CLUSTAL W (1.83) multiple sequence alignment nsy-1_Cele MSQNNKRQVQ-------------------------H--NHEMSNDVCPLPLPPRGAPPPT Pk92B_Dmel MDTAVGDH---------------------------------------------------- MAP3K5_Mmus MGTEAGEGITFSVPPFASVGFCTIPEGGSCRRGGGAATAAEGEPSLQPLLVPP-PPPPPG MAP3K6_Mmus MAGPC-------------------------PGAGVLERAG-------------------- MAP3K7_Mmus MEGGGGSGG----------------GGGPVPAEAP-EEAG--EPPQ--------GRLPPG MAP3K7_Hsap MESGGGNA----------------------PAGAL-GAAS--ESPQ--------CPPPPG MAP3K5_Hsap MSTEADEGITFSVPPFAPSGFCTIPEGGICRRGGAA-AVGEGEEHQ------L-PPPPPG MAP3K6_Hsap MAGPC-------------------------PRSGA-ERAG-------------------- ASK_Spur ------------------------------------------------------------ AqueK224_Aque MSSKVKLQ---------------------------------------------------- nsy-1_Cele AYHA----SR------MAATSSSTNGSFEKSAIP--GNARKLHVVIVIDQKVQKNLRV-- Pk92B_Dmel ------------------------------------------------------------ MAP3K5_Mmus SFWNVESAAAPGTSCPT-TAPGSSATRGRGNSGS--GGGRRTTVAYVINEASQGQLVV-- MAP3K6_Mmus SCWQDP----------L-AEALSRGRSSPAVTGRGCARSRPLSVVYVLTREPGLGVEPGS MAP3K7_Mmus ----PEGAAGL--AEPE-STGDAA--GGEAEGGR--GPRRALRAVYVRSESSQGAAAG-G MAP3K7_Hsap ----VEGAAGP--AEPDGAAEGAAGGSGEGESGG--GPRRALRAVYVRSESSQGGAAG-- MAP3K5_Hsap SFWNVESAAAPGIGCPA-ATSSSSATRGRGSSVG--GGSRRTTVAYVINEASQGQLVV-- MAP3K6_Hsap SCWQDP----------L-AVALSRGRQLAAPPGRGCARSRPLSVVYVLTREPQPGLEPRE ASK_Spur ------------------------------------------------------------ AqueK224_Aque ---------------------------------RS--VREQQVIVTVIPDT--------- nsy-1_Cele ----REMALKDVQKVADTL-----NVNLTRIDFDKLDFGETETLDLFYNADVALVDVTVT Pk92B_Dmel -LEDRQCALEEIKQAVQSA-----GANFQRVQFERLDFGETNVLETFYNADVAIIDLSIL MAP3K5_Mmus ---AESEALQSLREACEAV-----GATLETLHFGKLDFGETAVLDRFYNADIAVVEMSDA MAP3K6_Mmus GTEAEPLPLRCLREACAQLQGTRPPPQLRSLPFATLALGDTAALDSFYNADVVVLEVSSS MAP3K7_Mmus --GPEAGALKCLLRACEAE-----GAHLTSVPFGELDFGETAVLDAFYDADVAIVDMSDI MAP3K7_Hsap --GPEAGARQCLLRACEAE-----GAHLTSVPFGELDFGETAVLDAFYDADVAVVDMSDV MAP3K5_Hsap ---AESEALQSLREACETV-----GATLETLHFGKLDFGETTVLDRFYNADIAVVEMSDA MAP3K6_Hsap GTEAEPLPLRCLREACAQVPRPRPPPQLRSLPFGTLELGDTAALDAFYNADVVVLEVSSS ASK_Spur -------AEDALNNACRLVN----NVTLIKVNFDRLDFGETKVLDRFYAADIVVVDVSVI AqueK224_Aque -REGRK-CFNVLQEVANEL-----DYIVERIAFEKLDFGETDALDKFYSSNVAVADVTDR : .. . : * * :*:* .