CLUSTAL W (1.83) multiple sequence alignment HIPK4_Hsap YDIIEVLGKGTFGEVAKGWRRSTGEMVAIKILKNDAYRNRIIKNELKLLHCMRGLDPEEA HIPK3_Hsap YEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTENADEY HIPK2_Hsap YEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESADDY HIPK1_Hsap YEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEVSILSRLSSENADEY CG17090_Dmel YEVLEFLGRGTFGQVVKCWKRGTSEIVAIKILKNHPSYARQGQIEVSILSRLSQENADEF HIPK4_Mmus YDIIEVLGKGTFGEVAKGWRRSTGEMVAIKILKNDAYRSRIIKNELKLLRCVRGLDPDEA HIPK3_Mmus YEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTENADEY HIPK2_Mmus YEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESADDY HIPK1_Mmus YEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEVSILSRLSSENADEY hpk-1_Cele YEVLEFLGKGTFGQVVKAWKKGTSEIVAIKILKKHPSYARQGQIEVSILSRLSNENSEEF HIPKa_Spur YEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSAENADDF HIPKb_Spur ------------------------------------------------------------ AqueK114_Aque YDVLDRLGRGTFGQVVRAWKKNTSEIVAIKILKSTPSYAKQGQMEVDVLSKLSRLSPDEG HIPK4_Hsap HVIRFLEFFHDALKFYLVFELLEQNLFEFQKENNFAPLPARHIRTVTLQVLTALARLKEL HIPK3_Hsap NFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRPILQQVATALKKLKSL HIPK2_Hsap NFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKSL HIPK1_Hsap NFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVATALMKLKSL CG17090_Dmel NFVRAFECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILEQVLTALLKLKQL HIPK4_Mmus HVIRFLEFFHDALKFYLVFELLEQNLFEFQKENNFAPLPARHIRTVTLQVLRALARLKEL HIPK3_Mmus NFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRPVLQQVATALKKLKSL HIPK2_Mmus NFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKSL HIPK1_Mmus NFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVATALMKLKSL hpk-1_Cele NFVRAFECFNHKSHTCLVFEMLEQNLYDFLKQNKFMPLPLNAIRPILFQVLTALLKLKSL HIPKa_Spur NLVRAYEYFQHKNHTCLVFELLEKNLYDFLKQSKFRPLPLKHIRPTLQQVLVALLKLKTL HIPKb_Spur ------------------------------------------------------------ AqueK114_Aque SFVKAYESFQHHGHICIVFELLHINLYDYLKQSRFDPLPLKYIRPIAQQVLCCLEKLASL HIPK4_Hsap AIIHADLKPENIMLVDQTRCPFRVKVIDFGSASIFSEVRYVKEPYIQSRFYRAPEILLGL HIPK3_Hsap GLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSK--TVCSTYLQSRYYRAPEIILGL HIPK2_Hsap GLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSK--AVCSTYLQSRYYRAPEIILGL HIPK1_Hsap GLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSK--AVCSTYLQSRYYRAPEIILGL CG17090_Dmel GLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSK--TVCNTYLQSRYYRAPEIILGL HIPK4_Mmus AIIHADLKPENIMLVDQTRCPFRVKVIDFGSASIFSEVRYVKEPYIQSRFYRAPEILLGL HIPK3_Mmus GLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSK--TVCSTYLQSRYYRAPEIILGL HIPK2_Mmus GLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSK--AVCSTYLQSRYYRAPEIILGL HIPK1_Mmus GLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSK--AVCSTYLQSRYYRAPEIILGL hpk-1_Cele GLIHADLKPENIMLVDPQQQPYRVKVIDFGSASHRSK--AVTNTYLQSRYYRAPEIILGL HIPKa_Spur GLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSK--AVCSTYLQSRYYR-------- HIPKb_Spur ---------------------------------------------------RAPEIILGL AqueK114_Aque GLVHADLKPENIMLVDPQRYPFKVKVIDFGSAMSRDK--TSPSCYLQSRYYRAPEVILGV * HIPK4_Hsap PFCEKVDVWSLGCVMAELHLGWPLYPGNNEYDQVRYICETQGLPKPHLLHAACKAHHFFK HIPK3_Hsap PFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGEQLLNVGTKSTRFFC HIPK2_Hsap PFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFN HIPK1_Hsap PFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFN CG17090_Dmel PFCEAIDMWSLGCVVAELFLGWPLYPGSSEFDQIRYISQTQGLPTEHMLN---------- HIPK4_Mmus PFCEKVDVWSLGCVMAELHLGWPLYPGNNEYDQVRYICETQGLPKPHLLHAARKAHHFFK HIPK3_Mmus PFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGEQLLNVGTKSTRFFC HIPK2_Mmus PFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFN HIPK1_Mmus PFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFN hpk-1_Cele PFNESIDMWSLGCVIAELFLGWPLYPGSSEYDQIRFIIQTQGLPPTSMLESASKLHRFFK HIPKa_Spur ------------------------------------------------------------ HIPKb_Spur PFCEAIDMWSLGCVVAELFLGWPLYPGASEYDQIRYISQTQGLPAEHLLSAATKTTRFFK AqueK114_Aque NFNEGIDMWSLGCVLAELYLGWPLFPGASEFDQITYICQTLGPLPHHLMRNITKATRFFN HIPK4_Hsap RN-------PHPDAANPWQLKSSADYLAET-KVRPLERRKYMLKSLDQIETVN-GGSVAS HIPK3_Hsap KE-------TDM-SHSGWRLKTLEEHEAET-GMKSKEARKYIFNSLDDVAHVN-TV---- HIPK2_Hsap RD-------TDS-PYPLWRLKTPDDHEAET-GIKSKEARKYIFNCLDDMAQVN-MT---- HIPK1_Hsap RD-------PNL-GYPLWRLKTPEEHELET-GIKSKEARKYIFNCLDDMAQVN-MS---- CG17090_Dmel ------------------------------------------------------------ HIPK4_Mmus RN-------PHPDATNPWQLKSSADYLAET-KVRPLERRKYMLKSLDQIETVN-GGGAVS HIPK3_Mmus RE-------TDM-SHSGWRLKTLEEHEAET-GMKSKEARKYIFNSLDDIVHVN-TV---- HIPK2_Mmus RD-------TDS-PYPLWRLKTPDDHEAET-GIKSKEARKYIFNCLDDMAQVN-MT---- HIPK1_Mmus RD-------PNL-GYPLWRLKTPEEHELET-GIKSKEARKYIFNCLDDMAQVN-MS---- hpk-1_Cele EVKSESPNHTNV-GGSYYRLKTVEEYEASSSTAKSKETRKYIFNVIDDISRVC-YG---- HIPKa_Spur ------------------------------------------------------------ HIPKb_Spur RD-------IES-NFPLWRLKNPEEHETET-SVKSKEARKYIFNCLDDIAGVN-LP---- AqueK114_Aque CD-------PV---TSTWSLKSISQYTQET-GIQSKESRKYIFRSLLDMNHLPPLA---- HIPK4_Hsap RLTFPDREALAEHADLKSMVELIKRMLTWESHERISPSAALRHPFV HIPK3_Hsap -MDLEGSDLLAEKADRREFVSLLKKMLLIDADLRITPAETLNHPFV HIPK2_Hsap -TDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPFV HIPK1_Hsap -TDLEGTDMLAEKADRREYIDLLKKMLTIDADKRITPLKTLNHQFV CG17090_Dmel ---------------SREFIDLLKRMLTIDQERRLTPAEALNHSFT HIPK4_Mmus RLSFPDREALAEHADLKSMVELIKRMLTWESHERISPSAALRHPFV HIPK3_Mmus -MDLEGGDLLAEKADRREFVNLLKKMLLIDADLRITPIETLNHPFV HIPK2_Mmus -TDLEGSDMLVEKADRREFIDLLKKMLTIDADKRVTPIETLNHPFV HIPK1_Mmus -TDLEGTDMLAEKADRREYIDLLKKMLTIDADKRITPLKTLNHQFV hpk-1_Cele -FESDPVEHLCDRIDRQEFVDVLKKMLVLNPDFRITPAEGLESKFV HIPKa_Spur ---------------------------------------------C HIPKb_Spur -TDLEGSDYLAEKADRREFVELLKKMLTIDPDKRITPLEALNHPFV AqueK114_Aque -AGIDNREAILTSVDRMEFISLLSRMLSLDPTQRIRPLSALQSPFI