CLUSTAL W (1.83) multiple sequence alignment Wee1_Hsap FHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHSH Wee1B_Hsap FLEVEKIGVGEFGTVYKCIKRLDGCVYAIKRSMKTFTELSNENSALHEVYAHAVLGHHPH DDB0220004_Ddis FQELDLIGEGSFGHVYKVRHRIDGCLYAIKKTKKPLKGQKDRDIVLREVYGLSAIKDHTN wee_Dmel FMQVNVIGVGEFGVVFQCVNRLDGCIYAIKKSKKPVAGSSFEKRALNEVWAHAVLGKHDN Wee1a_Spur -------------------------------------DTPFRQMALNEVYAHAVLGTHIH Wee1b_Spur FVEVGKVGSGEFGSVYKCINRLDGCFYAIKKSKRPIAGSAFEQMALNEVYAHAVLGTHIH AqueK218_Aque FHEVCIIGSGSFGVVYKCINRLDGCVYALKRSHKPVVGSADEPAALREVYAHAVLGSHPH Wee1B_Mmus FFEIEKIGVGEFGTVYKCIKRLDGCIYAIKRSAKSFSGLSNE-LDLHEVYAHAVLGHHPH Wee1_Mmus FHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHPH . *.**:. :.: * : Wee1_Hsap VVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLRYIH Wee1B_Hsap VVRYYSSWAEDDHMIIQNEYCNGGSLQAAISENTKSGNHFEEPKLKDILLQISLGLNYIH DDB0220004_Ddis IVRYFNAWEEDSHIFIQMEHCNGGNIYKWVTEHIK----QSESNLLLLAKQILTGIVYIH wee_Dmel VVRYYSAWAEDDHMLIQNEFCDGGSLHARIQDH-----CLGEAELKIVLMHVIEGLRYIH Wee1a_Spur VVRYYSAWSEAGHMIIQNEYCNGGSLADIISSNKQNNHRMTEIELKQVLVQIAQGLKYIH Wee1b_Spur VVRYYSAWSEAGHMIIQNEYCNGGSLADIISSNKQNNHRMTEIELKQVLVQIAQGLKYIH AqueK218_Aque LVRYYSAWAEDDHMLIQNEYCNGGTLSSLISKIHKSTLRFNEVQLNRLIQHLAMGLTYIH Wee1B_Mmus VVRYYSSWIEDDHVVIQNEYCNGGSLQAAISENTASNNHFQEPKLKDILLQISLGLKYIH Wee1_Mmus VVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRVMSYLTEVELKDLLLQVGRGLRYIH :***:.:* * .*:.** *.*:**.: : . * :* : :: *: *** Wee1_Hsap SMSLVHMDIKPSNIFISRTSIPNA-------------------------ASEEGDEDD-- Wee1B_Hsap NSSMVHLDIKPSNIFICHKMQSESSGV----------------------IEEVENEAD-- DDB0220004_Ddis SLGLVHLDIKPENIYIIYKCNQNQIITNNNNTCSINNSSNGSDSYFKSKIKTTENDLDNF wee_Dmel SNDLVHMDLKPENIFSTMNPNAHKLVE----------------------VQPQQTKDDDG Wee1a_Spur SEGLVHMDIKPGDL---------------------------------------------- Wee1b_Spur SEGLVHMDIKPGNI---------------------------------------------- AqueK218_Aque SMGLVHLDIKPENVFISLPTLPDSRLP----------------------PQAEV-SWD-- Wee1B_Mmus NSGMVHLDIKPSNIFICHKMQCDSPVG----------------------PEEAESEAD-- Wee1_Mmus SMSLVHMDIKPSNIFISRTSIPNA-------------------------VSEEGDEDD-- . .:**:*:** :: Wee1_Hsap -------------------------------------W-ASNKVMFKIGDLGHVTRISSP Wee1B_Hsap -------------------------------------WFLSANVMYKIGDLGHATSINKP DDB0220004_Ddis ITTTNSVNNNNCNNNNNNNVDNQNNNNQNNYLIIDGNKINFNSITFKIGDLGLLNEATNT wee_Dmel MDS-----------------------------VYEELRHSENLVTYKIGDLGHVTSVKEP Wee1a_Spur ---------------------------------------------------GHVTSISNP Wee1b_Spur ---------------------------------------------------F-------- AqueK218_Aque -------------------------------------SLLMSEALYKIGDMGHVTSVKSP Wee1B_Mmus -------------------------------------WFLNASVMYKIGDLGHATSISKP Wee1_Mmus -------------------------------------W-ISNKVMFKIGDLGHVTRISSP Wee1_Hsap QV-EEGDSRFLANEVLQENYTHLPKADIFALALTVVCAAGAEPLPRNGDQWHEIRQGRLP Wee1B_Hsap KV-EEGDSRFLANEILQEDYRHLPKADIFALGLTIAVAAGAESLPTNGAAWHHIRKGNFP DDB0220004_Ddis KIYSEGDSRYLSRELLHDDMSALKKSDIFSLGCTLYELARCKPLPKSGMEWDSIRNGILS wee_Dmel YV-EEGDCRYLPKEILHEDYSNLFKADIFSLGITLFEAAGGGPLPKNGPEWHNLRDGKVP Wee1a_Spur KV-EEGDVRFLPVEILQEEHTHLTKADIFALALTAYLAAGGESLPKNGDDWHRIRQGHFP Wee1b_Spur ------------------------------------------------------------ AqueK218_Aque QV-EDGDCRFISREVLQEDYSSLLESDVFSLGLTVYCAGSLCDLPKNGPEWHRIRDGHLP Wee1B_Mmus KV-EEGDTRFLANEILQENYQHLPKADIFALGLTIAVAAGAESLPINGDMWHHIRKGNFP Wee1_Mmus QV-EEGDSRFLANEVLQENYSHLPKADIFALALTVVCAAGAEPLPRNGEQWHEIRQGRLP Wee1_Hsap RI---------PQVLSQEFTELLKVMIHPDPERRPSAMALVKHSVL Wee1B_Hsap DV---------PQELSESFSSLLKNMIQPDAEQRPSAAALARNTVL DDB0220004_Ddis FEKEDSIYDDNKNDFSTEFWQLIKSMIHPDPSVRPSAEQLLEHPLI wee_Dmel IL---------PS-LSRDFNELIAQMMHPYPDKRPTSQSIFSHPIL Wee1a_Spur PL---------LH-ISTDLVDLLQTMIDPDPSQRPSASALVQHPLL Wee1b_Spur ------------------------------------------ISKK AqueK218_Aque AL---------SQ-CSEHFNKLLLSLVHSSPSKRPTASELQSHPIV Wee1B_Mmus EI---------SQELSDDFYGLLKNMIHPAPKERPSAAALARSRIL Wee1_Mmus RI---------PQVLSQEVTELLRVMIHPDPERRPSAMELVKHSVL