CLUSTAL W (1.83) multiple sequence alignment PAK3_Hsap ------------------------------------------------------------ PAK2_Hsap ------------------------------------------------------------ PAK1_Hsap ------------------------------------------------------------ PAK3_Mmus ------------------------------------------------------------ PAK2_Mmus ------------------------------------------------------------ PAK1_Mmus ------------------------------------------------------------ pak-1_Cele ------------------------------------------------------------ STE20_Scer ------------------------------------------------------------ SKM1_Scer ------------------------------------------------------------ CLA4_Scer ------------------------------------------------------------ Pak3_Dmel ------------------------------------------------------------ Pak_Dmel ------------------------------------------------------------ Y38F1A.10_Cele ------------------------------------------------------------ PakA_Ddis ------------------------------------------------------------ PakB_Ddis ------------------------------------------------------------ PakC_Ddis ------------------------------------------------------------ PakD_Ddis ------------------------------------------------------------ 19075_Tthe ------------------------------------------------------------ 25909_Tthe ------------------------------------------------------------ PAK1_Spur ------------------------------------------------------------ CC1G_15304_Ccin KRPQSRGKEKALSFLKFGKRSPKSPPTKDASWDSAVPPLPSNGDDGISTPFNFQHNIHVN CC1G_00840_Ccin ------------------------------------------------------------ CC1G_02087_Ccin ------------------------------------------------------------ AqueK235_Aque ------------------------------------------------------------ GK081_Glam ------------------------------------------------------------ PAK3_Hsap ------------------------------------------------------------ PAK2_Hsap ------------------------------------------------------------ PAK1_Hsap ------------------------------------------------------------ PAK3_Mmus ------------------------------------------------------------ PAK2_Mmus ------------------------------------------------------------ PAK1_Mmus ------------------------------------------------------------ pak-1_Cele ------------------------------------------------------------ STE20_Scer ------------------------------------------------------------ SKM1_Scer ------------------------------------------------------------ CLA4_Scer ------------------------------------------------------------ Pak3_Dmel ------------------------------------------------------------ Pak_Dmel ------------------------------------------------------------ Y38F1A.10_Cele ------------------------------------------------------------ PakA_Ddis ------------------------------------------------------------ PakB_Ddis ------------------------------------------------------------ PakC_Ddis ------------------------------------------------------------ PakD_Ddis ------------------------------------------------------------ 19075_Tthe ------------------------------------------------------------ 25909_Tthe ------------------------------------------------------------ PAK1_Spur ------------------------------------------------------------ CC1G_15304_Ccin EGLVGLPPTWSAALSQAGFSDEEIIAIHNRRAAGSRSPNSQYVLNARPPSPRIPHPYQQS CC1G_00840_Ccin ------------------------------------------------------------ CC1G_02087_Ccin ------------------------------------------------------------ AqueK235_Aque ------------------------------------------------------------ GK081_Glam ------------------------------------------------------------ PAK3_Hsap ------------------------------------------------------------ PAK2_Hsap ------------------------------------------------------------ PAK1_Hsap ------------------------------------------------------------ PAK3_Mmus ------------------------------------------------------------ PAK2_Mmus ------------------------------------------------------------ PAK1_Mmus ------------------------------------------------------------ pak-1_Cele ------------------------------------------------------------ STE20_Scer ------------------------------------------------------------ SKM1_Scer ------------------------------------------------------------ CLA4_Scer ------------------------------------------------------------ Pak3_Dmel ------------------------------------------------------------ Pak_Dmel ------------------------------------------------------------ Y38F1A.10_Cele ------------------------------------------------------------ PakA_Ddis ------------------------------------------------------------ PakB_Ddis ------------------------------------------------------------ PakC_Ddis ------------------------------------------------------------ PakD_Ddis ------------------------------------------------------------ 19075_Tthe ------------------------------------------------------------ 25909_Tthe ------------------------------------------------------------ PAK1_Spur ------------------------------------------------------------ CC1G_15304_Ccin ASNVPIIAQPGPRTTSLPRQVSDASLRSTSTRQRHPIPFGSPASASTASLHSSNAGSISN CC1G_00840_Ccin ------------------------------------------------------------ CC1G_02087_Ccin ------------------------------------------------------------ AqueK235_Aque ------------------------------------------------------------ GK081_Glam ------------------------------------------------------------ PAK3_Hsap ------------------------------------------------------------ PAK2_Hsap ------------------------------------------------------------ PAK1_Hsap ------------------------------------------------------------ PAK3_Mmus ------------------------------------------------------------ PAK2_Mmus ------------------------------------------------------------ PAK1_Mmus ------------------------------------------------------------ pak-1_Cele ------------------------------------------------------------ STE20_Scer ------------------------------------------------------------ SKM1_Scer ------------------------------------------------------------ CLA4_Scer ------------------------------------------------------------ Pak3_Dmel ------------------------------------------------------------ Pak_Dmel ------------------------------------------------------------ Y38F1A.10_Cele ------------------------------------------------------------ PakA_Ddis ------------------------------------------------------------ PakB_Ddis ------------------------------------------------------------ PakC_Ddis ------------------------------------------------------------ PakD_Ddis ------------------------------------------------------------ 19075_Tthe ------------------------------------------------------------ 25909_Tthe ------------------------------------------------------------ PAK1_Spur ------------------------------------------------------------ CC1G_15304_Ccin IKAVRQGASQDHSSRNHTPQLSISYSSDSNHSGVSGEDVYQQSRNGNFPKDVSTPPGKPA CC1G_00840_Ccin ------------------------------------------------------------ CC1G_02087_Ccin ------------------------------------------------------------ AqueK235_Aque ------------------------------------------------------------ GK081_Glam ------------------------------------------------------------ PAK3_Hsap ------------------------------------------------------------ PAK2_Hsap ------------------------------------------------------------ PAK1_Hsap ------------------------------------------------------------ PAK3_Mmus ------------------------------------------------------------ PAK2_Mmus ------------------------------------------------------------ PAK1_Mmus ------------------------------------------------------------ pak-1_Cele ------------------------------------------------------------ STE20_Scer ------------------------------------------------------------ SKM1_Scer ------------------------------------------------------------ CLA4_Scer ------------------------------------------------------------ Pak3_Dmel ------------------------------------------------------------ Pak_Dmel ------------------------------------------------------------ Y38F1A.10_Cele ------------------------------------------------------------ PakA_Ddis ------------------------------------------------------------ PakB_Ddis ------------------------------------------------------------ PakC_Ddis ------------------------------------------------------------ PakD_Ddis ------------------------------------------------------------ 19075_Tthe ------------------------------------------------------------ 25909_Tthe ------------------------------------------------------------ PAK1_Spur ------------------------------------------------------------ CC1G_15304_Ccin HAANPSIAQSFMSQASSLLNGHSHNRNESNASSTSKRLFGSQPSLWSSPSSSSTASRPQT CC1G_00840_Ccin ------------------------------------------------------------ CC1G_02087_Ccin ------------------------------------------------------------ AqueK235_Aque ------------------------------------------------------------ GK081_Glam ------------------------------------------------------------ PAK3_Hsap ------------------------------------------------------------ PAK2_Hsap ------------------------------------------------------------ PAK1_Hsap ------------------------------------------------------------ PAK3_Mmus ------------------------------------------------------------ PAK2_Mmus ------------------------------------------------------------ PAK1_Mmus ------------------------------------------------------------ pak-1_Cele ------------------------------------------------------------ STE20_Scer ------------------------------------------------------------ SKM1_Scer ------------------------------------------------------------ CLA4_Scer ------------------------------------------------------------ Pak3_Dmel ------------------------------------------------------------ Pak_Dmel ------------------------------------------------------------ Y38F1A.10_Cele ------------------------------------------------------------ PakA_Ddis ------------------------------------------------------------ PakB_Ddis ------------------------------------------------------------ PakC_Ddis ------------------------------------------------------------ PakD_Ddis ------------------------------------------------------------ 19075_Tthe ------------------------------------------------------------ 25909_Tthe ------------------------------------------------------------ PAK1_Spur ------------------------------------------------------------ CC1G_15304_Ccin AANTSTSSNHSNAAVTQPTDNNASPEASPPQPKRTNALPPRLSLHQASGSGDLSAWAGML CC1G_00840_Ccin ------------------------------------------------------------ CC1G_02087_Ccin ------------------------------------------------------------ AqueK235_Aque ------------------------------------------------------------ GK081_Glam ------------------------------------------------------------ PAK3_Hsap ------------------------------------------------------------ PAK2_Hsap ------------------------------------------------------------ PAK1_Hsap ------------------------------------------------------------ PAK3_Mmus ------------------------------------------------------------ PAK2_Mmus ------------------------------------------------------------ PAK1_Mmus ------------------------------------------------------------ pak-1_Cele ------------------------------------------------------------ STE20_Scer ------------------------------------------------------------ SKM1_Scer ------------------------------------------------------------ CLA4_Scer ------------------------------------------------------------ Pak3_Dmel ------------------------------------------------------------ Pak_Dmel ------------------------------------------------------------ Y38F1A.10_Cele ------------------------------------------------------------ PakA_Ddis ------------------------------------------------------------ PakB_Ddis ------------------------------------------------------------ PakC_Ddis ------------------------------------------------------------ PakD_Ddis ------------------------------------------------------------ 19075_Tthe ------------------------------------------------------------ 25909_Tthe ------------------------------------------------------------ PAK1_Spur ------------------------------------------------------------ CC1G_15304_Ccin LSGLSSDLDDKLTLGPSPLGPTPLTPQSAPASAATQGPSSFTVSNRPTHTSHSRSLGGES CC1G_00840_Ccin ------------------------------------------------------------ CC1G_02087_Ccin ------------------------------------------------------------ AqueK235_Aque ------------------------------------------------------------ GK081_Glam ------------------------------------------------------------ PAK3_Hsap ------------------------------------------------------------ PAK2_Hsap ------------------------------------------------------------ PAK1_Hsap ------------------------------------------------------------ PAK3_Mmus ------------------------------------------------------------ PAK2_Mmus ------------------------------------------------------------ PAK1_Mmus ------------------------------------------------------------ pak-1_Cele ------------------------------------------------------------ STE20_Scer ------------------------------------------------------------ SKM1_Scer ------------------------------------------------------------ CLA4_Scer ------------------------------------------------------------ Pak3_Dmel ------------------------------------------------------------ Pak_Dmel ------------------------------------------------------------ Y38F1A.10_Cele ------------------------------------------------------------ PakA_Ddis ------------------------------------------------------------ PakB_Ddis ------------------------------------------------------------ PakC_Ddis ------------------------------------------------------------ PakD_Ddis ------------------------------------------------------------ 19075_Tthe ------------------------------------------------------------ 25909_Tthe ------------------------------------------------------------ PAK1_Spur ------------------------------------------------------------ CC1G_15304_Ccin SKARPEPLSELEEPIDNDAQYANLSPPWTGDAGSSSPLWSEIEGILSQGRSPTASEDRHE CC1G_00840_Ccin ------------------------------------------------------------ CC1G_02087_Ccin ------------------------------------------------------------ AqueK235_Aque ------------------------------------------------------------ GK081_Glam ------------------------------------------------------------ PAK3_Hsap ------------------------------------------------------------ PAK2_Hsap ------------------------------------------------------------ PAK1_Hsap ------------------------------------------------------------ PAK3_Mmus ------------------------------------------------------------ PAK2_Mmus ------------------------------------------------------------ PAK1_Mmus ------------------------------------------------------------ pak-1_Cele ------------------------------------------------------------ STE20_Scer ------------------------------------------------------------ SKM1_Scer ------------------------------------------------------------ CLA4_Scer ------------------------------------------------------------ Pak3_Dmel ------------------------------------------------------------ Pak_Dmel ------------------------------------------------------------ Y38F1A.10_Cele ------------------------------------------------------------ PakA_Ddis ------------------------------------------------------------ PakB_Ddis ------------------------------------------------------------ PakC_Ddis ------------------------------------------------------------ PakD_Ddis ------------------------------------------------------------ 19075_Tthe ------------------------------------------------------------ 25909_Tthe ------------------------------------------------------------ PAK1_Spur ------------------------------------------------------------ CC1G_15304_Ccin PGPYSAALAETFSPTLPFSPEEDRMAQERRLRNEASRERLEREEDLNRLSVNTARPNRDS CC1G_00840_Ccin ------------------------------------------------------------ CC1G_02087_Ccin ------------------------------------------------------------ AqueK235_Aque ------------------------------------------------------------ GK081_Glam ------------------------------------------------------------ PAK3_Hsap ------------------------------------------------------------ PAK2_Hsap ------------------------------------------------------------ PAK1_Hsap ------------------------------------------------------------ PAK3_Mmus ------------------------------------------------------------ PAK2_Mmus ------------------------------------------------------------ PAK1_Mmus ------------------------------------------------------------ pak-1_Cele ------------------------------------------------------------ STE20_Scer ------------------------------------------------------------ SKM1_Scer ------------------------------------------------------------ CLA4_Scer ------------------------------------------------------------ Pak3_Dmel ------------------------------------------------------------ Pak_Dmel ------------------------------------------------------------ Y38F1A.10_Cele ------------------------------------------------------------ PakA_Ddis ------------------------------------------------------------ PakB_Ddis ------------------------------------------------------------ PakC_Ddis ------------------------------------------------------------ PakD_Ddis ------------------------------------------------------------ 19075_Tthe ------------------------------------------------------------ 25909_Tthe ------------------------------------------------------------ PAK1_Spur ------------------------------------------------------------ CC1G_15304_Ccin SRSIPPTPIVPPPRQLPNRPAPIDAGHSPSPPNSSFDSEESSASSSQSQDRYPTPTTANS CC1G_00840_Ccin ------------------------------------------------------------ CC1G_02087_Ccin ------------------------------------------------------------ AqueK235_Aque ------------------------------------------------------------ GK081_Glam ------------------------------------------------------------ PAK3_Hsap ------------------------------------------------------------ PAK2_Hsap ------------------------------------------------------------ PAK1_Hsap ------------------------------------------------------------ PAK3_Mmus ------------------------------------------------------------ PAK2_Mmus ------------------------------------------------------------ PAK1_Mmus ------------------------------------------------------------ pak-1_Cele ------------------------------------------------------------ STE20_Scer ------------------------------------------------------------ SKM1_Scer ------------------------------------------------------------ CLA4_Scer ------------------------------------------------------------ Pak3_Dmel ------------------------------------------------------------ Pak_Dmel ------------------------------------------------------------ Y38F1A.10_Cele ------------------------------------------------------------ PakA_Ddis ------------------------------------------------------------ PakB_Ddis ------------------------------------------------------------ PakC_Ddis ------------------------------------------------------------ PakD_Ddis ------------------------------------------------------------ 19075_Tthe ------------------------------------------------------------ 25909_Tthe ------------------------------------------------------------ PAK1_Spur ------------------------------------------------------------ CC1G_15304_Ccin TSSPLRYYLEPSPSPSQASFSPVVARHKEYPNVPPAYDIDEDLDEDDEEGTNLIIPHQII CC1G_00840_Ccin ------------------------------------------------------------ CC1G_02087_Ccin ------------------------------------------------------------ AqueK235_Aque ------------------------------------------------------------ GK081_Glam ------------------------------------------------------------ PAK3_Hsap ------------------------------------------------------------ PAK2_Hsap ------------------------------------------------------------ PAK1_Hsap ------------------------------------------------------------ PAK3_Mmus ------------------------------------------------------------ PAK2_Mmus ------------------------------------------------------------ PAK1_Mmus ------------------------------------------------------------ pak-1_Cele ------------------------------------------------------------ STE20_Scer ------------------------------------------------------------ SKM1_Scer ------------------------------------------------------------ CLA4_Scer ------------------------------------------------------------ Pak3_Dmel ------------------------------------------------------------ Pak_Dmel ------------------------------------------------------------ Y38F1A.10_Cele ------------------------------------------------------------ PakA_Ddis ------------------------------------------------------------ PakB_Ddis ------------------------------------------------------------ PakC_Ddis ------------------------------------------------------------ PakD_Ddis ------------------------------------------------------------ 19075_Tthe ------------------------------------------------------------ 25909_Tthe ------------------------------------------------------------ PAK1_Spur ------------------------------------------------------------ CC1G_15304_Ccin TAPSPQANRPTIVIENVSPGGALSTALPTGTPASPFQRYRGWLSEVVQPLEEYIDEGVDP CC1G_00840_Ccin ------------------------------------------------------------ CC1G_02087_Ccin ------------------------------------------------------------ AqueK235_Aque ------------------------------------------------------------ GK081_Glam ------------------------------------------------------------ PAK3_Hsap ---YTRFEKIGQGASGTVYTALDI---------------------AT-GQ--EVAIKQMN PAK2_Hsap ---YTRYEKIGQGASGTVFTATDV---------------------AL-GQ--EVAIKQIN PAK1_Hsap ---YTRFEKIGQGASGTVYTAMDV---------------------AT-GQ--EVAIKQMN PAK3_Mmus ---YTRFEKIGQGASGTVYTALDI---------------------AT-GQ--EVAIKQMN PAK2_Mmus ---YTRYEKIGQGASGTVFTATDV---------------------AL-GQ--EVAIKQIN PAK1_Mmus ---YTRFEKIGQGASGTVYTAMDV---------------------AT-GQ--EVAIKQMN pak-1_Cele ---YRKVDKIGSGASGSVYTAIEI---------------------ST-EA--EVAIKQMN STE20_Scer ---YANLVKIGQGASGGVYTAYEI---------------------GT-NV--SVAIKQMN SKM1_Scer ---FQLVEKAGQGASGAVYLSKRIKLPQEN-DPRF-LK-SHCHR-VV-GE--RVAIKQIR CLA4_Scer ---FKVIEKAGQGASGSVYLAERTHIPTES-NMIELINNDIDEP-HV-GD--KVAIKQMV Pak3_Dmel ---YKTTQEVGKGASGIVFIAADL---------------------QN-ES--QVAVKTID Pak_Dmel ---YTKMEKIGQGASGTVYTAIES---------------------ST-GM--EVAIKQMN Y38F1A.10_Cele ---YEMKKQIGVGASGTVFVANVA---------------------GS-TD--VVAVKRMA PakA_Ddis ---YYNINKIGEGGAGEVFEAINS---------------------RT-NQ--TIAIKKMK PakB_Ddis --------KIGEGAAGEVFVVTQL---------------------KT-NN--KVAIKKMP PakC_Ddis ---YKNMTKIGEGAAGEVFVATSS---------------------KN-NK--RVAIKKIE PakD_Ddis ---YKVREVVGGGSTGKVYVGENS---------------------IT-GE--KVAIKKMK 19075_Tthe ---YDFLSQIGKGATCKVYRCKNK---------------------QT-GQ--ECAMRVIR 25909_Tthe ---YNFGDKLGKGAMCQVFKATKR---------------------KTKNE--EFAVRVMK PAK1_Spur ---YSKFEKIGQGASGVVYTAIEV---------------------AT-GQ--EVAIKQMN CC1G_15304_Ccin RDHYLDLKEIAEGESGSVFSARLIQKDADKLRLPAHVKAQDADDFAN-NREVLVAIKSVA CC1G_00840_Ccin ---YRNLVKIGQGASGGVYTAYQV---------------------GT-NM--SVAIKQMD CC1G_02087_Ccin ---YSKIKKVGQGASGHVYVAKEL---------------------AT-GK--KVAIKEMD AqueK235_Aque ---YTKMEKIGQGASGVVYTASEI---------------------AT-GN--EVAIKQMN GK081_Glam ---YSNPQEVGHGSSGHVYRATEIK---------------------T-GN--VVAIKSIS . * *: *:: : PAK3_Hsap L----------------QQQPKKELIINEILVMRENKN-PNIVNYLDSYLVG--DELWVV PAK2_Hsap L----------------QKQPKKELIINEILVMKELKN-PNIVNFLDSYLVG--DELFVV PAK1_Hsap L----------------QQQPKKELIINEILVMRENKN-PNIVNYLDSYLVG--DELWVV PAK3_Mmus L----------------QQQPKKELIINEILVMRENKN-PNIVNYLDSYLVG--DELWVV PAK2_Mmus L----------------QKQPKKELIINEILVMKELKN-PNIVNFLDSYLVG--DELFVV PAK1_Mmus L----------------QQQPKKELIINEILVMRENKN-PNIVNYLDSYLVG--DELWVV pak-1_Cele L----------------KDQPKKELIINEILVMRENKH-ANIVNYLDSYLVC--DELWVV STE20_Scer L----------------EKQPKKELIINEILVMKGSKH-PNIVNFIDSYVLK--GDLWVI