CLUSTAL W (1.83) multiple sequence alignment ADCK2_Mmus MVTPWRLSV-R---VCLSHLR-----CFEF-----R-K-------------ELGHSRPLG Y32H12A.7_Cele MIFGSTRLILY---RCWAHSR-----AVSS-----R-NFKLGIVLGMGGAVSLTRLRTLK YPL109C_Scer MGLYVSSEN-E---LQ----------------------------------EKLKSFRSAK ADCK2_Hsap MVAPWRVSV-R---VCLSHLR-----CFEL-----R-Q-------------GLSLLRPSE AdckC_Ddis MSNKQIFLKFKSGEIILNNFN-----KYTD---SIS--------------SKLLFYQNIK ADCK2_Spur MFIHHISRI-T---LQLRRVR-----PLH------------------------------- CC1G_01824_Ccin ------------------------------------------------------------ AqueK030_Aque MVGTSCSAVIG---S----------------------------------MLILNNNRSVH ABC1-C-1_Smoe MLFFGRTLS-N---SSFSRIGYGHHHYGTLSQEAAASP-----------LQVLSRNLARH ABC1-C-2_Smoe MA---------------------------------------------------------- ADCK2_Mmus -----------------------------------------------------------C Y32H12A.7_Cele -----------------------------------------------------------C YPL109C_Scer -----------------------------------------------------------I ADCK2_Hsap -----------------------------------------------------------C AdckC_Ddis NQENNSGN------------------ENYKNFNYNYKNKNNYNNNNNNNNSNSSSNNNGS ADCK2_Spur ------------------------------------------------------------ CC1G_01824_Ccin ------------------------------------------------------------ AqueK030_Aque -----------------------------------------------------------C ABC1-C-1_Smoe -----GGNRIVFGFSRTGVEFKDGWKK---------------------KGTGFAGWKLGS ABC1-C-2_Smoe ------------------------------------------------------------ ADCK2_Mmus SRNA-------------RLCWFLLGTLPKL---------------I--------SAHGSV Y32H12A.7_Cele EAEH-------------QDPWLLVPQK--------------------------------- YPL109C_Scer TE---------------------------------------------------------- ADCK2_Hsap PRDA-------------RLCWLLLGTLPKV---------------V--------SLCGDV AdckC_Ddis NNNI-------------KFNSLFISSIYLYNNNNSNNNDLKNDKN-------------DN ADCK2_Spur --------------------WTVLKRLPQP-----KYHPTKSVALT--------VCCAFI CC1G_01824_Ccin ------------------------------------------------------------ AqueK030_Aque IES--------------------------------------------------------- ABC1-C-1_Smoe STGRAWKNSWLGRCYYHHPLWKVVGTMSLA---------------VVRSQFSPRIAAFLV ABC1-C-2_Smoe ------------------------------------------------------------ ADCK2_Mmus GEGA----PGSLCQRKTHWSDLAENGLV------EKVAQ---------------E-GPLA Y32H12A.7_Cele -----------------------------------KVVVEKSTMMGIITLP--IT--LIV YPL109C_Scer ---------------------------------------SRNKLIRYLRIFW---FGFND