CLUSTAL W (1.83) multiple sequence alignment mek-2_Cele lqtegelghgnggvvnkcvhrktgvimarklvhleikpsvrqqivkelav--lhkcnspf Dsor1_Dmel LEKLGELGSGNGGVVMKVRHTHTHLIMARKLIHLEVKPAIKKQILRELKV--LHECNFPH MAP2K1_Mmus FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQV--LHECNSPY MAP2K2_Mmus FERISELGAGNGGVVTKARHRPSGLIMARKLIHLEIKPAVRNQIIRELQV--LHECNSPY MAP2K1_Hsap FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQV--LHECNSPY MAP2K2_Hsap FERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQV--LHECNSPY MEK_Spur FEVLKELGAGNGGVVTKVKHKMSGMVMARKLIKLEIKPAIRNQIIRELKV--LHECNSPY CC1G_02205_Ccin LKKLSDLGQGNGGSVEKVEHLPTGTIMAKKSVLIDAKSSVRKQILRELDI--MHECQSDY CC1G_03368_Ccin LVDIHDLGQGNGGSVKKVEHTPTKMIMAKKTVLIDAKPSVRKQILRELHI--MHDCRSDY AqueK243_Aque FERLSELGHGNGGVVLKVMHKPSGIIMARKMILLDIKPTVRNQIMRELKV--LHDCNASY GK083_Glam LEVVKPLGAGAFGTVNLVKVKTTGQLCAMKEIRISDEEQTQKNIYREIKASISLSCN-PY : ** * * * : : * * : :. : :::* :*: .*. . mek-2_Cele ivgfygafvdnndi-sicmeymdglsldivlkkv--grlpekfvgrisvavvrgltylkd Dsor1_Dmel IVGFYGAFYSDGEI-SICMEYMDGGSLDLILKRA--GRIPESILGRITLAVLKGLSYLRD MAP2K1_Mmus IVGFYGAFYSDGEI-SICMEHMDGGSLDQVLKKA--GRIPEQILGKVSIAVIKGLTYLRE MAP2K2_Mmus IVGFYGAFYSDGEI-SICMEHMDGGSLDQVLKEA--KRIPEDILGKVSIAVLRGLAYLRE MAP2K1_Hsap IVGFYGAFYSDGEI-SICMEHMDGGSLDQVLKKA--GRIPEQILGKVSIAVIKGLTYLRE MAP2K2_Hsap IVGFYGAFYSDGEI-SICMEHMDGGSLDQVLKEA--KRIPEEILGKVSIAVLRGLAYLRE MEK_Spur IVGFFGAYYSDGEI-CICMENMDGGSLDQVMKSAPKGRIPENILGKVTVAVLRGLIYLRD CC1G_02205_Ccin IISCFGSFLAEPNI-CICMEFMDKGSFDGIYKKL--GPLQVEVVGMVALSVLEGLTYLYD CC1G_03368_Ccin IISFYGAFLADNNI-CICMEFMDKGSLDGIYKKI--GAIDIDIVGKIALAVLEGLTYLYD AqueK243_Aque IVGFFGSFHVNNEI-SILMQHMDGGSLDLVLN-T--GRIPVDMIGQITVAVLNGLKYLRD GK083_Glam MVKTYNIYSHPGSILHILLEFCKYGSSQDMLKKLKTGKLTENALAVFIIDTLRGLAYLHD :: :. : .* * :: . * : : : : . :. . : .:.** ** : mek-2_Cele eikilhrdvkpsnmlvnsngeiklcdfgvsgmlid----smansfvgtrsymaperlt-- Dsor1_Dmel NHAIIHRDVKPSNILVNSSGEIKICDFGVSGQLID----SMANSFVGTRSYMSPERLQ-- MAP2K1_Mmus KHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID----SMANSFVGTRSYMSPERLQ-- MAP2K2_Mmus KHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID----SMANSFVGTRSYMSPERLQ-- MAP2K1_Hsap KHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID----SMANSFVGTRSYMSPERLQ-- MAP2K2_Hsap KHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID----SMANSFVGTRSYMAPERLQ-- MEK_Spur VHDIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID----SMANSFVGTRSYMSPERLQ-- CC1G_02205_Ccin VHRIMHRDIKPSNILFNSQGQIKLCDFGVSGEVIN----SIANTFVGTSVYMSPERIQSH CC1G_03368_Ccin VHRIIHRDIKPSNILCNSRGQIKICDFGVSGELIN----SIADTFVGTSTYMSPERIQ-- AqueK243_Aque THHIIHRDVKPSNILVNSEGEIKLCDFGVSGQLIN----SMANSFVGTRSYMAPERLQ-- GK083_Glam NCKIIHRDIKSANILIDEHGYCKLADFGVASSVLPNDDEAAMKTFVGSLSYMSPERIQ-- *:***:*.:*:* :. * *:.