CLUSTAL W (1.83) multiple sequence alignment ARAF_Hsap -----------VQLLKRIGTGSFGTVFRGRWHGDVA-VKVLKV------SQPTAE--QAQ RAF1_Hsap -----------VMLSTRIGSGSFGTVYKGKWHGDVA-VKILKV------VDPTPE--QFQ BRAF_Hsap -----------ITVGQRIGSGSFGTVYKGKWHGDVA-VKMLNV------TAPTPQ--QLQ ksr-2_Cele TWEDVTIKLTDVDVMTKIGDGRFGSVYFGGYHGNAA-VRFVNM------NYLSQEDRRAD lin-45_Cele -----------FIIQYKVGSGSFGTVYRGEFFGTVA-IKKLNV------VDPTPS--QMA Raf_Spur -----------IRLGSRIGAGSFGTVFSGQWHGSVA-VKRLNV------KDPTPS--QLQ ARAF_Mmus -----------VQLLKRIGTGSFGTVFRGRWHGDVA-VKVLKV------AQPTAE--QAQ BRAF_Mmus -----------ITVGQRIGSGSFGTVYKGKWHGDVA-VKMLNV------TAPTPQ--QLQ RAF1_Mmus -----------VMLSTRIGSGSFGTVYKGKWHGDVA-VKILKV------VDPTPE--QLQ phl_Dmel -----------ILIGPRIGSGSFGTVYRAHWHGPVA-VKTLNV------KTPSPA--QLQ AqueK677_Aque -----------IEVGERIGSGSFGTVYKGKWHGPVA-VKKLNV------SNPTEQ--QMQ AqueK678_Aque -----------IEVGERIGSGSFGTVYKGKWHGPVA-VKKLNV------SNPTEQ--QMQ AqueK679_Aque -----------TILKETLGNGAYGVVYKAKCDELICAAKYMHPIFFALSEDPAVNVVATD : :* * :* *: . . : :: : ARAF_Hsap AFKNEM-QVLRKTRHVNILLFMGFMTRP---GFAIITQWCE--GSSLYHHLHVA-DTR-- RAF1_Hsap AFRNEV-AVLRKTRHVNILLFMGYMTKD---NLAIVTQWCE--GSSLYKHLHVQ-ETK-- BRAF_Hsap AFKNEV-GVLRKTRHVNILLFMGYSTKP---QLAIVTQWCE--GSSLYHHLHII-ETK-- ksr-2_Cele VFATEIVSAykNSRHDHIALFYGYVSDPVTNTYAIVTNFYQ--HNTLYHRIHEQLSED-- lin-45_Cele AFKNEV-AVLKKTRHLNVLLFMGWVREP---EIAIITQWCE--GSSLYRHIHVQ-EPRVE Raf_Spur AFKNEV-AVLRKTRHANILLFMGCTSKP---QLAIVTQWCE--GSSLYKHLHVL-DTK-- ARAF_Mmus AFKNEM-QVLRKTRHVNILLFMGFMTRP---GFAIITQWCE--GSSLYHHLHVA-DTR-- BRAF_Mmus AFKNEV-GVLRKTRHVNILLFMGYSTKP---QLAIVTQWCE--GSSLYHHLHII-ETK-- RAF1_Mmus AFRNEV-AVLRKTRHVNILLFMGYMTKD---NLAIVTQWCE--GSSLYKHLHVQ-ETK-- phl_Dmel AFKNEV-AMLKKTRHCNILLFMGCVSKP---SLAIVTQWCE--GSSLYKHVHVS-ETK-- AqueK677_Aque AFKNEV-AVLMKTRHANILLFMGWTSKP---RLTIVTQWCD--GSTLFSHIHVL-EDR-- AqueK678_Aque AFKNEV-AVLMKTRHANILLFMGWTSKP---RLTIVTQWCD--GSTLFSHIHVL-EDR-- AqueK679_Aque KFKKEC-QLLSRLKHPNIVQYLGTHEVN---GIDTVVLLMELMDSSLHAYLHAHVDSP-- * .* . :* :: : * :. : .:*. :* . ARAF_Hsap FDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGL-TVKIGDFGLATVKTRWS- RAF1_Hsap FQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL-TVKIGDFGLATVKSRWS- BRAF_Hsap FEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDL-TVKIGDFGLATVKSRWS- ksr-2_Cele FDQSWTFQISLQICQAMSYLHKKKILHRDLRTKNILLDNPN-RVVVTDFALMKLERLENP lin-45_Cele FEMGAIIDILKQVSLGMNYLHSKNIIHRDLKTNNIFLMDDMSTVKIGDFGLATVKTKWTV Raf_Spur LVMHQLIDISRQTAQGMDYLHAKNIIHRDLKSNNIFLHDDL-TVKIGDFGLATVKSRWS- ARAF_Mmus FDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGL-TVKIGDFGLATVKTRWS- BRAF_Mmus FEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDL-TVKIGDFGLATVKSRWS- RAF1_Mmus FQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL-TVKIGDFGLATVKSRWS- phl_Dmel FKLNTLIDIGRQVAQGMDYLHAKNIIHRDLKSNNIFLHEDL-SVKIGDFGLATAKTRWS- AqueK677_Aque FEMYKIIDICRQTAQGVDYLHAKQIIHRDLKSNNIFLHDDM-TVKIGDFGLATVKTRWD- AqueK678_Aque FEMYKIIDICRQTAQGVDYLHAKQIIHRDLKSNNIFLHDDM-TVKIGDFGLATVKTRWD- AqueK679_Aque LPFHQEINISLDVARALDYLHVNNIHHRDLSAKNILMLGDY-RAKVSDFGQSKLRNPNG- : ::: : . .:.