CLUSTAL W (1.83) multiple sequence alignment TGFbR2_Hsap IELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFP--YEEYASWKTEKDIFSD--IN- MISR2_Hsap LCFSQVIREGGHAVVWAGQLQG------KLVAIKAFP--PRSVAQFQAERALYEL--PG- MISR2_Mmus LRFSQVIQEGGHAVVWAGRLQG------EMVAIKAFP--PRAVAQFRAERAVYQL--LG- BMPR2_Mmus LKLLELIGRGRYGAVYKGSLDE------RPVAVKVFS--FANRQNFINEKNIYRV--PL- ACTR2B_Mmus LQLLEIKARGRFGCVWKAQLMN------DFVAVKIFP--LQDKQSWQSEREIFST--PG- ACTR2_Mmus ----EVKARGRFGCVWKAQLLN------EYVAVKIFP--IQDKQSWQNEYEVYSL--PG- daf-4_Cele ITDFQLISKGRFGKVFKAQYTPDS-GEKRLVAVKKLN--EFQKASFLAEKRIFDE--LNE BMPR2_Hsap LKLLELIGRGRYGAVYKGSLDE------RPVAVKVFS--FANRQNFINEKNIYRV--PL- put_Dmel IQLLEQKASGRFGDVWQAKLNN------QDVAVKIFR--MQEKESWTTEHDIYKL--PR- wit_Dmel MNLIGMLGSGKYGTVMKGLLHD------QEVAVKIYP--EEHHQYYVNERNIYAL--PL- TGFBR2_Mmus IELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFP--YEEYSSWKTEKDIFSD--IN- ACTR2B_Hsap LQLLEIKARGRFGCVWKAQLMN------DFVAVKIFP--LQDKQSWQSEREIFST--PG- ACTR2_Hsap ----EVKARGRFGCVWKAQLLN------EYVAVKIFP--IQDKQSWQNEYEVYSL--PG- TGFbRII_Spur ITLDELIGKGRFGAVWRAHWKINNGTKERTVAVKVFL--EYDSASWNVEKELFTDHSVM- ACTR2_Spur IQLLEIKARGRFGAVWKASCLN------DIVAVKVFP--IQDRNSWANEREIYSL--PH- BMPR2_Spur LKMMELVGQGRYCNVYRAALSE------NEVAVKVFT--GSSKQCYMNELDIMGL--PH- AqueK683_Aque ------------------------------------------LSQWKIERDIYLT--PE- AqueK684_Aque PEFMKIIGHGRFARVYHARMGT------RDVAIKIFNGTLQAKGSWTQEKDIYAT--ER- AqueK685_Aque FQLIQSIGNGRFGSVWKALYEK------ETVAVRVFS--QRHRTSWQNERDIHLL--NS- AqueK686_Aque FQLLQPIGNGRFGSVWKALYNN------ETVAVKALS--LHHKLSWQNERDIHLL--DS- : * : TGFbR2_Hsap --LKHENILQFLTAEERKTE---LGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSS MISR2_Hsap --LQHDHIVRFITASRGGPG--RLLSGPLLVLELHPKGSLCHYLTQYTSDWGSSLRMALS MISR2_Mmus --LQHDHIVRFITAGQGGPG--PLPSGPLLVLELYPKGSLCHYLTQYTSDWGSSLRMALS BMPR2_Mmus --MEHDNIARFIVGDERLTA--DGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSCRLAHS ACTR2B_Mmus --MKHENLLQFIAAEKRGSN---LEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAET ACTR2_Mmus --MKHENILQFIGAEKRGTS---VDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAET daf-4_Cele