CLUSTAL W (1.83) multiple sequence alignment CDK11a_Hsap MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEI CDK11b_Hsap MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEI CDK11_Mmus MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEI CDK11_d_Smoe ------------------------------------------------------------ CDK11_b-2_Smoe MHLVRG------MD----LD-RDRPDNERNGVRAYIATDSRDIE---------------- CDK11_a-2_Smoe MSWVMD--------E------------------RSTSSRHRKSHRYSH------------ CDK11_b-1_Smoe MHLVRG------MD----LD-RDRPDNERNGVRAYIATDSRDVE---------------- CDK11_a-1_Smoe MSWVMD--------E------------------RSTSSRHRKSHRYSH------------ CDK11_c_Smoe MQRR-------------------------------------------------------- CDK11a_Hsap TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKAHHRKDEKRKEKRRHRSHSAEGGK CDK11b_Hsap TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKCRHHSHSAEGGK CDK11_Mmus TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKAHHRKDEKRKEKRRHRSHSAEGGK CDK11_d_Smoe ------------------------------------------------------------ CDK11_b-2_Smoe ------------------------------------------------------GDDGIS CDK11_a-2_Smoe ----------------------------------------GDGRHHPYSHHHSSSSGGGS CDK11_b-1_Smoe ------------------------------------------------------GDDGIS CDK11_a-1_Smoe ----------------------------------------GDGRHHPYSHHHSSSSGGGS CDK11_c_Smoe ------------------------------------------------------------ CDK11a_Hsap HARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERK CDK11b_Hsap HARVK--EREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERK CDK11_Mmus HARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERK CDK11_d_Smoe ------------------------------------------------------------ CDK11_b-2_Smoe -------------RKRKY------------------------------------------ CDK11_a-2_Smoe -------------RRRHR------------------------------------------ CDK11_b-1_Smoe -------------RKRKY------------------------------------------ CDK11_a-1_Smoe -------------RRRHR------------------------------------------ CDK11_c_Smoe ------------------------------------------------------------ CDK11a_Hsap MREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPR CDK11b_Hsap MREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPR CDK11_Mmus LREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREEYSDKGKVGHWSRSPLRPPR CDK11_d_Smoe ------------------------------------------------------------ CDK11_b-2_Smoe ---------------------------------------------------SPI------ CDK11_a-2_Smoe ---------------------------------------------------SPSPSKPLA CDK11_b-1_Smoe ---------------------------------------------------SPI------ CDK11_a-1_Smoe ---------------------------------------------------SPSPSKPLA CDK11_c_Smoe ------------------------------------------------------------ CDK11a_Hsap ER-FELGDGRKPGEARPAPAQ-KPAQLKEEKMEERDLLSDLQDISDSERKTSSAESSSAE