*: ** :::.: ::: nsy-1_Cele HQQPSLCYHIGVRESMGQSYNMILTYWSPDPEYHIMDALKK--------THAHLPMIVYI Pk92B_Dmel TQQRPLSYHYGVRESFGMKENILTYNDIDSKQ-T--LS-----LK---LSCANYLFLSYK MAP3K5_Mmus FRQPSLFYHLGVRESFSMANNIILYCDTNSDS-L--QSLKEIICQKNTVCTGNYTFIPYM MAP3K6_Mmus LAQPSLFYHLGVRESFSMTNNVLLCSQAELPD-L--QALREDVFQKNSDCVGSYTLIPYV MAP3K7_Mmus SRQPSLFYHLGVRESFDMANNVILYYDTDADT-A--LSLKDMVTQKNTASSGNYYFIPYT MAP3K7_Hsap SRQPSLFYHLGVRESFDMANNVILYHDTDADT-A--LSLKDMVTQKNTASSGNYYFIPYI MAP3K5_Hsap FRQPSLFYHLGVRESFSMANNIILYCDTNSDS-L--QSLKEIICQKNTMCTGNYTFVPYM MAP3K6_Hsap LVQPSLFYHLGVRESFSMTNNVLLCSQADLPD-L--QALREDVFQKNSDCVGSYTLIPYV ASK_Spur VQQRTLFYHMGVRESFGKEKNVVLYNDSVDPEGT--SSLMQ------SCHGSGYIFIPYK AqueK224_Aque ACQAKLFYHLGLRESFEMKQNIVTYLESGASG-G--LR--GGAFN---PKLTSYIYLPYS * * ** *:***: *:: : * nsy-1_Cele HHQDSNQLQSY--DKNNNDDDSKPPFARTNVPAKTITFQHRMKQVLKSVQVEASAHSREK Pk92B_Dmel RNAETNSCHLTSQP-NS-GNNSKEPNAE----GRVPTLQWRLKRKLQDVEIQSKAHMREK MAP3K5_Mmus VTPHNKVYCCDSSFMKGLTEL-MQPNFELLLGPICLPLVDRFVQLLKVAQASSSQYFRES MAP3K6_Mmus VTATGRVLCGDAGLLRGIADGLVQAGAG--TEALLTPLVGRLVRLLEATPTDSCGYFRET MAP3K7_Mmus VTPCADYFCCESDAQRRASEY-MQPNWDTILGPLCMPLVDRFTSLLKDIRVTSCAYYKET MAP3K7_Hsap VTPCADYFCCESDAQRRASEY-MQPNWDNILGPLCMPLVDRFISLLKDIHVTSCVYYKET MAP3K5_Hsap ITPHNKVYCCDSSFMKGLTEL-MQPNFELLLGPICLPLVDRFIQLLKVAQASSSQYFRES MAP3K6_Hsap VTATGRVLCGDAGLLRGLADGLVQAGVG--TEALLTPLVGRLARLLEATPTDSCGYFRET ASK_Spur MDSKSQCYVCDMACVFKAGQL-CEED-----SALCPLLTDRLRETIEEVHISNRSNATEV AqueK224_Aque VDSDGKCLVLDGKN----GDG-FKPK------GSNMSLEVKFRTLLRDMETQYKKQHKEQ : : :: :. * nsy-1_Cele FMSDLRKAREIT--DGDQKNDYLDKMRTRLDN-PDVLHPDTVSLMMLSYRDNQNYGGMIR Pk92B_Dmel FLSDMRTARDTYATNGAKLQSILHEMRKRLDD-PHVLSGEVVHSFMCSLRDVQDYDAMVR MAP3K5_Mmus ILSDIRKARNLY--TGKELAAELARIRQRVDN-IEVLTADIVINLLLSYRDIQDYDSIVK MAP3K6_Mmus IRQDIRQARERF--SGQQLRQELARLQRRLDS-VELLSPDIVMNLLLSYRDVQDYSAIIE MAP3K7_Mmus LLNDIRKAREKY--QGDELAKELTRIKFRMDN-IEVLTSDIIINLLLSYRDIQDYDAMVK MAP3K7_Hsap LLNDIRKAREKY--QGEELAKELARIKLRMDN-TEVLTSDIIINLLLSYRDIQDYDAMVK MAP3K5_Hsap ILNDIRKARNLY--TGKELAAELARIRQRVDN-IEVLTADIVINLLLSYRDIQDYDSIVK MAP3K6_Hsap IRRDIRQARERF--SGPQLRQELARLQRRLDS-VELLSPDIIMNLLLSYRDVQDYSAIIE ASK_Spur LLNDIRKARIKL--KGETLAKELGNLKARMDE-QLLLSGDIVHQFLLSYREIQDYNSMVS AqueK224_Aque FLRQLRKARESL--KGSELKEELLRLQSWIDEDPRLFTADILLSLLLSYRDIQAYENMVL : ::* ** * * .:: :*. :: : : :: * *: * * :: nsy-1_Cele LVDDLKRIPDCLKVVDTPVIRYQYAFALNRRNKDGDRDLALNTVLSLVEGTTENEEKNGP Pk92B_Dmel LVNDLKNIPNTRKYVETGNMSFLYAFALNRRNRKGDREKALESSLKALEK-------KEN MAP3K5_Mmus LVETLEKLPTF-DLASHHHVKFHYAFALNRRNLPGDRAKALDIMIPMVQS-------EEQ MAP3K6_Mmus LVETLQALPTC-DVAEQHNVCFHYTFALNRRNRPGDREKALAVLLPLVKY-------EGP MAP3K7_Mmus LVETLKMLPTC-DLADQHNIKFHYAFALNRRNSTGDREKALQVMLQVLQS-------CDH MAP3K7_Hsap LVETLEMLPTC-DLADQHNIKFHYAFALNRRNSTGDREKALQIMLQVLQS-------CDH MAP3K5_Hsap LVETLEKLPTF-DLASHHHVKFHYAFALNRRNLPGDRAKALDIMIPMVQS-------EGQ MAP3K6_Hsap LVETLQALPTC-DVAEQHNVCFHYTFALNRRNRPGDRAKALSVLLPLVQL-------EGS ASK_Spur LVEAIKQLKND-HVTDKPAILHLYAFALNRRKKPGDREKAVTVITKALES-------DDN AqueK224_Aque