****:. :: : .:***: **:***: mek-2_Cele gshytissdiwsfglslvelligrypvpapsqaeyatmfnvaen---eieladslee--- Dsor1_Dmel GTHYSVQSDIWSLGLSLVEMAIGMYPIPPPNTATLESIFADNAEES--GQ---------- MAP2K1_Mmus GTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELLFGCHV----EGDAAETPPR--- MAP2K2_Mmus GTHYSVQSDIWSMGLSLVELAIGRYPIPPPDAKELEASFGRPVVDGADGEPHSVSPR--- MAP2K1_Hsap GTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQV----EGDAAETPPR--- MAP2K2_Hsap GTHYSVQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDGEEGEPHSISPR--- MEK_Spur GTHYTVQSDIWSLGLSLVEMAIGRYPIPAPDETALANLFGYELQA---GETKN-IRK--- CC1G_02205_Ccin GDGYSVKSDVWSLGMSLVELALGAFPFTDPPDDDDDDL-SDLEG--DS---SSPSPSDAQ CC1G_03368_Ccin GAQYTVKSDVWSLGISLIELALGRFPFSQSDSDESDDEFSDASD--YEGT-LSPQPAGSV AqueK243_Aque GEVYSVLSDIWSLGVSLIEMAIGSYPIPAPPKEQLDEEMRNPP----AG----SL-P--- GK083_Glam NQPYSYVSDVWSMGLTYVELLTGSYPYDNV------------------------------ . *: **:**:*:: :*: * :* mek-2_Cele --pn-----------------------yh-p---psnpasmaifemldyivngppptl-p Dsor1_Dmel ---------------------------------PTDEPRAMAIFELLDYIVNEPPPKL-E MAP2K1_Mmus --PR------------------TPGRPLS-SY-GMDSRPPMAIFELLDYIVNEPPPKL-P MAP2K2_Mmus --PR------------------PPGRPISVGH-GMDSRPAMAIFELLDYIVNEPPPKL-P MAP2K1_Hsap --PR------------------TPGRPLS-SY-GMDSRPPMAIFELLDYIVNEPPPKL-P MAP2K2_Hsap --PR------------------PPGRPVS-GH-GMDSRPAMAIFELLDYIVNEPPPKL-P MEK_Spur --TR-----------------------VG-GV-FSDSPRPMAIFELLNYIVEEHPPRL-P CC1G_02205_Ccin -HQRTPTHRDSFLLSKKTAKRASKRRSKL-TYNPDGQLSTMSIFELIHQIVQEPSPRL-P CC1G_03368_Ccin SLADLP--------------PPKPRRQKN-AN-GNGSTTKKDKRKSKGHIVNEPAPRLTP AqueK243_Aque --PR--------------------RNPYA-S---HANAIRMPVFELLQMIFTDDPPRL-P GK083_Glam ----------------------------------------NSFWDAMNVIVNGAPPLL-K . *. .* * mek-2_Cele k-rfftdevigfvskclrklpseratlkslt--advff Dsor1_Dmel H-KIFSTEFKDFVDICLKKQPDERADLKTLL--SHPWI MAP2K1_Mmus S-GVFSLEFQDFVNKCLIKNPAERADLKQLM--VHAFI MAP2K2_Mmus S-GVFSSDFQEFVNKCLIKNPAERADLKLLM--NHAFI MAP2K1_Hsap S-GVFSLEFQDFVNKCLIKNPAERADLKQLM--VHAFI MAP2K2_Hsap N-GVFTPDFQEFVNKCLIKNPAERADLKMLT--NHTFI MEK_Spur S-RAFSEEFVDFVDVCLIKNPNERADLKKLK--VHTFA CC1G_02205_Ccin S-DKFPADAVDLVDICLLKNPEERQTPKALLVRNHPWI CC1G_03368_Ccin E-GRYPKAAESFIDACLLKDPDARQTPKDLL--KHEWI AqueK243_Aque D-EYFDDKFKSFVALCLQKDVKKRGTLSALL--EHKFV GK083_Glam EDAGYSPGLCDLVNAMLEKDPSKRMTAAQLL--KLPFC : :: * * * * :