CLUSTAL W (1.83) multiple sequence alignment Cdk7_Dmel MLPNAN---DKT------------------------------------------------ CDK7_Mmus MAVDVK---SRA------------------------------------------------ cdk-7_Cele M----------S------------------------------------------------ KIN28_Scer MKV--------N------------------------------------------------ CDK7_Hsap MALDVK---SRA------------------------------------------------ Cdk7_Ddis M----------------------------------------------------------- CDK7_Spur MEAWK----ANAEKEEESFLKILHSRMETSSAHGLPNIHRSSKSITKLFWLLLFLTGIGV CC1G_00997_Ccin MDIVEQANAERQ------------------------------------------------ AqueK098_Aque M----------S------------------------------------------------ CDK7-2_Smoe MLEL--KNGIGA------------------------------------------------ CDK7-1_Smoe MLEL--KNGIGA------------------------------------------------ * Cdk7_Dmel ------------------------------------------------------------ CDK7_Mmus ------------------------------------------------------------ cdk-7_Cele ------------------------------------------------------------ KIN28_Scer ------------------------------------------------------------ CDK7_Hsap ------------------------------------------------------------ Cdk7_Ddis ------------------------------------------------------------ CDK7_Spur ITWQVIALFKTYFAYEYTVSLEIKFNRSQEFPAITICNMNPVMKSKLEKADDSFRELFDT CC1G_00997_Ccin ------------------------------------------------------------ AqueK098_Aque ------------------------------------------------------------ CDK7-2_Smoe ------------------------------------------------------------ CDK7-1_Smoe ------------------------------------------------------------ Cdk7_Dmel ------------------------------------------------------------ CDK7_Mmus ------------------------------------------------------------ cdk-7_Cele ------------------------------------------------------------ KIN28_Scer ------------------------------------------------------------ CDK7_Hsap ------------------------------------------------------------ Cdk7_Ddis ------------------------------------------------------------ CDK7_Spur NFQPPGPMDMVDQVVQGVGQVGGVFSSGVGSFMGSGGNSGGGVEANNAKTTQRPGSSTAG CC1G_00997_Ccin ------------------------------------------------------------ AqueK098_Aque ------------------------------------------------------------ CDK7-2_Smoe ------------------------------------------------------------ CDK7-1_Smoe ------------------------------------------------------------ Cdk7_Dmel -----------------------------------------------ER----------- CDK7_Mmus -----------------------------------------------KR----------- cdk-7_Cele -----------------------------------------------RR----------- KIN28_Scer -----------------------------------------------ME----------- CDK7_Hsap -----------------------------------------------KR----------- Cdk7_Ddis -----------------------------------------------DK----------- CDK7_Spur GRRATDGNVEVAGSVEPPNGPSGPLSSQALCSRHQASGQPPNLREIQQRYGVRNLRGGSM CC1G_00997_Ccin -----------------------------------------------RK----------- AqueK098_Aque -----------------------------------------------KR----------- CDK7-2_Smoe -----------------------------------------------KR----------- CDK7-1_Smoe -----------------------------------------------KR----------- . Cdk7_Dmel ------------------------------------------------------------ CDK7_Mmus ------------------------------------------------------------ cdk-7_Cele ------------------------------------------------------------ KIN28_Scer ------------------------------------------------------------ CDK7_Hsap ------------------------------------------------------------ Cdk7_Ddis ------------------------------------------------------------ CDK7_Spur DLYKKGEMSANRGPTQKSMTSKKGVRTLCSPSLYLPLTLSHYVGFRSDLFRGRPSFGCSR CC1G_00997_Ccin ------------------------------------------------------------ AqueK098_Aque ------------------------------------------------------------ CDK7-2_Smoe ------------------------------------------------------------ CDK7-1_Smoe ------------------------------------------------------------ Cdk7_Dmel ------------------------------------------------------------ CDK7_Mmus ------------------------------------------------------------ cdk-7_Cele ------------------------------------------------------------ KIN28_Scer ------------------------------------------------------------ CDK7_Hsap ------------------------------------------------------------ Cdk7_Ddis ------------------------------------------------------------ CDK7_Spur ANTSITPTRPTRPITDRAKTYITRPSRESVGFEIGLKAVETWQDRQKGDFFRKQSNDYLK CC1G_00997_Ccin ------------------------------------------------------------ AqueK098_Aque ------------------------------------------------------------ CDK7-2_Smoe ------------------------------------------------------------ CDK7-1_Smoe ------------------------------------------------------------ Cdk7_Dmel ------------------------------------------------------------ CDK7_Mmus ------------------------------------------------------------ cdk-7_Cele ------------------------------------------------------------ KIN28_Scer ------------------------------------------------------------ CDK7_Hsap ------------------------------------------------------------ Cdk7_Ddis ------------------------------------------------------------ CDK7_Spur QQRLMVKLANKTIEERKSLGHSLDDMLLDCSWRGFPCSPANFTNIFDPQFGNCYIFNSGL CC1G_00997_Ccin ------------------------------------------------------------ AqueK098_Aque ------------------------------------------------------------ CDK7-2_Smoe ------------------------------------------------------------ CDK7-1_Smoe ------------------------------------------------------------ Cdk7_Dmel ------------------------------------------------------------ CDK7_Mmus ------------------------------------------------------------ cdk-7_Cele ------------------------------------------------------------ KIN28_Scer ------------------------------------------------------------ CDK7_Hsap ------------------------------------------------------------ Cdk7_Ddis ------------------------------------------------------------ CDK7_Spur DGDTLTTNRPGPNYGLSMELFVQQDEYMEDQTEVAGFRVIIHHPSNMPFPSDDGIFVSPG CC1G_00997_Ccin ------------------------------------------------------------ AqueK098_Aque ------------------------------------------------------------ CDK7-2_Smoe ------------------------------------------------------------ CDK7-1_Smoe ------------------------------------------------------------ Cdk7_Dmel ------------------------------------------------------------ CDK7_Mmus ------------------------------------------------------------ cdk-7_Cele ------------------------------------------------------------ KIN28_Scer ------------------------------------------------------------ CDK7_Hsap ------------------------------------------------------------ Cdk7_Ddis ------------------------------------------------------------ CDK7_Spur MVTAIGVRVVTAIGVRVVEIERLPEPYGLCKEDTKENIEDNIYYQNYNMSYSIQKKLFEK CC1G_00997_Ccin ------------------------------------------------------------ AqueK098_Aque ------------------------------------------------------------ CDK7-2_Smoe ------------------------------------------------------------ CDK7-1_Smoe ------------------------------------------------------------ Cdk7_Dmel ------------------------------------YAKLSFLGEGQFATVYKARDTV-T CDK7_Mmus ------------------------------------YEKLDFLGEGQFATVYKARDKN-T cdk-7_Cele ------------------------------------YDTIKHLGEGQFANVYLAQDLE-S KIN28_Scer ------------------------------------YTKEKKVGEGTYAVVYLGCQHS-T CDK7_Hsap ------------------------------------YEKLDFLGEGQFATVYKARDKN-T Cdk7_Ddis ------------------------------------YNIEALIGEGTYGVVSRATVKA-T CDK7_Spur MIRSNEEMKRQIRGQSPSVWTRSNMAKLEIYFDEFNYEYIRQDPAYTFATVYKALDLQHD CC1G_00997_Ccin ------------------------------------WLKDRKVGEGAYAVVYQGREAS-T AqueK098_Aque ------------------------------------YRKLDILGEGQFATVYRAEDTERD CDK7-2_Smoe ------------------------------------YVKGISLGEGTYGVVFKALDTQ-T CDK7-1_Smoe ------------------------------------YVKGISLGEGTYGVVFKALDTQ-T : :. * . Cdk7_Dmel NQIVAVKKIKK-GSREDARDGINRTALREIKILQELQHENIIGLVDVFGQLSNVSLVFDF CDK7_Mmus NQIVAIKKIKL-GHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDF cdk-7_Cele GECVAIKKIKL-GSREEAKDGINRTAIREIKLLKEIHHDNIIGLRDVIGHRTSIQLVFDF KIN28_Scer GRKIAIKEIKT-S---EFKDGLDMSAIREVKYLQEMQHPNVIELIDIFMAYDNLNLVLEF CDK7_Hsap NQIVAIKKIKL-GHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDF Cdk7_Ddis GQIVAIKKIRKILIQNQTDDGINFSAIREIKILQELKHDNVVNLLDIFAHKSNVYLVFEL CDK7_Spur GKIVAVKKIKL-GHRSEAQDGINRTALREIKLLQEIKHENVIG----------------- CC1G_00997_Ccin GRKVAIKKIKV-G---QFKDGLDMSAIREVKFLRELKHQNVIELLDVFSSKKNLNLVLEF AqueK098_Aque NAIVAVKKIKI-GQRREARDGINRTALREIKLLQELHHPHILGLLDVLGHKSNISLIFDF CDK7-2_Smoe NRTVAVKKIRL-G---KYKEGVHVTALREIKLLKELRDPNIIELIDVYPHKRNLHLVFEF CDK7-1_Smoe NRTVAVKKIRL-G---KYKEGVHVTALREIKLLKELRDPNIIELIDVYPHKRNLHLVFEF . :*:*:*: . :*:. :*:**:* *:*: . ::: Cdk7_Dmel MDTDLEVIIKDNKIILTQANIKAYAIMTLKGLEYLHLNWILHRDLKPNNLLVNSDGILKI CDK7_Mmus METDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKL cdk-7_Cele MDTDLEHVIKDKEIILMPAHIKNITMQMLLGLEFLHVHWILHRDLKPNNLLMNKMGRVKL KIN28_Scer LPTDLEVVIKDKSILFTPADIKAWMLMTLRGVYHCHRNFILHRDLKPNNLLFSPDGQIKV CDK7_Hsap METDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKL Cdk7_Ddis MQWDLQEVIEDKSIILKPADIKSYMKMLLQGIEACHRNWVLHRDLKPNNLLMSINGDLKL CDK7_Spur ------VIIKDSSVVLTPSHIKAYTMMALRGLEYLHANWILHRDMKPNNLLLDENGVLKI CC1G_00997_Ccin LDTDLEIIIRDRSLVFLPADIKSWMAMTFRGLEFCHRNWILHRDLKPNNLLIASDGQLKI AqueK098_Aque MDTDLEMIIKDKSLLLPPGVVKAYSLMILQGLEYLHAHWILHRDLKPNNLLINKDGVLKI CDK7-2_Smoe MESDLEAVIRDRNILLSPADVKSYMQMCLRGLAHCHKKWVLHRDLKPNNLLISSDGQLKL CDK7-1_Smoe MESDLEAVIRDRNILLSPADVKSYMQMCLRGLAHCHKKWVLHRDLKPNNLLISSDGQLKL :*.