SKM1_Scer L----------------SEQPKKQLIMNELLVMNDSRQ-ENIVNFLEAYIID-DEELWVI CLA4_Scer L----------------SKQPRKELIVNEILVMKDSRH-KNIVNFLEAYLRT-DDDLWVV Pak3_Dmel M----------------KNQSSKDLILTEIRVLKDFNH-KNLVNFLDAYLLEPEDQLWVV Pak_Dmel L----------------SQQPKKELIINEILVMRENKH-PNVVNYLDSYLVS--EELWVV Y38F1A.10_Cele F----------------KTQPKKEMLLTEIKVMKQYRH-PNLVNYIESYLVD-ADDLWVV PakA_Ddis L----------------KAQNLK-TVINEIGMMKNSNH-ENIVQYIDSYIVA-D-ELWVA PakB_Ddis L----------------NQQNMK-LIVTEIGIMKSCRH-QNIIDYIDSYLVG-D-SLWVA PakC_Ddis I----------------NNDNAK-LLVTEIAIMKTSHH-DNIVNYIDSYIVN-DRELWVA PakD_Ddis V----------------DNNNIK-NIINEISTMKNSKH-KNVIKYVSSHLVI-N-HIWLI 19075_Tthe M----------------LNPDQIEKTKMEILLMNESKN-NNIVQYYKSYIYM--DVIFMA 25909_Tthe L----------------GDEGSMNKIKIEMAIMKICQH-KNIVRYYETFKFM--SCLFMV PAK1_Spur L----------------QQQPKKELIINEILVMRENKH-QNIVNYLDSYLVS--DELWVV CC1G_15304_Ccin IV--------------PSGSPKLKDLQHELGLMKGLHH-ENVIGLDSLYVDFLEDTLWIR CC1G_00840_Ccin L----------------DKQPKKDLIINEILVMRSSRH-PNIVNYIDSFLYK--NDLWVV CC1G_02087_Ccin L----------------SHQPRKELIVNEILVMKESQH-PNIVNFLNSYLVK-NNELWVV AqueK235_Aque L----------------QQQPKKELIINEIIVMKEIKQ-PNIVNFLDSYLVG-ESELWVV GK081_Glam AINFLTDDGKKVRDIKSAEAATLMALKNEVALMYLSKECEYIVKLHKVYFSKAAKEFYMI *: : .. :: . . ::: PAK3_Hsap MEYLAGGSLTDVVTE---------------------TCMDEGQIAAVCRECLQALDFLHS PAK2_Hsap MEYLAGGSLTDVVTE---------------------TCMDEAQIAAVCRECLQALEFLHA PAK1_Hsap MEYLAGGSLTDVVTE---------------------TCMDEGQIAAVCRECLQALEFLHS PAK3_Mmus MEYLAGGSLTDVVTE---------------------TCMDEGQIAAVCRECLQALDFLHS PAK2_Mmus MEYLAGGSLTDVVTE---------------------TCMDEAQIAAVCRECLQALEFLHA PAK1_Mmus MEYLAGGSLTDVVTE---------------------TCMDEGQIAAVCRECLQALEFLHS pak-1_Cele MEYLAGGSLTDVVTE---------------------CQMEDGIIAAVCREVLQALEFLHS STE20_Scer MEYMEGGSLTDVVTH---------------------CILTEGQIGAVCRETLSGLEFLHS SKM1_Scer MEYMEGGCLTDILDAVARSN----T-------GEHSSPLNENQMAYIVKETCQGLKFLHN CLA4_Scer MEFMEGGSLTDIIENSPTND-------------NSHSPLTEPQIAYIVRETCQGLKFLHD Pak3_Dmel MEYMDGGPLTDVVTE---------------------TVMKERQIACVCRETLYAISFLHA Pak_Dmel MEYLPGGSLTDVVTE---------------------TCMDEGQIAAVCREVLQALEFLHA Y38F1A.10_Cele MDYLEGGNLTDVVVK---------------------TELDEGQIAAVLQECLKALHFLHR PakA_Ddis MEFMSGGCLTEVLDQYR------------------DIQLNESQIAFVCQEVLRGLEYIHK PakB_Ddis MEFMGGGCLTEILEQFN------------------SVKLVEAQIAYVCAETLKGLAYIHS PakC_Ddis MEFMGGGCLTDILEAFD------------------NIKMSEIQIAYVVKETLKALQYIHS PakD_Ddis MEYMSYGSLTDLISNCINIQCNGNNQQQQQQQQQQQTYFIESHIAYICQQVLQGMDYIHK 19075_Tthe IEYMNAGSLTELIYGN-------------------FSFLSEQMASYICEQILFGLFFIHR 25909_Tthe IEYMNGGSLTEIIYQN-------------------FKTIPEDIIAYILREIIQGLNFIHL PAK1_Spur MEFLAGGSLTDVVTE---------------------TCMDEGQIASVCRECLQALQFLHQ CC1G_15304_Ccin MELME-RSLADIIGLVD-----------------AGLMLPDRMMARFASDILSGLDYLQR CC1G_00840_Ccin MEYMEGGSLTDVVTA---------------------NLMTEGQIAAVSRETCQGLEHLHR CC1G_02087_Ccin MEYMEGGALTDVIEN---------------------NTLEEDQISSICLETCKGLQHLHS AqueK235_Aque MEYLAGGSLTDVVTE---------------------TCMNEGQIAAVCRECLQALKFLHD GK081_Glam MDYCNANCLTNILSRH-------------------GYIKNERVSCMIIRDILKALNHLHE :: *:::: : . : .: .:: PAK3_Hsap NQVIHRDIKSDNILLGMD----------------GSVKLTDFGFCAQITPEQSKRSTMVG PAK2_Hsap NQVIHRDIKSDNVLLGME----------------GSVKLTDFGFCAQITPEQSKRSTMVG PAK1_Hsap NQVIHRDIKSDNILLGMD----------------GSVKLTDFGFCAQITPEQSKRSTMVG PAK3_Mmus NQVIHRDIKSDNILLGMD----------------GSVKLTDFGFCAQITPEQSKRSTMVG PAK2_Mmus NQVIHRDIKSDNVLLGME----------------GSVKLTDFGFCAQITPEQSKRSTMVG PAK1_Mmus NQVIHRDIKSDNILLGMD----------------GSVKLTDFGFCAQITPEQSKRSTMVG pak-1_Cele RHVIHRDIKSDNILLGMD----------------GSVKLTDFGFCAQLSPEQRKRTTMVG STE20_Scer KGVLHRDIKSDNILLSME----------------GDIKLTDFGFCAQINELNLKRTTMVG SKM1_Scer KKIIHRDIKSDNILLNSQ----------------GLVKITDFGFCVELTEKRSKRATMVG CLA4_Scer KHIIHRDIKSDNVLLDTR----------------ARVKITDFGFCARLTDKRSKRATMVG Pak3_Dmel KGIIHRDIKSDNVLLGMD----------------GSVKVTDFGFCANIEG-DEKRQTMVG Pak_Dmel NQVIHRDIKSDNILLGLD----------------GSVKLTDFGFCAQISPEQSKRTTMVG Y38F1A.10_Cele HSIVHRDIKSDNVLLGMN----------------GEVKLTDMGFCAQIQP-GSKRDTVVG