LAE---KLPSH-EQALKAPVQVQYAFALNRRNKEGDRDHALSVLEKLLEV-------KEN *.: : . . : *:******: *** *: :: nsy-1_Cele LSPDVVCLAGRIYKDKFIASNYEDRESLNSAIEWYRRAFEMSPLEYSGINLTTLLRASGE Pk92B_Dmel HFPDMLCLCGRIYKDIFVESDYTDATSLAHAIKWYRQSFEVQPNEYAGINLATLLVIEGK MAP3K5_Mmus VASDMYCLVGRIYKDMFLDSNFTDTESRDHGASWFKKAFESEPTLQSGINYAVLLLAAGH MAP3K6_Mmus VAPDLYCMCGRIYKDMFFTSGFQNAGHLEQAYHWYRKAFDVEPSLHSGINAAVLLIAAGQ MAP3K7_Mmus PAPDMFCLCGRIYKDIFLDSGCEEDASRDSAIEWYRKGFELQSSLYSGINLAVLLIVSGQ MAP3K7_Hsap PGPDMFCLCGRIYKDIFLDSDCKDDTSRDSAIEWYRKGFELQSSLYSGINLAVLLIVAGQ MAP3K5_Hsap VASDMYCLVGRIYKDMFLDSNFTDTESRDHGASWFKKAFESEPTLQSGINYAVLLLAAGH MAP3K6_Hsap VAPDLYCMCGRIYKDMFFSSGFQDAGHREQAYHWYRKAFDVEPSLHSGINAAVLLIAAGQ ASK_Spur QVPDMFCLCGRIYKDIYTESNYLDFESRDNAIYWYRKGFEVQPNEYAGINLATLLVLAGK AqueK224_Aque HEPDTLCLCGRIYKDKFVESGHTDTGSRDKAILWYRKGFDIQPNEYAGINLATLLVVSGE .* *: ****** : *. : . *:::.*: .. :*** :.** *. nsy-1_Cele HFENNLEMQQIAVVLNSLLGRKGALQNLMEYWDVATYFEVSVLAENYQKACEAALMMVKL Pk92B_Dmel EFTNTEELQHIGMTLNNLIGKKGSLSSLSEYWDVATFFEISVLANDYAKAIQAAECMFKL MAP3K5_Mmus QFESSFELRKVGVKLSSLLGKKGNLEKLQSYWEVGFFLGASVLANDHLRVIQASEKLFRL MAP3K6_Mmus HFEDSEELRLIGMKLACLLARKGCVEKMQYYWDVGFYLGAQILANDPIQVVLAAEQLYKL MAP3K7_Mmus QFETSMELRKIGVRLNSLLGRKGSLEKMNNYWDVGQFFTVSMLASDIGKAVQAAERLFKL MAP3K7_Hsap QFETSLELRKIGVRLNSLLGRKGSLEKMNNYWDVGQFFSVSMLAHDVGKAVQAAERLFKL MAP3K5_Hsap QFESSFELRKVGVKLSSLLGKKGNLEKLQSYWEVGFFLGASVLANDHMRVIQASEKLFKL MAP3K6_Hsap HFEDSKELRLIGMKLGCLLARKGCVEKMQYYWDVGFYLGAQILANDPTQVVLAAEQLYKL ASK_Spur EFTKCAELQKIGMTLNNLLGKKGSLVSLEDYWDVATFFEISVLAGDFSKASQAAECMFKL AqueK224_Aque KFENSAELRSIAMTLNLLIGRKGNLDSQTDYWTVATFFEISVLAEDYQKASHAAECMFKL .* *:: :.: * *:.:** : . ** *. :: .:** : :. *: : :* nsy-1_Cele KPPVW-------YLKSTMENIKLINRCAATISPI--EKEKQQFLFWSEFFMEATEADT-- Pk92B_Dmel KPPNW-------YLKSTIGNISLIHRFRKKPEERQPPIEEQVFQFWMDFFLEATNTEE-- MAP3K5_Mmus KTPAW-------YLKSIVETILIYKHFVKLTTEQP-SAKQELVDFWMDFLVEATKTDV-- MAP3K6_Mmus NAPIW-------YLVSVMETFLLYQHFRPTPE-PS-GGPPLRAHFWLHFLLQSCQPFKMA MAP3K7_Mmus KPPVW-------YLRSLVQNLLLIQRFKKPITEH--SPRQERLNFWLDIIFEATNEVT-- MAP3K7_Hsap KPPVW-------YLRSLVQNLLLIRRFKKTIIEH--SPRQERLNFWLDIIFEATNEVT-- MAP3K5_Hsap KTPAW-------YLKSIVETILIYKHFVKLTTEQP-VAKQELVDFWMDFLVEATKTDV-- MAP3K6_Hsap NAPIW-------YLVSVMETFLLYQHFRPTPE-PP-GGPPRRAHFWLHFLLQSCQPFKTA ASK_Spur KPPIW-------YLKSTLGNIQMICRVRPTSDEEP-TIDQQLFNFWLDFFVEATKEST-- AqueK224_Aque RPPYWLYTYTYRYLKSTISNIQLISQFRVTSEDAPMSQEAKVFEFWMEFLIEATKD---- ..