CDK11b_Hsap ER-FELGDGRKPGEARPAPAQ-KPAQLKEEKMEERDLLSDLQDISDSERKTSSAESSSAE CDK11_Mmus ER-FEMGDNRKP--------------VKEEKVEERDLLSDLQDISDSERKTSSAESSSAE CDK11_d_Smoe ------------------------------------------------------------ CDK11_b-2_Smoe --VWDLDDGKKSDAAPPLSRFSEAAAAGEDET----------QPIDTD--VLSSGGGGAQ CDK11_a-2_Smoe TSLLQLEEQLTTAQ-----AQ-APAT-------------------TSQERAASVSCSDGE CDK11_b-1_Smoe --VWDLDDGRKSDAAPPLSRFSEAAAAGEDET----------QPIDTD--VLSSGGGCAQ CDK11_a-1_Smoe TSLLQLEEQLTSAQ-----AQ-APAT-------------------TSQERAASVSCSDGE CDK11_c_Smoe ----------------P-CLYSEAAAAGEDET----------QPIDTD--VLSSGGG--- CDK11a_Hsap SGSGSEEEEEEEE-EEEEEGSTSEESEEEEEE-EEEEEEETGSNSEEASEQSAEEVSEE- CDK11b_Hsap SGSGSEEEEEEEE-EEEEEGSTSEESEEEEEE-EEEEEEETGSNSEEASEQSAEEVSEE- CDK11_Mmus SGSGSEEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEEETGSNSEEASEQSAEEVSDE- CDK11_d_Smoe ------------------------------------------------------------ CDK11_b-2_Smoe DNSGSRDEEQRYEQ-EL-------------------------------NEKELVELSDD- CDK11_a-2_Smoe VAAVVTLEVADLEEE-----------------VVNEEAE--------MSEVKVVDVAETS CDK11_b-1_Smoe DNSGSRDEEQRYEQ-EL-------------------------------NEKELVELSDD- CDK11_a-1_Smoe VAAAVTLEVADLEEE-----------------VVNEEAE--------MSEVKVVDVAETS CDK11_c_Smoe ----DKT------------------------------------------------IPGA- CDK11a_Hsap --EMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPAL CDK11b_Hsap --EMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPAL CDK11_Mmus --EMSEDEDRENENHILVVPESRFDRDSGDSEEGEEEVGEGTPQSSAPTEGDYVPDSPAL CDK11_d_Smoe ------------------------------------------------------------ CDK11_b-2_Smoe --DGSAPDERS-------------G-SDSDYE-------------------DRSP-PPQL CDK11_a-2_Smoe EAGLAKLD------------------DDGDLE-------------------QGVPHTPEV CDK11_b-1_Smoe --DGSAPDERS-------------G-SDSDYD-------------------DRSP-PPQL CDK11_a-1_Smoe EAGLAKPD------------------DDGDLE-------------------QGVPHTPEV CDK11_c_Smoe --EMRSSDERL-------------G-SDLDYD-------------------DRSP-PPQL CDK11a_Hsap SPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKME- CDK11b_Hsap LPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKME- CDK11_Mmus SPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKME- CDK11_d_Smoe --------------MLRGCRSVDEFERLNKIDEGTCGVVYRARDKKSGEIVALKRVKMD- CDK11_b-2_Smoe RSI----------DMLRGCRSVDEFERLNKIDEGTYGVVYRARDKKSGEIVALKRVKMD- CDK11_a-2_Smoe QDVKC-------SSPCGKCRIVDEFEKLGRLGEGAYGVVYKARDKRTEEIVALKKIKMHN CDK11_b-1_Smoe RSI----------DMLRGCRSVDEFERLNKIDEGTYGVVYRARDKKSGEIVALKRVKMD- CDK11_a-1_Smoe QDVKC-------SSPCGKCRIVDEFEKLGRLGEGAYGVVYKARDKRTEEIVALKKIKMHN CDK11_c_Smoe RSI----------DMLRGCRSVDEFERLNKIDEGTYGVLYRARDKKSGEIVALKRVKMV- ** *:**: *.:: **: **:*:*:**:: ******::** CDK11a_Hsap KEKEGFPITSLREINT-----------------------ILKAQHPNIVTVREIVV---- CDK11b_Hsap KEKEGFPITSLREINT-----------------------ILKAQHPNIVTVREIVV---- CDK11_Mmus