PakA_Ddis FNRIHRDIKSDNILIGAN----------------GEIKLADFGYAAQLTQIRQERNSVVG PakB_Ddis QHRIHRDIKSDNILLGSD----------------GSVKLADFGYAAQLTKSKQKRVTIVG PakC_Ddis LHRIHRDIKSDNILLGSE----------------GSVKIADFGYAAQLTQKQQKRNTVVG PakD_Ddis GHRTHRDIKSDNILLGKD----------------GSVKIADFGFVANLTRKKLQRNSVVG 19075_Tthe TNQIHRDLKSDNILLNQN----------------GDVKIADFGFATQLTREHFSKKSQVG 25909_Tthe QNQAHRDLKSDNILVNKN----------------GEVKVADFGFATQLTQEKQRRKSVVG PAK1_Spur RHVIHRDIKSDNILLGMD----------------GNVKLTDFGFCAQITPEQSKRTTMVG CC1G_15304_Ccin HHIAHRDVRSDNLLINKH----------------GVLKLTDFANAVQVSAQNPMRTEPAG CC1G_00840_Ccin HGVIHRDIKSDNVLLSMV----------------GDIKLTDFGFCAQISEGHAKRTTMVG CC1G_02087_Ccin QSIIHRDIKSDNVLLDAQ----------------GRVKITDFGFCAKLTDQKSKRATMVG AqueK235_Aque NHVIHRDIKSDNILLGMD----------------GQVKLTDFGFCAQITPEQSKRSTMVG GK081_Glam NHRIYRDLKSDNVLLNAELINSLAQDGAITKKKKFSLKLSDFGFAVQLNTKQPTRKSVVG :**::***:*:. :*::*:. ..: : .* PAK3_Hsap TPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQN PAK2_Hsap TPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQN PAK1_Hsap TPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQN PAK3_Mmus TPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQN PAK2_Mmus TPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQN PAK1_Mmus TPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQN pak-1_Cele TPYWMAPEVVTRKQYGPKVDVWSLGIMAIEMVEGEPPYLNENPLRAIYLIATNGKPDFPG STE20_Scer TPYWMAPEVVSRKEYGPKVDIWSLGIMIIEMIEGEPPYLNETPLRALYLIATNGTPKLKE SKM1_Scer TPYWMAPEIVNQKGYDEKVDVWSLGIMLIEMIEGEPPYLNEDPLKALYLIANNGSPKLRH CLA4_Scer TPYWMAPEVVKQREYDEKIDVWSLGIMTIEMLEGEPPYLNEDPLKALYLIATNGTPKLKH Pak3_Dmel TPYWMAPEVVTRKKYGKKVDIWSIGIMAIEMIEGQPPYLYETPLRALYLIAANGRPDIKS Pak_Dmel TPYWMAPEVVTRKQYGPKVDLWSLGIMAIEMVEGEPPYLNENPLKALYLIATNGKPEIKE Y38F1A.10_Cele TPYWMSPEILNKKQYNYKVDIWSLGIMALEMIDGEPPYLRETPLKAIYLIAQNGKPEIKQ PakA_Ddis TPYWMAPELIRGNNYDFKVDVWSLGIMTREMAEGEPPYLEFPPLRALFLLTTQGLPPIRD PakB_Ddis TPYWMAPELIRGQNYDRKVDIWSLGIMAMEMAESEPPYMSFPPLRALFLITTKGIPDLKD PakC_Ddis TPYWMAPELIRGHDYGVKVDIWSLGIMMMEMAEGEPPYMDFPPLRALFLITTKGIPPLKE PakD_Ddis TPYFMAPELIRGNQYNHKVDIWSLGILARELSEGEPPYAKYPPVRALFLLTLEGVPDFKE 19075_Tthe TPAWMAPELILRKDYSQKVDIWSLGVICIEILEGEPPYIRDKPAKAMYYITKK-KPHKLD 25909_Tthe TPAWMAPELILKKEYNEKVDVWSTGIIAIELAMGEPPHLRMPPLKAMYTISSKAPPRL-D PAK1_Spur TPYWMAPEVVTRKQYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPDIHN CC1G_15304_Ccin VLYWQAPEVRSPPYNAMKVDVWSLGATVWEMAETQPPFADTNEFG-------DRWPPLSR CC1G_00840_Ccin TPYWMAPEVVTRKEYGPKVDIWSLGIMAIEMIEGEPPYLNQNPLKALYLIATNGTPTIAN CC1G_02087_Ccin TPYWMAPEVVKQKEYGAKVDIWSLGIMAIEMIENEPPYLDEEPLKALYLIATNGTPTLKK AqueK235_Aque TPYWMAPEVVTRKQYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQN GK081_Glam TPFWMAPELIRGTEYNTKVDCWSLGIVVLELCESLPPHMEMQPLKAVFKIVTSPAPSFKK . : :**: *:* ** * *: **. . * PAK3_Hsap PERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFL PAK2_Hsap PEKLSPIFRDFLNRCLEMDVEKRGSAKELLQHPFL PAK1_Hsap PEKLSAIFRDFLNRCLEMDVEKRGSAKELL----Q PAK3_Mmus PERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFL PAK2_Mmus PEKLSPIFRDFLNRCLEMDVEKRGSAKELLQHPFL PAK1_Mmus PEKLSAIFRDFLNRCLEMDVEKRGSAKELL----Q pak-1_Cele RDSMTLLFKDFVDSALEVQVENRWSASQLLTHPFL STE20_Scer PENLSSSLKKFLDWCLCVEPEDRASATELLHDEYI SKM1_Scer PESVSKQTKQFLDACLQVNVESRASVRKLLTFEFL CLA4_Scer PESLSLEIKRFLSVCLCVDVRYRASTEELLHHGFF Pak3_Dmel WDKLSPNLQDFLDRCLQVEVDRRATADELLSHPFL Pak_Dmel KDKLSSAFQDFLDQCLEVEVDRRASALDLLKHPFL Y38F1A.10_Cele RDRLSSEFNNFLDKCLVVDPDQRADTTELLAHPFL PakA_Ddis AHKWSKEFNDFLALCLEKDTEKRASSSSLLHHPFL PakB_Ddis QNKWSDDFKDFVKKCLDKDVENRPEAKVLLNHPFL PakC_Ddis TTKWSKTFQDFFSKCLDINVANRPDATDLLKHPFM PakD_Ddis PNKWSSDFIEFVNLCLNLDDKRRPDAHYLLRHPFL 19075_Tthe ATKFSQEACDFVSTCLNIDPQERPTAQQLISHPFI 25909_Tthe PANFTQNFCNFVEQCLQKNPDERASFQTLLEHPFL PAK1_Spur PDRLSPVFRNFLAKCLETDVDKRADGEMLLKHPFL CC1G_15304_Ccin PQLVSPAFHEFLRLCSEP-AASRPTAGELLKTPFV CC1G_00840_Ccin PENLSPVFTDYLAKTLEVDAEKRPSATELLQHPFF CC1G_02087_Ccin PEALSKELKSFLAVCLCVDVASRATAIELLDHEFL AqueK235_Aque PENLSRVFRDFLDRCLEMEVDKRGSASELLTHVFL GK081_Glam PSQWTPELNDFLARCLDKDPDSRWSCAQLLEHPWI : :. * *: