CLUSTAL W (1.83) multiple sequence alignment PEK_Hsap FEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPN-------RE-LAREKVMREVKALA PEK_Dmel FELMQCLGRGGFGVVFEAKNKLDENRYAIKRITLPN-------KE-SSRQRVLREARTLA PEK_Mmus FEPIQCMGRGGFGVVFEAKNKVDDCNYAIKRIRLPN-------RE-LAREKVMREVKALA pek-1_Cele FEVKKVIGHGGFGVVFRAQSITDMNEYAVKRIAVAD-------ND-KARNRVLREARALA Y38E10A.8_Cele YDVVDVLGQGSFGIVFQAQRKNDRELRAVKRLDLDS-------AT---LPRAAREVTTIT DDB0219793e_Ddis FCEIEKVGKGGYGSVFKVKNKLDGEYYALKKIPFKN-------TTKTFLEKVLREVKTLA DDB0229432_Ddis FKEISKLGSGGFGSVYLSEYVLDGHKYAIKKVNFSISNNQSPTNASSKIEKVVREVVALA PEK_Spur FEHTECLGKGGFGIVFRAKNKVDENNYAVKRITLPN-------RE-EARDKVLREARTLA AqueK196_Aque FEKLGMLGKGGFGVVYHVLHKVDKGKYAIKMIPT-------------TSGKVKREVHALS AqueK197_Aque ------------------------------------------------------------ AqueK198_Aque ------------------------------------------------------------ AqueK199_Aque -----------------------------------------------xSGKVKREVHALS PEK_d_Smoe ------------------------------------------------------------ PEK_Hsap KLE-HPGIVRYFNA-WLEAPPEKWQEKMD------------------------------- PEK_Dmel SCE-HHNIVRYFHS-WTETPPTGW------------------------------------ PEK_Mmus KLE-HPGIVRYFNA-WLETPPEKWQEEMD------------------------------- pek-1_Cele MFD-HPGIIRYFYA-WEERPPKGFQEKED------------------------------- Y38E10A.8_Cele SIGRHSGYIFFDEVFWKE------------------------------------------ DDB0219793e_Ddis SLN-HRNIVRYHSA-WLETEELLPPSS--SMA--STSLSTSNG-KQIDSDIKNIIYNNHL DDB0229432_Ddis KLD-HINILRYHNA-WLELDPKNNKPRSSSFSSVEGSLGTGNNDND-------------- PEK_Spur ILD-HSGIVRYFNS-WLEEPPLGWQDIQD------------------------------- AqueK196_Aque VLY-HPGIVRYYNS-FIDCAPVGWDDD--------------------------------- AqueK197_Aque ------------------------------------------------------------ AqueK198_Aque ------------------------------------------------------------ AqueK199_Aque VLY-HPGIVRYYNS-FIDCAPVGWDDN--------------------------------- PEK_d_Smoe ------------------------------------------------------------ PEK_Hsap -----------EIWLKDESTD-----WPLSSPSPMDAPSVK-IRRMDPFAT---K----- PEK_Dmel ------------------------------------------------------------ PEK_Mmus -----------EIWLKDESTD-----WPLSSPSPMDAPSVK-IRRMDPFST---K----- pek-1_Cele -----------ENLLGKIKAEKLAKLHEIKKAKKHTSEGKR-VRSADTA----------- Y38E10A.8_Cele ------------------------------------------------------------ DDB0219793e_Ddis LFDGNWGTTSEEASYLNES-D-----NPCN----R--RVNKA-K-----------K---- DDB0229432_Ddis ESDDSFFEDQDEDEDEDEDED-----DVSN-SNFS--DSIKF-KGGFKKSSCSNNS---- PEK_Spur -----------KKFVGESSLGGNDGLTSLDTPAFFNKNSEL-IRNHDQLMQ---QTGGRS AqueK196_Aque -----------------DAMD-----EPSTSFGPSNSLSVQSVRTLSPI----------- AqueK197_Aque ------------------------------------------------------------ AqueK198_Aque ------------------------------------------------------------ AqueK199_Aque ------------------AMD-----EPSTSFGQSNLSSVQSARTLSPV----------- PEK_d_Smoe ------------------------------------------------------------ PEK_Hsap -------------------------------EHIEII-------------APS----PQR