CLUSTAL W (1.83) multiple sequence alignment CG17698_Dmel MDLTDPLLITKSQQVN-SQEVDFQKKTEDTFPSKFHKNKASCGLLAVNESRCTDHQLQCE CAMKK2_Mmus MSSCVS-SQPTSDR---VAPQDELG---SGGG--SR-----------------EGQKPCE CAMKK1_Mmus MESGPA-VCCQDPR---AELVD-------------------------------------- ckk-1_Cele MYTFQ------------------------------------------------------- CaMKK1_Hsap MEGGPA-VCCQDPR---AELVE-------------------------------------- CaMKK2_Hsap MSSCVS-SQPSSNR---AAPQDELG---GRGS-SSS-----------------ESQKPCE DDB0220010_Ddis MGCIFT-K-PS---PEQQKFDGE--------------------------------DYECE CAMKK_Spur MGVNMVIEKCNRNK---EFEYETIG---ERGE-REKEREREKE-----REKERERERERE AqueK153_Aque MSTMEK-EQAKAPASNTFFIDGHLK---QSGG--KK-----------------DG----E * CG17698_Dmel NNIVGLS-LET----QIAENSSINVSRELKPHDHT---F--------------------- CAMKK2_Mmus ALR-GLSSLSI----HLGM----------------------------------------- CAMKK1_Mmus ----RVAAINV------------------------------------------------- ckk-1_Cele ------------------------------------------------------------ CaMKK1_Hsap ----RVAAIDV------------------------------------------------- CaMKK2_Hsap ALR-GLSSLSI----HLGM----------------------------------------- DDB0220010_Ddis NKK-NLNLISYIRNLLFGNNSHQQLYNEIIP----------------------------- CAMKK_Spur GVR-EMWTLPI----IVAT-ILQTLL-PPEPGRNLLLKAADACMWPAWVPVLKRRRKGPA AqueK153_Aque SKT-ETGSFRT----HV------------------------------------------- CG17698_Dmel -----PKDKQTFKQISDELRKSYENINKVQNIKKSQSVENF--EKCSEINLANKCL-YTN CAMKK2_Mmus --------------------------------------ESF--IVVTECEPGRGVDLNLA CAMKK1_Mmus -------------------------------------------AHLEEADEGPEPA-RNG ckk-1_Cele ------------------------------------------------------------ CaMKK1_Hsap -------------------------------------------THLEEADGGPEPT-RNG CaMKK2_Hsap --------------------------------------ESF--IVVTECEPGCAVDLGLA DDB0220010_Ddis ------TTTS------------------------------------TTSTTTNSVYQNIG CAMKK_Spur YSDQQD-------------EGSCTKMGAGNSATI---CDKFRSSSSSDLSPGSSVDQHPA AqueK153_Aque -------------------------------------------IKV-EDDGQNEVI-RE- CG17698_Dmel LNTSPKERNALD--K--------------------------------------------- CAMKK2_Mmus RDQPPEADG-QELPL--------------------------------------------- CAMKK1_Mmus VDPPPRARAASVIPG--------------------------------------------- ckk-1_Cele ------------------------------------------------------------ CaMKK1_Hsap VDPPPRARAASVIPG--------------------------------------------- CaMKK2_Hsap RDRPLEADG-QEVPL--------------------------------------------- DDB0220010_Ddis LDGY-NNN-NN----------------------------NNNNNNNNNNIMNNYGYDDYG CAMKK_Spur TDKS-NGN-GKKVLSEGQISFGVAPKSFGGKQQHTAGRRENGDGMDTGDASHVALLSDHT AqueK153_Aque TERRL--RE-SHAPS--------------------------------------------- CG17698_Dmel ----------QAMF--I-------------------------------KFHSLELCTDKV CAMKK2_Mmus ------------------------------------EASD---P---------------- CAMKK1_Mmus ------------------------------------SASR---PT--------------- ckk-1_Cele ------------------------------------------------------------ CaMKK1_Hsap ------------------------------------STSR---LL--------------- CaMKK2_Hsap ------------------------------------DTSG---S---------------- DDB0220010_Ddis YSYEEDEDYYDEMPI---------------------PTIV---A---------------- CAMKK_Spur KSTQE-----EDEKMDTMESEPKVIFTAGDADDDDDDLSP---SESTPNFQS-------- AqueK153_Aque ------------------------------------SNSYEQNST--------------- CG17698_Dmel CSLHIHENFCTDIHKCVVDSES----------------------NK---PNKMKK----- CAMKK2_Mmus ----------ESRS-----------------------------------PLSGRKMSLQE CAMKK1_Mmus ----------PVRP-----------------------------------SLSARKFSLQE ckk-1_Cele ------------------------------------------------------------ CaMKK1_Hsap ----------PARP-----------------------------------SLSARKLSLQE CaMKK2_Hsap ----------QARP-----------------------------------HLSGRKLSLQE DDB0220010_Ddis ----------QPQP-------------------------------------------QPQ CAMKK_Spur --WQQHHELVRGRPYLALDTRIRSHSQSEVEDCTYYRGVRPVSSAMPIVDVTGRPLSCGQ AqueK153_Aque ----------STRPSIQI--KVKSD-----------------GDSLVGANSPGKDLSRKE CG17698_Dmel --C-----LD--YESVKRYPCK--------V------------SNEPPQHNTASKPQ-IL CAMKK2_Mmus P----------------------------------------------SQGGPASSSNSLD CAMKK1_Mmus R----------------------------------------------PAGSCLGA----- ckk-1_Cele ------------------------------------------------------------ CaMKK1_Hsap R----------------------------------------------PAGSYLEA----- CaMKK2_Hsap R----------------------------------------------SQGGLAAGG-SLD DDB0220010_Ddis PQP------QPQPQPQQPI-RI--------VSQ----------NQQIPTTPPQQISQ-FN CAMKK_Spur REM-----MPTSPRGRIVV-KS--------ISADNPTQILTSQMLSVPNGSPSSAPKQV- AqueK153_Aque ETMLALSSLTPPPEHRRS--HSFTVDHFKGIGNNNNNK-----V---------------- CG17698_Dmel YETRPIYPNVPYSPYST----PFS-SPRSSRRKPAFRESRRISIDKSGSFLQLNQYRL-- CAMKK2_Mmus MNGRCICPSLSYSPASS----PQS-SPRMPRR-PT-VESHHVSITGLQDCVQLNQYTL-- CAMKK1_Mmus -------QVGPYSTGPA----SHI-SPRSWRR-PT-IESHRVAISDTEDCVQLNQYKL-- ckk-1_Cele ----------------------------------------SVSQQRSESYIQLNQYRL-- CaMKK1_Hsap -------QAGPYATGPA----SHI-SPRAWRR-PT-IESHHVAISDAEDCVQLNQYKL-- CaMKK2_Hsap MNGRCICPSLPYSPVSS----PQS-SPRLPRR-PT-VESHHVSITGMQDCVQLNQYTL-- DDB0220010_Ddis ITG-------------NKSPSSIGSRHRSKPK-ET-LRAHKKR--HKDGHKMVNEYVF-- CAMKK_Spur PASRRIYPSLPYSPYGSPSGSPCA-SPRTKRP-PT-KESRTISILDKLNYVQLNQYHLKD AqueK153_Aque -----------KEPQQQNLLS-PQ-RPKIKRR-ET-VDTPTITREEHEDYSMVNQYKV-- . :*:* . CG17698_Dmel --------------------------------MEQIGQGSYGLVKLAYSEEDSTHYAMKI CAMKK2_Mmus --------------------------------KDEIGKGSYGVVKLAYNENDNTYYAMKV CAMKK1_Mmus --------------------------------QSEIGKGAYGVVRLAYNESEDRHYAMKV ckk-1_Cele --------------------------------MEEIGQGSYGIVKLAYNEEDKNLYALKV CaMKK1_Hsap --------------------------------QSEIGKGAYGVVRLAYNESEDRHYAMKV CaMKK2_Hsap --------------------------------KDEIGKGSYGVVKLAYNENDNTYYAMKV DDB0220010_Ddis --------------------------------VRKLGKGTFGKVKLAYHHDTHHLYAIKI CAMKK_Spur EIGKGSYGVVKLAYSEEDDTNYNYVQLNQYHLKDEIGKGSYGVVKLAYSEEDDTNYAMKI AqueK153_Aque --------------------------------VDIIGHxxxxxxxxxxxxxxxxxxxxxx :*: CG17698_Dmel