* .::: . :* : *: * :::****:******. * :*: Cdk7_Dmel GDFGLAKSFGSPNRIYTHHVVTRWYRSPELLFGARQYGTGVDMWAVGCILAELMLRVPFM CDK7_Mmus ADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFL cdk-7_Cele TDFGLARFFGSPNRNYTHQVVTRWYRAPELLFGARSYGVGIDIWSVGCIIAELLLRNPIF KIN28_Scer ADFGLARAIPAPHEILTSNVVTRWYRAPELLFGAKHYTSAIDIWSVGVIFAELMLRIPYL CDK7_Hsap ADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFL Cdk7_Ddis ADFGLARQYGSPNKVFSPQAVTIFYRAPELLFGAKSYGPSVDIWSIGCIFAELMLRTPYL CDK7_Spur GDFGLAKFYGSPNRIYTHQVVTRWYRCPELLFGARIYGTGVDMWAMGCILAELLLRVPFL CC1G_00997_Ccin ADFGLARDFADPGYKMTCQVITRWYRPPELLYGCRYYGTGVDIWSVGCIFAELMLRIPYL AqueK098_Aque TDFGLAKAYGSPNRIMTHQVVTRWYRSPELLFGARLYSTGVDLWAVGCIIAEMLLRLPFL CDK7-2_Smoe GDFGLARIFGSPDRKFTHQVFARWYRSPELLFGSKQYGSGVDIWAAGCIFAELLLRRPFL CDK7-1_Smoe GDFGLARIFGSPDRKFTHQVFARWYRSPELLFGSKQYGSGVDIWAAGCIFAELLLRRPFL *****: * : :..: :** ****:*.: * .:*:*: * *:**::** * : Cdk7_Dmel PGDSDLDQLTRIFSTLGTPTEAEWPHLSKLHDYLQFRNF-PGT---PLDNIFTAAGNDLI CDK7_Mmus PGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSF-PGV---PLQHIFIAAGDDLL cdk-7_Cele PGESDIDQLVKIFNILGCPTPETWPNMTEMNSYVIIKPQTEYM---ALNYYFSAAPQDLL KIN28_Scer PGQNDVDQMEVTFRALGTPTDRDWPEVSSFMTYNKLQIY-PPPSRDELRKRFIAASEYAL CDK7_Hsap PGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSF-PGI---PLHHIFSAAGDDLL Cdk7_Ddis PGTGEIDQLRKICSALGTPNESNWPGVTCLPNYIKFTDH-PAT---PFKQLFTAASDEAI CDK7_Spur PGESDLDQLSRIFQTMGTPSEEEWPNMSALADYIEFKKF-PGT---PLRDIFTAGTDDLL CC1G_00997_Ccin AGESDMDQLKTIFRALGTPTEEEWPGHTKLPDYVPVGQF-PKT---PLRDLFTAASADAL AqueK098_Aque PGETDLGQLSTIFEFFGSPNEENWPSVKSLPDYVEFKPS-PPQ---SFRDVFSAAGDDLI CDK7-2_Smoe QGSSDIDQLGKIFQAFGTPRETQWPDMTSLPDYVEFQFT-PAP---ALRSLFPMATEDAL CDK7-1_Smoe QGSSDIDQLGKIFQAFGTPRETQWPDMTSLPDYVEFQFT-PAP---ALRSLFPMATEDAL * ::.*: :* * ** : * . : * . : Cdk7_Dmel HLMQRLFAMNPLRRVSCREALSMPYFANKPAPTVGPKLPMPSAILAAK-E-GANPQTGDT CDK7_Mmus ELIQGLFLFNPCTRTTASQALKTKYFSNRPGPTPGCQLPRPNCPVEALKE-PANPTV--- cdk-7_Cele DLMAGMWTFDPIKRLTCTQSLQMEYFRTQPFCCLDEELPLPKKQQ---------PQ---- KIN28_Scer DFMCGMLTMNPQKRWTAVQCLESDYFKELPPPSDPSSI---------------------- CDK7_Hsap DLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKE-QSNPAL--- Cdk7_Ddis DLISKMLLFNPSNRISAADALNHPYFTSGVKHTNPADLPVPFAKKASLL--QQRQVLAQV CDK7_Spur TLLKGLLLMDPCRRCKATEALKMPYFYTKPAPTPGHLLPRPGMVAAAANG-KQQPKL--- CC1G_00997_Ccin NLLSKCLVYEPRKRISAREALNHPYFFALPYPTHPSKLPKPASKHATPPLGEVDGNAAGG AqueK098_Aque HLLESCMKLDPSKRCTASQALQSSYFSNPPGPTPGPRLPMPRSRKEIEAD-IEHEIM--- CDK7-2_Smoe DLLSKMFAFDPKARITAQQALEHRYFSTDPAPTKAHLLLRPASKAEGMR--P-PPELASP CDK7-1_Smoe DLLSKMFAFDPKARITAQQALEHRYFSTDPAPTKAHLLLRPASKAEGMR--P-PPELASP :: :* * .. :.*. ** : Cdk7_Dmel K-P--ALKRKLVETTVRGN----------------------------------------- CDK7_Mmus -----ATKRKRAEALEQ------------------------------------------- cdk-7_Cele ------KRSRRLD--DDG------------------------------------------ KIN28_Scer ------------------------------------------------------------ CDK7_Hsap -----AIKRKRTEALEQ------------------------------------------- Cdk7_Ddis QQQLLQKQQQQQQQ-----------------------------Q---------------- CDK7_Spur -----GSKRKMADDIGTAAQCYLLGQQLKRHVLRIPEGVQNTYPLADGASCLLTPTEYGS CC1G_00997_Ccin KKR-KGTKRKLSSP------------------------------LEDG------------ AqueK098_Aque -----ASRKRALDDSQEG------------------------------------------ CDK7-2_Smoe KEPVVLSPPAKARRISL-FP----GVAG-------AEHIHHSKESKDGSSAA-TVGETPS CDK7-1_Smoe KEPVVLSPPAKARRISL-FP----GVAG-------AEHIHHSKESKDGSSAA-TVGETPS Cdk7_Dmel -------------------GLAQKKRLQ-F CDK7_Mmus --------------------GILPKKLI-F cdk-7_Cele --------------------TRPVRRLNFD KIN28_Scer ---------------K----------IR-N CDK7_Hsap --------------------GGLPKKLI-F Cdk7_Ddis ---QQQIQSQPEPI-QVDNVEQTQQAQQ-V CDK7_Spur YADGMFRMPGQYRLSHT-CAEVMPIAVR-L CC1G_00997_Ccin --------KGRSIARRLDFG-KAAPPTS-P AqueK098_Aque --------------------QKVAKRLN-F CDK7-2_Smoe DHSGMAITDRSYLKRKLDMDVHFEDERH-V CDK7-1_Smoe DHSGMAITDRSYLKRKLDMDVHFEDERH-V