* * ** * : .: : : ** .::.:: : nsy-1_Cele DISCPRYPVLILELNK------EFTPSYLTLNN--E--EGT--VILSHVLENSQQKKIHQ Pk92B_Dmel VKNSIRFPILILEPQK------IYMPSYVTINMDA--DEKS--IQIVNICLAH-----AK MAP3K5_Mmus --TVVRFPVLILEPTK------IYQPSYLSINNEV--EEKT--ISIWHV---L------P MAP3K6_Mmus PPQEDQCLVLVLEINK------VLLPARLEIQGTD--PVST--VTLSLL---D------P MAP3K7_Mmus --NGLRFPVLVIEPTK------VYQPSYVSINNEA--EERT--VSLWHV---S------P MAP3K7_Hsap --NGLRFPVLVIEPTK------VYQPSYVSINNEA--EERT--VSLWHV---S------P MAP3K5_Hsap --TVVRFPVLILEPTK------IYQPSYLSINNEV--EEKT--ISIWHV---L------P MAP3K6_Hsap CAQGDQCLVLVLEMNK------VLLPAKLEVRGTD--PVST--VTLSLL---E------P ASK_Spur --TDLRFPVLVLEPSK------IYKPSYITISEGDETQERS--IRLWHV---G-----LE AqueK224_Aque QYSNSQFPILLFEPNPQNVSEYQYIPSYIALHEAS--SSSTAKIEIWYQ---M-----SD : :*::* *: : : : : : nsy-1_Cele SELRGIHRWHFARNNIKAVTESKRDDRQLFLYVHEN-SDDFNLLFPTKAHCKKAYDDMKS Pk92B_Dmel NACKKIHDFLFVASKIKSVSLYKRDDRCAYLYVHHN-SDDFQIYFPSTERRQKFYDMILE MAP3K5_Mmus DDKKGIHEWNFGASSVRGVSISKFEERCCFLYVLHN-SDDFQIYFCTELHCKRFFEMVNT MAP3K6_Mmus ETQEDPSSWTFPVTSICGISTSKLDQRCCFLYALPP-AQDVQLCFPSVERCQRFCGLIQV MAP3K7_Mmus TEMKQIHEWNFTASSIKGISLSKFDERCCFLYVHDN-SDDFQIYFSTEDQCNRFCSLVKE MAP3K7_Hsap TEMKQMHEWNFTASSIKGISLSKFDERCCFLYVHDN-SDDFQIYFSTEEQCSRFFSLVKE MAP3K5_Hsap DDKKGIHEWNFSASSVRGVSISKFEERCCFLYVLHN-SDDFQIYFCTELHCKKFFEMVNT MAP3K6_Hsap ETQDIPSSWTFPVASICGVSASKRDERCCFLYALPP-AQDVQLCFPSVGHCQWFCGLIQA ASK_Spur KNSREISEWLFNLSSIKGVSTYKRDDRCLFLYVQQN-ADDFQLFYPSSSQRQRFHDLIMD AqueK224_Aque EDDVVVSEWAYEIACVRNVSIIKRDNRGLFLYVLDKYSDDFQMFFSSELQCSKVFQLILS : : : :: * ::* :**. ::*.:: : : : . : nsy-1_Cele MADVAD----GN-YQGRVLSNPDNEKIRFEYELSNSNERVVLGKGTYGTVYAARDMDTQR Pk92B_Dmel MTADQV-------VFVN-LS-NDDANIEYEYDYDEQNRKMVLGKGTYGTVYAARDKQTQV MAP3K5_Mmus ITEEK-----G--RGA-EDGDCEGDSLEYDYEYDENGDRVVLGKGTYGIVYAGRDLSNQV MAP3K6_Mmus LVMNPD----S--SAPTEEAEGAREVLEFDYEYSETGERLVLGRGTYGVVYAGRDRHTRV MAP3K7_Mmus MLNNGV----G--STVELEGEADGDTLEYEYDHDANGERVVLGKGSYGIVYAGRDLSNQV MAP3K7_Hsap MITNTA----G--STVELEGETDGDTLEYEYDHDANGERVVLGKGTYGIVYAGRDLSNQV MAP3K5_Hsap ITEEK-----G--RST-EEGDCESDLLEYDYEYDENGDRVVLGKGTYGIVYAGRDLSNQV MAP3K6_Hsap WVTNPD----S--TAPAEEAEGAGEMLEFDYEYTETGERLVLGKGTYGVVYAGRDRHTRV ASK_Spur MLGSSA----V--IGGEVDSDLNDEPIQIEYEFTESKDRVMLGRGTFGVVYAARDCRTQV AqueK224_Aque LMDSTKLEKSGSSKLTRRMTIDEEDTVEFEYELNDLHEPVVLGKGSFGIVYSAIDLVTKK :. :*: ::**:*::* **:. * .: nsy-1_Cele QIVVKEIEVKYDEEVQPLMEEISLHSTLCHANIVQYLGCDLVGKDGSNDHFLIFMEHVPG Pk92B_Dmel RIAIKEVPEKNSQDVQPLHEEIKLHSQLRHRNIVRYLGSC-----SENGFFKIFMEQVPG MAP3K5_Mmus RIAIKEIPERDSRYSQPLHEEIALHKHLKHKNIVQYLGSF-----SENGFIKIFMEQVPG MAP3K6_Mmus RIAIKEIPERDSRFSQPLHEEIALHKRLRHKNIVRYLGSA-----SQGGYLKIFMEEVPG MAP3K7_Mmus RIAIKEIPERDIRYSQPLHEEIALHKYLKHRNIVQYLGSV-----SENGYIKIFMEQVPG MAP3K7_Hsap RIAIKEIPERDSRYSQPLHEEIALHKYLKHRNIVQYLGSV-----SENGYIKIFMEQVPG MAP3K5_Hsap RIAIKEIPERDSRYSQPLHEEIALHKHLKHKNIVQYLGSF-----SENGFIKIFMEQVPG MAP3K6_Hsap RIAIKEIPERDSRFSQPLHEEIALHRRLRHKNIVRYLGSA-----SQGGYLKIFMEEVPG ASK_Spur TIAVKEIPITDMREVQPLHEEILLHSRLSHKNIVKYLGSD-----IVGNTFKIYMEQVPG AqueK224_Aque KMAIKEIPERTEGQFQSLEEEIQLHRHLQHENIVQYFGAY-----SDGGIFRIFMEQVPG :.:**: *.