CLUSTAL W (1.83) multiple sequence alignment Cdk5_Dmel -------MQ---KY----------DKMEKIGEGTYGTVFKGRNRDTMEIVALKRVRLDED CDK5_Mmus -------MQ---KY----------EKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDD cdk-5_Cele -------ML---NY----------DKMEKIGEGTYGTVFKARNKNSGEIVALKRVRLDDD CDK5_Hsap -------MQ---KY----------EKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDD Cdk5_Ddis -------ME---KY----------SKIEKLGEGTYGIVYKAKNRETGEIVALKRIRLDSE PHO85_Scer -------MSSSSQF----------KQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDS- 9119_Tthe MVMKNSKLE---RY----------EKLNKLGEGTYGVVYKAREKTTKELYALKKIRLESE CDK5_Spur -------MA---SHYCMRQRSTEAKEYYTTAERTYGTVFKAKNRETQEIVALKRVRLDDD CC1G_03767_Ccin -------MM---NY----------IQLEKLGEGTYATVYKGRSRTTNEIVALKEIHLDA- AqueK097_Aque -------ME---KY----------ERLEKIGEGTYGTVFKAKEKESGEIVALKIVRLDED GK023_Glam MTD---PLN---RY----------ERIQGLGEGTYGVVFKAKDKETGQIVALKRIRLENA : . . .: **. *:*. .: : *** ::*: Cdk5_Dmel DEGVPSSALREICLLKELKHKNIVRLIDVLHSDKKLTLVFEHCDQDLKKYFDSLN----- CDK5_Mmus DEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCN----- cdk-5_Cele DEGVPSSALREICILRELKHRNVVRLYDVVHSENKLTLVFEYCDQDLKKFFDSLN----- CDK5_Hsap DEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCN----- Cdk5_Ddis DEGVPCTAIREISLLKELKHPNIVRLHDVIHTERKLTLVFEYLDQDLKKYLDECG----- PHO85_Scer EEGTPSTAIREISLMKELKHENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTP 9119_Tthe DEGIPSTAIREISLLKELQHPNVVRLHDVIHSNKKLVLVFEFVDQDLKKFMNNFKD---- CDK5_Spur DE---------------------------------------------------------- CC1G_03767_Ccin EEGTPSTAIREISLMKELKHVNIVRLHDVIHTETKLVLIFEYCEQDLKKYMDQHGER--- AqueK097_Aque DEGVPSAALREICLLKELKHKNIVRLTDVLHKNLKLTMVFEYIDQDLKKYFDVSG----- GK023_Glam DEGIPATAIREIAILKEMKHKNVVDLLSVIHTEAKLTLVFEYLDMDLKKYIDSKQ----- :* Cdk5_Dmel GEIDMAVCRSFMLQLLRGLAFCHSHNVLHRDLKPQNLLINKNGELKLADFGLARAFGIPV CDK5_Mmus GDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPV cdk-5_Cele GYMDAQTARSLMLQLLRGLSFCHAHHVLHRDLKPQNLLINTNGTLKLADFGLARAFGVPV CDK5_Hsap GDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPV Cdk5_Ddis GEISKPTIKSFMYQLLKGVAFCHDHRVLHRDLKPQNLLINRKGELKLADFGLARAFGIPV PHO85_Scer RGLELNLVKYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPV 9119_Tthe KGLDPHIIKSLLYQLLKGIEVCHKNKILHRDLKPQNLLISKECILKLADFGLARASGIPV CDK5_Spur ---------SFMYQLLRGLAFCHSHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPV CC1G_03767_Ccin GALEPEVVRSFMYQLLKGTAFCHENQVLHRDLKPQNLLINRKGELKLGDFGLARAFGVPV AqueK097_Aque GIISPQVVQSFFFQLLQGLAFCHYNNILHRDLKPQNILISKKGDLKLADFGLARAFGIPV GK023_Glam GKLTPKEVKSFMGQLMTGLTYIHNKRVLHRDLKPQNLLVTSSGLLKLADFGLARGSGIPV : **: * * ..:*********:*:. ***.******. *:** Cdk5_Dmel KCYSAEVVTLWYRPPDVLFGAKLYTTSIDMWSAGCILAELADAGRPLFPGSDVLDQLMKI CDK5_Mmus RCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRI cdk-5_Cele RCFSAEVVTLWYRPPDVLFGAKLYNTSIDMWSAGCIFAEISNAGRPLFPGADVDDQLKRI CDK5_Hsap RCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRI Cdk5_Ddis RTYSHEVVTLWYRAPDVLMGSRKYSTPIDIWSAGCIFAEMA-SGRPLFPGSGTSDQLFRI PHO85_Scer NTFSSEVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMI-TGKPLFPGTNDEEQLKLI 9119_Tthe KNYTHEVVTLWYRPPDVLLGSKHYSTSIDIWSIGCIFAEMV-NLKPLFPGNSETDELKRI CDK5_Spur RCYSAEVVTLWYRPPDVLFGAKVYTTSIDMWSAGCIFAEMANAGRPLFPGNDVEDQLKRI CC1G_03767_Ccin NTFSNEVVTLWYRAPDVLLGSRTYSTSIDVWSCGCIFAEMI-SGVPLFRGRDNQDQLLHI AqueK097_Aque RLFSAEVVTLWYRPPDVLMGAQVYNTSIDMWSAGTIFAELANAGRPLFPGSDVDEQLKRI GK023_Glam RSYTHEVVTLWYRCPSVLLGCRKYGGALDIWSCGCIFYECV-TGKPLFPAKTEKDELIKI . :: ******** *.