CLUSTAL W (1.83) multiple sequence alignment mei-41_Dmel MYAKSL------------------------------------------------------ ATR_Mmus MGDHGL--------------------------------E--------------------- atl-1_Cele MNIDKDVSALLCTAKKYVTQKEFNRQKMKFLLDDITKLLSKSFVSRIEQLDENEFMEKIM MEC1_Scer MESHVK--------------------------------Y--------------------- ATR_Hsap MGEHGL--------------------------------E--------------------- ATR_Ddis MPSEQFQEQQRQQQQQYQQQLERERQEKEQNEKESLISN--------------------- ATR_Spur SSYQ-------------------------------------------------------- CC1G_08126_Ccin MSTNAS--------------------------------K--------------------- AqueK044_Aque MLMV-------------------------------------------------------- ATR_Smoe MIFCRGMD---------------------------------------------------- mei-41_Dmel --------LEVLQHAHHIGYAT-------------------------------------- ATR_Mmus -------LASMIPALRELASATPEEYNTVVQ----------------------------- atl-1_Cele ILQSITFTLHLITEKQELSS---EEKIRLFQ----------------------------- MEC1_Scer -------LDELILAIKDLNSGVDSKV----Q----------------------------- ATR_Hsap -------LASMIPALRELGSATPEEYNTVVQ----------------------------- ATR_Ddis -------LVSLIIEIQQLGG---NEYNSQNHPINLSKDSIVDDKNNKKDLDTTSVTNNNK ATR_Spur ------------------------------------------------------------ CC1G_08126_Ccin -------ATTELDGAANA---NSSNFK--NS----------------------------- AqueK044_Aque ------------------------------------------------------------ ATR_Smoe ------------------------EDNE-------------------------------- mei-41_Dmel ---------------------------HGDIFSGSL-HQ---------------ALLILK ATR_Mmus ----------KPRQILCQF--------IDRILTDVN-VV---------------ALELVK atl-1_Cele ----------SVIASMCAFEDEELAKCFDRILSVLM-ISVTKQDPRETIYFLQGLLEVVK MEC1_Scer ----------------------------------------------------------IK ATR_Hsap ----------KPRQILCQF--------IDRILTDVN-VV---------------AVELVK ATR_Ddis QQQQQNKTTHKIQQKYELY--------ISRIRSILPELI---------------NSHLVS ATR_Spur ------------------------------------------------------------ CC1G_08126_Ccin --------------GLFKS--------LNQVL------------------------EDLK AqueK044_Aque ------------------------------------------------------------ ATR_Smoe ----------QVQEALCST--------IGKL---FC-VA---------------AANLVP mei-41_Dmel E---CDM-DTKLASL---------------NYCHNVLRSQSA------------------ ATR_Mmus K---TDAQPTSVMLL---------------DFIQHIMKSSPLMFVNVNGSQGQNEAKDSC atl-1_Cele Y---CDVEPSSSLPQLITPEIASAISLGASGFFRYHLKW------NII-STLFGENAGEC MEC1_Scer K---VPTDPSSSQ----------------------------------------------- ATR_Hsap K---TDSQPTSVMLL---------------DFIQHIMKSSPLMFVNVSGS---HEAKGSC ATR_Ddis TASISDIN----QIV---------------KLISYLIEKIPNS------SLAIGDSSGDI ATR_Spur ------------------------------------------------------------ CC1G_08126_Ccin R---R---PEGFDPA---------------DASHRVLEVAQSF----------------- AqueK044_Aque ------------------------------------------------------------ ATR_Smoe T---SDMQ---------------------------------------------------- mei-41_Dmel ---SSWIT---------------------------------------------------- ATR_Mmus IEFSHWIITRLLRIAATPSCH-MLHKKICE------VICS-LLF---------------- atl-1_Cele VHFDELVL-FWPH------CRSQLEDKLKNDCSMTENCLRAGLTILKYKKLHNSILDQAL MEC1_Scer -----------------------EYAKSLK------ILNT-LIR---------------- ATR_Hsap IEFSNWIITRLLRIAATPSCH-LLHKKICE------VICS-LLF---------------- ATR_Ddis CFFLFKLIPFLSHKSSTNICS-QQHQQLDENEEFTENLITAIKAML-------------- ATR_Spur -----------------------MRQRR-------------------------------- CC1G_08126_Ccin ----------LCGYASPHTTR-AWADLMEEIIPLTEGLLALIQM---------------- AqueK044_Aque ------------------------------------------------------------ ATR_Smoe -------------QLSCNICD-N--------------GIASASAVL-------------- mei-41_Dmel ------------------NPDVGHYA------------------QLTLEATAI-----MW ATR_Mmus -------------LFKSKNPAIFGVLTRELLYLFEDL--IYLHK-RNAVGEVM-----EW atl-1_Cele FIDELFATFNSLTAKKSTNHMTFPKLLNEIQHFLQDHGKVLIMH-KELRQKPV-----QW MEC1_Scer -------------NLKD------------------------QRR-NNIMK-----NDT-- ATR_Hsap -------------LFKSKSPAIFGVLTKELLQLFEDL--VYLHR-RNVMGHAV-----EW ATR_Ddis -------------NFLNDDANVLLLFFKETICLFKDC--IDFIKCLNSSNNQQEQEKSIF ATR_Spur ------------------------------------------------------------ CC1G_08126_Ccin -------------MFATQSPSIYHYMRDSVKIVFCRL--VDIGY------TLGL-----W AqueK044_Aque ------------------------------------------------------------ ATR_Smoe ------------------------------------------------------------ mei-41_Dmel SAVA-KWL----------------D--MGCMTRQEL-KR--------------------- ATR_Mmus PVVVSRFLS-------------RLDEHMGCLQPAPL-QF--------------------- atl-1_Cele LIIYLELID-------------DANDKFGLLENFSL-LL--------------------- MEC1_Scer --IFSKTVS-------------ALALLL---EYNPFLLVM--------------KDSNGN ATR_Hsap PVVMSRFLS-------------QLDEHMGYLQSAPL-QL--------------------- ATR_Ddis PMVLKTYCELSSSVIINSNTTGNTSSYSKHYQSLDL-LV---------------QTEMAF ATR_Spur ------------------------------------------------------------ CC1G_08126_Ccin MDVV-EPDD--------------------EIQPSPG-KLRNSVLEVLAEVLSGLPKPFPR AqueK044_Aque ------------------------------------------------------------ ATR_Smoe -------------------------------KDLE------------------------- mei-41_Dmel --------------------------------------LNITT----------------- ATR_Mmus --------------------------------------MNVQN--VEFIEVTLLMV---- atl-1_Cele --------------------------------------LDLST----------------- MEC1_Scer F--------------------------------------EIQRLIDDFLNISVLNY---- ATR_Hsap --------------------------------------MSMQN--LEFIEVTLLMV---- ATR_Ddis NQYSKNNNNNNNNNNNSEKDKNIEKEKSN---------SNDDN--SKSIDEGVIIV---- ATR_Spur ------------------------------------------------------------ CC1G_08126_Ccin L-PAP---------------------ARSISSDQFAEAQKFQN--PEALKVLREMVNEVV AqueK044_Aque ------------------------------------------------------------ ATR_Smoe ------------------------------------------------------------ mei-41_Dmel -----------------------------------------KLLLEV----LH---MRAR ATR_Mmus -LIHIVPTVFFRRQELLLWQIGCALLEHGSPKI---RSLAISLLTEL----FELGGLPA- atl-1_Cele ----------------------------------------------NH----DIHEFPA- MEC1_Scer ---DNYHRIWFMRRKLGSWCKACVEF-YGKPAK---FQLTAHFEN--------------- ATR_Hsap -LTRIIAIVFFRRQELLLWQIGCVLLEYGSPKI---KSLAISFLTEL----FQLGGLPA- ATR_Ddis -ISSINRLI--NLQYGLLVSISS-VIDNFSPIL---YSVSIDLWDVLSQYLFLLNDLKLS ATR_Spur ----------------------CA------------------------------------ CC1G_08126_Ccin ELTDIVQLYLGTERRLLVESARRVFDYILSPSCHFTNDRRIRWLGKL----FQVVLETL- AqueK044_Aque ------------------------------------------------------------ ATR_Smoe ----------------------------------------YPY----------------- mei-41_Dmel PAHHLGYLLLNEILSLPTA----------IE-LDDGLLETLS------------------ ATR_Mmus --QPASTFFSLFLELLQHL----------VG-MDADQLKLYEEPLSKLLKT--------- atl-1_Cele --RLCMTASEICMRRIKHS----------IQSTHTDCLADYLDILASLLKLARIQKLDIF MEC1_Scer -------TMNLYEQALTEV----------L-LGKTELLKFYD-TLKGLYIL--------- ATR_Hsap --QPASTFFSSFLELLKHL----------VE-MDTDQLKLYEEPLSKLIKT--------- ATR_Ddis SFKYMANFIYSLLVLFEKL----------LK-LSSNQIP--------------------- ATR_Spur ------------------------------------------------------------ CC1G_08126_Ccin --SDTGPLFSYMQERLLHSRYDGTIHGNTTT-LDVLLNQSFDRPFSTASRA--------- AqueK044_Aque ------------------------------------------------------------ ATR_Smoe ------------------------------------------------------------ mei-41_Dmel ----------------SYIQGQLEHSVVPLEQ--LVHLQQLMLSHWHCHPTHLVPILALM ATR_Mmus -LFPFEAEAYRNIE-PVYLNVLLEKLSVMFEDRVLMRLKSDLLKAALCHLLQYFLTFVPA atl-1_Cele QCFATEIEAHHSLNNPLWP-----------------RILRSLLSVQNPHCQQFCKKFVPS MEC1_Scer -LYWFTSEYSTF------------GNSIAFLDSSLGFTKFDFNFQRLIRIV--------- ATR_Hsap -LFPFEAEAYRNIE-PVYLNMLLEKLCVMFEDGVLMRLKSDLLKAALCHLLQYFLKFVPA ATR_Ddis ------ALLYNNIV-GQFFNVLLP-MSMLLNDKDCSKRREE-IDIKLTSIIPLLFSNVPS ATR_Spur ------------------------------------------------------------ CC1G_08126_Ccin -V-VYQALG--------------------------------------------------- AqueK044_Aque ------------------------------------------------------------ ATR_Smoe ------------------------------------------------------------ mei-41_Dmel G-----------------LKQ-TEMRSGVVQVLTQ-SLVEILKKEEVLSKDWQKLIAILR ATR_Mmus G-----------------YESALQVRKVYVTNICR-ALVDALGVQKHVGYLLGPFYAALK atl-1_Cele IDK-----LWITLLNGES-SRATLNSLVIVTASCPFANNNDEGVKQIIPFLLIPCFQDFR MEC1_Scer ---------------------------LYVFDSCE---------------LAALEYAEIQ ATR_Hsap G-----------------YESALQVRKVYVRNICK-ALLDVLGIEVDAEYLLGPLYAALK ATR_Ddis STLFDFSSIILPNILFIINNTNLTELKVSILDIYL-NILKLSELQFKSIYNLVPLFGDEG ATR_Spur ---------------------------------------EIFSRAKALDK---------- CC1G_08126_Ccin -----------------------------------------------------CLNASPN AqueK044_Aque ------------------------------------------------------------ ATR_Smoe ------------------------------------------------------------ mei-41_Dmel ------------------------------GF---------------------------- ATR_Mmus -----------------MESK--------------------------------------- atl-1_Cele DRVGSKWDNFRFIGLPKSEPS--------------------------------------- MEC1_Scer -----------------LKYI--------------------------------------- ATR_Hsap -----------------MESM--------------------------------------- ATR_Ddis -----------------IHDKLYQCFDYVINQSYLIDTDDDDDDTDIDISLEILNTLIDY ATR_Spur ------------------------------------------------------------ CC1G_08126_Ccin -----------------DE------------------------------RNPQVHT---- AqueK044_Aque ------------------------------------------------------------ ATR_Smoe ------------------------------------------------------------ mei-41_Dmel ----------KQLEKLI-------LSQSQHKIAEHE-GHIDSSVLA--ML---------P ATR_Mmus ----------EIIERIQCQAQQENLSGNNDEVSPKR-RKLSSSLSSYKKP---------S atl-1_Cele ----------ELINLERFTTVLERSTSE----STKL-RAVNCALQLEKKT---------G MEC1_Scer ----------SLVVDYVCN------------------RTISTALDA-------------- ATR_Hsap ----------EIIEEIQCQTQQENLSSNSDGISPKR-RRLSSSLNPSKRA---------P ATR_Ddis SNCLNISNIYESISTVTNSVKDKNIDNNTENIEKDD-GDGGAGGTSENVN---------N ATR_Spur ------------------------------------------------------------ CC1G_08126_Ccin ---------------LAISYLKHSLSGIDKELLPLVLKHLQATLGHAIEPPRTLIKATQP AqueK044_Aque ------------------------------------------------------------ ATR_Smoe ------------------------------------------------------------ mei-41_Dmel LQCEIIKVADTN------------------------------------------------ ATR_Mmus RQPEEIIHVDMDKKSILWNVLKQKAESLQISLECGTLKNSVAEALEG------------- atl-1_Cele KYINLVAEMSL--------AVFSKSQTDRIANSFEPLILFLTDNLQLINDFITILIAKLC MEC1_Scer ---------------------------------------PALVCCEQ------------- ATR_Hsap KQTEEIKHVDMNQKSILWSALKQKAESLQISLEYSGLKNPVIEMLEG------------- ATR_Ddis KQIE-------NQKSITEDSKQQQQQQQ---------QQPTIEQQKS------------- ATR_Spur ------------------------------------------------------------ CC1G_08126_Ccin KPSAGSTQARMNLKDHVWRRQVQELVQAII------------------------------ AqueK044_Aque ------------------------------------------------------------ ATR_Smoe ------------------------------------------------------------ mei-41_Dmel ---------------------------------------WNNLSM--------------- ATR_Mmus --------ITVVLQLTALCTVHC---SHQDMDGHNVKDHQHKYKKKPPVVVTWMSLDF-- atl-1_Cele EKQEFYSELTILKYFKTLQKLFCLAANGRNSCKKCGEECFVDPDSKENVKIDYESLSGLI MEC1_Scer --------LKF------------------------------------------------- ATR_Hsap --------IAVVLQLTALCTVHC---SHQNMNCRTFKDCQHKSKKKPSVVITWMSLDF-- ATR_Ddis --------IRIYLKALHLIFKIC---K----------NHHNRVSVKELVNLFINNLNF-- ATR_Spur ------------------------------------------------------------ CC1G_08126_Ccin ----------------------------------------------SPDSITWMDDDF-- AqueK044_Aque ------------------------------------------------------------ ATR_Smoe ------------------------------------------------------------ mei-41_Dmel ------------------------------------------------------------ ATR_Mmus --------------Y-----------------------------------TKVLKSCRSL atl-1_Cele KGIVARRNTFSQELI-----------------------------------REFLQTSRVM MEC1_Scer ----------------------------------------------------VLTTMHHF ATR_Hsap --------------Y-----------------------------------TKVLKSCRSL ATR_Ddis --------------IYDLIIQQKELDNLFLEVLMDLLKLSSTVEIEYLHRISTLKSNEQL ATR_Spur ------------------------------------------------------------ CC1G_08126_Ccin --------------R-----------------------------------PNEPYTLRRI AqueK044_Aque ------------------------------------------------------------ ATR_Smoe ------------------------------------------------------------ mei-41_Dmel -----QLVELESK-----------------CSADRRHIHLEICS----------LLM--- ATR_Mmus LES-VQKLELELVIDS-MVRICDALMYMQVKSSFKDHVLEELCG----------MLS--- atl-1_Cele LLH-VDSKGIASSFTS-IIKALDIGFSENANAYFR--VWELVCCRSEATVEKKLQMY--- MEC1_Scer LDNKYGLLDNDPTMAKGILRLYSLCISNDFSKCFVDHFPIDQWA----------DFSQSE ATR_Hsap LES-VQKLDLEATIDK-VVKIYDALIYMQVNSSFEDHILEDLCG----------MLS--- ATR_Ddis LES-LFKLST--IVTN-HSTIFNLTKYAEIINSIKVISFSLVCW---------------- ATR_Spur ------------------------------------------------------------ CC1G_08126_Ccin LAD-V-------------------------------------AE----------RFS--- AqueK044_Aque ------------------------------------------------------------ ATR_Smoe ------------------------------------------------------------ mei-41_Dmel ----------------------------------------------------------QI ATR_Mmus -L----------------------------------PWIY----SYSDD-NSLKMTT--- atl-1_Cele -I----------------------------------PLIGRSFALLGDDA-ALKVHG--- MEC1_Scer HFPFTQLTNKALSIVYFDLKRRSLPVEALKYDNKFNIWVY----QSEPD-SSLKNVTS-- ATR_Hsap -L----------------------------------PWIY----SHSDD-GCLKLTT--- ATR_Ddis -L----------------------------------PCSY----YVNER-VDIVLSTLSL ATR_Spur ------------------------------------------------------------ CC1G_08126_Ccin -R----------------------------------PL------SQADDESRIKL----- AqueK044_Aque ------------------------------------------------------------ ATR_Smoe ------------------------------------------------------------ mei-41_Dmel ------------------------TFIRHF------------------------------ ATR_Mmus -------------------------FATNLLPLSQRVWDSYSPQ---------------- atl-1_Cele -------------------------FLSNVL--SARLSSTVKA----------------- MEC1_Scer -----------------------------------PFDDRYKQL---------------- ATR_Hsap -------------------------FAANLLTLSCRISDSYSPQ---------------- ATR_Ddis NKSLVNSTTTTTTTTTTTTTTTTTTATTNTTTTTATTTDKSSSQQNVGESNKNNPTIVSS ATR_Spur ------------------------------------------------------------ CC1G_08126_Ccin --------------------------ARNLAKLPCLLVV--------------------- AqueK044_Aque ------------------------------------------------------------ ATR_Smoe ------------------------------------------------------------ mei-41_Dmel ----------------------------------------LKTQTQH---QLLAIL---Q ATR_Mmus --------------------------------------------AQSKCVFLLTLF---P atl-1_Cele -------------------------------------------TLF-ASSFAHSV----L MEC1_Scer --------------------------------------------EKLRL-LVLKKFNKTE ATR_Hsap --------------------------------------------AQSRCVFLLTLF---P ATR_Ddis SPILVNISSDTSSSMGDSQAISASQQQQRNNNNNNKGEKYLSKLDQNYLINVIKLL---P ATR_Spur ------------------------------------------------------------ CC1G_08126_Ccin -------------------------------------------------------C---T AqueK044_Aque ------------------------------------------------------------ ATR_Smoe ------------------------------------------------------------ mei-41_Dmel RHLKLSYLCAIRLETPSSVHTQMQSFYAQQYMRLFQSEETQEIFCSNLPQLYISGFIKPE ATR_Mmus RRIFLEWRTAVYNWALKSSHEVIRASCVKGFFILLHQ----QNSCNQIPKMLVDRVKDDS atl-1_Cele KNCEIDWNV-SYTWKTQFSQCLIKAP--------------------------VGTCEEAL MEC1_Scer RGTLLKYRV------------------------------------NQLSPGFFQRAGNDF ATR_Hsap RRIFLEWRTAVYNWALQSSHEVIRASCVSGFFILLQQ----QNSCNRVPKILIDKVKDDS ATR_Ddis --VFISNMSPVNSLATISTNH--------------QY----QIMCNDIIKRLESIIDLNV ATR_Spur ------------------------------------------------------------ CC1G_08126_Ccin GESCTTF-------------RNASGPSLLGFYVPILQA------------LLAGPADEVT AqueK044_Aque ------------------------------------------------------------ ATR_Smoe ------WKTVV------------------------------------------------- mei-41_Dmel -------------------QLMKALPTINNRSGRAQVIRLLLCSQPGKLSV--------- ATR_Mmus -------------------DMVK--------KEFASVLGQLVCTLHGMFYLSSSV---EP atl-1_Cele -------------------QIMF--------KRYSTIFTR--CFLNRLFFDASSAGAQKP MEC1_Scer KLILNEASVSIQTCFKTNNITRL--------TSWTVILGRLACLESEKFSGT--L----- ATR_Hsap -------------------DIVK--------KEFASILGQLVCTLHGMFYLTSSLT--EP ATR_Ddis T------------------SLIL--------DMVGVIGGSLYCLKEGYCFFEN-LN--RC ATR_Spur ------------------------------------------------------------ CC1G_08126_Ccin -------------------PSVR--------REVYSV----------------------- AqueK044_Aque ------------------------------------------------------------ ATR_Smoe ------------------------------------------------------------ mei-41_Dmel F----------------------------------------------------------- ATR_Mmus C----------------------------------------------------------- atl-1_Cele SY---------------------------------------------------------- MEC1_Scer ------------------------------------------------------------ ATR_Hsap F----------------------------------------------------------- ATR_Ddis TYLNNNNNNNNNNNNNNNNNNNNNNNIQEQNNLIIINNSILLQRFTDTKNNRIKIDPLLS ATR_Spur ------------------------------------------------------------ CC1G_08126_Ccin ------------------------------------------------------------ AqueK044_Aque ------------------------------------------------------------ ATR_Smoe ------------------------------------------------------------ mei-41_Dmel -----------------------------KVKDRIEL-YCPKCRPLPKKLPGI------- ATR_Mmus -----------------------------FE--HMDL-FSKNLKATS------------- atl-1_Cele -----------------------------DEHRIREITRCYLSHVLS------------- MEC1_Scer --------------------------------------------------PNSTKDMDNW ATR_Hsap -----------------------------SEHGHVDL-FCRNLKATS------------- ATR_Ddis NYNNLVGCGIFEGVWLPLCSCKCVTVSSVLNTNIVDL-NLKPYRPIHKSPPSNNNNNNNE ATR_Spur ------------------------------------------------------------ CC1G_08126_Ccin ------------------------------------------------------------ AqueK044_Aque ------------------------------------------------------------ ATR_Smoe ------------------------------------------------------------ mei-41_Dmel ------------------------------------------------------------ ATR_Mmus ------------------------------------QHECS------------------- atl-1_Cele ------------------------------------DFNFP------------------- MEC1_Scer YVCHLCDIEKTGNP---------------------------------------------- ATR_Hsap ------------------------------------QHECS------------------- ATR_Ddis KDETIMDIDKTNNNEQILILESKYKENILFSKLFLEYHDGQNSDLDNDTSMMTSGGGDGD ATR_Spur ------------------------------------------------------------ CC1G_08126_Ccin ------------------------------------------------------------ AqueK044_Aque ------------------------------------------------------------ ATR_Smoe ------------------------------------------------------------ mei-41_Dmel -------------------------------------------------------YLGKC ATR_Mmus --------------------------------------------SSQVKASTCKPFLFLL atl-1_Cele --------------------------------------------NQKITFNMIRPSLL-- MEC1_Scer -------------FV-RINPNRPEAAGKSEIFRILHSNFLSHPNIDEFSESLLS------ ATR_Hsap --------------------------------------------SSQLKASVCKPFLFLL ATR_Ddis HDSSIKYFYLGFTFKNILIHNSPLPSTSIEGFFKFYLNLLSANRNDIIRKSVIKIIISML ATR_Spur ------------------------------------------------------------ CC1G_08126_Ccin ------------------------------------------------------------ AqueK044_Aque ------------------------------------------------------------ ATR_Smoe --------------------------------------------------------LKLL mei-41_Dmel KQQL--PCPDFSSTNLEMIANDLLFYPDFECIAQHLDLLCFE-PNV--ILGL-------- ATR_Mmus TKNT--PSP-----------VKLAFIDNLHHLCKHLDFQEDE-REVKAVLGT-------- atl-1_Cele ------------------------------------------------------------ MEC1_Scer -----------------------GILFSLHRIFS-----------------HFQPPKLTD ATR_Hsap KKKI--PSP-----------VKLAFIDNLHHLCKHLDFREDE-TDVKAVLGT-------- ATR_Ddis KFNYQTNPD-----------VLTNFFYQLHPLYSNKSEREDILFSILYLLKK-------- ATR_Spur ------------------------------------------------------------ CC1G_08126_Ccin ----------------------------LLPVLKH---RNEE-EPDEPVLEM-------- AqueK044_Aque ------------------------------------------------------------ ATR_Smoe LTNR--SYR-----------VQSAVVRNLSRLLAH-SFEGDA-RDIWVKCLD-------- mei-41_Dmel -----------LRE-TE-ALQKVSVKVIGQ--LVSAM-RVRS---P--EFL---EQLANL ATR_Mmus -----------LLNLMEDPDKDVRIAFSGN--IKYILE-SLN---SEDGFV---KEL--F atl-1_Cele ------------------------------------------------------------ MEC1_Scer GNGQINKSFKLVQKCFMNSNRYLRLLSTRIIPLFNISD-SHN---SEDEHT---ATL--I ATR_Hsap -----------LLNLMEDPDKDVRVAFSGN--IKHILE-SLD---SEDGFI---KEL--F ATR_Ddis -----------IANLIIQSQKD-----------QYILNNSLN---NNNNNN---NNN--N ATR_Spur ------------------------------------------------------------ CC1G_08126_Ccin -----------ITRGVTDDDRAVRVQAGLT--LQAVVE-FYS---GNTLASRQNIEN--F AqueK044_Aque ------------------------------------------------------------ ATR_Smoe -----------VF--PLHPDRSARKAFCSQ--LRGLLT-QEHIWYSTVGHK---SGD--Y mei-41_Dmel VL-----------AAIKAMLAKPLTEQNVLQQRSMLNVLTAIAHMEDNEIWLFHWFKMTF ATR_Mmus VL-----------RMKEAYTHAQIARNNELKDTLIL-TTGDIGRAAKGDLIPFALLHLLH atl-1_Cele ----------------------------------------------------------YW MEC1_Scer KFLQSQKLPVVKENLVIAWTQLTLTTSNDVFDTLLL-KLIDIFNSDDYSLRI-------- ATR_Hsap VL-----------RMKEAYTHAQISRNNELKDTLIL-TTGDIGRAAKGDLVPFALLHLLH ATR_Ddis V---------------QQLSSSSSSHNNQLNNNNTT-TTNNDSITWQDKIYSNDFILIIF ATR_Spur ------------------------------------------------------------ CC1G_08126_Ccin FH-----------RLYQVFEG----CRHSIKETLLI-SVGSLGKTANPFILGSTL-CLLI AqueK044_Aque ------------------------------------------------------------ ATR_Smoe E------------ILKKLGDALAIATDPDVLETLME-TVAEVGKVAKGDELRVSATILLI mei-41_Dmel FFLVHTRSLVAQEAVLAATEMCASQGLQTI--------HLWNWYKRDALDLTVRL---A- ATR_Mmus CLLSKSAS-VS---GAAYTEIRALVAAKSVK-----LQNFFSQYKKPICQFLVESLHSSQ atl-1_Cele SLLSS----ARGIN---------------SK------LTL------SVIDFICQEMSAAS MEC1_Scer ------------------------------------------------------------ ATR_Hsap CLLSKSAS-VS---GAAYTEIRALVAAKSVK-----LQSFFSQYKKPICQFLVESLHSSQ ATR_Ddis CTLIENLSRQTTIKVNSIET-IEFIAKKLNQTPKTLMMTNMAQYIN---PRIIENLYTN- ATR_Spur ------------------------------K-----LQ---------------------- CC1G_08126_Ccin LQLGQSNLLLH---SLACTQLLNISRHHKKS-----IYSLLSPHFDRVVKIVFERLSTQ- AqueK044_Aque ------------------------------------------------------------ ATR_Smoe EQLDKSEVSAR---AVSVRLICEIAAAQWPSDSNRCVERMVDSSSEILFEFFLKNLVLR- mei-41_Dmel -----------LNVYLLDGVRF-T---RSLRALTKMLGFTCVQEFTCKYHRLLTAMVLPH ATR_Mmus MTALPSAPCQSSEIRKQDVAHHREMALNTLSEIANVFDFPDLNRFLTRTL----QVLLPD atl-1_Cele V--SMSSIS--PNPSDIRIVM---IQRKSLI---------------TETF----AQLVQF MEC1_Scer ---------------------------------MMTLQIKNMAKILKKTP----YQL--- ATR_Hsap MTALPNTPCQNADVRKQDVAHQREMALNTLSEIANVFDFPDLNRFLTRTL----QVLLPD ATR_Ddis --------------------------RQSLVELCRYFLGIGLNQFLISSL----PTVIPV ATR_Spur ------------------------------------------------------------ CC1G_08126_Ccin --------------------------PTLLTELCRLMQ-LNIEEFISRHH----AKALPD AqueK044_Aque ------------------------------------------------------------ ATR_Smoe --------------------------PFLVKEFAEAVMKISTGDLLRKMI----PYVLPK mei-41_Dmel CIVNP--L--CKGVLVLIAKQMQ-KHIGTLFS-ISFLRIYTHVFLTEEPELANSCIELVV ATR_Mmus LAAKA--SPAASALIRTLGKQLN-VSRREILI-NNFKYIFSHLVCSCSKDELERALHYLK atl-1_Cele LAFEN--NRNTTSFWKFCS--------------------------------------DH- MEC1_Scer ------LSPILPVLLRQLGKNL-V-E-RKVGFQ-NLI----------------------- ATR_Hsap LAAKA--SPAASALIRTLGKQLN-VNRREILI-NNFKYIFSHLVCSCSKDELERALHYLK ATR_Ddis LIFKS--SNNILNCLKDELKDLKELCGQDYLMGLIFEYIFIHA---TSVENLTSCIICFC ATR_Spur --------------------------------------KFIHVLSVSL------------ CC1G_08126_Ccin VLLRC--DMKGVDLI---AHSLG-KNRSTTIL-DSLDKILVPILLLPTVPQTNKAVAFLI AqueK044_Aque ------------------------------------------------------------ ATR_Smoe LILDQQHDERAPQTLNTLAHLLQ-TSLPLVLL-EWCHKVLSVLLLRADGRELMAALHFYE mei-41_Dmel S-------CTQSSLQQLMNADVKQTVAELLIYFNRN---PTFVMRSFQSLLQLSIGS--L ATR_Mmus N-------ETEIELGSLLRQDFQGLHNELLLRIGEH---YQQVFNGLSILASFASSDDPY atl-1_Cele ------CDFKDEDIRTVISSYRKQVFMHLLLVSAREFLNPRNPSMIVEQLRATYEN--IK MEC1_Scer --------------------ELLGYSSKTILDIFQ---RYII----------------P- ATR_Hsap N-------ETEIELGSLLRQDFQGLHNELLLRIGEH---YQQVFNGLSILASFASSDDPY ATR_Ddis R-------FADFNQDAVVSNLPKSFINSLILNLANG--DGQQAKK------------ALD ATR_Spur ------------------------------------------------------------ CC1G_08126_Ccin GIFNEDSRDAKISLQTILPGHTTSVLTELVIRMGVD--DPQSRHQALNAVKKVETA--LQ AqueK044_Aque ------------------------------------------------------------ ATR_Smoe A-------QTGSDAREIFAAVLPALLDELVWFLGDT--SNDEAVK-----RSARVGPMIQ mei-41_Dmel EELSSQTANAEFANFIAERF-------LGVITYFES--CLSEPSFEKPLKEET---LYSL ATR_Mmus QGPRDITSPELMADYLQPKL-------LGILAFFNM--QLLSSSVGIEDKKMA---LTSL atl-1_Cele ----------KGEKFMISTAIETRNEGIEFLFIFRTYF--TNDQYFLT-REAT---AESF MEC1_Scer --------------------------------YAIIQ--YK-SDVLSEIAKIMCDGDTSL ATR_Hsap QGPRDIISPELMADYLQPKL-------LGILAFFNM--QLLSSSVGIEDKKMA---LNSL ATR_Ddis YVSQFVGGDMTFDKFLIKEF-------LGSMNFFTM--IMTNKQKSTQEKLTM---MTSF ATR_Spur ------------------------------------------------------------ CC1G_08126_Ccin KGTISISQKANPSEFLATQM-------LGIMSKIIDTLQDVHGKKSVEAKEQI---IRSI AqueK044_Aque ------------------------------------------------------------ ATR_Smoe EVARIISGSDDLPSFLRQHF-------VRLLNNIDR--KLLRS-EDVQMQKQA---LRCI mei-41_Dmel GQIMRFVGSQHVTQFRFKIIAMLSFVHTLQEPRLQRICLKIWHIFLHVVNV---QELGPS ATR_Mmus MSLMKLMGPKHVSSVRVKMMTTLRTGLRFK-DDFPELCCRAWDCFVRCLDH---AYLGPL atl-1_Cele RILLQNMKQDFFDTNWYIILMTLRQ-IPL-N---LDSTQSSWISFIEQINY---SILRSN MEC1_Scer INQMKV------------------------------------------------------ ATR_Hsap MSLMKLMGPKHVSSVRVKMMTTLRTGLRFK-DDFPELCCRAWDCFVRCLDH---ACLGSL ATR_Ddis HRLLGLMGQ-SVDLFRPKIMAFLRLAI--K-TPMEEIAIDAWFTFIQLLKL---DSIGPI ATR_Spur -------------------------------NDFP------------------------- CC1G_08126_Ccin GVFISLVGP-PIHSLSSQIMAIFQTSLSV-A-ELAEVTLESWHEYLVTIDS---KDLGPH AqueK044_Aque ------------------------------------------------------------ ATR_Smoe ERLLEMIGS-HLSAFIPKIMALLSQP-----QDLQYESLSVWLSFVKRLAQVSPANLKTV mei-41_Dmel LGRIVATLQPLLADNES--V---------------------------------KQVNDLY ATR_Mmus LSHVIVALLPLIHMQPKE-------------------------------------TAAIF atl-1_Cele IWRILTDISR----IENNDILIEKVWNRLSYDMVIDKISTDAMIKRVFWLIPLEVEKRID MEC1_Scer ------------NLLKKN-------------------------------------SRQIF ATR_Hsap LSHVIVALLPLIHIQPKE-------------------------------------TAAIF ATR_Ddis LNQIVFSILPFVQSYPEK-------------------------------------SLLIF ATR_Spur ------------------------------------------------------------ CC1G_08126_Ccin LGSTCSAFVS---AWPNLSD---------------------------------RARKIIV AqueK044_Aque ------------------------------------------------------------ ATR_Smoe ASQIVVALMPCLESEQSSTI---------------------------------DAAVQIL mei-41_Dmel EFIILRNASMLGTFITDLYFLDRMEN-----VSPSIQKCIRRHTAHLDLKGLAEEENQSP ATR_Mmus HYLIIENRDAVQDFLHEIYFLPDHPELEK--IKAVLQE-------------YRKETSETT atl-1_Cele LKFEISKSRQIEDVLEFIRMFPQYPSVQF--ADN----LAS------------------- MEC1_Scer AVALVKHGLFSLDIL-ETLFLNRAPTFDKGYITAYL-------------PDYKT-LAEIT ATR_Hsap HYLIIENRDAVQDFLHEIYFLPDHPELKK--IKAVLQE-------------YRKETSEST ATR_Ddis DYLIIKNRTILKPYFKTIPFLPKEY--TV--LKPYIQE-------------LE---SSSA ATR_Spur ------------------------------------------------------------ CC1G_08126_Ccin ESLQLAFGRLKDDLIHYLDDLPDLSIIDD--LKPL--------------HFHLSQLRHPL AqueK044_Aque ------------------------------------------------------------ ATR_Smoe EELILKNRRLLGDQIKELPLLPSLEPLAA--VNAVLNE-------------VR---G-FL mei-41_Dmel PLVDQLRFLQKHITDECLQVRVYALQHLGDLFGRRRPKLNSTILS-ELPLEPMLEQIVNV ATR_Mmus DLQTTLQLSMKAIQHENVDVRIHALTSLKETLYKNQEKLIKYATD-SETVEPVISQLVTV atl-1_Cele ----------------KIERKTVYKEE----------------------LPKLIGSL-SR MEC1_Scer ------------------------------KLYKNS--VTKDAS-DSENANMILCS---- ATR_Hsap DLQTTLQLSMKAIQHENVDVRIHALTSLKETLYKNQEKLIKYATD-SETVEPIISQLVTV ATR_Ddis NLTTQIKQLMELFSNESIEVKLMSTNKLKELLSANKSIIHE-MIQ-LDSDPILINDLVKS ATR_Spur ------------------------------------------------------------ CC1G_08126_Ccin PPRDSLEKLLDRCSSSNLTIATLALEELKRFMQTGDPALLHELLE-DDMFDPMIGRLIST AqueK044_Aque ------------------------------------------------------------ ATR_Smoe SLRDQLLRAGEGLNHESLSLRLVTATELLKLLSSKRNDITALVLRETPADADAVSSLVTR mei-41_Dmel LMAG-CQHD-----DSQLQMASAKCLGELGAIDAS--YLPSNYNFASPQHL----PL--N ATR_Mmus ILKG-CQDA-----NSQARLLCGECLGELGAIDPG--RLDFSTTETQGKDF----TFVTG atl-1_Cele ILPQ-CHS-----KREQNKII--KILQKLPIICSDLPDHNFIRWDTRFKFFCEPRQLTQA MEC1_Scer ------------------------------------------------------------ ATR_Hsap LLKG-CQDA-----NSQARLLCGECLGELGAIDPG--RLDFSTTETQGKDF----TFVTG ATR_Ddis LLIG-CRDP-----YLKLSVNFLTCLGELGAIDPV--KLDFSLRNQSTAEK--------- ATR_Spur ------------------------------------------------------------ CC1G_08126_Ccin VYSAAARDGD---LTESLRLVAYECIGILGALDPY--RFQLPARRADTIVLR---NFTDE AqueK044_Aque ------------------------------------------------------------ ATR_Smoe LLRG-CSEESRTSAGQKFKLACAECLGGLGAIDPV--KLQISLRHRSSMQH--------- mei-41_Dmel ILSDDFAVLAL-TSLCRGYQ-FQQNTKHVDSFSLAIQETLAICGISP-KEQ--------- ATR_Mmus VEDLSFAYGLL-MELTRAYLAYADNSRAQDSAAYAIQELLSIYDCRE-MQS--------- atl-1_Cele VLEDCAGIVEV-------M-TGTSKIEYVDRTMCEIYKFFNPNEASPEMKS--------- MEC1_Scer ------------------------------------------------------------ ATR_Hsap VEDSSFAYGLL-MELTRAYLAYADNSRAQDSAAYAIQELLSIYDCRE-MET--------- ATR_Ddis -DKVQIAAELIEKYLAKFVL-SPSNPTPQDRAGYAIQEILKCCQDT-------------- ATR_Spur ------------------------------------------------------------ CC1G_08126_Ccin NETYQFIINLI-EELVDAFR-STSDMKFQTNLAYPIQELLKLCGFTSDLVN--------- AqueK044_Aque ------------------------------------------------------------ ATR_Smoe -TEEDLVFQLINQHLTRVLR-AASDTDVQDAAALAIQELLKLTGCHE-ARGVSRPPSSSS mei-41_Dmel ----------KKVQLWQSLPARMRQLMEP--MLHSCYTCVHR------------------ ATR_Mmus ---NG-----PGYQLWKRFPEHVREILEP--HLNTRYKSSQK------------------ atl-1_Cele -------------------------TLDGIKNMYAKMICSQK------------------ MEC1_Scer ------------------------------------------------------------ ATR_Hsap ---NG-----PGHQLWRRFPEHVREILEP--HLNTRYKSSQK------------------ ATR_Ddis -------------KLSEKLSNECNDIIKP--YYSSEYMLPLFSKKNNNLVGGGGGNGNGG ATR_Spur ------------------------------------------------------------ CC1G_08126_Ccin ---SGRAVPLRTRNRWAGLKKEVMNAVTP--LLEGRFSFSN------------------- AqueK044_Aque ------------------------------------------------------------ ATR_Smoe KPTQKSKLQ-LGDRLWSRFSDAVKEIISP--CLTSKYLLKV------------------- mei-41_Dmel --P--STCLQQPLFGSHYSHNYYEEWAFLWASRLIDYLPSSG------RRHLLSSYKPCI ATR_Mmus --STDWSGVTKPIYLSKLG-NNFAEWSSSWAGYLITKVRDNL------ASKIFTCCSIMM atl-1_Cele --PEPSMIEQKTIDELSLG-GSRRESFSRWLTVIILKCAEMS------EDAPLSSLASIA MEC1_Scer ------------------------------------------------------------ ATR_Hsap --STDWSGVKKPIYLSKLG-SNFAEWSASWAGYLITKVRHDL------ASKIFTCCSIMM ATR_Ddis GNGVSSSGSSSCFYGS--N-MTYKKWITSWLSDLLFKTKGSPGSANNDLDSIFMACRGII ATR_Spur ------------------------------------------------------------ CC1G_08126_Ccin ----TVPAVKLPVYPT--Q-STYREWLQLWVTHLISRVSGDS------ARKIFGVFQSVV AqueK044_Aque ------------------------------------------------------------ ATR_Smoe ---SGAPMPSGPIFRQ--G-ILFRRWMYLWCRRLLSQVTGQ-------MASILGACRGVV mei-41_Dmel K-RDSNMLSTFYPYILLHALLECTTEQRNHIQEEFMAVLQANEESSSSVRGRQELGAIKE ATR_Mmus K-HDFKVTIYLLPHILVYVLLGCNQEDQQEVYAEIMAVLKHDEQHAIS------------ atl-1_Cele HVDDTRFLSKLAMRFILTVIHMERDSVTQWILSTFEEALTNTNHRRLT------------ MEC1_Scer ------------------------------------------------------------ ATR_Hsap K-HDFKVTIYLLPHILVYVLLGCNQEDQQEVYAEIMAVLKHDDQHTIN------------ ATR_Ddis K-DDLKICHYLLPLVILNIIEYGRESDIQSIKNEILEVLNNNTDL--------------- ATR_Spur ------------------------------------------------------------ CC1G_08126_Ccin RSKDVVLATHLLPHLILNILISGEPDDAEDIRTEIRIVLEDQVDPSST------------ AqueK044_Aque ------------------------------------------------------------ ATR_Smoe R-HDMDAALYILPYLILDIVCHGSQEARTGVTDEILAVLAEAGTGNDGQPGQPV------ mei-41_Dmel NAFKQFESRKYAAGIKPLASTLVSDRKEDSSRVPRLAGKLCAELLDFLQRWLR---EW-Q ATR_Mmus -------------------------TQDSASDLCQLSTQTVFSVLDHLTQWAR---HKFQ atl-1_Cele ----------------------------N-SDR--GPASFVFYVFDFIYSYSSSEELRKK MEC1_Scer ------------------------------------------------------------ ATR_Hsap -------------------------TQDIASDLCQLSTQTVFSMLDHLTQWAR---HKFQ ATR_Ddis -----------------------------STDNGQICTQIIFHVINSLNNWID---VRKR ATR_Spur ------------------------------------------------------------ CC1G_08126_Ccin ----------------------------STHDKKILSAQAIFTLLDHLNRWAH---IMRR AqueK044_Aque ------------------------------------------------------------ ATR_Smoe -----------------------YLNNAFCGSGGEVSMQTVFMLLDNLGQWVD---DS-K mei-41_Dmel R-IHG--RSTGG------KPPE---TI-DSNY-RKIHEFLN--LIPKLLVSRASYNCGEY ATR_Mmus A-LNAE--KLAQNKP------KGVSNVNFEDY-QSVTRFLD--LIPQDTLAVASFRSKAY atl-1_Cele KKIW------------E-------KVISFWKSMMS-WTFKDENGHGQPLIVKVAETFGME MEC1_Scer ------------------------------------------------------------ ATR_Hsap A-LKAE--KCPHSKSNRNKVDSMVSTVDYEDY-QSVTRFLD--LIPQDTLAVASFRSKAY ATR_Ddis KYFLTQQQRTASQKG------KSKKLESPPDV-VVIERFLN--GIPEKILAFASYRCGAL ATR_Spur ------------------------------------------------------------ CC1G_08126_Ccin E-ITTK--QKSETKRARA--S-VALGESQEQL-LRLDSILS--NLDKHLVAKAAFQCKAY AqueK044_Aque ------------------------------------------------------------ ATR_Smoe A-LTSK--GSRSTQA------KELSAKLLVQC-EQVGQLLA--SIPKQSLASASFRCRAY mei-41_Dmel ARALSYLESYLEEGED--KSQRL------------------------------------- ATR_Mmus TRAVMHFESFITEKK-----QNI------------------------------------- atl-1_Cele KRCILWLEMFMEQKRK--TSTEIES----------------------------------- MEC1_Scer ------------------------------------------------------------ ATR_Hsap TRAVMHFESFITEKK-----QNI------------------------------------- ATR_Ddis STSLSYMESLIRNET-----SQILKQQQQQHQLNLQLNMQQQNLQYQQQLQQQQPQQQQQ ATR_Spur ------------------------------------------------------------ CC1G_08126_Ccin ARALMNFEQQIHALKELDNNKNL------------------------------------- AqueK044_Aque ------------------------------------------------------------ ATR_Smoe ARALLYYESYVREKS-----GALNPA---------------------------------- mei-41_Dmel ----------------------------------LEQFTFLVEVYGSLRDPDSVEGAVQV ATR_Mmus ----------------------------------QKHLGFLQKLYAAMHEPDGVAGVSAI atl-1_Cele -------------------------------ETEAAYYFTLMNLYGRIHELNGVRGAYAR MEC1_Scer ------------------------------------------------------------ ATR_Hsap ----------------------------------QEHLGFLQKLYAAMHEPDGVAGVSAI ATR_Ddis QQQQQQQQQVQQQQIPILNSSQPASMASARELALNNNLQLLQKIYHEMDDIDGLIGLSHK ATR_Spur ------------------------------------------------------------ CC1G_08126_Ccin ----------------------------------EPYYDTIHEIYAHLDQPDGMEGITAL AqueK044_Aque ------------------------------------------------------------ ATR_Smoe ------------------------ALVSG--TFKDEDVGFLLKIYGGLDEPDGLLGIARL mei-41_Dmel RS--YDMSVTQDILVNRLVERQQDMITSYEQLLSSTDQMQPD---HVRAMIDAYLRD-TP ATR_Mmus RK--AEPSLKEQILEHESIGLLRDATACYDRAIQ----LEPDQIIHYHGVVKSMLGLGQL atl-1_Cele LSRIQIDHVYGKISMREAFGDFNSAACFARMTGK----GKPFNST------------EAI MEC1_Scer ------------------------------------------------------------ ATR_Hsap RK--AEPSLKEQILEHESLGLLRDATACYDRAIQ----LEPDQIIHYHGVVKSMLGLGQL ATR_Ddis RV--GSPSNEEKIVELESQGFWGDALLYYNTALE----RSPINMDLRIGALNCLFNLGQH ATR_Spur ------------------------------------------------------------ CC1G_08126_Ccin IQ---SPSLEHQIREHESIGQWTSAQSCWEVRLQ----ESPDNLEYHQGLLRCLRNLGHY AqueK044_Aque ------------------------------------------------------------ ATR_Smoe QK---RASLEDQVLINKISGNWAEALTFCEQALE----LEPKSLYWQSGILDCLVNMGHF mei-41_Dmel KTAQLIADGLWQRLSDRY--SDQCFAECKSELLWRLGSYDEMEELQ-------------S ATR_Mmus STVITQVNGVHANRSEW---TDE-LNTYRVEAAWKLSQWDLVENYLAAD-------GKST atl-1_Cele QKLIDELNCLEYSQIERNEQEDY-LNS-----LKTLSQWVNIDNDIGPSPHIF-S-RNIE MEC1_Scer ------------------------------------------------------------ ATR_Hsap STVITQVNGVHANRSEW---TDE-LNTYRVEAAWKLSQWDLVENYLAAD-------GKST ATR_Ddis ESLLLQIEGLKQEPWLTNKDQSK-LGTIKIQSSWRLSHWDKIDETLSQ--------THEP ATR_Spur ------------------------------------------------------------ CC1G_08126_Ccin DTLRNHVKGILTSHPEW---QAD-VIDFHTETLLMVGAWDDVEALVNT--------ADST AqueK044_Aque ------------------------------------------------------------ ATR_Smoe QAMVTHVDGLLARLRDS---RRE-WYMRGVQAAWRLGQWDLINEYVHGSELEAGSTESDS mei-41_Dmel NWPAQCSQGCLKLRRPLTTRIEFDSLLDGMRESVLEELRSCSAV-QQHSYANAYDAVLKL ATR_Mmus TWSVRLGQLLLSAKKRDT--TTFYDTLKLVRAEQIVPL-SAASF-ERGSYQRGYEFIVRL atl-1_Cele YWA-TESTILKMIRNDERDE-IVNNAIENAKSKVIERL-SECAIGGSCSYEIATPFLVEL MEC1_Scer ------------------------------------------------------------ ATR_Hsap TWSVRLGQLLLSAKKRDI--TAFYDSLKLVRAEQIVPL-SAASF-ERGSYQRGYEYIVRL ATR_Ddis NFEAYLGRILYSLVKKQE--KEFNSNLFQCRSFLAQLL-NGSAL---DSYQRCYPYLIQA ATR_Spur -----LSC---------------------------------------------------- CC1G_08126_Ccin SVPVMMAKVMLAMRKGDP--QAISDALSLARLTLGAPI-SAAGV---NGYARSYEAALSL AqueK044_Aque ------------------------------------------------------------ ATR_Smoe AFDLSLAKVLQTLRSKDQ--VKFQEQLTHARLALLAPL-AAASM---ESYVRAYPVIVKL mei-41_Dmel HLVHELHCSQE-LVE----------------KL----EQDRDEDNQEKLMKNYFDDWQYR ATR_Mmus HMLCELEHSLKPLF----------------------RKSPGDSC--N----EDSLNWGAR atl-1_Cele QKLNEIVELKN-VS----------------------NDELSAFN--S----DFWKNIQKR MEC1_Scer ------------------------------------------------------------ ATR_Hsap HMLCELEHSIKPLF----------------------QHSPGDSS--Q----EDSLNWVAR ATR_Ddis HILEEIEQSYK-LIHYNVIPIENVTITNNNNNIGNNNNSNNNNVQKQQMLKKLLSEWDDR ATR_Spur ------------------------------------------------------------ CC1G_08126_Ccin HHLYELELIHN-TTR----------------------NLPSSSTRRKQALTRLSSILADR AqueK044_Aque ------------------------------------------------------------ ATR_Smoe HMLRELEDFFS-LA-----------------------DKGGDNK--D----QLFENWNGR mei-41_Dmel LQIVQPQVRIQESIYSFRRNILAELQRRLTDRNHLLPHLKTELARIWLNSAQINRNAGQL ATR_Mmus LEMTQNSYRAKEPILALRRALLSLNK---------RPDYNEMVGECWLQSARVARKAGHH atl-1_Cele TDDSEQKISILEPILRVRRSMLDIRMQSMTGR--DKENIRSRIVEVHLQSARIARLTGCF MEC1_Scer ------------------------------------------------------------ ATR_Hsap LEMTQNSYRAKEPILALRRALLSLNK---------RPDYNEMVGECWLQSARVARKAGHH ATR_Ddis LKIIQPSFKLRESILSVRREILEIG------------SFSKEVIDCWMKIGKYARHDKKF ATR_Spur ------------------------------------------------------------ CC1G_08126_Ccin LENVLPTFRNLEPILSTRRIGFSLMPG-------TSPDLVKEVGKAWLSSAKVARKAGHW AqueK044_Aque ------------------------------------------------------------ ATR_Smoe LKMTLPSLSTREPILALRRLLFSVC------------DLQSEMGGCWLQYAKLCRTSGHY mei-41_Dmel QRAQLYILKAAEYQP--SGL-FIERAKLLWQKGDQV-MAMNYLEEQLSIMRSGCQG---- ATR_Mmus QTAYNALLNAGESRL--AEL-YVERAKWLWSKGDVH-QALIVLQKGVELCF-----PEN- atl-1_Cele ERAQLSLINAKKVLPFENKI-VLEEAKLQLQTSDEL-NGMSLLDSIISKNFGDLH-TIYT MEC1_Scer ------------------------------------------------------------ ATR_Hsap QTAYNALLNAGESRL--AEL-YVERAKWLWSKGDVH-QALIVLQKGVELCF-----PEN- ATR_Ddis ELSLNAILKPTPSQQ--DKFYFIEHAKLMWNQGHSF-EAINILTQELKNKWNPIINSNNN ATR_Spur ------------------------------------------------------------ CC1G_08126_Ccin PTAYSAILQARQSGT--PLW-FLESAKLMKASGDFIMKAVRELESHMQSLGLISSG---- AqueK044_Aque ------------------------------------------------------------ ATR_Smoe ETANRAILQAQAAGA--PNA-HRERAKLFWDMKKTH-RAIDELQQVLVNVPLSVLG---T mei-41_Dmel -----------------NVKQLAAEQRHLFFRGKY--LQAVYSAESMHLCADAVLKYFQE ATR_Mmus KSP--------------------SESKHMLIHGRATLLVGRFMEETANFESNAVMKKYKD atl-1_Cele D-TQQSVNLDVQKSAKLKIEHY--QEETKNLFSSVQMLRISHMIKAGNTIG--FDKVYHE MEC1_Scer ------------------------------------------------------------ ATR_Hsap ETP--------------------PEGKNMLIHGRAMLLVGRFMEETANFESNAIMKKYKD ATR_Ddis SSNNSSSNININNGSKLSLL--GLPQEDLFIISKTHLLIARWKQQCGITHHSELTEHYSS ATR_Spur ------------------------------------------------------------ CC1G_08126_Ccin -----------------NVLDLTLDDEVVNTKHKLFLWRARWMSESGRFDGTPLLEAFKR AqueK044_Aque ---------------------------------------GKLLEET-DHDSQTILKHYKE ATR_Smoe ASGAALSGLVLNTSQTESALELTVEEQVCNDAAKTLLLLGRWAHCTGQKQKEDVISIYTR mei-41_Dmel AIAVHRQS-ESCHVQMAQFLEKILEARQGGKSEPT---------------GEQDDMLINV ATR_Mmus VTLFLPEW-EDGHFYLAKYYDKLMPMVTDNKMEK------------------QGDLIRYI atl-1_Cele TTQLLQCFAHSGVMYEAAWLLDYLSNYK----E-------------------RSKHVLPL MEC1_Scer --------------------------------------------------------LRFL ATR_Hsap VTACLPEW-EDGHFYLAKYYDKLMPMVTDNKMEK------------------QGDLIRYI ATR_Ddis ATAF--EW-EKGFFFLGRYYDSLLSNLKRVNQNSPNSP--------PLDSVSYVDYTRNI ATR_Spur ------------------------------------------------------------ CC1G_08126_Ccin ATELDKRW-ESSHFYFGNFYDASAKDLKPTDAR-------------------RLKMNMHM AqueK044_Aque VIAIDGEN-EEGHFCLGRYYDRLLTLVEKNPS-------------------NYADVLNYT ATR_Smoe VKDLQPMW-EKGYFYMARYYDDLLVDARKRQEENKEHRSNTTKRGSNADDKPWWTYLPDT mei-41_Dmel MVNYAKSLRYGSEHVYQ--SMPRLISLWLDTTES----------------STNTEQVKKM ATR_Mmus VLHFGRSLQYGNQFIYQ--SMPRMLSLWLDFGAKAYEWE----KGGRSDRLQMRNDLAKI atl-1_Cele LKAYKEVAKYEKNQVLQARAVERMTSLWLSNTRKISTHISSVPKLPEGQISDLRQNIKSM MEC1_Scer ITNFEKDKRHGSKY--------KNINNWTDDQEQAFQKK-------------LQDNILGI ATR_Hsap VLHFGRSLQYGNQFIYQ--SMPRMLTLWLDYGTKAYEWE----KAGRSDRVQMRNDLGKI ATR_Ddis ISSYGQAVILGHSYIYQ--TLTRIIALWCELGVIFSDFK----IPEKSTKV-TSDSLESI ATR_Spur --------------IYQ--I---------------------------------------- CC1G_08126_Ccin LRNYSRATRYGTKFIYQ--TIPRLLTVWLDNGEDK--------------NIFGTDVFNKM AqueK044_Aque IKHYGDALTYGNRFIYH--CLPRALSLWLDYGNSSAS---------KQEKALLQSNVDKI ATR_Smoe VLCYAKTLHRSHHHLFQ--ALPRLLTLWFEFGSAYRS-E----SLGSN-KI-VKAAHVRV mei-41_Dmel NDLLTNC------------------------------------------------CTALP ATR_Mmus NSVLTEH------------------------------------------------TNRLA atl-1_Cele NREIQTA------------------------------------------------LEHIG MEC1_Scer FQVFSSDIHDVEGRTTYYEKLRVINGISFLIIYAPKKSIISALAQISICLQTGLGLKEVR ATR_Hsap NKVITEH------------------------------------------------TNYLA ATR_Ddis KKAMSKL------------------------------------------------ELDVP ATR_Spur ------------------------------------------------------------ CC1G_08126_Ccin NEVVASA------------------------------------------------IKDIP AqueK044_Aque TKLMENL------------------------------------------------VDQLA ATR_Smoe MAIMRGC------------------------------------------------LQELP mei-41_Dmel TAVFYTVYSQMLSRLCHPVNDVFTVLRNVIIKLVEAYPQQSLWMLLPHFKSAKAHRIKRC ATR_Mmus PYQFLTAFSQLISRICHSHDEVFVVLMEIIAKVFLAYPQQAMWMMTAVSKSSYPMRVNRC atl-1_Cele WRAFYPAYAVLARHIDHQDEEVTRTIKQIMKQLILRMPHQCMWQSAYLLRQNIASVKEKY MEC1_Scer YE-AFRCWHLLVRHL--NDEELSTVIDSLIAFILQKWSE--------------------- ATR_Hsap PYQFLTAFSQLISRICHSHDEVFVVLMEIIAKVFLAYPQQAMWMMTAVSKSSYPMRVNRC ATR_Ddis ASNWLMFLSQVASRICHKNTDTWLILEKIIIRTMIEFPKQSIWIMMMQYRSSSSIRKQRA ATR_Spur ------------------------------------------------------------ CC1G_08126_Ccin AYKWFTAFPQIVSRVCHPVDKVYNLVSQLIVSIIQEYPDQALWLFAGVIKSTKHNRLTRG AqueK044_Aque PYQFLIAFSQIISRVCHHDDNVYATLEKIILILLKHYPQHSLWLMIAVSKSS-------- ATR_Smoe SYQWLASLPQLVSRICHDNEEVVRLVKQIIQSVLQAYPQQALWTMAAVSKSDIPERRSAA mei-41_Dmel KLVLTDSRLQNST---FQKLLQDFNSLTERLMDLTNKEVTLDR----------------- ATR_Mmus KEILTKAIHMKKS---LEKFVGDATRLTDKLLELCNKSVDGS----------------NS atl-1_Cele MEVLTEVKRKAPC---YVTLIDQYDYASGVFNTVSGKVESDDCKLSEKVDGLKTMFR-DK MEC1_Scer --------------------------FNGKLRNI---------VYS----ILDTLIKEKS ATR_Hsap KEILNKAIHMKKS---LEKFVGDATRLTDKLLELCNKPVDGS----------------SS ATR_Ddis RTCLEKARKTD-A---IKKNQDETILLCAQLLAVSNHPKKANK---------------RY ATR_Spur ------------------MFTKDAIKLTDRLLDLCNRQVDSG----------------CQ CC1G_08126_Ccin RVILEKAKSSPSSSARISRLISDLHVMANEMLALCEYPVSKEH----------------- AqueK044_Aque ------------------------------------------------------------ ATR_Smoe TEIIQAAKFSTRNDDERATFVQ-FATFIEHMVRLCFAPGASEK---------------AR mei-41_Dmel TYKLSD-LDTRLSKLCKQPEFSQILLPFEKYMQPTLPLNSDSNS--SEGSHLPANQSTVN ATR_Mmus TLSMST-HFKMLKRLVEDPTFSEILIPLQSVMIPTLPSVLG-----AHANH--------D atl-1_Cele KYDPKEL-VMNRRVDCDCKILSGIMVPVRSVIDESVHDTEIRDDGFEESCHLP------- MEC1_Scer DLILKLKPYTTLA-LVGKPE-LGILAPV-------------------------------- ATR_Hsap TLSMST-HFKMLKKLVEEATFSEILIPLQSVMIPTLPSILGTHA--NHASH--------E ATR_Ddis SIKMSE-IFKKLYEMKD----LTVILPLQSSLNVSLPPNGK-----PDKSY--------P ATR_Spur RLSINS-DFRSLKRLLADSNFSKIIVPLQSAMTVTLPSSQS-----VHHTH--------D CC1G_08126_Ccin SLSMPK-LFPRLKAIGE----CSLLIPLLVSLTVSLPSSSS-----AAGTH--------Q AqueK044_Aque -------------------------------LTVTLPACQDAPS-----DH--------N ATR_Smoe SLTLSTSDFSSLKRMMP----LQVIMPVQRALAVTLPADGL-----SNSSY--------N mei-41_Dmel WFP-YQQIYISGFQESVLILRSAAKPKKLTIRCSDGKDYDVLVKPKDDLRRDARLMEFNG ATR_Mmus PFP-GHWAYLAGFDDVVEILSSLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCRLMEFNS atl-1_Cele -----DRYLIHDFSDKVKVLHSNTKPVIIKLTTKTGRIVRLICKKDDDLSKDYHFTKMVE MEC1_Scer -------VSIIRFGSSYKVFSSLKKPKQLNIIGSDGNIYGIMCK-KEDVRQDNQYMQFAT ATR_Hsap PFP-GHWAYIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCRLMEFNS ATR_Ddis AF--GSLPLIGSFEDQIDIMPSLQGPKKINVNDRQGNRYSFLLKPNDDLRKDQRVMEFNT ATR_Spur PFP-LTEVYIIGFDDTVEVLPSLQRPKKIGIQGSDGRLYVMMCKPKDDLRKDNRLMEFNG CC1G_08126_Ccin PFP-DDAPTFKEFSDEIDVMRSMARPRKIWITGSDGGEYIMLIKPKDDLRKDARLMDFDT AqueK044_Aque PFP-GVQPSIVSFDDRVDILNSLQRPKKVIILASDGNRYTMMCKPKDDLRKDCRLMEFNT ATR_Smoe PFPSGDCSTIFAIRDDVEILVSLQRPKKVVLVASDGTEHPFLCKPKDDLRKDARMMEFTG : : . :: * * : : * .: * .:*: :* : .: mei-41_Dmel LVKRYLHQDAPARQRRLHIRTYAVLPFNEECGLVEWLPNLASYRSICMNLYAQRRLVMST ATR_Mmus LINKSLRKDAESRRRELHIRTYAVIPLNDECGIIEWVNNTAGLRPILTKIYKEKGVYMTG atl-1_Cele MCNDLLMKDEQTRIQKMTATTYSVIPLGKQGGIIEFMEGVTSFYETLDKLMGMTSG-EW- MEC1_Scer TMDFLLSKDIASRKRSLGINIYSVLSLREDCGILEMVPNVVTLRSILSTKYESLKIKYSL ATR_Hsap LINKCLRKDAESRRRELHIRTYAVIPLNDECGIIEWVNNTAGLRPILTKLYKEKGVYMTG ATR_Ddis MVNKLIKKDPACRKRNLKIRTYTVIPFNEESGIIEWVSNTATLRSILGGIYETMDT--IG ATR_Spur IINKCLRKNVESRRRELYIRTYTVIPLNEECGLIEWVSNTAGLRPILHKIYREKGLYTSG CC1G_08126_Ccin IINRLLKANADARRRKLYIRTYAVVPLNEECGCIEWVQNTSPLRPILFKYYEARRIKTWT AqueK044_Aque VINK------------------AVIPLSEDSGLVEWVDNTTGYRPILQTTYQEKGMYTSG ATR_Smoe MINRLLSKDPSSRRRKLYIRTFAVIPLTEDCGMVEWVSHTRGLRHILQDLYVSAGMFTKE . :*:.: .: * :* : mei-41_Dmel --RQLQSLAV-PLHESIERK--REVFTKQLVPAHPPVFQEWLRQRFATPHSWYEARNTYI ATR_Mmus --KELRQCML-PKSAALSEK--LKVFQELLLPRHPPVFHEWFLRTFPDPTSWYSSRSAYC atl-1_Cele LE-KLKFWNTHMKPMGKEER--TKYFREVACKNTPVVMGKWFRIQYPEAGQWFASRKLFA MEC1_Scer --KSLHDRW---QHTAVDGK--LEFYME-QVDKFPPILYQWFLENFPDPINWFNARNTYA ATR_Hsap --KELRQCML-PKSAALSEK--LKVFREFLLPRHPPIFHEWFLRTFPDPTSWYSSRSAYC ATR_Ddis ID-RFNQMVN-AKKE--KHY--LDLFED-FNRFFPPVLHKHFITNFPEPSAWLDARDAFA ATR_Spur --SELKAMIP-SLSAPIDEK--LNIFENKLMPRYPPVFGEWFQKTFTDPTSWYLSRLAYA CC1G_08126_Ccin --AELEAQCNKIKDAQAADA--GNIFVKKILPMFPPVFHQWFIETFPDPSAWLENRTNYA AqueK044_Aque --VDVKKLLP-KDSDKRNKKVLKDIFVNKILPRHPPVLGEWFMKAFPDPTSWYSSSQSFA ATR_Smoe TNPTIKRIYE-DNKDKKISA--TELMRDKILPMFPPVFHKWFLNTFPEPTAWFQSRLAYA .. . . * :: : : :. . * : mei-41_Dmel RTVAVMSMVGYILGLGDRHGENILFAEGNGDAVHVDFNCLFNQGELLPYPEVVPFRLTHN ATR_Mmus RSTAVMSMVGYILGLGDRHGENILFDSFTGECVHVDFNCLFNKGETFEVPEIVPFRLTHN atl-1_Cele KSTAVMSVIGYIFGLGDRHTKNLMVH-TTGKCIHVDFDMIFNKGETLGTPELVPFRLTQN MEC1_Scer RSYAVMAMVGHILGLGDRHCENILLDIQTGKVLHVDFDCLFEKGKRLPVPEIVPFRLTPN ATR_Hsap RSTAVMSMVGYILGLGDRHGENILFDSLTGECVHVDFNCLFNKGETFEVPEIVPFRLTHN ATR_Ddis RSCAIMSMVGSVLGLGDRHTENILLDSITGECVHIDYNCLFWKGETFTVPERVPFRLTRN ATR_Spur RTMAVMSMVGYILGLGDRHGENILFDSTNGDCVHVDFNCLFNKGETFDWPERVPFRLTHN CC1G_08126_Ccin RTAAVMSIVGWILGLGDRHCENILLDVITGDAVHIDFNCLFEKGKVLLTPERVPFRLTQN AqueK044_Aque RTAAVMSIVGYMVGLGDRHGENILIDCTNGDVVHVDFSYLFNKGLTLEVPEIVPFRLTHN ATR_Smoe HTTAVWSMVGHIVGLGDRHGENILYDSTTGDCVHVDFSCLFDKGLQLEKPELVPFRLTQN :: *: :::* :.****** :*:: .*. :*:*:. :* :* : ** ****** * mei-41_Dmel MIVAMGPLGVEGSFRKCCEITLRLLKQESKTLMSILRPFVYDVGAQ-----TRKGAATA- ATR_Mmus MVNGMGPMGTEGLFRRACEVTLRLMRDQREPLMSVLKTFLHDPLVE-WSKP-VKGHSKAP atl-1_Cele MINGMGEVALDGEFRTVCEQALRVFRENSYEIEKYIADL-PNLVA-DFPS-NKRAPKDF- MEC1_Scer LLDALGIIGTEGTFKKSSEVTLALMRKNEVALMNVIETIMYDRNMD-HSI---------- ATR_Hsap MVNGMGPMGTEGLFRRACEVTMRLMRDQREPLMSVLKTFLHDPLVE-WSKP-VKGHSKAP ATR_Ddis MVDVFGVLGVEGTFKTVCENTLRVLRSNKEVLLRVLENFIYDPFLILFDKK-NQNSNNNN ATR_Spur MVCAMGPMGYEGVFRRACEGTMKVMRDQRDPLMSVLKTFIYDPLVE-WSKP-SRGRSNA- CC1G_08126_Ccin IVDGLGVTGVEGMFRIACELTMDLLRNNMDSLMSVLDAFIHDPLVE-WEDE-KRKQENRS AqueK044_Aque MVDAMGVTKYEGTFRISCEMTMKLMRQQRDPLMCVLKTLIHDPLVE-WVVKTSRSQSSD- ATR_Smoe MVDGLGITGYEGVFLRTCEITLSVLRANRETLMSVLETFIHDPLVE-WTKS-HKSSATEV :: :* :* * .* :: ::: : : : : : mei-41_Dmel ----------------------KITKDVQRIADRLQGHVKR-----QQANSIPLSTEGQV ATR_Mmus LNETGE---VVNEKA---------KTHVLDIEQRLQGVIKTR----NRVTGLPLSIEGHV atl-1_Cele ----------------------DMSEAKRLVSGRLRGQIMTAKLYRSNPISHPMQVSQLA MEC1_Scer ------------------------QKALKVLRNKIRGI--------DPQDGLVLSVAGQT ATR_Hsap LNETGE---VVNEKA---------KTHVLDIEQRLQGVIKTR----NRVTGLPLSIEGHV ATR_Ddis NTHFGE---VE--------ND-QAVEILKRISATLQGIP---------TVGLQLSIEGQV ATR_Spur LSESGE---INNEKARLNHLKYSALVHVRDIEQRLQGILKIK----NKSRTLPLSIEGHV CC1G_08126_Ccin RRSAQQVPVTTTN---------IAKNALNDIKKKLEGRFTPYTDSQFEQPEKLLSTKNLV AqueK044_Aque ----------------------KGVKIVSDIDERLQGKTG---------KTLP------- ATR_Smoe QNPHAQ---VTGPFGLCIGTDWAFQRALANIEARLRGVVVGV----AAAPSLPLSVEGQA : :.* mei-41_Dmel NFLINEATKVDNLASMYIGWGAFL ATR_Mmus HYLIQEATDENLLCQMYLGWTPYM atl-1_Cele SSLIELATSEEKLSEMYLGWMATL MEC1_Scer ETLIQEATSEDNLSKMYIGWLPFW ATR_Hsap HYLIQEATDENLLCQMYLGWTPYM ATR_Ddis NHLIQEATNPKHLCNMYVGWCSWY ATR_Spur DHLIREATDKKNLCLMYIGWAAYM CC1G_08126_Ccin EALINEASNPMNLSKMYPGWAPWN AqueK044_Aque ---LSEATDIDNLCQMYIGWGPYL ATR_Smoe HRLIQEAVSHENLGHMYVWWMPWF : * . * ** * .