* *** ** * * ***:*:*. .. : *:**.*** nsy-1_Cele GSLSSLLRSKWGPMN--ENAMNYYGKQILEGLKYLHELKIVHRDIKGDNVLVNTYSGVCK Pk92B_Dmel GSLSDLLETKWGPLKDNESTMAFYSKQILEGLKYLHEQDIVHRDIKGDNVLVNTYSGVVK MAP3K5_Mmus GSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLK MAP3K6_Mmus GSLSSLLRSVWGPLKDNESTISFYTRQILQGLSYLHENRIVHRDIKGDNVLINTFSGLLK MAP3K7_Mmus GSLSALLRSKWGPMK--EPTIKFYTKQILEGLKYLHENQIVHRDIKGDNVLVNTYSGVVK MAP3K7_Hsap GSLSALLRSKWGPMK--EPTIKFYTKQILEGLKYLHENQIVHRDIKGDNVLVNTYSGVVK MAP3K5_Hsap GSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLK MAP3K6_Hsap GSLSSLLRSVWGPLKDNESTISFYTRQILQGLGYLHDNHIVHRDIKGDNVLINTFSGLLK ASK_Spur GSLSALLRSKWGPLKDHEDTIIYYTKQILEGLRYLHDQKIVHRDIKGDNVLVNTYSGVVK AqueK224_Aque GSLSHLLKFTWGPLINDEGTIRHYTRQILKGLGYLHNQKIVHRDIKGDNVLVNMYSGQIK **** **. ***: * :: .* :***:** ***: ************:* :** * nsy-1_Cele ISDFGTCKRLAGLNPVTETFTGTLQYMAPEVIDHGQRGYGAPADIWSFGCTMVEMATGRP Pk92B_Dmel ISDFGTSKRLARINPMTETFTGTLQYMAPEVIDQGVRGYGPAADIWSFGCTNVEMATGKP MAP3K5_Mmus ISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGYGKAADIWSLGCTIIEMATGKP MAP3K6_Mmus ISDFGTSKRLAGITPCTETFTGTLQYMAPEIIDQGPRGYGKAADIWSLGCTVIEMATGRP MAP3K7_Mmus ISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDQGPRGYGAPADIWSLGCTIIEMATSRP MAP3K7_Hsap ISDFGTSKRLAGVNPCTETFTGTLQYMAPEIIDQGPRGYGAPADIWSLGCTIIEMATSKP MAP3K5_Hsap ISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGYGKAADIWSLGCTIIEMATGKP MAP3K6_Hsap ISDFGTSKRLAGITPCTETFTGTLQYMAPEIIDQGPRGYGKAADIWSLGCTVIEMATGRP ASK_Spur ISDFGTSKRLAGLNPAASSFKGTLQYMAPEVIDKGLRGHGAPADIWSLGCTIVEMATGKP AqueK224_Aque ISDFG-----------------TFQFMAPEVIASGQRGYGPPADVWSLGCTVIEMVTGKP ***** *:*:****:* * **:* .**:**:*** :**.*.:* nsy-1_Cele PFVEMQNPQAAMFRVGMFKTHPPIPTEITEKCRNFIKSCFLPEACDRPSAKDLLQDPFIY Pk92B_Dmel PFIELGSAHAAMFKVGFYKKHPNIPEELSANAKNFILRCFAISVMDRPSASQLLEDPFLQ MAP3K5_Mmus PFYELGEPQAAMFKVGMFKVHPEIPESMSAEAKAFILKCFEPDPDKRACANDLLIDEFLK MAP3K6_Mmus PFHELGSPQAAMFQVGMYKVHPPVPGSLSAEAQAFLLRTFEPDPRLRASAQELLGDPFLQ MAP3K7_Mmus PFHELGEPQAAMFKVGMFKIHPEIPEALSAEARAFILSCFEPDPQKRVTAADLLQEGFLR MAP3K7_Hsap PFHELGEPQAAMFKVGMFKIHPEIPEALSAEARAFILSCFEPDPHKRATTAELLREGFLR MAP3K5_Hsap PFYELGEPQAAMFKVGMFKVHPEIPESMSAEAKAFILKCFEPDPDKRACANDLLVDEFLK MAP3K6_Hsap PFHELGSPQAAMFQVGMYKVHPPMPSSLSAEAQAFLLRTFEPDPRLRASAQTLLGDPFLQ ASK_Spur PFIELGSPQAAMFKVGFYKDHPEIPESLSNAAKEFILRCFEPDPEKRATAHDLLQDPFLI AqueK224_Aque PFFELGPPEAAVFKVGTFKEHPEIPDVLSKELKSFLLSCFEPEPSKRAIVSELLQNSFIT ** *: ..