ADCK2_Hsap GEGA----PDVLSRRRVRCSGAAGAGPA------ESLPR---------------A-GPLG AdckC_Ddis SIGN----INKIIKPKIEIQD----------------------LLNPFEAIKEIVGNKED ADCK2_Spur GVASYKRLPQILFS-RAACQEAVLDHPVLINSEIDRLHSVKSLLVGQMRLWHHVLRTLAS CC1G_01824_Ccin ------------------------------------------------------------ AqueK030_Aque -------------------------------------------KSGFIDKP--IV--IPD ABC1-C-1_Smoe GEA-------TLMRRLVAESEAPTCVPL-----------SYHSDIQPS----YV-LWIFS ABC1-C-2_Smoe ------------------------------------------------------------ ADCK2_Mmus RVLLCLRLGLRAGVLLAKFFPLLFLYPLTYLAP------------GLSTLWLHLLFKATE Y32H12A.7_Cele VTYKAIRKMFRCISLFLRFSPILLTYPLTKIE-------------AFENLWWRYLLWSLQ YPL109C_Scer NIVEPVCTILRFLEISAIFLPLLLLYPISWFGHKLKITDTNITETRGSLIWCQLLRKALE ADCK2_Hsap GVFLHLRLWLRAGALLVKFFPLLLLYPLTYLAP------------SVSTLWLHLLLKATE AdckC_Ddis EEINLVKIGIRVLELGLILLPSVLTFPCCFI-P------------GVKELWWQLLLETIQ ADCK2_Spur NLVQFVLVSLRYIRNSILFGPLLFSYPLVLLFPD-----------RLQDVWLRALLRSIE CC1G_01824_Ccin ----------------------------------------------------------ME AqueK030_Aque GSFNRLIVVFRLFYLGLLFSPVLLCHVIEILLPL---------R-FILSLKWSLLLFSIE ABC1-C-1_Smoe SLVEGMMLLLRALYLVVVFAPALAVAPFADPS-----------DAKLRLFWLELFHSSLE ABC1-C-2_Smoe KTVEAVLLFFRTLYLFALFTPALVLSMFAADKP----------DSRLRAAWLYVLLRTLE : ADCK2_Mmus TSGPTYIKLGQWASTRRDLFSEAFCTQFSKLHVQVTPHPWAR-TEYLLQQAF-GE-DW-- Y32H12A.7_Cele HSGPTFIKLGQWASTRRDIFTKKFCDRLSVLHIQTKNKRFFRDKKKVMNEVF-GK-GFMK YPL109C_Scer LAGPSFIKLGQWAGSRTDIFSHALCHELGKLHSNVTAHSLSF-TLEKLSQAL-KVDKI-- ADCK2_Hsap TSGPTYIKLGQWASTRRDLFSEAFCAQFSKLHVRVTPHPWTH-TERFLRQAF-GD-DW-- AdckC_Ddis FSGTCWIKFGQWISTRPDLFPDLLIEKFSQLHSQCPSHSFQF-TNESIENSFNGK-SI-- ADCK2_Spur LSGPTFIKLGQWASTRRDLFSQDFCDQLSKLHRNAPSHSVEY-TKRALEHAF-GL-LG-- CC1G_01824_Ccin AAGPTFIKLAQWAASRVDLFPPILCERLGALHSQGTPHPFSH-TKKVVEAVF-QR-PF-- AqueK030_Aque RAGPAFIKLGQWASTRPDIFSESTCAFLSQLQRDCTPHSWDA-TKQTLEDSF-GP-QW-- ABC1-C-1_Smoe RAGAAFIKWGQWAATRPDLFPKDVCETMSKLHSKAPAHSFSQ-TRKTVEGAF-GK-RI-- ABC1-C-2_Smoe YAGPAFIKWGQWAATRPDMFPADICQQLSKLHSQAPAHTFYE-TRKIIEKAF-HL-PL-- :*. :** .** .:* *:*. :. *: : . : : ADCK2_Mmus ---GSLLFF-ETREPVGSGCVAQVYKAFASISLLEEDRIWRLGELS--APG--TRAVVMQ Y32H12A.7_Cele LHGKQVFL-EIEPFSIGSGCIAQVYRGTVDISELEKATGKEY------------------ YPL109C_Scer ---EDAFD-EFNRTPIGVGSIAQVYVGELSQKYIDKYDNIQ------------------- ADCK2_Hsap ---GSILSF-ENREPVGSGCVAQVYKAYANTAFLETDSVQRLGRASCLPPFSHTGAVGGL AdckC_Ddis ---KDLFL-WFDEEPMASGSVAQVHKALTM-D---------------------------- ADCK2_Spur ---KEIFRLESGNETVYSGCVGQVHKAYMRPDVYQAVM---KGR------------EGGL CC1G_01824_Ccin ---DQVFE-EFDQTPIGSGAIAQVYRATLKRDLIPPSYHGPR---R-------TRQVGG- AqueK030_Aque ---EDMFT-RYDHTPIGSGCIAQVYKWDLSTDSMQCSADAAV------------------ ABC1-C-1_Smoe ---EELFE-DFEEEPLASGSVAQVHRAVLRGQ---------------------------- ABC1-C-2_Smoe ---DRLFE-EFSEKPIASGSIAQVHKAVLRTK---------------------------- : .: *.:.