CLUSTAL W (1.83) multiple sequence alignment E02D9.1_Cele LQRGKYVGNGMHATVRMALHEKTQKWYVIKTILS-------QNTDKTEY---EKEILAYE F35C8.1_Cele LYGGERIGNGEGQSAVYRL-IYNGKLIARKDVAVRLPKGVDQDSTNKLMAKKLREVNVIN F35C8.2_Cele LHGGVRIGSGEGQSAVYRL-IYNGMVIARKDVAVRLPQGGDEDSTNKLMAKRLREVNVIN MKK1_Scer IETLGILGEGAGGSVSKCKLKNGSKIFALKVINTL-------NTDPEYQKQIFRELQFNR MKK2_Scer ITTLGILGEGAGGSVAKCRLKNGKKVFALKTINTM-------NTDPEYQKQIFRELQFNK PBS2_Scer LEFLDELGHGNYGNVSKVLHKPTNVIMATKEVRL--------ELDEAKFRQILMELEVLH STE7_Scer LVQLGKIGAGNSGTVVKALHVPDSKIVAKKTIPVE-------QNNSTIINQLVRELSIVK 1557_Tthe ------------------------------------------------------------ 1909_Tthe LRRVKVLGHGSSGLVELAVHDATGIVIGIKSIPLL--------MNSSFRKQLDQELKTLI 26687_Tthe FEVVSELGKGAFGKVYKVCHKKDGKIYAMKEIIMV--------DDIELRQKILMEVKTLF Mek1_Ddis LKIIRVLGRGAGGVVKLAYHETSGTYIALKVITLD--------IQENIRKQIILELKTLH 12278_Tthe FETISELGRGASGRVFKVKHKETGKFYAKKEIRIN--------DDEMFQKQLIWEIKTLF CC1G_01983_Ccin FEEISRLGEGAGGAVHKVKDKRNGMIMARKTITT--------R--EAPMKQLLRELTIMS CC1G_14241_Ccin QLDDEELGRGNYGTVKKVLHKPTNVAMAMKEIRD--------SI-QANSPAIIMELDVLH E02D9.1_Cele ECSQSDYVVGYHGCEVSS----IKKELVLEYMDKGD-----------F------------ F35C8.1_Cele GCAPCPFIVHFFGYYVHKYRDCVKIHIFMEEMALSA-SVLKT---EAL------------ F35C8.2_Cele GCAPCPFIVHFFGYYVHKYKDCVKIHIFMEEMALSA-SVLKK---EVL------------ MKK1_Scer SFQ-SEYIVRYYGMFTDDE--NSSIYIAMEYMGGRSLDAIYK---NLL------------ MKK2_Scer SFK-SDYIVQYYGMFTDEQ--SSSIYIAMEYMGGKSLEATYK---NLL------------ PBS2_Scer KCN-SPYIVDFYGAFFIE----GAVYMCMEYMDGGSLDKIYD---ESS------------ STE7_Scer NVKPHENIITFYGAYYNQHI-NNEIIILMEYSDCGSLDKILSVYKRFV------------ 1557_Tthe ----HPNLITCFGAYYEE----GTIKIILELMDFGSIRNLID---M-------------- 1909_Tthe QCE-SDSIVKCYGAYIQK----CMINITLEYMDLGTVHDLVK---K-------------- 26687_Tthe ICQ-SPYIVTYYGAFYTE----GKLHIILEYMDVGTLDSLLK---K-------------- Mek1_Ddis KTS-YPYIVSFYDAFYTE----GSIFIALEFMELGSLSDIMK---K-------------- 12278_Tthe SCN-SPHIVQYYCAFYTE----CMLHLILEYMDMGTLDTILK---K-------------- CC1G_01983_Ccin STK-HVNIITFYGAYMSPS--SSEIKIIMEYCEGGSLESVGK---RIR------------ CC1G_14241_Ccin RAV-APEIVEFYGAFFIE----SCVYYCMEYMDAGSLDKLIQ---SNSQPPQPQIPKPPS :: . :* E02D9.1_Cele --------------------------------------------------RP------FG F35C8.1_Cele --------------------------------------------------KQ------GG F35C8.2_Cele --------------------------------------------------KR------GG MKK1_Scer --------------------------------------------------ER------GG MKK2_Scer --------------------------------------------------KR------GG PBS2_Scer ---------------------------------------------------E------IG STE7_Scer --------------------------------------------------QRGTVSSKKT 1557_Tthe ----------------------------------------------------------LK 1909_Tthe ----------------------------------------------------------VG 26687_Tthe ---------------------------------------------------A------GG Mek1_Ddis ----------------------------------------------------------TS 12278_Tthe ----------------------------------------------------------TK CC1G_01983_Ccin --------------------------------------------------ER------GA CC1G_14241_Ccin SDPIQTDASSPEYSFAMPFVEEDLDLTKDENFEPYNRAFNRTCPPPIPSTYS------GG E02D9.1_Cele ILPFSVHQ------------SVALSLIRAIRHVWNSGPGYIHRDIKPENILVN-SQGYVK