CLUSTAL W (1.83) multiple sequence alignment ak1_Ddis MQPVPSD----PN----------------------------------------------- 10338_Tthe MGQNICVSTK-------------------------------------------------- AlphaK2_Hsap MKDSEG------------------------------------------------------ AlphaK3_Hsap MEVAWLV----YVLGQQPLARQGEGQSRLVPGRGLVLWLPGLPRSSPSWPAVDLAPLAPA AlphaK1_Hsap MNNQKVVAVLLQ------------------------------------------------ AlphaK1_Mmus MNNQDAVASILH------------------------------------------------ AlphaK2_Mmus MTDPGC------------------------------------------------------ AlphaK3_Mmus MGSRRAA----G------------------------------------------------ CC1G_14582_Ccin MSSRQG------------------------------------------------------ CC1G_06337_Ccin MSSRQG------------------------------------------------------ CC1G_14302_Ccin MSQTTC-----P------------------------------------------------ CC1G_08873_Ccin MARCSG------------------------------------------------------ CC1G_12594_Ccin MARCSG------------------------------------------------------ CC1G_11146_Ccin MEPIKQR----S------------------------------------------------ CC1G_00657_Ccin MTPTVEC----P------------------------------------------------ CC1G_02529_Ccin MT---------------------------------------------------------- CC1G_10953_Ccin MT---------------------------------------------------------- CC1G_07428_Ccin MARCSG------------------------------------------------------ * ak1_Ddis ---------------------YGLLRS-LFQD-PN-NQ--------CCA----------- 10338_Tthe ------------------------------------------------------------ AlphaK2_Hsap ----------------------P-QRP-PL-C-FL-ST--------LL------------ AlphaK3_Hsap RPRGPLICHTGHEQAGREPGPGSSTKGPV--L-HDQDT--------RCAFLPRPPGPLQT AlphaK1_Hsap ---------------------ECKQVL-DQ-LLLE-APDVSEEDKSEDQ----------- AlphaK1_Mmus ---------------------ECKQVL-DR-LLLE-TPDVSTEDKSEDQ----------- AlphaK2_Mmus -----------------------PERR-TL-C-FL-ST--------LL------------ AlphaK3_Mmus ------------------------------------------------------------ CC1G_14582_Ccin ------------------------------------------------------------ CC1G_06337_Ccin ------------------------------------------------------------ CC1G_14302_Ccin ---------------------TCHHRF-F--R-LE-NP--------PC------------ CC1G_08873_Ccin ----------------------CSQRF-DL-L-VE-GT--------RCG----------- CC1G_12594_Ccin ----------------------CSQRF-DL-L-VE-GT--------RCG----------- CC1G_11146_Ccin ---------------------MV--------L-L-RSM--------FNA----------- CC1G_00657_Ccin ---------------------LCDQAF-Q--M-PS-GA--------VCG----------- CC1G_02529_Ccin ------------------------------------------------------------ CC1G_10953_Ccin ------------------------------------------------------------ CC1G_07428_Ccin ----------------------CSLRF-EF-L-AE-GM--------RC------------ ak1_Ddis ---------------------------------ECNSA---------------------- 10338_Tthe ------------------------------------------------------------ AlphaK2_Hsap ------------------------------------------------------------ AlphaK3_Hsap RRYCRHQGRQGSGLGAGPGAGTWAPAPPGVSKPRCPGRA----RPGEGQQQVTTARPPAI AlphaK1_Hsap ---------------------------------RCRALLPSELRTLIQ-------EAKEM AlphaK1_Mmus ---------------------------------RCRASLPSELRTLIQ-------EAEEM AlphaK2_Mmus ------------------------------------------------------------ AlphaK3_Mmus ------------------------------------------------------------ CC1G_14582_Ccin ------------------------------------------------------------ CC1G_06337_Ccin ------------------------------------------------------------ CC1G_14302_Ccin ------------------------------------------------------------ CC1G_08873_Ccin ---------------------------------RCTKRAPRP---------------NVE CC1G_12594_Ccin ---------------------------------RCTKRAPRP---------------NVE CC1G_11146_Ccin ---------------------------------KHT------------------------ CC1G_00657_Ccin ---------------------------------RCRKLQGHD-RNSDT-------YRQIM CC1G_02529_Ccin ------------------------------------------------------------ CC1G_10953_Ccin ------------------------------------------------------------ CC1G_07428_Ccin ------------------------------------------------------------ ak1_Ddis ------------------------------------------------------------ 10338_Tthe ------------------------------------------------------------ AlphaK2_Hsap ------------------------------------------------------------ AlphaK3_Hsap NRGARQPRAGAAAAGRGPGAGAWRTGEAAASAGP-------------------------- AlphaK1_Hsap ------------------------------KWPFVPEKWQYKQAVGPEDKTNLKDVIGAG AlphaK1_Mmus ------------------------------KWPFVPEKWQYKQAMSPEDKTNLQDVIGAG AlphaK2_Mmus ------------------------------------------------------------ AlphaK3_Mmus ------------------------------------------------------------ CC1G_14582_Ccin ------------------------------------------------------------ CC1G_06337_Ccin ------------------------------------------------------------ CC1G_14302_Ccin ------------------------------------------------------------ CC1G_08873_Ccin ------------------------------EWGM-------------------------- CC1G_12594_Ccin ------------------------------EWGM-------------------------- CC1G_11146_Ccin ------------------------------------------------------------ CC1G_00657_Ccin ------------------------------SWPQ-------------------------- CC1G_02529_Ccin ------------------------------------------------------------ CC1G_10953_Ccin ------------------------------------------------------------ CC1G_07428_Ccin ------------------------------------------------------------ ak1_Ddis ------------------------------------------------------------ 10338_Tthe -------------------TGDVYKFH--------------------------------- AlphaK2_Hsap ------------------------------------------------------------ AlphaK3_Hsap ----------------AVGEGGAMGSRRAPSRGWGAGGRSGAGGDGEDDGPVWIPSPA-S AlphaK1_Hsap LQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKG--LHKL-----QPA AlphaK1_Mmus LQQLLAALRASILVQDCAAASAIVFLMDRFLYGLDVSGKLLQVAKG--LHKL-----KPA AlphaK2_Mmus ------------------------------------------------------------ AlphaK3_Mmus -------------------------------RGWGLGGRAGAGGDSEDDGPVWTPGPA-S CC1G_14582_Ccin ------------------------------------------------------------ CC1G_06337_Ccin ------------------------------------------------------------ CC1G_14302_Ccin ------------------------------------------------------------ CC1G_08873_Ccin ----------------CNKCGEVFEFMDQ------------------------------- CC1G_12594_Ccin ----------------CNKCGEVFEFMDQ------------------------------- CC1G_11146_Ccin ------------------------------------------------------------ CC1G_00657_Ccin ----------------CVACGACFQNMSLPVNGVQLCGKPGCRDGGEQTGQSQSLTPMGS CC1G_02529_Ccin ------------------------------------------------------------ CC1G_10953_Ccin ------------------------------------------------------------ CC1G_07428_Ccin ------------------------------------------------------------ ak1_Ddis ------------------------------------------------------------ 10338_Tthe ------------------------------------------------------------ AlphaK2_Hsap ---------------------------------------------------SQKVPEKSD AlphaK3_Hsap RSYLLSVRPET---SLSSNRLSHPSSGRSTFCSIIAQLTEETQPLFETTLKSRSVSEDSD AlphaK1_Hsap TPIAPQVVIRQARISVNSGKLLKA------------------------------------ AlphaK1_Mmus TPIAPQVVIRQARVSVNSGKLLKA------------------------------------ AlphaK2_Mmus ---------------------------------------------------SQKVPEKSD AlphaK3_Mmus RSYLLSVRPEA---SLSSNRLSHPSSGRSTFCSIIAQLTEETQPLFETTLKSRAVSEDSD CC1G_14582_Ccin ------------------------------------------------------------ CC1G_06337_Ccin ------------------------------------------------------------ CC1G_14302_Ccin ------------------------------------------------------------ CC1G_08873_Ccin ------------------------------------------------------------ CC1G_12594_Ccin ------------------------------------------------------------ CC1G_11146_Ccin ------------------------------------------------------------ CC1G_00657_Ccin NPIPPSIHINN---SLSNNSLLRSE----------------------------------- CC1G_02529_Ccin ------------------------------------------------------------ CC1G_10953_Ccin ------------------------------------------------------------ CC1G_07428_Ccin ------------------------------------------------------------ ak1_Ddis ------------------------------------------------------------ 10338_Tthe ------------------------------------------------------------ AlphaK2_Hsap AVLRCIISGQPK------PEVTWYKNGQAIDGSGIISNYEFFENQYIHVLHLSCCTKNDA AlphaK3_Hsap VRFTCIVTGYPE------PEVTWYKDDTELDRYCGLPKYEITHQGNRHTLQLYRCREEDA AlphaK1_Hsap ------------------------------------------------------------ AlphaK1_Mmus ------------------------------------------------------------ AlphaK2_Mmus VVLRCMIAGQPK------PEVTWYKNGQAIDLGGTVSSYEFFENQYIHLLHLSCCTQSDA AlphaK3_Mmus VRFTCIVTGYPE------PEVTWYKDDIELDRYCGLPKYEITHQGNRHTLQLYRCQEEDA CC1G_14582_Ccin ------------------------------------------------------------ CC1G_06337_Ccin ------------------------------------------------------------ CC1G_14302_Ccin --PKCR-ARTPGLSSLLVSQL--------------------------------------- CC1G_08873_Ccin ------------------------------------------------------------ CC1G_12594_Ccin ------------------------------------------------------------ CC1G_11146_Ccin ------ITGSPR------V----------------------------------------- CC1G_00657_Ccin ------------------------------------------------------------ CC1G_02529_Ccin ------------------------------------------------------------ CC1G_10953_Ccin ------------------------------------------------------------ CC1G_07428_Ccin --GRCT-NRPAR------DSI--------------------------------------- ak1_Ddis NVPYVCIK--LGVFICPTCAHFLSTLG-FKVRPIMGSSFSEEDISRLQSIGNLVSKQFWL 10338_Tthe --------------------------------HSC------------------------- AlphaK2_Hsap AVYQISAKNSFGMICCSASVEVECSSENPQLSPNL-----EDDRDRG------------- AlphaK3_Hsap AIYQASAQNSKGIVSCSGVLEVGTMTE-YKIHQRW------------------------- AlphaK1_Hsap ------------------------------------------------------------ AlphaK1_Mmus ------------------------------------------------------------ AlphaK2_Mmus AVYQVSARNCVGMICCSASLEVQCLQD-PQVSPDP-----GGGRDAA------------- AlphaK3_Mmus AIYQASARNTKGIVSCSGVLEVGTMTE-YKIHQRW------------------------- CC1G_14582_Ccin ------------------------------------------------------------ CC1G_06337_Ccin ------------------------------------------------------------ CC1G_14302_Ccin ------------------------------------------------------------ CC1G_08873_Ccin ------------------------------------------------------------ CC1G_12594_Ccin ------------------------------------------------------------ CC1G_11146_Ccin ------------------------------------------------------------ CC1G_00657_Ccin ------------------------------------------------------------ CC1G_02529_Ccin ------------------------------------------------------------ CC1G_10953_Ccin ------------------------------------------------------------ CC1G_07428_Ccin ------------------------------------------------------------ ak1_Ddis ARWTPMDIVMPPPEDPNLESFLRLKYIEKRWTSSL---STSD----G-F-----SSPNN- 10338_Tthe ---FAEGS---------SRKA--------------------------------------- AlphaK2_Hsap --WKHETG---------THEEERANQIDEKEHPYKEEESISPGTPRSADS-----SPSKS AlphaK3_Hsap ---FAKLK---------RKAAAKLREIEQSWKHEKA---VPG----EVDT-LRKLSPDRF AlphaK1_Hsap ------------------------------------------------------------ AlphaK1_Mmus ------------------------------------------------------------ AlphaK2_Mmus --GECKTE---------IREEDSINHTDEKWNPCKKGES-------TADS-----FLDKF AlphaK3_Mmus ---FAKLK---------RKAAAKMREIEQSWKHGKE---ASG----EADTLLRKISPDRF CC1G_14582_Ccin ------------------------------------------------------------ CC1G_06337_Ccin ------------------------------------------------------------ CC1G_14302_Ccin ------------------------------------------------------------ CC1G_08873_Ccin ------------------------------------------------------------ CC1G_12594_Ccin ------------------------------------------------------------ CC1G_11146_Ccin -----------------------------------------------------------F CC1G_00657_Ccin ------------------------------------------------------------ CC1G_02529_Ccin ------------------------------------------------------------ CC1G_10953_Ccin ------------------------------------------------------------ CC1G_07428_Ccin ------------------------------------------------------------ ak1_Ddis ----------------NNTSNVNNINNNSNHNNNINNNNNNINN-----NNNNNINNNNN 10338_Tthe ------------------------------------------------------------ AlphaK2_Hsap NHSLSLQSLGNLDISVSSSENPLGVKGTRHTGEAYDPSNTEEIANGLLFLNSSHIYEKQD AlphaK3_Hsap QRKRRLSGAQAPGPSVPTREPEGGTLAA-------------------------------- AlphaK1_Hsap ----------------------------EYILSSLISNNGATGT-----WLYRNESDKVL AlphaK1_Mmus ----------------------------EYILSSLISNNGATGT-----WLYRNESDKVL AlphaK2_Mmus NHLSSPQIVARGDSGASNSENPQYIKETRQRMGQYNSNNMQENS-----FNSNNTAEKQD AlphaK3_Mmus QRKRRLSGVEEAVLSTPVREMEEGSSAA-------------------------------- CC1G_14582_Ccin ------------------------------------------------------------ CC1G_06337_Ccin ------------------------------------------------------------ CC1G_14302_Ccin ------------------------------------------------------------ CC1G_08873_Ccin ------------------------------------------------------------ CC1G_12594_Ccin ------------------------------------------------------------ CC1G_11146_Ccin QTETY-------------LNQEGGITIE-------------------------------- CC1G_00657_Ccin ---------------------------E-------------------------------- CC1G_02529_Ccin ------------------------------------------------------------ CC1G_10953_Ccin ------------------------------------------------------------ CC1G_07428_Ccin ------------------------------------------------------------ ak1_Ddis IINNFSNINNISNGMNNISLN--NINNNNNNNNHYNGNDIGIPIVHKTQSQPQPQPQPQP 10338_Tthe ------------------------------------------------------------ AlphaK2_Hsap R-CCHKTVHSMASKFTDGDLN--NDGPHDEGLR------SSQ-----------------Q AlphaK3_Hsap ---------------------------WQEGET------ETA-----------------Q AlphaK1_Hsap ----VQSVCIQIRGQILQKLGMWYE-AAELIWASI-----VG-----YLALPQPD----- AlphaK1_Mmus ----VQSVCIQIRGQILQKLGMWYE-AAELIWASV-----IG-----YLTLPQPD----- AlphaK2_Mmus V-SQLWTVNATVPGLVSDGLG--YE-ESNESVS------PSH-----------------Q AlphaK3_Mmus ---------------------------WQEGET------ESA-----------------Q CC1G_14582_Ccin ------------------------------------------------------------ CC1G_06337_Ccin ------------------------------------------------------------ CC1G_14302_Ccin ------------------------------------------------------------ CC1G_08873_Ccin ------------------------------------------------------------ CC1G_12594_Ccin ------------------------------------------------------------ CC1G_11146_Ccin ---------------------------GGQMGLTLKQYVDRL-----------------R CC1G_00657_Ccin ---------------------------FRNRIR------ARS-----------------R CC1G_02529_Ccin ------------------------------------------------------------ CC1G_10953_Ccin ------------------------------------------------------------ CC1G_07428_Ccin ------------------------------------------------------------ ak1_Ddis QPQSQGFSPFNSPRSSPKPGRHHLIDDLISFNPTPVN-NSNNNNNN---NNNNNNGNNGN 10338_Tthe ---------------------------------------------------YR---CEV- AlphaK2_Hsap NPKVQKYISFSLPLSEATAHIYPGDSAVANKQPSPQL-SSEDSDSDYELCPEITLT---Y AlphaK3_Hsap HSGLGLINSFA-----------SGE-VTTNGEAAPEN-GEDG---EHGLLTYI---CDAM AlphaK1_Hsap ---KKGLST------------------SLGILADIFVSMSKNDYEKFKNNPQINLS---L AlphaK1_Mmus ---KKGIST------------------SLGILADIFVSMSKTDYEKFKKSPKVNLA---L AlphaK2_Mmus TPKVQKYISFSLPLPETTLGPYPEDSNSINMQPGPQV-SSEDSDSDYELCPEITLT---Y AlphaK3_Mmus HPGLGLINSFA-----------PGE-APTNGEPAPEN-GEDE---ERGLLTYI---CEVM CC1G_14582_Ccin ------------------------------------------------------------ CC1G_06337_Ccin ------------------------------------------------------------ CC1G_14302_Ccin --------------------------------------------NEKPQCSGCGVYGDLP CC1G_08873_Ccin ------------------------------------------------------------ CC1G_12594_Ccin ------------------------------------------------------------ CC1G_11146_Ccin DDGWITVPTMS------------------------------------------------- CC1G_00657_Ccin PEVIVATTRLS-----------S------------------------------------- CC1G_02529_Ccin ------------------------------------------------------------ CC1G_10953_Ccin ------------------------------------------------------------ CC1G_07428_Ccin --------------------------------------------DDWGLCRRCGSV---Y ak1_Ddis PLK--------------------------------------------------------- 10338_Tthe ------------------------------------------------------------ AlphaK2_Hsap TEEFSDDDLE-------------------------YLECS-DVM---------------- AlphaK3_Hsap E--LGPQRALKEESGAKKKKKDEESKQGLRKPELEKAAQSRRSS---------------- AlphaK1_Hsap LKEFDHHLLS-------------------------AAEAC-KLAAAFSAYTPLFVLTAVN AlphaK1_Mmus LKEFDHHLLS-------------------------ASEAC-KLAAAFSAYTPLFVLTAVN AlphaK2_Mmus TEEFSDDDLE-------------------------YLECS-DVM---------------- AlphaK3_Mmus E--LGPQNSPPKESGAKKKRKDEESKPGEQKLELEKAEGSQCSS---------------- CC1G_14582_Ccin ------------------------------------------------------------ CC1G_06337_Ccin ------------------------------------------------------------ CC1G_14302_Ccin TL---------------------------------------------------------- CC1G_08873_Ccin ------------------------------------------------------------ CC1G_12594_Ccin ------------------------------------------------------------ CC1G_11146_Ccin ------------------------------------------------------------ CC1G_00657_Ccin ------------------------------------------------------------ CC1G_02529_Ccin ------------------------------------------------------------ CC1G_10953_Ccin ------------------------------------------------------------ CC1G_07428_Ccin EH---------------------------------------------------------- ak1_Ddis --------------FS-------------------------------------------- 10338_Tthe ------------------------------------------------------------ AlphaK2_Hsap ------------TDYSNAVWQRNLLGTEHVFLLESDDEEMEFGEHCLGGCEHFLSGM--- AlphaK3_Hsap ------------E-----------------NCIPSSDEPDSCGTQGPVGVEQVQTQPRGR AlphaK1_Hsap IRGTCLLSYSSSN-----------------DCPPELKNLHLC------------------ AlphaK1_Mmus IRGTCLLSYSCSA-----------------DCPPGMKSVHLC------------------ AlphaK2_Mmus ------------TDYSNAVWQRSLQGTDRVFLLESDDEEMEFNECGLGGCEHFFTEM--- AlphaK3_Mmus ------------E-----------------NVVPSTDKPNSSRREKSTDTQPAQTQPRGR CC1G_14582_Ccin ------------------------------------------------------------ CC1G_06337_Ccin ------------------------------------------------------------ CC1G_14302_Ccin ---------------------------------------SN-GPLCN-LCVAFY------ CC1G_08873_Ccin -------------------------------------------NVCF-DCSKYT------ CC1G_12594_Ccin -------------------------------------------NVCF-DCSKYT------ CC1G_11146_Ccin ------------------------------------------------------------ CC1G_00657_Ccin ------------------------------------------------------------ CC1G_02529_Ccin ------------------------------------------------------------ CC1G_10953_Ccin ------------------------------------------------------------ CC1G_07428_Ccin ---------------------------------------LE-GEICF-DCEKYT------ ak1_Ddis --------------------------------------------GGIPQNNNNNNNNNTT 10338_Tthe --------------VKGPNLG--------------------------------------- AlphaK2_Hsap ---GCG---------SR------------------------------------------- AlphaK3_Hsap AARGPGSSGTDSTRKPASAVGTPDKAQKAPGPGP-------------------------G AlphaK1_Hsap ------------EAKEAFEIGLLTKRDDEPVTG--------------------------K AlphaK1_Mmus ------------EAKEAFEIGLLTKKDGELVSG--------------------------K AlphaK2_Mmus ---GCG---------PQ------------------------------------------- AlphaK3_Mmus VARGPGI---ESTRKTASVLGIQDKVQDVPAPAPAPVPAPALAPAPVPVPAPTPVPSRSS CC1G_14582_Ccin ------------------------------------------------------------ CC1G_06337_Ccin ------------------------------------------------------------ CC1G_14302_Ccin ------------------------------------------------------------ CC1G_08873_Ccin ------------------------------------------------------------ CC1G_12594_Ccin ------------------------------------------------------------ CC1G_11146_Ccin ---------------SAKPVGF-------------------------------------- CC1G_00657_Ccin ------------------------------------------------------------ CC1G_02529_Ccin ------------------------------------------------------------ CC1G_10953_Ccin ------------------------------------------------------------ CC1G_07428_Ccin ------------------------------------------------------------ ak1_Ddis TTTTTTNNNN-------------------------------------------------- 10338_Tthe ------------------------------------------------------------ AlphaK2_Hsap ---------------------VSGDAGPMVATAGFCGHHSQPQEVGVRSSRVSKHGPSSP AlphaK3_Hsap QEVYF--SLKDMYLENTQAVRPLG--------------EEGPQTLSVRAPGESPKGKAPL AlphaK1_Hsap QELHS--FVKAAFGLTTVHRRL---------------------------HGETGTV---- AlphaK1_Mmus QELHS--FIKAAFGLTTVHSRL---------------------------HGETDAV---- AlphaK2_Mmus ---------------------VSGGMWSMNVATGFCSYHSQPQEVRVRSSGTSGHSPLPL AlphaK3_Mmus EQVYF--SLKDMFMETTRAGRSQE--------------EEKPPPPSTRVAGESPPGKTPV CC1G_14582_Ccin ------------------------------------------------------------ CC1G_06337_Ccin ------------------------------------------------------------ CC1G_14302_Ccin -----------------------KAG-------------------GSA--P--------- CC1G_08873_Ccin -----------------------AGN-------------------GVQQAS--------- CC1G_12594_Ccin -----------------------AGN-------------------GVQQAS--------- CC1G_11146_Ccin ------------------------------------------------------------ CC1G_00657_Ccin ----------------------------------------------AALHERENALRQEI CC1G_02529_Ccin ------------------------------------------------------------ CC1G_10953_Ccin ------------------------------------------------------------ CC1G_07428_Ccin -----------------------GDD-------------------GAQQLA--------- ak1_Ddis ----------------------------KVPFDPFSPIKTF------------------- 10338_Tthe ------------------KKGVVKR----------------------------------- AlphaK2_Hsap QTGMTLILGPHQDGTSSVT----------------------------------------E AlphaK3_Hsap RARSEGVPGAPGQPTHSLTPQPTRPFNRKRFAPPKPKGEATTDSKPISSLSQAPECGAQS AlphaK1_Hsap -------------------HAAS-----QLCKEAMGKLYNFST----SSRSQDREALSQE AlphaK1_Mmus -------------------RAAR-----QLCSEAVGKLYTFST----SPTSQDREGLSQE AlphaK2_Mmus HSEMTLTLGPHQDETAKMT----------------------------------------E AlphaK3_Mmus KSRLEKVPMVSSQPTSSMVPPPIKPLNRKRFAPPKSKVESTTT----SLSSQTSESMAQS CC1G_14582_Ccin ------------------------------------------------------------ CC1G_06337_Ccin ------------------------------------------------------------ CC1G_14302_Ccin ------------------------------------------------------------ CC1G_08873_Ccin ------------------------------------------------------------ CC1G_12594_Ccin ------------------------------------------------------------ CC1G_11146_Ccin ------------------------------------------------------------ CC1G_00657_Ccin A-----------------DAASVSRAQITI-------VY--------------------- CC1G_02529_Ccin ------------------------------------------------------------ CC1G_10953_Ccin ------------------------------------------------------------ CC1G_07428_Ccin ------------------------------------------------------------ ak1_Ddis ------------------------------------------------------------ 10338_Tthe --------YKNHIENKKLDNFKNE------------------------------------ AlphaK2_Hsap QGRYKL--------------------------------PTAPEAAENDYPGIQGETR--D AlphaK3_Hsap LGKA-P--------------------------------PQASVQVPTPPARRRHGTR--D AlphaK1_Hsap VMSV-IAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLI-------------LHGQGDFQ AlphaK1_Mmus IMSL-ISQVKGHLRVQSFPNLDACSYVPESFKCGLDRLI-------------LHGHVDFQ AlphaK2_Mmus PGRAPL--------------------------------PTAPEAVENDCSGIRGETR--D AlphaK3_Mmus LGKA-L--------------------------------PSASTQVPTPPARRRHGTR--D CC1G_14582_Ccin ------------------------------------------------------------ CC1G_06337_Ccin ------------------------------------------------------------ CC1G_14302_Ccin ------------------------------------------------------------ CC1G_08873_Ccin ------------------------------------------------------------ CC1G_12594_Ccin ------------------------------------------------------------ CC1G_11146_Ccin ------------------------------------------------------------ CC1G_00657_Ccin ------------------------------------------------------------ CC1G_02529_Ccin ------------------------------------------------------------ CC1G_10953_Ccin ------------------------------------------------------------ CC1G_07428_Ccin ------------------------------------------------------------ ak1_Ddis ------------------------------------------------------------ 10338_Tthe ------------------------------------------------------------ AlphaK2_Hsap SHQAREEFA-SDNLLNMDESVRETEMKLLSGESENSGMSQCWETAADKRVGGKDLWSKRG AlphaK3_Hsap STLQGQAGH-RTPG---------------------------------------------- AlphaK1_Hsap KILDTYSQHHTSVC---------------------------------------------- AlphaK1_Mmus QILETYSQHHTSVC---------------------------------------------- AlphaK2_Mmus NPEAGEEFS-GDNLQTMDKVETEASVKPLSGGSDKTEVKQGLESLARERTDEKYPGSKKA AlphaK3_Mmus SPLQGQTSH-KTPG---------------------------------------------- CC1G_14582_Ccin ------------------------------------------------------------ CC1G_06337_Ccin ------------------------------------------------------------ CC1G_14302_Ccin ------------------------------------------------------------ CC1G_08873_Ccin ------------------------------------------------------------ CC1G_12594_Ccin ------------------------------------------------------------ CC1G_11146_Ccin -------GK-KRTG---------------------------------------------- CC1G_00657_Ccin ---AFRQST-NWKQ---------------------------------------------- CC1G_02529_Ccin ------------------------------------------------------------ CC1G_10953_Ccin ------------------------------------------------------------ CC1G_07428_Ccin ------------------------------------------------------------ ak1_Ddis ---------------------------SESGEYQNTNGNQQLSGSGN------------- 10338_Tthe ------------------------------------------------------------ AlphaK2_Hsap SRKSARVRQPGMKGNPKKPNANLRES------------------------TTEGTLHLCS AlphaK3_Hsap ------------------------------------------------------------ AlphaK1_Hsap ------------------------------------------------------------ AlphaK1_Mmus ------------------------------------------------------------ AlphaK2_Mmus ALRPTRARRPGMKANTKK--QLLRDS------------------------APKGTLDLL- AlphaK3_Mmus ------------------------------------------------------------ CC1G_14582_Ccin ------------------------------------------------------------ CC1G_06337_Ccin ------------------------------------------------------------ CC1G_14302_Ccin ---------LELLQDPRASQQLLAASADGSA-ATNP-QSQQLLERAL------------- CC1G_08873_Ccin ---------REAIANPVNVRTHTNSGGGTSAQFQG-AGNQQLQEEAL------------- CC1G_12594_Ccin ---------REAIANPVNVRTHTNSGGGTSAQFQG-AGNQQLQEEAL------------- CC1G_11146_Ccin ------------------------------------------------------------ CC1G_00657_Ccin ------------------------------------------------------------ CC1G_02529_Ccin ------------------------------------------------------------ CC1G_10953_Ccin ------------------------------------------------------------ CC1G_07428_Ccin ---------KNAIANPVDPRKHTLPGGRSSSAESDV-Q--AIDPEAYAKAK--------- ak1_Ddis ------SLIDILSHP-TQSKSP------------SPSGTPHSLSPQHHSS--DFKVHLID 10338_Tthe ------------------------------------------------------------ AlphaK2_Hsap AKESAEPPL-TQSDKRETSHTTAAATG----RSS------------------HADA-REC AlphaK3_Hsap ------------------------------------------------------------ AlphaK1_Hsap ------------------------------------------------------------ AlphaK1_Mmus ------------------------------------------------------------ AlphaK2_Mmus PKEPTRQPL-PGSYGQEPTHTEAGAPG----WDS------------------HFHA-EVC AlphaK3_Mmus ------------------------------------------------------------ CC1G_14582_Ccin ------------------------------------------------------------ CC1G_06337_Ccin ------------------------------------------------------------ CC1G_14302_Ccin ------SYQQSASGT-RLGQK--------------PRV-----------T--------GT CC1G_08873_Ccin ------RIMSSMSHS-YTDAHARTS-GTRFQGRIAPSK-----------LKLKTAA-ELG CC1G_12594_Ccin ------RIMSSMSHS--------------FQGRIAPSK-----------LKLKTAA-ELG CC1G_11146_Ccin ------------------------------------------------------------ CC1G_00657_Ccin ------------------------------------------------------------ CC1G_02529_Ccin ------------------------------------------------------------ CC1G_10953_Ccin ------------------------------------------------------------ CC1G_07428_Ccin ----AEVALSRMRNG-YADAMARAAPG----VKVARSK-----------L--KGSL---- ak1_Ddis -IPTTQQQ-----------------L-------------------QQQQLQLQQQLQQQL 10338_Tthe ------------------------------------------------------------ AlphaK2_Hsap AISTQAEQEAKT-LQTSTDSVSKEGNTNCKGEGMQVNTLFETSQVPDWSDPPQVQVQETV AlphaK3_Hsap --EV-------LECQTT--------------------------TA--------------- AlphaK1_Hsap --EV-------FESDCG--------------------------NN--------------- AlphaK1_Mmus --EV-------FESTCG--------------------------NS--------------- AlphaK2_Mmus -IPLPAEQDSKI-LRPPADPLSKEEDSSFEGGGALLNKLFEASQIPDRTDHLQMQIQETI AlphaK3_Mmus --EA-------LESPAT--------------------------VA--------------- CC1G_14582_Ccin ------------------------------------------------------------ CC1G_06337_Ccin ------------------------------------------------------------ CC1G_14302_Ccin -GPNPV------------------------------------------------------ CC1G_08873_Ccin -I---------------------------------------------------------- CC1G_12594_Ccin -I---------------------------------------------------------- CC1G_11146_Ccin --P--------------------------------------------------------- CC1G_00657_Ccin --ED-------GTLGSG--------------------------EI--------------- CC1G_02529_Ccin ------------------------------------------------------------ CC1G_10953_Ccin ------------------------------------------------------------ CC1G_07428_Ccin ------------------------------------------------------------ ak1_Ddis QQQQQQQQQQQQQQQSPISNPFT------------------------SNNNSNSEPLVSI 10338_Tthe ------------------------------------------------------------ AlphaK2_Hsap RETISCSQMPAFSEPAGEESPFT------------------------GTTTISFSNLGGV AlphaK3_Hsap --------------------PTMSASSSSDVA--SIGVSTSGSQGIIEP----------- AlphaK1_Hsap --------------------KNEQKDAKTGVCITAL------------------------ AlphaK1_Mmus --------------------KRNQRDTKSEVCITTL------------------------ AlphaK2_Mmus GESSSLDQMLAFSVPAEESSTFA------------------------GATTHSVSNLSEI AlphaK3_Mmus --------------------PTKSANSSSDTV--SVDHDSSGNQGATEP----------- CC1G_14582_Ccin ------------------------------------------------------------ CC1G_06337_Ccin ------------------------------------------------------------ CC1G_14302_Ccin ----------------------------------------------------LFSNLAKA CC1G_08873_Ccin ------------------------------------------------------------ CC1G_12594_Ccin ------------------------------------------------------------ CC1G_11146_Ccin ------------------------------------------------------------ CC1G_00657_Ccin --------------------PFD------------------------AH----------- CC1G_02529_Ccin ------------------------------------------------------------ CC1G_10953_Ccin ------------------------------------------------------------ CC1G_07428_Ccin ------------------------------------------------------------ ak1_Ddis LDKHEDLHNHHHHQQQQHHKQQQQQQQQQQNGNNSP----LAQ-FNQIQQQQINNN---- 10338_Tthe ------------------------------------------------------------ AlphaK2_Hsap HKENASLAQHSEVKP-------------------------CTCGPQHEEKQ--------- AlphaK3_Hsap ----------------------------------------MDMETQEDGRTSANQRTGSK AlphaK1_Hsap ---------------------------KTEIKNIDTVSTTQEKPHCQRDTGISSSLMG-- AlphaK1_Mmus ---------------------------KTETNTADTMVATLERVSSQDSRSTASSKMS-- AlphaK2_Mmus NRENLSLAQYPGLES-------------------------CPQSLQQEGRP--------- AlphaK3_Mmus ----------------------------------------MDTETQEDGRTLVDGRTGSR CC1G_14582_Ccin ------------------------------------------------------------ CC1G_06337_Ccin ------------------------------------------------------------ CC1G_14302_Ccin HQYNAAKKASLE---------------------------------REKNKK--------- CC1G_08873_Ccin ------------------------------------------------------------ CC1G_12594_Ccin ------------------------------------------------------------ CC1G_11146_Ccin ------------------------------------------------------------ CC1G_00657_Ccin ----------------------------------------K-----TLSVKR-------- CC1G_02529_Ccin ------------------------------------------------------------ CC1G_10953_Ccin ------------------------------------------------------------ CC1G_07428_Ccin ------------------------------------------------------------ ak1_Ddis ------------------------------------------------------------ 10338_Tthe ------------------------------------------------------------ AlphaK2_Hsap ------------------------------------------------------------ AlphaK3_Hsap KNVQADGKIQVDGRTRGDGTQ----TAQRTRADRKTQVDAGTQESKRPQSDRSAQKGMMT AlphaK1_Hsap --KNVQRELRRGG----------------------------------------------- AlphaK1_Mmus --KKDQGKLQRER----------------------------------------------- AlphaK2_Mmus ------------------------------------------------------------ AlphaK3_Mmus KKTHTDGKLQVDGRTQGDGAQDRAHASPRTQAGEKAPTDVVTQGSERPQSDRSSWKNLVT CC1G_14582_Ccin ------------------------------------------------------------ CC1G_06337_Ccin ------------------------------------------------------------ CC1G_14302_Ccin ------------------------------------------------------------ CC1G_08873_Ccin ------------------------------------------------------------ CC1G_12594_Ccin ------------------------------------------------------------ CC1G_11146_Ccin ------------------------------------------------------------ CC1G_00657_Ccin ------------------------------------------------------------ CC1G_02529_Ccin ------------------------------------------------------------ CC1G_10953_Ccin ------------------------------------------------------------ CC1G_07428_Ccin ------------------------------------------------------------ ak1_Ddis --------------------------NPFVEEKQPHQHPHHLQHHRH------HST---S 10338_Tthe ------------------------------------------------------------ AlphaK2_Hsap -------------------DRDGNIPDNFRE-------------DLKYEQSISE------ AlphaK3_Hsap QGRAETQLETTQAGEKIQEDRKAQADKGTQE-------------DR--------RM---- AlphaK1_Hsap -------------RRNWTHS-------------------------DAF------RVSLDQ AlphaK1_Mmus -------------GRSWTHS-------------------------KAF------RVSLDL AlphaK2_Mmus -------------------NRDRDLPGALWA-------------ESACELSLLE------ AlphaK3_Mmus QRRVDMQVGQMQAGERWQQD-------------------------PGD-----ARI---- CC1G_14582_Ccin ------------------------------------------------------------ CC1G_06337_Ccin ------------------------------------------------------------ CC1G_14302_Ccin ----------------------------VAI-------------RISSTLYLS------- CC1G_08873_Ccin ------------------------------------------------------------ CC1G_12594_Ccin ------------------------------------------------------------ CC1G_11146_Ccin ------------------------------------------------------------ CC1G_00657_Ccin ------------------------VNDEWGK-------------EG-N-----FKA---I CC1G_02529_Ccin ------------------------------------------------------------ CC1G_10953_Ccin ------------------------------------------------------------ CC1G_07428_Ccin ------------------------------------------------------------ ak1_Ddis SINHGSNGDL------ASISLTL------------------------LTPSPSPSPSFNY 10338_Tthe ------------------------------------------------------------ AlphaK2_Hsap ---------------ANDETM-SPGVFSRHLPKDARADFREPVAVSVASPEP-------- AlphaK3_Hsap Q--------GEKGMQGEKGTQSE-G-----------SAPTAMEGQSEQEVAT-------- AlphaK1_Hsap DVETET------------------------------------------------EP-SDY AlphaK1_Mmus DMETET------------------------------------------------EP-PNH AlphaK2_Mmus ---------------DNEEEE-SQPPASVALPQGDGVPCREPEGLSDSFPQP-------- AlphaK3_Mmus Q--------E-----EEKETQSAAG-----------SIPVAFETQSEQLSMA-------- CC1G_14582_Ccin ------------------------------------------------------------ CC1G_06337_Ccin ------------------------------------------------------------ CC1G_14302_Ccin --------------------------------NHKGLRPVPGTREGHTFIQ--------- CC1G_08873_Ccin ------------------------------------------------------------ CC1G_12594_Ccin ------------------------------------------------------------ CC1G_11146_Ccin ------------------------------------------------------------ CC1G_00657_Ccin Y--------M-------EETDLRR------------------------------------ CC1G_02529_Ccin ------------------------------------------------------------ CC1G_10953_Ccin ------------------------------------------------------------ CC1G_07428_Ccin ------------------------------------------------------------ ak1_Ddis SGGVSSAPN----N---------------------------------------------- 10338_Tthe ------------------------------------------------------------ AlphaK2_Hsap -------TDTALTLENVCDEPRDREAVCAMECFEAGDQGTCFDTIDSLVGRPVDKYSPQE AlphaK3_Hsap -------SLGPPSRTPKLPPTAGPRAPLNIECFVQTPEGSCFPKKPGCLPRS-------- AlphaK1_Hsap SNGEGAVFN----K---------------------------------------------- AlphaK1_Mmus SNGGTDVFN----K---------------------------------------------- AlphaK2_Mmus -------TAPSLPLENVGSGSRVREAAGGVGCFEAGDQETCYATMDLLVGAPVDKYLPQE AlphaK3_Mmus -------SLSSLPGALKGSPSGCPRESQAIECFEKSTEAPCVQERSDLMLRS-------- CC1G_14582_Ccin ------------------------------------------------------------ CC1G_06337_Ccin ------------------------------------------------------------ CC1G_14302_Ccin --------PA------------------------------------------ATKVVEGY CC1G_08873_Ccin ------------------------------------------------------------ CC1G_12594_Ccin ------------------------------------------------------------ CC1G_11146_Ccin ------------------------------------------------------------ CC1G_00657_Ccin ------------------------------------------------------------ CC1G_02529_Ccin ------------------------------------------------------------ CC1G_10953_Ccin ------------------------------------------------------------ CC1G_07428_Ccin ------------------------------------------------------------ ak1_Ddis -------------SLNNSCNGNNNL----------------------------------- 10338_Tthe ------------------------------------------------------------ AlphaK2_Hsap ICSVDTELAEGQNKVSDLCSSNDKTLEVFFQTQVSETSVSTCKSSKDGNSVMSPLFTSTF AlphaK3_Hsap -----------------------------------EEAVVTAS-RNHEQTVLGPLSGN-- AlphaK1_Hsap -------------SLS-------------------------------------------- AlphaK1_Mmus -------------SLR-------------------------------------------- AlphaK2_Mmus ICPEDLELTEGQSEVCDLCS-PDKILAV-LQTQGSEPPRSTDKRSQDGKSAEGLLFNSTF AlphaK3_Mmus -----------------------------------EEA---AF-RSHEDGLLGPPSGN-- CC1G_14582_Ccin ------------------------------------------------------------ CC1G_06337_Ccin ------------------------------------------------------------ CC1G_14302_Ccin ACLLGR------------------------------------------------------ CC1G_08873_Ccin ------------------------------------------------------------ CC1G_12594_Ccin ------------------------------------------------------------ CC1G_11146_Ccin ------------------------------------------------------------ CC1G_00657_Ccin ------------------------------------------------------------ CC1G_02529_Ccin ------------------------------------------------------------ CC1G_10953_Ccin ------------------------------------------------------------ CC1G_07428_Ccin ------------------------------------------------------------ ak1_Ddis --------------------------N--------------------------------- 10338_Tthe ------------------------------------------------------------ AlphaK2_Hsap TLNISHTASEGATGENLAKVENSTYPLASTV--------------------HAGQEQPSP AlphaK3_Hsap ----------------------------LMLPAQPPHEGSVEQVGGERCRGPQSSG---- AlphaK1_Hsap ------------------------------------------------------------ AlphaK1_Mmus ------------------------------------------------------------ AlphaK2_Mmus TWDTAKEASEDAVGETAADVENPPSTFSSTL----------------------------P AlphaK3_Mmus ----------------------------RTYPTQLPPEGHSEHLGGQ--------T---- CC1G_14582_Ccin ------------------------------------------------------------ CC1G_06337_Ccin ------------------------------------------------------------ CC1G_14302_Ccin ------------------------------------------------------------ CC1G_08873_Ccin ------------------------------------------------------------ CC1G_12594_Ccin ------------------------------------------------------------ CC1G_11146_Ccin ------------------------------------------------------------ CC1G_00657_Ccin ------------------------------------------------------------ CC1G_02529_Ccin ------------------------------------------------------------ CC1G_10953_Ccin ------------------------------------------------------------ CC1G_07428_Ccin ------------------------------------------------------------ ak1_Ddis -----------------------NGMLNFSNLNIGG--------STSSACSTNSSSNITI 10338_Tthe ------------------------------------------------------------ AlphaK2_Hsap SNSGGLDETQLLSSENNPLVQFKEGGDKSPSPSAADTTATPASYSSIVSFPWEKP----- AlphaK3_Hsap ------------------------------------------------------------ AlphaK1_Hsap --------------------------------------------GSQTSSAWSNL----- AlphaK1_Mmus --------------------------------------------DNSSSCSWGRL----- AlphaK2_Mmus YSERGFGETQPLCSETISFVKDSEGSYRSSSLSIPAAIDTLASYSSDRECSKEQS----- AlphaK3_Mmus ------------------------------------------------------------ CC1G_14582_Ccin ------------------------------------------------------------ CC1G_06337_Ccin ------------------------------------------------------------ CC1G_14302_Ccin --------------------------------------------------THNRL----- CC1G_08873_Ccin ------------------------------------------------------------ CC1G_12594_Ccin ------------------------------------------------------------ CC1G_11146_Ccin ------------------------------------------------------------ CC1G_00657_Ccin ------------------------------------------------------------ CC1G_02529_Ccin ------------------------------------------------------------ CC1G_10953_Ccin ------------------------------------------------------------ CC1G_07428_Ccin ------------------------------------------------------------ ak1_Ddis ANNINSSNNINIINNQNNQNNNNNNNTNNVMISPSPSPNPF------------------- 10338_Tthe ------------------------------------------------------------ AlphaK2_Hsap ------------------------------TTLTAN-----NECFQATRETEDTSTVTIA AlphaK3_Hsap ------------------------------------------------------------ AlphaK1_Hsap ------------------------------SGFS-----SSASWEEVNYHVDDRSARKEP AlphaK1_Mmus ------------------------------SGLS-----SSTSWEEVNCAVQDVVRKGSG AlphaK2_Mmus ------------------------------AESTAN-----VDCHQVTREMEGIST--NA AlphaK3_Mmus ------------------------------------------------------------ CC1G_14582_Ccin ------------------------------------------------------------ CC1G_06337_Ccin ------------------------------------------------------------ CC1G_14302_Ccin ------------------------------LKLSPDTERNEPSWEEVTVHLQEGTNKAV- CC1G_08873_Ccin ------------------------------------------------------------ CC1G_12594_Ccin ------------------------------------------------------------ CC1G_11146_Ccin ------------------------------------------------------------ CC1G_00657_Ccin ------------------------------------------------------------ CC1G_02529_Ccin ------------------------------------------------------------ CC1G_10953_Ccin ------------------------------------------------------------ CC1G_07428_Ccin -----------------------------------------------------------G ak1_Ddis ------------------------------------------------------------ 10338_Tthe ------------------------------------------------------------ AlphaK2_Hsap TEVHPAKYLAVSIPEDKHAGGT-EERFPRASHEKVS-QFPS-QV-QLDHILSGATIKSTK AlphaK3_Hsap --------------------------PVEAKQEDSPFQCPKEERPGGVPCMDQGGCPLAG AlphaK1_Hsap GKEHLV----------------------DTQCSTALSEELENDRE--------------- AlphaK1_Mmus QEEHPV----------------------EAQSSEAASEEPKRNRS--------------- AlphaK2_Mmus AEVHEIKCHSVSVPQDNDFDVGADQVSCEARDEDNSQSLPDDDS-QSGRSLSSSTGEATG AlphaK3_Mmus --------------------------HQRSEQEDSLSQCPKKEQPQEPLHVGLSGGHSTG CC1G_14582_Ccin ------------------------------------------------------------ CC1G_06337_Ccin ------------------------------------------------------------ CC1G_14302_Ccin ------------------------------------------------------------ CC1G_08873_Ccin --PRPVKRLNLKIVKLFDFRQG-KYLPGAPFHADNT-EYPD-DT-PMATVLE-------- CC1G_12594_Ccin --PRPVKRLNLKIVKLFDFRQG-KYLPGAPFHADNT-EYPD-DT-PMATVLE-------- CC1G_11146_Ccin ------------------------------------------------------------ CC1G_00657_Ccin ------------------------------------------------------------ CC1G_02529_Ccin ------------------------------------------------------------ CC1G_10953_Ccin ------------------------------------------------------------ CC1G_07428_Ccin VVSKPVKLLNISIQKMTDYDGG-KYRSGPVFHAWQR-RYPE-DT-PMDEVFN-------- ak1_Ddis ----LP-TPTSTNQNNH-IITPIPVNPFTD-NLQLNSNNIRQHPQ-QMYIQQQQQQQQQQ 10338_Tthe ------------------------------------------------------------ AlphaK2_Hsap EL-LCR-APSVPGVPHHVLQLPEGEGFCSNSPLQVDNLSGDKS-QTVDRADFRSYEENFQ AlphaK3_Hsap LSQEVP-TMPSLPGT--GLTASPKAGPCSTP----------------------------- AlphaK1_Hsap -GRAMHSLHSQLHDL--SLQEPNNDNLEPSQ----------------------------- AlphaK1_Mmus -SRAVY-LSSKLRGV--SLQTTGDDNLESSP----------------------------- AlphaK2_Mmus ET-LVP-APSSAGDHGH-FSMPEGQGLCSR-ALQMDNQPVCQS-QAMEGAHSRGLEEHFQ AlphaK3_Mmus LSQEVP-AMPSLPGT--GLTSSLQEELPGTA----------------------------- CC1G_14582_Ccin ------------------------------------------------------------ CC1G_06337_Ccin ------------------------------------------------------------ CC1G_14302_Ccin --------------------------------------------------SIDHFD---- CC1G_08873_Ccin ------------------------------------------------------------ CC1G_12594_Ccin ------------------------------------------------------------ CC1G_11146_Ccin ------------------------------------------------------------ CC1G_00657_Ccin -VKNKH-IPDGWM-------SATL------------------------------------ CC1G_02529_Ccin ------------------------------------------------------------ CC1G_10953_Ccin ------------------------------------------------------------ CC1G_07428_Ccin ------------------------------------------------------------ ak1_Ddis QQQQQQQQQQQQQQQQQQL-QMQQQ---QQQQMQQHYQQQ-QQQQQQQQQQQQQQQQQQQ 10338_Tthe ------------------------------------------------------------ AlphaK2_Hsap ERGSETKQGVQQQSLSQQG-SLSAP---DFQQSLPTTSAA-QEERN-------------- AlphaK3_Hsap -------TSQ---HGSTAT-FLPSE---D-QVLMSSAPTL-HLGLG-------------- AlphaK1_Hsap -------NQP---QQQMPLTPFSPHNTPG-IFLA-------------------------- AlphaK1_Mmus -------SQL---HNHTSILPFNAK---D-TCLA-------------------------- AlphaK2_Mmus EKGSGMKHGIRPQSTSHQV-SLSAN---DFQEILPSIPTM-QQETN-------------- AlphaK3_Mmus -------ASL---HTNTDV-PLPSR---D-QDFPSSAPTL-QLGPG-------------- CC1G_14582_Ccin ------------------------------------------------------------ CC1G_06337_Ccin ------------------------------------------------------------ CC1G_14302_Ccin ----------------------------KNDSILALFNYL-VQENF-------------- CC1G_08873_Ccin -----------------------------------DIRTKVDNA---------------- CC1G_12594_Ccin -----------------------------------DIRTKVDNA---------------- CC1G_11146_Ccin ------------------------------------------------------------ CC1G_00657_Ccin ------------------------------------------------------------ CC1G_02529_Ccin ------------------------------------------------------------ CC1G_10953_Ccin ------------------------------------------------------------ CC1G_07428_Ccin -----------------------------------DVFHLVVNTY--------------- ak1_Ddis QQQQQQQQQQQQQQQQQQQQQ--------------------------------------- 10338_Tthe ------------------------------------------------------------ AlphaK2_Hsap --------------------LVPTAH---SPASSREGAGQRSGWGTRVSVVAETAGEEDS AlphaK3_Hsap --------------------TPTQSHPPETMATSSE-GACAQVPDVEG------------ AlphaK1_Hsap ------------------------------------------------------------ AlphaK1_Mmus ------------------------------------------------------------ AlphaK2_Mmus --------------------VEPLEH---SLADSREEIECSSDPRTSDLVVAEKTVGEDS AlphaK3_Mmus --------------------SPTQSHPPEAMATSSE-GACAKEPNVDG------------ CC1G_14582_Ccin ------------------------------------------------------------ CC1G_06337_Ccin ------------------------------------------------------------ CC1G_14302_Ccin --------------------LKPSQ-----VADRHIEIWFAFD----------------- CC1G_08873_Ccin ------------------------------------------------------------ CC1G_12594_Ccin ------------------------------------------------------------ CC1G_11146_Ccin ------------------------------------------------------------ CC1G_00657_Ccin ------------------------------------------------------------ CC1G_02529_Ccin ------------------------------------------------------------ CC1G_10953_Ccin ------------------------------------------------------------ CC1G_07428_Ccin ------------------------------------------------------------ ak1_Ddis ------------------------------------------------------------ 10338_Tthe -----------------------------------------QLIWQQATVYA-------- AlphaK2_Hsap QALSNVPSLSDILLEESKEYRPGNWEAGNKLKIITLEASASEIWPPRQLTNSESKASDGG AlphaK3_Hsap -------------------------------------------------RTPGPRSCDPG AlphaK1_Hsap ------------------------------------------------------------ AlphaK1_Mmus ------------------------------------------------------------ AlphaK2_Mmus HLVVSVPALPDILLGEKDDVGLGSWAVGGKVKIITLEAPVFEIWPPELVRHPGYKEAEAG AlphaK3_Mmus -------------------------------------------------RSSGTRSCDPG CC1G_14582_Ccin ------------------------------------------------------------ CC1G_06337_Ccin ------------------------------------------------------------ CC1G_14302_Ccin -----------------------------------------------EKSDYISGVSEG- CC1G_08873_Ccin -------------YKKDRDYRVY-------------DINEFTMLWASARVAVDPSLCTG- CC1G_12594_Ccin -------------YKKDRDYRVY-------------DINEFTMLWASARVAVDPSLCTG- CC1G_11146_Ccin ------------------------------------------------------------ CC1G_00657_Ccin ------------------------------------------------------------ CC1G_02529_Ccin ------------------------------------------------------------ CC1G_10953_Ccin ------------------------------------------------------------ CC1G_07428_Ccin -------------IAKPREYRIY-------------DMSEYQILWHRSKTTVESEMCKG- ak1_Ddis ------------------------------------------------------------ 10338_Tthe ------------------------------------------------------------ AlphaK2_Hsap LIIPDKVWAVP------------------------------------------------- AlphaK3_Hsap LIDSLKNYLLLLLKLSSTETSGAGGESQVGAATGGLVPSATLTPTVEVAGLSPRTSRRIL AlphaK1_Hsap ------------------------------------------------------------ AlphaK1_Mmus ------------------------------------------------------------ AlphaK2_Mmus LTMPGRSWALS------------------------------------------------- AlphaK3_Mmus LIDSLKNYLLLLLKLSSPETSEARAESQEVADTGGLTSSSTLVPTMEVAGLSPRTSRRIL CC1G_14582_Ccin ------------------------------------------------------------ CC1G_06337_Ccin ------------------------------------------------------------ CC1G_14302_Ccin ------------------------------------------------------------ CC1G_08873_Ccin ------------------------------------------------------------ CC1G_12594_Ccin ------------------------------------------------------------ CC1G_11146_Ccin ------------------------------------------------------------ CC1G_00657_Ccin ------------------------------------------------------------ CC1G_02529_Ccin ------------------------------------------------------------ CC1G_10953_Ccin ------------------------------------------------------------ CC1G_07428_Ccin ------------------------------------------------------------ ak1_Ddis ------------------------------------------------------------ 10338_Tthe ------------------------------------------------------------ AlphaK2_Hsap DSLKADAVVPELAPSEIAALAHSPE-DAESALADSRESHKGEEPTISVHWRSLSSRGFSQ AlphaK3_Hsap ERV-------------------------------------------ENNHLVQSAQTLL- AlphaK1_Hsap ------------------------------------------------------------ AlphaK1_Mmus ------------------------------------------------------------ AlphaK2_Mmus DILRAGATRSEPGALGGAAWVPSPQADALMALGANRDTWLGAAPDRQANCNCLSSQCLSQ AlphaK3_Mmus ERV-------------------------------------------ENNHLVQSAQTLL- CC1G_14582_Ccin ------------------------------------------------------------ CC1G_06337_Ccin ------------------------------------------------------------ CC1G_14302_Ccin --------------------------------------------LQSAIPLRQSTAKSA- CC1G_08873_Ccin --------------------------------------------TLRDLWRACSANSLL- CC1G_12594_Ccin --------------------------------------------TLRDLWRACSANSLL- CC1G_11146_Ccin ------------------------------------------------------------ CC1G_00657_Ccin ----------------------------------------------EAYKGFCASQNWL- CC1G_02529_Ccin ------------------------------------------------------------ CC1G_10953_Ccin ------------------------------------------------------------ CC1G_07428_Ccin --------------------------------------------TVGDLWHAVSTNSFL- ak1_Ddis --------------------------------------------------QHINLSSSA- 10338_Tthe -----------------RL----------------------------------------- AlphaK2_Hsap PRLLESSVDPVD--EKELSVTDSLSAASETGGKENVNNVSQDQEEKQLKMDH-----TAF AlphaK3_Hsap -------LSPCT--SRR------------------------------------------- AlphaK1_Hsap ------------------------------------------------------------ AlphaK1_Mmus ------------------------------------------------------------ AlphaK2_Mmus PRFLESSVDPVE--DKELEVTDSPSEVSKTGEMEMPETLNEEQEETQQILRH-----PAV AlphaK3_Mmus -------LSPCT--SRR------------------------------------------- CC1G_14582_Ccin ------------------------------------------------------------ CC1G_06337_Ccin ------------------------------------------------------------ CC1G_14302_Ccin -------VPPAQ--SKASA----------------------------------------- CC1G_08873_Ccin -------VSPAD--VKKSL----------------------------------------- CC1G_12594_Ccin -------VSPAD--VKKSL----------------------------------------- CC1G_11146_Ccin ------------------------------------------------------------ CC1G_00657_Ccin -------VPLTGPTARR------------------------------------------- CC1G_02529_Ccin ------------------------------------------------------------ CC1G_10953_Ccin ------------------------------------------------------------ CC1G_07428_Ccin -------VPPGD--YKAAA----------------------------------------- ak1_Ddis PLQSVNHSP------------------IPLQPQ--HSSSQYMNQQGYQVY---------- 10338_Tthe ------------------------------------------------------------ AlphaK2_Hsap FKKFLTCPKILESSVDPIDEISVIEYTRAGKPEPSETTPQGAREGGQSND---------G AlphaK3_Hsap -------------------------------------------------L--------TG AlphaK1_Hsap ------------------------------------------------------------ AlphaK1_Mmus ------------------------------------------------------------ AlphaK2_Mmus VNQSVNFPRILESSVDPIDDRGELEGVWPEKPEPSDSSV----EGNEFIV---------G AlphaK3_Mmus -------------------------------------------------L--------TG CC1G_14582_Ccin ------------------------------------------------------------ CC1G_06337_Ccin ------------------------------------------------------------ CC1G_14302_Ccin ------------------------------------------------------------ CC1G_08873_Ccin ------------------------------------------------------------ CC1G_12594_Ccin ------------------------------------------------------------ CC1G_11146_Ccin -------------------------------------------------------PPVTV CC1G_00657_Ccin -------------------------------------------------ARVGGLPSMGV CC1G_02529_Ccin ------------------------------------------------------------ CC1G_10953_Ccin ------------------------------------------------------------ CC1G_07428_Ccin ------------------------------------------------------------ ak1_Ddis PN-----------------------------------VGNQPQSPQQIQPQPL----QQQ 10338_Tthe -FNKEINIIM------EN--VKAKNCT--------------------------------- AlphaK2_Hsap NMGHEA--EIQPAILQVPCLQ--GTILS-ENRISRSQEGSMKQEAEQIQPEEA----KTA AlphaK3_Hsap LLDREV--QA-------------------------------------------GRQALAA AlphaK1_Hsap ------------------------------------------------------------ AlphaK1_Mmus ------------------------------------------------------------ AlphaK2_Mmus NTCQRV--DIQPASLQLPHPQDSGEIIPYEHTTNQNRVDGERAEAKTSLPDKAKAEAEAV AlphaK3_Mmus LLDREV--QA-------------------------------------------GQQALAA CC1G_14582_Ccin ------------------------------------------------------------ CC1G_06337_Ccin ------------------------------------------------------------ CC1G_14302_Ccin -RVLHSRPSAQQVFSRDPPLVEVTFLRVT------------------------------- CC1G_08873_Ccin -IEWAV--AVNYDEARND--TDDDDTV--------------------------------- CC1G_12594_Ccin -IEWAV--AVNYDEARND--TDDDDTV--------------------------------- CC1G_11146_Ccin NFELFV--LMKMYTKRIE--LSEEDG---------------------------------- CC1G_00657_Ccin PFELFL--KMNMYYARLE--REGSAA---------------------------I------ CC1G_02529_Ccin ------------------------------------------------------------ CC1G_10953_Ccin ------------------------------------------------------------ CC1G_07428_Ccin -MVWHV--DVQYDDSREPHIEDVEDVEPKT------------------------------ ak1_Ddis IFQQVQQQQPQIPQQS-----PQPLQSSTDE---------------DQSVLEVLNL---- 10338_Tthe --------------------------------------------------PEFEL----- AlphaK2_Hsap IWQ----------VLQPSEGGERIPSGCS------------------------------- AlphaK3_Hsap ARG----------SWGPGPSSLTVPAIVVDEEDP-GLASEGASEGEGEVSPEGPGLLGAS AlphaK1_Hsap ------------------------------------------------------------ AlphaK1_Mmus ------------------------------------------------------------ AlphaK2_Mmus VWQ----------AQGPGEEGQGIPSVCS------------------------------- AlphaK3_Mmus AQC----------SRGPCPTPLTIPAIVVGEEGSAGEDSEE----------------RTS CC1G_14582_Ccin ------------------------------------------------------------ CC1G_06337_Ccin ------------------------------------------------------------ CC1G_14302_Ccin ------------------------------------------------------------ CC1G_08873_Ccin --------------------------------------------------PEFQG----- CC1G_12594_Ccin --------------------------------------------------PKFKGK---- CC1G_11146_Ccin ------------------------------------------------------------ CC1G_00657_Ccin --------------------------------------------------LDQIGV---- CC1G_02529_Ccin ------------------------------------------------------------ CC1G_10953_Ccin ------------------------------------------------------------ CC1G_07428_Ccin ------------------------------------------------------------ ak1_Ddis --------------------------------------------------KK-------- 10338_Tthe ------------------------------------------------------------ AlphaK2_Hsap -------------------------------------------------IG--------- AlphaK3_Hsap QESSMAGRLGEAGG-QAAPGQGPSAE----------------------SIAQEPSQEEKF AlphaK1_Hsap ------------------------------------------------------------ AlphaK1_Mmus ------------------------------------------------------------ AlphaK2_Mmus -------------------------------------------------MS--------- AlphaK3_Mmus QESDKKGLLGEV--------EGHTVE----------------------SRTQEPCQEEAM CC1G_14582_Ccin ------------------------------------------------------------ CC1G_06337_Ccin ------------------------------------------------------------ CC1G_14302_Ccin --------------------------------------------------A--------- CC1G_08873_Ccin ------------------------------------------------------------ CC1G_12594_Ccin ---------TKASLFRISY-----TNPNRSLD---------------------------- CC1G_11146_Ccin ---------------RPSG-----KRRDRSEYLVAYSTGHGPSKIARQQ----------- CC1G_00657_Ccin ---------GSSSLVRPSA-----NKRARAG-----------------T----------- CC1G_02529_Ccin ------------------------------------------------------------ CC1G_10953_Ccin ------------------------------------------------------------ CC1G_07428_Ccin ------------------------------------------------------------ ak1_Ddis ---------------LFDMN---------------------------------------- 10338_Tthe ------------------------------------------------------------ AlphaK2_Hsap ------------------------------QIQESSDGSLGEAEQSKKDKAELISPTSPL AlphaK3_Hsap PGEALTGLPAATPEELALGAR---RKRFLPKVRAAGD---GEATTPEERESPTVSPRGPR AlphaK1_Hsap --PG----AGLLEG-APE--GIQEVRNMG------------------------------- AlphaK1_Mmus --SG----AGLVET-A-----------EG------------------------------- AlphaK2_Mmus ------------------------------QTQDGGDRSLGEAGQRGTDETEVISPLSPL AlphaK3_Mmus PGEALTGLPAATPEELALGAR---RKRFLPKVRAGSD---GEANKAEERESPTVSPRGPR CC1G_14582_Ccin ------------------------------------------------------------ CC1G_06337_Ccin ------------------------------------------------------------ CC1G_14302_Ccin ------------------------------STENGADISWSQASTLEKTETILVSKNLEA CC1G_08873_Ccin --VG----AAALQANTSKGASAKRM----------------------------------- CC1G_12594_Ccin --VG----AAALQANTSKGASAKRM----------------------------------- CC1G_11146_Ccin ---------NPIQSSFSL-PPAGTMRT-VPT----------------------------- CC1G_00657_Ccin ------------SS----NVS---LISKIPR---YSC---VPV---------SSFS---- CC1G_02529_Ccin ------------------------------------------------------------ CC1G_10953_Ccin ------------------------------------------------------------ CC1G_07428_Ccin ------------------------------------------------------------ ak1_Ddis -------------------------MMDKEEFEHRRRQIIDNLTKTTSPIHQQP--PQPP 10338_Tthe ------------------------------------------------------------ AlphaK2_Hsap SSCLPIMTHASLGVDTHNSTGQIHDVPENDIVEPRKRQYVFPVSQKRGTIENERGKPLPS AlphaK3_Hsap KSLVPGS----------------------------------------------------- AlphaK1_Hsap ----------------------------------------PRNTSA-------------- AlphaK1_Mmus ----------------------------------------SSNTSL-------------- AlphaK2_Mmus SSCLTGVTHTCVKAETNNSTGHIYGG-----SEPRTRQSVIPMKTEKGTIESKCGNHVRS AlphaK3_Mmus KGLTPGS----------------------------------------------------- CC1G_14582_Ccin ------------------------------------------------------------ CC1G_06337_Ccin ------------------------------------------------------------ CC1G_14302_Ccin NSTNPGF----------------------IG----------------------------- CC1G_08873_Ccin ------------------------------------------------------------ CC1G_12594_Ccin ------------------------------------------------------------ CC1G_11146_Ccin ------------------------------------------------------------ CC1G_00657_Ccin ------------------------------------------------------------ CC1G_02529_Ccin ------------------------------------------------------------ CC1G_10953_Ccin ------------------------------------------------------------ CC1G_07428_Ccin -----------------------------QIVPRSKRANSVASTALRTQIESRSG----- ak1_Ddis QPV---LP---------------------VSAPAQVPQPHPPQQQNGPTVPQQQQQQQQQ 10338_Tthe ------------------------------------------------------------ AlphaK2_Hsap SPDLTRFPCTSSPEGNVTDFLISHKMEEPKIEVLQIGETKPPSSSSSSAKTLAFISGERE AlphaK3_Hsap ------------------------------------------------------------ AlphaK1_Hsap ------------------------------------------------------------ AlphaK1_Mmus ------------------------------------------------------------ AlphaK2_Mmus SDDLTNTPCTSSPKGNVTRLSISHGLEELKSEKLQIAETKPLNSSDSPTMTLALISGECE AlphaK3_Mmus ------------------------------------------------------------ CC1G_14582_Ccin ------------------------------------------------------------ CC1G_06337_Ccin ------------------------------------------------------------ CC1G_14302_Ccin ------------------------------------------------------------ CC1G_08873_Ccin ------------------------------------------------------------ CC1G_12594_Ccin ------------------------------------------------------------ CC1G_11146_Ccin ------------------------------------------------------------ CC1G_00657_Ccin ------------------------------------------------------------ CC1G_02529_Ccin ------------------------------------------------------------ CC1G_10953_Ccin ------------------------------------------------------------ CC1G_07428_Ccin ------------------------------------------------------------ ak1_Ddis Q----------------QQQQQQQQQQQQQQQPIPQPSSSSPTP--DARLTGTERVIRHR 10338_Tthe ------------------------------------------------------------ AlphaK2_Hsap LEKAPK--LLQDPCQKG-TLGCAKKSR-EREKSLEARAGKSPGT--LTAVTGSEEVKRKP AlphaK3_Hsap ------------------PGTPGRERRSPT-----QGRKASM-----------LEVPRAE AlphaK1_Hsap -------------------------------HSRPSYRS--------------------- AlphaK1_Mmus -------------------------------QSSHSCGS--------------------- AlphaK2_Mmus SEKDPKSLLRRDPCPKGSTLDSGKKSRDQQQKPVAAQVSKAPGD--QSAMAGSEEGKKKQ AlphaK3_Mmus ------------------PGTPGRERRSPT-----QARKASM-----------LEVPGAE