**: ADCK2_Mmus REPF---MKDRKPSENLADEAFLEKLLLPKADLGGSEVGVS--QAPW---HLPKSDHLIP Y32H12A.7_Cele ---------------------------------------------P-----ELKGRTTQR YPL109C_Scer ----------------------------------------------------IGKDGNRW ADCK2_Hsap RELFGYLGNGRKPPENLADQSFLERLLLPKADLVGSNAGVSRAQVPG---HQPEATNLIS AdckC_Ddis --------------------------------------------------------G-KV ADCK2_Spur RDWR---MRD-------------------------------RASDP-----IMDEEKWIP CC1G_01824_Ccin ------------------------------------------ALGPIILEDPPPSAPTAS AqueK030_Aque ----------------------------------------------------KANGGSLP ABC1-C-1_Smoe ------------------------------------------------------GKKPVT ABC1-C-2_Smoe ------------------------------------------------------GQKPLV ADCK2_Mmus VAVKVLHPGLLSQVSMDLLLMKIGSKALG-LLPGVKWLSLPEIVEEFEKLMVQQTDLRYE Y32H12A.7_Cele IAIKVADKDVDKQIELDLSILRSGAWLMQHIVPALWYLDPTGALEQFEMVLRRQVDLRNE YPL109C_Scer CAIKILHPNVRSQIRRDLKIMKFCADAIN-WIPTMEWLSLPSEVDQFSILMNIQLDLRIE ADCK2_Hsap VAVKVLHPGLLAQVHMDLLLMKIGSRVLG-VLPGIKWLSLPEIVEEFEKLMVQQIDLRYE AdckC_Ddis AVVKVLHPNVKSNIKRDFFIIYSLIWAFS-HIPEMKWLSLPESILEFGKSMMKQADLELE ADCK2_Spur VAVKVLHPGIYESVHLDLRIINVFARILN-LIPGLHWLSPVDLVDEFESLMKNQINLKLE CC1G_01824_Ccin VAIKILHPRVEKTISRDLAIMHFFASCIS-LLPGMKWLSLPEEVLVFGEMMNQQLDLRHE AqueK030_Aque VAVKVVHPGVVGSVLRDVYLMETVAWFVDRVFPSVYWISLRECVDEFGIVMKKQLDLKAE ABC1-C-1_Smoe VAVKVRHPGVTEVIRRDFILINWVVKACS-HFSGLRYLRLEDSVQQFAVFMLTQVDLARE ABC1-C-2_Smoe VAVKVRHPRVSTVIQRDFVIMNWLARMST-KFSSLEHLQLDKTVQQFATFMTKQVDLTLE .:*: . : : *. :: .. : : : * : * :* * ADCK2_Mmus AQNLEHFQHNFQDMA-SVKFPTPLRPLITRDILVETYEESVPVSSYQQAG---------- Y32H12A.7_Cele AKALKKFSDNFSSKETGIKFP--IVLGYTKNVIVETFEEGIYINRLVAEEGQPEIFENET YPL109C_Scer ALNLERFNENFKNSI-QVKFPKPFLPLSNRDVMFEEHVYGLSMEKFLSTKKQIN------ ADCK2_Hsap AQNLEHFQVNFRNVK-AVKFPTPLRPFVTREVLVETYEESVPVSSYQQAG---------- AdckC_Ddis ASHLNRFNSNFKYNS-EVIFPKPLYPLVSKEVLVESFEPGSPIMDFIKKND--------- ADCK2_Spur AENLERFHQNFSKVP-HVRIPQPVWPFVTNEILVETFESGQSISAFISCDPDNP------ CC1G_01824_Ccin ADNLITFEANFAPRKVPVTFPRPLKIWSSKDILVEEYQNALPLETFLRNGGG-------- AqueK030_Aque AVSMDQFRKNFKSHK-HIKIPQPIHTLVTNSVLVETFEEGVHISQYVKESEQ-------- ABC1-C-1_Smoe AAHLSRFLYNFRSWK-DVSFPKPLYPLVHPAVLVETYERGESVSRFVDSPKR-------- ABC1-C-2_Smoe AAHLMRFIYNFRQWR-NVSFPRPIYPLVHPEVLVETFEEGRSIQEFIDEGPR-------- * : * ** : :* . ::.