*** :.* ***: ::**:: . : **. . . ARAF_Hsap -GAQPLEQPSGSVLWMAAEV-----------IRMQDPNPYSFQSDVYAYGVVLYELMTGS RAF1_Hsap -GSQQVEQPTGSVLWMAPEV-----------IRMQDNNPFSFQSDVYSYGIVLYELMTGE BRAF_Hsap -GSHQFEQLSGSILWMAPEV-----------IRMQDKNPYSFQSDVYAFGIVLYELMTGQ ksr-2_Cele RRNCTLLIPNHWIDYLSPEIAGNLMIDWRGDVLFQHELPFSQESDVYSFGTIFFELLLRR lin-45_Cele NGGQQQQQPTGSILWMAPEV-----------IRMQDDNPYTPQSDVYSFGICMYEILSSH Raf_Spur -GSQQFEQPSGSILWMAPEV-----------IRMRDTNPYSFQSDVYAFGVVLFELVTQS ARAF_Mmus -GAQPLEQPSGSVLWMAAEV-----------IRMQDPNPYSFQSDVYAYGVVLYELMTGS BRAF_Mmus -GSHQFEQLSGSILWMAPEV-----------IRMQDKNPYSFQSDVYAFGIVLYELMTGQ RAF1_Mmus -GSQQVEQPTGSVLWMAPEV-----------IRMQDDNPFSFQSDVYSYGIVLYELMAGE phl_Dmel -GEKQANQPTGSILWMAPEV-----------IRMQELNPYSFQSDVYAFGIVMYELLAEC AqueK677_Aque -GNEKVRQPTGSILWMAPEV-----------IRMEEPDPYTFYCDVYSFGVVVYELISGQ AqueK678_Aque -GNEKVRQPTGSILWMAPEV-----------IRMEEPDPYTFYCDVYSFGVVVYELISGQ AqueK679_Aque -GFSSNSPCPGNILYMPPET-----------LKVP--PDFAPTLDEFSFGIVTIQIMSRK : ::..* : . :: * :::* ::: ARAF_Hsap LPYSHIGCRDQIIF--MVGRGYLSPDLSKISSNC-----PKAMRRLLSDCLKFQREERPL RAF1_Hsap LPYSHINNRDQIIF--MVGRGYASPDLSKLYKNC-----PKAMKRLVADCVKKVKEERPL BRAF_Hsap LPYSNINNRDQIIF--MVGRGYLSPDLSKVRSNC-----PKAMKRLMAECLKKKRDERPL ksr-2_Cele MPTG-CDSWDQKLYAKMCGQKAALQRLDAQLQKI-----DGKLHELLLECWSSQPEKRPS lin-45_Cele LPYSNINNRDQILF--MVGRGYLRPDRSKIRHDT-----PKSMLKLYDNCIMFDRNERPV Raf_Spur LPYQNIKHKDQIIW--MVGRGYLQPDLSKVRNDT-----PKALKRLITDCYALNRDERPL ARAF_Mmus LPYSHIGSRDQIIF--MVGRGYLSPDLSKIFSNC-----PKAMRRLLTDCLKFQREERPL BRAF_Mmus LPYSNINNRDQIIF--MVGRGYLSPDLSKVRSNC-----PKAMKRLMAECLKKKRDERPL RAF1_Mmus LPYAHINNRDQIIF--MVGRGYASPDLSRLYKNC-----PKAMKRLVADCVKKVKEERPL phl_Dmel LPYGHISNKDQILF--MVGRGLLRPDMSQVRSDA-----PQALKRLAEDCIKYTPKDRPL AqueK677_Aque LPYPHVQDRDQILF--MVGRGFLRPDPSSARKDT-----PKSFKQLCIKCCQFEKDDRPL AqueK678_Aque LPYPHVQDRDQILF--MVGRGFLRPDPSSARKDT-----PKSFKQLCIKCCQFEKDDRPL AqueK679_Aque DPKPSDLHRTG--S--LIGTLVEVPEIERRRDDIDSCDPSNPILGLSISCISNDPQERPP * : * . . : * .* ..** ARAF_Hsap FPQILAT-------I RAF1_Hsap FPQILSSI-----EL BRAF_Hsap FPQILASI-----EL ksr-2_Cele FQQIVKRITVQMPRK lin-45_Cele FGEVLER-------L Raf_Spur FPVVLAA-------L ARAF_Mmus FPQILAT-------I BRAF_Mmus FPQILASI-----EL RAF1_Mmus FPQILSSI-----EL phl_Dmel FRPLL--------NM AqueK677_Aque FHQILADL-----ES AqueK678_Aque FHQVYNNLE----SL AqueK679_Aque IERMCQLLS----LL : :