CLUSTAL W (1.83) multiple sequence alignment LKB1_Hsap YLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRHK CG9374_Dmel YIMGDVLGEGSYGKVKEAMNSENLCRLAVKILTKRKLRRIPNGEQNVTREIALLKQLKHR LKB1_Mmus YLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRHR par-4_Cele YMWGGQIGTGSYGKVKECIDMYTLTRRAVKIMKYDKLRKITNGWENIRSEMSILRRMNHR Lkb1_Ddis YILGEVLGEGAYGKVKDGMDSFTQKRVAVKILKRARLKKIPGGEASVLKEINITKKLHNK LKB1_Spur YLMGDTLGEGSYGKVKEALDSESLCRRAVKILKKKKLKRIPCGEQNVKREIQLLKRLNHP AqueK062_Aque AKIGDLLGVGAYSKVREMLDCVTLCRRAVKIMKQRRLSRILNGEENVRREIKILKKLNHR * :* *:*.**:: :: . * ****:. :* :* * .: *: : :::.: LKB1_Hsap NVIQLVDVLYNEEKQKMYMVMEYCVCGM-QEMLDSVPEKRFPVCQAHGYFCQLIDGLEYL CG9374_Dmel HVVELVDVLYNEEKQKMYLVMEYCVGGL-QEMIDYQPDKRMPLFQAHGYFKQLVDGLEYL LKB1_Mmus NVIQLVDVLYNEEKQKMYMVMEYCVCGM-QEMLDSVPEKRFPVCQAHGYFRQLIDGLEYL par-4_Cele NVIKLIEIFNIPAKGKVYMVFEYCIGSV-QQLLDMEPARRLTIGESHAIFIELCQGLNYL Lkb1_Ddis HIIKLIDHFIIEEKGKLYIVYEYVGGGTSQNILENAPNGRLPPHQSQFIFRQLIEACEYI LKB1_Spur NIIQLVEVLQNDEKQKMYLFMEYCVSGL-QDMLDAAECKKFPIWQANDYFCQLVDGLEYL AqueK062_Aque NVIKLLDVFSDDNKQKLYIVLEYCVGGL-QEMLDKAPRNKFPIWQAHKYFVQLIEGLEYL ::::*:: : * *:*:. ** . *:::: ::. ::: * :* :. :*: LKB1_Hsap HSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHPFAADDTCRTSQGSPAFQPPEIANG CG9374_Dmel HSCRVIHKDIKPGNLLLSLDQTLKISDFGVAEQLDLFAPDDTCTTGQGSPAFQPPEIANG LKB1_Mmus HSQGIVHKDIKPGNLLLTTNGTLKISDLGVAEALHPFAVDDTCRTSQGSPAFQPPEIANG par-4_Cele HSKRVSHKDIKPGNLLVSIDFTVKICDFGVAEQINLFQRDGRCTKVNGTPKFQPPECIYG Lkb1_Ddis HSQKILHRDIKPDNILFTHANVLKLSDFGVAEDSSQLEDFECLSRSYGSPAFQPPELTQF LKB1_Spur HSQHVVHKDIKPSNLLLTTAGILKISDFGVAELLDHFTEDDACRTSQGSPAFQPPEIANG AqueK062_Aque HSCGIVHKDIKPGNLLLTTDDVVKISDFGVAEELDRFSQSDRCCNFQGSPAFQSPEIASG ** : *:****.*:*.: :*:.*:**** : *:* **.** LKB1_Hsap -LDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPG---DCGPPLS CG9374_Dmel -HETFAGFKVDIWSSGVTLYNLATGQYPFEGDNIYRLLENIGRGQWEAPAWLYEMDADFA LKB1_Mmus -LDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGRGDFTIPC---DCGPPLS par-4_Cele NHDFFDGYKADMWSAGVTLYNLVSGKYPFEKPVLLKLYECIGTEPLQMPTNV-QLTKDLQ Lkb1_Ddis -QTTFSPFKIDIWAMGVTLYLMTIGKFPFSGANMFVLFENISKCKIEFPN---DLDKDLV LKB1_Spur -QDVFSGFKVDIWSSGITLYNIVTGKFPFEGDNIYRLFENIGKGDYTIPA---DVPPQLT AqueK062_Aque -QDNWSGFKADIWASGVTLYHFTTGKFPFEGESVYKLFAVISQCTYTLPPE---LPPVLQ : :* *:*: *:*** :. * :**. : * *. * : LKB1_Hsap DLLKGMLEYEPAKRFSIRQIRQHSWF CG9374_Dmel NLILGMLQADPSKRLSLQEIRHDTWF LKB1_Mmus DLLRGMLEYEPAKRFSIRQIRQHSWF par-4_Cele DLLTKLLEKDFNERPTCLETMIHPWF Lkb1_Ddis NLIKGILQVDHIQRFSLGQIKNHP-W LKB1_Spur NLLEGMLSIDPDTRLNVHQIKEHVWV AqueK062_Aque DLIRGMLLKDPDKRLDIEQIRRHTWF :*: :* : * : .