YPKWYKSIVEFVCAEKIG-------DEYWIVTEFHERLSLYELLKNNVISITSANRIIMS BMPR2_Hsap --MEHDNIARFIVGDERVTA--DGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSCRLAHS put_Dmel --MRHPNILEFLGVEKHMD-----KPEYWLISTYQHNGSLCDYLKSHTISWPELCRIAES wit_Dmel --MECPALLSYFGYDERCTM--DGRMEYQLVLSLAPLGCLQDWLIANTLTFSECCGMLRS TGFBR2_Mmus --LKHENILQFLTAEERKTE---LGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSS ACTR2B_Hsap --MKHENLLQFIAAEKRGSN---LEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAET ACTR2_Hsap --MKHENILQFIGAEKRGTS---VDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAET TGFbRII_Spur --MRHEHIVQFISAEVRRVSVTSPTRQYWLITKYYKNGSLHDYLRQRSVNWIDLCKLCGS ACTR2_Spur --MHHENLLHFIATEKHGEG---LEVEYWLISEFHHHGSLCDYLKANVISWKELCGIAFS BMPR2_Spur --MEHSNLLQYVGSGDRMGE--DGWVEHLLVVDMISKGSLMSYLRENTYDWHTMCRLAQT AqueK683_Aque --LRHESILTLLRAK-RV--KD---IGYQLVLKGSITGSLYQYLQSHSPDELEAAKITHS AqueK684_Aque --LEHENILKFLYHDHRFHE---GQDTLWLIFDYHSNGSLYDYLQLHRLTFDELFSLCLS AqueK685_Aque --TPHENILKFISSESRGRG---PSSEYFIITEYLPLGSLHQFLRHNTLSWEQAWNIMYS AqueK686_Aque --TPHENILKFISSESRGRG---SSSEYFIITEYLPLGSLHQFLRHNTLSWEQAWNIMYS : . :: * * : : TGFbR2_Hsap LARGIAHLHSDHTPC----GRPKMPIVHRDLKSSNILVKND-LTCCLCDFGLSLRLDPTL MISR2_Hsap LAQGLAFLHEERWQ--N--GQYKPGIAHRDLSSQNVLIRED-GSCAIGDLGLALVLPGLT MISR2_Mmus LAEGLAFLHEERWQ--D--GQYKPGIAHRDLSSQNVLIRED-RSCAIGDLGLALVLPGLA BMPR2_Mmus VTRGLAYLHTELPR--G--DHYKPAISHRDLNSRNVLVKND-GACVISDFGLSMRLTGNR ACTR2B_Mmus MSRGLSYLHEDVPWCRG--EGHKPSIAHRDFKSKNVLLKSD-LTAVLADFGLAVRFEPGK ACTR2_Mmus MARGLAYLHEDIPGL-K--DGHKPAISHRDIKSKNVLLKNN-LTACIADFGLALKFEAGK daf-4_Cele MIDGLQFLHDDRPYFF---GHPKKPIIHRDIKSKNILVKSD-MTTCIADFGLARIYSYDI BMPR2_Hsap VTRGLAYLHTELPR--G--DHYKPAISHRDLNSRNVLVKND-GTCVISDFGLSMRLTGNR put_Dmel MANGLAHLHEEIPASKT--DGLKPSIAHRDFKSKNVLLKSD-LTACIADFGLAMIFQPGK wit_Dmel ITRGISHLHTELRL--G--DQHKPCVAHRDINTRNVLVQAD-LSCCIADFGFALKVFGSK TGFBR2_Mmus LARGIAHLHSDHTPC----GRPKMPIVHRDLKSSNILVKND-LTCCLCDFGLSLRLDPTL ACTR2B_Hsap MSRGLSYLHEDVPWCRG--EGHKPSIAHRDFKSKNVLLKSD-LTAVLADFGLAVRFEPGK ACTR2_Hsap MARGLAYLHEDIPGL-K--DGHKPAISHRDIKSKNVLLKNN-LTACIADFGLALKFEAGK TGFbRII_Spur AARGLAHLHAETYGSH---GLHKVPVAHRDLKSTNILVKDD-GSCAIADFGLAIRLDPQS