CLUSTAL W (1.83) multiple sequence alignment MLK4_Hsap LELKELIGAGGFGQVYRATWQ--------------GQEVAVKAAR------QDP--EQD- MLK3_Hsap LRLEEVIGIGGFGKVYRGSWR--------------GELVAVKAAR------QDP--DED- MLK2_Hsap LQLEEIIGVGGFGKVYRALWR--------------GEEVAVKAAR------LDP--EKD- MLK1_Hsap LTLEEIIGIGGFGKVYRAFWI--------------GDEVAVKAAR------HDP--DED- slpr_Dmel LDIKEVIGSGGFCKVHRGYYD--------------GEEVAIKIAH------QTG--EDD- MLK4_Mmus LELKELIGAGGFGQVYRATWQ--------------GQEVAVKAAR------RDP--EQD- MLK3_Mmus LRLEEVIGIGGFGKVYRGSWR--------------GELVAVKAAR------QDP--DED- MLK2_Mmus LQLEEIIGVGGFGKVYRAVWR--------------GEEVAVKAAR------LDP--ERD- MLK1_Mmus LTLEEIIGIGGFGKVYRAFWA--------------GDEVAVKAAR------HDP--DED- K11D12.10_Cele TLSDCQIGHGATATVFKMDIKIKKELQNGRMGEAVGDQMKAALKR---FNRHASNFRADV MLK_Spur ------------------------------------------------------------ AqueK658_Aque VEIGEAIEKGAYSSTVRVRWQ--------------GTEYRGNKLHDVHLR-LEK--KKG- AqueK659_Aque IKLGDVIGLGGFGKVYRAQYK--------------GEDVAVKVAR------HTT---YD- MLK4_Hsap --AAAAAESVRREARLFAMLRHPNIIELRGVCLQQ---PHLCLVLEFARGGALNRALAAA MLK3_Hsap --ISVTAESVRQEARLFAMLAHPNIIALKAVCLEE---PNLCLVMEYAAGGPLSRALAG- MLK2_Hsap --PAVTAEQVCQEARLFGALQHPNIIALRGACLNP---PHLCLVMEYARGGALSRVLAG- MLK1_Hsap --ISQTIENVRQEAKLFAMLKHPNIIALRGVCLKE---PNLCLVMEFARGGPLNRVLSG- slpr_Dmel --MQRMRDNVLQEAKLFWALKHENIAALRGVCLNT----KLCLVMEYARGGSLNRILAG- MLK4_Mmus --AAAAAESVRREARLFAMLRHPNIIQLRGVCLRQ---PHLCLVLEFARGGALNRALAAA MLK3_Mmus --ISVTAESVRQEARLFAMLAHPNIIALKAVCLEE---PNLCLVMEYAAGGPLSRALAG- MLK2_Mmus --PAVTAEQVRQEARLFGALQHPNIIALRGACLSP---PNLCLVMEYARGGALSRVLAG- MLK1_Mmus --ISQTIENVRQEAKLFAMLKHPNIIALRGVCLKE---PNLCLVMEFARGGPLNRVLSG- K11D12.10_Cele VSTDEQLEQLKREANLVNGLSHNNIVRLLGICLED---PYFGLLLELCEGSSLRNVCRNL MLK_Spur ------------------------------------------------------------ AqueK658_Aque --GEELLGRLRRHCELVFSLNHPNLVQHIGVALSTQDGPAPILITPSLPTNLANIISAN- AqueK659_Aque --TMKAVSDVLSEAEKFAHLAHENVCALIGVCLVK----DVCLVMEYAKGGPLSKILHE- MLK4_Hsap NAAPDPRAPGPRRARRI--PPHVLVNWAVQIARGMLYLHEEAFVPILHRDLKSSNILLLE MLK3_Hsap --------------RRV--PPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQ MLK2_Hsap --------------RRV--PPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILE MLK1_Hsap --------------KRI--PPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQ slpr_Dmel ---------------KI--PPDVLVNWAIQIARGMNYLHNEAPMSIIHRDLKSSNVLIYE MLK4_Mmus AS--DPRAPGPRRARRI--PPQVLVNWAVQIARGMLYLHEEAVVPILHRDLKSSNILLLE MLK3_Mmus --------------RRV--PPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQ MLK2_Mmus --------------RRV--PPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILE MLK1_Mmus --------------KRI--PPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQ K11D12.10_Cele -----------NSDAAI--PLGVLIDWATQVAEGMEYLTKQG---YVHRDLKADNVLVKE MLK_Spur ------------------------------------------------------------ AqueK658_Aque --------------TRL--PPAVSHSILRDVSQGLAYLHNRPKAPVPHGSLSANNVLLTR AqueK659_Aque --------------RNITLTVDIILDWSRQITEGMEYLHHEITPSLIHRDLKSSNILLQY MLK4_Hsap KIE-----------------HDDICNKTLKITDFGLAREWH-RTTKMS------------ MLK3_Hsap PIE-----------------SDDMEHKTLKITDFGLAREWH-KTTQMS------------ MLK2_Hsap AIE-----------------NHNLADTVLKITDFGLAREWH-KTTKMS------------ MLK1_Hsap KVE-----------------NGDLSNKILKITDFGLAREWH-RTTKMS------------ slpr_Dmel AIE-----------------GNHLQQKTLKITDFGLAREMY-NTQRMS------------ MLK4_Mmus KIE-----------------HDDICNKTLKITDFGLAREWH-RTTRMS------------ MLK3_Mmus PIE-----------------GDDMEHKTLKITDFGLAREWH-KTTQMS------------ MLK2_Mmus AIE-----------------NHNLADTVLKITDFGLAREWH-KTTKMS------------ MLK1_Mmus KVE-----------------NGDLSNKILKITDFGLAREWH-RTTKMS------------ K11D12.10_Cele EVCLCMDEEMFQYAYCLKCGKRPFDKLQLKITDFGVTRKMTADANRFS------------ MLK_Spur ---------------------------QLKITDFGLAREMY-KTTRMS------------ AqueK658_Aque GLE-----------------A--------KLSNLGVAAILE-SGSGGGSKGAAIIAHTKT AqueK659_Aque EVN-----------------PADLKGNLIKITDFGLAREIE-NTTHLS------------ *::::*:: . MLK4_Hsap -TAGTYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDGLAVAYGVAVNKLT MLK3_Hsap -AAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLT MLK2_Hsap -AAGTYAWMAPEVIRLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLT MLK1_Hsap -AAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLA slpr_Dmel -AAGTYAWMPPEVISVSTYSKFSDVWSYGVLLWELITGETPYKGFDPLSVAYGVAVNTLT MLK4_Mmus -AAGTYAWMAPEVIRSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDGLAVAYGVAVNKLT MLK3_Mmus -AAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLT MLK2_Mmus -AAGTYAWMAPEVIRLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLT MLK1_Mmus -AAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLA K11D12.10_Cele -TAGTYAWLAPEAFKEGTWSEASDVWSYGVVLWELLTREEPYQGHIPATIAFQIANKGQN MLK_Spur -AAGTYAWMAPEVIKSSLFSKSSDVWSFGILLWELLTGEVPYKGIDTLAVAYGIAVNKLT AqueK658_Aque PEQTCYA-PPPE---EQPLTMAGDVFSFGVLVLHILSGKYP------------------- AqueK659_Aque -GAGTYPWMAPEVIKSSEFSKKSDVWSFGVVLWEILTGEKPYSGLDMFVVAYGVGHGTLT *. .** : .*::*:*::: .::: : * MLK4_Hsap LPIPSTCPEPFAKLMKECWQQDPHIRPSFALILEQ---L MLK3_Hsap LPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQ---L MLK2_Hsap LPIPSTCPEPFARLLEECWDPDPHGRPDFGSILKRLEVI MLK1_Hsap LPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQ---L slpr_Dmel LPIPKTCPETWGALMKSCWQTDPHKRPGFKEILKQ---L MLK4_Mmus LPIPSTCPEPFAKLMKECWEQDPHIRPSFALILQQ---L MLK3_Mmus LPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQ---L MLK2_Mmus LPIPSTCPEPFARLLEECWDPDPHGRPDFGSILKQLEVI MLK1_Mmus LPIPSTCPEPFAKLMEDCWNPDPHSRPSFTSILDQ---L K11D12.10_Cele LSIGDSCPDRWKKLMQDCWNLEPNFRPKFSTLAIS---F MLK_Spur LPIPSTCPEIFSKMLLDCWNYDPHERPTFSEIMQQ---L AqueK658_Aque --------------------------------------- AqueK659_Aque LPIPEHCPLSLRDLMSCCWKREHSKRPSFTQVKEKL-VE