CLUSTAL W (1.83) multiple sequence alignment PLK3_Hsap YLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHRH PLK2_Hsap YCRGKVLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDKEIELHRILHHKH PLK2_Spur ---------GGFARCYELTHLDTHYVYAGKIVPKERISKPSQREKMEREIAVHAQLRHPH PLK5_Mmus YRRGKLIGKGAFSRCYKLTDMSTSAVFALKVVPRGGAGRLRLRGKVEREIALHSRLRHRN PLK2_Mmus YCRGKVLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDKEIELHRLLHHKH PLK3_Mmus YTKGRLLGKGGFARCYEATDTESGIAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHRH *.*::**: *. . .:* *::*: .: * *: .** :* *:* : PLK3_Hsap IVRFSHHFEDADNIYIFLELCSR----KSLAHIWKARHTLLEPEVRYYLRQILSGLKYLH PLK2_Hsap VVQFYHYFEDKENIYILLEYCSR----RSMAHILKARKVLTEPEVRYYLRQIVSGLKYLH PLK2_Spur IVGFHKHFQDAENIYILLELCRH----KSLLHMLKLRKHLTEPEVRYFMLQIIEGVRYLH PLK5_Mmus IVAFHAHFADRDHVYMVLEYCSRQVPLQSLAHVLKVRRTLTEPEVRYYLRGLVSGLRYLH PLK2_Mmus VVQFYHYFEDKENIYILLEYCSR----RSMAHILKARKVLTEPEVRYYLRQIVSGLKYLH PLK3_Mmus IVRFSHHFEDADNIYIFLELCSR----KSLAHIWKARHTLLEPEVRYYLRQILSGLKYLH :* * :* * :::*:.** * : :*: *: * *: * ******:: ::.*::*** PLK3_Hsap QRGILHRDLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGH PLK2_Hsap EQEILHRDLKLGNFFINEAMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGH PLK2_Spur SHCVIHRDLKLGNMFLTDTMGVKIGDFGLAAKLEFEGDRKRTMCGTPNYIAPEVLGKIGH PLK5_Mmus QQRIVHRDLKPSNFFLNKNMEVKIGDLGLAARVGPAGRCHRVLCGTPNFQAPEVVSRNGH PLK2_Mmus EQEILHRDLKLGNFFINEAMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGH PLK3_Mmus QRGILHRDLKLGNFFITDNMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGH .: ::***** .*:*:.. * :*:**:****:: ::.:*****: :***: : ** PLK3_Hsap GPEADVWSLGCVMYTLLCGSPPFETADLKETYRCIKQVHYTLPASLSLPARQLLAAILRA PLK2_Hsap GCESDIWALGCVMYTMLLGRPPFETTNLKETYRCIREARYTMPSSLLAPAKHLIASMLSK PLK2_Spur SFEADVWALGCIMYTMLVGRPPFETSSLKETYARIKHNKYHFPETLSPVAKEIISDLLSS PLK5_Mmus SCKSDIWALGCIMYTVLTGTPPFAAAPLSEMYQNIRDGHYLEPTHLSPSARSLIARLLAP PLK2_Mmus GCESDIWALGCVMYTMLLGRPPFETTNLKETYRCIREARYTMPSSLLAPAKHLIASMLSK PLK3_Mmus GPEADVWSLGCVMYTLLCGSPPFETADLKETYRCIKQVHYTLPASLSLPARQLLAAILRA . ::*:*:***:***:* * *** :: *.* * *:. :* * * *: ::: :* PLK3_Hsap SPRDRPSIDQILRHDFF PLK2_Hsap NPEDRPSLDDIIRHDFF PLK2_Spur DPEERPPLEVVIDHEFF PLK5_Mmus DPAERPSLDHLLQDDFF PLK2_Mmus NPEDRPSLDDIIRHDFF PLK3_Mmus SPRDRPSIEQILRHDFF .* :**.:: :: .:**