LSKKRLLRQAGLMRRGPRKA-----------TSPLDRVYREIAVLKKLDHPNVVKLVEVL CAMKK2_Mmus LSKKKLIRQAGFPRRPPPRGARPAPGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVL CAMKK1_Mmus LSKKKLLKQYGFPRRPPPRGSQATQGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVL ckk-1_Cele LDKMKLLKNFACFRQPPPRRNKENA-APSVLRNPLQLVQKEIAILKKLSHPNVVKLVEVL CaMKK1_Hsap LSKKKLLKQYGFPRRPPPRGSQAAQGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVL CaMKK2_Hsap LSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVL DDB0220010_Ddis FNKIRLKKQTMGIGRP----------------NAFDDVLKEIAIMKKMNHINVVKLYEVI CAMKK_Spur LSKKKLIKKGGFAKRPPPRGGKPNK----APKTPLDRVYQEIAILKKLDHPNIVKLFEVL AqueK153_Aque xxxx-------------------------------------------------------- CG17698_Dmel DDPLEDSLYMVFELVKQGEVLR-IPTDNPLSEKRAWSIFRESLLGLEYLHHQKIIHADIK CAMKK2_Mmus DDPNEDHLYMVFELVNQGPVME-VPTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIK CAMKK1_Mmus DDPAEDNLYLVFDLLRKGPVME-VPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIK ckk-1_Cele DDPNDNYLYMVFEFVEKGSILE-IPTDKPLDEDTAWSYFRDTLCGLEYLHYQKIVHRDIK CaMKK1_Hsap DDPAEDNLYLVFDLLRKGPVME-VPCDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIK CaMKK2_Hsap DDPNEDHLYMVFELVNQGPVME-VPTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIK DDB0220010_Ddis NDPQEEYIYIVMEYIEGGSIMS----ANETSEDLARKYFRDIVFGLEYLHEQKVIHKDLK CAMKK_Spur DDPNTDYLYMVFELVEKGPVME-VPSDNPLSEMLAWTYFRDIVQGIEFLHYQKVIHRDIK AqueK153_Aque xxxxxxxxxxxxxxVDTRPVMEDIDVDNAVSEDKAREYFIDLILGLEYVHSCKVVHRDIK : :: : * * : : : *:*::* *::* *:* CG17698_Dmel PGNLLLTEFGHVKIADLGVCNEFL--GDDATISNGSTAGTPAFRAPETLIPGQN-EYCGR CAMKK2_Mmus PSNLLVGEDGHIKIADFGVSNEFK--GSDALLS--NTVGTPAFMAPESLSETRK-IFSGK CAMKK1_Mmus PSNLLLGDDGHVKIADFGVSNQFE--GNDAQLS--STAGTPAFMAPEAISDSGQ-SFSGK ckk-1_Cele PSNLLLSDIGQVKIADFGVSCEFE--GIDAFLS--GTAGTPAFMAPEALTEGANHFYSGR CaMKK1_Hsap PSNLLLGDDGHVKIADFGVSNQFE--GNDAQLS--STAGTPAFMAPEAISDSGQ-SFSGK CaMKK2_Hsap PSNLLVGEDGHIKIADFGVSNEFK--GSDALLS--NTVGTPAFMAPESLSETRK-IFSGK DDB0220010_Ddis PENLLVNSEGVVKITDFGVSHIFD--DDDV-VR--CSRGSPAFLAPELCRNESQ-PISGK CAMKK_Spur PSNLLLDDDNHVKIADFGVSDKFE--GIDALLS--DTVGTPAFMAPESLLEESN-KYGGR AqueK153_Aque PENLLLDDYDRIKIADFGVSENWSSEKQDADLR--SSAGTPAFTAPETLDGVRS-VFGGR * ***: . . :**:*:**. : *. : : *:*** *** . *: CG17698_Dmel AADVWALGATLYSLIFGNVPFLAD--SVPLLYEKIKQDSVKFPENHKVTENLKSCIVQML CAMKK2_Mmus ALDVWAMGVTLYCFVFGQCPFMDE--RIMCLHSKIKSQALEFPDQPDIAEDLKDLITRML CAMKK1_Mmus ALDVWATGVTLYCFVYGKCPFIDD--YILTLHRKIKNEAVVFPEEPEVSEDLKDLILRML ckk-1_Cele AQDIWSLGITLYAFVIGTVPFVDN--YIIALHKKIKNDPIVFPEAPILSEALQDIILGML CaMKK1_Hsap ALDVWATGVTLYCFVYGKCPFIDD--FILALHRKIKNEPVVFPEEPEISEELKDLILKML CaMKK2_Hsap ALDVWAMGVTLYCFVFGQCPFMDE--RIMCLHSKIKSQALEFPDQPDIAEDLKDLITRML DDB0220010_Ddis GVDVWALGVSLYCLIFARTPFISKTNSLLDIYDQIVNHEPTYPR--EISNDLMDLFKRLL CAMKK_Spur ALDVWAMGCTLYCFLFGQVPFQDN--FILGLHNKIRTQPVMFPEDIEVSAEVKHLISRTL AqueK153_Aque ALDVWAAGVTLYCLVYGRVPFVGR--SIPELHEKIISQEIKFPDDITVSEELKDLLIRLL . *:*: * :**.:: . ** : :: :* . :* :: : : * CG17698_Dmel EKNPTQRITIPQLKTSKWVTSDGDYPLPTEEENCCL--VQVDDEDIDSVVRSIP----KL CAMKK2_Mmus DKNPESRIVVPEIKLHPWVTRHGAEPLPSEDENCTL--VEVTEEEVENSVKHIP----SL CAMKK1_Mmus