CLUSTAL W (1.83) multiple sequence alignment PRP4_Hsap ------------------------------------------------------------ PRP4_Mmus ------------------------------------------------------------ F22D6.5_Cele ------------------------------------------------------------ Prp4_Ddis ------------------------------------------------------------ 15575_Tthe KQ---------KKKEDGELSGEEDEYKSPKQKKSDKDDRKKSKRSSRSHSS-RR------ PRP4_Spur K---------HKHK------SKKSHHKHKHH-KENKDGHRRHKHKHKKHKS-KK------ CG7028_Dmel ------------------------------------------------------------ CC1G_04865_Ccin ------------------------------------------------------------ AqueK115_Aque ------------------------------------------------------------ AqueK116_Aque ------------------------------------------------------------ PRP4_e_Smoe ------------------------------------------------------------ PRP4_d_Smoe ------------------------------------------------------------ PRP4_b_Smoe ------------------------------------------------------------ PRP4_a_Smoe GRVDDAKDKSRKRK------SVEDEQPSSKR-REDDDGKRKHKHRKHKHRSSHRKHISKE PRP4_c_Smoe ------------------------------------------------------------ PRP4_Hsap ------------------------------------------------------------ PRP4_Mmus ------------------------------------------------------------ F22D6.5_Cele ------------------------------------------------------------ Prp4_Ddis ------------------------------------------------------------ 15575_Tthe TNDKISDSTK-------------------------------------------------- PRP4_Spur DEEPP---------------------VATPAADESESDIELEDTIPLPKFEPKIPPPPPP CG7028_Dmel ------------------------------------------------------------ CC1G_04865_Ccin ------------------------------------------------------------ AqueK115_Aque ------------------------------------------------------------ AqueK116_Aque ------------------------------------------------------------ PRP4_e_Smoe ------------------------------------------------------------ PRP4_d_Smoe ------------------------------------------------------------ PRP4_b_Smoe ------------------------------------------------------------ PRP4_a_Smoe VDLDVVPAAMACEAEDGEILEPTEDGI--------------------------------- PRP4_c_Smoe ------------------------------------------------------------ PRP4_Hsap ------------------------------------------------------------ PRP4_Mmus ------------------------------------------------------------ F22D6.5_Cele ------------------------------------------------------------ Prp4_Ddis ------------------------------------------------------------ 15575_Tthe --------------------------------------------------SNKKDKD--- PRP4_Spur PNSRRESGRKERGRGGDDTLAALEKQKELLQAQLLATAEDEHSGMNLIAQGYQSDEEEGE CG7028_Dmel ------------------------------------------------------------ CC1G_04865_Ccin ------------------------------------------------------------ AqueK115_Aque ------------------------------------------------------------ AqueK116_Aque ------------------------------------------------------------ PRP4_e_Smoe ------------------------------------------------------------ PRP4_d_Smoe ------------------------------------------------------------ PRP4_b_Smoe ------------------------------------------------------------ PRP4_a_Smoe ---------------------------------------------VLKE----------- PRP4_c_Smoe ------------------------------------------------------------ PRP4_Hsap ------------------------------------------------------------ PRP4_Mmus ------------------------------------------------------------ F22D6.5_Cele ------------------------------------------------------------ Prp4_Ddis ------------------------------------------------------------ 15575_Tthe ----------------HKDSSRRRSKSRSKDRKDQQKRKYS---------RSRSRSYPND PRP4_Spur DDESALKQSLSKWIRPESSSSKPSSKSELKDSERSEKRKREREDETSQKKQHRSKSPATE CG7028_Dmel ------------------------------------------------------------ CC1G_04865_Ccin ------------------------------------------------------------ AqueK115_Aque ------------------------------------------------------------ AqueK116_Aque ------------------------------------------------------------ PRP4_e_Smoe ------------------------------------------------------------ PRP4_d_Smoe ------------------------------------------------------------ PRP4_b_Smoe ------------------------------------------------------------ PRP4_a_Smoe ----------------EGNGSSESEKDV----------EQEIE----------------- PRP4_c_Smoe ------------------------------------------------------------ PRP4_Hsap ------------------------------------------------------------ PRP4_Mmus ------------------------------------------------------------ F22D6.5_Cele ------------------------------------------------------------ Prp4_Ddis ------------------------------------------------------------ 15575_Tthe RNGTKQRHLDNLYQRTQIKNGKCNQIYGSQKRNTKFSNDKFLFSNSKNLSEAFYIDSYFY PRP4_Spur RSSGS----------SRVDNGDAKSSQSRTNRDSHIASDRKHSKDSDSRRDSRKSSPSAT CG7028_Dmel ------------------------------------------------------------ CC1G_04865_Ccin ------------------------------------------------------------ AqueK115_Aque ------------------------------------------------------------ AqueK116_Aque ------------------------------------------------------------ PRP4_e_Smoe ------------------------------------------------------------ PRP4_d_Smoe ------------------------------------------------------------ PRP4_b_Smoe ------------------------------------------------------------ PRP4_a_Smoe -------------------------------------------------------APKSE PRP4_c_Smoe ------------------------------------------------------------ PRP4_Hsap ------------------------------------------------------------ PRP4_Mmus ------------------------------------------------------------ F22D6.5_Cele ------------------------------------------------------------ Prp4_Ddis ------------------------------------------------------------ 15575_Tthe SLNSSKKDKDRDNAKEKDRKR------SKSPTKDKDRKNDRK-RSKSPRSSNNGK----- PRP4_Spur KSEQRESRDSREPRDSR--KSSGRDGRASPKRELKSGEKSRRESSRDSKPIRSRSPKKER CG7028_Dmel ------------------------------------------------------------ CC1G_04865_Ccin ------------------------------------------------------------ AqueK115_Aque ------------------------------------------------------------ AqueK116_Aque ------------------------------------------------------------ PRP4_e_Smoe ------------------------------------------------------------ PRP4_d_Smoe ------------------------------------------------------------ PRP4_b_Smoe ------------------------------------------------------------ PRP4_a_Smoe RGSPRRSRDGSPPRDNVDRKH------SSPDRRHRGSSVDRKRRSRSKESVRENA----- PRP4_c_Smoe ------------------------------------------------------------ PRP4_Hsap ------------------------------------------------------------ PRP4_Mmus ------------------------------------------------------------ F22D6.5_Cele ------------------------------------------------------------ Prp4_Ddis ------------------------------------------------------------ 15575_Tthe ---------------------------------------------------------RKS PRP4_Spur VFTEPARSRPSPPRRSPPPRRPPSPPARRPDQPLGRRGRSPIERRGRSPLERRIRSSRSP CG7028_Dmel ------------------------------------------------------------ CC1G_04865_Ccin ------------------------------------------------------------ AqueK115_Aque ------------------------------------------------------------ AqueK116_Aque ------------------------------------------------------------ PRP4_e_Smoe ------------------------------------------------------------ PRP4_d_Smoe ------------------------------------------------------------ PRP4_b_Smoe ------------------------------------------------------------ PRP4_a_Smoe ---------------------------------------------------------RHH PRP4_c_Smoe ------------------------------------------------------------ PRP4_Hsap ------------------------------------------------------------ PRP4_Mmus ------------------------------------------------------------ F22D6.5_Cele ------------------------------------------------------------ Prp4_Ddis ------------------------------------------------------------ 15575_Tthe SRSKSPKREDSRRDKDSKSGYRDNEKKSNYGSNRDRESRRSEEN-----NTRESKQLTLE PRP4_Spur AVVDRFDRRRGASPPRRFGDMSRNRRRWSRSPDRRGR-R-GRWGRSRSKS---------- CG7028_Dmel ------------------------------------------------------------ CC1G_04865_Ccin ------------------------------------------------------------ AqueK115_Aque ------------------------------------------------------------ AqueK116_Aque ------------------------------------------------------------ PRP4_e_Smoe ------------------------------------------------------------ PRP4_d_Smoe ------------------------------------------------------------ PRP4_b_Smoe ------------------------------------------------------------ PRP4_a_Smoe SRVASPDRKRRRSRSRDRGDE-R-SRRHAYSPDRRRRSR-SREHDEREKY---------- PRP4_c_Smoe ------------------------------------------------------------ PRP4_Hsap ------------------------------------------------------------ PRP4_Mmus ------------------------------------------------------------ F22D6.5_Cele ------------------------------------------------------------ Prp4_Ddis ------------------------------------------------------------ 15575_Tthe EEEERNDRYYNDFDDSDSDYYQRVNDRKYKSSRRSKS------------RSKNRDRKKSK PRP4_Spur ----------------------------------PRDKFKGSLSEGLSLKQESSDDEIPD CG7028_Dmel ------------------------------------------------------------ CC1G_04865_Ccin ------------------------------------------------------------ AqueK115_Aque ------------------------------------------------------------ AqueK116_Aque ------------------------------------------------------------ PRP4_e_Smoe ------------------------------------------------------------ PRP4_d_Smoe ------------------------------------------------------------ PRP4_b_Smoe ------------------------------------------------------------ PRP4_a_Smoe ----------------------------------PRK------------RAESRDRHIKD PRP4_c_Smoe ------------------------------------------------------------ PRP4_Hsap ------------------------------------------------------------ PRP4_Mmus ------------------------------------------------------------ F22D6.5_Cele ------------------------------------------------------------ Prp4_Ddis ------------------------------------------------------------ 15575_Tthe SKGRKDD-KNKDKDKER---SKNSGNGDNSKSSKDKKEEEAKKAQQPETIDDDE------ PRP4_Spur VDLDEEEDEEAVIERRRR------------------------------------------ CG7028_Dmel ------------------------------------------------------------ CC1G_04865_Ccin ------------------------------------------------------------ AqueK115_Aque ------------------------------------------------------------ AqueK116_Aque ------------------------------------------------------------ PRP4_e_Smoe ------------------------------------------------------------ PRP4_d_Smoe ------------------------------------------------------------ PRP4_b_Smoe ------------------------------------------------------------ PRP4_a_Smoe DRGARDDERHYNRDRNRRDREELSE---------------KQETTQSETIEREEENQDEY PRP4_c_Smoe ------------------------------------------------------------ PRP4_Hsap ------------------------------------------------------------ PRP4_Mmus ------------------------------------------------------------ F22D6.5_Cele ------------------------------------------------------------ Prp4_Ddis ------------------------------------------------------------ 15575_Tthe ---------DLNMEIEDSDDERERKKQEFLNMIKVQGM---------------------- PRP4_Spur ------------------------ERQQLMQKYKVAPAESATSSPAQGPSEPSSTPQSPQ CG7028_Dmel ------------------------------------------------------------ CC1G_04865_Ccin ------------------------------------------------------------ AqueK115_Aque ------------------------------------------------------------ AqueK116_Aque ------------------------------------------------------------ PRP4_e_Smoe ------------------------------------------------------------ PRP4_d_Smoe ------------------------------------------------------------ PRP4_b_Smoe ------------------------------------------------------------ PRP4_a_Smoe LERVAHQLAEQEEDIEKVKEESRKRRQAI------------------------------- PRP4_c_Smoe ------------------------------------------------------------ PRP4_Hsap ------------------------------------------------------------ PRP4_Mmus ------------------------------------------------------------ F22D6.5_Cele ------------------------------------------------------------ Prp4_Ddis ------------------------------------------------------------ 15575_Tthe ------------------------------------------------------------ PRP4_Spur ASEQGGSTAQSQDTDDEDDDEEEEEEDEEEDDSEKSSSSDSDDDSSEVESKASSDDDDDD CG7028_Dmel ------------------------------------------------------------ CC1G_04865_Ccin ------------------------------------------------------------ AqueK115_Aque ------------------------------------------------------------ AqueK116_Aque ------------------------------------------------------------ PRP4_e_Smoe ------------------------------------------------------------ PRP4_d_Smoe ------------------------------------------------------------ PRP4_b_Smoe ------------------------------------------------------------ PRP4_a_Smoe ------------------------------------------------------------ PRP4_c_Smoe ------------------------------------------------------------ PRP4_Hsap ------------------------------------------------------------ PRP4_Mmus ------------------------------------------------------------ F22D6.5_Cele ------------------------------------------------------------ Prp4_Ddis ------------------------------------------------------------ 15575_Tthe --------------------------------------QMQKQEASQTFSKENNQNNQTQ PRP4_Spur EEDDEGDAARIEEEERLREEEEEAEQEKRREMERKRLKE--------------------- CG7028_Dmel ------------------------------------------------------------ CC1G_04865_Ccin ------------------------------------------------------------ AqueK115_Aque ------------------------------------------------------------ AqueK116_Aque ------------------------------------------------------------ PRP4_e_Smoe ------------------------------------------------------------ PRP4_d_Smoe ------------------------------------------------------------ PRP4_b_Smoe ------------------------------------------------------------ PRP4_a_Smoe -------------------------------LEKHKMQQ--------------------- PRP4_c_Smoe ------------------------------------------------------------ PRP4_Hsap ------------------------------------------------------------ PRP4_Mmus ------------------------------------------------------------ F22D6.5_Cele ------------------------------------------------------------ Prp4_Ddis ------------------------------------------------------------ 15575_Tthe NKNDQDVVDDKLKVKDSENLENQNFADENSEEQLFDDTGLNPNDVLDDDDVNIANTINDD PRP4_Spur ------------------------------------------------------------ CG7028_Dmel ------------------------------------------------------------ CC1G_04865_Ccin ------------------------------------------------------------ AqueK115_Aque ------------------------------------------------------------ AqueK116_Aque ------------------------------------------------------------ PRP4_e_Smoe ------------------------------------------------------------ PRP4_d_Smoe ------------------------------------------------------------ PRP4_b_Smoe ------------------------------------------------------------ PRP4_a_Smoe ------------------------------------------------------------ PRP4_c_Smoe ------------------------------------------------------------ PRP4_Hsap ------------------------------------------------------------ PRP4_Mmus ------------------------------------------------------------ F22D6.5_Cele ------------------------------------------------------------ Prp4_Ddis ------------------------------------------------------------ 15575_Tthe YKEEVDESHSLTHRHSIDKAQLDHLKFLEDMRNQEIKGGIPDMPEQPILKQKRKSINSEK PRP4_Spur ------------------------------------------------------------ CG7028_Dmel ------------------------------------------------------------ CC1G_04865_Ccin ------------------------------------------------------------ AqueK115_Aque ------------------------------------------------------------ AqueK116_Aque ------------------------------------------------------------ PRP4_e_Smoe ------------------------------------------------------------ PRP4_d_Smoe ------------------------------------------------------------ PRP4_b_Smoe ------------------------------------------------------------ PRP4_a_Smoe ------------------------------------------------------------ PRP4_c_Smoe ------------------------------------------------------------ PRP4_Hsap ------------------------------------------------------------ PRP4_Mmus ------------------------------------------------------------ F22D6.5_Cele ------------------------------------------------------------ Prp4_Ddis ------------------------------------------------------------ 15575_Tthe LEGKFSNNDQLD-----EENKLHK------------------------------------ PRP4_Spur ---AFPQSDSED-----EESAANSKKGEGSLDKN----------------------LSDI CG7028_Dmel ------------------------------------------------------------ CC1G_04865_Ccin ------------------------------------------------------------ AqueK115_Aque ------------------------------------------------------------ AqueK116_Aque ------------------------------------------------------------ PRP4_e_Smoe ------------------------------------------------------------ PRP4_d_Smoe ------------------------------------------------------------ PRP4_b_Smoe ------------------------------------------------------------ PRP4_a_Smoe ---SQPEEPAETMKVSKPLTAAEPDSGEGIIDPSTPLSLGKSALPNGTILKRNAGGLGEG PRP4_c_Smoe ------------------------------------------------------------ PRP4_Hsap ------------------------------------------------------------ PRP4_Mmus ------------------------------------------------------------ F22D6.5_Cele ------------------------------------------------------------ Prp4_Ddis ------------------------------------------------------------ 15575_Tthe -----LDDQEDSEEETDMF------GDDIDKIINKSNDG--KLQI-VKGANAECDDEQNY PRP4_Spur VKPKSDKEQAMANNGLDMFSEVDMFKMSP-----STREGIGQMGPENPSLTDNWDDEEGY CG7028_Dmel ------------------------------------------------------------ CC1G_04865_Ccin ------------------------------------------------------------ AqueK115_Aque ------------------------------------------------------------ AqueK116_Aque ------------------------------------------------------------ PRP4_e_Smoe ------------------------------------------------------------ PRP4_d_Smoe ------------------------------------------------------------ PRP4_b_Smoe ------------------------------------------------------------ PRP4_a_Smoe SPPKSEK-------PADMFC--DIFGESPAEIRKAGTRD--TLAIDTSGLTDNWDDADGY PRP4_c_Smoe ------------------------------------------------------------ PRP4_Hsap ------------YNVYGYTGQGVFSNVVRARDNA--------------RANQEVAVKIIR PRP4_Mmus ------------YNVYGYTGQGVFSNVVRARDNA--------------RANQEVAVKIIR F22D6.5_Cele ------------YRVVGFTGAGVFGNVCRCNDQT--------------KG-NTVAVKIIR Prp4_Ddis ------------YQIFSPIGSGVFSTVVSAKETKT---------------NEDVVIKIIR 15575_Tthe FKILIGEVLNGKYRVIQKCGKGVFANVCKAEQLDN---------------GKMVAIKILR PRP4_Spur YRVRIGESLDKRYAVYGYTGQGVFSNVVRARDTA--------------RGKLDVAIKIIR CG7028_Dmel ------------YLVNGYTGQGVFSNVVRGRDQA--------------RGQANVAIKIIR CC1G_04865_Ccin ------------YQVFSSLGQGMFANVVRARVLKDENGKDLAVDGVAPESLREVAIKIIR AqueK115_Aque ------------YMVYGYTGQGVFSNVVRARDTS--------------RSSQEVAIKIIR AqueK116_Aque ------------YMVYGYTGHGVFSNVVRARDTS--------------RSSQEVAIKIIR PRP4_e_Smoe ------------YQVKASIGSGMFSTVFLAKSLFP-------------ECEQEVAIKIPR PRP4_d_Smoe ------------YQVKASIGSGMFSTVFLAKSLLP-------------ECQQEVAIKIPR PRP4_b_Smoe ------------YEIASSHGRGVFSTVVRARDTKAGRG-----------EPEEVAIKIIR PRP4_a_Smoe YTYRVGEVLDNRYEIASSHGRGVFSTVVRARDTKAGRG-----------EPEEVAIKIIR PRP4_c_Smoe ------------------------------------------------------------ PRP4_Hsap NNELMQKTGLKELEFLKKLNDA--DPDDK-FHCLRLFRHFYHKQHLCLVFEPLSMNLREV PRP4_Mmus NNELMQKTGLKELEFLKKLNDA--DPDDK-FHCLRLFRHFYHKQHLCLVFEPLSMNLREV F22D6.5_Cele NNEVMYKTGLRELEVLRKLNEA--DKEDK-YHCLRLFRTFKHHNHLCLVFENLSMNLREL Prp4_Ddis NRPSMHRSGLKEIEILQKISNTPTSSNQK-SHCIQMKDHFNYRNHLCIVFEPMSMSLHQL 15575_Tthe SNEIMRDSGEREKEIIQKLNLN--DKNDR-KHIVRLKNVFEHQKHMCLVFECFAMNLRDA PRP4_Spur NNDLMQKTGMKELEYLKRLNDQ--DREDK-FHCVRLFRSFSYRQHLCLVFEPLSMNLREV CG7028_Dmel NNEIMHKTGLRELEILKKLNDA--DPEDR-FHCLRLYRHFFHKQHLCMVFEPLAMNLREV CC1G_04865_Ccin SQESMYKAGLKEAQILQKLRAL--DPEDK-KHIVKLERTFEHRGHLCLVFENLSMNLREV AqueK115_Aque NNEMMHKTGMAELEILKKLNAT--DPDDK-FHCIRLFSNFFHKNHLCLVFESMSMNIREV AqueK116_Aque NNEMMHKTGMAELEILKKLNAT--DPDDK-FHCIRLFSNFFHKNHLCLVFESMSMNIREV PRP4_e_Smoe KNDLMLRSAKSELQILKKVAEP--EATNKDNHCVKLLDSFVYREHLCLVMESLDLNLRQI PRP4_d_Smoe KNDLMLRSAKSELQILKKVAEP--EATNKDNHCVKLLDSFVYREHLCLVMEFLDLNLRQI PRP4_b_Smoe SNETMFKAGQMELIILNKLAGA--DLENK-RHCVRLLSSFEYRNHLCLVFESLHMNLREI PRP4_a_Smoe SNETMFKAGQMELIILNKLAGA--DLENK-RHCVRLLSSFEYRNHLCLVFESLHMNLREI PRP4_c_Smoe -------------------------------------------EHLCLVMESLDLNLRQI *:*:*:* : :.::: PRP4_Hsap LKKYGKDVGLHIKAVRSYSQQLFLALKLLKRCNILHADIKPDNILVNESKTILKLCDFGS PRP4_Mmus LKKYGKDVGLHIKAVRSYSQQLFLALKLLKRCNILHADIKPDNILVNESKTILKLCDFGS F22D6.5_Cele LKKYGQKDGLHLKAVRSYAQQLLLALRLLKKLEFVHADIKPDNILVNESKLTLKLCDFGS Prp4_Ddis IKKYGKDIGLSLNAVRVYAKQLFLALKHIKNSKILHADIKPDNIVVNEAKNTIKIVDFGS 15575_Tthe LKEYGKGKGFSLDVVRSYAYQIFVALTHLKKNNYIHADLKPDNLLISEDTKTLKMCDFGT PRP4_Spur LKRYGKDVGLHIKAVRSYTQQLFLALKLLKRCNILHADIKPDNILVNESKSVLKLCDFGS CG7028_Dmel LKKYGKNVGLHIKAVRSYTQQLFLALKLLKKTGILHADIKPDNILVNENNLILKLCDFGS CC1G_04865_Ccin VKRFGKDVGLNIRAVRAYAHQLFLALSLLRKANIMHADIKPDNILVNEQKNLIKLCDLGS AqueK115_Aque LRKYGKNIGLHIKAVRSYSQQLLLALKLMKRCTILHADIKPDNILVNESKLMLKLCDFGS AqueK116_Aque LRKYGKNIGLHIKAVRSYSQQLLLALKLMKRCTILHADIKPDNILVNESKLMLKLCDFGS PRP4_e_Smoe TNKYGRNRGINLKTICVYAHQLMVALQHLAHCGILHCDIKPDNIMVTKSRRSIKLCDFGV PRP4_d_Smoe TNKYGRNRGINLKTICVYAHQLMVALQHLAHCGILHCDIKPDNIMVTKSRRSIKLCDFGV PRP4_b_Smoe LKKFGRNIGISLAAVRSYARQLFTALKHLRNCGVLHCDIKPDNMLVNDSKNLLKLCDFGS PRP4_a_Smoe LKKFGRNIGISLAAVRSYARQLFTALKHLRNCGVLHCDIKPDNMLVNDSKNLLKLCDFGS PRP4_c_Smoe TNKYGRNRGINLKTICVYAHQLMVALQHLAHCGIFHCDIKPDNIMVTKSRRSIKLCDFGV ..:*: *: : .: *: *:: ** : . .*.