**:*:** :* ** :* :: : *: * . * . ** : *: nsy-1_Cele HNHHSISRTRSGSINKKPATKIELNHDKEKKEKSKNQREMLRSTSHIGGMGVVERSPPTP Pk92B_Dmel DKPRK--VRPAL--P--------------------INTEFGRSISV--------PA-DRF MAP3K5_Mmus VSSKKKKTQPKL--S----------------ALSTGSNEYLRSIS--------LPV-PVL MAP3K6_Mmus PGKRSRS---PG-----------------------SPRHTPRPSGAP------SGP-SSP MAP3K7_Mmus QVNKGKKNRIAF-----------------------KPSEGVRSGTGT------LAL-PSS MAP3K7_Hsap QVNKGKKNRIAF-----------------------KPSEGPRGVV--------LAL-PTQ MAP3K5_Hsap VSSKKKKTQPKL--S----------------ALSAGSNEYLRSIS--------LPV-PVL MAP3K6_Hsap PGKRSRS---PS-----------------------SPRHAPRPSDAP------SAS-PTP ASK_Spur KGRKMSKK-TSA-----------------------ADYRTDRSISM--------PM-VNP AqueK224_Aque RKKKK--VNVSD-----------------------APPEFMRSKSMF-------PG-A-- : . * nsy-1_Cele EPMSATLTAGFSHVHSQTVSNALSTAREEKKLHLKIDHARNRTFSSSSPV-PDGQSSA-- Pk92B_Dmel VHK-TTPPLS----YNTTCN--T----------------------PTTPEL-DITHSSSV MAP3K5_Mmus VED-TSSSSE----YG-----------------------------SVSPD-TELKADP-- MAP3K6_Mmus SADSATQSQT-----------------------------------FPRPQ-APSQH-P-- MAP3K7_Mmus GELVGSSSSE----HG-----------------------------SISPD-SDAQPDA-- MAP3K7_Hsap GEPMATSSSE----HG-----------------------------SVSPD-SDAQPDA-- MAP3K5_Hsap VED-TSSSSE----YG-----------------------------SVSPD-TELKVDP-- MAP3K6_Hsap SANSTTQSQT-----------------------------------FPCPQ-APSQH-P-- ASK_Spur GSRP-ESPLT----LASTLS--------------------------NFSEA-DAA---S- AqueK224_Aque ----------------------L----------------------PSAEHDKELTMSS-- nsy-1_Cele --GTNMSHPGFQLSQPSSPIVDDTNHPHLIVSPISLNTMGSPLSSAALLNRTISDES-SN Pk92B_Dmel DID---ELPSNQ-F-----------MLER--RNSHGFLLS-PEIEPSTPSLRTSISE-TS MAP3K5_Mmus --F---SFKARAKS-----------CGEKDGKGIRTLFLGIPDEN--FEDHSAPPSP-EE MAP3K6_Mmus --P---SPPKRCLS-----------YG-------DTSQLRVPEEPAA----EEPASP-EE MAP3K7_Mmus --F---FEKVQVPK-----------H-------QLSHLLSVPDESPALDDRSTALPP-EE MAP3K7_Hsap --L---FERTRAPR-----------H-------HLGHLLSVPDESSALEDRGLASSP-ED MAP3K5_Hsap --F---SFKTRAKS-----------CGERDVKGIRTLFLGIPDEN--FEDHSAPPSP-EE MAP3K6_Hsap --P---SPPKRCLS-----------YG-------GTSQLRVPEEPAA----EEPASP-EE ASK_Spur -S-------------------------------------------SSEDGLETPVTP-DN AqueK224_Aque --N---STPGASKS-----------ILERSKSASTQRKFSNSNEM--AEGSSEGETPTSS . nsy-1_Cele S-SS------RFFMLQKDSERRRSLGQFMQDYKDLIIDSWSTLLIKQSD-TELVVTVYML Pk92B_Dmel E-TD------GFYRLKKDSQRRTTLSKVLALDESKICDIWLKKVDADQ------------ MAP3K5_Mmus K-DS------GFFMLRKDSERRATLHRILTEDQDKVVRNLMESLAQGAEE--PKLKWEHI MAP3K6_Mmus --SS------GLSLLHQESKRRAMLAAVLEQEVPTLAENLLE---Q-EQD--SRLSKIHV MAP3K7_Mmus R-DP------GLFLLRKDSERRAILYRILWEEQNQVASNLQECVVQSSEE--LLLSVSHI MAP3K7_Hsap R-DQ------GLFLLRKDSERRAILYKILWEEQNQVASNLQECVAQSSEE--LHLSVGHI