CC1G_14582_Ccin ------------------------------------------------------------ CC1G_06337_Ccin ------------------------------------------------------------ CC1G_14302_Ccin ------------------------------------------------------------ CC1G_08873_Ccin ------------------------------RTIIPSGRNAYVTRLGVAQSTGIVHIVL-- CC1G_12594_Ccin ------------------------------RTIIPSGRNAYVTRLGVAQSTGIVHIVL-- CC1G_11146_Ccin ------------------------------------STKAKF-----------QQS---- CC1G_00657_Ccin -----------------------------------GAHTSFS-----------TKK---- CC1G_02529_Ccin ------------------------------------------------------------ CC1G_10953_Ccin ------------------------------------------------------------ CC1G_07428_Ccin ----------------------------KKPRLLPAGKDAYVTR--VVNPSGTSYTVI-- ak1_Ddis FD-------AKLGKWV-QT------------A--------TI------------------ 10338_Tthe ------------------------------------------------------------ AlphaK2_Hsap EAPGSGHLAEG--------VKKKILSRVAALR--------LKLEEKENIRKNSAFLKKMP AlphaK3_Hsap EELAAGDLGPS--------PKAG------------------------------------- AlphaK1_Hsap ------------ASWS-SD------------SGRPKNMGTHPSVQKEE------------ AlphaK1_Mmus ------------DSWSLSS------------SDRFTDVTTNPSVQEEE------------ AlphaK2_Mmus EASGSGHLTAG--------IKKKILSRVAALR--------LRLEEKENSRKNS-IVKKTP AlphaK3_Mmus EEPATGDLVSR--------SKDS------------------------------------- CC1G_14582_Ccin ------------------------------------------------------------ CC1G_06337_Ccin ------------------------------------------------------------ CC1G_14302_Ccin ------------------------------------------------------------ CC1G_08873_Ccin ---------KGYWTWV-ED------------S--------AVWVEEQE------------ CC1G_12594_Ccin ---------KGYWTWV-ED------------S--------AVWVEEQE------------ CC1G_11146_Ccin ------------------------------------------------------------ CC1G_00657_Ccin ------------------------------------------------------------ CC1G_02529_Ccin ------------------------------------------------------------ CC1G_10953_Ccin ------------------------------------------------------------ CC1G_07428_Ccin ---------KGAWKFG-KGT-----------S--------VIWVEEEDV----------- ak1_Ddis ----------------------------------VI------------------------ 10338_Tthe ---------------FINQHYRRIVMPQPQI---IQIEK--------------------- AlphaK2_Hsap KLETSLSHTEEKQD--PKKPSCKREGRAPVLLKKIQAEM-------------------FP AlphaK3_Hsap GLDTEVALDEGKQETLAKPRKAKDLLKAPQVIRKIRVEQ-------------------FP AlphaK1_Hsap -------------------------------AFEIIVEFPETNCDVKDRQGKEQGEEISE AlphaK1_Mmus -------------------------------PSGIMGDVPESKYDCKDWHGEKNGGTLAE AlphaK2_Mmus KFERSLSRTDEKRD--PKRAPCKAEGKAPVLLKRIQAEM-------------------AP AlphaK3_Mmus GLDSEPAVDEGKQEALAKQRKAKDLLKAPQVIRKIRVEQ-------------------FP CC1G_14582_Ccin ------------------------------------------------------------ CC1G_06337_Ccin ------------------------------------------------------------ CC1G_14302_Ccin ------------------------------------------------------------ CC1G_08873_Ccin -------------------------------PFKVVVDK-------------------ES CC1G_12594_Ccin -------------------------------PFKVVVDK-------------------ES CC1G_11146_Ccin --------------------------------------C-------------------CV CC1G_00657_Ccin --------------------------------------L-------------------VT CC1G_02529_Ccin ------------------------------------------------------------ CC1G_10953_Ccin ------------------------------------------------------------ CC1G_07428_Ccin -------------------------------KLKVIVEK-------------------TP ak1_Ddis --------------------------------------------------T--------- 10338_Tthe ------------------------------------------------------------ AlphaK2_Hsap EHSG-----------NVK-LSC-Q-FAE---IHEDSTICWTKDSKSIAQV-QRSA-GDNS AlphaK3_Hsap DASG-----------SLK-LWC-Q-FFN---ILSDSVLTWAKDQRPVGEV-GRSA-GDEG AlphaK1_Hsap RGAGPTFKASPSWVDPEG-ETA-ES---TE------------------------------ AlphaK1_Mmus ICTGPELTSAPSSVDPEG-ETA-ES---TD------------------------------ AlphaK2_Mmus EHSG-----------NIK-LSC-Q-FSE---IHEDSTVCWTKDSKSIAQA-KKSA-GDNS AlphaK3_Mmus DSSG-----------SLK-LWC-Q-FFN---IVSDSVLTWAKDQHPVGEV-NRSA-GDEG CC1G_14582_Ccin ------------------------------------------------------------ CC1G_06337_Ccin ------------------------------------------------------------ CC1G_14302_Ccin --KGTSKYAYYGRM--------------------ATSTGWKEYA---------------- CC1G_08873_Ccin FASGVTKKAVKMYIDKKK-YAA-KYFY--------------------------------- CC1G_12594_Ccin FASGVTKKAVKMYIDKKK-YAA-KYFY--------------------------------- CC1G_11146_Ccin QLTP-----------LGD-PVIQN-ERMITGFISD---VHV-AQGSMKVVHEKDAGLRRG CC1G_00657_Ccin RTKV-----------EVQRITC-K-VLN---NQGDPA---FEKKEKLDLYISDAF-FASG CC1G_02529_Ccin ------------------------------------------------------------ CC1G_10953_Ccin ------------------------------------------------------------ CC1G_07428_Ccin FASGVTKKAHKAYIGTEK-IAA-KYFYD---IHDGS------------------------ ak1_Ddis ------------------------------------------------------------ 10338_Tthe ------------------------------------------------------------ AlphaK2_Hsap TVSFAIVQASPKD----QGLYYCC----------------IKNSYGKVT----------- AlphaK3_Hsap PAALAIVQASPVD----CGVYRCT----------------IHNEHGSAS----------- AlphaK1_Hsap -------------DAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQG AlphaK1_Mmus -------------DGLSPSQVALGCLEGSHSMSTRRTFFPDGSVQNADSAKTGCSVRDQT AlphaK2_Mmus SVSLAIVQAGQKD----QGLYYCC----------------LKNSYGKVT----------- AlphaK3_Mmus PAALAIVQASPTD----CGVYRCT----------------IQNEHGSAS----------- CC1G_14582_Ccin ------------------------------------------------------------ CC1G_06337_Ccin ------------------------------------------------------------ CC1G_14302_Ccin ---------------------------------------------VAVL----------- CC1G_08873_Ccin -----------------------D----------------IDG-SGAV------------ CC1G_12594_Ccin -----------------------D----------------IDG-SGAV------------ CC1G_11146_Ccin SSK-------------------------------------------SERAKT-------- CC1G_00657_Ccin TMKVVFDASIPDYDSPLIVKRFFK----------------IDNLSSPELDKSGTP----- CC1G_02529_Ccin ------------------------------------------------------------ CC1G_10953_Ccin ------------------------------------------------------------ CC1G_07428_Ccin ---------------------------------------------SSVL----------- ak1_Ddis ------------------------------------------------------------ 10338_Tthe ------------------------------------------------------------ AlphaK2_Hsap ------------------------------------------------------------ AlphaK3_Hsap ------------------------------------------------------------ AlphaK1_Hsap IDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSE AlphaK1_Mmus VDPDASTVDEEGQMLDSTEICSIGQDGAHRPRALRS--GQSAEGPKSFVNGSSPSPIFDE AlphaK2_Mmus ------------------------------------------------------------ AlphaK3_Mmus ------------------------------------------------------------ CC1G_14582_Ccin ------------------------------------------------------------ CC1G_06337_Ccin ------------------------------------------------------------ CC1G_14302_Ccin ------------------------------------------------------------ CC1G_08873_Ccin ------------------------------------------------------------ CC1G_12594_Ccin ------------------------------------------------------------ CC1G_11146_Ccin ------------------------------------------------------------ CC1G_00657_Ccin ------------------------------------------------------------ CC1G_02529_Ccin ------------------------------------------------------------ CC1G_10953_Ccin ------------------------------------------------------------ CC1G_07428_Ccin ------------------------------------------------------------ ak1_Ddis ------------------------------------------------------------ 10338_Tthe ------------------------------------------------------------ AlphaK2_Hsap -------------------------------------------------------AEFN- AlphaK3_Hsap -------------------------------------------------------TDFC- AlphaK1_Hsap DCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVS--- AlphaK1_Mmus DFSTTEEGEELGSMLKSSQNSSSYSPWWLKSPAFSRSSSDGESSWSLLNSSRSSFAS--- AlphaK2_Mmus -------------------------------------------------------AEFN- AlphaK3_Mmus -------------------------------------------------------TDFC- CC1G_14582_Ccin ------------------------------------------------------------ CC1G_06337_Ccin ------------------------------------------------------------ CC1G_14302_Ccin -------------------------------------------------------QDQQL CC1G_08873_Ccin ------------------------------------------------------------ CC1G_12594_Ccin ------------------------------------------------------------ CC1G_11146_Ccin -------------------------------------------N------------WKA- CC1G_00657_Ccin ----------------------------------------PKAE-----------FDVL- CC1G_02529_Ccin ------------------------------------------------------------ CC1G_10953_Ccin ------------------------------------------------------------ CC1G_07428_Ccin -------------------------------------------------------PEEN- ak1_Ddis ------------------------------------------------E----------- 10338_Tthe ------------------------------------------------------------ AlphaK2_Hsap LTAEVLKQLSSRQDTKGCEEIEFSQLIFKEDFLHDSYFGGRLRGQIATE----------- AlphaK3_Hsap LSPEVLSGFISREEGEVGEEIEMTPMVFAKGLADSGCWGDKLFGRLVSE----------- AlphaK1_Hsap --------LPGKMRKEILEARTLQPDDFEKLLA--GVRHDWLFQRLENTGVFKPSQLHRA AlphaK1_Mmus --------LAGQTSQEILEARTLQPDDLEKLLA--GVRHDWLLQRLENTGVLKSNQLQQA AlphaK2_Mmus LTAEVLKQLSSHTEYRGCEEIEFSQLIFKEDVFNDSYFGDHLRGQISTE----------- AlphaK3_Mmus LSPEVLSGFISREEGEVGEEIEMTPMVFAKGLADSGCWGDKLFGRLVSE----------- CC1G_14582_Ccin ------------------------------------------------------------ CC1G_06337_Ccin ------------------------------------------------------------ CC1G_14302_Ccin SP---------------------------------------------------------- CC1G_08873_Ccin ------------------------------------------------------------ CC1G_12594_Ccin ------------------------------------------------------------ CC1G_11146_Ccin VRN--------------------------------------------LS----------- CC1G_00657_Ccin THNSLIR----------------------------------------AE----------- CC1G_02529_Ccin ------------------------------------------------------------ CC1G_10953_Ccin ------------------------------------------------------------ CC1G_07428_Ccin LR---------------------------------------------------------- ak1_Ddis ---------------------------PTPFAEG--AMRKAFRMKDLSA----------- 10338_Tthe ------------------------------------------------------------ AlphaK2_Hsap ---------------------------ELHFGEG--VHRKAFRSTVMHGLMPVFKPGHAC AlphaK3_Hsap ---------------------------ELRGGGYGCGLRKASQAKVIYGLEPIFESGRTC AlphaK1_Hsap HSALLLKYSKKSELWTAQETIVYLGDYLTVKKKG--RQRNAFWVHHLHQ----------- AlphaK1_Mmus HSALLLKYSKKSELWTAQETVVYLGDYLKVKKKG--KQRNAFWVHYLHQ----------- AlphaK2_Mmus ---------------------------ELHFGEG--VHRKAFRSKVMQGLMPVFQPGHAC AlphaK3_Mmus ---------------------------ELRGGGH--GLQKASRAKVIYGLEPIFESGRTC CC1G_14582_Ccin ------------------------------------------------------------ CC1G_06337_Ccin ------------------------------------------------------------ CC1G_14302_Ccin ------------------------------------------------------------ CC1G_08873_Ccin ------------------------------------------------------------ CC1G_12594_Ccin ------------------------------------------------------------ CC1G_11146_Ccin ---------------------------LARG-------KA--------MLELFYERCE-- CC1G_00657_Ccin ---------------------------GVRAG----LGQR--------LLNSFYRDAE-- CC1G_02529_Ccin ------------------------------------------------------------ CC1G_10953_Ccin ------------------------------------------------------------ CC1G_07428_Ccin ------------------------------------------------------------ ak1_Ddis ---------EGPS--SQMVAKLFKDSNEDRMVYFKDV--EMQTYSKEIAERFNL-K---S 10338_Tthe ---------KSLL--ASLLGKHYKE----------------------------------- AlphaK2_Hsap VLKVHNAIAYGTRNNDELIQRNYK-------LAAQEC--YVQNTARYYAKIYAA-E---A AlphaK3_Hsap IIKVSSLLVFGPSSETSLVGRNYD-------VTIQGC--KIQNMSREYCKIFAA-E---A AlphaK1_Hsap ---------EEIL--GRYVGKDYKEQKG-LWHHFTDV--ERQMTAQHYVTEFNKRLYEQN AlphaK1_Mmus ---------EETL--GRYVGKEYKERKG-LRHHFTDV--ERQMTAQHYVTEFNKRLYEQK AlphaK2_Mmus VLKVHNAVAHGTRNNDELVQRNYK-------LAAQEC--YVQNTARYYAKIYAA-E---A AlphaK3_Mmus IIKVSSLLVFGPSSETSLLGRNYD-------VTIQGC--KIQNMSREYCKIFAA-E---A CC1G_14582_Ccin ------------------------------------------------------------ CC1G_06337_Ccin ------------------------------------------------------------ CC1G_14302_Ccin ------------HNARLLL--------------------RAEYVLMCKGQYFKQ-AFDQL CC1G_08873_Ccin -------------------------SHKDNLVHLKDELLRGHILEVAAEKFVKS-ARHAK CC1G_12594_Ccin -------------------------SHKDNLVHLKDELLRGHILEVAAEKFVKS-ARHAK CC1G_11146_Ccin EKGVDAYLYLSFAKGLLLQE---------------------------------------- CC1G_00657_Ccin QADVNVYKYFFFEIPTFYQE---------------------------------------- CC1G_02529_Ccin ------------------------------------------------------------ CC1G_10953_Ccin ------------------------------------------------------------ CC1G_07428_Ccin ------------CLKDELL--------------------RLQMLGRSIVKFLSI-SKQER ak1_Ddis ---------PPKKIDFVPA-FVMELVE--R-------Q-----GKPFCAVEYF------I 10338_Tthe --------------------------------------G------DLISLESY------L AlphaK2_Hsap QPLEGFGEV--------PEIIPIFLIHRPE-------N-----NIPYATVEEE------L AlphaK3_Hsap RAAPGFGEV--------PEIIPLYLIYRPA-------N-----NIPYATLEEDLGKPL-E AlphaK1_Hsap IPTQIF---------YIPS-TILLILED-K-------T-----IKGCISVEPY------I AlphaK1_Mmus IPTQIF---------YIPS-TILLILED-R-------T-----IKGCISVEPY------I AlphaK2_Mmus QPLEGFGEV--------PEIIPIFLIHRPE-------N-----NIPYATVEEE------L AlphaK3_Mmus RAASGFGEV--------PEIIPLYLIYRPA-------N-----NIPYATLEEDLGKPL-Q CC1G_14582_Ccin ------------------------------------------------------------ CC1G_06337_Ccin ------------------------------------------------------------ CC1G_14302_Ccin AQDLNV-KIPNFCFDF-KEAIFGSLIPKPD-------TQAHLPHHWFLATPLLRCGP--F CC1G_08873_Ccin ISTYDI-RGPAE-------SFILTVVEGPS-------K-----GRAWLVDPL------FE CC1G_12594_Ccin ISTYDI-RGPAE-------SFILTVVEGPS-------K-----GRAWLVDPL------FE CC1G_11146_Ccin IGKHSPASG--------QLCD----SET--DHDGQEVI-----GIKW------LAEERHL CC1G_00657_Ccin ISKPSPASG--------VVSDELF--GVPSESEVE-EN-----LILW------CGERKHP CC1G_02529_Ccin ------------------------------------------------------------ CC1G_10953_Ccin ------------------------------------------------------------ CC1G_07428_Ccin VSVYNL-RV--------PESYVLRTVE--G-------E-----DHAWLADPLF------E ak1_Ddis EGKYEKHNNN-----F-GYKNDYDRNTPQAFSHFSYEDSGCQLIVVDIQGVGD------- 10338_Tthe EGEYRKFNSNS-------GWSDESYPLMQAFSHFTFYNSGGQEILCDLQGIDEID----- AlphaK2_Hsap IGEFVKYSIRDGKEINFLRRESEAGQKCCTFQHWVYQKTSGCLLVTDMQGVGM------- AlphaK3_Hsap SYCSREWGCAE---APTASGSSEAMQKCQTFQHWLYQWTNGSFLVTDLAGVDW------- AlphaK1_Hsap LGEFVKLSNNT---KV-VKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTG------ AlphaK1_Mmus LGEFVKLSNNT---KA-VKNEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTG------ AlphaK2_Mmus IGEFVKYSIRDGKEINFLRRDSEAGQKCCTFQHWVYQKTSGCLLVTDMQGVGM------- AlphaK3_Mmus TYCSRQWGCAG---APAAASSSEALQKCQTFQHWLYQWTNGSFLVTDLTGADW------- CC1G_14582_Ccin ------------------------------------------------------------ CC1G_06337_Ccin ------------------------------------------------------------ CC1G_14302_Ccin DPPFRKFTGND---EMGP-PEDAITAAVHAFAHFSYVYSGGDLVFCDLQGGRDSS----- CC1G_08873_Ccin NAVMRKFSGTD---LA-GANSDLAGRTCDAFAHFSLDDSDGSVVFVDIQGIDSSTLPITS CC1G_12594_Ccin NAVMRKFSGTD---LA-GANSDLAGRTCDAFAHFSLDDSDGSVVFVDIQGIDSSTLPITS CC1G_11146_Ccin SRRIVRFCGTM---QHQTTRTDLAYQTVHTFNHFVYLHTNRQLIFADLQGTPTSVK-LAS CC1G_00657_Ccin SEVVIRFNGTL---SHPSTRTDMKHLTMYAFCHYVYGVTKGTLVFADIQGTPATLT-QG- CC1G_02529_Ccin ------------------------------------------------------------ CC1G_10953_Ccin ------------------------------------------------------------ CC1G_07428_Ccin GAEVQKFSGTS---QAGSNSESLVGQTCDALAHFSFHDSEGSIVFVDIQGFDSASLPMSS ak1_Ddis ----------VYTDPQIHSADGQGF--G-KGNLGI-EGIKRFF-STH----QCNPICHYL 10338_Tthe ------SKTIQLTDPAILSIR-SRF--G-DSDIGY-KKLQYWI-KNH----KCNHICHAL AlphaK2_Hsap ----------KLTDVGIATLA-KGYK-GFKGNCSM-TFIDQFK-ALH----QCNKYCKML AlphaK3_Hsap ----------KMTDVQIATKLRGYQ--G-LKESCFPALLDRFA-SSH----QCNAYCELL AlphaK1_Hsap ----NGKGLIYLTDPQIHSVD-QKV--F-TTNFGK-RGIFYFFNNQH---VECNEICHRL AlphaK1_Mmus ----NGKGLIYLTDPQIHSVD-QKD--V-TTNFGK-RGIFYFFNNQH---ASCNEICHRL AlphaK2_Mmus ----------KLTDVGIATLA-RGYK-GFKGNCSM-TFIDQFR-ALH----QCNKYCKML AlphaK3_Mmus ----------KMTDVQIATKLRGYQ--G-LKESCFPALLDQFA-SSH----QCNTYCDML CC1G_14582_Ccin ---RAAVHALTLFDVVIHSDD-ESY--G-LGGQGT-SGLEELA-ARH----QCNNICKAL CC1G_06337_Ccin ---RAAVHALTLFDVVIHSDD-ESY--G-LGGQGT-SGLEELA-ARH----QCNNICKAL CC1G_14302_Ccin -------GRVCLVDPQCHTLS-KAKDSPVYWDGGP-SKIKIVI-DKHLQDCSQNQYCNAL CC1G_08873_Ccin GIPLNVAHSVTLFDVMIHSSD-GVY--G-LGDQGW-TGIRDFV-TQH----KCNTICAKL CC1G_12594_Ccin GIPLNVAHSVTLFDVMIHSSD-GVY--G-LGDQGW-TGIRDFV-TQH----KCNTICAKL CC1G_11146_Ccin ---GEVVEGMMLFDPMTHTIN-HGS--G-IGDFGQ-EGIDTFV-EQH----TCGPLCRAL CC1G_00657_Ccin ---NQDKDGYLLFDVMTHTEH-KAS--G-IGDFGQ-EGINRFV-EEH----VCQEVCLLL CC1G_02529_Ccin -----------------HTEH-KAS--G-IGDFGE-EGINKFV-EEH----VCQEVCLLL CC1G_10953_Ccin -----------------HTEH-KAS--G-IGDFGE-EGINKFV-EEH----VCQEVCLLL CC1G_07428_Ccin RQGRTAAHALTLFDVMIHSVE-KSY--G-LGDQGT-SGLEDFV-SQH----RCNSICKAL : : * * * ak1_Ddis GLSSVNPKPAND-ES-GTMPR-----PPSIGQSYVRPSAFPPNLQQSFSF----NFPPLK 10338_Tthe KLDDFKLEESLI-YSKSCNNVQQ------------------------------------- AlphaK2_Hsap GLKSLQNNNQKQ-K------------QPSIG----------------------------K AlphaK3_Hsap GLTPLKGPEAAHPQAKAKGSK-----SPSAGRKGSQLS---------PQPQKKGLPSPQG AlphaK1_Hsap SLTRPS------------------------------------------------------ AlphaK1_Mmus SLTRPS------------------------------------------------------ AlphaK2_Mmus GLKSLQNNSQKP-K------------KPIVG----------------KGR----VPT--- AlphaK3_Mmus GLKPLKGPEAAHPQAKAKGSK-----SPSAGRKGSQLS---------PQPQKKGLPSPQG CC1G_14582_Ccin GLPDAKEFCKDL-TVKAGEWEALSVSVPNVD-----LD---------PRR----SPSPVT CC1G_06337_Ccin GLPDAKEFCKDL-TVKAGEWEALSVSVPNVD-----LD---------PRR----SPSPVT CC1G_14302_Ccin GLKFLQYTADDP-FEEPGHQGQDDPASPSRP-----KK---------KRR----TASPRG CC1G_08873_Ccin GLRDVRELWDEY-HADE---------HPALEDK---------------NN----KP---- CC1G_12594_Ccin GLRDVRELWDEY-HADE------------------------------------------- CC1G_11146_Ccin HLLDSDGSDVNAPKA----T---------------------------------------- CC1G_00657_Ccin GFDKQFPLAPVAS--DEQES---------------------------------------- CC1G_02529_Ccin GFDKQFPLTPVTS--YEKYS---------------------------------------- CC1G_10953_Ccin GFDKQFPLAPVTL--YEKYS---------------------------------------- CC1G_07428_Ccin GLTDVTDIWKEV-TAELSDWEAQSMSVPDVD-----LA---------PKR----SPSPVP : ak1_Ddis DHHVLEQLNQQQQHLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQNQQQ 10338_Tthe ------------------------------------------------------------ AlphaK2_Hsap SKV--------------------------------------------------------- AlphaK3_Hsap TRKS-------------------------------------------------------- AlphaK1_Hsap ------------------------------------------------------------ AlphaK1_Mmus ------------------------------------------------------------ AlphaK2_Mmus ------------------------------------------------------------ AlphaK3_Mmus SRKS-------------------------------------------------------- CC1G_14582_Ccin SDNG-------------------------------------------------------- CC1G_06337_Ccin SDNG-------------------------------------------------------- CC1G_14302_Ccin VM---------------------------------------------------------- CC1G_08873_Ccin ------------------------------------------------------------ CC1G_12594_Ccin ------------------------------------------------------------ CC1G_11146_Ccin ------------------------------------------------------------ CC1G_00657_Ccin ------------------------------------------------------------ CC1G_02529_Ccin ------------------------------------------------------------ CC1G_10953_Ccin ------------------------------------------------------------ CC1G_07428_Ccin SDKG-------------------------------------------------------- ak1_Ddis NQQQNQQQQQQQQQQQ-------QQQQNGHPPPQTPLPPTPQQKDKPKIEVFGDILRKLV 10338_Tthe ------------------------------ETWLTN-----------------LYPSKTK AlphaK2_Hsap -----------------------QTNSMTIKKA-GP-----------------ETPGEKK AlphaK3_Hsap -AP-SSKATPQASEPV-------TTQLLGQPPTQEE-----------------GSKAQGM AlphaK1_Hsap -------------------------------------------------------MEKPC AlphaK1_Mmus ------------------------------------------------------LEQTSK AlphaK2_Mmus -------------------------NATQVK-TPES----------------ETPPAERK AlphaK3_Mmus -AP-SSRATLQASQAA-------TVQLLGQPPVQDG-----------------SSKAQSM CC1G_14582_Ccin -----------------------CSALTSLKHYGES-----------------DSSDSEE CC1G_06337_Ccin -----------------------CSALTSLKHYGES-----------------DSSDSEE CC1G_14302_Ccin -----------------------------------------------------AINSLLT CC1G_08873_Ccin ----NADTTYDLDDVDRLEMENDPDADLDQDGVG-D-----------------DRTTAGD CC1G_12594_Ccin -----------------------------------------------------HPALEHK CC1G_11146_Ccin -------------------------------DTEES-----------------EDEAQDN CC1G_00657_Ccin -----------------------ESEEEGS-------------------------DPTNR CC1G_02529_Ccin -----------------------ESEEEGSDPTNRT-----------------SKLASDF CC1G_10953_Ccin -----------------------KSEEEGSDPTNRT-----------------SKLASDF CC1G_07428_Ccin -----------------------HSGLTGLNQYG-------------------ESESSEE ak1_Ddis S 10338_Tthe C AlphaK2_Hsap T AlphaK3_Hsap R AlphaK1_Hsap T AlphaK1_Mmus V AlphaK2_Mmus T AlphaK3_Mmus R CC1G_14582_Ccin D CC1G_06337_Ccin D CC1G_14302_Ccin S CC1G_08873_Ccin N CC1G_12594_Ccin T CC1G_11146_Ccin D CC1G_00657_Ccin T CC1G_02529_Ccin I CC1G_10953_Ccin I CC1G_07428_Ccin D