DKNPETRIGVSDIKLHPWVTKHGEEPLPSEEEHCSV--VEVTEEEVKNSVRLIP----SW ckk-1_Cele KKDPGHRLMLHEVKVHTWVTRDGTVPMSSEQENCHL--VTVTEEEIENCVRVIP----RL CaMKK1_Hsap DKNPETRIGVPDIKLHPWVTKNGEEPLPSEEEHCSV--VEVTEEEVKNSVRLIP----SW CaMKK2_Hsap DKNPESRIVVPEIKLHPWVTRHGAEPLPSEDENCTL--VEVTEEEVENSVKHIP----SL DDB0220010_Ddis DKNPLTRIQIAEIKSHKWTTISGTWPMN-ELDH-LI--LSVTDQEMIDAISTDHTIKPSD CAMKK_Spur EKEPQKRITLPELKEDPWITQHGEEPLMSQEENCVL--VEVSQDEVDSCIKRLP----KI AqueK153_Aque NKEPSGRITIPEIRKHKWFLNT-TRYIPSPNENCAGSDLDPTEEDIADAVQEFQ---TPI .*:* *: : ::: * : :: : :::: . : CG17698_Dmel DTLILIK-TMLKKHSFGNPFVKGCSGTSSSLAGCSRIERFIRAGRSNSAPGSYHMST--- CAMKK2_Mmus ATVILVK-TMIRKRSFGNPFEG-S----------------RREERSLSAPGNLLTKKPTR CAMKK1_Mmus TTVILVK-SMLRKRSFGNPFEPQA----------------RREERSMSAPGSLLMKEGCG ckk-1_Cele DTLILVK-AMGHRKRFGNPFRNKLSAQS-SI-------RDRRKSSSVKDPT--------- CaMKK1_Hsap TTVILVK-SMLRKRSFGNPFEPQA----------------RREERSMSAPGNLLVKEGFG CaMKK2_Hsap ATVILVK-TMIRKRSFGNPFEG-S----------------RREERSLSAPGNLLTKKPTR DDB0220010_Ddis NTTTDEDDSDLSSSSGGESSGI---------------IGSSNESKSMYNN--VNSKQKIQ CAMKK_Spur ETLILVK-NMLKTRSFHNPYRN-S----------------RKGRFALSSLGSSVDSK--- AqueK153_Aque HILVMIK-KMAKKKSLRNPYGVSDSPSVS------------------------------- . :. CG17698_Dmel ------------ARKKHSFGNPFVKGCSGTSSSLA-GCSRIERFIRAGRSNSAPGSYHMS CAMKK2_Mmus EW--EPLSEPKEARQRRQPPGPRAGPCGGGGSALVKGGPCVESWG-----APAPGSPPR- CAMKK1_Mmus E----------------------------------------------------GCKSPE- ckk-1_Cele --------------------------------------------Y-----VPPPNSPPAT CaMKK1_Hsap E----------------------------------------------------GGKSPE- CaMKK2_Hsap EC--ESLSELKEARQRRQPPGHRPAPRGGGGSALVRGSPCVESCW-----APAPGSPAR- DDB0220010_Ddis NQNQNQNQNQNQNQNQNQNQNHNQN-QNQNQNQNNNNNSLIEKSN-----ISIPASSSSI CAMKK_Spur ------------------------------------------------------------ AqueK153_Aque --------PCVSPRQHRRPPSFE----------------------NEGRS-------DS- CG17698_Dmel T--------ARQPS---SDTL-----------------LPSLMEH--------------- CAMKK2_Mmus --------------------------------------MPP------------------- CAMKK1_Mmus --------------------------------------LPG------------------- ckk-1_Cele SNNNLNSTKVDRPEIKCIEMN-----------------LSGLTLK--------------- CaMKK1_Hsap --------------------------------------LPG------------------- CaMKK2_Hsap --------------------------------------MHP------------------- DDB0220010_Ddis SNND-SCYENRNVYIKDEEMNMICNDSVIMDPIKELNKIDGLNYGCDFQIGKEYSDFQYN CAMKK_Spur ------------------------------------------------------------ AqueK153_Aque ------ISQVEKQKLFAAMKT-----------------IPTI--S--------------- CG17698_Dmel --------CST-----------------Q-CNEGTHS--FDY CAMKK2_Mmus --------------------------------LQPEEVMEPE CAMKK1_Mmus --------------------------------VQEDE--AAS ckk-1_Cele --------VDE-----------------A-MQSKVES--ARQ CaMKK1_Hsap --------------------------------VQEDE--AAS CaMKK2_Hsap --------------------------------LRPEEAMEPE DDB0220010_Ddis SGHFIYDLVDENESQISRESANDYYLPFKTNKYLNNK--SIV CAMKK_Spur ----------------------------------PEA--TVK AqueK153_Aque --------ISG-----------------E-DDEYTPQ--NET