYRDLKPENILLDDFGHVRISDLGLAVEIKDNEP-IKGRVGTVGYMAPEIVK-NER RHOK_Mmus QRRIVYRDLKPENVLLDNDGNIRISDLGLAVELKEGQNKTKGYAGTPGFMAPELLR-GEE GPRK_Spur RLRIVYRDMKPENILLDDHGHVRISDLGLAVEIPENDT-IRGRVGTVGYMAPEVVK-NER AqueK008_Aque TARIAYRDMKPDNILLDDAGHIRISDLGLAVHIPEGQS-VRGRVGTPGYMAPEVID-GHR *** **:*:***: *: *:****** .: .. .** *:****:: RHOK_Hsap YDFSVDYFALGVTLYEMIAARGPFRARGEKVENKELKHRIISEPVKY-PDKFSQASKDFC GPRK7_Hsap YSYPVDWFAMGCSIYEMVAGRTPFKDYKEKVSKEDLKQRTLQDEVKFQHDNFTEEAKDIC GPRK6_Hsap YTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEY-SERFSPQARSLC GPRK5_Hsap YGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVY-SHKFSEEAKSIC GPRK4_Hsap YTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEY-SEKFSEDAKSIC Gprk2_Dmel YAFSPDWFSFGCLLYEMIEGQAPFRMRKEKVKREEVDRRVKEDPEKY-SSKFNDEAKSMC GPRK6_Mmus YTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVAEEY-TDRFSSQARSLC GPRK5_Mmus YGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVY-SSKFSEEAKSIC GPRK4_Mmus YTFSPDWWGLGCLIYEMIAGHSPFRKYKEKVNREELERRVKNETEEY-SERFSEDAKSIC F19C6.1_Cele YSYGVDWWGVGCLIYEMIEGKAPFRQRKEKVKREEVERRVREDQEKY-SEKFSEAARTLC RHOK_Mmus YDFSVDYFALGVTLYEMIAARGPFRARGEKVENKELKQRIISEPVKY-PEKFSQASKDFC GPRK_Spur YTFSPDYWGLGCLIYEMIEGRAPFRARKEKVKREEVDRRVKEDDEKY-SQKFSTEAQDIC AqueK008_Aque YTFAPDWWGMGCLIYEMICGRTPFRKHKERVSREDIERRIKDDRVCLDNSAFTEDSRSIC * *::..* :***: .: **: :::. :::.: . *. :: :* RHOK_Hsap EALLEKDPEKRLGFRD-----E--TCDKLRAHPLF GPRK7_Hsap RLFLAKKPEQRLGSRE-----K---SDDPRKHHFF GPRK6_Hsap SQLLCKDPAERLGCRG-----G--SAREVKEHPLF GPRK5_Hsap KMLLTKDAKQRLGCQE-----E--GAAEVKRHPFF GPRK4_Hsap RMLLTKNPSKRLGCRG-----E--GAAGVKQHPVF Gprk2_Dmel QQLLAKSIKQRLGCRN-----GRMGGQDVMAHPFF GPRK6_Mmus SQLLSKDPAERLGCRG-----G--GAREVKEHPLF GPRK5_Mmus NMLLTKDSKQRLGCQE-----E--GAAEVKRHPFF GPRK4_Mmus SMLLIKDPSKRLGCQR-----D--GVSAVKQHPIF F19C6.1_Cele RGLLHKEPGFRLGCRRVGRPED--GAEEIRAHPFF RHOK_Mmus EQLLEKDPEKRLGFRD-----G--TCDALRANVLF GPRK_Spur KKLLQKDPALRMGFEN-----G--TAQTVKDHSFF AqueK008_Aque DQFLDKVHATRLGCCG-----E--MFEDVKAHPFF :* * *:* : .*