ACTR2_Spur MAKGLAYLHEDIPPTTA-IPFVKHSVAHRDFKSKNVLIKNN-TTACIADFGLACVFEAGK BMPR2_Spur TAAGLAHLHQVIDT--Q--VGLKPAVVHRDINSRNVLVNAE-GNCVIGDFGFAMQVCGSS AqueK683_Aque MSSGLAHLHYMESSQSHS-KYRVITIAHCNINSHNILMKED-GTVFLSDF---------- AqueK684_Aque GAAGLEHLHSVDNC--P--ETYKPAIAHRDLKSKNILVKKD-MTCCISDFGLAIKFDGVD AqueK685_Aque ITSGITHLHSSSYYSN-GLLADKFSIAHRDIKPSNILVKSPSGQCVVADFGQAFVLDPAA AqueK686_Aque IASGITHLHSNSYYNSNGLLLEKYSIAHRDIKPSNILVKSVSGHCVVADLGLAFILDPAA *: .** : * ::.. *:*:. : *: TGFbR2_Hsap S-------VDD-LANSGQVGTARYMAPEVLESRMNLENV-ESFKQTDVYSMALVLWEMTS MISR2_Hsap QPPAWTPTQPQGPAAIMEAGTQRYMAPELLDKTLDLQDWGMALRRADIYSLALLLWEILS MISR2_Mmus QPPALAPTQPRGPAAILEAGTQRYMAPELLDKTLDLQDWGTALQRADVYSLALLLWEILS BMPR2_Mmus LV---RPGEED-NAAISEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEVFM ACTR2B_Mmus ---------PP-GDTHGQVGTRRYMAPEVLEGAINFQR--DAFLRIDMYAMGLVLWELVS ACTR2_Mmus ---------SA-GDTHGQVGTRRYMAPEVLEGAINFQR--DAFLRIDMYAMGLVLWELAS daf-4_Cele ---------EQ-SDLLGQVGTKRYMSPEMLEGATEFTP--TAFKAMDVYSMGLVMWEVIS BMPR2_Hsap LV---RPGEED-NAAISEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFM put_Dmel ---------PC-GDTHGQVGTRRYMAPEVLEGAINFNR--DAFLRIDVYACGLVLWEMVS wit_Dmel YEYKGEVAMAE-TKSINEVGTLRYMAPELLEGAVNLRDCETSLKQMDVYALGLVLWEVAT TGFBR2_Mmus S-------VDD-LANSGQVGTARYMAPEVLESRMNLENV-ESFKQTDVYSMALVLWEMTS ACTR2B_Hsap ---------PP-GDTHGQVGTRRYMAPEVLEGAINFQR--DAFLRIDMYAMGLVLWELVS ACTR2_Hsap ---------SA-GDTHGQVGTRRYMAPEVLEGAINFQR--DAFLRIDMYAMGLVLWELAS TGFbRII_Spur S-------TDH-LANSGQVGTPRYMSPEALECKVNLQDI-ESFKQMDTYALALILWEITS ACTR2_Spur ---------NP-GDTHGQVGTRRYMAPEVLEGAIQFKR--DAFLRIDMYAFGLVLWELVT BMPR2_Spur VV---GEGDGD-NSTITDVGTVRYMSPEVLDGAVNLRDCECALKQVDVYALGLVVWEIAM AqueK683_Aque ------------------------------------------------------------ AqueK684_Aque --------MIL-SEAKGQVGTSRYMAPEILEGAVRFNQ--EAFLKIDIYAFGLILWEM-- AqueK685_Aque D-------DRK-LAVSGQVGTYRYMSPEALDARVNLRDS-ESFKQIDVYAMSLVLWEVCM AqueK686_Aque D-------DRK-LAVSGQVGTYRYMSPEALDARVNLRDI-ESFKQIDMYALSLVLWEVCM TGFbR2_Hsap RCNAV----GEVKDYEPPFGSKVREH-PCVESMKDNVLRDRGRPEIPSFWLNHQ-GIQMV MISR2_Hsap RCPDLR-PDSSPPPFQLAYEAELGNT-PTSDELWALAVQERRRPYIPSTWRCFATDPDGL