KEKEGFPITSLREINT-----------------------ILKAQHPNIVTVREIVV---- CDK11_d_Smoe HEREGFPMTSVREINV-----------------------LLSFHHPSIVDVKEVSL---- CDK11_b-2_Smoe HEREGFPMTSLREINV-----------------------LLSFHHPSIVDVKEVVV---- CDK11_a-2_Smoe QETEGFPVTSLREINL-----------------------LISLRHPAIVDVREVVI---- CDK11_b-1_Smoe HEREGFPMTSLREINV-----------------------LLSFHHPSIVDVKEVVV---- CDK11_a-1_Smoe QETEGFPVTSLREINL-----------------------LISLRHPAIVDVREVVI---- CDK11_c_Smoe HERDGFPMTSRKSTFFSRFTIHRSWMSRKWWSHALQRNDQCSFNASSICTTTDQALLWNL :* :***:** :. . . . * . : : CDK11a_Hsap ---------------------------GSNMDK----IYIVMNYVEHDLKSLMETMKQPF CDK11b_Hsap ---------------------------GSNMDK----IYIVMNYVEHDLKSLMETMKQPF CDK11_Mmus ---------------------------GSNMDK----IYIVMNYVEHDLKSLMETMKQPF CDK11_d_Smoe ---------------------------MPYKAM----TSALS------------------ CDK11_b-2_Smoe ---------------------------GSNLDS----IFMVMEYMEHDLKGLMDAMKQPF CDK11_a-2_Smoe ---------------------------GKDMDS----VFMVMEYIERNLKDVMAALPQPW CDK11_b-1_Smoe ---------------------------GSNLDS----IFMVMEYMEHDLKGLMDAMKQPF CDK11_a-1_Smoe ---------------------------GKDMDS----VFMVMEYIERNLKDVMAALPQPW CDK11_c_Smoe MTKKELGSLLPQALAEPMCRSGSDASAGRERDRGGVTRWRLLRLQRVDLEAKAGTGKKPT : CDK11a_Hsap LPGEVK--TLMIQL---LRGVKHLHDNW----ILHRDLKTSNLLLSHAGILKVGDFGLAR CDK11b_Hsap LPGEVK--TLMIQL---LRGVKHLHDNW----ILHRDLKTSNLLLSHAGILKVGDFGLAR CDK11_Mmus LPGEVK--TLMIQL---LSGVKHLHDNW----ILHRDLKTSNLLLSHAGILKVGDFGLAR CDK11_d_Smoe ---------------------EYLH----------------------------------- CDK11_b-2_Smoe TQSEAK--CLMLQL---FEGVKYLHDNW----VLHRDLKTSNLLLNNRGDLKICDFGLAR CDK11_a-2_Smoe EHAVVK--HMMQQL---LDAVAYLHANW----VLHRDLKPSNILVS-GGELKICDFGMAR CDK11_b-1_Smoe TQSEAK--CLMLQL---FEGVKYLHDNW----VLHRDLKTSNLLLNNRGDLKICDFGLAR CDK11_a-1_Smoe EHAVVK--HMMQQL---LDAVAYLHANW----VLHRDLKPSNILVS-GGELKICDFGMAR CDK11_c_Smoe PKQDKSNRAAQIQAPGDSRGAKGNRDPRDLRGRLCRILKRGRRIII-VGHLNISPYPIDS : CDK11a_Hsap EYGSPLKAYTPVVVTLWYRAPELLL--------------------------GAKE----Y CDK11b_Hsap EYGSPLKAYTPVVVTQWYRAPELLL--------------------------GAKE----Y CDK11_Mmus EYGSPLKAYTPVVVTLWYRAPELLL--------------------------GAKE----Y CDK11_d_Smoe ------------------------------------------------------------ CDK11_b-2_Smoe QYGSPLKTYTRMVVTLWYRAPELLL--------------------------GSKK----Y CDK11_a-2_Smoe RYDSPIKAYTHKVVTMWYRAPELLA--------------------------STQEEQYHY CDK11_b-1_Smoe QYGSPLKTYTRMVVTLWYRAPELLL--------------------------GSKK----Y CDK11_a-1_Smoe RYDSPIKAYTHKVVTMWYRAPELLA--------------------------STQEEQYHY CDK11_c_Smoe --CDPGPKFDTDPSRQWFRSLLVSEGGAFSDSFRVFHPEIAEAYTCWSQASGAEE--FNY CDK11a_Hsap STAVDMWSVGCIFGELLTQKP-----LFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPA CDK11b_Hsap STAVDMWSVGCIFGELLTQKP-----LFPGNSEIDQINKVFKELGTPSEKIWPGYSELPV CDK11_Mmus STAVDMWSVGCIFGELLTQKP-----LFPGKSDIDQINKIFKDLGTPSEKIWPGYNDLPA CDK11_d_Smoe ------------------------------------------------------------ CDK11_b-2_Smoe NAAIDMWSLGCIMAEFLAKEP-----LFTGKSEIDQLDKIFKTLGTPNEKIWPNFVNLPG CDK11_a-2_Smoe TAAVDVWSLGCIMAELILNET-----LFQGTSEIDQLRRIKKMVWTAQL-EKPGF----- CDK11_b-1_Smoe NAAIDMWSLGCIMAEFLAKEP-----LFTGKSEIDQLDKIFKTLGTPNEKIWPNFVNLPG CDK11_a-1_Smoe TAAVDVWSLGCIMAELILNET-----LFQGTSEIDQLRRIKKMVWTAQL-EKPGF----- CDK11_c_Smoe GSRIDHVLI---------AGPCAGHCQCPDGSHENSSCDGFAECGTDMCDILLEFKRAK- CDK11a_Hsap VKKMTFSEHPYNNLRKRF--------GALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEY CDK11b_Hsap VKKMTFSEHPYNNLRKRF--------GALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEY CDK11_Mmus VKKMTFSEYPYNNLRKRF--------GALLSDQGFDLMNKFLTYYPGRRINAEDGLKHEY CDK11_d_Smoe ------------------------------------------------------------ CDK11_b-2_Smoe VK-CNFVRQPYNRLREKFP-PVAFGGRPALSEKGYDLLNKLLTYDPSKRITAEEALNHEW CDK11_a-2_Smoe ----IFPAHKLSALRDRILYPAAQAGRPMLSEKGLDLLAQLLAYDPDKRISASAALAHPW CDK11_b-1_Smoe VK-CNFVRQPYNRLREKFP-PVAFGGRPALSEKGYDLLNKLLTYDPSKRITAEEALNHEW CDK11_a-1_Smoe ----IFPAHKLSALRDRILYPAAQAGRPMLSEKGLDLLAQLLAYDPDKRISANAALAHPW CDK11_c_Smoe LDTLPRSRSCYSALKHYLP--------FHHMKLHNWLLDLCLSFALLRKVSVRNGQ-QET CDK11a_Hsap FRETPLPIDPS------------------------------------------------- CDK11b_Hsap FRETPLPIDPS------------------------------------------------- CDK11_Mmus FRETPLPIDPS------------------------------------------------- CDK11_d_Smoe ------------------------------------------------------------ CDK11_b-2_Smoe FDEVPLPKMKE------------------------------------------------- CDK11_a-2_Smoe FQEPPLPTPPP------------------------------------------------- CDK11_b-1_Smoe FDEVPLPKMKE------------------------------------------------- CDK11_a-1_Smoe FQEPPLPTPPP------------------------------------------------- CDK11_c_Smoe TEAVTKPIDRVLLSKHESSDKMSCTEVAVHGQSSSLTDEIQQSAESCDNNNCSEVAPCGE CDK11a_Hsap ------MFPTWPAKSEQQRV-KRG-TSPRPPEGGLGYSQLGDDDLKE------------- CDK11b_Hsap ------MFPTWPAKSEQQRV-KRG-TSPRPPEGGLGYSQLGDDDLKE------------- CDK11_Mmus ------MFPTWPAKSEQQRV-KRG-TSPRPPEGGLGYSQLGDDDLKE------------- CDK11_d_Smoe ------------------------------------------------------------ CDK11_b-2_Smoe ------LMPTFPVRSDQDRRLRRAMKSPDPLEEQRRRELRGE------------------ CDK11_a-2_Smoe ------PLPAPPLAATM------------------------------------------- CDK11_b-1_Smoe ------LMPTFPVRSDQDRRLRRAMKSPDPLEEQRRRELRGE------------------ CDK11_a-1_Smoe ------PLPALPLAATM------------------------------------------- CDK11_c_Smoe SAILMDMSDETPTESSQQSL-EKLAAGWERLKSLMSRNLLSCKGHGETCVVRTVKKAGPN CDK11a_Hsap --TGFHLTTTNQGASAAGPGFSLKF CDK11b_Hsap --TGFHLTTTNQGASAAGPGFSLKF CDK11_Mmus --TGFHLTTTNQGASAAGPGFSLKF CDK11_d_Smoe -----------------------DD CDK11_b-2_Smoe ------------------FGAGVFG CDK11_a-2_Smoe ----------------------PLQ CDK11_b-1_Smoe ------------------FGAGVFG CDK11_a-1_Smoe ----------------------PLQ CDK11_c_Smoe LGRGFYVCTRAKGPAS---THKLGI