CLUSTAL W (1.83) multiple sequence alignment 8635_Tthe -----------------------------AMKVVDKKRK--------------------- 8635~b_Tthe -DQSEIN-------------EQIKRQSQ-------------------------------- PLK4_Hsap -FK-VGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAM--------------------- 5034_Tthe -YI-ISHPIGSGAGSLVVKVKSIKTKKEYAIKVVDKQSQ--------------------- 21183_Tthe ------------------------------------------------------------ SAK_Spur -YQ-VLNLLGRGGFACVYRAKTISTGQEVAIKMIDKKLM--------------------- PLK4_Mmus -FK-VGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAM--------------------- SAK_Dmel -YE-VQHLLGKGGFATVYKARCLHTHQDVAIKMIDKKLI--------------------- zyg-1_Cele -YS-HLKEIGKGGFGVVYAAQR-ENGEKVAIKRVSFMLFSKDIRMGQFFYFFSLQKLYFQ AqueK201_Aque DYE-VLNRLGKGSFADVYRAKCKRTKKEVAIKMIDKKLM--------------------- 8635_Tthe -DIQNVMKRLDQEIKIQKELDH-PNIIKLFKHFEDDQNHYLIMELAQNGEIKDYLNI--- 8635~b_Tthe IVQKKDDLKILNEIEIIGDIQNI-EQINKG-----------GFGSIQKGKLAKILKYPLY PLK4_Hsap -YKAGMVQRVQNEVKIHCQLKH-PSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNR-- 5034_Tthe -YYKSAYKRLKNEIEIHLDLKH-KNIVKMIKSFEDSENLYLVMEYCEGGDLFHYLKH--- 21183_Tthe ---------------LHSQLDH-PNIVKILKRFEDNEYVYMMLEYCPGGSLFDYIVYINF SAK_Spur -QSSGMATRVKNEVEIHCQLKH-PSILELYSYFEDNNYVYLVLELAQNGELLRYLKKK-- PLK4_Mmus -YKAGMVQRVQNEVKIHCQLKH-PSVLELYNYFEDNNYVYLVLEMCHNGEMNRYLKNR-- SAK_Dmel -QGTGLTNRVRQEVEIHSRLKH-PSVLQLYTFFQDANYVYLVLELAHNGELHRYMNHI-- zyg-1_Cele IDKKVPKNRVWTEIQTMKELKKSKYVVEFYEDFVEDGYTYIVMELCEGGSLQAYVREH-- AqueK201_Aque -VKKGMTERVKNEVKIHSHLKH-PSILELYDFFEDSNYVYLILEFCQNGELNRYLKHR-- :.: :: : *.: : 8635_Tthe ----NK----------PYQLACGIKYLHDKDIVHRDLKLNNVLLSN-----GKIKIADFG 8635~b_Tthe G-HFSQTMSLITKLYIMWQIAQGIQFLTSKNVAHLDLKPANIVISK----GYLAKIIDFG PLK4_Hsap ----VKPFSENEARHFMHQIITGMLYLHSHGILHRDLTLSNLLLTR----NMNIKIADFG 5034_Tthe ----HKKLSETEAKRITYKLAEGLKYLHDKSIIHRDLKLGNVLLSS----DHQVKICDFG 21183_Tthe QLFEKTRLNEDEARDISYQIVQGLEYLHKNKIIHRDLKPGNILLTG----NNSVKICDFG SAK_Spur ----ARVFGEEEARQFLEEIVIGLLYLHSHGILHRDLTLANILLTR----DMHCKIADFG PLK4_Mmus ----MKPFSEREARHFMHQIITGMLYLHSHGILHRDLTLSNILLTR----NMNIKIADFG SAK_Dmel ----ARPFTETEAASILKQVVAGLLYLHSHNIMHRDISLSNLLLSR----EMHVKIADFG zyg-1_Cele -----GALDDATAVHVLRQLISAVSFMHRVNVIHRDLSAGNVFIKDSKKKKMTVKLGDFG