* . . : ADCK2_Mmus ------------------IPTDLKRKIAQLGINMLLKMIFVDNFVHGDLHPGNILVQGAD Y32H12A.7_Cele FFRYLFLKIIDFEMLTARQSQAVRRRIALLGARALLKMIFVDNFVHGDLHPGNILIRFND YPL109C_Scer -------------------DVELCKKVSDPFVDAFLQMLILDDFVHADLHPGNVIIRFVK ADCK2_Hsap ------------------IPVDLKRKIARLGINMLLKMIFVDNFVHADLHPGNILVQGAN AdckC_Ddis -------------------H--HNPTLAKIGLSAYMQMMLVDNFVHADLHPGNVLVRTSD ADCK2_Spur ------------------DEKGIKKILAQMGVDVILKMVFVDNFVHADLHPGNILVQGVE CC1G_01824_Ccin -------------------P--YDYQIATVGLNAFLTMLLLDNFVHSDLHPGNIMIKFSK AqueK030_Aque --------------------TSLKKRIASLGIDVLLNMLFVHNFVHCDMHPGNLLVQTDP ABC1-C-1_Smoe --------------------SHINSALAHIGTHTLLKMLLVDNFIHADLHPGNILVRMER ABC1-C-2_Smoe --------------------TKLHSQLARLGSSLLLKMLLSDNFIHGDLHPGNMFVKLGK :: : *:: .:*:* *:****:::: ADCK2_Mmus GVS-PSLEMQ----------QQQVN-----------------VCDTL---------VAT- Y32H12A.7_Cele NEDNLRGVHK----------APKAD--SALKRG-LE------WFRSLVNLRSAPRIRFT- YPL109C_Scer TNKYGTNIIS--------SELESYRITHDLRKK-IE----EDQDQDF---------VGK- ADCK2_Hsap GLS-SSQEAQ----------LQQAD-----------------ICDTL---------VVA- AdckC_Ddis DDNF-KSIDNNYFKKYNNDN-DQQQ--QQ----QYNLPFKRKLYDTI---------EKSH ADCK2_Spur EAL-VQPSRT----------VDFHD-----------------HITEF---------QVY- CC1G_01824_Ccin PPTT-RILLQNLYNHFFPSSVDQST--SDVSSASLMIPADYSQSDEI---------VARL AqueK030_Aque SVG--------------------------------------------------------- ABC1-C-1_Smoe FNPVPGK----------------------------------------------------- ABC1-C-2_Smoe ------------------------------------------------------------ ADCK2_Mmus -----------------IAPALCPLRLVLLDAGIVAKLQASDLRNFRAVFQAVVMGQGHR Y32H12A.7_Cele ----------------DSPDLEDEPTLVLLDTGIAISETPKNLHNLKSLFRSVVEKRGYD YPL109C_Scer --------------L-KSVLTNYTPQICFIDTGIITELNEKNRINFIALFNALARFDGYR ADCK2_Hsap -----------------VPSSLCPLRLVLLDAGIVAELQAPDLRNFRAVFMAVVMGQGQR AdckC_Ddis KKFDSMLGGIQLKSIDFKEHQKSSPKLIFLDVGLVTQLGQQDKDHFIELFTEIVNGNGKE ADCK2_Spur -----------------LKEPKNPIKLVLLDTGITSHLEERDFNNFYKVFTAIVLRKGDV CC1G_01824_Ccin RKVSNSPDEWS-RELLKLHSGGYVPEIVFIDAGLVTTLNDTNRTNFLDLFKAVAEFDGYK AqueK030_Aque --------------------GGGDPSLVLLDCGVTASLNNRDWDNLHQLFLAIVKKEVRD ABC1-C-1_Smoe ------------------GLFRSHPHLVFLDVGMTAELSNKDRRTLLEFFKGIAMRDGRK ABC1-C-2_Smoe ----------------------KVPQLILLDVGMTAELSQRNRYILLELFKALSDKDGAR : ::* *: : : .