MISR2_Mmus RCSDLR-PDHRPPPFQLAYEAELGSN-PSACELWALAVEERKRPNIPSTWSCSATDPRGL BMPR2_Mmus RCTDLF-PGESVPDYQMAFQTEVGNH-PTFEDMQVLVSREKQRPKFPEAWKENSLAVRSL ACTR2B_Mmus RCKAA---DGPVDEYMLPFEEEIGQH-PSLEELQEVVVHKKMRPTIKDHWLKHP-GLAQL ACTR2_Mmus RCTAA---DGPVDEYMLPFEEEIGQH-PSLEDMQEVVVHKKKRPVLRDYWQKHA-GMAML daf-4_Cele RTKLH-Q-TDEPPNYQMPFQ-VIGFD-PTIGLMRNYVVSKKERPQWRDEIIKH------- BMPR2_Hsap RCTDLF-PGESVPEYQMAFQTEVGNH-PTFEDMQVLVSREKQRPKFPEAWKENSLAVRSL put_Dmel RCDFA----GPVGEFQLPFEAELGLR-PSLDEVQESVVMKKLRPRLLNSWRAHP-GLNVF wit_Dmel RCSDFYAPGQATPPYKAPYEQEVGSH-PSFDQMQALVVRHKARPLFPTGWGGGA-AAKVV TGFBR2_Mmus RCNAV----GEVKDYEPPFGSKVREH-PCVESMKDSVLRDRGRPEIPSFWLNHQ-GIQIV ACTR2B_Hsap RCKAA---DGPVDEYMLPFEEEIGQH-PSLEELQEVVVHKKMRPTIKDHWLKHP-GLAQL ACTR2_Hsap RCTAA---DGPVDEYMLPFEEEIGQH-PSLEDMQEVVVHKKKRPVLRDYWQKHA-GMAML TGFbRII_Spur RCTLL----KDINEYELPFSRSLGDRRASLEMMKTLVVLRRERPPITDEWLRNP-GLTII ACTR2_Spur RCTVQ---DGPVPEYRLPFEEELGQG-TSLEDMQEWVVVKRKRPVISDHWLKHR-GLELL BMPR2_Spur RCKDLY-PRDEMGNYQMPFEEQVGLH-PTFEDMQILVSRERKRPQFPDAWKQNSQALRSL AqueK683_Aque ------------------------------------------------------------ AqueK684_Aque ------------------------------------------------------------ AqueK685_Aque RYQSN---DVPVPPYQSPFFDMVGEK-PTLDQMKEIVVINKQRPLLPEKWNNDK-NLKRI AqueK686_Aque RYQSD---DVPVPPYQSPFFDMVGEK-PTLEQMKEIVVNANKRPGFTGVWYSDK-NLKRI TGFbR2_Hsap CETLTECWDHDPEARLTAQCVAERFS MISR2_Hsap RELLEDCWDADPEARLTAECVQQR-L MISR2_Mmus RELLEDCWDADPEARLTAECVQQR-L BMPR2_Mmus KETIEDCWDQDAEARLTAQCAEER-M ACTR2B_Mmus CVTIEECWDHDAEARLSAGCVEER-V ACTR2_Mmus CETIEECWDHDAEARLSAGCVGER-I daf-4_Cele ----------------------EY-M BMPR2_Hsap KETIEDCWDQDAEARLTAQCAEER-M put_Dmel CDTMEECWDHDAEARLSSSCV----M wit_Dmel RDTCEDCWDHDADARLTS-------L TGFBR2_Mmus CETLTECWDHDPEARLTAQCVAERFS ACTR2B_Hsap CVTIEECWDHDAEARLSAGCVEER-V ACTR2_Hsap CETIEECWDHDAEARLSAGCVGER-I TGFbRII_Spur KNTVVDCWDEDPEARLT--------A ACTR2_Spur CETIEECWDQDAEARLS--------A BMPR2_Spur KETIEDCWDHDAEARLT--------A AqueK683_Aque -------------------------- AqueK684_Aque -------------------------L AqueK685_Aque IKLIVEGWDEDPEARLTAANIKIQ-L AqueK686_Aque IKLIKEGWDEDPEARLTAANIKIQ-L