CLUSTAL W (1.83) multiple sequence alignment Cdk9_Dmel MAHMSHMLQ--QPS-----------------------------G---------------- CDK9_Mmus MAKQ-------------------------------------------------------- H25P06.2_Cele MSAQNYHAGLHQSSTQRP-----PKRPNTEHAQEPPKRALIGGQ---------------- CDK9_Hsap MAKQ-------------------------------------------------------- CDK9_Spur MAESKGASF--SGT---------------------------------------------- SGV1_Scer MSDNGSPAVLPKTEFNKYKIGK--------------------VK---------------- CC1G_11325_Ccin MSLAPRLAP--APALNHPEIRRTTTRDGIEALQS-LNRGLVTTGSQPMTTIIAGGLGETA AqueK100_Aque MHLQV------------------------------------------------------- AqueK101_Aque MAGPV------------------------------------------------------- * Cdk9_Dmel ------------------------------------------------------------ CDK9_Mmus ------------------------------------------------------------ H25P06.2_Cele ------------------------------------------------------------ CDK9_Hsap ------------------------------------------------------------ CDK9_Spur ------------------------------------------------------------ SGV1_Scer ------------------------------------------------------------ CC1G_11325_Ccin GEIIEIEIFATDPQDGQWNAQGRHDETGTVFPSAILLPEVQNGVIHHHAPVHDLEIEAMT AqueK100_Aque ------------------------------------------------------------ AqueK101_Aque ------------------------------------------------------------ Cdk9_Dmel -------------------STPSNVGSS-------SSR--TMSLMEKQKYIEDY--DFPY CDK9_Mmus --------------------------------------------------YDSV--ECPF H25P06.2_Cele -------------------TTPSSSGGGQTPNGTNYELEVKQQLSNYQKLFDQA--TYPF CDK9_Hsap --------------------------------------------------YDSV--ECPF CDK9_Spur -------------------SGPP-VQSS-------ANQ--GYKMAMAPYQRESP--EFKY SGV1_Scer -------------------STPA-IQRD-------AKT--NLTYIKLRKRSSE--KVYGC CC1G_11325_Ccin AIETETTDPRLMNNPPPPPTAPPKIRVV--KRRTASKRTDK-------QDMEAYGRVFVG AqueK100_Aque ------------------------------------------------------------ AqueK101_Aque ---------------------------------------------------RTV--NLPY Cdk9_Dmel CDESNKYEKVAKIGQGTFGE-----------VFKAREKKGNKKFVAMKKVLMDNEKEGFP CDK9_Mmus CDEVTKYEKLAKIGQGTFGE-----------VFKAKHRQT-GQKVALKKVLMENEKEGFP H25P06.2_Cele IRDVSTYEKLNKIGQGTFGQVLQGRKSRNSEVFKARCKNT-GRMVALKKILMENEKEGFP CDK9_Hsap CDEVSKYEKLAKIGQGTFGE-----------VFKARHRKT-GQKVALKKVLMENEKEGFP CDK9_Spur CEEVSKYDKLAKIGQGTFGE-----------VFKAKHKKN-KNIVALKKVLMENEKEGFP SGV1_Scer TVFQNHYREDEKLGQGTFGE-----------VYKGIHLET-QRQVAMKKIIVSVEKDLFP CC1G_11325_Ccin CGQQSDYEVTTKLGEGTFGE-----------VHKAIQKAT-GASVALKRILMHHEKEGMP AqueK100_Aque ------------------------------------------------------------ AqueK101_Aque CPEVGKYEKLTKVGQGTFGE-----------VFKAKDRKT-GRLVALKKVCMENEKEGFP Cdk9_Dmel ITALREIRILQLLKHENVVNLIEICRTKATA-----TNGYRSTFYLVFDFCEHDLAGLLS CDK9_Mmus ITALREIKILQLLKHENVVNLIEICRTKASP-----YNRCKGSIYLVFDFCEHDLAGLLS H25P06.2_Cele ITALREVKMLEQLKHPNITDLIEVCSAKSTG---TTGSKDRATFYLVMALCAHDLAGLLS CDK9_Hsap ITALREIKILQLLKHENVVNLIEICRTKASP-----YNRCKGSIYLVFDFCEHDLAGLLS CDK9_Spur ITALREIRILQLLRHENVVPLYEICRTKATA-----YNRYKGSIYLVFEFCEHDLAGLLS SGV1_Scer ITAQREITILKRLNHKNIIKLIEMVYDHSPDITNAASSNLHKSFYMILPYMVADLSGVLH CC1G_11325_Ccin VTALREIKILKALKHPCIVNILDMFVVRSSE-------KDPLSVYMVFPYMDHDLAGLLE AqueK100_Aque -----------------------LLFLSATP-----YNRDKGSIYLVLDFCEHDLAGLLE AqueK101_Aque MTALREIRILQLLQHNNIVNLVEICRSKATP-----YNRDKGSIYLVLDFCEHDLAGLLE : :. :.