CLUSTAL W (1.83) multiple sequence alignment SIK_Hsap YDIERTLGKGNFAVVKLARHRVTKTQVAIKIID-KTRLDSSNLEKIYREVQLMKLLN--- QSK_Hsap YEIDRTIGKGNFAVVKRATHLVTKAKVAIKIID-KTQLDEENLKKIFREVQIMKMLC--- QIK_Hsap YDIEGTLGKGNFAVVKLGRHRITKTEVAIKIID-KSQLDAVNLEKIYREVQIMKMLD--- CG15072_Dmel YELEKTIGKGNFAVVKLATNIVTKTKVAIKIID-KTCLNEEYLNKTFREIAILKSLR--- kin-29_Cele YDVGRAIGKGNFATVRIARHKIAKTKVAIKSID-VSALDRENLIKLEREVKIVKVID--- QIK_Mmus YDIEGTLGKGNFAVVKLGRHRITKTEVAIKIID-KSQLDAVNLEKIYREVQIMKMLD--- QSK_Mmus YEIDRTIGKGNFAVVKRATHLVTKAKVAIKIID-KSQLDEENLKKIFREVQIMKMLC--- SIK_Mmus YDVERTLGKGNFAVVKLARHRVTKTQVAIKIID-KTRLDSSNLEKIYREVQLMKLLN--- DDB0231454_Ddis YTLGKTLGRGNYGVVKLGTHINTKEEIAIKILY-KEQMTESEFTRCKREIEILKQLY--- QSK_Spur --------------------------VAIKIID-KTQLEGDNIQKIVREVKVMKLLS--- SIK_Spur YDIDRTIGKGNFAVVKLAKHRITKSQVAIKIID-KSRLDESNLKKVYREVQIMKMLS--- CG4290_Dmel YDIERTIGKGNFAVVKLARHRITKNEVAIKIID-KSQLDQTNLQKVYREVEIMKRLK--- AqueK068_Aque YELEKVIGRGNFAIVKLATHTVSKMKVAIKIID-KSRLDKENLKKVQREVEIMKQLD--- AqueK069_Aque YEVKRRLQSGYFGVTWLAENKTTNRDVCLKTFFNESQS-------QRKELVILKQLCEGH :.:* : :*: ::* : SIK_Hsap --HPHIIKLYQVMETK------------DMLYIVTEFAKNGEMFDYLTSNG--------- QSK_Hsap --HPHIIRLYQVMETE------------RMIYLVTEYASGGEIFDHLVAHG--------- QIK_Hsap --HPHIIKLYQVMETK------------SMLYLVTEYAKNGEIFDYLANHG--------- CG15072_Dmel --HPHITRLYEVMESQ------------SMIYLVTEYAPNGEIFDHLVANG--------- kin-29_Cele --HPHIVKSYEIMRVD------------NMLYIVSEYCSSGELYETLIEKG--------- QIK_Mmus --HPHIIKLYQVMETK------------SMLYLVTEYAKNGEIFDYLANHG--------- QSK_Mmus --HPHIIRLYQVMETE------------RMIYLVTEYASGGEIFDHLVAHG--------- SIK_Mmus --HPNIIKLYQVMETK------------DMLYIVTEFAKNGEMFDYLTSNG--------- DDB0231454_Ddis --HPFINKLLNVLEKD------------DAMFILMDYCQGGDLFHYVNKFGLKGVKMVNS QSK_Spur --HPHIIRLYQVMETD------------RYMYLVTEYASGGEIFDHLISHG--------- SIK_Spur --HPNVIKLYQVMETK------------SMLYLVTEYASNGEMFD---THG--------- CG4290_Dmel --HPHIIKLYQVMETK------------NMIYIVSEYASQGEIFDYIAKYG--------- AqueK068_Aque --HPHIIKLYQVMNTT------------QWLYLVTEYASGGEIFDYLIQHR--------- AqueK069_Aque FEHDYICRVLDVCIDRSPVLNGSGVVLGRIQFVVFEYCSGSDLFNFLCSGPWEKH----- * : : :: ::: ::. .:::. SIK_Hsap -----------HLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADF QSK_Hsap -----------RMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADF QIK_Hsap -----------RLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADF CG15072_Dmel -----------RMKEPEAARVFTQLVSAVHYCHRRGVVHRDLKAENVLLDKDMNIKLADF kin-29_Cele -----------RVAENVARKWFSETASAVAYLHSQGIVHRDLKAENILLGKNSNIKIIDF QIK_Mmus -----------RLNESEARRKFWQILSAVDYCHGRKVVHRDLKAENLLLDNNMNIKIADF QSK_Mmus -----------RMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADF SIK_Mmus -----------HLSENEARQKFWQILSAVEYCHNHHIVHRDLKTENLLLDSNMDIKLADF DDB0231454_Ddis PDIGDQVLMGVPLPEDDTKRIFTQICLGIAHCHKLNIAHRDIKHKNILFDNQMNVKIIDF QSK_Spur -----------KMTEREARQKFKQIVAAVHYCHKRGIVHRDLKAENLLLDANMNVKIADF SIK_Spur -----------RMSEKEAKKKFMQIIAAVEYCHKRHVVHRDLKAENLLLDGNMNIKIADF CG4290_Dmel -----------RMSESAARFKFWQIISAVEYCHKKGIVHRDLKAENLLLDLNMNIKIADF AqueK068_Aque -----------KMTESEARKKFKQIVMAVDYCHSRGIVHRDLKAENLLLDENSNVKLADF AqueK069_Aque -------RKVSNFSEPLARHYFKQVLLGVMYLHERGMYHRDIKPENCVLDDNLNLKLTDF . * : * : .: . * : ***:* :* ::. : ::*: ** SIK_Hsap GFGNFYKSGEPLS------TWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSL QSK_Hsap GFSNLFTPGQLLK------TWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGAL QIK_Hsap GFGNFFKSGELLA------TWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGAL CG15072_Dmel GFSNHYEEGATLK------TWCGSPPYAAPEVFQGLEYDGPKSDIWSLGVVLYALVCGAL kin-29_Cele GFSNFQTGDQLLN------TWCGSPPYAAPELLLGNSYDGMKADIWSMGVLLYILVAGGF QIK_Mmus GFGNFFKTGELLA------TWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGAL QSK_Mmus GFSNLFTPGQLLK------TWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGAL SIK_Mmus GFGNFYKPGEPLS------TwcGSPPYAAPEVFEGKEYEGPQLDVWSLGVVLYVLVCGSL DDB0231454_Ddis GLSNWSYQEK--M------SFCGTPAYAAPEMLLGINYNGPEVDIWSLGVILYSLVTGKL QSK_Spur GFSNFFEKDHLLK------TWCGSPPYAAPELFEGREYNGPKADVWSLGVVLYVLVSGAL SIK_Spur GFSNFFVPGEHLA------TWCGSPPYAAPEVFEGQKYDGPQLDIWSLGVVLYVLVCGAL CG4290_Dmel GFSNHFKPGELLA------TWCGSPPYAAPEVFEGKQYTGPEIDIWSLGVVLYVLVCGAL AqueK068_Aque GFSNSFKNEELLK------TWCGSPPYAAPELFEGKEYSGPQADIWSLGVVLYVMVCGAL AqueK069_Aque GTNKYFADADPMKLIRTKTRGVGTETYRAPEVNSGLDYDPAAADVWSLGVTLFFFVGVEQ * .: *: .* ***: * .* *:**:** *: :* SIK_Hsap PFDG-PNLPT-------------------------------LRQRVLEGRFR-------- QSK_Hsap PFDG-STLQN-------------------------------LRARVLSGKFR-------- QIK_Hsap PFDG-PTLPI-------------------------------LRQRVLEGRFR-------- CG15072_Dmel PFDG-KTILE-------------------------------LKSRVVLGKFR-------- kin-29_Cele PFPS-DSVNK-------------------------------LKRSVLSGLVK-------- QIK_Mmus PFDG-PTLPI-------------------------------LRQRVLEGRFR-------- QSK_Mmus PFDG-STLQN-------------------------------LRARVLSGKFR-------- SIK_Mmus PFDG-PNLPT-------------------------------LRQRVLEGRFR-------- DDB0231454_Ddis PFIN-VT-------------------------------------DMIVGKFI-------- QSK_Spur PFDG-KTLHN-------------------------------LRARVLSGQFR-------- SIK_Spur PFDA-NTLPQ-------------------------------LKERVLAGKFR-------- CG4290_Dmel PFDG-STLQS-------------------------------LRDRVLSGRFR-------- AqueK068_Aque PFDG-NNLQH-------------------------------LRARVLAGRFR-------- AqueK069_Aque MFAKVQTLDSYSKQIIAPLGIYFPFPLHCSKLDSYLRREADLRGRGVNGSLKGSALPNES * . : * . SIK_Hsap -------IPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWM QSK_Hsap -------IPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWM QIK_Hsap -------IPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWM CG15072_Dmel -------IPFFMSQECEQLIRNMLVVEPDRRYTIKQIIKHRWL kin-29_Cele -------IPYWVSVECADFIRKMLVLNPGKRYTIQNVLQHRWM QIK_Mmus -------IPYFMSEDCEHLIRRMLVLDPSKRLSIAQIKEHKWM QSK_Mmus -------IPFFMSTECEHLIRHMLVLDPNKRLSMEQICRHKWM SIK_Mmus -------IPFFMSQDCETLIRRMLVVDPAKRITIAQIRQHRWM DDB0231454_Ddis -------LPPSIPLDLQDLIKKMLTVDREHRLNIMNVLNHPWL QSK_Spur -------IPFFMSEGCEDLIRHMLILDASRRYTTDQVLNHRWT SIK_Spur -------IPFFMSQECEHLIRHMLVINPAKRLSIDQIKNHKWF CG4290_Dmel -------IPFFMSSECEHLIRRMLVLEPTRRYTIDQIKRHRWM AqueK068_Aque -------IPFYMSEECEKLIRKMLQLDPSKRIPLSKVLEHKWM AqueK069_Aque FWSEWECLKVSISPGLRDLLNRIFVLDAGLRITLRDILRHPWV : :. ::..:: :: * .: .* *