MAP3K5_Hsap K-DS------GFFMLRKDSERRATLHRILTEDQDKIVRNLMESLAQGAEE--PKLKWEHI MAP3K6_Hsap --SS------GLSLLHQESKRRAMLAAVLEQELPALAENLHQEQKQ-EQG--ARLGRNHV ASK_Spur REQG------GFYMLRKDSERRQTLLTIIEGDGDKIVNEWMKKLQLSGDRPPTKITTDHL AqueK224_Aque T-NDGVFSRSDFSRVLWDSE---------------------------------------- : : :*: nsy-1_Cele EMLLDGMRDFLLKKDNTKMQKMIDDIRGLLDYDTAKIGQINLALYHFSDSIQPVLRRL-- Pk92B_Dmel --------------------------------NSIAI-----RKSDLEDAVVCVLRYH-- MAP3K5_Mmus TTLISSLREFVRSTDRKIIATTLSKLKLELDFDSHGISQVQVVLFGFQDAVNKVLRNH-- MAP3K6_Mmus ELLLRCLGAQIHTPNRRQLAQELRTLQAQLRAQSLGPALLKGPLFAFPDAVKQILRRR-- MAP3K7_Mmus KQIIGILRDFIRSPEHRVMAATISKLKVDLDFDSSSINQIHLILFGFQDAVNRILRNH-- MAP3K7_Hsap KQIIGILRDFIRSPEHRVMATTISKLKVDLDFDSSSISQIHLVLFGFQDAVNKILRNH-- MAP3K5_Hsap TTLIASLREFVRSTDRKIIATTLSKLKLELDFDSHGISQVQVVLFGFQDAVNKVLRNH-- MAP3K6_Hsap EELLRCLGAHIHTPNRRQLAQELRALQGRLRAQGLGPALLHRPLFAFPDAVKQILRKR-- ASK_Spur MTLNHGIALFIKQRERRMLVGTLDKLRDDLDYDPTALSEIHTALYVFQDSVNQVLRQHMH AqueK224_Aque ------------------------------------------------------------ nsy-1_Cele DIKPHWMFALSNLITSAVQCAISILSPDLSLLL-HAQD-NLPSTSSIVAIR------N-- Pk92B_Dmel CIKPHWMFALDNLVKRAVQAAVTIFSPELGANL-ADKD-LSGNDDESLRTSLMQKGSTES MAP3K5_Mmus NIKPHWMFALDSIIRKAVQTAITILVPELRPHF-SLASESDTADPEDLDVE------DEH MAP3K6_Mmus QIRPHWMFVLDSLLSRAVRAAMAVLDAESEKKAVLPRSEE-SSKEE-SQ----------- MAP3K7_Mmus LIRPHWMFAMDNIIRRAVQAAVTILIPELQAHF-EPASETEGVDK-DTEVE------GDY MAP3K7_Hsap LIRPHWMFAMDNIIRRAVQAAVTILIPELRAHF-EPTCETEGVDK-DMDEA------EE- MAP3K5_Hsap NIKPHWMFALDSIIRKAVQTAITILVPELRPHF-SLASESDTADQEDLDVE------DDH MAP3K6_Hsap QIRPHWMFVLDSLLSRAVRAALGVLGPEVEKEAVSPRSEE-LSNEGDSQ----------- ASK_Spur NIKPHWMFALDSLIRDAVQVTITILSPDLGENI-APSKEDDVTPA-NSHGM-----DTRN AqueK224_Aque ------------------------------------------------------------ nsy-1_Cele SSL--SEG--------EAL-------------------------IESRPPSREERVREDR Pk92B_Dmel QEK--QSL--------EKV-LPTSNTREGV-----GLT-PAESGGDALSSSMECAR---- MAP3K5_Mmus EEL--SSN--------QTVRRPQAITEDAVATSGVSTL-SSTVSHDSQNAHRSLNV---- MAP3K6_Mmus -QK--PQE--------SQA------------------L-QSQL--PPEQGPPSLMV---- MAP3K7_Mmus PLVDLLSQ--------EVHVTPRGT----------R-P-GSVAIQEGQPHQQDPSL---- MAP3K7_Hsap -----------------------GY----------P-P-ATGPGQEAQPHQQHLSL---- MAP3K5_Hsap EEQ--PSN--------QTVRRPQAVIEDAVATSGVSTL-SSTVSHDSQSAHRSLNV---- MAP3K6_Hsap -QS--PGQ--------QSP------------------L--PV---EPEQGPAPLMV---- ASK_Spur PGTSSGGGGGIYGTAPHFLPLPKGVDEEAGNTSGVSTFDSSTRSNECFIPNRNLMA-NLQ AqueK224_Aque ------------------------------------------------------------ nsy-1_Cele KELRTLQEENEILIERL--------------L---------------------------- Pk92B_Dmel -ILRDIRDNQQKLQRQLLEQQRQSM----RALHNISQELAHIYMGGRKRLRRTINGFNKK