AqueK201_Aque ----QKSLSEDE-RIILNQVVKGLIYLHSFNIVHRDLSLSNILLTS----SMDIKIADFG :: .: :: : * *:. *:.:. *: *** 8635_Tthe LATKVNDE-------------NPECNTMCGTANYLSP-----------------EILN-- 8635~b_Tthe EAYHPDVCNGKEFYNNQQRLIFKSYFLMKGNPNYKPG-----------------RTLPYT PLK4_Hsap LATQLKMP-------------HEKHYTLCGTPNYISP-----------------EIAT-- 5034_Tthe LAVRLNGN-------------EQEKNTICGTPNYISP-----------------EILN-- 21183_Tthe LAVRVTNY-------------ESERDTFCGTPNYIAP-----------------E----- SAK_Spur LAAQLKLP-------------EEQHYTMCGTPNYISP-----------------EIAT-- PLK4_Mmus LATQLNMP-------------HEKHYTLCGTPNYISP-----------------EIAT-- SAK_Dmel LATQLKRP-------------DERHMTMCGTPNYISP-----------------EVVS-- zyg-1_Cele LATTLGRG--------------ETTCTIVGTPGFIAP-----------------QVYD-- AqueK201_Aque LSVTLDLP-------------GDKHHTLCGTPNYIAPYVICCYEGCFLIFIFCREVAK-- : : *...: . . 8635_Tthe -------SKGYGKKTDIWSFGCILYALCSGNLPFFSGNPSQTIQNIK----E-------- 8635~b_Tthe PYSNNNDRQASYKNLDIFSFGMVLSEIVFDTYPVDFK--RGALHKLEEKFSRGDIRGRLV PLK4_Hsap -------RSAHGLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVV----L-------- 5034_Tthe -------KQPYGMKIDCWSFGCILYALIVGHPPFQGQDIVQTLKKVT----S-------- 21183_Tthe ---------KYGIQSDCWSFGCILYTIATGRPPFETVSIQQTLKMLQ----K-------- SAK_Spur -------RGPHGLQSDVWSLGCMLYTFLTGTPPFDTEAVKTTLNKVM----L-------- PLK4_Mmus -------RSAHGLESDIWSLGCMFYTLLIGRPPFDTDTVKNTLNKVV----L-------- SAK_Dmel -------RTSHGLPADVWSVGCMLYTLLVGRPPFETDAVQSTLNKVV----M-------- zyg-1_Cele --------QEYTQSADVYSLGAVLYTMLTARNPPPKGLP-P------------------- AqueK201_Aque -------REAHGLESDIWSLGCMVYTMLVGTPPFDTDDVQSTLDNVV----N-------- * :*.* :. : * 8635_Tthe GK---WQLPQNISDNVKDLLSNTLNWDQNSRFSIEQVLSHKFY 8635~b_Tthe KNYQRHFGPKHIINLLHCLIFRCID-EKENRPTIDWI---ILI PLK4_Hsap AD---YEMPSFLSIEAKDLIHQLLRRNPADRLSLSSVLDHPFM 5034_Tthe QEQ-FFELPNNISDNLKDLLVNIINWNQDSRFTIDQILMHPFY 21183_Tthe KN--KVEYPSHLSKSLVDLIDHILDWNQDTRYNISQIKSHPFY SAK_Spur AE---YIIPTHISMEAKDLINKMLRKDPTERIGLSTVLDHPFM PLK4_Mmus AD---YEMPAFLSREAQDLIHQLLRRNPADRLSLSSVLDHPFM SAK_Dmel SE---YIMPAHLSYEAQDLINKLLKKLPHERITLEAVLCHPFM zyg-1_Cele --------TCGMSPNAARLVEQMMDTDAKKRIPLTQIVLSEFM AqueK201_Aque GD---FDIPQYITTNCTSLNLH--VYHPSKRLTLQQVLYHS-F . : * . * : :