**:*.: * .:*:** * *: * *** . ::* * Cdk5_Dmel FRVLGTPNEDSWPGVSH-LSDYVA--LPSFPAITSWSQLVP-----RLNSKGRDLLQKLL CDK5_Mmus FRLLGTPTEEQWPAMTK-LPDYKP--YPMYPATTSLVNVVP-----KLNATGRDLLQNLL cdk-5_Cele FKQLGSPSEDNWPSITQ-LPDYKP--YPIYHPTLTWSQIVP-----NLNSRGRDLLQKLL CDK5_Hsap FRLLGTPTEEQWPSMTK-LPDYKP--YPMYPATTSLVNVVP-----KLNATGRDLLQNLL Cdk5_Ddis FKILGTPNEESWPSITE-LPEYKTD-FPVHPA-HQLSSIVH-----GLDEKGLNLLSKML PHO85_Scer FDIMGTPNESLWPSVTK-LPKYNP-NIQQRPP-RDLRQVLQPHTKEPLDGNLMDFLHGLL 9119_Tthe FKLTGTPCVEKWPGLAD-LPNWKADAFEKYPG-EPLQNICP-----KLDELGLDLLGKML CDK5_Spur FKLLGTPTEDTWPGISK-LPDFKP--YPIYPVTTPLASVVP-----SLSATGRDLLQRLM CC1G_03767_Ccin MRIIGTPSPAQFAKICKETPEIQPKQFPNYPR-LPFHQVLP-----KASPQALDLLDKLL AqueK097_Aque FKLVGTPTERSWPGLTK-LPEFKE--FPPYPP-ACIESVVP-----ALNDAGVDLLQRHL GK023_Glam FKTLGTPDKQSWPDVDT-LPQWQK-DFPVYPG-INVAELLP-----TLDEAGRDLFSKMM : *:* :. : .. .: . ::: : Cdk5_Dmel ICRPNQRISAEAAMQHPYFTDSSS------------------------------------ CDK5_Mmus KCNPVQRISAEEALQHPYFSDFC------------------------------------- cdk-5_Cele VCNPAGRIDADAALRHAYFADTS------------------------------------- CDK5_Hsap KCNPVQRISAEEALQHPYFSDFC------------------------------------- Cdk5_Ddis QYDPNQRITAAAALKHPYFDGLEP------------------------------------ PHO85_Scer QLNPDMRLSAKQALHHPWFAEYYH------------------------------------ 9119_Tthe RCNPQERITAKAGLEHPYFNDIPDTLKKMNMRMLSYQLVIFNKRLINKIKSPKTIKCNYF CDK5_Spur MCNPALRMSAEEGLMHQYFADLNS------------------------------------ CC1G_03767_Ccin KFDPAERISAADALAHPYFTTATNTPFGLN-------------------SSPSSMPPPSF AqueK097_Aque ICHPTERISAEEAMRHEYFADIDPS----------------------------------- GK023_Glam ALDPSKRPSARDCLKHPYFA---------------------------------------- * * * : * :* Cdk5_Dmel ------------------------------------------------------------ CDK5_Mmus ------------------------------------------------------------ cdk-5_Cele ------------------------------------------------------------ CDK5_Hsap ------------------------------------------------------------ Cdk5_Ddis ------------------------------------------------------------ PHO85_Scer ------------------------------------------------------------ 9119_Tthe DRKKSYIQKEKERDQLSKQEDIDRRKNIVSKLGNLASNVHILNKQIASFSVWKNPTNYLP CDK5_Spur ------------------------------------------------------------ CC1G_03767_Ccin NFPHSHVHQAQQQHQQRQQQQQQQQ----------------------------------- AqueK097_Aque ------------------------------------------------------------ GK023_Glam ------------------------------------------------------------ Cdk5_Dmel ------------------------------------------------------------ CDK5_Mmus ------------------------------------------------------------ cdk-5_Cele ------------------------------------------------------------ CDK5_Hsap ------------------------------------------------------------ Cdk5_Ddis ------------------------------------------------------------ PHO85_Scer ------------------------------------------------------------ 9119_Tthe EKAKFPSPKELFPKDNENSWKTLNDLTPSLFKDVQGFKEKQVQRAAYMQIAKPNGQMYHI CDK5_Spur ------------------------------------------------------------ CC1G_03767_Ccin ----------------------------------QQQQQQQQQQQVHHQQIQPHYS---- AqueK097_Aque ------------------------------------------------------------ GK023_Glam ------------------------------------------------------------ Cdk5_Dmel ------------------------------------------------------------ CDK5_Mmus ------------------------------------------------------------ cdk-5_Cele ------------------------------------------------------------ CDK5_Hsap ------------------------------------------------------------ Cdk5_Ddis ------------------------------------------------------------ PHO85_Scer ------------------------------------------------------------ 9119_Tthe FDASKMPLGRMCQKIAFFLQGKHRPTFKNCDQVTYDNIIVVNAANIMLTGKKALLKTVKY CDK5_Spur ------------------------------------------------------------ CC1G_03767_Ccin -----------------------R------------------------------------ AqueK097_Aque ------------------------------------------------------------ GK023_Glam ------------------------------------------------------------ Cdk5_Dmel ------------------------------------------------------------ CDK5_Mmus ------------------------------------------------------------ cdk-5_Cele ------------------------------------------------------------ CDK5_Hsap ------------------------------------------------------------ Cdk5_Ddis ------------------------------------------------------------ PHO85_Scer ------------------------------------------------------------ 9119_Tthe HTGFVGGLKEKSYKFFLTEKPEQLVNIYIQLVSKVFYCISKMLPKNLKRRDLLKKVEIYR CDK5_Spur ------------------------------------------------------------ CC1G_03767_Ccin --------------------------------------------------------PIYG AqueK097_Aque ------------------------------------------------------------ GK023_Glam ------------------------------------------------------------ Cdk5_Dmel ------------------------------------------------------------ CDK5_Mmus ------------------------------------------------------------ cdk-5_Cele ------------------------------------------------------------ CDK5_Hsap ------------------------------------------------------------ Cdk5_Ddis ------------------------------------------------------------ PHO85_Scer ------------------------------------------------------------ 9119_Tthe DFQHEKQGLPNVIQVKINYASFILNSLIELIQFVPYTEKETFDQYFNPFVHNFEDLVIKF CDK5_Spur ------------------------------------------------------------ CC1G_03767_Ccin QIPQHPQNPAQVKNVQVPYGN---------VQYPPY------------------------ AqueK097_Aque ------------------------------------------------------------ GK023_Glam ------------------------------------------------------------ Cdk5_Dmel ------------------------------------------------------------ CDK5_Mmus ------------------------------------------------------------ cdk-5_Cele ------------------------------------------------------------ CDK5_Hsap ------------------------------------------------------------ Cdk5_Ddis ------------------------------------------------------------ PHO85_Scer ------------------------------------------------------------ 9119_Tthe QSSKETPKELEGIKKEIDPEITLPFNQRSKIFKLNAHNRRVMKQWKMYYRRLRRYKVHKI CDK5_Spur ------------------------------------------------------------ CC1G_03767_Ccin ------------------------------------------------------------ AqueK097_Aque ------------------------------------------------------------ GK023_Glam ------------------------------------------------------------ Cdk5_Dmel ------------------------------------------------------------ CDK5_Mmus ------------------------------------------------------------ cdk-5_Cele ------------------------------------------------------------ CDK5_Hsap ------------------------------------------------------------ Cdk5_Ddis ------------------------------------------------------------ PHO85_Scer ------------------------------------------------------------ 9119_Tthe KAPKNRDPNLSNKSFMITSDRQIKDFNLHNRIVPEEVPEDDDEIMRTIPRQGGGSATAGP CDK5_Spur ------------------------------------------------------------ CC1G_03767_Ccin ------------------------------------------------------------ AqueK097_Aque ------------------------------------------------------------ GK023_Glam ------------------------------------------------------------ Cdk5_Dmel ---------------------SGH CDK5_Mmus ----------------------PP cdk-5_Cele ----------------------DV CDK5_Hsap ----------------------PP Cdk5_Ddis ----------------------IN PHO85_Scer ---------------------HAS 9119_Tthe AKPAGGNANAGAAAAKGGKQGGKK CDK5_Spur ---------------------VVN CC1G_03767_Ccin -------------------GAPPR AqueK097_Aque ---------------------LRA GK023_Glam -----------------------K