* : ADCK2_Mmus VAELMLHHAQANE-CKDVER--FKAEMATLVTQARKNIVTLEKLHVSSLLSSVFKLLMTH Y32H12A.7_Cele VGKLLLHQSPFQQ-CNDPER--FCRQVEKLVLKARS-EKSLRTLNISALLSEMFTIVAEH YPL109C_Scer AGELMIERSRTPETAIDKEV--FAFKVEKLVDKVKQRTFTLGTVSIGDLLDQMLSMVRSH ADCK2_Hsap VAELILHHARASE-CRDVEG--FKTEMAMLVTQARKNTITLEKLHVSSLLSSVFKLLMTH AdckC_Ddis GAELLIRYAREAK-CTEEEMYQFKERMGTLFNQV--QNSKLSEVHVGQFMSEILGLVREY ADCK2_Spur VAELFAEHASSNE-CNDVEK--FKADMKSLVEKAHERSLQLSKMQVGQLLRELFALMIHH CC1G_01824_Ccin TGQLMIERSRTPELAVDKET--FALKMQHLILSIKRKTFSLGQIKIADLLTDVLKNVRKH AqueK030_Aque ISHAFMH----------------------------------------------------- ABC1-C-1_Smoe TAECALQFSELQT-CPDPKG--FVREVEDCFKDW--NAMDSAVLHTGDCIQELLERVRRH ABC1-C-2_Smoe VARCALEFSEDQT-CTNPEA--FIGDVDNTFKQY--LS-VRGTSKMGDYIAELFEQVRRY .. . ADCK2_Mmus KVKLESNFASIVVAIMVLEGLGRSLDPTLDILEAAKPFLFKGP----------------- Y32H12A.7_Cele KVELDSAFTTVILSVMVLEGFGRSLDPDLDLFQCARPFLLN------------------- YPL109C_Scer HVRMESDFVSVVVAILLLEGIGRQLDPNLDLFERFVFYAWI-N----------------- ADCK2_Hsap KVKLESNFASIVFAIMVLEGLGRSLDPKLDILEAARPFLLTGP----------------- AdckC_Ddis HVKIESNFATLVMGTIVLEGLGKQLDPSLGLLKAAIPFLLKSQVFS-------------- ADCK2_Spur KVKLESNFASIILAIMVLEGLGRSLDPNLDILKAAKPVLL-------------------- CC1G_01824_Ccin RVKMEPDFINTVISILLLEGIGRQLDPKMDLFASALPILRQLGGQMAMDTKVEGLPSAKD AqueK030_Aque ----------LIFVIVYVD--------------------VP------------------- ABC1-C-1_Smoe KVNIDGDVCTVIVTTLVLEGWQRKLDPEYNIMETLQSLVLQSNMAS-------------- ABC1-C-2_Smoe RVNLDGEVCTVMVTVVILEGWQRKLDMSLDIMRMVKELLFKAEWTA-------------- :. : :: ADCK2_Mmus ------------------------------------------------------------ Y32H12A.7_Cele ------------------------------------------------------------ YPL109C_Scer ------------------------------------------------------------ ADCK2_Hsap ------------------------------------------------------------ AdckC_Ddis -----------------FSNFIKDFFLKS--KTSKKQLNNDNNNNNNNNNNNKNNNDNNN ADCK2_Spur ------------------------------------------------------------ CC1G_01824_Ccin LPTSDLAALLKVWVWIEARSFISGALVDMDALI--------------------------- AqueK030_Aque ------------------------------------------------------------ ABC1-C-1_Smoe -----------------SLSYTID------------------------------------ ABC1-C-2_Smoe -----------------SFEYVMG------------------------------------ ADCK2_Mmus ---------ASFL Y32H12A.7_Cele ----------VLV YPL109C_Scer ---------GFKE ADCK2_Hsap ---------VCPP AdckC_Ddis KNNNNKNNNEKNK ADCK2_Spur -----------GR CC1G_01824_Ccin ----QRDWLTPNI AqueK030_Aque ----------TKI ABC1-C-1_Smoe --------SIMAP ABC1-C-2_Smoe --------AIAAP