F35C8.1_Cele AIPEFVIG------------RIVCSVIHAMWFLKD-RLQIIHRDIKPGNILID-YDGRVK F35C8.2_Cele IVPEFVIG------------RIACSVIHAMWFLKE-KMQIIHRDIKPGNILID-YDGRVK MKK1_Scer RISEKVLG------------KIAEAVLRGLSYLHE-K-KVIHRDIKPQNILLN-ENGQVK MKK2_Scer RISERVIG------------KIAESVLRGLSYLHE-R-KVIHRDIKPQNILLN-EKGEIK PBS2_Scer GIDEPQLA------------FIANAVIHGLKELKE-QHNIIHRDVKPTNILCSANQGTVK STE7_Scer WFNELTIS------------KIAYGVLNGLDHLYR-QYKIIHRDIKPSNVLIN-SKGQIK 1557_Tthe EINYCYLSKILCNQKYQYHFFILKQLLKGLEFLHK-ERHQVHRDIKPENILIN-KRGNVK 1909_Tthe PLPEIIVA------------IMAIQVLKGLDYIHN-KAKVIHRDIKPSNLLVN-SKGQVK 26687_Tthe KVSEVVLK------------YLTYQILKGLKYLHK-DLHIIHRDIKPGNILVN-SKGEIK Mek1_Ddis TIPEPVLG------------KIAFQVLQGLVYLHR-KLHLIHRDIKPSNILVN-NKGEAK 12278_Tthe QVSEPILI------------YTTYQIIKGIHYLHK-DLKIIHRDLKPGNILVN-SEGEIK CC1G_01983_Ccin IVGEKIAG------------RLAEGVLQGLSYLHS-K-KTIHRDIKPSNILLS-KEGVVK CC1G_14241_Ccin PIPEAILG------------RIAASMVRGLKFLKD-ELNIIHRDVKPTNVLVN-CKGQVK . ::..: : :***:** *:* . * * E02D9.1_Cele ICDFGAAKRIDNTYRIASSAAGTQMYQAPEQQ-----MGQ-------------------- F35C8.1_Cele ICDFGICGILENS--IAVSDTGCQQYTAPEILVKGVSNSP-------------------- F35C8.2_Cele ICDFGISGILQDS--IAVSATGCQQYTAPEINELAMVHSP-------------------- MKK1_Scer LCDFGVSGEAVNSL--ATTFTGTSFYMAPERI-----QGQ-------------------- MKK2_Scer LCDFGVSGEAVNSL--AMTFTGTSFYMAPERI-----QGQ-------------------- PBS2_Scer LCDFGVSGNLVASL--AKTNIGCQSYMAPERI-----KSLN------------------- STE7_Scer LCDFGVSKKLINSI--ADTFVGTSTYMSPERI-----QGN-------------------- 1557_Tthe LTDFGISKQLEKTQQLCMTYVGTTLYMSPERL-----IGN-------------------- 1909_Tthe IADFGVSANLESAVE-VKNWVGTVTYMSPERF-----RGQ-------------------- 26687_Tthe ISDLGICGAINATLDERQTFVGTSIYMSPERL-----SGE-------------------- Mek1_Ddis IADFGVSGQLQHTLSKAVTWVGTVTYMSPERI-----SGR-------------------- 12278_Tthe ISDLGICGKVNGTMDQKNTFVGTTIYMSPERL-----NGD-------------------- CC1G_01983_Ccin LCDFGVSGELILSQ--AGTFTGTSFYMAPERI-----QGK-------------------- CC1G_14241_Ccin LCDFGVSGQLDKSM--AKTNIGCQSYMAPERI-----RGESRVVGAVPASEGGTGTAAAA : *:* . : . * * :** . E02D9.1_Cele ----------------DYSEKVDIWCFGLTLWEFAIGPNLEEY----------------- F35C8.1_Cele ----------------GYSIKSDIWSLGITIFELATLRYPYPVG---------------- F35C8.2_Cele ----------------GYSIKSDIWSLGITIFELAT------------------------ MKK1_Scer ----------------PYSVTSDVWSLGLTILEVANGKFPCSSEKMA------------- MKK2_Scer ----------------PYSVTCDVWSLGLTLLEVAGGRFPFESDKIT------------- PBS2_Scer ------------PDRATYTVQSDIWSLGLSILEMALGRYPYPPETY-------------- STE7_Scer ----------------VYSIKGDVWSLGLMIIELVTGEFPLGGHNDT------------- 1557_Tthe ----------------QYGLRSDIWSVGLVIIELATGLYPYDVK---------------- 1909_Tthe ----------------AYTANTDIWSLGLTICECALGTYPYFDSNQYEK----------- 26687_Tthe ----------------SYSVKTDIWSFGLLLLEFSESKNPLQLNE--------------- Mek1_Ddis ----------------SYSFDSEIWSLGLTILECAIGKFPYGSNLPHQQQQPLQQQQQQQ 12278_Tthe ----------------SYTMKTDIWSVGLLLIEFSEGKHPIQAS---------------- CC1G_01983_Ccin ----------------EYTIRSDVWSTGISLLELVQNRFPFPPD---------------- CC1G_14241_Ccin QGGVPGTAALADELYGAYTVSSDVWSLGLSIIELGLGRYPYPPETY-------------- * ::*. *: : * E02D9.1_Cele ------------------------------------------------------------ F35C8.1_Cele ------------------------------------------------------------ F35C8.2_Cele ------------------------------------------------------------ MKK1_Scer ------------------------------------------------------------ MKK2_Scer ------------------------------------------------------------ PBS2_Scer ------------------------------------------------------------ STE7_Scer ------------------------------------------------------------ 1557_Tthe ------------------------------------------------------------ 1909_Tthe ------------------------------------------------------------ 26687_Tthe ------------------------------------------------------------ Mek1_Ddis QQQQQPLQQQQQQQQQQQQPLQLQLQNLDINNSNNNIRNSNNNNNNNNNNNNNNNNNNNN 12278_Tthe ------------------------------------------------------------ CC1G_01983_Ccin ------------------------------------------------------------ CC1G_14241_Ccin ------------------------------------------------------------ E02D9.1_Cele --------------------LNGLSSYEEITVE-----PI-------------------- F35C8.1_Cele --------------------FSEFTLLSAIVTTPAPYLER-------------------- F35C8.2_Cele ------------------------------------------------------------ MKK1_Scer ------------------ANIAPFELLMWILTFT-PELKDEPE----------------- MKK2_Scer ------------------QNVAPIELLTMILTFS-PQLKDEPE----------------- PBS2_Scer --------------------DNIFSQLSAIVDGPPPRLPS-------------------- STE7_Scer -------------------PDGILDLLQRIVNEPSPRLPKD------------------- 1557_Tthe -------------------NKSIVQFVSNILQSKEPTLPDN------------------- 1909_Tthe -----------------KENLSFWELLEYFNMKPAPRLPE-------------------- 26687_Tthe -------------------NASFFEILAKVMNFSIPELNS-------------------- Mek1_Ddis NVLDISNGGLVDSGSSVPEGMGFWVLLDCIVKEEVPILPS-------------------- 12278_Tthe --------------------NNFFEVLNNIIDFKIPPLKN-------------------- CC1G_01983_Ccin --------------------LPPIELMMYITNSEPPRLEDEP------------------ CC1G_14241_Ccin --------------------SNVFAQLTAIVHGPPPCLPSGPPPPLSPDDDSSFEEPVLP E02D9.1_Cele ------------------DGFPESLAVLISNCLYS-------HTNFV----------KMF F35C8.1_Cele ------------------VTFSN------------------------------------- F35C8.2_Cele ------------------------------------------------------------ MKK1_Scer ----------------SNIIWSPSFKSFIDYCLKKDSRERPSPRQMI----------NHP MKK2_Scer ----------------LDISWSKTFRSFIDYCLKKDARERPSPRQML----------KHP PBS2_Scer ------------------DKFSSDAQDFVSLCLQKIPERRPTYAALT----------EHP STE7_Scer ------------------RIYSKEMTDFVNRCCIKNERERSSIHELL----------HHD 1557_Tthe ------------------GKYSAALMDFVKKCVAKEQKDRLDISDLL----------KHE 1909_Tthe -------------------NYSEEMKDFVAKCFKKSPLDRPHSHDLL----------NHE 26687_Tthe -------------------IKSKEFIQFVEQCTKINPKERADVVQLL----------ELP Mek1_Ddis -------------------TFSKEFRSFISECLQKEPTERPTASNLL----------NHE 12278_Tthe -------------------INSPEFTNFIEICLKSDQNERADITQLLVNTTSFSSFNEHP CC1G_01983_Ccin -----------------GVNWSEEMKDFIKQALTVDPVDRPTPKDML----------EHP CC1G_14241_Ccin PTLDDQDPLISPTTGRQRPGYSPFARDWVNKCMRKDAKERATYKELL----------EHP E02D9.1_Cele FL F35C8.1_Cele NY F35C8.2_Cele LT MKK1_Scer WI MKK2_Scer WI PBS2_Scer WL STE7_Scer LI 1557_Tthe WI 1909_Tthe MV 26687_Tthe FV Mek1_Ddis FV 12278_Tthe FL CC1G_01983_Ccin WI CC1G_14241_Ccin WL