*::: **:*:* Cdk9_Dmel NMNVKFSLGEIKKVMQQLLNGLYYIHSNKILHRDMKAANVLITKHGILKLADFGLARAFS CDK9_Mmus NVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFS H25P06.2_Cele NPKIRMSLVHIKTMMKHLMSGLNKLHRSKILHRDMKAANVLISKDGILKLADFGLARPFV CDK9_Hsap NVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFS CDK9_Spur NTNVKFSLGEIKSVIKQLLNGLYYIHSNKVLHRDMKAANILITKAGVLKLADFGLARAFS SGV1_Scer NPRINLEMCDIKNMMLQILEGLNYIHCAKFMHRDIKTANILIDHNGVLKLADFGLARLYY CC1G_11325_Ccin NERVKLQPSQIKLYMKQLLEGTEYMHRNHILHRDMKAANLLISNTGNLRIADFGLARSFD AqueK100_Aque CKEIKFSLSEIKNIMQQLFNALAYIHGNNILHRDMKSCNILVTRKGELKLADFGLARALN AqueK101_Aque CKEIKFSLSEIKNIMQQLFNALAYIHGNNILHRDMKSCNILVTRKGELKLADFGLARALN :.: .** : ::.. :* :.:***:*:.*:*: . * *::******* Cdk9_Dmel -------IPKN--ESKNRYTNRVVTLWYRPPELLLGDRNYGPPVDMWGAGCIMAEMWTRS CDK9_Mmus -------LAKN--SQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRS H25P06.2_Cele -------QRENGAGPRPLYTNRVVTLWYRPPELLLGDRQYGTKIDVWGAGCIMAEMWTRQ CDK9_Hsap -------LAKN--SQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRS CDK9_Spur -------LPKG--DAPNRYTNRVVTLWYRPPELLLGERNYGPAIDLWGAGCIMAEMWTRS SGV1_Scer GCPPNLKYPG-GAGSGAKYTSVVVTRWYRAPELVLGDKQYTTAVDIWGVGCVFAEFFEKK CC1G_11325_Ccin TN-----ITKG--GSTRKYTNCVVTRWYRPPELLLGARQYGGEVDIWGIGCVLGEMFNRR AqueK100_Aque -------K-----GTNQRYTNRVVTLWYRPPELFLGERNYGPPIDMWGAGCIMAEMWTRR AqueK101_Aque -------K-----GANQRYTNRVVTLWYRPPELFLGERNYGPPIDMWGAGCIMAEMWTRR **. *** ***.***.** ::* :*:** **::.*:: : Cdk9_Dmel PIMQGNTEQQQLTFISQLCGSFTPDVWPGVEELELYKSIE------LPK-NQKRRVKERL CDK9_Mmus PIMQGNTEQHQLALISQLCGSITPEVWPNVDKYELFEKLE------LVK-GQKRKVKDRL H25P06.2_Cele PIMQGDTEQKQLQLISGLCGSINKDVWPNCVNMPLWSAMSSEPNSALPQ-GKYRILPNKM CDK9_Hsap PIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLE------LVK-GQKRKVKDRL CDK9_Spur PIMQGNTEQHQLTLISHLCGSITSAVWPGLEKLELSNTLE------LPK-GHKRKVKDRL SGV1_Scer PILQGKTDIDQGHVIFKLLGTPTEEDWAVARYLPG---AE------LTTTNYKPTLRERF CC1G_11325_Ccin PILPGSSDLDQLEKIWYLCGTPTQHSWPNFDALPGCDGVK------HFKSNHIRRVKMTY AqueK100_Aque PIMQGDTEQKQITLICQLCGSISPTEWAGVEKLEYYQKLE------LPQ-KENRKLKERL AqueK101_Aque PIMQGDTEQKQITLICQLCGSISPTEWAGVEKLEYYQKLE------LPQ-KENRKLKERL **: *.:: .* * * *: . *. . : Cdk9_Dmel RPY----------------------VKDQTGCDLLDKLLTLDPKKRIDADTALNHDFFWT CDK9_Mmus KAY----------------------VRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWS H25P06.2_Cele KNLMKFDAPDSKTDPFGKNVKQHDSATDDDALHLLEILLAIDPDKRPTSDEAEDDIWFFK CDK9_Hsap KAY----------------------VRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWS CDK9_Spur RSY----------------------VKDQQALDLIDKLLNIDPKRRMDAAIALDHDFFWS SGV1_Scer GKY----------------------LSE-TGLDFLGQLLALDPYKRLTAMSAKHHPWFKE CC1G_11325_Ccin ES------------------------VGAETADLLDKLLVCNPKERITAAQALEHEYFWT AqueK100_Aque RHF----------------------VEDPYALDLIDKLLMLDPRKRIDADSTLEHDFFWK AqueK101_Aque RHF----------------------VEDPYALDLIDKLLMLDPRKRIDADSTLEHDFFWK .:: ** :* .* : : .. :* Cdk9_Dmel DPMPS-DLSKMLSQHLQSMFEYLAQPR----RSNQMRN---------------------- CDK9_Mmus DPMPS-DLKGMLSTHLTSMFEYLAPPR----RKGSQIT---------------------- H25P06.2_Cele DPVPMANVQDLMDTIPNSQFEYTVGKGAHANRGRHQNA---------------------- CDK9_Hsap DPMPS-DLKGMLSTHLTSMFEYLAPPR----RKGSQIT---------------------- CDK9_Spur DPMPC-SLERMLSTHTQSMFEYLTPRR----RQQHPAA---------------------- SGV1_Scer DPLPS-EKITL-PTEESHEADIKR--Y-KE--------EMHQSLSQRVPTAPRGHIVEKG CC1G_11325_Ccin DPLPA-DPKTLPVYEASHEFDKRGQ-RNHQPMMGHHQPSKYQDPSHRLPP-PAGNP---- AqueK100_Aque DPLPT-DLSKTLSTLRSSMFVMHTGSH----K---PLP---------------------- AqueK101_Aque DPLPT-DLSKTLSTLRSSMFVMHTGSH----K---PLP---------------------- **:* . Cdk9_Dmel ------------------------------------------Y----------------- CDK9_Mmus ------------------------------------------Q----------------- H25P06.2_Cele ------------------------------------------Q----------------- CDK9_Hsap ------------------------------------------Q----------------- CDK9_Spur ------------------------------------------A----------------- SGV1_Scer ESPVVKNLGAIPRGPKKDDASFLPPSKNVLAKPPPSKIRELHQNPRPYHVNSGYAKTAIP CC1G_11325_Ccin ------------------------------------------Q----------------- AqueK100_Aque ------------------------------------------G----------------- AqueK101_Aque ------------------------------------------G----------------- Cdk9_Dmel ---------------------------H----QQ-------------------------- CDK9_Mmus ---------------------------Q-------------------------------- H25P06.2_Cele ---------------------------Q-------------------------------- CDK9_Hsap ---------------------------Q-------------------------------- CDK9_Spur ---------------------------AAANHRNP------------------------- SGV1_Scer PPAAPAGVNRYGPNNSSRNNRFSGNSTAPNNSRNPVNRFHPETNVSSKYNKVP------- CC1G_11325_Ccin --------------------------RRQGNHRGP-----------------PGPWPGAP AqueK100_Aque ---------------------------P-------------------------------- AqueK101_Aque ---------------------------P-------------------------------- Cdk9_Dmel ------------------------------------------------------------ CDK9_Mmus ------------------------------------------------------------ H25P06.2_Cele ------------------------------------------------------------ CDK9_Hsap ------------------------------------------------------------ CDK9_Spur ------------------------------------------------------------ SGV1_Scer -----------LPLGPQSRYQGNSNESRYKNSPNDSRYHNPRYVNKPETNFNRQP----- CC1G_11325_Ccin PLSHGPHAHPPGP-G-------SY-------------------------NMNQGPPPGMS AqueK100_Aque ------------------------------------------------------------ AqueK101_Aque ------------------------------------------------------------ Cdk9_Dmel ------------------------------------------------------------ CDK9_Mmus ------------------------------------------------------------ H25P06.2_Cele ------------------------------------------------------------ CDK9_Hsap ------------------------------------------------------------ CDK9_Spur ------------------------------------------------------------ SGV1_Scer ---------------------------------------------------QKYSRQESN CC1G_11325_Ccin GPPPPGFRPGPPGGIPMNPNMGPGPYPGGRPQFNGPGGPRPPGPGAYSLPPNPGGRPPFR AqueK100_Aque ------------------------------------------------------------ AqueK101_Aque ------------------------------------------------------------ Cdk9_Dmel --------------------------------------------------------LTTM CDK9_Mmus --------------------------------------------------------STNQ H25P06.2_Cele --------------------------------------------------------RPNQ CDK9_Hsap --------------------------------------------------------STNQ CDK9_Spur -------------------------H------------------------------HANP SGV1_Scer APINKNYNPSNGSRNMAGD------HH--------------------------QGSRPSH CC1G_11325_Ccin GPHNGPPGPPGGPGRMGGPGLPPRPSVSLPPKPAAPLGGGVALGTVPRSNVPMPGRRPQP AqueK100_Aque --------------------------------------------------------RPTQ AqueK101_Aque --------------------------------------------------------RPTQ . Cdk9_Dmel --NQK--P--Q--------------------------------DNSMIDRVW CDK9_Mmus --SRN--PATT--------------------------------NQTEFERVF H25P06.2_Cele QQARP--SNAIP-------------------------------AGQYRDTIF CDK9_Hsap --SRN--PATT--------------------------------NQTEFERVF CDK9_Spur -PNRP--STAA--------------------------------PDQNFDRVF SGV1_Scer --PQF--PISPSQGQHQLTSKPIEKKNGSFKDERAKPDESKEFQNSDIADLY CC1G_11325_Ccin PQPHPPPPSTGSGNG---------------------------YAPNGGLNYG AqueK100_Aque --SQP--PNVV--------------------------------SGNVHDRVF AqueK101_Aque --SQP--PNVV--------------------------------SGNVHDRVF : .