*:****:::.. :*: *:* PRP4_Hsap ASHVADN---DITPYLVSRFYRAPEIIIGK-SYDYGIDMWSVGCTLYELYTGKILFPGKT PRP4_Mmus ASHVADN---DITPYLVSRFYRAPEIIIGK-SYDYGIDMWSVGCTLYELYTGKILFPGKT F22D6.5_Cele AGRVNEQ---ELAPYLVSRFYRAPEIMLGV-RHDYAIDLWSVAVTLYEVYTGKIMFPGRT Prp4_Ddis AGEIHES---EITPYLVSRFYRAPEIILGH-KYDYSIDVWSVGCCLAEFFTGKFLFPGKT 15575_Tthe ALPIEEN---GIIKYLQSRFYRAPEVLIGY-PPYNQIDVWSVGVTLYEIYTQKILFDGST PRP4_Spur ASHVADN---DITPYLVSRFYRAPEIIIGM-NYDAAIDMWSTGCTIFELAAGKIMFPGKT CG7028_Dmel ASAISDN---EITPYLVSRFYRSPEIILGI-PYDYGIDTWSAGCTIYELYTGKILFSGKS CC1G_04865_Ccin ASDASEN---EITPYLVSRFYRAPEIILGV-PYDPALDVWSIGCTLYELYTGKILFPGRS AqueK115_Aque ASFIQDN---EITPYLVSRFYRAPE----------------------------------- AqueK116_Aque ASFIQDN---EITPYLVSRFYRAPEIIIGC-KYDYGIDMWSVGATLYELYTGQILFPGKS PRP4_e_Smoe AMFARDQTPSAETPYLVSPSYRAPEIILGVAPYSHAIDMWSAGCCLYELYTGKFLFPVAT PRP4_d_Smoe AMFARDQTPSAETPYLVSPSYRAPEIILGVAPYSHPIDMWSAGCCLYELYTGKFLFPVAT PRP4_b_Smoe AMFAGEN---EITPYLVSRFYRAPEIILGL-PYDHALDMWSVGCCLYELYTGKVLFPGST PRP4_a_Smoe AMFAGEN---EITPYLVSRFYRAPEIILGL-PYDHALDMWSVGCCLYELYTGKVLFPGST PRP4_c_Smoe AMFARDQTPSAETPYLVSPSYRAPEIILGVAPYSHQIDMWSAGCCLYELYTGKFLFPVAT * :. ** * **:** PRP4_Hsap NNHMLKLAMDLKGKMPNKMIRKGVFKDQHFDQNLNFMYIEVDKVTEREK----------- PRP4_Mmus NNHMLKLAMDLKGKMPNKMIRKGVFKDQHFDQNLNFMYIEVDKVTEREK----------- F22D6.5_Cele NNHMLKLFTDVKGKYPNKLVRKSQFKDTHFDVNCNLLYQEVDKVTERNK----------- Prp4_Ddis NNDMIRLFMEYRGAFSKKMLKKSEFVSNHFNENLVFMKQEIDNIEKTVR----------- 15575_Tthe NNEMLKLIMDSRGKFNKKMLQNGKYVEEYFDQNYNFKYTYVDKQTNQKY----------- PRP4_Spur NNHMLKLFMDLKGKMPHKIIRKGILRDKHFDPNCNFKYVEVDKVTEREK----------- CG7028_Dmel NNQMLKFFMDVKGKIPNRII---------------------------------------- CC1G_04865_Ccin NNQMLRLMMELKGRFNTKIIKKAKFGETYFDELGAFESVERDRLTGSDI----------- AqueK115_Aque ------------------------------------------------------------ AqueK116_Aque NNEMLKLNMELKGKMSHKMVRKGMFRENHFDSSFNFLYHTVDKVTQKEK----------- PRP4_e_Smoe NNGLLKQQMELKGAFPKAMLKKGAFTGMHFNENFEF--RQLDPVTKLET----------- PRP4_d_Smoe NNGLLKQQMELKGAFPKAMLKKGAFTGMHFNENFEF--RQLDPVTKLET----------- PRP4_b_Smoe NNDMLRLHMELKGPFPKKMLRKAMFTAQHFDQDLNFHAIEEDPVTKKTI----------- PRP4_a_Smoe NNDMLRLHMELKGPFPKKMLRKAMFTAQHFDQDLNFHAIEEDPVTKKVQFCIFPVYSFLH PRP4_c_Smoe NNGLLKQQMELKGAFPKAMLKKGAFTGMHFNENFEF--RQLDPVTKLET----------- PRP4_Hsap -------VTVMSTIN-PTKDLLADLIGCQ--RLPEDQRKKVHQLKDLLDQILMLDPAKRI PRP4_Mmus -------VTVMSTIN-PTKDLLADLIGCQ--RLPEDQRKKVHQLKDLLDQILMLDPAKRI F22D6.5_Cele -------ITVLANLK-PTRDLESELIAGQ--RLSRDQMDQIQAFRTLLDGMLILDPSKRT Prp4_Ddis -------KVPHDITK-PTKDILQFLLPKN-VSIPDQDMKKLIQLKDLIEKCTILDPEKRI 15575_Tthe -------TTIITYGDIPKKDIYRLLQEN-KDGINLENQKKLSQFKDFLDKCLQLDPKNRI PRP4_Spur -------VTVMTVIN-PTKDLTTELLGYQ--RLPEDQQRKVLQLKDVLDRCLMLDPSKRI CG7028_Dmel ----------------------------------------VTQLKDLLENMFALDPAKRI CC1G_04865_Ccin -------TRKIHIQK-PTRDLRARLMPSSSVKLNDEETKMLANFIDLLDKCLMLDPARRI AqueK115_Aque ------------------------------------------------------------ AqueK116_Aque -------VVVMSSFS-PQRDLLADLVGSQ--SPSEAHLRKIHHFKDFLDKIFILDPTKRL PRP4_e_Smoe -------LRSMASFN-VKTSCISDLTG--------EDGALMARFKNLLERMLTLDPSKRI PRP4_d_Smoe -------LRSMASFN-VKTSCISDLTG--------EDGALMARFKNLLERMLTLDPSKRI PRP4_b_Smoe -------NRMITNVK-P-KDI-STLISSS--GGSDEDAKNLLNFKLLLEKIFILDPEKRL PRP4_a_Smoe LLSFQTINRMITNVK-P-KDI-STLISSS--GGSDEDAKNLLNFKLLLEKIFILDPEKRL PRP4_c_Smoe -------LRSMASFN-VKTSCLSDLTG--------EDGALMSRFKNLLERMLTLDPSKRI PRP4_Hsap SINQAL----Q PRP4_Mmus SINQAL----Q F22D6.5_Cele TCNEALKHPFF Prp4_Ddis TPFEA-----L 15575_Tthe TPEEALEHPFL PRP4_Spur SINEVLRHSFI CG7028_Dmel SLNQALVHPFI CC1G_04865_Ccin TPREALSHPFI AqueK115_Aque ----------I AqueK116_Aque SINQALQHPFI PRP4_e_Smoe TPDEALKHPFL PRP4_d_Smoe TPDEALKHPFL PRP4_b_Smoe TVSQALNHPFI PRP4_a_Smoe TVSQALNHPFI PRP4_c_Smoe TPDEALKHPFL