PEK_Dmel ------------------------------------------------------------ PEK_Mmus -------------------------------EQIEVI-------------APS----PER pek-1_Cele -------SF--------------------------------------------------- Y38E10A.8_Cele ------------------------------------------------------------ DDB0219793e_Ddis ------------KVSPQKKKNVNNNNNNSKKKALDQSG-------------AG----DDN DDB0229432_Ddis ------------ISSNLKK--KRNDKKYPFKRNL-------------------------- PEK_Spur SMGPSYVPFSKTRESPILKFDLSDDSNVSSEGRVDQKGDNKRAGVESDILFPGAVCEFEE AqueK196_Aque ------------------------------------------------------------ AqueK197_Aque ------------------------------------------------------------ AqueK198_Aque ------------------------------------------------------------ AqueK199_Aque ------------------------------------------------------------ PEK_d_Smoe ------------------------------------------------------------ PEK_Hsap SRSFSVGISCDQTSSSESQFSPL----EF---------------------------S--- PEK_Dmel ------------------------------------------------------------ PEK_Mmus SRSFSVGISCGQTSSSESQFSPL----EF---------------------------S--- pek-1_Cele AESFAMPPVVGNTTDAENSWSTSAKPQEV-----------GAKRT--------TSES--- Y38E10A.8_Cele ------------------------------------------------------------ DDB0219793e_Ddis DDDISSSSSSSSSSSSDDSLYKL----QFPHDEDFKQFNKQTSIRESMINSSRF--KKSY DDB0229432_Ddis SISFSLNDSVTNTNSQEYSISE-----YFEKF---------------------------- PEK_Spur SGSFSIVFQGTEEE-NSQNMSVI----SD---------------------------T--- AqueK196_Aque ----------------------------------------GANHN--------------- AqueK197_Aque ------------------------------------------------------------ AqueK198_Aque ------------------------------------------------------------ AqueK199_Aque ----------------------------------------GASIN--------------- PEK_d_Smoe ------------------------------------------------------------ PEK_Hsap --GMDHEDISESVDAAYN--LQDSCLTDC-DVEDGTMDGNDEG-HS--FELCP------- PEK_Dmel ------------------------------------------------------------ PEK_Mmus --GTDCGDNSDSADAAYN--LQDSCLTDCEDVEDGTVDGNDEG-HS--FELCP------- pek-1_Cele --KLGLHGGSDRTTAELK--EESVAFSES-DEE--------------------------- Y38E10A.8_Cele ------------------------------------------------------------ DDB0219793e_Ddis DDSDDSNDVSSNGVGFFKTPKK--HYTSF-SLDDGSDEESDED-DSQ--GFDDTNRSTMT DDB0229432_Ddis ----NLTNNSESDESEIEESDSDEIYSES-E------SEESESEESESDESEESESD-SD PEK_Spur --GEETPQNLATFDESISNRSTDTSL-------DNTMD------VP--FKHYA------- AqueK196_Aque ------------------------------------------------------------ AqueK197_Aque ------------------------------------------------------------ AqueK198_Aque ------------------------------------------------------------ AqueK199_Aque ------------------------------------------------------------ PEK_d_Smoe ------------------------------------------------------------ PEK_Hsap -------------------SEASPYVRSRERTSSSIVFEDSGCDNASSKEEP-KTNRLHI PEK_Dmel ------------------------------------------------------------ PEK_Mmus -------------------SEASPYTRSREGTSSSIVFEDSGCGNASSKEEP-RGNRLHD pek-1_Cele -------------------------SDTTEDSSSSDESPSSSSG-SSIDDEPKKYNSSSG Y38E10A.8_Cele ------------------------------------------------------------ DDB0219793e_Ddis NIQNDTD------------TESFNHSRHRRSFSSSEGEEETDDD-SLSESDSDYSGVFEN DDB0229432_Ddis NIDFENENIKEMIKALTISKSMIPFVKPIKKKKGKIYNPSSGSG-ASS------------ PEK_Spur -------------------NDAKDIRDLDRSESFQIVFEDSGCTDQPRYSDS-EST---- AqueK196_Aque ---------------------------SSGTESFSIEFRDDSLQKNRSQEK--------- AqueK197_Aque ------------------------------------------------------------ AqueK198_Aque ------------------------------------------------------------ AqueK199_Aque ---------------------------TSGTESSSIEFRDDSSQKNRSQEK--------- PEK_d_Smoe ------------------------------------------------------------ PEK_Hsap GNHCANKLTAFKPTSSKSS-SEA----TLSISPP-------------RPTTLSLDL---- PEK_Dmel ------------------------------------------------------------ PEK_Mmus GNHYVNKLTDLKCSSSRSS-SEAT---TLSTSPT-------------RPTTLSLDF---- pek-1_Cele GIEFVDGSDDVDNEAVKETKKEIAVIEELSIH-N-------------RAMIVETEN---- Y38E10A.8_Cele ------------------------------------------------------------ DDB0219793e_Ddis N-------DDLIPNPSSIP-TSTTP--PISMPPKQYQQQQQQQQQKSQPPSLRSSLTQ-N DDB0229432_Ddis -------------GSGNSS-SIG----------------DSDSSEGNKPKGLTLSTKQLS PEK_Spur -----------QSDTSKSS-KNSS---TPSSAPC---------MEGHWRETSSHHA---- AqueK196_Aque -----------------------G-------IPT---------HTKSTDETLTDDA---- AqueK197_Aque ------------------------------------------------------------ AqueK198_Aque ------------------------------------------------------------ AqueK199_Aque -----------------------G-------IPT---------HTKVTDETLTDDA---- PEK_d_Smoe ------------------------------------------------------------ PEK_Hsap --------------------------TKNTTEK-LQPSSPKVYLYIQMQLCRKENLKDWM PEK_Dmel ---------------------------------------------IQMQLCRKESLRDWL PEK_Mmus --------------------------TKNTVGQ-LQPSSPKVYLYIQMQLCRKENLKDWM pek-1_Cele --------------------------QELEVRE-RNDTGDCAYLYIVMQLCAEKTLEDWI Y38E10A.8_Cele -----------------------------------HKTGSAGHMYICMELCEQNTLKDWI DDB0219793e_Ddis NSLLKP--SINNNNNN---NNN----NNNKNNIVSPKINRITTLFIVMQLYS-QTLSQWL DDB0229432_Ddis NSQLIGINNLNNNNNNRNNNNNNNNRNNDKNSN-SNNLRLKYTVYIQTQYCEGKTLRDLL PEK_Spur ---------------------TDPSQTPTTTSL-AVMKVQKIYLYIQMQLCRKETLKDWL AqueK196_Aque --------------------------TDDTTSY-SSLAGYQKYLFIQMELCQRKTLRDWL AqueK197_Aque ------------------------------------------------------------ AqueK198_Aque ------------------------------------------------------------ AqueK199_Aque --------------------------TDDTTPY-SSLSGYQKYLFIQMELCQRETLRDWL PEK_d_Smoe ------------------------------------------------------------ PEK_Hsap NGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDD----------- PEK_Dmel RDNRS--ETRAAHIGDIFHQIVDAVDYVHLKGLIHRDLKPSNIFFSQDG----------- PEK_Mmus NRRCSLEDREHGVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDD----------- pek-1_Cele RRSKTMESRPLFTMKNWIKQLASGLEYLHNKGFIHRDLKPGNVFFSLDSTH--------- Y38E10A.8_Cele