MAP3K5_Mmus -QLGRMKIETNRLLEELVRKERELQALLHQAIEEKDQEIRHLKLKSQPI----------- MAP3K6_Mmus -ELGLLRAETDRLRDLLAEKERECQALVQQALHRVHAETRKYAPASE------------- MAP3K7_Mmus -QLSKLRQETNRLWEHLVQKEREYQNLLRLILDQKTQELYHLQLQYKSN----------- MAP3K7_Hsap -QLGELRQETNRLLEHLVEKEREYQNLLRQTLEQKTQELYHLQLKLKSN----------- MAP3K5_Hsap -QLGRMKIETNRLLEELVRKEKELQALLHRAIEEKDQEIKHLKLKSQPI----------- MAP3K6_Hsap -QLSLLRAETDRLREILAGKEREYQALVQRALQRLNEEARTYVLAPE------------- ASK_Spur GDHQRLVQEQGRLLQELVDVQKSLNDVLQTQLCVSRSVMERIG--FQPL----------- AqueK224_Aque ---------TKELLNIVLSKDREMV----KS----------------------------- * : nsy-1_Cele ------------------------------------QEELVSWLRGLEIDERSIALIASE Pk92B_Dmel CHRMSTSVGGTSGVRPNIAGNPRRQLNKHHFGLHEVDEQLEQWLTQQEIDEFSKTLILNE MAP3K5_Mmus ----------------DIPGFPVCHLN--SPGTTTEDSELPGWLRENGADEDTISRFLAE MAP3K6_Mmus -----------------------------TPATLPKDQNLVRWLQELSVDPATIQTLLSH MAP3K7_Mmus ----------------GGTENPP------PPDGLGTDRELIDWLQLQGVDANTIEKIVEE MAP3K7_Hsap ----------------CITENPA------GPYGQRTDKELIDWLRLQGADAKTIEKIVEE MAP3K5_Hsap ----------------EIPELPVFHLN--SSGTNTEDSELTDWLRVNGADEDTISRFLAE MAP3K6_Hsap -----------------------------PPTALSTDQGLVQWLQELNVDSGTIQMLLNH ASK_Spur ----------------GATDSVNSNLQDGRAGVEAKQEELSSWLQAVGLDEDSIRRFIEE AqueK224_Aque -------------------------------------------FFIARICKNVQKTLQEK : : . nsy-1_Cele AYTKSDMMDFVTRDELLSIGVGGGSSCRIMRAIGEVRERQRLF----------------- Pk92B_Dmel GFTFDDFIYNMEKLDLMRLGLRVGIEVRLWKLIIQERVCTSSDCVDSPPSTYHKPIGGNS MAP3K5_Mmus DYTLVDVLYYVTRDDLKCLRLRGGMLCTLWKAIIDFRN---------------------- MAP3K6_Mmus SFTLQTLLTCATQDDLVYTRIRGGMVCRIWRAILAQRAGATSV----------------- MAP3K7_Mmus DYTLSDILNDITKEDLRCLRLRGGVLCRLWHAVSQHRRQMQ------------------- MAP3K7_Hsap GYTLSDILNEITKEDLRYLRLRGGLLCRLWSAVSQYRRAQEAS----------------- MAP3K5_Hsap DYTLLDVLYYVTRDDLKCLRLRGGMLCTLWKAIIDFRNK--------------------- MAP3K6_Hsap SFTLHTLLTYATRDDLIYTRIRGGMVCRIWRAILAQRAGSTPV----------------- ASK_Spur DLTLPLVLNSMTRDDLRSLKIRVGAQVRIWDAVQQHRMNE-------------------- AqueK224_Aque IPSLHLTMVHNTHDK----EGGGGLFL--------------------------------- : : : . * nsy-1_Cele --------------------------------LSLSLILL Pk92B_Dmel SFALIDNNNTLPSPTTTTPGTPGIKTKIKKSESEYDSCSE MAP3K5_Mmus --------------------------------------KC MAP3K6_Mmus --------------------------------TPVPRDAE MAP3K7_Mmus ------------------------------------ESSQ MAP3K7_Hsap ----------------------------------ETKDKA MAP3K5_Hsap --------------------------------------QT MAP3K6_Hsap ------------------------------------TSGP ASK_Spur -------------------------------------QKR AqueK224_Aque -----------------------------------FLGTP