KGNRTARSRPWMLMKDWIKQL---------------AFEARDVFFARDSQF--------- DDB0219793e_Ddis ENRPP-DQVNEEENLNIFKQICIGLRYIHSKGIIHRDLKPGNVFLVREEDHHQQSSFSNI DDB0229432_Ddis ENPDF-KNNSKTTILSLFKQIITGVNYIHSMGMIHRDLKPANLFLS-SG----------- PEK_Spur STNTL--SRDRNKVLHIFHQILEAVNYIHGCGMIHRDLKPSNIFFSVDG----------- AqueK196_Aque SINVH--NRYRIKVFNFFVQILDAVIYMHDKDYIHRDLKPSNILFAMDD----------- AqueK197_Aque -------------------xILDAVIYMHDKDYIHCDLKPSNILFAMND----------- AqueK198_Aque ---------------------------------------PSNILFAMND----------- AqueK199_Aque SKNVR--NRYRIKVFNYFEQILDAVIYMHDKDYIHRDLKPSNILFAMND----------- PEK_d_Smoe ------------------------------------------------------------ PEK_Hsap -------------VVKVGDFGLVTAM---------------------------------- PEK_Dmel -------------QIKIGDFGLVTDM---------------------------------- PEK_Mmus -------------VVKVGDFGLVTAM---------------------------------- pek-1_Cele ----------GHQILKIGDLGLATKT---------------------------------- Y38E10A.8_Cele ------------KKLKIGDFGLTTRA---------------------------------- DDB0219793e_Ddis SSSFEENSDGGGLLVSLGDFGLAVQHTIVSSTPSPTPTSTPSLTPVNSHISPIDQIININ DDB0229432_Ddis -------------VIKIGDFGLVKDI---------------------------------- PEK_Spur -------------KIKVGDFGLVTAI---------------------------------- AqueK196_Aque -------------SIKVGDFGLVKQN---------------------------------- AqueK197_Aque -------------SIKVGDFGLVKQN---------------------------------- AqueK198_Aque -------------SIKVGDFGLVKQN---------------------------------- AqueK199_Aque -------------SIKVGDFGLVKQN---------------------------------- PEK_d_Smoe ------------------------------------------------------------ PEK_Hsap -----------------------------DQDEEE-QTV--LTPMPA------------- PEK_Dmel -----------------------------ADIPNLVAKCGDQSGLPS------------- PEK_Mmus -----------------------------DQDEEE-QTV--LTPMPA------------- pek-1_Cele ------------------------------DGAPKITVR-Q--DSDS------------- Y38E10A.8_Cele -----------------------------IEGLKDWKQRTQ--SQEA------------- DDB0219793e_Ddis QQLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQXXXXXXX-XXXTVSLSS---------- DDB0229432_Ddis ---------------------------------TATTPST-TPLTNNTPSTTPIDTTPTS PEK_Spur -----------------------------DTSME-GAEDSV--DGAA------------- AqueK196_Aque -----------------------------VAT-KHSAP--Q---SDV------------- AqueK197_Aque -----------------------------AAT-KHSAP--Q---TDV------------- AqueK198_Aque -----------------------------AAI-KHSAP--Q---TDV------------- AqueK199_Aque -----------------------------AAT-KHSAP--Q---TDV------------- PEK_d_Smoe ------------------------------------------------------------ PEK_Hsap ------------------------------------------------------------ PEK_Dmel ------------------------------------------------------------ PEK_Mmus ------------------------------------------------------------ pek-1_Cele ------------------------------------------------------------ Y38E10A.8_Cele ------------------------------------------------------------ DDB0219793e_Ddis -----------------------S--SSSSILTPPISSMQQQHQQQPPPLQTTSPTGQSQ DDB0229432_Ddis SANTIPISTPPTSTITPTISVSPSKPLSS-------------------SLSSTAATTHLN PEK_Spur ------------------------------------------------------------ AqueK196_Aque ------------------------------------------------------------ AqueK197_Aque ------------------------------------------------------------ AqueK198_Aque ------------------------------------------------------------ AqueK199_Aque ------------------------------------------------------------ PEK_d_Smoe ------------------------------------------------------------ PEK_Hsap ------------------------------YARHTGQVGTKLYMSPEQIHG--------- PEK_Dmel ------------------------------CARHTQQVGTHLYMSPEQLLG--------- PEK_Mmus ------------------------------YATHTGQVGTKLYMSPEQIHG--------- pek-1_Cele ------------------------------SAKHTKNVGTRSYMSPEQLKH--------- Y38E10A.8_Cele ------------------------------GQNHTAGAGTPSYMAPEQIR---------- DDB0219793e_Ddis QSIPSTPSSLSSSSTTPSVSTGTSLSRSLEHCKHTSAVGTLTYSSPEQKKG--------- DDB0229432_Ddis SSLGCTISSSSSTTTATATTSTTPFMFYNSISVNTVGVGTLTYASPEQLSNKGVFGGGGY PEK_Spur ------------------------------GHLHTGRVGTQLYMCPEQVSG--------- AqueK196_Aque ------------------------------QGSHTSEIGTSFYVSPEQKAG--------- AqueK197_Aque ------------------------------QGSHTSEIGTLFYVSPEQEAG--------- AqueK198_Aque ------------------------------QGSHTSEIGTSFYVSPEQEAG--------- AqueK199_Aque ------------------------------QGSHTSEIGTSFYVSPEQEAG--------- PEK_d_Smoe -----------------------------------------WYTSPEELAG--------- * .**: PEK_Hsap --NSYSHKVDIFSLGLILFELLY-PFSTQMERVRTLTDVRN-LKFPPLFTQKYPCEYVMV PEK_Dmel --QHYDYKVDIYSLGLIFFELHV-YFSTEMERIKTLRSLRD-GQYPKDFAVNYPQQYDLL PEK_Mmus --NNYSHKVDIFSLGLILFELLY-PFSTQMERVRILTDVRN-LKFPLLFTQKYPQEHMMV pek-1_Cele --QQYTEKVDIFALGLVATELII-SFSTASERIHTFADFQK-GDIPAIL-DNVPESRDFL Y38E10A.8_Cele --NQYNEKVDIFALGLIAAELII--INTPSDEMGTNDIIRS-GQWPIAW-QDYPDAIEFL DDB0219793e_Ddis ---LYNEKTDIYSLGIILFELYF-PISTRMEKARVLTDLRN-GVLPKSFLQKYPKVSELI DDB0229432_Ddis TNTWYTNKTDIYSCGIILFEMIVGGFETQFERTTHIKNLKN-GILPSWFTSKHPEESNLI PEK_Spur --QNYDHKVDIFSLGLIFFELFH-PFSTQMERITVMCKAKR-QDFPKRFTKELPLEAKFA AqueK196_Aque --HRYNERADVYSLGIILFE---------------------------------------- AqueK197_Aque --HQYNERADVYSLGIILFELYF-PFSTRMERVKVLEDIKSNRRLPKEFKENLHNEAKLV AqueK198_Aque --HRYNERADVYSLGIILFELYF-PFSTRMERVKVLEDVKNNRRLPKEFKENLHNEAKLV AqueK199_Aque --HRYNERADVYSLGIILFELYF-PFSTVMERAKVLGDVKSNRRLPKEFKENLHNEAKLV PEK_d_Smoe --GASSFASDVYSLGVLFFELFC-VFSSNMEWSRAMSDLRH-RILPPRLLSESPKEAALC *::: *:: * PEK_Hsap QDMLSPSPMERPEAINIIENAVF PEK_Dmel QQMLSAQPEQRPQTKQLK--SQL PEK_Mmus QDMLSPSPTERPEATDIIENAIF pek-1_Cele LQLTSLEPSERPT---------A Y38E10A.8_Cele SQLTHMNPTMRPSAVEVSMHPFV DDB0219793e_Ddis LLMMKTNPDERPSASDILKSDLF DDB0229432_Ddis LRMIDINPDNRPTSDQIL-SELL PEK_Spur KWLLSHDPDLRPDTDEISESDSD AqueK196_Aque ----------------------L AqueK197_Aque ELMLKP-ISDRPSSSEIKEIDAF AqueK198_Aque ELMLKP-ISDRPSSSEIKE---I AqueK199_Aque ELMLKP-ISDRPSSSEIKEI-DA PEK_d_Smoe LWLLHPEPQSRPKAREIFQCELF